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Aliases for IGHV2-5 Gene

Aliases for IGHV2-5 Gene

  • Immunoglobulin Heavy Variable 2-5 2 3 5
  • Ig Heavy Chain V-II Region MCE 3 4
  • Ig Heavy Chain V-II Region HE 3 4
  • Immunogloblin Heavy Chain Variable Region 3
  • Ig Heavy Chain V-II Region 5 3
  • IGHV25 3
  • VH 3

External Ids for IGHV2-5 Gene

Previous GeneCards Identifiers for IGHV2-5 Gene

  • GC14U990213
  • GC14M104465
  • GC14M105565
  • GC14M106496
  • GC14M086635
  • GC14M106551
  • GC14M106760
  • GC14M107408
  • GC14M107600

Summaries for IGHV2-5 Gene

GeneCards Summary for IGHV2-5 Gene

IGHV2-5 (Immunoglobulin Heavy Variable 2-5) is a Protein Coding gene. An important paralog of this gene is ENSG00000211974.

UniProtKB/Swiss-Prot for IGHV2-5 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Additional gene information for IGHV2-5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV2-5 Gene

Genomics for IGHV2-5 Gene

Genomic Location for IGHV2-5 Gene

Chromosome:
14
Start:
106,037,902 bp from pter
End:
106,038,365 bp from pter
Size:
464 bases
Orientation:
Minus strand

Genomic View for IGHV2-5 Gene

Genes around IGHV2-5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV2-5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV2-5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV2-5 Gene

No data available for Regulatory Elements for IGHV2-5 Gene

Proteins for IGHV2-5 Gene

  • Protein details for IGHV2-5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01817-HV205_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 2-5
    Protein Accession:
    P01817
    Secondary Accessions:
    • A0A0A0MS10
    • P01818

    Protein attributes for IGHV2-5 Gene

    Size:
    119 amino acids
    Molecular mass:
    13231 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGHV2-5 Gene

Post-translational modifications for IGHV2-5 Gene

No Post-translational modifications

Other Protein References for IGHV2-5 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV2-5 Gene

Domains & Families for IGHV2-5 Gene

Gene Families for IGHV2-5 Gene

Protein Domains for IGHV2-5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV2-5: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV2-5 Gene

Function for IGHV2-5 Gene

Molecular function for IGHV2-5 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV2-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 5264153
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGHV2-5: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGHV2-5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV2-5 Gene

Localization for IGHV2-5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV2-5 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV2-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGHV2-5: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGHV2-5 Gene

Pathways & Interactions for IGHV2-5 Gene

SuperPathways for IGHV2-5 Gene

No Data Available

Interacting Proteins for IGHV2-5 Gene

Gene Ontology (GO) - Biological Process for IGHV2-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 5264153
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGHV2-5: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV2-5 Gene

Drugs & Compounds for IGHV2-5 Gene

No Compound Related Data Available

Transcripts for IGHV2-5 Gene

mRNA/cDNA for IGHV2-5 Gene

(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGHV2-5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV2-5 Gene

No ASD Table

Relevant External Links for IGHV2-5 Gene

GeneLoc Exon Structure for
IGHV2-5
ECgene alternative splicing isoforms for
IGHV2-5

Expression for IGHV2-5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGHV2-5 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV2-5 Gene

This gene is overexpressed in Spleen (x10.7), Colon - Transverse (x7.8), Small Intestine - Terminal Ileum (x6.0), and Minor Salivary Gland (x5.7).
genes like me logo Genes that share expression patterns with IGHV2-5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV2-5 Gene

Orthologs for IGHV2-5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHV2-5 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ighv5-7 34
  • 41 (a)
ManyToMany
ighv5-2 34
  • 40 (a)
ManyToMany
ighv5-1 34
  • 39 (a)
ManyToMany
ighv5-5 34
  • 38 (a)
ManyToMany
ighv5-3 34
  • 37 (a)
ManyToMany
ighv5-4 34
  • 37 (a)
ManyToMany
ighv5-8 34
  • 36 (a)
ManyToMany
ighv8-4 34
  • 36 (a)
ManyToMany
ighv8-2 34
  • 35 (a)
ManyToMany
ighv8-1 34
  • 34 (a)
ManyToMany
ighv8-3 34
  • 34 (a)
ManyToMany
ighv7-1 34
  • 32 (a)
ManyToMany
Species where no ortholog for IGHV2-5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHV2-5 Gene

ENSEMBL:
Gene Tree for IGHV2-5 (if available)
TreeFam:
Gene Tree for IGHV2-5 (if available)

Paralogs for IGHV2-5 Gene

Variants for IGHV2-5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV2-5 Gene

HV205_HUMAN-P01817
There are several alleles. The sequence shown is that of IMGT allele IGHV2-5*02.

Relevant External Links for IGHV2-5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV2-5

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV2-5 Gene

Disorders for IGHV2-5 Gene

No disorders were found for IGHV2-5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV2-5 Gene

Publications for IGHV2-5 Gene

  1. Molecular basis for the temperature-dependent insolubility of cryoglobulins. X. The amino acid sequence of the heavy chain variable region of McE. (PMID: 6780622) Gerber-Jenson B … Litman GW (Journal of immunology (Baltimore, Md. : 1950) 1981) 3 4 60
  2. Subgroups of amino acid sequences in the variable regions of immunoglobulin heavy chains. (PMID: 5264153) Cunningham BA … Edelman GM (Proceedings of the National Academy of Sciences of the United States of America 1969) 3 4 60
  3. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 60
  4. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 60
  5. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 60

Products for IGHV2-5 Gene

Sources for IGHV2-5 Gene

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