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IGHV2-70 Gene

protein-coding   GIFtS: 19
GCID: GC14M107704

Immunoglobulin Heavy Variable 2-70

  Search for IGHV2-70
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Heavy Variable 2-701 2
IGHV2702
VH2

External Ids:    HGNC: 55771   Entrez Gene: 284542   Ensembl: ENSG000002119747   

Export aliases for IGHV2-70 gene to outside databases

Previous GC identifers: GC14U990210 GC14M105150 GC14M106249 GC14M107179 GC14M107220 GC14M107356 GC14M107512


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGHV2-70 Gene:
IGHV2-70 (immunoglobulin heavy variable 2-70) is a protein-coding gene. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHV4-4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IGHV2-70
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGHV2-70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHV2-70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHV2-70 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M107704:  view genomic region     (about GC identifiers)

Start:
107,178,819 bp from pter      End:
107,179,338 bp from pter
Size:
520 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB: --
Explore proteomics data for IGHV2-70 at MOPED


See IGHV2-70 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000375043  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IGH: Immunoglobulins / IGH locus

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding NAS5449120
GO:0005515protein binding ----
     
IGHV2-70 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
cytosol1
lysosome1
mitochondrion1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--

IGHV2-70 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IGHV2-70 About   (see all 8)  
See pathways by source

SuperPathContained pathways About
1Creation of C4 and C2 activators
Creation of C4 and C2 activators0.85
FCGR activation0.54
Initial triggering of complement0.85
Role of phospholipids in phagocytosis0.53
Classical antibody-mediated complement activation0.82
FCERI mediated NF-kB activation0.32
Complement cascade0.68
2Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
FCERI mediated Ca+2 mobilization0.47
FCERI mediated MAPK activation0.45
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.47
3Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation0.77
Fcgamma receptor (FCGR) dependent phagocytosis0.77
4PI-3K cascade
Role of LAT2/NTAL/LAB on calcium mobilization0.80
Fc epsilon receptor (FCERI) signaling0.64
5Binding and Uptake of Ligands by Scavenger Receptors
Binding and Uptake of Ligands by Scavenger Receptors0.53
Scavenging of Heme from Plasma0.53



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Interactions:

    Search GeneGlobe Interaction Network for IGHV2-70

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for IGHV2-70 (ENSP000003750434) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IGLC2ENSP000003748564STRING: ENSP00000374856
IGKCENSP000003747774STRING: ENSP00000374777
About this table

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS5449120
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0038095Fc-epsilon receptor signaling pathway TAS--
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--

IGHV2-70 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for IGHV2-70



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390634
miRNA
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Selected AceView cDNA sequences (see all 36):

AF062153 AY190826 AB067220 AF062247 AB067191 AY393293 U00575 AB067209 
AF174117 AB066848 AB067197 AB067230 AB067187 AB067205 AB066856 AB067210 
AY393434 AB066860 BF359322 AB066875 AF103042 AB067188 AB067211 AB066855 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IGHV2-70 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGHV2-70 Expression
About this image

IGHV2-70 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IGHV2-70 Protein Expression
    Custom PCR Arrays for IGHV2-70
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHV2-70

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IGHV2-70 gene from 4 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
platypus
(Ornithorhynchus anatinus)
Mammalia --
Uncharacterized protein
36(a)
many ↔ many
4(21938301-21938986)
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
29(a)
1 → many
10(113472-115609)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
55(a)
1 → many
GL343491.1(338024-338480)
zebrafish
(Danio rerio)
Actinopterygii ighv5-46
ighv5-56
(see all 12)
immunoglobulin heavy variable 5-5
(see all 12)
40(a)
40(a)
(see all 12)
many ↔ many
many ↔ many
(see all 12)
3(34180056-34180517) ENSDARG00000096308
3(34174148-34174606) ENSDARG00000096342


ENSEMBL Gene Tree for IGHV2-70 (if available)
TreeFam Gene Tree for IGHV2-70 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IGHV2-70 gene
IGHV4-42  IGHV2-262  IGHV2-52  IGHV4-612  IGHV4-392  IGHV2OR16-52  IGHV4-282  IGHV4-592  
IGHV6-12  IGHV4OR15-82  IGHV4-312  IGHV4-342  

IGHV2-70 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGHV2-70
DNA2.0 Custom Variant and Variant Library Synthesis for IGHV2-70

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IGHV2-70 gene integrated from 10 sources:
(articles sorted by number of sources associating them with IGHV2-70)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (Mol. Immunol. 2002)
  2. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. (PubMed id 9841928)1 Matsuda F....Honjo T. (J. Exp. Med. 1998)
  3. Molecular characterization of human antibodies to bacterial antigens: utilization of the less frequently expressed VH2 and VH6 heavy chain variable region gene families. (PubMed id 8247031)1 Andris J.S....Capra J.D. (Mol. Immunol. 1993)
  4. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (J. Immunol. 1976)
  5. The amino acid sequences of the Fd fragments of two human gamma-1 heavy chains. (PubMed id 5449120)1 Press E.M. and Hogg N.M. (Biochem. J. 1970)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 28454 HGNC: 5577 AceView: IGHV2-70 Ensembl:ENSG00000211974 euGenes: HUgn28454
ECgene: IGHV2-70 H-InvDB: IGHV2-70

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IGHV2-70 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHV2-70 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IGHV2-70 gene:
Search GeneIP for patents involving IGHV2-70

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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