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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHG4 Gene

protein-coding   GIFtS: 36
GCID: GC14M106090

Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)

  Search for IGHG4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)1 2

External Ids:    HGNC: 55281   Entrez Gene: 35032   Ensembl: ENSG000002118927   OMIM: 1471305   UniProtKB: P018613   

Export aliases for IGHG4 gene to outside databases

Previous GC identifers: GC14U990038 GC14M100081 GC14M104064 GC14M104066 GC14M105161


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGHG4 Gene: 
IGHG4 (immunoglobulin heavy constant gamma 4 (G4m marker)) is a protein-coding gene. Among its related super-pathways are Classical antibody-mediated complement activation and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.

Gene Wiki entry for IGHG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHG4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHG4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHG4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106090:  view genomic region     (about GC identifiers)

Start:
106,090,687 bp from pter      End:
106,092,403 bp from pter
Size:
1,717 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IGHG4_HUMAN, P01861 (See protein sequence)
Recommended Name: Ig gamma-4 chain C region  
Size: 327 amino acids; 35941 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAB59394.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for IGHG4:
1ADQ (3D)        1BBJ (3D)        2FL5 (3D)        4B53 (3D)    

Explore the universe of human proteins at neXtProt for IGHG4: NX_P01861

Explore proteomics data for IGHG4 at MOPED 

IGHG4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGHG4 Protein Expression

ENSEMBL proteins: 
 ENSP00000374985  
Reactome Protein details: P01861
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0016020membrane NAS--

IGHG4 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGH: Immunoglobulins / IGH locus

4 InterPro protein domains:
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like_dom
 IPR003006 Ig/MHC_CS

Graphical View of Domain Structure for InterPro Entry P01861

ProtoNet protein and cluster: P01861

1 Blocks protein domain: IPB003597 Immunoglobulin C-type


IGHG4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for IGHG4:
immunoglobulin,gamma 4

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding IEA--
GO:0005515protein binding ----
     
IGHG4 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IGHG4 About                                                                                                See pathways by source

SuperPathContained pathways About
1Classical antibody-mediated complement activation
Classical antibody-mediated complement activation0.88
Complement cascade0.76
Creation of C4 and C2 activators0.88
FCGR activation0.70
Initial triggering of complement0.86
Role of phospholipids in phagocytosis0.65
2Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation0.80
Fcgamma receptor (FCGR) dependent phagocytosis0.80
3Immune System
Immune System0.56
Innate Immune System0.50
4Immune response Fc epsilon RI pathway
Immune response IL-4 signaling pathway0.38

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for IGHG4
    Immune response IL-4 signaling pathway


1 GeneGo (Thomson Reuters) Pathway for IGHG4
    Immune response IL-4 signaling pathway

5/10        Reactome Pathways for IGHG4 (see all 10)
    FCGR activation
Fcgamma receptor (FCGR) dependent phagocytosis
Classical antibody-mediated complement activation
Regulation of actin dynamics for phagocytic cup formation
Creation of C4 and C2 activators



IGHG4 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHG4

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for IGHG4 (P018612, 3 ENSP000003749854) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
IGKCP018342, 3, ENSP000003747774MINT-25060 I2D: score=1 STRING: ENSP00000374777
F8ENSP000003533934STRING: ENSP00000353393
IGLC2ENSP000003748564STRING: ENSP00000374856
F3ENSP000003341454STRING: ENSP00000334145
IGHV5-51ENSP000003750354STRING: ENSP00000375035
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS--
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
GO:0045087innate immune response TAS--

IGHG4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHG4

Search CenterWatch for drugs/clinical trials and news about IGHG4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390543
miRNA
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2 AceView cDNA sequences:

L13487 AJ294733 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHG4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGHG4 Expression
About this image


See IGHG4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGHG4
    SABiosciences Custom PCR Arrays for IGHG4
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHG4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IGHG4 gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
24(a)
1 → many
GL343491.1(461752-525278)
zebrafish
(Danio rerio)
Actinopterygii ighm6
ighz6
immunoglobulin heavy constant zeta
13(a)
13(a)
many ↔ many
many ↔ many
3(34048543-34145441)
3(34079980-34083059)
        Species with no ortholog for IGHG4

ENSEMBL Gene Tree for IGHG4 (if available)
TreeFam Gene Tree for IGHG4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGHG4 gene
IGHG22  IGHE2  IGHA12  IGHM2  IGHG32  IGHG12  IGHA22  
18/33 SIMAP similar genes for IGHG4 using alignment to 1 protein entry:     IGHG4_HUMAN(see all similar genes):
DKFZp686M24218    DKFZp686E23209    DKFZp686I04196    IGHG2    DKFZp686C15213    DKFZp686G11190
DKFZp686H20196    DKFZp686I15196    DKFZp686N02209    DKFZp686O01196    DKFZp686P15220    IGHG1
VHCH1    DKFZp686C11235    DKFZp686K03196    DKFZp686I15212    FLJ00385    IGHG3

IGHG4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGHG4 for disorders           About MalaCards
OMIM gene information: 147130    OMIM disorders: --


IGHG4 for disorders           About GeneDecksing

Genatlas disease: IGHG4
immunoglobulin,gamma 4 deficiency


Export disorders for IGHG4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGHG4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGHG4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Nucleotide sequence of a human immunoglobulin C gamma 4 gene. (PubMed id 6299662)1, 2 Ellison J.W.... Hood L.E. (1981)
  2. Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain. (PubMed id 4192699)1, 2 Pink J.R.L.... Milstein C. (1970)
  3. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
  4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Human and murine immunoglobulin expression vector cassettes. (PubMed id 11257305)1 McLean G.R....Green N.S. (2000)
  7. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. (PubMed id 6421489)1 Flanagan J.G.... Rabbitts T.H. (1984)
  8. Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin. (PubMed id 6407005)1 Hisajima H....Honjo T. (1983)
  9. Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. (PubMed id 6804948)1 Ellison J.W. and Hood L.E. (1982)
  10. The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes. (PubMed id 6327276)1 Ueda S.... Honjo T. (1982)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3503 HGNC: 5528 AceView: IGHG4 Ensembl:ENSG00000211892 euGenes: HUgn3503
ECgene: IGHG4 H-InvDB: IGHG4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGHG4 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHG4 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHG4&species=Homo+sapiens

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGHG4 gene:
Search GeneIP for patents involving IGHG4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for IGHG4
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGHG4
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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