IGHV1OR21-1 Gene
protein-coding GIFtS: 19
GCID: GC21P010862
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immunoglobulin heavy variable 1/OR21-1 (non-functional)(Previous name: immunoglobulin heavy variable 1/OR21-1 pseudogene )
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Aliases
for IGHV1OR21-1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Immunoglobulin Heavy Variable 1/OR21-1 (Non-Functional)1 2 | | IGHV1/OR21-11 | | Immunoglobulin Heavy Variable 1/OR21-1 Pseudogene1 | | Immunoglobulin Heavy Variable 1 Orphon 21-13 |
Export aliases for IGHV1OR21-1 gene to outside databases |
Summaries
for IGHV1OR21-1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for IGHV1OR21-1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for IGHV1OR21-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IGHV1OR21-1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHV1OR21-1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21p11.2 Ensembl cytogenetic band: 21p11.2 HGNC cytogenetic band: 21p11.2IGHV1OR21-1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21P010862: view genomic region
(about GC identifiers)
Start:
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10,862,622 bp from pter |
End:
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10,863,067 bp from pter |
Size:
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446 bases |
Orientation:
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plus strand |
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Proteins
for IGHV1OR21-1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IV1U1_HUMAN, A6NJS3 (See
protein sequence)Recommended Name: Putative V-set and immunoglobulin domain-containing-like protein IGHV1OR21-1 precursor Size: 120 amino acids; 13370 Da
Subcellular location: Secreted (Potential)
Caution: Could be the product of a pseudogene. Encoded by an orphon, a gene putatively encoding part of animmunoglobulin chain but found outside of the immunoglobulin locus in the genomeExplore the universe of human proteins at neXtProt for IGHV1OR21-1: NX_A6NJS3
IGHV1OR21-1 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000303034 ENSP00000453358
Human Recombinant Protein Products for IGHV1OR21-1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005576 | extracellular region |
IEA | -- |
IGHV1OR21-1 for ontologies About GeneDecksing
IGHV1OR21-1 Antibody Products:
Assay Products for IGHV1OR21-1: |
Protein
Domains /
Families
for IGHV1OR21-1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IGHV1OR21-1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NJS3ProtoNet protein and cluster: A6NJS3 UniProtKB/Swiss-Prot: IV1U1_HUMAN, A6NJS3Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for IGHV1OR21-1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Animal Models:
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Pathways & Interactions
for IGHV1OR21-1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHV1OR21-1
|
Drugs & Compounds
for IGHV1OR21-1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IGHV1OR21-1
Search CenterWatch for drugs/clinical trials and news about IGHV1OR21-1 / IV1U1 
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Transcripts
for IGHV1OR21-1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000302092 ENST00000559480
GeneLoc Exon Structure
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Expression
for IGHV1OR21-1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IGHV1OR21-1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IGHV1OR21-1 Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for IGHV1OR21-1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat IGHV1OR21-1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGHV1OR21-1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHV1OR21-1 |
Orthologs
for IGHV1OR21-1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for IGHV1OR21-1 gene from 2/4 species (see all 4) About this table
ENSEMBL Gene Tree for IGHV1OR21-1 (if available)
TreeFam Gene Tree for IGHV1OR21-1 (if available) |
Paralogs
for IGHV1OR21-1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IGHV1OR21-1 gene
- IGHV1-22 IGHV5-512 IGHV1-182 IGHV1-452 IGHV7-812 IGHV1-692 IGHV1-582 IGHV1-82
- IGHV1-242 IGHV1-462 IGHV1-32
18/33 SIMAP similar genes for IGHV1OR21-1 using alignment to 1 protein entry: IV1U1_HUMAN(see all similar genes):IGHM scFv VH1 IgH IgG VH IGHV
VH3 VHC8 HEL180 IGVH VH HuVH8B VH
IGHV7-81 VH-3 family (VH26.)D/J VH87-2 VH-7 family (N54P3)D/J VH-3 family (VH26)D/J VHCH1
IGHV1OR21-1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for IGHV1OR21-1
PGOHUM00000247979 PGOHUM00000262047
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Genomic Variants
for IGHV1OR21-1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for IGHV1OR21-1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 IGHV1OR21-1 for disorders About MalaCards
IGHV1OR21-1 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: IGHV1OR21-1 (1 document)
Export disorders for IGHV1OR21-1 gene to outside databases
|
Publications
for IGHV1OR21-1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IGHV1OR21-1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGHV1OR21-1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
- The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. (PubMed id 1404388)1 Tomlinson I.M....Winter G. (1992)
- A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours. (PubMed id 3123998)1 Humphries C.G....Tucker P.W. (1988)
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External Searches for IGHV1OR21-1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing IGHV1OR21-1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing IGHV1OR21-1 gene
(According to HUGE)
About This Section
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Specialized Databases showing IGHV1OR21-1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for IGHV1OR21-1 gene:
Search GeneIP for patents involving IGHV1OR21-1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IGHV1OR21-1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGHV1OR21-1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHV1OR21-1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHV1OR21-1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGHV1OR21-1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHV1OR21-1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGHV1OR21-1 |
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 | | | | |  |  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHV1OR21-1 |
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