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Aliases for IGHV5-10-1 Gene

Aliases for IGHV5-10-1 Gene

  • Immunoglobulin Heavy Variable 5-10-1 2 3 5
  • Immunoglobulin Heavy Variable 5-A (Provisional, Gene/Pseudogene) 2 3
  • Immunoglobulin Heavy Variable 5-A (Provisional) 2 3
  • IGHV5-A 3
  • IGHV5A 3

External Ids for IGHV5-10-1 Gene

Previous HGNC Symbols for IGHV5-10-1 Gene

  • IGHV5-A

Previous GeneCards Identifiers for IGHV5-10-1 Gene

  • GC14U901811

Summaries for IGHV5-10-1 Gene

GeneCards Summary for IGHV5-10-1 Gene

IGHV5-10-1 (Immunoglobulin Heavy Variable 5-10-1) is a Protein Coding gene. An important paralog of this gene is IGHV5-51.

UniProtKB/Swiss-Prot for IGHV5-10-1 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV5-10-1 Gene

Genomics for IGHV5-10-1 Gene

Regulatory Elements for IGHV5-10-1 Gene

Enhancers for IGHV5-10-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G106116 0.8 Ensembl dbSUPER 0.4 -8.3 -8337 0.4 CTCF BHLHE40 TRIM22 ZNF143 RAD21 IGHV3-11 IGHV5-10-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGHV5-10-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHV5-10-1 Gene

Chromosome:
14
Start:
106,107,972 bp from pter
End:
106,108,464 bp from pter
Size:
493 bases
Orientation:
Minus strand

Genomic View for IGHV5-10-1 Gene

Genes around IGHV5-10-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV5-10-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV5-10-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for IGHV5-10-1 Gene

Proteins for IGHV5-10-1 Gene

  • Protein details for IGHV5-10-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0J9YXX1-HV5X1_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 5-10-1
    Protein Accession:
    A0A0J9YXX1

    Protein attributes for IGHV5-10-1 Gene

    Size:
    117 amino acids
    Molecular mass:
    12773 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGHV5-10-1 Gene

Post-translational modifications for IGHV5-10-1 Gene

No Post-translational modifications

Other Protein References for IGHV5-10-1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV5-10-1 Gene

Domains & Families for IGHV5-10-1 Gene

Gene Families for IGHV5-10-1 Gene

Protein Domains for IGHV5-10-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV5-10-1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV5-10-1 Gene

Function for IGHV5-10-1 Gene

Molecular function for IGHV5-10-1 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV5-10-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGHV5-10-1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV5-10-1 Gene

Localization for IGHV5-10-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV5-10-1 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV5-10-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGHV5-10-1: view

No data available for Subcellular locations from COMPARTMENTS for IGHV5-10-1 Gene

Pathways & Interactions for IGHV5-10-1 Gene

SuperPathways for IGHV5-10-1 Gene

No Data Available

Interacting Proteins for IGHV5-10-1 Gene

Gene Ontology (GO) - Biological Process for IGHV5-10-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IGHV5-10-1: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV5-10-1 Gene

Drugs & Compounds for IGHV5-10-1 Gene

No Compound Related Data Available

Transcripts for IGHV5-10-1 Gene

mRNA/cDNA for IGHV5-10-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV5-10-1 Gene

No ASD Table

Relevant External Links for IGHV5-10-1 Gene

GeneLoc Exon Structure for
IGHV5-10-1
ECgene alternative splicing isoforms for
IGHV5-10-1

Expression for IGHV5-10-1 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV5-10-1 Gene

Orthologs for IGHV5-10-1 Gene

Evolution for IGHV5-10-1 Gene

ENSEMBL:
Gene Tree for IGHV5-10-1 (if available)
TreeFam:
Gene Tree for IGHV5-10-1 (if available)

No data available for Orthologs for IGHV5-10-1 Gene

Paralogs for IGHV5-10-1 Gene

Variants for IGHV5-10-1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV5-10-1 Gene

HV5X1_HUMAN-A0A0J9YXX1
There are several alleles. The sequence shown is that of IMGT allele IGHV5-10-1*03.

Relevant External Links for IGHV5-10-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV5-10-1

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV5-10-1 Gene

Disorders for IGHV5-10-1 Gene

No disorders were found for IGHV5-10-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV5-10-1 Gene

Publications for IGHV5-10-1 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64

Products for IGHV5-10-1 Gene

Sources for IGHV5-10-1 Gene

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