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Aliases for IGHV4-34 Gene

Aliases for IGHV4-34 Gene

  • Immunoglobulin Heavy Variable 4-34 2 3 5
  • Ig Heavy Chain V-II Region ARH-77 3 4
  • Immunogloblin Heavy Chain Variable Region 3
  • IGHV434 3
  • VH 3

External Ids for IGHV4-34 Gene

Previous GeneCards Identifiers for IGHV4-34 Gene

  • GC14U990151
  • GC14M104801
  • GC14M105900
  • GC14M106830
  • GC14M086960
  • GC14M106838
  • GC14M106864
  • GC14M106872
  • GC14M106912
  • GC14M107300
  • GC14M107454
  • GC14M107646
  • GC14M106537
  • GC14M107731
  • GC14M107824
  • GC14M107923
  • GC14M108022

Summaries for IGHV4-34 Gene

GeneCards Summary for IGHV4-34 Gene

IGHV4-34 (Immunoglobulin Heavy Variable 4-34) is a Protein Coding gene. Diseases associated with IGHV4-34 include Hairy Cell Leukemia. An important paralog of this gene is IGHV4-39.

UniProtKB/Swiss-Prot for IGHV4-34 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV4-34 Gene

Genomics for IGHV4-34 Gene

Regulatory Elements for IGHV4-34 Gene

Enhancers for IGHV4-34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G106373 1.3 Ensembl ENCODE dbSUPER 0.7 +0.5 495 0.7 CTCF BACH1 RAD21 ZFHX2 GLIS2 ZNF138 EGR1 ZNF143 ZNF207 SMC3 IGHV3-33-2 IGHV4-34
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGHV4-34 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHV4-34 Gene

Chromosome:
14
Start:
106,373,661 bp from pter
End:
106,374,145 bp from pter
Size:
485 bases
Orientation:
Minus strand

Genomic View for IGHV4-34 Gene

Genes around IGHV4-34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV4-34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV4-34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV4-34 Gene

Proteins for IGHV4-34 Gene

  • Protein details for IGHV4-34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06331-HV434_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 4-34
    Protein Accession:
    P06331
    Secondary Accessions:
    • A0A0A0MS12
    • A0A0G2JP38

    Protein attributes for IGHV4-34 Gene

    Size:
    123 amino acids
    Molecular mass:
    13815 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGHV4-34 Gene

Post-translational modifications for IGHV4-34 Gene

No Post-translational modifications

Other Protein References for IGHV4-34 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV4-34 Gene

Domains & Families for IGHV4-34 Gene

Gene Families for IGHV4-34 Gene

Protein Domains for IGHV4-34 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV4-34: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV4-34 Gene

Function for IGHV4-34 Gene

Molecular function for IGHV4-34 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV4-34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 3922855
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGHV4-34: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV4-34 Gene

Localization for IGHV4-34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV4-34 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV4-34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGHV4-34: view

No data available for Subcellular locations from COMPARTMENTS for IGHV4-34 Gene

Pathways & Interactions for IGHV4-34 Gene

SuperPathways for IGHV4-34 Gene

No Data Available

Interacting Proteins for IGHV4-34 Gene

Selected Interacting proteins: P06331-HV434_HUMAN for IGHV4-34 Gene via IID

Gene Ontology (GO) - Biological Process for IGHV4-34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 3922855
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGHV4-34: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV4-34 Gene

Drugs & Compounds for IGHV4-34 Gene

No Compound Related Data Available

Transcripts for IGHV4-34 Gene

mRNA/cDNA for IGHV4-34 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV4-34 Gene

No ASD Table

Relevant External Links for IGHV4-34 Gene

GeneLoc Exon Structure for
IGHV4-34
ECgene alternative splicing isoforms for
IGHV4-34

Expression for IGHV4-34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGHV4-34 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV4-34 Gene

This gene is overexpressed in Spleen (x14.6) and Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for IGHV4-34 Gene

This gene is overexpressed in Urine (48.2) and Serum (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHV4-34 Gene



Protein tissue co-expression partners for IGHV4-34 Gene

- Elite partner

Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV4-34 Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • lymphatic
  • respiratory
Organs:
Thorax:
  • lung
Abdomen:
  • spleen
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with IGHV4-34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for IGHV4-34 Gene

Orthologs for IGHV4-34 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGHV4-34 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 49 (a)
ManyToMany
Species where no ortholog for IGHV4-34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGHV4-34 Gene

ENSEMBL:
Gene Tree for IGHV4-34 (if available)
TreeFam:
Gene Tree for IGHV4-34 (if available)

Paralogs for IGHV4-34 Gene

Variants for IGHV4-34 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV4-34 Gene

HV434_HUMAN-P06331
There are several alleles. The sequence shown is that of IMGT allele IGHV4-34*01.

Relevant External Links for IGHV4-34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV4-34

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV4-34 Gene

Disorders for IGHV4-34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGHV4-34 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
hairy cell leukemia
  • hcl-v
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with IGHV4-34: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV4-34 Gene

Publications for IGHV4-34 Gene

  1. A cloned human immunoglobulin heavy chain gene with a novel direct- repeat sequence in 5' flanking region. (PMID: 3922855) Kudo A. … Watanabe T. (Gene 1985) 3 4 64
  2. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. (PMID: 20801898) Marincevic M. … Rosenquist R. (Haematologica 2010) 3 64
  5. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64

Products for IGHV4-34 Gene

Sources for IGHV4-34 Gene

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