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Aliases for IGHG4 Gene

Aliases for IGHG4 Gene

  • Immunoglobulin Heavy Constant Gamma 4 (G4m Marker) 2 3

External Ids for IGHG4 Gene

Previous GeneCards Identifiers for IGHG4 Gene

  • GC14U990038
  • GC14M100081
  • GC14M104064
  • GC14M104066
  • GC14M105161
  • GC14M106090

Summaries for IGHG4 Gene

GeneCards Summary for IGHG4 Gene

IGHG4 (Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)) is a Protein Coding gene. Among its related pathways are Creation of C4 and C2 activators and Fcgamma receptor (FCGR) dependent phagocytosis. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG3.

Gene Wiki entry for IGHG4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHG4 Gene

Genomics for IGHG4 Gene

Genomic Location for IGHG4 Gene

Start:
105,624,341 bp from pter
End:
105,626,066 bp from pter
Size:
1,726 bases
Orientation:
Minus strand

Genomic View for IGHG4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGHG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG4 Gene

No data available for Regulatory Elements for IGHG4 Gene

Proteins for IGHG4 Gene

  • Protein details for IGHG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01861-IGHG4_HUMAN
    Recommended name:
    Ig gamma-4 chain C region
    Protein Accession:
    P01861
    Secondary Accessions:

    Protein attributes for IGHG4 Gene

    Size:
    327 amino acids
    Molecular mass:
    35941 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB59394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHG4 Gene

neXtProt entry for IGHG4 Gene

Proteomics data for IGHG4 Gene at MOPED

Post-translational modifications for IGHG4 Gene

Other Protein References for IGHG4 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGHG4 Gene

Domains for IGHG4 Gene

Gene Families for IGHG4 Gene

HGNC:
  • IGH :Immunoglobulins / IGH locus

Protein Domains for IGHG4 Gene

Suggested Antigen Peptide Sequences for IGHG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHG4: view

No data available for UniProtKB/Swiss-Prot for IGHG4 Gene

Function for IGHG4 Gene

Molecular function for IGHG4 Gene

GENATLAS Biochemistry:
immunoglobulin,gamma 4

Gene Ontology (GO) - Molecular Function for IGHG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGHG4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IGHG4 Gene

Localization for IGHG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGHG4 Gene COMPARTMENTS Subcellular localization image for IGHG4 gene
Compartment Confidence
extracellular 5
mitochondrion 3
plasma membrane 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGHG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22664934
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGHG4: view

Pathways for IGHG4 Gene

genes like me logo Genes that share pathways with IGHG4: view

Interacting Proteins for IGHG4 Gene

Selected Interacting proteins: P01861-IGHG4_HUMAN for IGHG4 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for IGHG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with IGHG4: view

Transcripts for IGHG4 Gene

mRNA/cDNA for IGHG4 Gene

(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG4 Gene

No ASD Table

Relevant External Links for IGHG4 Gene

GeneLoc Exon Structure for
IGHG4
ECgene alternative splicing isoforms for
IGHG4

Expression for IGHG4 Gene

mRNA expression in normal human tissues for IGHG4 Gene

mRNA differential expression in normal tissues according to GTEx for IGHG4 Gene

This gene is overexpressed in Spleen (29.3).

Protein differential expression in normal tissues for IGHG4 Gene

This gene is overexpressed in Serum (14.5) and Vitreous humor (7.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGHG4 Gene

genes like me logo Genes that share expressions with IGHG4: view

Expression partners for IGHG4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHG4 Gene

Orthologs for IGHG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ighg1 36
  • 61 (a)
ManyToMany
Ighg2b 36
  • 57 (a)
ManyToMany
Ighg2c 36
  • 49 (a)
ManyToMany
Ighg3 36
  • 60 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 36
  • 14 (a)
OneToMany
Species with no ortholog for IGHG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHG4 Gene

ENSEMBL:
Gene Tree for IGHG4 (if available)
TreeFam:
Gene Tree for IGHG4 (if available)

Paralogs for IGHG4 Gene

Paralogs for IGHG4 Gene

genes like me logo Genes that share paralogs with IGHG4: view

Variants for IGHG4 Gene

Relevant External Links for IGHG4 Gene

HapMap Linkage Disequilibrium report
IGHG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGHG4 Gene

Disorders for IGHG4 Gene

Genatlas disease for IGHG4 Gene

immunoglobulin,gamma 4 deficiency
genes like me logo Genes that share disorders with IGHG4: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and External Links for IGHG4 Gene

Publications for IGHG4 Gene

  1. Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain. (PMID: 4192699) Pink J.R.L. … Milstein C. (Biochem. J. 1970) 3 4
  2. Nucleotide sequence of a human immunoglobulin C gamma 4 gene. (PMID: 6299662) Ellison J.W. … Hood L.E. (DNA 1981) 3 4
  3. Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns. (PMID: 6327276) Ueda S. … Honjo T. (EMBO J. 1982) 3
  4. Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin. (PMID: 6407005) Hisajima H. … Honjo T. (Proc. Natl. Acad. Sci. U.S.A. 1983) 3
  5. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. (PMID: 6421489) Flanagan J.G. … Rabbitts T.H. (Cell 1984) 3

Products for IGHG4 Gene

Sources for IGHG4 Gene

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