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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHV4-39 Gene

protein-coding   GIFtS: 18
GCID: GC14M107315

immunoglobulin heavy variable 4-39
 Explore 69 diseases affiliated with
IGHV4-39 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGHV4-39    

Aliases
for IGHV4-39 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Heavy Variable 4-391 2
IGHV4392
VH2

External Ids:    HGNC: 56511   Entrez Gene: 283942   Ensembl: ENSG000002119597   

Export aliases for IGHV4-39 gene to outside databases

Previous GC identifers: GC14U990150 GC14M104849 GC14M105948 GC14M106878 GC14M087008 GC14M106887 GC14M106925


Summaries
for IGHV4-39 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGHV4-39 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHV4-39
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHV4-39

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHV4-39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHV4-39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHV4-39 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M107315:  view genomic region     (about GC identifiers)

Start:
 106,877,617 bp from pter      End:
 106,878,126 bp from pter
Size:
 510 bases      Orientation:
 minus strand

Proteins
for IGHV4-39 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --
IGHV4-39 Protein expression data from MOPED and PaxDb:    About this image 
Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000375028  

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Protein Domains /
Families
for IGHV4-39 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for IGHV4-39 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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Gene Editing
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Clone
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In Situ Assay
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Pathways & Interactions
for IGHV4-39 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHV4-39

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for IGHV4-39 (ENSP000003750284) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
C3ENSP000002459074STRING: ENSP00000245907
About this table

Drugs & Compounds
for IGHV4-39 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHV4-39
Search CenterWatch for drugs/clinical trials and news about IGHV4-39 

Transcripts
for IGHV4-39 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390619

miRNA
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Inhib. RNA
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Browse OriGene siRNA
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Clone
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Primer
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  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHV4-39

24/63 AceView cDNA sequences (see all 63):

CR623477 BG950423 X54447 BU570309 AF408717 BX386888 AJ579297 X17678 
S63731 AJ579126 AJ579179 U00571 X56158 AY165854 U00566 AJ579168 
AJ579169 AJ579131 AW403538 AJ249629 AJ579134 AF398963 AF174082 M26436 

GeneLoc Exon Structure


Expression
for IGHV4-39 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHV4-39 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See IGHV4-39 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGHV4-39
Primer
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Browse OriGene validated miRNA SYBR primer pairs
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Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHV4-39
In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHV4-39

Orthologs
for IGHV4-39 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGHV4-39 gene from 1/2 species (see all 2)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
lizard
(Anolis carolinensis)		 Reptilia --
 --
 44(a)
 possible ortholog
 GL343491.1(248500-249330)


ENSEMBL Gene Tree for IGHV4-39 (if available)
TreeFam Gene Tree for IGHV4-39 (if available) 

Paralogs
for IGHV4-39 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGHV4-39 gene
IGHV4-42  IGHV2-262  IGHV2-52  IGHV4-612  IGHV4-282  IGHV4-592  IGHV6-12  IGHV4-342  
IGHV4-312  IGHV2-702  

IGHV4-39 for paralogs           About GeneDecksing



Genomic Variants
for IGHV4-39 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHV4-39
DNA2.0 Custom Variant and Variant Library Synthesis for IGHV4-39

Disorders / Diseases
for IGHV4-39 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGHV4-39 for disorders           About GeneDecksing

20/69 diseases for IGHV4-39 (see all 69):    About MalaCards
crimean-congo hemorrhagic fever    cll/sll    tick-borne encephalitis    cat-scratch disease
rift valley fever    subacute sclerosing panencephalitis    hypersensitivity reaction type ii disease    human immunodeficiency virus infectious disease
hemorrhagic fever    hydrops fetalis    infectious mononucleosis    japanese encephalitis
spotted fever    yellow fever    herpes zoster    typhoid fever
spontaneous abortion    ocular toxoplasmosis    q fever    hemorrhagic fever with renal syndrome

2 diseases from the University of Copenhagen DISEASES database for IGHV4-39:
Chronic lymphocytic leukemia     Lymphoma

Export disorders for IGHV4-39 gene to outside databases

Publications
for IGHV4-39 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGHV4-39 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGHV4-39)		    Utopia: connect your pdf to the dynamic
world of online information

  1. IGHV4-39 deletion polymorphism does not associate wit h risk or outcome of multiple sclerosis. (PubMed id 20471699)1 Watson C.T....Breden F. (2010)
  2. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. (PubMed id 9841928)1 Matsuda F....Honjo T. (1998)
  3. Chromosomal organization of the human VH4 gene family. Location of individual gene segments. (PubMed id 8454861)1 van der Maarel S....Milner E.C. (1993)

External Searches for IGHV4-39 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGHV4-39 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28394 HGNC: 5651 AceView: IGHV4-39 Ensembl:ENSG00000211959 euGenes: HUgn28394
ECgene: IGHV4-39 H-InvDB: IGHV4-39

Other Databases showing IGHV4-39 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGHV4-39 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGHV4-39 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHV4-39 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGHV4-39 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGHV4-39 gene:
Search GeneIP for patents involving IGHV4-39

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGHV4-39 gene

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Advanced Cell Diagnostics
About This Section

 
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