Aliases for IGHV3-23 Gene
External Ids for IGHV3-23 Gene
ORGUL Members for IGHV3-23 Gene
Previous GeneCards Identifiers for IGHV3-23 Gene
IGHV3-23 belongs to a cluster of approximately 40 functional variable (V) genes in the immunoglobulin (Ig) heavy chain locus on chromosome 14. For background information on the Ig heavy chain and the V gene cluster, see (MIM 147070).[supplied by OMIM, Apr 2008]
GeneCards Summary for IGHV3-23 Gene
IGHV3-23 (Immunoglobulin Heavy Variable 3-23) is a Protein Coding gene. Among its related pathways are Immune response Fc epsilon RI pathway and Immune response NFAT in immune response. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHV3-64.
UniProtKB/Swiss-Prot for IGHV3-23 Gene
V segment of the variable region of immunoglobulins heavy chain that participates to the antigen recognition. Immunoglobulins (Igs), also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound Igs serve as receptors which, upon binding of a specific antigen (Ag), trigger the clonal expansion and differentiation of B lymphocytes into Ig-secreting plasma cells. Secreted Igs mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable region of one heavy chain, together with that of its associated light chain. Thus, each Ig has two antigen binding sites with remarkable affinity for a particular antigen. The variable regions are assembled by a process called V(D)J recombination and can then be subjected to somatic hypermutation after exposure to antigen to allow affinity maturation for a particular Ag (PubMed:20176268, PubMed:17576170).