Aliases for IGHV1-58 Gene
Aliases for IGHV1-58 Gene
External Ids for IGHV1-58 Gene
- HGNC: 5555
- Entrez Gene: 28464
- Ensembl: ENSG00000211968
- UniProtKB: A0A0C4DH39
Previous GeneCards Identifiers for IGHV1-58 Gene
- GC14U990219
- GC14M105050
- GC14M106149
- GC14M107079
- GC14M107083
- GC14M107091
- GC14M107185
- GC14M107335
- GC14M107487
- GC14M107679
- GC14M106649
- GC14M107227
- GC14M107784
- GC14M107877
- GC14M107976
- GC14M108098
- GC14M108239
Summaries for IGHV1-58 Gene
GeneCards Summary for IGHV1-58 Gene
IGHV1-58 (Immunoglobulin Heavy Variable 1-58) is a Protein Coding gene. An important paralog of this gene is IGHV1-3.
UniProtKB/Swiss-Prot for IGHV1-58 Gene
-
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
Additional gene information for IGHV1-58 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV1-58 Gene
Genomics for IGHV1-58 Gene
GeneHancer (GH) Regulatory Elements for IGHV1-58 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH14I106622 | Enhancer | 0.4 | ENCODE dbSUPER | 550.8 | +0.5 | 523 | 0.2 | IGHV1-58 IGHV3-57 IGH | ||
GH14I106626 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 0.8 | -4.4 | -4420 | 0.7 | ZFP69B CTCF MAZ ZNF654 ZNF10 TRIM22 ZNF143 ZNF444 RAD21 | IGHV4-59 IGHV3-66 IGHV1-58 IGH | |
GH14I106618 | Enhancer | 0.6 | dbSUPER | 0.8 | +3.5 | 3532 | 1.6 | SMARCA5 CTCF ATF4 CEBPA TRIM22 ZNF143 CEBPG ZNF444 ZBTB7B ZNF592 | IGHV3-57 IGHV3-66 IGHV2-70D IGHV1-58 IGH | |
GH14I106625 | Enhancer | 0.2 | dbSUPER | 0.8 | -2.9 | -2886 | 1 | IGHV1-58 IGHV4-59 IGH |
Regulatory Element Products
Genomic Locations for IGHV1-58 Gene
- chr14:106,622,357-106,622,855
- (GRCh38/hg38)
- Size:
- 499 bases
- Orientation:
- Minus strand
- chr14:107,078,371-107,078,869
- (GRCh37/hg19)
Genomic View for IGHV1-58 Gene
- Cytogenetic band:
-
- 14q32.33 by Ensembl
- 14q32.33 by Entrez Gene
- 14q32.33 by HGNC


RefSeq DNA sequence for IGHV1-58 Gene
Proteins for IGHV1-58 Gene
-
Protein details for IGHV1-58 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A0A0C4DH39-HV158_HUMAN
- Recommended name:
- Immunoglobulin heavy variable 1-58
- Protein Accession:
- A0A0C4DH39
Protein attributes for IGHV1-58 Gene
- Size:
- 117 amino acids
- Molecular mass:
- 13005 Da
- Quaternary structure:
-
- Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
Post-translational modifications for IGHV1-58 Gene
Other Protein References for IGHV1-58 Gene
- ENSEMBL proteins:
Protein Products
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No data available for DME Specific Peptides for IGHV1-58 Gene
Domains & Families for IGHV1-58 Gene
Gene Families for IGHV1-58 Gene
Protein Domains for IGHV1-58 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV1-58 Gene
Function for IGHV1-58 Gene
Molecular function for IGHV1-58 Gene
- UniProtKB/Swiss-Prot Function:
- V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003823 | antigen binding | IBA | -- |
GO:0034987 | immunoglobulin receptor binding | IBA | -- |
Animal Model Products
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-
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-
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGHV1-58
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV1-58 Gene
Localization for IGHV1-58 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGHV1-58 Gene
- Secreted. Cell membrane.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0009897 | external side of plasma membrane | IBA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0042571 | immunoglobulin complex, circulating | IBA | -- |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGHV1-58 Gene
Pathways & Interactions for IGHV1-58 Gene
Interacting Proteins for IGHV1-58 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0006910 | phagocytosis, recognition | IBA | -- |
GO:0006911 | phagocytosis, engulfment | IBA | -- |
GO:0006958 | complement activation, classical pathway | IBA | -- |
GO:0042742 | defense response to bacterium | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for IGHV1-58 Gene
Transcripts for IGHV1-58 Gene
mRNA/cDNA for IGHV1-58 Gene
- (6) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
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-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGHV1-58
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for IGHV1-58 Gene
mRNA differential expression in normal tissues according to GTEx for IGHV1-58 Gene
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV1-58 Gene
Orthologs for IGHV1-58 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
zebrafish (Danio rerio) |
Actinopterygii | ighv4-3 34 |
|
ManyToMany |
- Species where no ortholog for IGHV1-58 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IGHV1-58 Gene
Variants for IGHV1-58 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV1-58 Gene
- HV158_HUMAN-A0A0C4DH39
- There are several alleles. The sequence shown is that of IMGT allele IGHV1-58*01.
Additional Variant Information for IGHV1-58 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IGHV1-58
No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV1-58 Gene
Disorders for IGHV1-58 Gene
No disorders were found for IGHV1-58 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV1-58 Gene
Publications for IGHV1-58 Gene
- Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
- Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 58
- Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 58
- Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4 58
- The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 58
Products for IGHV1-58 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for IGHV1-58
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Sources for IGHV1-58 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
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- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew