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Aliases for IGHV3-9 Gene

Aliases for IGHV3-9 Gene

  • Immunoglobulin Heavy Variable 3-9 2 3
  • Ig Heavy Chain V-III Region DOB 3 4
  • Immunogloblin Heavy Chain Variable Region 3
  • IGHV39 3
  • VH 3

External Ids for IGHV3-9 Gene

Previous GeneCards Identifiers for IGHV3-9 Gene

  • GC14U990207
  • GC14M104523
  • GC14M105623
  • GC14M106553
  • GC14M086693
  • GC14M106679
  • GC14M106761
  • GC14M107409
  • GC14M107601

Summaries for IGHV3-9 Gene

GeneCards Summary for IGHV3-9 Gene

IGHV3-9 (Immunoglobulin Heavy Variable 3-9) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGHV3-9 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV3-9 Gene

Genomics for IGHV3-9 Gene

Genomic Location for IGHV3-9 Gene

Chromosome:
14
Start:
26,000 bp from pter
End:
26,561 bp from pter
Size:
562 bases
Orientation:
Plus strand

Genomic View for IGHV3-9 Gene

Genes around IGHV3-9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV3-9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV3-9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV3-9 Gene

No data available for Regulatory Elements for IGHV3-9 Gene

Proteins for IGHV3-9 Gene

  • Protein details for IGHV3-9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01782-HV309_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 3-9
    Protein Accession:
    P01782

    Protein attributes for IGHV3-9 Gene

    Size:
    118 amino acids
    Molecular mass:
    12945 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

neXtProt entry for IGHV3-9 Gene

Post-translational modifications for IGHV3-9 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGHV3-9 Gene

Domains & Families for IGHV3-9 Gene

Gene Families for IGHV3-9 Gene

Protein Domains for IGHV3-9 Gene

Graphical View of Domain Structure for InterPro Entry

P01782

UniProtKB/Swiss-Prot:

HV309_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGHV3-9: view

No data available for Suggested Antigen Peptide Sequences for IGHV3-9 Gene

Function for IGHV3-9 Gene

Molecular function for IGHV3-9 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV3-9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 114209
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGHV3-9: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV3-9 Gene

Localization for IGHV3-9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV3-9 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV3-9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with IGHV3-9: view

No data available for Subcellular locations from COMPARTMENTS for IGHV3-9 Gene

Pathways & Interactions for IGHV3-9 Gene

SuperPathways for IGHV3-9 Gene

No Data Available

Interacting Proteins for IGHV3-9 Gene

Gene Ontology (GO) - Biological Process for IGHV3-9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 114209
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGHV3-9: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV3-9 Gene

Transcripts for IGHV3-9 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV3-9 Gene

No ASD Table

Relevant External Links for IGHV3-9 Gene

GeneLoc Exon Structure for
IGHV3-9
ECgene alternative splicing isoforms for
IGHV3-9

Expression for IGHV3-9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGHV3-9 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV3-9 Gene

This gene is overexpressed in Spleen (x14.5), Colon - Transverse (x6.8), Minor Salivary Gland (x6.5), and Small Intestine - Terminal Ileum (x5.2).

Protein differential expression in normal tissues from HIPED for IGHV3-9 Gene

This gene is overexpressed in Urine (31.0), Saliva (23.3), and Serum (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHV3-9 Gene



Protein tissue co-expression partners for IGHV3-9 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGHV3-9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHV3-9 Gene

Orthologs for IGHV3-9 Gene

No data available for Orthologs and Evolution for IGHV3-9 Gene

Paralogs for IGHV3-9 Gene

No data available for Paralogs for IGHV3-9 Gene

Variants for IGHV3-9 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV3-9 Gene

HV309_HUMAN-P01782
There are several alleles. The sequence shown is that of IMGT allele IGHV3-9*01.

Relevant External Links for IGHV3-9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV3-9

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV3-9 Gene

Disorders for IGHV3-9 Gene

No disorders were found for IGHV3-9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV3-9 Gene

Publications for IGHV3-9 Gene

  1. Amino acid sequence of the heavy-chain variable region of the crystallizable human myeloma protein Dob. (PMID: 114209) Steiner L.A. … Margolies M.N. (Biochemistry 1979) 3 4 64
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64

Products for IGHV3-9 Gene

Sources for IGHV3-9 Gene

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