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Aliases for IGHJ1 Gene

Aliases for IGHJ1 Gene

  • Immunoglobulin Heavy Joining 1 2 3 5
  • JH1 3

External Ids for IGHJ1 Gene

Previous GeneCards Identifiers for IGHJ1 Gene

  • GC14U990238
  • GC14M104303
  • GC14M105408
  • GC14M105416
  • GC14M105443
  • GC14M105462
  • GC14M105472
  • GC14M105484
  • GC14M105494
  • GC14M105504
  • GC14M105510
  • GC14M105521
  • GC14M105532
  • GC14M105546
  • GC14M106364
  • GC14M106425
  • GC14M106476
  • GC14M106690
  • GC14M107372
  • GC14M107564
  • GC14M105878
  • GC14M105943
  • GC14M106018
  • GC14M106089
  • GC14M106211

Summaries for IGHJ1 Gene

GeneCards Summary for IGHJ1 Gene

IGHJ1 (Immunoglobulin Heavy Joining 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGHJ1 Gene

  • J region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHJ1 Gene

Genomics for IGHJ1 Gene

Genomic Location for IGHJ1 Gene

Chromosome:
14
Start:
105,865,405 bp from pter
End:
105,865,458 bp from pter
Size:
54 bases
Orientation:
Minus strand

Genomic View for IGHJ1 Gene

Genes around IGHJ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHJ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHJ1 Gene

No data available for Regulatory Elements for IGHJ1 Gene

Proteins for IGHJ1 Gene

  • Protein details for IGHJ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0C4DH62-HJ01_HUMAN
    Recommended name:
    Immunoglobulin heavy joining 1
    Protein Accession:
    A0A0C4DH62

    Protein attributes for IGHJ1 Gene

    Size:
    17 amino acids
    Molecular mass:
    1910 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGHJ1 Gene

Post-translational modifications for IGHJ1 Gene

No Post-translational modifications

Other Protein References for IGHJ1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHJ1 Gene

Domains & Families for IGHJ1 Gene

Gene Families for IGHJ1 Gene

Protein Domains for IGHJ1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHJ1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHJ1 Gene

Function for IGHJ1 Gene

Molecular function for IGHJ1 Gene

UniProtKB/Swiss-Prot Function:
J region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHJ1 Gene

Localization for IGHJ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHJ1 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGHJ1: view

No data available for Subcellular locations from COMPARTMENTS for IGHJ1 Gene

Pathways & Interactions for IGHJ1 Gene

SuperPathways for IGHJ1 Gene

No Data Available

Interacting Proteins for IGHJ1 Gene

Gene Ontology (GO) - Biological Process for IGHJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IGHJ1: view

No data available for Pathways by source and SIGNOR curated interactions for IGHJ1 Gene

Drugs & Compounds for IGHJ1 Gene

(1) Drugs for IGHJ1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IGHJ1: view

Transcripts for IGHJ1 Gene

mRNA/cDNA for IGHJ1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGHJ1 Gene

No ASD Table

Relevant External Links for IGHJ1 Gene

GeneLoc Exon Structure for
IGHJ1
ECgene alternative splicing isoforms for
IGHJ1

Expression for IGHJ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGHJ1 Gene

mRNA differential expression in normal tissues according to GTEx for IGHJ1 Gene

This gene is overexpressed in Spleen (x12.6) and Whole Blood (x6.6).

NURSA nuclear receptor signaling pathways regulating expression of IGHJ1 Gene:

IGHJ1
genes like me logo Genes that share expression patterns with IGHJ1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHJ1 Gene

Orthologs for IGHJ1 Gene

Evolution for IGHJ1 Gene

ENSEMBL:
Gene Tree for IGHJ1 (if available)
TreeFam:
Gene Tree for IGHJ1 (if available)

No data available for Orthologs for IGHJ1 Gene

Paralogs for IGHJ1 Gene

No data available for Paralogs for IGHJ1 Gene

Variants for IGHJ1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHJ1 Gene

HJ01_HUMAN-A0A0C4DH62
The sequence shown is that of IMGT allele IGHJ1*01.

Relevant External Links for IGHJ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHJ1

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHJ1 Gene

Disorders for IGHJ1 Gene

No disorders were found for IGHJ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHJ1 Gene

Publications for IGHJ1 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  4. Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations. (PMID: 19744331) Lee T.S. … Albitar M. (BMC Struct. Biol. 2009) 22 64
  5. Mechanisms of constitutive activation of Janus kinase 2-V617F revealed at the atomic level through molecular dynamics simulations. (PMID: 19195039) Lee T.S. … Albitar M. (Cancer 2009) 22 64

Products for IGHJ1 Gene

Sources for IGHJ1 Gene

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