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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHM Gene

protein-coding   GIFtS: 44
GCID: GC14M106318

immunoglobulin heavy constant mu
 Explore 46 diseases affiliated with
IGHM via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGHM    

Aliases
for IGHM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Heavy Constant Mu1 2
AGM12 5
MU2 5
VH2

External Ids:    HGNC: 55411   Entrez Gene: 35072   Ensembl: ENSG000002118997   OMIM: 1470205   UniProtKB: P018713   

Export aliases for IGHM gene to outside databases

Previous GC identifers: GC14U990041 GC14M104145 GC14M105248 GC14M105389 GC14M086450


Summaries
for IGHM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IGHM:
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy
chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a
light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region
containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that
determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is
encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D)
genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus
on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B
cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody
response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a
process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can
be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig
isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al.,
2005).(supplied by OMIM, Aug 2010)

UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871
Function: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in
early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in
recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of
normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family
of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which
represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After
the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts

Gene Wiki entry for IGHM


Genomic Views
for IGHM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHM
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHM gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106318:  view genomic region     (about GC identifiers)

Start:
 106,318,037 bp from pter      End:
 106,322,323 bp from pter
Size:
 4,287 bases      Orientation:
 minus strand

Proteins
for IGHM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871 (See protein sequence)
Recommended Name: Ig mu chain C region  
Size: 452 amino acids; 49307 Da
Subunit: Immunoglobulin (Ig) molecules consist of two chains, one heavy chain (which can be alpha, delta, epsilon,
gamma or mu) and one light chain (which can be kappa or lambda) each consisting of a variable and a constant region.
An IgM molecule contains thus a mu heavy chain combined with either a kappa or a lambda light chains. It is found
almost exclusively as a homopentamer in the serum. Membrane-bound IgM molecules are non-covalently associated with
heterodimer of CD79A and CD79B
Subcellular location: Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of
membrane-bound IgM to secretion of IgM
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAA33071.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA34971.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for IGHM:
2AGJ (3D)    
Secondary accessions: P20769
Alternative splicing: 2 isoforms:  P01871-1   P01871-2   (Ref.8 (AAB59422) sequence is in conflict in positions: 437:S->N, 439:D->E, 448:A->T, 471:KVK->K)

Explore the universe of human proteins at neXtProt for IGHM: NX_P01871

IGHM Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000375001  
Reactome Protein details: P01871
Human Recombinant Protein Products: 
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OriGene Custom Protein Services for IGHM 
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Novus Biologicals IGHM Proteins
Novus Biologicals IGHM Lysate
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005886plasma membrane TAS--
GO:0016020membrane NAS--
GO:0016021integral to membrane IEA--


IGHM for ontologies           About GeneDecksing



IGHM Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of IGHM
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OriGene Custom Antibody Services for IGHM 
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Novus Biologicals IGHM Antibodies
Search for Antibodies for IGHM at Abcam  
Browse Antibodies at Uscn
ThermoFisher Antibodies for IGHM

Assay Products for IGHM: 
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GenScript Custom Assay Services for IGHM
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for IGHM gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGHM for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like_dom
 IPR013783 Ig-like_fold
 IPR003006 Ig/MHC_CS
 IPR003597 Ig_C1-set

Graphical View of Domain Structure for InterPro Entry P01871

ProtoNet protein and cluster: P01871

1 Blocks protein family: IPB003597 Immunoglobulin C-type


Function
for IGHM gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871
Function: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in
early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in
recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of
normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family
of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which
represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After
the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts

     Genatlas biochemistry entry for IGHM:
immunoglobulin,mu

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGHM
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGHM
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for IGHM

Clone
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Cell Line
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Search LifeMap BioReagents cell lines for IGHM

In Situ Assay
Products:   
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHM

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding IEA--


IGHM for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-outs for IGHM: Ighmtm1Fbb Ighmtm1Cgn Ighmtm1Msn Ighmtm1Che Ighmtm2.1Bgmn Ighmtm2Che
                                               Ighmtm1Sls Ighmtm2.1Che
     15/16 MGI mutant phenotypes (inferred from 16 alleles) (MGI details for Ighm) (see all 16):
 cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size 
 hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
 no phenotypic analysis  normal  renal/urinary system  respiratory system  skeleton 

