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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHG4 Gene

protein-coding   GIFtS: 36
GCID: GC14M106090

immunoglobulin heavy constant gamma 4 (G4m marker)
  Search for IGHG4
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGHG4    

Aliases
for IGHG4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)1 2

External Ids:    HGNC: 55281   Entrez Gene: 35032   Ensembl: ENSG000002118927   OMIM: 1471305   UniProtKB: P018613   

Export aliases for IGHG4 gene to outside databases

Previous GC identifers: GC14U990038 GC14M100081 GC14M104064 GC14M104066 GC14M105161


Summaries
for IGHG4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for IGHG4


Genomic Views
for IGHG4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHG4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHG4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHG4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106090:  view genomic region     (about GC identifiers)

Start:
 106,090,687 bp from pter      End:
 106,092,403 bp from pter
Size:
 1,717 bases      Orientation:
 minus strand

Proteins
for IGHG4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IGHG4_HUMAN, P01861 (See protein sequence)
Recommended Name: Ig gamma-4 chain C region  
Size: 327 amino acids; 35941 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAB59394.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for IGHG4:
1ADQ (3D)        1BBJ (3D)        2FL5 (3D)        4B53 (3D)    

Explore the universe of human proteins at neXtProt for IGHG4: NX_P01861

IGHG4 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000374985  
Reactome Protein details: P01861
Human Recombinant Protein Products: 
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Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005624membrane fraction ----
GO:0016020membrane NAS--


IGHG4 for ontologies           About GeneDecksing



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Protein Domains /
Families
for IGHG4 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGHG4 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like_dom
 IPR003006 Ig/MHC_CS

Graphical View of Domain Structure for InterPro Entry P01861

ProtoNet protein and cluster: P01861

1 Blocks protein family: IPB003597 Immunoglobulin C-type


Function
for IGHG4 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:
     Genatlas biochemistry entry for IGHG4:
immunoglobulin,gamma 4

miRNA
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Inhib. RNA
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Gene Editing
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In Situ Assay
Products:   
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding IEA--


IGHG4 for ontologies           About GeneDecksing



Pathways & Interactions
for IGHG4 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Cleavage of Alpha-1-Microglobulin
Classical antibody-mediated complement activation0.74
Initial triggering of complement0.60
Creation of C4 and C2 activators0.70
Role of phospholipids in phagocytosis0.53
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts0.66
Complement cascade0.47
FCGR activation0.65
2Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation1.00
Fcgamma receptor (FCGR) dependent phagocytosis0.80
Role of myosins in phagosome formation0.80
3Immune response_IL-4 signaling pathway
Immune response_IL-4 signaling pathway1.00
Immune response IL-4 signaling pathway0.98
4Immune System
Immune System1.00
Innate Immune System0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for IGHG4
    Immune response IL-4 signaling pathway


1 GeneGo (Thomson Reuters) Pathway for IGHG4
    Immune response IL-4 signaling pathway

5/12        Reactome Pathways for IGHG4 (see all 12)
    Role of myosins in phagosome formation
FCGR activation
Fcgamma receptor (FCGR) dependent phagocytosis
Classical antibody-mediated complement activation
Regulation of actin dynamics for phagocytic cup formation



IGHG4 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHG4

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for IGHG4 (P018612, 3 ENSP000003749854) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
IGKCP018342, 3, ENSP000003747774MINT-25060 I2D: score=1 STRING: ENSP00000374777
F8ENSP000003533934STRING: ENSP00000353393
IGLC2ENSP000003748564STRING: ENSP00000374856
F3ENSP000003341454STRING: ENSP00000334145
IGHV5-51ENSP000003750354STRING: ENSP00000375035
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS--
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0045087innate immune response TAS--


IGHG4 for ontologies           About GeneDecksing



Drugs & Compounds
for IGHG4 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHG4
Search CenterWatch for drugs/clinical trials and news about IGHG4 

Transcripts
for IGHG4 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390543

miRNA
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Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
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Browse OriGene siRNA
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Clone
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Primer
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  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHG4

2 AceView cDNA sequences:

AJ294733 L13487 

GeneLoc Exon Structure


Expression
for IGHG4 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHG4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See IGHG4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGHG4
    SABiosciences Custom PCR Arrays for IGHG4
Primer
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In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHG4

Orthologs
for IGHG4 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGHG4 gene from 2/5 species (see all 5)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
lizard
(Anolis carolinensis)		 Reptilia --
--
 --
 25(a)
17(a)
 1 ↔ many
possible ortholog
 GL343491.1(517133-525212)
GL343491.1(485127-498368)
zebrafish
(Danio rerio)		 Actinopterygii ighd6
ighz6
 immunoglobulin heavy constant zeta
 5(a)
14(a)
 many ↔ many
many ↔ many
 3(34034542-34046885)
3(34079980-34083059)


ENSEMBL Gene Tree for IGHG4 (if available)
TreeFam Gene Tree for IGHG4 (if available) 

Paralogs
for IGHG4 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGHG4 gene
IGHG22  IGHE2  IGHG32  IGHM2  IGHA12  IGHG12  IGHA22  
18/33 SIMAP similar genes for IGHG4 using alignment to 1 protein entry:     IGHG4_HUMAN(see all similar genes):
DKFZp686M24218    DKFZp686E23209    DKFZp686I04196    IGHG2    DKFZp686C15213    DKFZp686G11190
DKFZp686H20196    DKFZp686I15196    DKFZp686N02209    DKFZp686O01196    DKFZp686P15220    IGHG1
VHCH1    DKFZp686C11235    DKFZp686K03196    DKFZp686I15212    FLJ00385    IGHG3

IGHG4 for paralogs           About GeneDecksing



Genomic Variants
for IGHG4 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHG4
DNA2.0 Custom Variant and Variant Library Synthesis for IGHG4

Disorders / Diseases
for IGHG4 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGHG4 for disorders           About MalaCards

IGHG4 for disorders           About GeneDecksing

OMIM gene information: 147130    OMIM disorders: --

Genatlas disease: IGHG4
immunoglobulin,gamma 4 deficiency


Export disorders for IGHG4 gene to outside databases

Publications
for IGHG4 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGHG4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGHG4)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Nucleotide sequence of a human immunoglobulin C gamma 4 gene. (PubMed id 6299662)1, 2 Ellison J.W.... Hood L.E. (1981)
  2. Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain. (PubMed id 4192699)1, 2 Pink J.R.L.... Milstein C. (1970)
  3. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
  4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Human and murine immunoglobulin expression vector cassettes. (PubMed id 11257305)1 McLean G.R....Green N.S. (2000)
  7. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. (PubMed id 6421489)1 Flanagan J.G.... Rabbitts T.H. (1984)
  8. Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin. (PubMed id 6407005)1 Hisajima H....Honjo T. (1983)
  9. Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. (PubMed id 6804948)1 Ellison J.W. and Hood L.E. (1982)
  10. The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes. (PubMed id 6327276)1 Ueda S.... Honjo T. (1982)

External Searches for IGHG4 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGHG4 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3503 HGNC: 5528 AceView: IGHG4 Ensembl:ENSG00000211892 euGenes: HUgn3503
ECgene: IGHG4 H-InvDB: IGHG4

Other Databases showing IGHG4 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGHG4 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGHG4 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHG4 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHG4&species=Homo+sapiens

Intellectual Property
for IGHG4 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGHG4 gene:
Search GeneIP for patents involving IGHG4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGHG4 gene

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About This Section

 
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