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Aliases for IGHV1-46 Gene

Aliases for IGHV1-46 Gene

  • Immunoglobulin Heavy Variable 1-46 2 3 5
  • Ig Heavy Chain V-I Region DOT 4
  • Ig Heavy Chain V-I Region HG3 4
  • Ig Heavy Chain V-I Region Mot 4
  • IGHV146 3

External Ids for IGHV1-46 Gene

Previous GeneCards Identifiers for IGHV1-46 Gene

  • GC14U990220
  • GC14M104938
  • GC14M106038
  • GC14M106968
  • GC14M106970
  • GC14M106998
  • GC14M107472
  • GC14M107664
  • GC14M106569
  • GC14M107037
  • GC14M107767
  • GC14M107860

Summaries for IGHV1-46 Gene

GeneCards Summary for IGHV1-46 Gene

IGHV1-46 (Immunoglobulin Heavy Variable 1-46) is a Protein Coding gene. An important paralog of this gene is IGHV1-2.

UniProtKB/Swiss-Prot for IGHV1-46 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV1-46 Gene

Genomics for IGHV1-46 Gene

Regulatory Elements for IGHV1-46 Gene

Enhancers for IGHV1-46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F106510 1.1 Ensembl ENCODE 0.8 -0.1 -137 3.7 CTCF POLR2A EBF1 TBX21 IGHV4-39 IGHV3-53 IGHV1-69 IGHV1-46 IGHVII-46-1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGHV1-46 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHV1-46 Gene

Chromosome:
14
Start:
106,511,115 bp from pter
End:
106,511,856 bp from pter
Size:
742 bases
Orientation:
Minus strand

Genomic View for IGHV1-46 Gene

Genes around IGHV1-46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV1-46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV1-46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV1-46 Gene

Proteins for IGHV1-46 Gene

  • Protein details for IGHV1-46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01743-HV146_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 1-46
    Protein Accession:
    P01743
    Secondary Accessions:
    • A0A0B4J1V4
    • P06326
    • P80421

    Protein attributes for IGHV1-46 Gene

    Size:
    117 amino acids
    Molecular mass:
    12933 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

neXtProt entry for IGHV1-46 Gene

Post-translational modifications for IGHV1-46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGHV1-46 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV1-46 Gene

Domains & Families for IGHV1-46 Gene

Gene Families for IGHV1-46 Gene

Protein Domains for IGHV1-46 Gene

Graphical View of Domain Structure for InterPro Entry

P01743

UniProtKB/Swiss-Prot:

HV146_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGHV1-46: view

No data available for Suggested Antigen Peptide Sequences for IGHV1-46 Gene

Function for IGHV1-46 Gene

Molecular function for IGHV1-46 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV1-46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS --
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGHV1-46: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV1-46 Gene

Localization for IGHV1-46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV1-46 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV1-46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGHV1-46: view

No data available for Subcellular locations from COMPARTMENTS for IGHV1-46 Gene

Pathways & Interactions for IGHV1-46 Gene

SuperPathways for IGHV1-46 Gene

No Data Available

Interacting Proteins for IGHV1-46 Gene

Selected Interacting proteins: P01743-HV146_HUMAN for IGHV1-46 Gene via IID

Symbol External ID(s) Details
IGLV7-43

Gene Ontology (GO) - Biological Process for IGHV1-46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS --
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGHV1-46: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV1-46 Gene

Transcripts for IGHV1-46 Gene

mRNA/cDNA for IGHV1-46 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV1-46 Gene

No ASD Table

Relevant External Links for IGHV1-46 Gene

GeneLoc Exon Structure for
IGHV1-46
ECgene alternative splicing isoforms for
IGHV1-46

Expression for IGHV1-46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGHV1-46 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV1-46 Gene

This gene is overexpressed in Spleen (x9.3) and Colon - Transverse (x6.0).

Protein differential expression in normal tissues from HIPED for IGHV1-46 Gene

This gene is overexpressed in Urine (62.9) and Serum (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHV1-46 Gene



Protein tissue co-expression partners for IGHV1-46 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGHV1-46: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHV1-46 Gene

Orthologs for IGHV1-46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHV1-46 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 37 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ighv4-2 35
  • 39 (a)
ManyToMany
Species where no ortholog for IGHV1-46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHV1-46 Gene

ENSEMBL:
Gene Tree for IGHV1-46 (if available)
TreeFam:
Gene Tree for IGHV1-46 (if available)

Paralogs for IGHV1-46 Gene

Variants for IGHV1-46 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV1-46 Gene

HV146_HUMAN-P01743
There are several alleles. The sequence shown is that of IMGT allele IGHV1-46*01 and IMGT allele IGHV1-46*03.

Sequence variations from dbSNP and Humsavar for IGHV1-46 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_076712 --

Relevant External Links for IGHV1-46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV1-46

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV1-46 Gene

Disorders for IGHV1-46 Gene

No disorders were found for IGHV1-46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV1-46 Gene

Publications for IGHV1-46 Gene

  1. Shared VH1-46 gene usage by pemphigus vulgaris autoantibodies indicates common humoral immune responses among patients. (PMID: 24942562) Cho M.J. … Payne A.S. (Nat Commun 2014) 3 64
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64

Products for IGHV1-46 Gene

Sources for IGHV1-46 Gene

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