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IGHM Gene

protein-coding   GIFtS: 48
GCID: GC14M106318

Immunoglobulin Heavy Constant Mu

  See IGHM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Heavy Constant Mu1 2
AGM12 5
MU2 5
VH2

External Ids:    HGNC: 55411   Entrez Gene: 35072   Ensembl: ENSG000002118997   OMIM: 1470205   UniProtKB: P018713   

Export aliases for IGHM gene to outside databases

Previous GC identifers: GC14U990041 GC14M104145 GC14M105248 GC14M105389 GC14M086450


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGHM Gene:
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical
heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is
linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal
variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an
individual C region gene, that determines the isotype of the antibody and provides effector or signaling
functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining
(J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream
of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu
heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see
IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression
of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype
switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of
the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM
forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).(supplied by OMIM, Aug
2010)

GeneCards Summary for IGHM Gene:
IGHM (immunoglobulin heavy constant mu) is a protein-coding gene. Diseases associated with IGHM include central nervous system lymphoma, and primary malignant lymphoma. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.

UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871
Function: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved
in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as
in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the
majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B
by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in
soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively
as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts

Gene Wiki entry for IGHM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IGHM
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IGHM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGHM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHM gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106318:  view genomic region     (about GC identifiers)

Start:
106,318,037 bp from pter      End:
106,322,323 bp from pter
Size:
4,287 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871 (See protein sequence)
Recommended Name: Ig mu chain C region  
Size: 452 amino acids; 49307 Da
Subunit: Immunoglobulin (Ig) molecules consist of two chains, one heavy chain (which can be alpha, delta, epsilon,
gamma or mu) and one light chain (which can be kappa or lambda) each consisting of a variable and a constant
region. An IgM molecule contains thus a mu heavy chain combined with either a kappa or a lambda light chains. It
is found almost exclusively as a homopentamer in the serum. Membrane-bound IgM molecules are non-covalently
associated with heterodimer of CD79A and CD79B
Sequence caution: Sequence=CAA33071.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA34971.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for IGHM:
2AGJ (3D)    
Secondary accessions: P20769
Alternative splicing: 2 isoforms:  P01871-1   P01871-2   (Ref.8 (AAB59422) sequence is in conflict in positions: 437:S->N, 439:D->E, 448:A->T, 471:KVK->K)

Explore the universe of human proteins at neXtProt for IGHM: NX_P01871

Explore proteomics data for IGHM at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn46, Asn209, Asn272, Asn279, Asn439

  • See IGHM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000375001  
    Reactome Protein details: P01871

    IGHM Human Recombinant Protein Products:

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    antibodies-online proteins for IGHM (2 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGH: Immunoglobulins / IGH locus

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01871

    ProtoNet protein and cluster: P01871

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type


    Find genes that share domains with IGHM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IGHM_HUMAN, P01871
    Function: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved
    in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as
    in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the
    majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B
    by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in
    soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively
    as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts

         Genatlas biochemistry entry for IGHM:
    immunoglobulin,mu

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003697contributes to single-stranded DNA binding IDA--
    GO:0003823antigen binding IEA--
    GO:0005515protein binding ----
    GO:0031210contributes to phosphatidylcholine binding IDA--
    GO:0034987contributes to immunoglobulin receptor binding IDA--
         
    Find genes that share ontologies with IGHM           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 16 alleles(MGI details for Ighm) (see all 16):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     no phenotypic analysis  normal  renal/urinary system  respiratory system  skeleton 

    Find genes that share phenotypes with IGHM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IGHM: Ighmtm1Fbb Ighmtm1Cgn Ighmtm1Msn Ighmtm1Che Ighmtm2.1Bgmn Ighmtm2Che
                                                         Ighmtm1Sls Ighmtm2.1Che

       genOway: Develop your customized and physiologically relevant rodent model for IGHM

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGHM_HUMAN, P01871: Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of
    membrane-bound IgM to secretion of IgM
    IGHM_HUMAN, P01871: Isoform 2: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA--
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19199708
    GO:0071756pentameric IgM immunoglobulin complex IDA--

