Aliases for IGHV3-30-5 Gene
Summaries for IGHV3-30-5 Gene
GeneCards Summary for IGHV3-30-5 Gene
IGHV3-30-5 (Immunoglobulin Heavy Variable 3-30-5) is a Protein Coding gene.
UniProtKB/Swiss-Prot for IGHV3-30-5 Gene
-
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
Additional gene information for IGHV3-30-5 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV3-30-5 Gene
Genomics for IGHV3-30-5 Gene
Regulatory Element Products
Genomic Locations for IGHV3-30-5 Gene
- chr14:-
- (GRCh38/hg38)
- Orientation:
- Unknown strand
Genomic View for IGHV3-30-5 Gene
No data available for GeneHancer (GH) Regulatory Elements and RefSeq DNA sequence for IGHV3-30-5 Gene
Proteins for IGHV3-30-5 Gene
-
Protein details for IGHV3-30-5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0DP03-HV335_HUMAN
- Recommended name:
- Immunoglobulin heavy variable 3-30-5
- Protein Accession:
- P0DP03
Protein attributes for IGHV3-30-5 Gene
- Size:
- 117 amino acids
- Molecular mass:
- 12947 Da
- Quaternary structure:
-
- Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
Post-translational modifications for IGHV3-30-5 Gene
Antibody Products
- Search GeneTex for Antibodies for IGHV3-30-5
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for IGHV3-30-5
- Origene Custom Protein Services for IGHV3-30-5
- Search GeneTex for Proteins for IGHV3-30-5
No data available for DME Specific Peptides for IGHV3-30-5 Gene
Domains & Families for IGHV3-30-5 Gene
Gene Families for IGHV3-30-5 Gene
Protein Domains for IGHV3-30-5 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV3-30-5 Gene
Function for IGHV3-30-5 Gene
Molecular function for IGHV3-30-5 Gene
- UniProtKB/Swiss-Prot Function:
- V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003823 | antigen binding | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IGHV3-30-5
-
- Search ViGene Biosciences for IGHV3-30-5
CRISPR Products
- Browse CRISPR knockouts for IGHV3-30-5
- Applied Biological Materials CRISPR for IGHV3-30-5
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for IGHV3-30-5
Inhibitory RNA Products
- Search ViGene Biosciences for IGHV3-30-5
Clone Products
- GenScript: Custom all cDNA clones Services for IGHV3-30-5
- VectorBuilder custom plasmid, inducible vectors for IGHV3-30-5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGHV3-30-5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGHV3-30-5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV3-30-5 Gene
Localization for IGHV3-30-5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGHV3-30-5 Gene
- Secreted. Cell membrane.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGHV3-30-5 Gene
Pathways & Interactions for IGHV3-30-5 Gene
Interacting Proteins for IGHV3-30-5 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for IGHV3-30-5 Gene
Transcripts for IGHV3-30-5 Gene
CRISPR Products
- Browse CRISPR knockouts for IGHV3-30-5
- Applied Biological Materials CRISPR for IGHV3-30-5
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for IGHV3-30-5
Inhibitory RNA Products
- Search ViGene Biosciences for IGHV3-30-5
Clone Products
- GenScript: Custom all cDNA clones Services for IGHV3-30-5
- VectorBuilder custom plasmid, inducible vectors for IGHV3-30-5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGHV3-30-5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGHV3-30-5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Relevant External Links for IGHV3-30-5 Gene
- ECgene alternative splicing isoforms for
- IGHV3-30-5
No data available for mRNA/cDNA for IGHV3-30-5 Gene
Expression for IGHV3-30-5 Gene
Primer Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV3-30-5 Gene
Orthologs for IGHV3-30-5 Gene
No data available for Orthologs and Evolution for IGHV3-30-5 Gene
Paralogs for IGHV3-30-5 Gene
No data available for Paralogs for IGHV3-30-5 Gene
Variants for IGHV3-30-5 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV3-30-5 Gene
- HV335_HUMAN-P0DP03
- There are several alleles. The sequence shown is that of IMGT allele IGHV3-30-5*01.
Additional Variant Information for IGHV3-30-5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IGHV3-30-5
No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV3-30-5 Gene
Disorders for IGHV3-30-5 Gene
No disorders were found for IGHV3-30-5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV3-30-5 Gene
Publications for IGHV3-30-5 Gene
- Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
- Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation. (PMID: 23541343) Watson CT … Breden F (American journal of human genetics 2013) 4 58
- Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 58
- Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 58
- Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4 58
Products for IGHV3-30-5 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for IGHV3-30-5
- Origene Custom Protein Services for IGHV3-30-5
- Browse OriGene Inhibitory RNA Products For IGHV3-30-5
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for IGHV3-30-5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IGHV3-30-5
- GenScript: Custom all cDNA clones Services for IGHV3-30-5
- GenScript Custom Purified and Recombinant Proteins Services for IGHV3-30-5
- GenScript Custom Assay Services for IGHV3-30-5
- GenScript Custom overexpressing Cell Line Services for IGHV3-30-5
- Browse GenScript CRISPR for IGHV3-30-5
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IGHV3-30-5
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for IGHV3-30-5
- VectorBuilder custom plasmid, inducible vectors for IGHV3-30-5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGHV3-30-5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for IGHV3-30-5
- Search GeneTex for Proteins for IGHV3-30-5
Sources for IGHV3-30-5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew