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Aliases for IGHV2-26 Gene

Aliases for IGHV2-26 Gene

  • Immunoglobulin Heavy Variable 2-26 2 3 5
  • Immunogloblin Heavy Chain Variable Region 3
  • IGHV226 3
  • VH 3

External Ids for IGHV2-26 Gene

Previous GeneCards Identifiers for IGHV2-26 Gene

  • GC14U990211
  • GC14M104729
  • GC14M105828
  • GC14M106758
  • GC14M086898
  • GC14M106768
  • GC14M107437
  • GC14M107629

Summaries for IGHV2-26 Gene

GeneCards Summary for IGHV2-26 Gene

IGHV2-26 (Immunoglobulin Heavy Variable 2-26) is a Protein Coding gene. An important paralog of this gene is IGHV2OR16-5.

UniProtKB/Swiss-Prot for IGHV2-26 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV2-26 Gene

Genomics for IGHV2-26 Gene

Regulatory Elements for IGHV2-26 Gene

Enhancers for IGHV2-26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F106302 0.4 ENCODE 0.8 +0.5 501 0.2 ZNF512 IGHV2-26 IGHVIII-25-1
GH14F106308 0.8 ENCODE 0.4 -7.1 -7113 0.2 CTCF PKNOX1 SUZ12 IRF3 RAD21 RELA CBX5 POLR2A ZNF143 SMC3 GC14M106310 IGHV2-26
GH14F106309 0.8 ENCODE 0.4 -7.3 -7313 0.2 CTCF PKNOX1 SUZ12 IRF3 RAD21 RELA CBX5 POLR2A ZNF143 SMC3 GC14M106310 IGHV2-26
GH14F106301 0.2 ENCODE 0.8 +0.7 681 0.2 IGHV2-26 IGHVIII-25-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGHV2-26 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHV2-26 Gene

Chromosome:
14
Start:
106,301,395 bp from pter
End:
106,301,862 bp from pter
Size:
468 bases
Orientation:
Minus strand

Genomic View for IGHV2-26 Gene

Genes around IGHV2-26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV2-26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV2-26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV2-26 Gene

Proteins for IGHV2-26 Gene

  • Protein details for IGHV2-26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0B4J1V2-HV226_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 2-26
    Protein Accession:
    A0A0B4J1V2

    Protein attributes for IGHV2-26 Gene

    Size:
    119 amino acids
    Molecular mass:
    13182 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

neXtProt entry for IGHV2-26 Gene

Post-translational modifications for IGHV2-26 Gene

No Post-translational modifications

Other Protein References for IGHV2-26 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV2-26 Gene

Domains & Families for IGHV2-26 Gene

Gene Families for IGHV2-26 Gene

Protein Domains for IGHV2-26 Gene

Graphical View of Domain Structure for InterPro Entry

A0A0B4J1V2

UniProtKB/Swiss-Prot:

HV226_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGHV2-26: view

No data available for Suggested Antigen Peptide Sequences for IGHV2-26 Gene

Function for IGHV2-26 Gene

Molecular function for IGHV2-26 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV2-26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGHV2-26: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV2-26 Gene

Localization for IGHV2-26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV2-26 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV2-26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGHV2-26: view

No data available for Subcellular locations from COMPARTMENTS for IGHV2-26 Gene

Pathways & Interactions for IGHV2-26 Gene

SuperPathways for IGHV2-26 Gene

No Data Available

Interacting Proteins for IGHV2-26 Gene

Gene Ontology (GO) - Biological Process for IGHV2-26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IGHV2-26: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV2-26 Gene

Transcripts for IGHV2-26 Gene

mRNA/cDNA for IGHV2-26 Gene

(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV2-26 Gene

No ASD Table

Relevant External Links for IGHV2-26 Gene

GeneLoc Exon Structure for
IGHV2-26
ECgene alternative splicing isoforms for
IGHV2-26

Expression for IGHV2-26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGHV2-26 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV2-26 Gene

This gene is overexpressed in Spleen (x17.4), Colon - Transverse (x7.4), Minor Salivary Gland (x6.3), and Small Intestine - Terminal Ileum (x4.9).
genes like me logo Genes that share expression patterns with IGHV2-26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IGHV2-26 Gene

Orthologs for IGHV2-26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHV2-26 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ighv5-1 35
  • 40 (a)
ManyToMany
ighv5-5 35
  • 40 (a)
ManyToMany
ighv5-4 35
  • 39 (a)
ManyToMany
ighv5-7 35
  • 39 (a)
ManyToMany
ighv5-8 35
  • 39 (a)
ManyToMany
ighv5-2 35
  • 38 (a)
ManyToMany
ighv5-3 35
  • 38 (a)
ManyToMany
ighv8-2 35
  • 38 (a)
ManyToMany
ighv8-4 35
  • 37 (a)
ManyToMany
ighv8-3 35
  • 35 (a)
ManyToMany
ighv7-1 35
  • 33 (a)
ManyToMany
ighv8-1 35
  • 33 (a)
ManyToMany
Species where no ortholog for IGHV2-26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHV2-26 Gene

ENSEMBL:
Gene Tree for IGHV2-26 (if available)
TreeFam:
Gene Tree for IGHV2-26 (if available)

Paralogs for IGHV2-26 Gene

Pseudogenes.org Pseudogenes for IGHV2-26 Gene

genes like me logo Genes that share paralogs with IGHV2-26: view

Variants for IGHV2-26 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV2-26 Gene

HV226_HUMAN-A0A0B4J1V2
There are several alleles. The sequence shown is that of IMGT allele IGHV2-26*01.

Relevant External Links for IGHV2-26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV2-26

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV2-26 Gene

Disorders for IGHV2-26 Gene

No disorders were found for IGHV2-26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV2-26 Gene

Publications for IGHV2-26 Gene

  1. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  2. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  3. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64
  5. Nomenclature of the human immunoglobulin heavy (IGH) genes. (PMID: 11340299) Lefranc M.P. (Exp. Clin. Immunogenet. 2001) 4 64

Products for IGHV2-26 Gene

Sources for IGHV2-26 Gene

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