    Find genes that share ontologies with IGHM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGHM About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Downstream Signaling Events Of B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.79
    2Complement Pathway
    Immune response Classic complement pathway0.56
    3Immune response NFAT in immune response
    Immune response NFAT in immune response0.55
    4Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
    Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.47
    5Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43


    Find genes that share SuperPaths with IGHM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 GeneGo (Thomson Reuters) Pathways for IGHM
        Immune response Classical complement pathway
    Immune response BCR pathway
    Signal transduction IP3 signaling
    Immune response NFAT in immune response

    1 BioSystems Pathway for IGHM
        B Cell Receptor Signaling Pathway

    1 Reactome Pathway for IGHM
        Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGHM
    Interactions:

        GeneGlobe Interaction Network for IGHM

    Selected Interacting proteins for IGHM (P018712, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271212 I2D: score=1 
    SMN2Q166372, 3MINT-8271212 I2D: score=1 
    UBQLN4Q9NRR52, 3MINT-2860019 I2D: score=3 
    GADD45AP245222, 3MINT-8255857 I2D: score=1 
    GSK3BP498412, 3MINT-8257328 I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002250adaptive immune response IDA--
    GO:0019731antibacterial humoral response IDA--
    GO:0045087innate immune response IDA--
    GO:0050829defense response to Gram-negative bacterium IDA--

    Find genes that share ontologies with IGHM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGHM



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390559(uc021ser.1)
    miRNA
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    Selected AceView cDNA sequences (see all 413):

    CR598316 AW002798 AI274463 CR619232 AI356998 CR598566 CR620071 AI453840 
    BQ072420 BQ009008 CR626477 T29779 BM454441 BU731251 AI672856 CR619868 
    AW403590 CR598462 BU617128 BU615732 AI719045 CA426198 CR622374 CR620098 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGHM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGHM Expression
    About this image


    IGHM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    IGHM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGHM Protein Expression
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGHM gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ighm5 immunoglobulin heavy constant mu   --   12 (62.10 cM) 113418950 
    lizard
    (Anolis carolinensis)
    Reptilia IGHM6
    immunoglobulin heavy constant mu
    30(a)
    1 ↔ 1
    GL343491.1(399288-479888)
    zebrafish
    (Danio rerio)
    Actinopterygii ighv1-46
    immunoglobulin heavy variable 1-4
    17(a)
    1 → many
    3(34048543-34145418) ENSDARG00000096355


    ENSEMBL Gene Tree for IGHM (if available)
    TreeFam Gene Tree for IGHM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGHM gene
    IGHG22  IGHE2  IGHA12  IGHG32  IGHG42  IGHG12  IGHA22  
    Selected SIMAP similar genes for IGHM using alignment to 2 protein entries:     IGHM_HUMAN (see all proteins) (see all similar genes):
    IGHV1OR21-1    IGHV7-81    HEL180    scFv    VH-3 family (VH26)D/J    IGHV
    IgG VH    VH    VH1    DKFZp686E23209    HuVH8B VH    VH-3 family (VH26.)D/J
    VHC8    VH-7 family (N54P3)D/J    IgH    IGH@    VH3    F5-20

    Find genes that share paralogs with IGHM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    IGHM_HUMAN, P01871: All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 215 have been observed in
    human mu chains


    2 SNPs for IGHM    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0039034
    ----see VAR_0039032 G S mis40--------
    rs123651,2,4
    ----see VAR_0039042 mis40--------

    HapMap Linkage Disequilibrium report for IGHM (106318037 - 106322323 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IGHM: --
    Human Gene Mutation Database (HGMD): IGHM
    Locus Specific Mutation Databases (LSDB): IGHM

