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Aliases for IGHG4 Gene

Aliases for IGHG4 Gene

  • Immunoglobulin Heavy Constant Gamma 4 (G4m Marker) 2 3 5

External Ids for IGHG4 Gene

Previous GeneCards Identifiers for IGHG4 Gene

  • GC14U990038
  • GC14M100081
  • GC14M104064
  • GC14M104066
  • GC14M105161
  • GC14M106090

Summaries for IGHG4 Gene

GeneCards Summary for IGHG4 Gene

IGHG4 (Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)) is a Protein Coding gene. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Immune System. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHE.

Gene Wiki entry for IGHG4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHG4 Gene

Genomics for IGHG4 Gene

Regulatory Elements for IGHG4 Gene

Enhancers for IGHG4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IGHG4 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHG4 Gene

105,624,341 bp from pter
105,626,066 bp from pter
1,726 bases
Minus strand

Genomic View for IGHG4 Gene

Genes around IGHG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG4 Gene

Proteins for IGHG4 Gene

  • Protein details for IGHG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ig gamma-4 chain C region
    Protein Accession:

    Protein attributes for IGHG4 Gene

    327 amino acids
    Molecular mass:
    35941 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB59394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHG4 Gene

neXtProt entry for IGHG4 Gene

Proteomics data for IGHG4 Gene at MOPED

Post-translational modifications for IGHG4 Gene

Other Protein References for IGHG4 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHG4 Gene

Domains & Families for IGHG4 Gene

Gene Families for IGHG4 Gene

Protein Domains for IGHG4 Gene

Suggested Antigen Peptide Sequences for IGHG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHG4: view

No data available for UniProtKB/Swiss-Prot for IGHG4 Gene

Function for IGHG4 Gene

Molecular function for IGHG4 Gene

GENATLAS Biochemistry:
immunoglobulin,gamma 4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHG4 Gene

Localization for IGHG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG4 Gene


Gene Ontology (GO) - Cellular Components for IGHG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
genes like me logo Genes that share ontologies with IGHG4: view

No data available for Subcellular locations from COMPARTMENTS for IGHG4 Gene

Pathways & Interactions for IGHG4 Gene

genes like me logo Genes that share pathways with IGHG4: view

Interacting Proteins for IGHG4 Gene

Selected Interacting proteins: P01861-IGHG4_HUMAN for IGHG4 Gene via MINT I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for IGHG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS --
GO:0006956 complement activation TAS --
GO:0045087 innate immune response IBA,TAS --
GO:0050871 positive regulation of B cell activation IBA --
genes like me logo Genes that share ontologies with IGHG4: view

No data available for SIGNOR curated interactions for IGHG4 Gene

Drugs & Compounds for IGHG4 Gene

No Compound Related Data Available

Transcripts for IGHG4 Gene

mRNA/cDNA for IGHG4 Gene

(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG4 Gene

No ASD Table

Relevant External Links for IGHG4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHG4 Gene

mRNA expression in normal human tissues for IGHG4 Gene

mRNA differential expression in normal tissues according to GTEx for IGHG4 Gene

This gene is overexpressed in Spleen (x29.3).

Protein differential expression in normal tissues from HIPED for IGHG4 Gene

This gene is overexpressed in Serum (14.5) and Vitreous humor (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHG4 Gene

genes like me logo Genes that share expression patterns with IGHG4: view

Protein tissue co-expression partners for IGHG4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHG4 Gene

Orthologs for IGHG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
(Mus musculus)
Mammalia Ighg1 36
  • 61 (a)
Ighg2b 36
  • 57 (a)
Ighg2c 36
  • 49 (a)
Ighg3 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
-- 36
  • 42 (a)
-- 36
  • 16 (a)
-- 36
  • 20 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
(Danio rerio)
Actinopterygii ighv1-4 36
  • 14 (a)
Species with no ortholog for IGHG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHG4 Gene

Gene Tree for IGHG4 (if available)
Gene Tree for IGHG4 (if available)

Paralogs for IGHG4 Gene

Paralogs for IGHG4 Gene

genes like me logo Genes that share paralogs with IGHG4: view

Variants for IGHG4 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for IGHG4 Gene

Disorders for IGHG4 Gene

Genatlas disease for IGHG4 Gene

immunoglobulin,gamma 4 deficiency

Relevant External Links for IGHG4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGHG4: view

No data available for MalaCards and UniProtKB/Swiss-Prot for IGHG4 Gene

Publications for IGHG4 Gene

  1. Nucleotide sequence of a human immunoglobulin C gamma 4 gene. (PMID: 6299662) Ellison J.W. … Hood L.E. (DNA 1981) 3 4 67
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 3

Products for IGHG4 Gene

Sources for IGHG4 Gene