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Aliases for IGHV3-23 Gene

Aliases for IGHV3-23 Gene

  • Immunoglobulin Heavy Variable 3-23 2 3 5
  • Mu-Chain Precursor (AA -19 To 142) 3
  • Ig Heavy Chain V-III Region VH26 4
  • Ig Heavy Chain V-III Region LAY 4
  • Ig Heavy Chain V-III Region POM 4
  • Ig Heavy Chain V-III Region TEI 4
  • Ig Heavy Chain V-III Region TIL 4
  • Ig Heavy Chain V-III Region TUR 4
  • Ig Heavy Chain V-III Region WAS 4
  • Ig Heavy Chain V-III Region ZAP 4
  • IGHV323 3
  • V3-23 3
  • DP47 3
  • VH26 3

External Ids for IGHV3-23 Gene

Previous GeneCards Identifiers for IGHV3-23 Gene

  • GC14U990198
  • GC14M104696
  • GC14M105796
  • GC14M106726
  • GC14M086866
  • GC14M106729
  • GC14M107433
  • GC14M107625

Summaries for IGHV3-23 Gene

Entrez Gene Summary for IGHV3-23 Gene

  • IGHV3-23 belongs to a cluster of approximately 40 functional variable (V) genes in the immunoglobulin (Ig) heavy chain locus on chromosome 14. For background information on the Ig heavy chain and the V gene cluster, see (MIM 147070).[supplied by OMIM, Apr 2008]

GeneCards Summary for IGHV3-23 Gene

IGHV3-23 (Immunoglobulin Heavy Variable 3-23) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Immune response Fc epsilon RI pathway. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHV3-64.

UniProtKB/Swiss-Prot for IGHV3-23 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV3-23 Gene

Genomics for IGHV3-23 Gene

Regulatory Elements for IGHV3-23 Gene

Enhancers for IGHV3-23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F106268 1 Ensembl ENCODE 0.8 -0.2 -247 1.9 TBP CTCF RNF2 POLR2A MLLT1 RAD21 IGHV3-23 IGHV1-24
GH14F106275 1 Ensembl ENCODE 0.4 -7.6 -7581 1.5 PKNOX1 MAZ POLR2A IKZF1 MLLT1 TBX21 IGHV3-19 IGHV1-24 IGHV3-23
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGHV3-23 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHV3-23 Gene

Chromosome:
14
Start:
106,268,606 bp from pter
End:
106,269,140 bp from pter
Size:
535 bases
Orientation:
Minus strand

Genomic View for IGHV3-23 Gene

Genes around IGHV3-23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV3-23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV3-23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV3-23 Gene

Proteins for IGHV3-23 Gene

  • Protein details for IGHV3-23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01764-HV323_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 3-23
    Protein Accession:
    P01764
    Secondary Accessions:
    • A0A087WSX3
    • P01765
    • P01774
    • P01775
    • P01776
    • P01777
    • P01778
    • P01779

    Protein attributes for IGHV3-23 Gene

    Size:
    117 amino acids
    Molecular mass:
    12582 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

    Three dimensional structures from OCA and Proteopedia for IGHV3-23 Gene

neXtProt entry for IGHV3-23 Gene

Post-translational modifications for IGHV3-23 Gene

No Post-translational modifications

Other Protein References for IGHV3-23 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV3-23 Gene

Domains & Families for IGHV3-23 Gene

Gene Families for IGHV3-23 Gene

Protein Domains for IGHV3-23 Gene

Graphical View of Domain Structure for InterPro Entry

P01764

UniProtKB/Swiss-Prot:

HV323_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGHV3-23: view

No data available for Suggested Antigen Peptide Sequences for IGHV3-23 Gene

Function for IGHV3-23 Gene

Molecular function for IGHV3-23 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV3-23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS,IBA 4139708
GO:0004252 serine-type endopeptidase activity TAS --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGHV3-23: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV3-23 Gene

Localization for IGHV3-23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV3-23 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV3-23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane IEA,TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGHV3-23: view

No data available for Subcellular locations from COMPARTMENTS for IGHV3-23 Gene

Pathways & Interactions for IGHV3-23 Gene

genes like me logo Genes that share pathways with IGHV3-23: view

Gene Ontology (GO) - Biological Process for IGHV3-23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
genes like me logo Genes that share ontologies with IGHV3-23: view

No data available for SIGNOR curated interactions for IGHV3-23 Gene

Drugs & Compounds for IGHV3-23 Gene

(1) Drugs for IGHV3-23 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lauryl Dimethylamine-N-Oxide Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGHV3-23: view

Transcripts for IGHV3-23 Gene

mRNA/cDNA for IGHV3-23 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV3-23 Gene

No ASD Table

Relevant External Links for IGHV3-23 Gene

GeneLoc Exon Structure for
IGHV3-23
ECgene alternative splicing isoforms for
IGHV3-23

Expression for IGHV3-23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGHV3-23 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV3-23 Gene

This gene is overexpressed in Spleen (x12.0) and Colon - Transverse (x7.8).

Protein differential expression in normal tissues from HIPED for IGHV3-23 Gene

This gene is overexpressed in Serum (40.0) and Urine (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHV3-23 Gene



Protein tissue co-expression partners for IGHV3-23 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGHV3-23: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHV3-23 Gene

Orthologs for IGHV3-23 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGHV3-23 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 73 (a)
ManyToMany
Species where no ortholog for IGHV3-23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGHV3-23 Gene

ENSEMBL:
Gene Tree for IGHV3-23 (if available)
TreeFam:
Gene Tree for IGHV3-23 (if available)

Paralogs for IGHV3-23 Gene

Variants for IGHV3-23 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV3-23 Gene

HV323_HUMAN-P01764
There are several alleles. The sequence shown is that of IMGT allele IGHV3-23*04.

Sequence variations from dbSNP and Humsavar for IGHV3-23 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_073326 --
VAR_073327 --

Relevant External Links for IGHV3-23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV3-23

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV3-23 Gene

Disorders for IGHV3-23 Gene

Relevant External Links for IGHV3-23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGHV3-23

No disorders were found for IGHV3-23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGHV3-23 Gene

Publications for IGHV3-23 Gene

  1. Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein. (PMID: 7681398) Mariette X. … Brouet J.C. (Eur. J. Immunol. 1993) 3 4 64
  2. Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. (PMID: 3866244) Toyonaga B. … Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 1985) 3 4 64
  3. Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. (PMID: 6450418) Matthyssens G. … Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1980) 3 4 64
  4. Structure of antibodies with shared idiotypy: the complete sequence of the heavy chain variable regions of two immunoglobulin M anti-gamma globulins. (PMID: 4139708) Capra J.D. … Kehoe J.M. (Proc. Natl. Acad. Sci. U.S.A. 1974) 3 4 64
  5. Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions. (PMID: 4522793) Capra J.D. … Kehoe J.M. (Proc. Natl. Acad. Sci. U.S.A. 1974) 3 4 64

Products for IGHV3-23 Gene

Sources for IGHV3-23 Gene

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