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGHM
    DNA2.0 Custom Variant and Variant Library Synthesis for IGHM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147020   
    OMIM disorders: 601495  
    UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871
  • Agammaglobulinemia 1, autosomal recessive (AGM1) [MIM:601495]: A primary immunodeficiency characterized
    by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of
    B-cell development. Affected individuals develop severe infections in the first years of life. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • Selected diseases for IGHM (see all 21):    
    About MalaCards
    central nervous system lymphoma    primary malignant lymphoma    rabies    agammaglobulinemia 1, autosomal recessive
    cold agglutinin disease    agammaglobulinemia 1    premature ovarian failure 2b    burkitt's lymphoma
    waldenstrom macroglobulinemia    follicular lymphoma    macroglobulinemia    agammaglobulinemia
    cryoglobulinemia    malt lymphoma    agammaglobulinemia 3    hairy cell leukemia
    mantle cell lymphoma    chronic lymphocytic leukemia    b-cell chronic lymphocytic leukemia    narcolepsy


    Find genes that share disorders with IGHM           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IGHM gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    somatic mutations 88.8 48 10828040 (3), 9753060 (2), 11908722 (2), 7650379 (2) (see all 37)
    leukemia lymphocytic chronic 76.5 12 10828040 (2), 16317103 (1), 15621758 (1), 2156935 (1) (see all 11)
    lymphocytic leukemia chronic b-cell 71.4 3 15325098 (1), 15820941 (1), 1282064 (1)
    agammaglobulinemia 63.5 1 17709424 (1)
    x-linked agammaglobulinemia 59.8 1 7486530 (1)
    lymphoma follicular 59.6 3 16365601 (1), 10052716 (1), 10583269 (1)
    lymphoma small lymphocytic 56.6 1 10504519 (1)
    leukaemia lymphocytic 54.7 3 1379132 (1), 10583268 (1), 17122648 (1)
    mixed cryoglobulinemia 54.5 1 1282064 (1)
    myeloma 53.1 10 11021746 (3), 10221505 (3), 10419900 (1), 1495989 (1) (see all 6)

    Genatlas disease: IGHM
    agammaglobulinemia,Bruton like

    Genetic Association Database (GAD): IGHM
    Human Genome Epidemiology (HuGE) Navigator: IGHM (1 document)

    Export disorders for IGHM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGHM gene, integrated from 10 sources (see all 181):
    (articles sorted by number of sources associating them with IGHM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete nucleotide sequence of the membrane form of the human IgM heavy chain. (PubMed id 2115996)1, 2, 3 Friedlander R.M.... Leder P. (Nucleic Acids Res. 1990)
    2. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4 Miyagawa H....Horiuchi T. (Rheumatology (Oxford) 2008)
    3. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (Proteomics 2004)
    4. The complete nucleotide sequence of a human immunoglobulin genomic C mu gene. (PubMed id 2505237)1, 2 Dorai H. and Gillies S.D. (Nucleic Acids Res. 1989)
    5. Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences. (PubMed id 6795593)1, 2 Rabbitts T.H.... Milstein C.P. (Nucleic Acids Res. 1981)
    6. Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas. (PubMed id 6777778)1, 2 Dolby T.W.... Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1980)
    7. The primary structure of the constant part of mu-chain-disease protein BOT. (PubMed id 6777162)1, 2 Mihaesco E....Hilschmann N. (Eur. J. Biochem. 1980)
    8. Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin. (PubMed id 4742735)1, 2 Putnam F.W.... Shimizu A. (Science 1973)
    9. The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), II: the amino acid sequence of the H-chain (mu- type), subgroup H III. Architecture of the complete IgM-molecule. (PubMed id 4803843)1, 2 Watanabe S.... Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1973)
    10. The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. (PubMed id 2117639)1, 9 Tsubata T. and Reth M. (J. Exp. Med. 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3507 HGNC: 5541 AceView: IGHD_ Ensembl:ENSG00000211899 euGenes: HUgn3507
    ECgene: IGHM H-InvDB: IGHM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGHM Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGHM The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IGHMbasehttp://bioinf.uta.fi/IGHMbase/
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHM&species=Homo+sapiens

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGHM gene:
    Search GeneIP for patents involving IGHM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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