IGHM for phenotypes           About GeneDecksing


Pathways & Interactions
for IGHM gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Assembly of Signalosomes at the Activated BCR
Assembly of Signalosomes at the Activated BCR1.00
Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)0.45
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.78
2Immune response_NFAT in immune response
Immune response_NFAT in immune response1.00
Immune response NFAT in immune response0.91
3Signal transduction_IP3 signaling
Signal transduction_IP3 signaling1.00
Signal transduction IP3 signaling0.92
4Immune response_Classical complement pathway
Immune response_Classical complement pathway1.00
Immune response Classic complement pathway0.98
5Immune System
Immune System1.00
Adaptive Immune System0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for IGHM
    Immune response Classic complement pathway
Immune response BCR pathway
Signal transduction IP3 signaling
Immune response NFAT in immune response


4 GeneGo (Thomson Reuters) Pathways for IGHM
    Immune response Classical complement pathway
Immune response BCR pathway
Signal transduction IP3 signaling
Immune response NFAT in immune response

1 BioSystems Pathway for IGHM 
    B Cell Receptor Signaling Pathway

5/6        Reactome Pathways for IGHM (see all 6)
    Assembly of Signalosomes at the Activated BCR
Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
Adaptive Immune System
Immune System



IGHM for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGHM

5/44 Interacting proteins for IGHM (P018712, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
InteractantInteraction Details
GeneCardExternal ID(s)
SMN1Q166372, 3MINT-8271212 I2D: score=1 
SMN2Q166372, 3MINT-8271212 I2D: score=1 
UBQLN4Q9NRR52, 3MINT-2860019 I2D: score=3 
GADD45AP245222, 3MINT-8255857 I2D: score=1 
GSK3BP498412, 3MINT-8257328 I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS--


IGHM for ontologies           About GeneDecksing



Drugs & Compounds
for IGHM gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHM
Search CenterWatch for drugs/clinical trials and news about IGHM 

Transcripts
for IGHM gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390559(uc021ser.1)

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGHM
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGHM
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
Browse OriGene 29mer shRNA kits
Browse OriGene siRNA
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGHM
Clone
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for IGHM
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGHM
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHM 
Primer
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SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IGHM
  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGHM
  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHM

24/413 AceView cDNA sequences (see all 413):

CR591095 CR603685 CR591904 BU731251 CR592950 CA428437 BQ016700 BU615787 
CR613460 CR625051 AI719045 CR595172 CA447517 BM454441 BE295500 BU734351 
CR598316 CR606531 CR619868 CR597050 CR607337 BQ214223 CR598566 CR595694 

GeneLoc Exon Structure


Expression
for IGHM gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

IGHM expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
AdiposeVisceral White AdiposeAdipose
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See IGHM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGHM
    SABiosciences Custom PCR Arrays for IGHM
Primer
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In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHM

Orthologs
for IGHM gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGHM gene from 3/5 species (see all 5)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Ighm5 immunoglobulin heavy constant mu   --   12 (62.10 cM) 113418950 
lizard
(Anolis carolinensis)		 Reptilia IGHM6
--
 --
 31(a)
19(a)
 1 ↔ 1
possible ortholog
 GL343491.1(472437-479888)
GL343491.1(485127-498368)
zebrafish
(Danio rerio)		 Actinopterygii ighd6
ighz6
 immunoglobulin heavy constant zeta
 6(a)
20(a)
 many ↔ many
many ↔ many
 3(34034542-34046885)
3(34079980-34083059)


ENSEMBL Gene Tree for IGHM (if available)
TreeFam Gene Tree for IGHM (if available) 

Paralogs
for IGHM gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGHM gene
IGHG22  IGHE2  IGHG32  IGHA12  IGHG42  IGHG12  IGHA22  
18/63 SIMAP similar genes for IGHM using alignment to 2 protein entries:     IGHM_HUMAN (see all proteins) (see all similar genes):
IGHV1OR21-1    IGHV7-81    HEL180    scFv    VH-3 family (VH26)D/J    IGHV
IgG VH    VH    VH1    DKFZp686E23209    HuVH8B VH    VH-3 family (VH26.)D/J
VHC8    VH-7 family (N54P3)D/J    IgH    IGH@    VH3    F5-20

IGHM for paralogs           About GeneDecksing



Genomic Variants
for IGHM gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871
Polymorphism: All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 215 have been observed in human
mu chains


