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Aliases for IGHG4 Gene

Aliases for IGHG4 Gene

  • Immunoglobulin Heavy Constant Gamma 4 (G4m Marker) 2 3 5
  • Ig Gamma-4 Chain C Region 4

External Ids for IGHG4 Gene

Previous GeneCards Identifiers for IGHG4 Gene

  • GC14U990038
  • GC14M100081
  • GC14M104064
  • GC14M104066
  • GC14M105161
  • GC14M106090

Summaries for IGHG4 Gene

GeneCards Summary for IGHG4 Gene

IGHG4 (Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)) is a Protein Coding gene. Among its related pathways are Role of phospholipids in phagocytosis and Innate Immune System. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.

UniProtKB/Swiss-Prot for IGHG4 Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Wiki entry for IGHG4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHG4 Gene

Genomics for IGHG4 Gene

Regulatory Elements for IGHG4 Gene

Enhancers for IGHG4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G104728 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +892.7 892707 9.3 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A AKT1 ADSSL1 SIVA1 CEP170B IGHG4 C14orf180
GH14G104766 1.5 Ensembl ENCODE dbSUPER 4.9 +858.1 858058 3.3 HDGF FOXA2 AGO1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 ADSSL1 AKT1 IGHG4 ENSG00000258430 LOC102723342
GH14G105329 1.1 Ensembl ENCODE dbSUPER 6.2 +295.7 295693 1.3 RING1 ZFHX2 RFX1 EGR1 BMI1 NR2F2 EGR2 C14orf79 LINC00638 ENSG00000257270 IGHG4 BRF1 ENSG00000279495
GH14G105590 0.6 dbSUPER 5.2 +34.0 34009 2.2 NFIB ZSCAN4 CREB1 FOS ZBTB8A ZNF548 FOXA1 ENSG00000257270 IGHG4 PACS2 IGHA2 IGHE
GH14G105629 0.4 Ensembl 0.7 -3.2 -3235 0.2 REST IGHG4 MIR8071-2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGHG4 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHG4 Gene

Chromosome:
14
Start:
105,624,341 bp from pter
End:
105,626,066 bp from pter
Size:
1,726 bases
Orientation:
Minus strand

Genomic View for IGHG4 Gene

Genes around IGHG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG4 Gene

Proteins for IGHG4 Gene

  • Protein details for IGHG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01861-IGHG4_HUMAN
    Recommended name:
    Immunoglobulin heavy constant gamma 4
    Protein Accession:
    P01861

    Protein attributes for IGHG4 Gene

    Size:
    327 amino acids
    Molecular mass:
    35941 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    SequenceCaution:
    • Sequence=AAB59394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHG4 Gene

neXtProt entry for IGHG4 Gene

Post-translational modifications for IGHG4 Gene

  • Glycosylation at posLast=177177
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHG4 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHG4 Gene

Domains & Families for IGHG4 Gene

Gene Families for IGHG4 Gene

Protein Domains for IGHG4 Gene

Suggested Antigen Peptide Sequences for IGHG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHG4: view

No data available for UniProtKB/Swiss-Prot for IGHG4 Gene

Function for IGHG4 Gene

Molecular function for IGHG4 Gene

GENATLAS Biochemistry:
immunoglobulin,gamma 4
UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGHG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGHG4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHG4 Gene

Localization for IGHG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG4 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22664934
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with IGHG4: view

No data available for Subcellular locations from COMPARTMENTS for IGHG4 Gene

Pathways & Interactions for IGHG4 Gene

genes like me logo Genes that share pathways with IGHG4: view

Gene Ontology (GO) - Biological Process for IGHG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGHG4: view

No data available for SIGNOR curated interactions for IGHG4 Gene

Drugs & Compounds for IGHG4 Gene

No Compound Related Data Available

Transcripts for IGHG4 Gene

mRNA/cDNA for IGHG4 Gene

(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG4 Gene

No ASD Table

Relevant External Links for IGHG4 Gene

GeneLoc Exon Structure for
IGHG4
ECgene alternative splicing isoforms for
IGHG4

Expression for IGHG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGHG4 Gene

mRNA differential expression in normal tissues according to GTEx for IGHG4 Gene

This gene is overexpressed in Spleen (x29.3).

Protein differential expression in normal tissues from HIPED for IGHG4 Gene

This gene is overexpressed in Serum (14.5) and Vitreous humor (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHG4 Gene



Protein tissue co-expression partners for IGHG4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGHG4 Gene:

IGHG4
genes like me logo Genes that share expression patterns with IGHG4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHG4 Gene

Orthologs for IGHG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ighg1 35
  • 61 (a)
ManyToMany
Ighg3 35
  • 60 (a)
ManyToMany
Ighg2b 35
  • 57 (a)
ManyToMany
Ighg2c 35
  • 49 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 20 (a)
ManyToMany
-- 35
  • 16 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 25 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 35
  • 14 (a)
OneToMany
Species where no ortholog for IGHG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHG4 Gene

ENSEMBL:
Gene Tree for IGHG4 (if available)
TreeFam:
Gene Tree for IGHG4 (if available)

Paralogs for IGHG4 Gene

Variants for IGHG4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHG4 Gene

IGHG4_HUMAN-P01861
There are several alleles. The sequence shown is that of IMGT allele IGHG4*04.

Relevant External Links for IGHG4 Gene

Human Gene Mutation Database (HGMD)
IGHG4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHG4

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHG4 Gene

Disorders for IGHG4 Gene

Genatlas disease for IGHG4 Gene

immunoglobulin,gamma 4 deficiency

Relevant External Links for IGHG4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGHG4
genes like me logo Genes that share disorders with IGHG4: view

No data available for MalaCards and UniProtKB/Swiss-Prot for IGHG4 Gene

Publications for IGHG4 Gene

  1. Nucleotide sequence of a human immunoglobulin C gamma 4 gene. (PMID: 6299662) Ellison J.W. … Hood L.E. (DNA 1981) 3 4 64
  2. Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain. (PMID: 4192699) Pink J.R.L. … Milstein C. (Biochem. J. 1970) 3 4 64
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for IGHG4 Gene

Sources for IGHG4 Gene

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