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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHV1-58 Gene

protein-coding   GIFtS: 15
GCID: GC14M107487

Immunoglobulin Heavy Variable 1-58
  Search for IGHV1-58
at
MalaCards
 

Aliases
for IGHV1-58 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Immunoglobulin Heavy Variable 1-581 2
IGHV1582
VH2

External Ids:    HGNC: 55551   Entrez Gene: 284642   Ensembl: ENSG000002119687   

Export aliases for IGHV1-58 gene to outside databases

Previous GC identifers: GC14U990219 GC14M105050 GC14M106149 GC14M107079 GC14M107083 GC14M107091 GC14M107185 GC14M107335


Summaries
for IGHV1-58 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for IGHV1-58 Gene: 
IGHV1-58 (immunoglobulin heavy variable 1-58) is a protein-coding gene. An important paralog of this gene is IGHV1-2.


Genomic Views
for IGHV1-58 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHV1-58
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHV1-58


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHV1-58 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHV1-58 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M107487:  view genomic region     (about GC identifiers)

Start:
 107,078,371 bp from pter      End:
 107,078,869 bp from pter
Size:
 499 bases      Orientation:
 minus strand

Proteins
for IGHV1-58 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB: --
Explore proteomics data for IGHV1-58 at MOPED 

IGHV1-58 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGHV1-58 Protein Expression

ENSEMBL proteins: 
 ENSP00000375037  

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Protein Domains /
Families
for IGHV1-58 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
 HGNC Gene Families: 
IGH: Immunoglobulins / IGH locus

  --

Function
for IGHV1-58 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
IGHV1-58 for ontologies           About GeneDecksing


Animal Models:
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miRNA
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In Situ Assay
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Pathways & Interactions
for IGHV1-58 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHV1-58

Drugs & Compounds
for IGHV1-58 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for IGHV1-58

Search CenterWatch for drugs/clinical trials and news about IGHV1-58

Transcripts
for IGHV1-58 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390628
miRNA
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6 AceView cDNA sequences:

AF062225 AF062174 AF062279 AF174037 AF021955 AY393679 

GeneLoc Exon Structure


Expression
for IGHV1-58 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHV1-58 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGHV1-58 Expression
About this image


See IGHV1-58 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGHV1-58
Primer
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In Situ
Assay Products: 
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Orthologs
for IGHV1-58 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGHV1-58 gene from 3 species (see representative species )    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
oppossum
(Monodelphis domestica)		 Mammalia --
--
(see all 3)		 --
 34(a)
28(a)
(see all 3)		 possible ortholog
possible ortholog
(see all 3)		 3(432834857-432835207)
3(432640537-432641574)
lizard
(Anolis carolinensis)		 Reptilia IGHV5-516
 Uncharacterized protein
 48(a)
 1 → many
 GL343491.1(38006-38582)
zebrafish
(Danio rerio)		 Actinopterygii ighv1-46
ighv1-16
(see all 15)		 immunoglobulin heavy variable 1-1
(see all 15)		 45(a)
44(a)
(see all 15)		 many ↔ many
many ↔ many
(see all 15)		 3(34106950-34107372)
3(34144993-34145449)


ENSEMBL Gene Tree for IGHV1-58 (if available)
TreeFam Gene Tree for IGHV1-58 (if available)

Paralogs
for IGHV1-58 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGHV1-58 gene
IGHV1-22  IGHV1OR15-92  IGHV1-182  IGHV5-512  IGHV1-452  IGHV1-692  IGHV7-812  IGHV1-82  
IGHV1-242  IGHV1OR15-12  IGHV1-462  IGHV1OR21-12  IGHV1-32  

IGHV1-58 for paralogs           About GeneDecksing



Genomic Variants
for IGHV1-58 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHV1-58
DNA2.0 Custom Variant and Variant Library Synthesis for IGHV1-58

Disorders / Diseases
for IGHV1-58 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Publications
for IGHV1-58 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGHV1-58 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGHV1-58)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. (PubMed id 9841928)1 Matsuda F....Honjo T. (1998)
  2. Organization and evolution of variable region genes of the human immunoglobulin heavy chain. (PubMed id 3097326)1 Kodaira M....Honjo T. (1986)

External Searches for IGHV1-58 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGHV1-58 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28464 HGNC: 5555 AceView: IGHV1-58 Ensembl:ENSG00000211968 euGenes: HUgn28464
ECgene: IGHV1-58 H-InvDB: IGHV1-58

Other Databases showing IGHV1-58 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGHV1-58 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGHV1-58 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHV1-58 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGHV1-58 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGHV1-58 gene:
Search GeneIP for patents involving IGHV1-58

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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