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Aliases for IGHV3-21 Gene

Aliases for IGHV3-21 Gene

  • Immunoglobulin Heavy Variable 3-21 2 3 5
  • Immunogloblin Heavy Chain Variable Region 3
  • IGHV321 3
  • VH 3

External Ids for IGHV3-21 Gene

Previous GeneCards Identifiers for IGHV3-21 Gene

  • GC14U990200
  • GC14M104663
  • GC14M105762
  • GC14M106693
  • GC14M086832
  • GC14M106997
  • GC14M107429
  • GC14M107621
  • GC14M106236

Summaries for IGHV3-21 Gene

GeneCards Summary for IGHV3-21 Gene

IGHV3-21 (Immunoglobulin Heavy Variable 3-21) is a Protein Coding gene. Diseases associated with IGHV3-21 include Chronic Lymphocytic Leukemia. An important paralog of this gene is IGHV3-48.

UniProtKB/Swiss-Prot for IGHV3-21 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV3-21 Gene

Genomics for IGHV3-21 Gene

Regulatory Elements for IGHV3-21 Gene

Enhancers for IGHV3-21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F106234 1.1 Ensembl ENCODE 0.8 -0.2 -201 2.4 CTCF STAT1 SMAD5 CBFB ZBED1 CHD4 CHD1 TRIM22 GLIS2 POLR2A IGHV3-19 ENSG00000211974 IGHV3-21 IGHV3-22
GH14F106227 0.9 Ensembl ENCODE 0.4 +7.1 7050 1.9 IGHV3-19 IGHV3-21 ENSG00000283693
GH14F106229 1.3 Ensembl ENCODE 0.4 +5.5 5472 0.3 SCRT1 SCRT2 IGHV3-19 ENSG00000283693 IGHV3-21
GH14F106223 1 Ensembl ENCODE 0.4 +11.3 11305 1.4 CTCF IGHV3-19 ENSG00000283693 IGHV3-21
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGHV3-21 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHV3-21 Gene

Chromosome:
14
Start:
106,235,062 bp from pter
End:
106,235,594 bp from pter
Size:
533 bases
Orientation:
Minus strand

Genomic View for IGHV3-21 Gene

Genes around IGHV3-21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV3-21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV3-21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV3-21 Gene

Proteins for IGHV3-21 Gene

  • Protein details for IGHV3-21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0B4J1V1-HV321_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 3-21
    Protein Accession:
    A0A0B4J1V1

    Protein attributes for IGHV3-21 Gene

    Size:
    117 amino acids
    Molecular mass:
    12840 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

neXtProt entry for IGHV3-21 Gene

Post-translational modifications for IGHV3-21 Gene

No Post-translational modifications

Other Protein References for IGHV3-21 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV3-21 Gene

Domains & Families for IGHV3-21 Gene

Gene Families for IGHV3-21 Gene

Protein Domains for IGHV3-21 Gene

Graphical View of Domain Structure for InterPro Entry

A0A0B4J1V1

UniProtKB/Swiss-Prot:

HV321_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGHV3-21: view

No data available for Suggested Antigen Peptide Sequences for IGHV3-21 Gene

Function for IGHV3-21 Gene

Molecular function for IGHV3-21 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV3-21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGHV3-21: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV3-21 Gene

Localization for IGHV3-21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV3-21 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV3-21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGHV3-21: view

No data available for Subcellular locations from COMPARTMENTS for IGHV3-21 Gene

Pathways & Interactions for IGHV3-21 Gene

SuperPathways for IGHV3-21 Gene

No Data Available

Interacting Proteins for IGHV3-21 Gene

Gene Ontology (GO) - Biological Process for IGHV3-21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IGHV3-21: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV3-21 Gene

Transcripts for IGHV3-21 Gene

mRNA/cDNA for IGHV3-21 Gene

(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV3-21 Gene

No ASD Table

Relevant External Links for IGHV3-21 Gene

GeneLoc Exon Structure for
IGHV3-21
ECgene alternative splicing isoforms for
IGHV3-21

Expression for IGHV3-21 Gene

mRNA expression in normal human tissues for IGHV3-21 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV3-21 Gene

This gene is overexpressed in Spleen (x12.6), Colon - Transverse (x7.6), and Whole Blood (x6.2).

Protein differential expression in normal tissues from HIPED for IGHV3-21 Gene

This gene is overexpressed in Saliva (27.3), Serum (24.0), and Urine (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHV3-21 Gene



Protein tissue co-expression partners for IGHV3-21 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGHV3-21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHV3-21 Gene

Orthologs for IGHV3-21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGHV3-21 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 71 (a)
ManyToMany
Species where no ortholog for IGHV3-21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGHV3-21 Gene

ENSEMBL:
Gene Tree for IGHV3-21 (if available)
TreeFam:
Gene Tree for IGHV3-21 (if available)

Paralogs for IGHV3-21 Gene

Variants for IGHV3-21 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV3-21 Gene

HV321_HUMAN-A0A0B4J1V1
There are several alleles. The sequence shown is that of IMGT allele IGHV3-21*01, IMGT allele IGHV3-21*02, IMGT allele IGHV3-21*03 and IMGT allele IGHV3-21*04.

Relevant External Links for IGHV3-21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV3-21

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV3-21 Gene

Disorders for IGHV3-21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGHV3-21 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGHV3-21

Genetic Association Database (GAD)
IGHV3-21
Human Genome Epidemiology (HuGE) Navigator
IGHV3-21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGHV3-21
genes like me logo Genes that share disorders with IGHV3-21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGHV3-21 Gene

Publications for IGHV3-21 Gene

  1. Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation. (PMID: 20511662) Oscier D. … Catovsky D. (Haematologica 2010) 3 46 64
  2. Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations. (PMID: 25634617) Baliakas P. … Stamatopoulos K. (Blood 2015) 3 64
  3. IGHV3-21 gene frequency in a Swedish cohort of patients with newly diagnosed chronic lymphocytic leukemia. (PMID: 22464020) Cahill N. … Rosenquist R. (Clin Lymphoma Myeloma Leuk 2012) 3 64
  4. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  5. Analyses of recombinant stereotypic IGHV3-21-encoded antibodies expressed in chronic lymphocytic leukemia. (PMID: 21525382) Ghia E.M. … Kipps T.J. (J. Immunol. 2011) 3 64

Products for IGHV3-21 Gene

Sources for IGHV3-21 Gene

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