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IGHJ@ Gene

gene cluster GIFtS: 13

GC14U990040

immunoglobulin heavy joining group
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IGHJ)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
IGHJ ^²

Descriptions
immunoglobulin heavy joining group ^²

External Ids
HGNC: 5531¹
Entrez Gene: 3506²

Search outside databases for aliases for IGHJ@ gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for IGHJ@:

Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of

2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds

so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together.

Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and

a C-terminal constant (C) region, encoded by a C region gene (e.g., IGHG1; MIM 147100), that

provides effector or signaling functions. The heavy chain V region is encoded by 3 types of genes:

V genes (see MIM 147070), joining (J) genes, and diversity (D) genes (see MIM 146910). Random

selection of just 1 gene of each type to assemble a V region accounts for the great diversity of V

regions among Ig molecules. The heavy chain locus on chromosome 14 contains approximately 40

functional V genes, followed by approximately 25 functional D genes and approximately 6 functional

J genes. Due to polymorphism, the numbers of functional V, J, and D genes differ among individuals

(Janeway et al., 2005).[supplied by OMIM]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Chromosome:14
Entrez Gene cytogenetic band: 14q32.32-q32.33 HGNC cytogenetic band: 14q32.32-q32.33

GeneLoc gene densities for chromosome 14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for IGHJ@:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for IGHJ@

Assays for IGHJ@:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Browse siRNA at Sigma-Aldrich

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

Browse Origene genome-wide validated SYBR primer pairs

Genatlas biochemistry entry for IGHJ@:

immunoglobulin,heavy chain joining region

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IGHJ@

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Browse siRNA at Sigma-Aldrich

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Browse Origene for untagged/tagged cDNA clones in CMV expression vector

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IGHJ@ expression in normal and diseased human tissues

Data from GNF BioGPS
About these images

About these images

CGAP SAGE TAG: --

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147010

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

3 PubMed articles for IGHJ@ gene:

Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia. (PubMed id 17169423)³ Lee C.E....Collins A.M. (2007)
The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus. (PubMed id 3138112)³ Buluwela L....Rabbitts T.H. (1988)
Real-Time t(14;18)(q32;q21) PCR assay combined with high-resolution capillary electrophoresis: a novel and rapid approach that allows accurate quantitation and size determination of bcl-2/JH fusion sequences. (PubMed id 11950920)¹ Sanchez-Vega B....Luthra R. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
IMGT entry for IGHJ@	The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Licensable Technologies for IGHJ@
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IGHJ@:

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IGHJ@-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Browse siRNAs at Sigma-Aldrich		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for IGHJ@

Search Tocris compounds for IGHJ@

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for IGHJ@

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IGHJ@ Gene

gene cluster GIFtS: 13

Aliases &
Descriptions
for IGHJ@

Summaries
for IGHJ@

Genomic Location
for IGHJ@

Proteins
for IGHJ@

Protein Domains/
Families
for IGHJ@

Gene Function
for IGHJ@

Pathways & Interactions
for IGHJ@

Drugs & Compounds
for IGHJ@

Transcripts
for IGHJ@

Expression
for IGHJ@

Orthologs
for IGHJ@

Paralogs
for IGHJ@

SNPs/Variants
for IGHJ@

Disorders & Mutations
for IGHJ@

Medical News
for IGHJ@

Publications
for IGHJ@

Search for IGHJ@

Genome Databases showing IGHJ@

Other Databases showing IGHJ@

Specialized Databases showing IGHJ@

Licensable Technologies
for IGHJ@

Services
for IGHJ@

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IGHJ@ Gene

gene cluster GIFtS: 13

Aliases & Descriptionsfor IGHJ@

Summariesfor IGHJ@

Genomic Locationfor IGHJ@

Proteinsfor IGHJ@

Protein Domains/Familiesfor IGHJ@

Gene Functionfor IGHJ@

Pathways & Interactionsfor IGHJ@

Drugs & Compoundsfor IGHJ@

Transcriptsfor IGHJ@

Expression for IGHJ@

Orthologsfor IGHJ@

Paralogsfor IGHJ@

SNPs/Variantsfor IGHJ@

Disorders & Mutationsfor IGHJ@

Medical Newsfor IGHJ@

Publicationsfor IGHJ@

Search for IGHJ@

Genome Databases showing IGHJ@

Other Databases showing IGHJ@

Specialized Databases showing IGHJ@

Licensable Technologiesfor IGHJ@

Servicesfor IGHJ@

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IGHJ@

Summaries
for IGHJ@

Genomic Location
for IGHJ@

Proteins
for IGHJ@

Protein Domains/
Families
for IGHJ@

Gene Function
for IGHJ@

Pathways & Interactions
for IGHJ@

Drugs & Compounds
for IGHJ@

Transcripts
for IGHJ@

Expression
for IGHJ@

Orthologs
for IGHJ@

Paralogs
for IGHJ@

SNPs/Variants
for IGHJ@

Disorders & Mutations
for IGHJ@

Medical News
for IGHJ@

Publications
for IGHJ@

Licensable Technologies
for IGHJ@

Services
for IGHJ@