IGHV1-58 Gene protein-coding GIFtS : 17 GCID: GC14 M107679
Immunoglobulin Heavy Variable 1-58
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Aliasesfor IGHV1-58 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section GeneCards Plus Aliases Immunoglobulin Heavy Variable 1-58 1 2 IGHV1582 VH2
Export aliases for IGHV1-58 gene to outside databases Previous GC identifers: GC14U990219 GC14M105050 GC14M106149 GC14M107079 GC14M107083 GC14M107091 GC14M107185 GC14M107335 GC14M107487
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Summariesfor IGHV1-58 gene (According to Entrez Gene ,
GeneCards ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section GeneCards Plus GeneCards Summary for IGHV1-58 Gene: IGHV1-58 (immunoglobulin heavy variable 1-58) is a protein-coding gene. An important paralog of this gene is IGHV1-2 .
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Genomic Viewsfor IGHV1-58 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 75) ,
Regulatory elements and Epigenetics data according to
QIAGEN , and/or
SwitchGear Genomics )About This Section GeneCards Plus Regulatory elements: Search for regulatory transcription factor binding sites for IGHV1-58 Other transcription factors Search Chromatin IP Primers for IGHV1-58 Epigenetics: DNA Methylation CpG Assay Predesigned for Pyrosequencing in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33 IGHV1-58 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M107679: view genomic region
(about GC identifiers )
Start: 107,078,371 bp from pter End:
107,078,869 bp from pter
Size: 499 bases Orientation:
minus strand
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Proteinsfor IGHV1-58 gene
(According to
1 UniProtKB ,
HORDE ,
2 neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Antibodies by
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section GeneCards Plus UniProtKB: --Explore proteomics data for IGHV1-58 at MOPED See IGHV1-58 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB ENSEMBL proteins: ENSP00000375037 IGHV1-58 Human Recombinant
Protein Products: IGHV1-58 Antibody
Products: IGHV1-58 Assay Products:
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Domains /for IGHV1-58 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section GeneCards Plus HGNC Gene Families: IGH: Immunoglobulins / IGH locus
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Functionfor IGHV1-58 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
QIAGEN
and/or HOMER ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
SwitchGear Genomics ,
Gene Editing from DNA2.0 ,
Clones from OriGene ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
ESI BIO ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene .)
About This Section GeneCards Plus Gene Ontology (GO): 1 molecular function term : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
-- --
About GeneDecksing Animal Models: Inhib. RNA Browse OriGene RNAi Predesigned siRNA for gene silencing in human mouse rat
Cell Line GenScript Custom overexpressing Cell Line Services for IGHV1-58 Browse ESI BIO Cell Lines and PureStem Progenitors for IGHV1-58 In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHV1-58
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Localizationfor IGHV1-58 gene
(According to UniProtKB , COMPARTMENTS Subcellular localization database ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene .)
About This Section GeneCards Plus Subcellular locations from COMPARTMENTS : Compartment Confidence extracellular 3 cytosol 1 nucleus 1
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Pathways & Interactionsfor IGHV1-58 gene
(SuperPaths according to PathCards ,
Pathways according to
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
QIAGEN ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene) .
