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Aliases for IGHV2-70 Gene

Aliases for IGHV2-70 Gene

  • Immunoglobulin Heavy Variable 2-70 2 3 5
  • Ig Heavy Chain V-II Region OU 3 4
  • Immunogloblin Heavy Chain Variable Region 3
  • Ig Heavy Chain V-II Region SESS 4
  • Ig Heavy Chain V-II Region COR 4
  • Ig Heavy Chain V-II Region DAW 4
  • Ig Heavy Chain V-II Region 3
  • IGHV270 3
  • VH 3

External Ids for IGHV2-70 Gene

Previous GeneCards Identifiers for IGHV2-70 Gene

  • GC14U990210
  • GC14M105150
  • GC14M106249
  • GC14M107179
  • GC14M107220
  • GC14M107356
  • GC14M107512
  • GC14M107704
  • GC14M107002
  • GC14M107744
  • GC14M107837
  • GC14M107936

Summaries for IGHV2-70 Gene

GeneCards Summary for IGHV2-70 Gene

IGHV2-70 (Immunoglobulin Heavy Variable 2-70) is a Protein Coding gene. GO annotations related to this gene include antigen binding. An important paralog of this gene is ENSG00000211974.

UniProtKB/Swiss-Prot for IGHV2-70 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV2-70 Gene

Genomics for IGHV2-70 Gene

Regulatory Elements for IGHV2-70 Gene

Enhancers for IGHV2-70 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F106769 0.9 Ensembl ENCODE 0.8 +0.8 842 2.6 ZFHX2 MTA2 TCF7 JUNB SMAD4 BCL6 CREM RARA IGHV1-69 ENSG00000211974 IGHV3-66 GC14M108051 IGHV2-70
GH14F106774 0.8 Ensembl ENCODE 0.8 -4.2 -4172 0.4 CTCF ZNF143 TRIM22 ZNF2 IGHV1-69 IGHV3-66 ENSG00000211974 IGHV2-70 IGHV3-71
GH14F106768 0.4 ENCODE 0.8 +2.4 2417 0.1 TCF7 IGHV3-66 GC14M108051 IGHV2-70
GH14F106775 0.2 ENCODE 0.8 -3.6 -3637 0.2 IGHV1-69 IGHV2-70 IGHV3-71
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGHV2-70 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHV2-70 Gene

Chromosome:
14
Start:
106,770,577 bp from pter
End:
106,771,020 bp from pter
Size:
444 bases
Orientation:
Minus strand

Genomic View for IGHV2-70 Gene

Genes around IGHV2-70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV2-70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV2-70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV2-70 Gene

Proteins for IGHV2-70 Gene

  • Protein details for IGHV2-70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01814-HV270_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 2-70
    Protein Accession:
    P01814
    Secondary Accessions:
    • A0A0B4J2H3
    • P01815
    • P01816
    • P04438

    Protein attributes for IGHV2-70 Gene

    Size:
    119 amino acids
    Molecular mass:
    13260 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

neXtProt entry for IGHV2-70 Gene

Post-translational modifications for IGHV2-70 Gene

No Post-translational modifications

Other Protein References for IGHV2-70 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV2-70 Gene

Domains & Families for IGHV2-70 Gene

Gene Families for IGHV2-70 Gene

Protein Domains for IGHV2-70 Gene

Graphical View of Domain Structure for InterPro Entry

P01814

UniProtKB/Swiss-Prot:

HV270_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGHV2-70: view

No data available for Suggested Antigen Peptide Sequences for IGHV2-70 Gene

Function for IGHV2-70 Gene

Molecular function for IGHV2-70 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV2-70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 4742735
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGHV2-70: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV2-70 Gene

Localization for IGHV2-70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV2-70 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV2-70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGHV2-70: view

No data available for Subcellular locations from COMPARTMENTS for IGHV2-70 Gene

Pathways & Interactions for IGHV2-70 Gene

SuperPathways for IGHV2-70 Gene

No Data Available

Interacting Proteins for IGHV2-70 Gene

Gene Ontology (GO) - Biological Process for IGHV2-70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 4742735
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGHV2-70: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV2-70 Gene

Transcripts for IGHV2-70 Gene

mRNA/cDNA for IGHV2-70 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV2-70 Gene

No ASD Table

Relevant External Links for IGHV2-70 Gene

GeneLoc Exon Structure for
IGHV2-70
ECgene alternative splicing isoforms for
IGHV2-70

Expression for IGHV2-70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGHV2-70 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV2-70 Gene

This gene is overexpressed in Spleen (x18.1), Minor Salivary Gland (x7.0), and Colon - Transverse (x5.1).
genes like me logo Genes that share expression patterns with IGHV2-70: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IGHV2-70 Gene

Orthologs for IGHV2-70 Gene

Evolution for IGHV2-70 Gene

ENSEMBL:
Gene Tree for IGHV2-70 (if available)
TreeFam:
Gene Tree for IGHV2-70 (if available)

No data available for Orthologs for IGHV2-70 Gene

Paralogs for IGHV2-70 Gene

Variants for IGHV2-70 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV2-70 Gene

HV270_HUMAN-P01814
There are several alleles. The sequence shown is that of IMGT allele IGHV2-70*01.

Relevant External Links for IGHV2-70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV2-70

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV2-70 Gene

Disorders for IGHV2-70 Gene

No disorders were found for IGHV2-70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV2-70 Gene

Publications for IGHV2-70 Gene

  1. Rearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining region. (PMID: 6089186) Takahashi N. … Honjo T. (Proc. Natl. Acad. Sci. U.S.A. 1984) 3 4 64
  2. Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin. (PMID: 4742735) Putnam F.W. … Shimizu A. (Science 1973) 3 4 64
  3. The amino acid sequences of the Fd fragments of two human gamma-1 heavy chains. (PMID: 5449120) Press E.M. … Hogg N.M. (Biochem. J. 1970) 3 4 64
  4. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  5. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64

Products for IGHV2-70 Gene

Sources for IGHV2-70 Gene

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