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IGHV1-58 Gene(Protein Coding)

Immunoglobulin Heavy Variable 1-58

GCID:
GC14M108383
GIFtS:
14
Genes Participants
UDN Logo

Aliases for IGHV1-58 Gene

Aliases for IGHV1-58 Gene

  • Immunoglobulin Heavy Variable 1-58 2 3 5
  • Immunogloblin Heavy Chain Variable Region 3
  • IGHV158 3
  • VH 3

External Ids for IGHV1-58 Gene

Previous GeneCards Identifiers for IGHV1-58 Gene

  • GC14U990219
  • GC14M105050
  • GC14M106149
  • GC14M107079
  • GC14M107083
  • GC14M107091
  • GC14M107185
  • GC14M107335
  • GC14M107487
  • GC14M107679
  • GC14M106649
  • GC14M107227
  • GC14M107784
  • GC14M107877
  • GC14M107976
  • GC14M108098
  • GC14M108239

Summaries for IGHV1-58 Gene

GeneCards Summary for IGHV1-58 Gene

IGHV1-58 (Immunoglobulin Heavy Variable 1-58) is a Protein Coding gene. An important paralog of this gene is IGHV1-3.

UniProtKB/Swiss-Prot for IGHV1-58 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Additional gene information for IGHV1-58 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV1-58 Gene

Genomics for IGHV1-58 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IGHV1-58 Gene

Promoters and enhancers for IGHV1-58 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14I106622 Enhancer 0.4 ENCODE dbSUPER 550.8 +0.5 523 0.2 IGHV1-58 IGHV3-57 IGH
GH14I106626 Enhancer 1 Ensembl ENCODE dbSUPER 0.8 -4.4 -4420 0.7 ZFP69B CTCF MAZ ZNF654 ZNF10 TRIM22 ZNF143 ZNF444 RAD21 IGHV4-59 IGHV3-66 IGHV1-58 IGH
GH14I106618 Enhancer 0.6 dbSUPER 0.8 +3.5 3532 1.6 SMARCA5 CTCF ATF4 CEBPA TRIM22 ZNF143 CEBPG ZNF444 ZBTB7B ZNF592 IGHV3-57 IGHV3-66 IGHV2-70D IGHV1-58 IGH
GH14I106625 Enhancer 0.2 dbSUPER 0.8 -2.9 -2886 1 IGHV1-58 IGHV4-59 IGH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGHV1-58 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGHV1-58 Gene

Genomic Locations for IGHV1-58 Gene
chr14:106,622,357-106,622,855
(GRCh38/hg38)
Size:
499 bases
Orientation:
Minus strand
chr14:107,078,371-107,078,869
(GRCh37/hg19)

Genomic View for IGHV1-58 Gene

Genes around IGHV1-58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV1-58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV1-58 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IGHV1-58 Gene

Proteins for IGHV1-58 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IGHV1-58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0C4DH39-HV158_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 1-58
    Protein Accession:
    A0A0C4DH39

    Protein attributes for IGHV1-58 Gene

    Size:
    117 amino acids
    Molecular mass:
    13005 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGHV1-58 Gene

Post-translational modifications for IGHV1-58 Gene

No Post-translational modifications

Other Protein References for IGHV1-58 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV1-58 Gene

Domains & Families for IGHV1-58 Gene

Gene Families for IGHV1-58 Gene

HGNC:

Protein Domains for IGHV1-58 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV1-58: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV1-58 Gene

Function for IGHV1-58 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IGHV1-58 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV1-58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGHV1-58: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV1-58 Gene

Localization for IGHV1-58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV1-58 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV1-58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0042571 immunoglobulin complex, circulating IBA --
genes like me logo Genes that share ontologies with IGHV1-58: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGHV1-58 Gene

Pathways & Interactions for IGHV1-58 Gene

SuperPathways for IGHV1-58 Gene

PathCards logo More details on SuperPathways for IGHV1-58
No Data Available

Interacting Proteins for IGHV1-58 Gene

Gene Ontology (GO) - Biological Process for IGHV1-58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006958 complement activation, classical pathway IBA --
GO:0042742 defense response to bacterium IBA --
genes like me logo Genes that share ontologies with IGHV1-58: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV1-58 Gene

Drugs & Compounds for IGHV1-58 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IGHV1-58 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IGHV1-58 Gene

(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV1-58 Gene

No ASD Table

Relevant External Links for IGHV1-58 Gene

GeneLoc Exon Structure for
IGHV1-58
ECgene alternative splicing isoforms for
IGHV1-58

Expression for IGHV1-58 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGHV1-58 Gene

mRNA expression in normal human tissues for IGHV1-58 Gene
mRNA expression by GTEx for IGHV1-58 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV1-58 Gene

This gene is overexpressed in Spleen (x13.5), Minor Salivary Gland (x7.2), Colon - Transverse (x6.7), Small Intestine - Terminal Ileum (x5.9), and Whole Blood (x5.6).
genes like me logo Genes that share expression patterns with IGHV1-58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV1-58 Gene

Orthologs for IGHV1-58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHV1-58 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 33 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 30 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves -- 34
  • 35 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 48 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii ighv4-3 34
  • 41 (a)
 ManyToMany
Species where no ortholog for IGHV1-58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHV1-58 Gene

ENSEMBL:
Gene Tree for IGHV1-58 (if available)
TreeFam:
Gene Tree for IGHV1-58 (if available)

Paralogs for IGHV1-58 Gene

Variants for IGHV1-58 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV1-58 Gene

HV158_HUMAN-A0A0C4DH39
There are several alleles. The sequence shown is that of IMGT allele IGHV1-58*01.

Additional Variant Information for IGHV1-58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV1-58

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV1-58 Gene

Disorders for IGHV1-58 Gene

No disorders were found for IGHV1-58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV1-58 Gene

Publications for IGHV1-58 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 58
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 58
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4 58
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 58

Products for IGHV1-58 Gene

Sources for IGHV1-58 Gene

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