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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHV7-81 Gene

protein-coding   GIFtS: 30
GCID: GC14M107282

Immunoglobulin Heavy Variable 7-81 (Non-Functional)

(Previous name: immunoglobulin heavy variable 7-81)
  Search for IGHV7-81
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Heavy Variable 7-81 (Non-Functional)1 2
Immunoglobulin Heavy Variable 7-811
IGHV7812

External Ids:    HGNC: 56691   Entrez Gene: 283782   Ensembl: ENSG000002119797   UniProtKB: Q6PIL04   

Export aliases for IGHV7-81 gene to outside databases

Previous GC identifers: GC14U990135 GC14M105051 GC14M105254 GC14M106353 GC14M087435


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGHV7-81 Gene: 
IGHV7-81 (immunoglobulin heavy variable 7-81 (non-functional)) is a protein-coding gene. Among its related super-pathways are Classical antibody-mediated complement activation and FCERI mediated MAPK activation. An important paralog of this gene is IGHV1-2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHV7-81
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHV7-81


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHV7-81 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHV7-81 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M107282:  view genomic region     (about GC identifiers)

Start:
107,282,790 bp from pter      End:
107,283,280 bp from pter
Size:
491 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/TrEMBL: Q6PIL0 (See protein sequence)
Recommended Name: IGHV7-81 protein  
Size: 125 amino acids; 13913 Da

Explore proteomics data for IGHV7-81 at MOPED 

IGHV7-81 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGHV7-81 Protein Expression

ENSEMBL proteins: 
 ENSP00000375048  
Reactome Protein details: Q6PIL0
Human Recombinant Protein Products for IGHV7-81: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGH: Immunoglobulins / IGH locus

4 InterPro protein domains:
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry Q6PIL0

ProtoNet protein and cluster: Q6PIL0

2 Blocks protein domains:
IPB003596 Immunoglobulin V-type
IPB013106 Immunoglobulin V-set



IGHV7-81 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
IGHV7-81 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IGHV7-81 About   (see all 7)                                                                                              See pathways by source

SuperPathContained pathways About
1Classical antibody-mediated complement activation
Classical antibody-mediated complement activation0.88
FCGR activation0.70
Creation of C4 and C2 activators0.88
Role of phospholipids in phagocytosis0.65
Initial triggering of complement0.86
FCERI mediated NF-kB activation0.47
Complement cascade0.76
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
2FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization0.60
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.31
FCERI mediated MAPK activation0.60
3Immune System
Immune System0.56
Innate Immune System0.50
Adaptive Immune System0.56
4Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation0.80
Fcgamma receptor (FCGR) dependent phagocytosis0.80
5Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling0.69
Role of LAT2/NTAL/LAB on calcium mobilization0.69

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/21        Reactome Pathways for IGHV7-81 (see all 21)
    FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
Role of phospholipids in phagocytosis
Binding and Uptake of Ligands by Scavenger Receptors



IGHV7-81 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHV7-81

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for IGHV7-81 (ENSP000003750484) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
IGHV3-23ENSP000003750184STRING: ENSP00000375018
C1QAENSP000003637734STRING: ENSP00000363773
C1QBENSP000003139674STRING: ENSP00000313967
C1QCENSP000003637684STRING: ENSP00000363768
C1SENSP000003281734STRING: ENSP00000328173
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHV7-81

Search CenterWatch for drugs/clinical trials and news about IGHV7-81

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for IGHV7-81:

Immunoglobulin heavy variable 7-81 (non-functional)
Hs.737487
Unigene Representative Sequence: BC032733
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390639
miRNA
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Additional mRNA sequence: BC032733.1 

2 AceView cDNA sequences:

BC032733 BM478217 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHV7-81 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCCTGCTCCA
IGHV7-81 Expression
About this image


See IGHV7-81 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGHV7-81

SOURCE GeneReport for Unigene cluster: Hs.737487
    SABiosciences Custom PCR Arrays for IGHV7-81
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IGHV7-81 gene from 3 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
oppossum
(Monodelphis domestica)
Mammalia --
--
(see all 3)
--
31(a)
27(a)
(see all 3)
possible ortholog
possible ortholog
(see all 3)
3(432834857-432835207)
3(432640537-432641574)
lizard
(Anolis carolinensis)
Reptilia IGHV5-516
Uncharacterized protein
48(a)
1 → many
GL343491.1(38006-38582)
zebrafish
(Danio rerio)
Actinopterygii ighv1-46
ighv1-16
(see all 15)
immunoglobulin heavy variable 1-1
(see all 15)
44(a)
43(a)
(see all 15)
many ↔ many
many ↔ many
(see all 15)
3(34106950-34107372)
3(34144993-34145449)


ENSEMBL Gene Tree for IGHV7-81 (if available)
TreeFam Gene Tree for IGHV7-81 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGHV7-81 gene
IGHV1-22  IGHV1OR15-92  IGHV1-182  IGHV5-512  IGHV1-452  IGHV1-692  IGHV1-582  IGHV1-82  
IGHV1-242  IGHV1OR15-12  IGHV1-462  IGHV1OR21-12  IGHV1-32  
18/54 SIMAP similar genes for IGHV7-81 using alignment to 1 protein entry:     Q6PIL0_HUMAN(see all similar genes):
DKFZp686C02220    IGHM    DKFZp686I15212    IgG VH    IgH    DKFZp686K03196
scFv    DKFZp686O16217    IGHV1OR21-1    HEL180    VH-7 family (N54P3)D/J    IGHV
VH    VH-3 family (VH26.)D/J    VH1    VH-3 family (VH26)D/J    DKFZp686I04196    VH3

IGHV7-81 for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for IGHV7-81
PGOHUM00000247936 PGOHUM00000247947 PGOHUM00000247953 PGOHUM00000247967


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGHV7-81 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGHV7-81)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  2. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  3. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. (PubMed id 9841928)1 Matsuda F....Honjo T. (1998)
  4. A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q. (PubMed id 7920635)1 Cook G.P....Rabbitts T.H. (1994)
  5. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (1976)
  6. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (1976)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28378 HGNC: 5669 AceView: IGHV7-81 Ensembl:ENSG00000211979 euGenes: HUgn28378
ECgene: IGHV7-81 H-InvDB: IGHV7-81

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGHV7-81 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHV7-81 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGHV7-81 gene:
Search GeneIP for patents involving IGHV7-81

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Biologicals
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 Search for Antibodies for IGHV7-81 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for IGHV7-81
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for IGHV7-81
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGHV7-81
 inGenious Targeting Laboratory - Custom generated mouse model solutions for IGHV7-81
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGHV7-81
Customized:
 lentivirus for stable overexpression of IGHV7-81
 lentivirus expression plasmids for stable overexpression of IGHV7-81
 adenovirus for overexpression of IGHV7-81
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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