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Aliases for IGHV3-21 Gene

Aliases for IGHV3-21 Gene

  • Immunoglobulin Heavy Variable 3-21 2 3 5
  • Immunogloblin Heavy Chain Variable Region 3
  • IGHV321 3
  • VH 3

External Ids for IGHV3-21 Gene

Previous GeneCards Identifiers for IGHV3-21 Gene

  • GC14U990200
  • GC14M104663
  • GC14M105762
  • GC14M106693
  • GC14M086832
  • GC14M106997
  • GC14M107429
  • GC14M107621

Summaries for IGHV3-21 Gene

GeneCards Summary for IGHV3-21 Gene

IGHV3-21 (Immunoglobulin Heavy Variable 3-21) is a Protein Coding gene. Diseases associated with IGHV3-21 include Chronic Lymphocytic Leukemia. An important paralog of this gene is IGHV3-48.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV3-21 Gene

Genomics for IGHV3-21 Gene

Regulatory Elements for IGHV3-21 Gene

Enhancers for IGHV3-21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around IGHV3-21 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHV3-21 Gene

106,235,062 bp from pter
106,235,594 bp from pter
533 bases
Minus strand

Genomic View for IGHV3-21 Gene

Genes around IGHV3-21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV3-21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV3-21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV3-21 Gene

Proteins for IGHV3-21 Gene

  • Protein details for IGHV3-21 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein IGHV3-21
    Protein Accession:

    Protein attributes for IGHV3-21 Gene

    117 amino acids
    Molecular mass:
    12840 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGHV3-21 Gene

Post-translational modifications for IGHV3-21 Gene

No Post-translational modifications

Other Protein References for IGHV3-21 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV3-21 Gene

Domains & Families for IGHV3-21 Gene

Gene Families for IGHV3-21 Gene

Protein Domains for IGHV3-21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV3-21: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV3-21 Gene

Function for IGHV3-21 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV3-21 Gene

Localization for IGHV3-21 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IGHV3-21 Gene

Pathways & Interactions for IGHV3-21 Gene

SuperPathways for IGHV3-21 Gene

No Data Available

Interacting Proteins for IGHV3-21 Gene

Gene Ontology (GO) - Biological Process for IGHV3-21 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGHV3-21 Gene

Drugs & Compounds for IGHV3-21 Gene

No Compound Related Data Available

Transcripts for IGHV3-21 Gene

mRNA/cDNA for IGHV3-21 Gene

(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV3-21 Gene

No ASD Table

Relevant External Links for IGHV3-21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHV3-21 Gene

mRNA expression in normal human tissues for IGHV3-21 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV3-21 Gene

This gene is overexpressed in Spleen (x12.6), Colon - Transverse (x7.6), and Whole Blood (x6.2).

Protein differential expression in normal tissues from HIPED for IGHV3-21 Gene

This gene is overexpressed in Saliva (27.3), Serum (24.0), and Urine (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for IGHV3-21 Gene

Protein tissue co-expression partners for IGHV3-21 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGHV3-21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHV3-21 Gene

Orthologs for IGHV3-21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGHV3-21 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia -- 35
  • 71 (a)
Species where no ortholog for IGHV3-21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGHV3-21 Gene

Gene Tree for IGHV3-21 (if available)
Gene Tree for IGHV3-21 (if available)

Paralogs for IGHV3-21 Gene

genes like me logo Genes that share paralogs with IGHV3-21: view

Variants for IGHV3-21 Gene

Relevant External Links for IGHV3-21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV3-21 Gene

Disorders for IGHV3-21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGHV3-21 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • b-cell chronic lymphocytic leukemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGHV3-21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGHV3-21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGHV3-21 Gene

Publications for IGHV3-21 Gene

  1. Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation. (PMID: 20511662) Oscier D. … Catovsky D. (Haematologica 2010) 3 46 65
  2. Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations. (PMID: 25634617) Baliakas P. … Stamatopoulos K. (Blood 2015) 3 65
  3. IGHV3-21 gene frequency in a Swedish cohort of patients with newly diagnosed chronic lymphocytic leukemia. (PMID: 22464020) Cahill N. … Rosenquist R. (Clin Lymphoma Myeloma Leuk 2012) 3 65
  4. Analyses of recombinant stereotypic IGHV3-21-encoded antibodies expressed in chronic lymphocytic leukemia. (PMID: 21525382) Ghia E.M. … Kipps T.J. (J. Immunol. 2011) 3 65
  5. Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study. (PMID: 17148579) Bomben R. … Gattei V. (Blood 2007) 3 65

Products for IGHV3-21 Gene

Sources for IGHV3-21 Gene

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