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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHM Gene

protein-coding   GIFtS: 47
GCID: GC14M106318

Immunoglobulin Heavy Constant Mu

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Heavy Constant Mu1 2
AGM12 5
MU2 5
VH2

External Ids:    HGNC: 55411   Entrez Gene: 35072   Ensembl: ENSG000002118997   OMIM: 1470205   UniProtKB: P018713   

Export aliases for IGHM gene to outside databases

Previous GC identifers: GC14U990041 GC14M104145 GC14M105248 GC14M105389 GC14M086450


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGHM Gene:
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical
heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is
linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal
variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an
individual C region gene, that determines the isotype of the antibody and provides effector or signaling
functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining
(J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream
of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu
heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see
IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression
of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype
switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of
the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM
forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).(supplied by OMIM, Aug
2010)

GeneCards Summary for IGHM Gene: 
IGHM (immunoglobulin heavy constant mu) is a protein-coding gene. Diseases associated with IGHM include central nervous system lymphoma, and rabies, and among its related super-pathways are Immune response Lectin induced complement pathway and Immune System. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.

UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871
Function: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved
in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as
in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the
majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B
by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in
soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively
as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts

Gene Wiki entry for IGHM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHM
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHM gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106318:  view genomic region     (about GC identifiers)

Start:
106,318,037 bp from pter      End:
106,322,323 bp from pter
Size:
4,287 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871 (See protein sequence)
Recommended Name: Ig mu chain C region  
Size: 452 amino acids; 49307 Da
Subunit: Immunoglobulin (Ig) molecules consist of two chains, one heavy chain (which can be alpha, delta, epsilon,
gamma or mu) and one light chain (which can be kappa or lambda) each consisting of a variable and a constant
region. An IgM molecule contains thus a mu heavy chain combined with either a kappa or a lambda light chains. It
is found almost exclusively as a homopentamer in the serum. Membrane-bound IgM molecules are non-covalently
associated with heterodimer of CD79A and CD79B
Subcellular location: Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of
membrane-bound IgM to secretion of IgM
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAA33071.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA34971.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for IGHM:
2AGJ (3D)    
Secondary accessions: P20769
Alternative splicing: 2 isoforms:  P01871-1   P01871-2   (Ref.8 (AAB59422) sequence is in conflict in positions: 437:S->N, 439:D->E, 448:A->T, 471:KVK->K)

Explore the universe of human proteins at neXtProt for IGHM: NX_P01871

Explore proteomics data for IGHM at MOPED 

IGHM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGHM Protein Expression

ENSEMBL proteins: 
 ENSP00000375001  
Reactome Protein details: P01871
Human Recombinant Protein Products for IGHM: 
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Novus Biologicals IGHM Proteins
Novus Biologicals IGHM Lysate
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005886plasma membrane TAS--
GO:0016020membrane NAS--
GO:0016021integral to membrane IEA--

IGHM for ontologies           About GeneDecksing



IGHM Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of IGHM
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Novus Biologicals IGHM Antibodies
Abcam antibodies for IGHM
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ThermoFisher Antibodies for IGHM
LSBio Antibodies in human, mouse, rat for IGHM 

Assay Products for IGHM: 
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Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGH: Immunoglobulins / IGH locus

4 InterPro protein domains:
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like_dom
 IPR003006 Ig/MHC_CS

Graphical View of Domain Structure for InterPro Entry P01871

ProtoNet protein and cluster: P01871

1 Blocks protein domain: IPB003597 Immunoglobulin C-type


IGHM for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IGHM_HUMAN, P01871
Function: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved
in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as
in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the
majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B
by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in
soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively
as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts

     Genatlas biochemistry entry for IGHM:
immunoglobulin,mu

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding IEA--
GO:0005515protein binding ----
     
IGHM for ontologies           About GeneDecksing


Phenotypes:
     15/16 MGI mutant phenotypes (inferred from 16 alleles(MGI details for Ighm) (see all 16):
 cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size 
 hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
 no phenotypic analysis  normal  renal/urinary system  respiratory system  skeleton 

IGHM for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for IGHM: Ighmtm1Fbb Ighmtm1Cgn Ighmtm1Msn Ighmtm1Che Ighmtm2.1Bgmn Ighmtm2Che
                                                     Ighmtm1Sls Ighmtm2.1Che

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IGHM 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGHM

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGHM 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGHM 

miRNA
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Inhib. RNA
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of IGHM

