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IGHV3-30-5 Gene(Protein Coding)

Immunoglobulin Heavy Variable 3-30-5

GCID:
GC14U990454
GIFtS:
8
Genes Participants
UDN Logo

Aliases for IGHV3-30-5 Gene

Aliases for IGHV3-30-5 Gene

  • Immunoglobulin Heavy Variable 3-30-5 2 3
  • IGHV3305 3
  • IGHV3-3 3

External Ids for IGHV3-30-5 Gene

Summaries for IGHV3-30-5 Gene

GeneCards Summary for IGHV3-30-5 Gene

IGHV3-30-5 (Immunoglobulin Heavy Variable 3-30-5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGHV3-30-5 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV3-30-5 Gene

Genomics for IGHV3-30-5 Gene

Products:

  1. Regulatory Element

Genomic Location for IGHV3-30-5 Gene

Chromosome:
14
Orientation:
Unknown strand

Genomic View for IGHV3-30-5 Gene


Cytogenetic band:
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for IGHV3-30-5 Gene

Proteins for IGHV3-30-5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IGHV3-30-5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DP03-HV335_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 3-30-5
    Protein Accession:
    P0DP03

    Protein attributes for IGHV3-30-5 Gene

    Size:
    117 amino acids
    Molecular mass:
    12947 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGHV3-30-5 Gene

Post-translational modifications for IGHV3-30-5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGHV3-30-5 Gene

Domains & Families for IGHV3-30-5 Gene

Gene Families for IGHV3-30-5 Gene

HGNC:

Protein Domains for IGHV3-30-5 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV3-30-5: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV3-30-5 Gene

Function for IGHV3-30-5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for IGHV3-30-5 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV3-30-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGHV3-30-5: view

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV3-30-5 Gene

Localization for IGHV3-30-5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV3-30-5 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV3-30-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGHV3-30-5: view

No data available for Subcellular locations from COMPARTMENTS for IGHV3-30-5 Gene

Pathways & Interactions for IGHV3-30-5 Gene

SuperPathways for IGHV3-30-5 Gene

PathCards logo More details on SuperPathways for IGHV3-30-5
No Data Available

Interacting Proteins for IGHV3-30-5 Gene

Gene Ontology (GO) - Biological Process for IGHV3-30-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IGHV3-30-5: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV3-30-5 Gene

Drugs & Compounds for IGHV3-30-5 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IGHV3-30-5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV3-30-5 Gene

No ASD Table

Relevant External Links for IGHV3-30-5 Gene

ECgene alternative splicing isoforms for
IGHV3-30-5

No data available for mRNA/cDNA for IGHV3-30-5 Gene

Expression for IGHV3-30-5 Gene

Products:

  1. Primer
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV3-30-5 Gene

Orthologs for IGHV3-30-5 Gene

No data available for Orthologs and Evolution for IGHV3-30-5 Gene

Paralogs for IGHV3-30-5 Gene

No data available for Paralogs for IGHV3-30-5 Gene

Variants for IGHV3-30-5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV3-30-5 Gene

HV335_HUMAN-P0DP03
There are several alleles. The sequence shown is that of IMGT allele IGHV3-30-5*01.

Relevant External Links for IGHV3-30-5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV3-30-5

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV3-30-5 Gene

Disorders for IGHV3-30-5 Gene

No disorders were found for IGHV3-30-5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV3-30-5 Gene

Publications for IGHV3-30-5 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  2. Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation. (PMID: 23541343) Watson C.T. … Breden F. (Am. J. Hum. Genet. 2013) 4 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64

Products for IGHV3-30-5 Gene

Sources for IGHV3-30-5 Gene

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