Human Gene Mutation Database (HGMD): IGHM

Locus Specific Mutation Databases (LSDB): IGHM

SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHM
DNA2.0 Custom Variant and Variant Library Synthesis for IGHM

Disorders / Diseases
for IGHM gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGHM for disorders           About GeneDecksing

OMIM gene information: 147020   
OMIM disorders: 601495  
UniProtKB/Swiss-Prot: IGHM_HUMAN, P01871
  • Defects in IGHM are the cause of agammaglobulinemia type 1 (AGM1) [MIM:601495]. It is a primary
    • immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due
    to an early block of B-cell development. Affected individuals develop severe infections in the first years of life

    20/46 diseases for IGHM (see all 46):    About MalaCards
    central nervous system lymphoma    mu chain disease    diffuse large b-cell lymphoma    waldenstrom macroglobulinemia
    cold agglutinin disease    b-cell lymphomas    agammaglobulinemia    malt lymphoma
    non-hodgkin lymphoma    primary biliary cirrhosis    macroglobulinemia    lupus erythematosus
    burkitt's lymphoma    agammaglobulinemia 1    hairy cell leukemia    cryoglobulinemia
    mantle cell lymphoma    primary malignant lymphoma    systemic lupus erythematosus    lymphocytic leukemia

    10/35 Novoseek disease relationships for IGHM gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    somatic mutations 88.8 48 10828040 (3), 9753060 (2), 11908722 (2), 7650379 (2) (see all 37)
    leukemia lymphocytic chronic 76.5 12 10828040 (2), 16317103 (1), 15621758 (1), 2156935 (1) (see all 11)
    lymphocytic leukemia chronic b-cell 71.4 3 15325098 (1), 15820941 (1), 1282064 (1)
    agammaglobulinemia 63.5 1 17709424 (1)
    x-linked agammaglobulinemia 59.8 1 7486530 (1)
    lymphoma follicular 59.6 3 16365601 (1), 10052716 (1), 10583269 (1)
    lymphoma small lymphocytic 56.6 1 10504519 (1)
    leukaemia lymphocytic 54.7 3 1379132 (1), 10583268 (1), 17122648 (1)
    mixed cryoglobulinemia 54.5 1 1282064 (1)
    myeloma 53.1 10 11021746 (3), 10221505 (3), 10419900 (1), 1495989 (1) (see all 6)

    Genatlas disease: IGHM
    agammaglobulinemia,Bruton like

    Human Genome Epidemiology (HuGE) Navigator: IGHM (1 document)

    Export disorders for IGHM gene to outside databases

    Publications
    for IGHM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGHM gene, integrated from 9 sources (see all 178):
    (articles sorted by number of sources associating them with IGHM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete nucleotide sequence of the membrane form of the human IgM heavy chain. (PubMed id 2115996)1, 2, 3 Friedlander R.M.... Leder P. (1990)
    2. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)
    3. The complete nucleotide sequence of a human immunoglobulin genomic C mu gene. (PubMed id 2505237)1, 2 Dorai H. and Gillies S.D. (1989)
    4. Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences. (PubMed id 6795593)1, 2 Rabbitts T.H.... Milstein C.P. (1981)
    5. Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas. (PubMed id 6777778)1, 2 Dolby T.W.... Croce C.M. (1980)
    6. The primary structure of the constant part of mu-chain-disease protein BOT. (PubMed id 6777162)1, 2 Mihaesco E....Hilschmann N. (1980)
    7. Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin. (PubMed id 4742735)1, 2 Putnam F.W.... Shimizu A. (1973)
    8. The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), II: the amino acid sequence of the H-chain (mu- type), subgroup H III. Architecture of the complete IgM-molecule. (PubMed id 4803843)1, 2 Watanabe S.... Hilschmann N. (1973)
    9. The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. (PubMed id 2117639)1, 9 Tsubata T. and Reth M. (1990)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for IGHM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing IGHM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3507 HGNC: 5541 AceView: IGHD_ Ensembl:ENSG00000211899 euGenes: HUgn3507
    ECgene: IGHM H-InvDB: IGHM

    Other Databases showing IGHM gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IGHM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGHM Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGHM The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IGHMbasehttp://bioinf.uta.fi/IGHMbase/
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHM&species=Homo+sapiens

    Intellectual Property
    for IGHM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGHM gene:
    Search GeneIP for patents involving IGHM

    GeneCards and IP:
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