Clone
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Cell Line
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Search LifeMap BioReagents cell lines for IGHM
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHM


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IGHM About   (see all 8)                                                                                              See pathways by source

SuperPathContained pathways About
1Immune response Lectin induced complement pathway
Immune response Classic complement pathway0.53
Immune response Classical complement pathway0.52
2Immune System
Immune System0.56
Adaptive Immune System0.56
3Signal transduction IP3 signaling
Signal transduction IP3 signaling0.92
4Immune response NFAT in immune response
Immune response NFAT in immune response0.90
5Signaling by the B Cell Receptor (BCR)
Signaling by the B Cell Receptor (BCR)0.81

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

4 EMD Millipore Pathways for IGHM
    Immune response Classic complement pathway
Immune response BCR pathway
Signal transduction IP3 signaling
Immune response NFAT in immune response


4 GeneGo (Thomson Reuters) Pathways for IGHM
    Immune response Classical complement pathway
Immune response BCR pathway
Signal transduction IP3 signaling
Immune response NFAT in immune response

1 BioSystems Pathway for IGHM
    B Cell Receptor Signaling Pathway

4        Reactome Pathways for IGHM
    Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
Adaptive Immune System
Immune System
Signaling by the B Cell Receptor (BCR)



IGHM for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGHM

5/44 Interacting proteins for IGHM (P018712, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
InteractantInteraction Details
GeneCardExternal ID(s)
SMN1Q166372, 3MINT-8271212 I2D: score=1 
SMN2Q166372, 3MINT-8271212 I2D: score=1 
UBQLN4Q9NRR52, 3MINT-2860019 I2D: score=3 
GADD45AP245222, 3MINT-8255857 I2D: score=1 
GSK3BP498412, 3MINT-8257328 I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS--

IGHM for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHM

Search CenterWatch for drugs/clinical trials and news about IGHM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390559(uc021ser.1)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGHM
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
Browse OriGene RNAi
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGHM
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for IGHM
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGHM
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHM
Sirion Biotech Customized lentivirus for stable overexpression of IGHM 
                     Customized lentivirus expression plasmids for stable overexpression of IGHM 
Primer
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SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IGHM
  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGHM
  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHM

24/413 AceView cDNA sequences (see all 413):

CR620071 BQ214223 CR612308 BG397823 AW328101 CA447517 CR595172 CR612969 
CR602293 BQ707700 CA426335 BU617323 AF487336 CR593349 BU731322 BU616371 
CR601777 CR603657 CR620098 BX414017 CR611468 CR595694 BU616272 CR606782 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHM expression in normal human tissues (normalized intensities)      IGHM embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGHM Expression
About this image


IGHM expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/12 selected tissues (see all 12) fully expand
 
 Adipose (Muscoskeletal System)    fully expand to see all 2 entries
         Body Subcutaneous White Adipose
 
 Lymph (Hematopoietic System)    fully expand to see all 2 entries
         LYMPH NODE   
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Myoblasts Mandibular Arch Muscles
 
 Thymus (Hematopoietic System)
         Thymus   
 
 Bone (Muscoskeletal System)
         Bone Marrow

See IGHM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGHM
    SABiosciences Custom PCR Arrays for IGHM
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHM

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IGHM gene from 3/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ighm5 immunoglobulin heavy constant mu   --   12 (62.10 cM) 113418950 
lizard
(Anolis carolinensis)
Reptilia IGHM6
immunoglobulin heavy constant mu
31(a)
1 ↔ 1
GL343491.1(399288-479888)
zebrafish
(Danio rerio)
Actinopterygii ighz6
ighm6
immunoglobulin heavy constant mu
19(a)
16(a)
many ↔ many
many ↔ many
3(34079980-34083059)
3(34048543-34145441)


ENSEMBL Gene Tree for IGHM (if available)
TreeFam Gene Tree for IGHM (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGHM gene
IGHG22  IGHE2  IGHA12  IGHG32  IGHG42  IGHG12  IGHA22  
18/59 SIMAP similar genes for IGHM using alignment to 2 protein entries:     IGHM_HUMAN (see all proteins) (see all similar genes):
IGHV1OR21-1    IGHV7-81    HEL180    scFv    VH-3 family (VH26)D/J    IGHV
IgG VH    VH    VH1    DKFZp686E23209    HuVH8B VH    VH-3 family (VH26.)D/J
VHC8    VH-7 family (N54P3)D/J    IgH    IGH@    VH3    F5-20

IGHM for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871
Polymorphism: All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 215 have been observed in
human mu chains


