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Aliases for IGHV4-59 Gene

Aliases for IGHV4-59 Gene

  • Immunoglobulin Heavy Variable 4-59 2 3
  • Immunogloblin Heavy Chain Variable Region 3
  • IGHV459 3
  • VH 3

External Ids for IGHV4-59 Gene

Previous GeneCards Identifiers for IGHV4-59 Gene

  • GC14U990148
  • GC14M105054
  • GC14M105053
  • GC14M106154
  • GC14M107082
  • GC14M107084
  • GC14M107092
  • GC14M107186
  • GC14M107336
  • GC14M107488
  • GC14M107680

Summaries for IGHV4-59 Gene

GeneCards Summary for IGHV4-59 Gene

IGHV4-59 (Immunoglobulin Heavy Variable 4-59) is a Protein Coding gene. An important paralog of this gene is IGHV4-31.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV4-59 Gene

Genomics for IGHV4-59 Gene

Genomic Location for IGHV4-59 Gene

106,627,249 bp from pter
106,627,825 bp from pter
577 bases
Minus strand

Genomic View for IGHV4-59 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGHV4-59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV4-59 Gene

No data available for Regulatory Elements for IGHV4-59 Gene

Proteins for IGHV4-59 Gene

  • Protein details for IGHV4-59 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein IGHV4-59
    Protein Accession:
    Secondary Accessions:

    Protein attributes for IGHV4-59 Gene

    116 amino acids
    Molecular mass:
    12936 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGHV4-59 Gene

Proteomics data for IGHV4-59 Gene at MOPED

Post-translational modifications for IGHV4-59 Gene

No Post-translational modifications

Other Protein References for IGHV4-59 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV4-59 Gene

Domains for IGHV4-59 Gene

Gene Families for IGHV4-59 Gene

  • IGH :Immunoglobulins / IGH locus

Protein Domains for IGHV4-59 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV4-59: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV4-59 Gene

Function for IGHV4-59 Gene

Gene Ontology (GO) - Molecular Function for IGHV4-59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGHV4-59: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IGHV4-59 Gene

Localization for IGHV4-59 Gene

Subcellular locations from

Jensen Localization Image for IGHV4-59 Gene COMPARTMENTS Subcellular localization image for IGHV4-59 gene
Compartment Confidence
extracellular 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IGHV4-59 Gene

Pathways for IGHV4-59 Gene

SuperPathways for IGHV4-59 Gene

No Data Available

Interacting Proteins for IGHV4-59 Gene

Gene Ontology (GO) - Biological Process for IGHV4-59 Gene


No data available for Pathways by source for IGHV4-59 Gene

Transcripts for IGHV4-59 Gene

mRNA/cDNA for IGHV4-59 Gene

(261) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV4-59 Gene

No ASD Table

Relevant External Links for IGHV4-59 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHV4-59 Gene

mRNA expression in normal human tissues for IGHV4-59 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV4-59 Gene

This gene is overexpressed in Spleen (14.9), Colon - Transverse (8.1), and Small Intestine - Terminal Ileum (4.5).
genes like me logo Genes that share expressions with IGHV4-59: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for IGHV4-59 Gene

Orthologs for IGHV4-59 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGHV4-59 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 56 (a)
Species with no ortholog for IGHV4-59:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGHV4-59 Gene

Gene Tree for IGHV4-59 (if available)
Gene Tree for IGHV4-59 (if available)

Paralogs for IGHV4-59 Gene Pseudogenes for IGHV4-59 Gene

genes like me logo Genes that share paralogs with IGHV4-59: view

Variants for IGHV4-59 Gene

Relevant External Links for IGHV4-59 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGHV4-59 Gene

Disorders for IGHV4-59 Gene

No disorders were found for IGHV4-59 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for IGHV4-59 Gene

Publications for IGHV4-59 Gene

  1. Chromosomal organization of the human VH4 gene family. Location of individual gene segments. (PMID: 8454861) van der Maarel S. … Milner E.C. (J. Immunol. 1993) 3
  2. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. (PMID: 9841928) Matsuda F. … Honjo T. (J. Exp. Med. 1998) 3
  3. Diversification of Ig heavy chain genes in human preterm neonates prematurely exposed to environmental antigens. (PMID: 12133958) Bauer K. … Berek C. (J. Immunol. 2002) 3
  4. Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity. (PMID: 22051533) Kostareli E. … Stamatopoulos K. (Leukemia 2012) 3

Products for IGHV4-59 Gene

Sources for IGHV4-59 Gene

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