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IGHG4 Gene

protein-coding   GIFtS: 38
GCID: GC14M106090

Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)1 2

External Ids:    HGNC: 55281   Entrez Gene: 35032   Ensembl: ENSG000002118927   OMIM: 1471305   UniProtKB: P018613   

Export aliases for IGHG4 gene to outside databases

Previous GC identifers: GC14U990038 GC14M100081 GC14M104064 GC14M104066 GC14M105161


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGHG4 Gene:
IGHG4 (immunoglobulin heavy constant gamma 4 (G4m marker)) is a protein-coding gene. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.

Gene Wiki entry for IGHG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IGHG4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IGHG4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGHG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHG4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106090:  view genomic region     (about GC identifiers)

Start:
106,090,687 bp from pter      End:
106,092,403 bp from pter
Size:
1,717 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IGHG4_HUMAN, P01861 (See protein sequence)
Recommended Name: Ig gamma-4 chain C region  
Size: 327 amino acids; 35941 Da
Sequence caution: Sequence=AAB59394.1; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for IGHG4:
1ADQ (3D)        1BBJ (3D)        2FL5 (3D)        4B53 (3D)        4C54 (3D)        4C55 (3D)    

Explore the universe of human proteins at neXtProt for IGHG4: NX_P01861

Explore proteomics data for IGHG4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn177

  • See IGHG4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000374985  
    Reactome Protein details: P01861

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGH: Immunoglobulins / IGH locus

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01861

    ProtoNet protein and cluster: P01861

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type


    Find genes that share domains with IGHG4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for IGHG4:
    immunoglobulin,gamma 4

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IGHG4           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGHG4_HUMAN, P01861: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion3
    plasma membrane2
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0016020membrane ----
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with IGHG4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGHG4 About    
    See pathways by source

    SuperPathContained pathways About
    1Creation of C4 and C2 activators
    Creation of C4 and C2 activators0.85
    Complement cascade0.68
    Initial triggering of complement0.85
    FCGR activation0.54
    Classical antibody-mediated complement activation0.82
    Role of phospholipids in phagocytosis0.53
    2Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    3Development IGF 1 receptor signaling
    Immune response IL 4 signaling pathway0.39


    Find genes that share SuperPaths with IGHG4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for IGHG4
        Immune response IL-4 signaling pathway

    5 Reactome Pathways for IGHG4
        Classical antibody-mediated complement activation
    Regulation of actin dynamics for phagocytic cup formation
    FCGR activation
    Role of phospholipids in phagocytosis
    Initial triggering of complement


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGHG4
    Interactions:

        Search GeneGlobe Interaction Network for IGHG4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IGHG4 (P018612, 3 ENSP000003749854) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGKCP018342, 3, ENSP000003747774MINT-25060 I2D: score=1 STRING: ENSP00000374777
    F8ENSP000003533934STRING: ENSP00000353393
    F3ENSP000003341454STRING: ENSP00000334145
    IGHV5-51ENSP000003750354STRING: ENSP00000375035
    IGHV6-1ENSP000003750024STRING: ENSP00000375002
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ----
    GO:0006956complement activation TAS--
    GO:0006958complement activation, classical pathway TAS--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with IGHG4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for IGHG4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390543
    miRNA
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    2 AceView cDNA sequences:

    AJ294733 L13487 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGHG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGHG4 Expression
    About this image

    IGHG4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGHG4 Protein Expression
        Custom PCR Arrays for IGHG4
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGHG4 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    1 → many
    GL343491.1(461752-525278)
    zebrafish
    (Danio rerio)
    Actinopterygii ighv1-46
    immunoglobulin heavy variable 1-4
    14(a)
    1 → many
    3(34048543-34145418) ENSDARG00000096355
            Species with no ortholog for IGHG4

    ENSEMBL Gene Tree for IGHG4 (if available)
    TreeFam Gene Tree for IGHG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGHG4 gene
    IGHG22  IGHE2  IGHA12  IGHM2  IGHG32  IGHG12  IGHA22  
    Selected SIMAP similar genes for IGHG4 using alignment to 1 protein entry:     IGHG4_HUMAN(see all similar genes):
    DKFZp686M24218    DKFZp686E23209    DKFZp686I04196    IGHG2    DKFZp686C15213    DKFZp686G11190
    DKFZp686H20196    DKFZp686I15196    DKFZp686N02209    DKFZp686O01196    DKFZp686P15220    IGHG1
    VHCH1    DKFZp686C11235    DKFZp686K03196    DKFZp686I15212    FLJ00385    IGHG3

    Find genes that share paralogs with IGHG4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGHG4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147130    OMIM disorders: --


    Find genes that share disorders with IGHG4           About GenesLikeMe

    Genatlas disease: IGHG4
    immunoglobulin,gamma 4 deficiency


    Export disorders for IGHG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGHG4 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with IGHG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence of a human immunoglobulin C gamma 4 gene. (PubMed id 6299662)1, 2 Ellison J.W.... Hood L.E. (DNA 1981)
    2. Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain. (PubMed id 4192699)1, 2 Pink J.R.L.... Milstein C. (Biochem. J. 1970)
    3. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
    4. A strategy for precise and large scale identification of core fucosylated glycoproteins. (PubMed id 19139490)2 Jia W.... Qian X.H. (Mol. Cell. Proteomics 2009)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Human and murine immunoglobulin expression vector cassettes. (PubMed id 11257305)1 McLean G.R....Green N.S. (Mol. Immunol. 2000)
    8. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. (PubMed id 6421489)1 Flanagan J.G.... Rabbitts T.H. (Cell 1984)
    9. Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin. (PubMed id 6407005)1 Hisajima H....Honjo T. (Proc. Natl. Acad. Sci. U.S.A. 1983)
    10. Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. (PubMed id 6804948)1 Ellison J.W. and Hood L.E. (Proc. Natl. Acad. Sci. U.S.A. 1982)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3503 HGNC: 5528 AceView: IGHG4 Ensembl:ENSG00000211892 euGenes: HUgn3503
    ECgene: IGHG4 H-InvDB: IGHG4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGHG4 Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGHG4 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHG4&species=Homo+sapiens

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGHG4 gene:
    Search GeneIP for patents involving IGHG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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