2 SNPs in IGHM are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0039034
----see VAR_0039032 G S mis40--------
VAR_0039044
----see VAR_0039042 V G mis40--------

HapMap Linkage Disequilibrium report for IGHM (106318037 - 106322323 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for IGHM: --

Human Gene Mutation Database (HGMD): IGHM

Locus Specific Mutation Databases (LSDB): IGHM
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGHM
DNA2.0 Custom Variant and Variant Library Synthesis for IGHM

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 147020   
OMIM disorders: 601495  
UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871
  • Agammaglobulinemia 1, autosomal recessive (AGM1) [MIM:601495]: A primary immunodeficiency characterized
    by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of
    B-cell development. Affected individuals develop severe infections in the first years of life. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 20/46 diseases for IGHM (see all 46):    About MalaCards
    central nervous system lymphoma    rabies    mixed cryoglobulinemia    cold agglutinin disease
    mu chain disease    primary malignant lymphoma    agammaglobulinemia 1, autosomal recessive    agammaglobulinemia 1
    follicular lymphoma    waldenstrom macroglobulinemia    macroglobulinemia    agammaglobulinemia
    burkitt's lymphoma    cryoglobulinemia    malt lymphoma    b-cell chronic lymphocytic leukemia
    narcolepsy    mantle cell lymphoma    hairy cell leukemia    chronic lymphocytic leukemia


    IGHM for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/35 Novoseek inferred disease relationships for IGHM gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    somatic mutations 88.8 48 10828040 (3), 9753060 (2), 11908722 (2), 7650379 (2) (see all 37)
    leukemia lymphocytic chronic 76.5 12 10828040 (2), 16317103 (1), 15621758 (1), 2156935 (1) (see all 11)
    lymphocytic leukemia chronic b-cell 71.4 3 15325098 (1), 15820941 (1), 1282064 (1)
    agammaglobulinemia 63.5 1 17709424 (1)
    x-linked agammaglobulinemia 59.8 1 7486530 (1)
    lymphoma follicular 59.6 3 16365601 (1), 10052716 (1), 10583269 (1)
    lymphoma small lymphocytic 56.6 1 10504519 (1)
    leukaemia lymphocytic 54.7 3 1379132 (1), 10583268 (1), 17122648 (1)
    mixed cryoglobulinemia 54.5 1 1282064 (1)
    myeloma 53.1 10 11021746 (3), 10221505 (3), 10419900 (1), 1495989 (1) (see all 6)

    Genatlas disease: IGHM
    agammaglobulinemia,Bruton like

    Genetic Association Database (GAD): IGHM
    Human Genome Epidemiology (HuGE) Navigator: IGHM (1 document)

    Export disorders for IGHM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGHM gene, integrated from 9 sources (see all 178):
    (articles sorted by number of sources associating them with IGHM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete nucleotide sequence of the membrane form of the human IgM heavy chain. (PubMed id 2115996)1, 2, 3 Friedlander R.M.... Leder P. (1990)
    2. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4 Miyagawa H....Horiuchi T. (2008)
    3. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)
    4. The complete nucleotide sequence of a human immunoglobulin genomic C mu gene. (PubMed id 2505237)1, 2 Dorai H. and Gillies S.D. (1989)
    5. Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences. (PubMed id 6795593)1, 2 Rabbitts T.H.... Milstein C.P. (1981)
    6. Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas. (PubMed id 6777778)1, 2 Dolby T.W.... Croce C.M. (1980)
    7. The primary structure of the constant part of mu-chain-disease protein BOT. (PubMed id 6777162)1, 2 Mihaesco E....Hilschmann N. (1980)
    8. Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin. (PubMed id 4742735)1, 2 Putnam F.W.... Shimizu A. (1973)
    9. The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), II: the amino acid sequence of the H-chain (mu- type), subgroup H III. Architecture of the complete IgM-molecule. (PubMed id 4803843)1, 2 Watanabe S.... Hilschmann N. (1973)
    10. The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. (PubMed id 2117639)1, 9 Tsubata T. and Reth M. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3507 HGNC: 5541 AceView: IGHD_ Ensembl:ENSG00000211899 euGenes: HUgn3507
    ECgene: IGHM H-InvDB: IGHM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGHM Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGHM The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IGHMbasehttp://bioinf.uta.fi/IGHMbase/
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHM&species=Homo+sapiens

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGHM gene:
    Search GeneIP for patents involving IGHM

    GeneCards and IP:
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