About This Section GeneCards Plus Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGHV1-58 Interactions: Search GeneGlobe Interaction Network for IGHV1-58
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Drugs & Compoundsfor IGHV1-58 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience ,
ApexBio ,
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB )
About This Section GeneCards Plus Browse compounds at ApexBio Browse Tocris compounds for IGHV1-58
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Transcriptsfor IGHV1-58 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
SwitchGear Genomics ,
OriGene ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene , and/or
QIAGEN
)About This Section GeneCards Plus 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000390628 Inhib. RNA Browse OriGene RNAi Predesigned siRNA for gene silencing in human mouse rat
6 AceView cDNA sequences :
AF062225 AF062279 AF062174 AF174037 AF021955 AY393679 GeneLoc Exon Structure
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Expression for IGHV1-58 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MaxQB ,
plus additional links to
SOURCE , and/or
BioGPS , and/or
UniProtKB ,QIAGEN ,
Primers from
OriGene , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section GeneCards Plus IGHV1-58 expression in normal human tissues
(normalized intensities) IGHV1-58 embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: -- About this image
IGHV1-58 expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells DatabaseIGHV1-58 Protein expression data from MOPED1 2 3 : About this image Custom PCR Arrays for IGHV1-58 Primer Browse OriGene qPCR Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat IGHV1-58 QuantiTect SYBR Green Assays in human mouse rat QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHV1-58
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Orthologsfor IGHV1-58 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section GeneCards Plus Orthologs for IGHV1-58 gene from Selected species (see all 5 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
oppossum Mammalia --
Uncharacterized protein
33(a)
many ↔ many
3(432834857-432835207)
chicken Aves --
Uncharacterized protein
35(a)
many ↔ many
27(422970-423344)
lizard Reptilia --
Uncharacterized protein
48(a)
1 → many
GL343491.1(38006-38582)
zebrafish Actinopterygii ighv4-36
immunoglobulin heavy variable 4-3
41(a)
many ↔ many
3(34192493-34192981) ENSDARG00000096394
ENSEMBL Gene Tree for IGHV1-58 (if available)TreeFam Gene Tree for IGHV1-58 (if available)
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Paralogsfor IGHV1-58 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section GeneCards Plus Paralogs for IGHV1-58 gene IGHV1-2 2 IGHV1OR15-9 2 IGHV1-18 2 IGHV5-51 2 IGHV1-45 2 IGHV1-69 2 IGHV7-81 2 IGHV1-8 2 IGHV1-24 2 IGHV1OR15-1 2 IGHV1-46 2 IGHV1OR21-1 2 IGHV1-3 2 About GeneDecksing
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Genomic Variantsfor IGHV1-58 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) , the Human Cytochrome P450 Allele
Nomenclature Database , and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN )
About This Section GeneCards Plus Site Specific Mutation Identification with PCR Assays
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Disorders
/ Diseasesfor IGHV1-58 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section GeneCards Plus
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Publicationsfor IGHV1-58 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section GeneCards Plus PubMed articles for IGHV1-58 gene integrated from 10 sources :(articles sorted by number of sources associating them with IGHV1-58) Utopia : connect your pdf to the dynamic
The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. (PubMed id 9841928) 1 (J. Exp. Med. 1998) Organization and evolution of variable region genes of the human immunoglobulin heavy chain. (PubMed id 3097326) 1 (J. Mol. Biol. 1986)
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External Searches for IGHV1-58 gene (in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section GeneCards Plus
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Genome Databases showing IGHV1-58 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section GeneCards Plus
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Other Databases showing IGHV1-58 gene
(According to HUGE )
About This Section GeneCards Plus --
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Specialized Databases showing IGHV1-58 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , UniProtKB/TrEMBL , and/or others, e.g. Wikipedia and GeneReviews , via UniProtKB/Swiss-Prot )About This Section GeneCards Plus
Name Description PharmGKB entry for IGHV1-58 Pharmacogenomics, SNPs, Pathways IMGT entry for IGHV1-58The international I mM unoG eneT ics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
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About This Section GeneCards Plus Patent Information for IGHV1-58 gene: IGHV1-58 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IGHV1-58 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 . Clones from OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , and ESI BIO , PCR Arrays from QIAGEN , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , Enzo Life Sciences , and/or
ApexBio , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section GeneCards Plus
Block miRNA regulation of human, mouse, rat IGHV1-58 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IGHV1-58 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human mouse rat Predesigned siRNA for gene silencing in human mouse rat QuantiFast Probe-based Assays in human mouse rat QuantiTect SYBR Green Assays in human mouse rat Custom PCR Arrays for IGHV1-58 Search Chromatin IP Primers for IGHV1-58 Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IGHV1-58 Search GeneGlobe Interaction Network for IGHV1-58 Search Regulatory tfbs for IGHV1-58
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHV1-58
Search ThermoFisher Antibodies for IGHV1-58
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHV1-58
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