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Aliases for IGHV2-70 Gene

Aliases for IGHV2-70 Gene

  • Immunoglobulin Heavy Variable 2-70 2 3
  • Immunogloblin Heavy Chain Variable Region 3
  • Ig Heavy Chain V-II Region 3
  • IGHV270 3
  • VH 3

External Ids for IGHV2-70 Gene

Previous GeneCards Identifiers for IGHV2-70 Gene

  • GC14U990210
  • GC14M105150
  • GC14M106249
  • GC14M107179
  • GC14M107220
  • GC14M107356
  • GC14M107512
  • GC14M107704

Summaries for IGHV2-70 Gene

GeneCards Summary for IGHV2-70 Gene

IGHV2-70 (Immunoglobulin Heavy Variable 2-70) is a Protein Coding gene. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHV4-31.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV2-70 Gene

Genomics for IGHV2-70 Gene

Genomic Location for IGHV2-70 Gene

106,770,577 bp from pter
106,771,020 bp from pter
444 bases
Minus strand

Genomic View for IGHV2-70 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGHV2-70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV2-70 Gene

No data available for Regulatory Elements for IGHV2-70 Gene

Proteins for IGHV2-70 Gene

  • Protein details for IGHV2-70 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein IGHV2-70
    Protein Accession:
    Secondary Accessions:

    Protein attributes for IGHV2-70 Gene

    119 amino acids
    Molecular mass:
    13312 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGHV2-70 Gene

Proteomics data for IGHV2-70 Gene at MOPED

Post-translational modifications for IGHV2-70 Gene

No Post-translational modifications

Other Protein References for IGHV2-70 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV2-70 Gene

Domains for IGHV2-70 Gene

Gene Families for IGHV2-70 Gene

Protein Domains for IGHV2-70 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV2-70: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV2-70 Gene

Function for IGHV2-70 Gene

Gene Ontology (GO) - Molecular Function for IGHV2-70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 5449120
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGHV2-70: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV2-70 Gene

Localization for IGHV2-70 Gene

Subcellular locations from

Jensen Localization Image for IGHV2-70 Gene COMPARTMENTS Subcellular localization image for IGHV2-70 gene
Compartment Confidence
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IGHV2-70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with IGHV2-70: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IGHV2-70 Gene

Pathways for IGHV2-70 Gene

genes like me logo Genes that share pathways with IGHV2-70: view

Interacting Proteins for IGHV2-70 Gene

Gene Ontology (GO) - Biological Process for IGHV2-70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 5449120
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with IGHV2-70: view

Transcripts for IGHV2-70 Gene

mRNA/cDNA for IGHV2-70 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV2-70 Gene

No ASD Table

Relevant External Links for IGHV2-70 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHV2-70 Gene

mRNA expression in normal human tissues for IGHV2-70 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV2-70 Gene

This gene is overexpressed in Spleen (18.1), Minor Salivary Gland (7.0), and Colon - Transverse (5.1).
genes like me logo Genes that share expressions with IGHV2-70: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for IGHV2-70 Gene

Orthologs for IGHV2-70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHV2-70 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
(Gallus gallus)
Aves -- 36
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
(Danio rerio)
Actinopterygii ighv5-1 36
  • 39 (a)
ighv5-2 36
  • 40 (a)
ighv5-3 36
  • 36 (a)
ighv5-4 36
  • 40 (a)
ighv5-5 36
  • 40 (a)
ighv5-7 36
  • 39 (a)
ighv5-8 36
  • 40 (a)
ighv7-1 36
  • 33 (a)
ighv8-1 36
  • 34 (a)
ighv8-2 36
  • 37 (a)
ighv8-3 36
  • 35 (a)
ighv8-4 36
  • 36 (a)
Species with no ortholog for IGHV2-70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHV2-70 Gene

Gene Tree for IGHV2-70 (if available)
Gene Tree for IGHV2-70 (if available)

Paralogs for IGHV2-70 Gene

genes like me logo Genes that share paralogs with IGHV2-70: view

Variants for IGHV2-70 Gene

Relevant External Links for IGHV2-70 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGHV2-70 Gene

Disorders for IGHV2-70 Gene

No disorders were found for IGHV2-70 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for IGHV2-70 Gene

Publications for IGHV2-70 Gene

  1. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PMID: 814163) Ziccardi R.J. … Cooper N.R. (J. Immunol. 1976) 3
  2. The amino acid sequences of the Fd fragments of two human gamma-1 heavy chains. (PMID: 5449120) Press E.M. … Hogg N.M. (Biochem. J. 1970) 3
  3. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. (PMID: 9841928) Matsuda F. … Honjo T. (J. Exp. Med. 1998) 3
  4. Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S. … Sun P. (Mol. Immunol. 2002) 3
  5. Molecular characterization of human antibodies to bacterial antigens: utilization of the less frequently expressed VH2 and VH6 heavy chain variable region gene families. (PMID: 8247031) Andris J.S. … Capra J.D. (Mol. Immunol. 1993) 3

Products for IGHV2-70 Gene

Sources for IGHV2-70 Gene

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