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Aliases for IGHV1-69 Gene

Aliases for IGHV1-69 Gene

  • Immunoglobulin Heavy Variable 1-69 2 3
  • Immunoglobulin Heavy Variable 1-E 3
  • IGHV169 3
  • IGHV1-E 3
  • IGHV1E 3

External Ids for IGHV1-69 Gene

Previous HGNC Symbols for IGHV1-69 Gene

  • IGHV1-E

Previous GeneCards Identifiers for IGHV1-69 Gene

  • GC14U990216
  • GC14M105141
  • GC14M106240
  • GC14M107169
  • GC14M087323

Summaries for IGHV1-69 Gene

GeneCards Summary for IGHV1-69 Gene

IGHV1-69 (Immunoglobulin Heavy Variable 1-69) is a Protein Coding gene. An important paralog of this gene is IGHV1-24.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV1-69 Gene

Genomics for IGHV1-69 Gene

Genomic Location for IGHV1-69 Gene

106,714,682 bp from pter
106,715,181 bp from pter
500 bases
Minus strand

Genomic View for IGHV1-69 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGHV1-69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV1-69 Gene

No data available for Regulatory Elements for IGHV1-69 Gene

Proteins for IGHV1-69 Gene

  • Protein details for IGHV1-69 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein IGHV1-69
    Protein Accession:
    Secondary Accessions:

    Protein attributes for IGHV1-69 Gene

    117 amino acids
    Molecular mass:
    12659 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGHV1-69 Gene

Proteomics data for IGHV1-69 Gene at MOPED

Post-translational modifications for IGHV1-69 Gene

No Post-translational modifications

Other Protein References for IGHV1-69 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV1-69 Gene

Domains for IGHV1-69 Gene

Gene Families for IGHV1-69 Gene

Protein Domains for IGHV1-69 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV1-69: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV1-69 Gene

Function for IGHV1-69 Gene

Gene Ontology (GO) - Molecular Function for IGHV1-69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGHV1-69: view

miRNA for IGHV1-69 Gene

miRTarBase miRNAs that target IGHV1-69

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGHV1-69 Gene

Localization for IGHV1-69 Gene

Subcellular locations from

Jensen Localization Image for IGHV1-69 Gene COMPARTMENTS Subcellular localization image for IGHV1-69 gene
Compartment Confidence
extracellular 3
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IGHV1-69 Gene

Pathways for IGHV1-69 Gene

SuperPathways for IGHV1-69 Gene

No Data Available

Interacting Proteins for IGHV1-69 Gene

Gene Ontology (GO) - Biological Process for IGHV1-69 Gene


No data available for Pathways by source for IGHV1-69 Gene

Transcripts for IGHV1-69 Gene

mRNA/cDNA for IGHV1-69 Gene

(673) Additional mRNA sequences :
(162) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGHV1-69 Gene

Immunoglobulin heavy variable 1-69:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV1-69 Gene

No ASD Table

Relevant External Links for IGHV1-69 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHV1-69 Gene

mRNA expression in normal human tissues for IGHV1-69 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV1-69 Gene

This gene is overexpressed in Spleen (8.6) and Colon - Transverse (4.1).

Protein differential expression in normal tissues for IGHV1-69 Gene

This gene is overexpressed in Urine (60.4) and Serum (8.6).

Integrated Proteomics: protein expression from for IGHV1-69 Gene

SOURCE GeneReport for Unigene cluster for IGHV1-69 Gene Hs.704366

genes like me logo Genes that share expressions with IGHV1-69: view

Expression partners for IGHV1-69 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHV1-69 Gene

Orthologs for IGHV1-69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHV1-69 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
(Gallus gallus)
Aves -- 36
  • 34 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
(Danio rerio)
Actinopterygii ighv9-1 36
  • 43 (a)
Species with no ortholog for IGHV1-69:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHV1-69 Gene

Gene Tree for IGHV1-69 (if available)
Gene Tree for IGHV1-69 (if available)

Paralogs for IGHV1-69 Gene

genes like me logo Genes that share paralogs with IGHV1-69: view

Variants for IGHV1-69 Gene

Relevant External Links for IGHV1-69 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGHV1-69 Gene

Disorders for IGHV1-69 Gene

(1) University of Copenhagen DISEASES for IGHV1-69 Gene

Relevant External Links for IGHV1-69

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IGHV1-69: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for IGHV1-69 Gene

Publications for IGHV1-69 Gene

  1. Characterization of two highly homologous autoantibody-related VH1 genes in humans. (PMID: 8469934) Yang P.M. … Chen P.P. (Scand. J. Immunol. 1993) 2 3
  2. Characterization of immunoglobulin heavy and light chain gene expression in chronic lymphocytic leukemia and related disorders. (PMID: 19220298) Nakahashi H. … Karasawa M. (Cancer Sci. 2009) 3 48
  3. IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope. (PMID: 23840319) Que X. … Witztum J.L. (PLoS ONE 2013) 3
  4. Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association study. (PMID: 21326860) Tsai F.J. … Wu J.Y. (PLoS ONE 2011) 48
  5. Myosin-reactive autoantibodies in rheumatic carditis and normal fetus. (PMID: 9614934) Wu X. … Young D.C. (Clin. Immunol. Immunopathol. 1998) 3

Products for IGHV1-69 Gene

Sources for IGHV1-69 Gene

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