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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHV7-81 Gene

protein-coding   GIFtS: 30
GCID: GC14M107282

immunoglobulin heavy variable 7-81 (non-functional)

(Previous name: immunoglobulin heavy variable 7-81 )
  Search for IGHV7-81
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGHV7-81    

Aliases
for IGHV7-81 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Heavy Variable 7-81 (Non-Functional)1 2
Immunoglobulin Heavy Variable 7-811
IGHV7812

External Ids:    HGNC: 56691   Entrez Gene: 283782   Ensembl: ENSG000002119797   UniProtKB: Q6PIL04   

Export aliases for IGHV7-81 gene to outside databases

Previous GC identifers: GC14U990135 GC14M105051 GC14M105254 GC14M106353 GC14M087435


Summaries
for IGHV7-81 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGHV7-81 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHV7-81
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHV7-81

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHV7-81


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHV7-81 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHV7-81 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M107282:  view genomic region     (about GC identifiers)

Start:
 107,282,790 bp from pter      End:
 107,283,280 bp from pter
Size:
 491 bases      Orientation:
 minus strand

Proteins
for IGHV7-81 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/TrEMBL: Q6PIL0 (See protein sequence)
Recommended Name: IGHV7-81 protein  
Size: 125 amino acids; 13913 Da

IGHV7-81 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000375048  
Reactome Protein details: Q6PIL0
Human Recombinant Protein Products: 
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Protein Domains /
Families
for IGHV7-81 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGHV7-81 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like_dom
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q6PIL0

ProtoNet protein and cluster: Q6PIL0

2 Blocks protein families:
IPB003596 Immunoglobulin V-type
IPB013106 Immunoglobulin V-set



Function
for IGHV7-81 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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In Situ Assay
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Pathways & Interactions
for IGHV7-81 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Cleavage of Alpha-1-Microglobulin
8/11 pathways (see all 11)
Cleavage of Alpha-1-Microglobulin1.00
FCGR activation0.65
Binding and Uptake of Ligands by Scavenger Receptors0.79
Initial triggering of complement0.60
Scavenging of Heme from Plasma0.79
Role of phospholipids in phagocytosis0.53
Classical antibody-mediated complement activation0.74
Complement cascade0.47
2Immune System
Immune System1.00
Innate Immune System0.46
Adaptive Immune System0.59
3Assembly of Signalosomes at the Activated BCR
Assembly of Signalosomes at the Activated BCR1.00
Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)0.45
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.78
4Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation1.00
Fcgamma receptor (FCGR) dependent phagocytosis0.80
Role of myosins in phagosome formation0.80
5Signaling by the B Cell Receptor (BCR)
Signaling by the B Cell Receptor (BCR)1.00

Pathway sources
See GeneCards unified pathways
Show all pathways


5/21        Reactome Pathways for IGHV7-81 (see all 21)
    Role of myosins in phagosome formation
FCGR activation
Cleavage of Alpha-1-Microglobulin
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts
Role of phospholipids in phagocytosis



IGHV7-81 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHV7-81

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for IGHV7-81 (ENSP000003750484) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
IGHV3-23ENSP000003750184STRING: ENSP00000375018
C1QAENSP000003637734STRING: ENSP00000363773
C1QBENSP000003139674STRING: ENSP00000313967
C1QCENSP000003637684STRING: ENSP00000363768
C1RENSP000002905754STRING: ENSP00000290575
About this table

Drugs & Compounds
for IGHV7-81 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHV7-81
Search CenterWatch for drugs/clinical trials and news about IGHV7-81 

Transcripts
for IGHV7-81 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for IGHV7-81:

Immunoglobulin heavy variable 7-81 (non-functional)
Hs.737487
Unigene Representative Sequence: BC032733
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390639

miRNA
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Inhib. RNA
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Browse OriGene siRNA
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Clone
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Primer
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Additional cDNA sequence: BC032733.1 

2 AceView cDNA sequences:

BC032733 BM478217 

GeneLoc Exon Structure


Expression
for IGHV7-81 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHV7-81 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTGCTCCA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See IGHV7-81 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGHV7-81

SOURCE GeneReport for Unigene cluster: Hs.737487
    SABiosciences Custom PCR Arrays for IGHV7-81
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In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHV7-81

Orthologs
for IGHV7-81 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGHV7-81 gene from 2/3 species (see all 3)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
lizard
(Anolis carolinensis)		 Reptilia IGHV5-516
 --
 48(a)
 1 → many
 GL343491.1(38006-38582)
zebrafish
(Danio rerio)		 Actinopterygii ighm6
ighv1-46
(see all 29)		 immunoglobulin heavy variable 1-4
(see all 29)		 8(a)
43(a)
(see all 29)		 many ↔ many
many ↔ many
(see all 29)		 3(34048543-34145441)
3(34106950-34107372)
        Species with no ortholog for IGHV7-81

ENSEMBL Gene Tree for IGHV7-81 (if available)
TreeFam Gene Tree for IGHV7-81 (if available) 

Paralogs
for IGHV7-81 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGHV7-81 gene
IGHV1-22  IGHV5-512  IGHV1-182  IGHV1-452  IGHV1-692  IGHV1-582  IGHV1-82  IGHV1-242  
IGHV1OR21-12  IGHV1-462  IGHV1-32  
18/54 SIMAP similar genes for IGHV7-81 using alignment to 1 protein entry:     Q6PIL0_HUMAN(see all similar genes):
DKFZp686C02220    IGHM    DKFZp686I15212    IgG VH    IgH    DKFZp686K03196
scFv    DKFZp686O16217    IGHV1OR21-1    HEL180    VH-7 family (N54P3)D/J    IGHV
VH    VH-3 family (VH26.)D/J    VH1    VH-3 family (VH26)D/J    DKFZp686I04196    VH3

IGHV7-81 for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for IGHV7-81
PGOHUM00000247936 PGOHUM00000247947 PGOHUM00000247953 PGOHUM00000247967


Genomic Variants
for IGHV7-81 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHV7-81
DNA2.0 Custom Variant and Variant Library Synthesis for IGHV7-81

Disorders / Diseases
for IGHV7-81 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Publications
for IGHV7-81 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGHV7-81 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGHV7-81)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  2. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  3. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. (PubMed id 9841928)1 Matsuda F....Honjo T. (1998)
  4. A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q. (PubMed id 7920635)1 Cook G.P....Rabbitts T.H. (1994)
  5. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (1976)
  6. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (1976)

External Searches for IGHV7-81 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGHV7-81 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28378 HGNC: 5669 AceView: IGHV7-81 Ensembl:ENSG00000211979 euGenes: HUgn28378
ECgene: IGHV7-81 H-InvDB: IGHV7-81

Other Databases showing IGHV7-81 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGHV7-81 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGHV7-81 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHV7-81 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGHV7-81 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGHV7-81 gene:
Search GeneIP for patents involving IGHV7-81

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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About This Section

 
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von Willebrand factor
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