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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHV3-23 Gene

protein-coding   GIFtS: 22
GCID: GC14M106729

immunoglobulin heavy variable 3-23
  Search for IGHV3-23
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGHV3-23    

Aliases
for IGHV3-23 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Immunoglobulin Heavy Variable 3-231 2
DP472 5
IGHV3232 5
VH262 5
V3-232

External Ids:    HGNC: 55881   Entrez Gene: 284422   Ensembl: ENSG000002119497   OMIM: 6119395   
ORGUL members:         
NONCODE:n335918 n335884 n334104 n336022 n334751    

Export aliases for IGHV3-23 gene to outside databases

Previous GC identifers: GC14U990198 GC14M104696 GC14M105796 GC14M106726 GC14M086866


Summaries
for IGHV3-23 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IGHV3-23:
IGHV3-23 belongs to a cluster of approximately 40 functional variable (V) genes in the immunoglobulin (Ig) heavy chain
locus on chromosome 14. For background information on the Ig heavy chain and the V gene cluster, see (MIM
147070).(supplied by OMIM, Apr 2008)




Genomic Views
for IGHV3-23 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHV3-23
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHV3-23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHV3-23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHV3-23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHV3-23 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106729:  view genomic region     (about GC identifiers)

Start:
 106,725,199 bp from pter      End:
 106,725,733 bp from pter
Size:
 535 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for IGHV3-23

Proteins
for IGHV3-23 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --
IGHV3-23 Protein expression data from MOPED and PaxDb:    About this image 
IGHV3-23 Protein Expression

ENSEMBL proteins: 
 ENSP00000375018  

Human Recombinant Protein Products for IGHV3-23: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--

IGHV3-23 for ontologies           About GeneDecksing



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Protein Domains /
Families
for IGHV3-23 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for IGHV3-23 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding NAS6450418
     
IGHV3-23 for ontologies           About GeneDecksing


Animal Models:
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miRNA
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In Situ Assay
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Pathways & Interactions
for IGHV3-23 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Immune response_NFAT in immune response
Immune response_NFAT in immune response1.00
2Signal transduction_IP3 signaling
Signal transduction_IP3 signaling1.00
3Immune response_Classical complement pathway
Immune response_Classical complement pathway1.00
4Immune response_IL-4 signaling pathway
Immune response_IL-4 signaling pathway1.00
5Immune response CD16 signaling in NK cells
Immune response_CD16 signaling in NK cells0.99

Pathway sources
See GeneCards unified pathways
Show all pathways


5/7 GeneGo (Thomson Reuters) Pathways for IGHV3-23 (see all 7)
    Immune response IL-4 signaling pathway
Immune response Fc epsilon RI pathway
Immune response CD16 signaling in NK cells
Immune response Classical complement pathway
Immune response BCR pathway


Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHV3-23

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/20 Interacting proteins for IGHV3-23 (ENSP000003750184) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
InteractantInteraction Details
GeneCardExternal ID(s)
B2MENSP000003408584STRING: ENSP00000340858
C1QAENSP000003637734STRING: ENSP00000363773
ENSG00000227715ENSP000004162334STRING: ENSP00000416233
IGHV1-46ENSP000003750314STRING: ENSP00000375031
IGHV7-81ENSP000003750484STRING: ENSP00000375048
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS6450418
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0045087innate immune response TAS--
GO:0050776regulation of immune response TAS--

IGHV3-23 for ontologies           About GeneDecksing



Drugs & Compounds
for IGHV3-23 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHV3-23
Search CenterWatch for drugs/clinical trials and news about IGHV3-23 

Transcripts
for IGHV3-23 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390609

miRNA
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Inhib. RNA
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Clone
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Primer
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GeneLoc Exon Structure


Expression
for IGHV3-23 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHV3-23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
IGHV3-23 Expression
About this image
See IGHV3-23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGHV3-23
    SABiosciences Custom PCR Arrays for IGHV3-23

Primer
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In Situ
Assay Products: 
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Orthologs
for IGHV3-23 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGHV3-23 gene from 3/5 species (see all 5)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves --
--
(see all 23)		 --
 66(a)
64(a)
(see all 23)		 many ↔ many
many ↔ many
(see all 23)		 Un(22188559-22188849)
Un(56284545-56289174)
lizard
(Anolis carolinensis)		 Reptilia --
--
(see all 7)		 --
 43(a)
42(a)
(see all 7)		 possible ortholog
possible ortholog
(see all 7)		 GL344186.1(1657-2132)
GL343491.1(313762-314225)
zebrafish
(Danio rerio)		 Actinopterygii ighv3-26
ighv6-26
(see all 11)		 immunoglobulin heavy variable 6-2
(see all 11)		 50(a)
49(a)
(see all 11)		 many ↔ many
many ↔ many
(see all 11)		 3(34136226-34136659)
3(34160869-34161335)


ENSEMBL Gene Tree for IGHV3-23 (if available)
TreeFam Gene Tree for IGHV3-23 (if available) 

Paralogs
for IGHV3-23 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGHV3-23 gene
IGHV3-432  IGHV3-532  IGHV3-92  IGHV3-212  IGHV3-732  IGHV3-72  IGHV3-302  IGHV3-722  
IGHV3-332  IGHV3-662  IGHV3-112  IGHV3-202  IGHV3-742  IGHV3-162  IGHV3-642  IGHV3-132  
IGHV3-382  IGHV3-152  IGHV3-492  ENSG000002239312  IGHV3-482  IGHV3-352  

IGHV3-23 for paralogs           About GeneDecksing


5/10 Pseudogenes.org Pseudogenes for IGHV3-23 (see all 10)
PGOHUM00000247927 PGOHUM00000262209 PGOHUM00000247950 PGOHUM00000247968 PGOHUM00000247971


Genomic Variants
for IGHV3-23 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHV3-23
DNA2.0 Custom Variant and Variant Library Synthesis for IGHV3-23

Disorders / Diseases
for IGHV3-23 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGHV3-23 for disorders           About MalaCards

IGHV3-23 for disorders           About GeneDecksing

OMIM gene information: 611939    OMIM disorders: --


Export disorders for IGHV3-23 gene to outside databases

Publications
for IGHV3-23 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGHV3-23 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGHV3-23)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  2. Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus. (PubMed id 8490662)1 Matsuda F....Anand R. (1993)
  3. Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein. (PubMed id 7681398)1 Mariette X.... Brouet J.C. (1993)
  4. Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. (PubMed id 3866244)1 Toyonaga B.... Mak T.W. (1985)
  5. Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. (PubMed id 6450418)1 Matthyssens G. and Rabbitts T.H. (1980)
  6. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (1976)
  7. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (1976)

External Searches for IGHV3-23 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGHV3-23 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28442 HGNC: 5588 Ensembl:ENSG00000211949 euGenes: HUgn28442 ECgene: IGHV3-23
H-InvDB: IGHV3-23

Other Databases showing IGHV3-23 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGHV3-23 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGHV3-23 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHV3-23 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGHV3-23 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGHV3-23 gene:
Search GeneIP for patents involving IGHV3-23

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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VWF
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von Willebrand factor
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