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Aliases for IGHV1-69-2 Gene

Aliases for IGHV1-69-2 Gene

  • Immunoglobulin Heavy Variable 1-69-2 2 3 5
  • Immunoglobulin Heavy Variable 1-F (Provisional) 2 3
  • IGHV1-F 3
  • IGHV1F 3

External Ids for IGHV1-69-2 Gene

Previous HGNC Symbols for IGHV1-69-2 Gene

  • IGHV1-F

Previous GeneCards Identifiers for IGHV1-69-2 Gene

  • GC14M106906
  • GC14M107545
  • GC14M107805
  • GC14M107898
  • GC14M107997

Summaries for IGHV1-69-2 Gene

GeneCards Summary for IGHV1-69-2 Gene

IGHV1-69-2 (Immunoglobulin Heavy Variable 1-69-2) is a Protein Coding gene. An important paralog of this gene is IGHV1-24.

UniProtKB/Swiss-Prot for IGHV1-69-2 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV1-69-2 Gene

Genomics for IGHV1-69-2 Gene

Regulatory Elements for IGHV1-69-2 Gene

Enhancers for IGHV1-69-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G106737 0.2 Ensembl 0.7 +0.0 47 0.2 IGHV1-69-2 IGHV3-69-1
GH14G106744 0.2 Ensembl 0.4 -7.9 -7854 1.2 IGHV1-69-2 ENSG00000283571
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGHV1-69-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHV1-69-2 Gene

Chromosome:
14
Start:
106,737,110 bp from pter
End:
106,737,547 bp from pter
Size:
438 bases
Orientation:
Minus strand

Genomic View for IGHV1-69-2 Gene

Genes around IGHV1-69-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV1-69-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV1-69-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV1-69-2 Gene

Proteins for IGHV1-69-2 Gene

  • Protein details for IGHV1-69-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0G2JMI3-HV692_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 1-69-2
    Protein Accession:
    A0A0G2JMI3

    Protein attributes for IGHV1-69-2 Gene

    Size:
    117 amino acids
    Molecular mass:
    12871 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGHV1-69-2 Gene

Post-translational modifications for IGHV1-69-2 Gene

No Post-translational modifications

Other Protein References for IGHV1-69-2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV1-69-2 Gene

Domains & Families for IGHV1-69-2 Gene

Gene Families for IGHV1-69-2 Gene

Protein Domains for IGHV1-69-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV1-69-2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV1-69-2 Gene

Function for IGHV1-69-2 Gene

Molecular function for IGHV1-69-2 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV1-69-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGHV1-69-2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV1-69-2 Gene

Localization for IGHV1-69-2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV1-69-2 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV1-69-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0072562 blood microparticle IBA --
genes like me logo Genes that share ontologies with IGHV1-69-2: view

No data available for Subcellular locations from COMPARTMENTS for IGHV1-69-2 Gene

Pathways & Interactions for IGHV1-69-2 Gene

SuperPathways for IGHV1-69-2 Gene

No Data Available

Interacting Proteins for IGHV1-69-2 Gene

Gene Ontology (GO) - Biological Process for IGHV1-69-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006958 complement activation, classical pathway IBA --
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with IGHV1-69-2: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV1-69-2 Gene

Drugs & Compounds for IGHV1-69-2 Gene

No Compound Related Data Available

Transcripts for IGHV1-69-2 Gene

mRNA/cDNA for IGHV1-69-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV1-69-2 Gene

No ASD Table

Relevant External Links for IGHV1-69-2 Gene

GeneLoc Exon Structure for
IGHV1-69-2
ECgene alternative splicing isoforms for
IGHV1-69-2

Expression for IGHV1-69-2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV1-69-2 Gene

Orthologs for IGHV1-69-2 Gene

Evolution for IGHV1-69-2 Gene

ENSEMBL:
Gene Tree for IGHV1-69-2 (if available)
TreeFam:
Gene Tree for IGHV1-69-2 (if available)

No data available for Orthologs for IGHV1-69-2 Gene

Paralogs for IGHV1-69-2 Gene

Variants for IGHV1-69-2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV1-69-2 Gene

HV692_HUMAN-A0A0G2JMI3
There are several alleles. The sequence shown is that of IMGT allele IGHV1-69-2*01.

Relevant External Links for IGHV1-69-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV1-69-2

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV1-69-2 Gene

Disorders for IGHV1-69-2 Gene

No disorders were found for IGHV1-69-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV1-69-2 Gene

Publications for IGHV1-69-2 Gene

  1. Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation. (PMID: 23541343) Watson C.T. … Breden F. (Am. J. Hum. Genet. 2013) 2 3 64
  2. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64

Products for IGHV1-69-2 Gene

Sources for IGHV1-69-2 Gene

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