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Aliases for IGHV4-30-4 Gene

Aliases for IGHV4-30-4 Gene

  • Immunoglobulin Heavy Variable 4-30-4 2 3
  • IGHV4304 3
  • IGHV4-3 3

External Ids for IGHV4-30-4 Gene

Summaries for IGHV4-30-4 Gene

GeneCards Summary for IGHV4-30-4 Gene

IGHV4-30-4 (Immunoglobulin Heavy Variable 4-30-4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGHV4-30-4 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV4-30-4 Gene

Genomics for IGHV4-30-4 Gene

Genomic Location for IGHV4-30-4 Gene

Chromosome:
14
Orientation:
Unknown strand

Genomic View for IGHV4-30-4 Gene


Cytogenetic band:
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for IGHV4-30-4 Gene

Proteins for IGHV4-30-4 Gene

  • Protein details for IGHV4-30-4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DP06-HVD34_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 4-30-4
    Protein Accession:
    P0DP06

    Protein attributes for IGHV4-30-4 Gene

    Size:
    118 amino acids
    Molecular mass:
    13156 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    SequenceCaution:
    • Sequence=CAA78607.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for IGHV4-30-4 Gene

Post-translational modifications for IGHV4-30-4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGHV4-30-4 Gene

Domains & Families for IGHV4-30-4 Gene

Gene Families for IGHV4-30-4 Gene

Protein Domains for IGHV4-30-4 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV4-30-4: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV4-30-4 Gene

Function for IGHV4-30-4 Gene

Molecular function for IGHV4-30-4 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV4-30-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGHV4-30-4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV4-30-4 Gene

Localization for IGHV4-30-4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV4-30-4 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV4-30-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGHV4-30-4: view

No data available for Subcellular locations from COMPARTMENTS for IGHV4-30-4 Gene

Pathways & Interactions for IGHV4-30-4 Gene

SuperPathways for IGHV4-30-4 Gene

No Data Available

Interacting Proteins for IGHV4-30-4 Gene

Gene Ontology (GO) - Biological Process for IGHV4-30-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IGHV4-30-4: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV4-30-4 Gene

Drugs & Compounds for IGHV4-30-4 Gene

No Compound Related Data Available

Transcripts for IGHV4-30-4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV4-30-4 Gene

No ASD Table

Relevant External Links for IGHV4-30-4 Gene

ECgene alternative splicing isoforms for
IGHV4-30-4

No data available for mRNA/cDNA for IGHV4-30-4 Gene

Expression for IGHV4-30-4 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV4-30-4 Gene

Orthologs for IGHV4-30-4 Gene

No data available for Orthologs and Evolution for IGHV4-30-4 Gene

Paralogs for IGHV4-30-4 Gene

No data available for Paralogs for IGHV4-30-4 Gene

Variants for IGHV4-30-4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV4-30-4 Gene

HVD34_HUMAN-P0DP06
There are several alleles. The sequence shown is that of IMGT allele IGHV4-30-4*01.

Relevant External Links for IGHV4-30-4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV4-30-4

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV4-30-4 Gene

Disorders for IGHV4-30-4 Gene

No disorders were found for IGHV4-30-4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV4-30-4 Gene

Publications for IGHV4-30-4 Gene

  1. Polymorphism of human immunoglobulin VH4 germ-line genes. (PMID: 1348029) Weng N.P. … Marcus D.M. (Eur. J. Immunol. 1992) 3 4 64
  2. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64

Products for IGHV4-30-4 Gene

Sources for IGHV4-30-4 Gene

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