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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHV3-21 Gene

protein-coding   GIFtS: 18
GCID: GC14M106997

immunoglobulin heavy variable 3-21
 Explore 3 diseases affiliated with
IGHV3-21 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGHV3-21    

Aliases
for IGHV3-21 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Heavy Variable 3-211 2
IGHV3212
VH2

External Ids:    HGNC: 55861   Entrez Gene: 284442   Ensembl: ENSG000002119477   

Export aliases for IGHV3-21 gene to outside databases

Previous GC identifers: GC14U990200 GC14M104663 GC14M105762 GC14M106693 GC14M086832


Summaries
for IGHV3-21 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGHV3-21 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHV3-21
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHV3-21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHV3-21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHV3-21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHV3-21 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106997:  view genomic region     (about GC identifiers)

Start:
 106,691,671 bp from pter      End:
 106,692,203 bp from pter
Size:
 533 bases      Orientation:
 minus strand

Proteins
for IGHV3-21 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --
IGHV3-21 Protein expression data from MOPED and PaxDb:    About this image 
Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000375016  

Human Recombinant Protein Products: 
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Protein Domains /
Families
for IGHV3-21 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for IGHV3-21 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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Gene Editing
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Clone
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In Situ Assay
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Pathways & Interactions
for IGHV3-21 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHV3-21

Drugs & Compounds
for IGHV3-21 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHV3-21
Search CenterWatch for drugs/clinical trials and news about IGHV3-21 

Transcripts
for IGHV3-21 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390607

miRNA
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Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
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Browse OriGene siRNA
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Clone
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Primer
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  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHV3-21

21 AceView cDNA sequences:

AF035793 AB063691 AF062202 AF062121 AF103077 AB066979 L29155 U77372 
AF103329 AF209735 BG757190 S73912 AW408316 U00508 AY033254 AF460680 
AF408730 AY466506 AF460801 AF158380 AB066976 

GeneLoc Exon Structure


Expression
for IGHV3-21 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHV3-21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See IGHV3-21 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGHV3-21
Primer
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Browse OriGene validated miRNA SYBR primer pairs
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Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHV3-21
In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHV3-21

Orthologs
for IGHV3-21 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGHV3-21 gene from 3/6 species (see all 6)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves --
--
(see all 23)		 --
 64(a)
64(a)
(see all 23)		 many ↔ many
many ↔ many
(see all 23)		 Un(22188559-22188849)
Un(56284545-56289174)
lizard
(Anolis carolinensis)		 Reptilia --
--
(see all 7)		 --
 45(a)
44(a)
(see all 7)		 possible ortholog
possible ortholog
(see all 7)		 GL344186.1(1657-2132)
GL343491.1(313762-314225)
zebrafish
(Danio rerio)		 Actinopterygii ighv14-16
ighv6-26
(see all 11)		 immunoglobulin heavy variable 6-2
(see all 11)		 54(a)
52(a)
(see all 11)		 many ↔ many
many ↔ many
(see all 11)		 3(34112002-34112474)
3(34160869-34161335)


ENSEMBL Gene Tree for IGHV3-21 (if available)
TreeFam Gene Tree for IGHV3-21 (if available) 

Paralogs
for IGHV3-21 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGHV3-21 gene
IGHV3-432  IGHV3-532  IGHV3-92  IGHV3-732  IGHV3-72  IGHV3-302  IGHV3-232  IGHV3-722  
IGHV3-332  IGHV3-662  IGHV3-112  IGHV3-202  IGHV3-742  IGHV3-162  IGHV3-642  IGHV3-132  
IGHV3-382  IGHV3-152  IGHV3-492  ENSG000002239312  IGHV3-482  IGHV3-352  

IGHV3-21 for paralogs           About GeneDecksing



Genomic Variants
for IGHV3-21 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHV3-21
DNA2.0 Custom Variant and Variant Library Synthesis for IGHV3-21

Disorders / Diseases
for IGHV3-21 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGHV3-21 for disorders           About GeneDecksing

3 diseases for IGHV3-21:    About MalaCards
chronic lymphocytic leukemia    lymphocytic leukemia    leukemia

1 disease from the University of Copenhagen DISEASES database for IGHV3-21:
Chronic lymphocytic leukemia
Human Genome Epidemiology (HuGE) Navigator: IGHV3-21 (2 documents)

Export disorders for IGHV3-21 gene to outside databases

Publications
for IGHV3-21 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGHV3-21 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGHV3-21)		    Utopia: connect your pdf to the dynamic
world of online information

  1. IGHV3-21 gene frequency in a Swedish cohort of patient s with newly diagnosed chronic lymphocytic leukemia. (PubMed id 22464020)1 Cahill N....Rosenquist R. (2012)
  2. Analyses of recombinant stereotypic IGHV3-21-encoded antibodies expressed in chronic lymphocytic leukemia. (PubMed id 21525382)1 Ghia E.M....Kipps T.J. (2011)
  3. Prognostic factors identify 3 risk groups in the LRF CLL4 trial, independent of treatment allocation. (PubMed id 20511662)1 Oscier D....Catovsky D. (2010)
  4. Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study. (PubMed id 17148579)1 Bomben R....Gattei V. (2007)
  5. IGHV3-21 gene expression in patients with B-cell chronic lymphocytic leukemia in Ukraine. (PubMed id 18004251)1 Abramenko I....Bebeshko V. (2007)
  6. Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. (PubMed id 15466924)1 Ghia P....Davi F. (2005)
  7. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. (PubMed id 9841928)1 Matsuda F....Honjo T. (1998)
  8. The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. (PubMed id 1404388)1 Tomlinson I.M....Winter G. (1992)

External Searches for IGHV3-21 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGHV3-21 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28444 HGNC: 5586 AceView: IGHV3-21 Ensembl:ENSG00000211947 euGenes: HUgn28444
ECgene: IGHV3-21 H-InvDB: IGHV3-21

Other Databases showing IGHV3-21 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGHV3-21 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGHV3-21 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHV3-21 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGHV3-21 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGHV3-21 gene:
Search GeneIP for patents involving IGHV3-21

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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