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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGHG3 Gene

protein-coding GIFtS: 44
GCID: GC14M106231

immunoglobulin heavy constant gamma 3 (G3m marker)

Explore 12 diseases affiliated with
IGHG3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Immunoglobulin Heavy Constant Gamma 3 (G3m Marker)¹ ²
IgG3²
HDC³
Heavy Chain Disease Protein³

External Ids:	HGNC: 5527¹	Entrez Gene: 3502²	Ensembl: ENSG00000211897⁷	OMIM: 147120⁵	UniProtKB: P01860³

Export aliases for IGHG3 gene to outside databases

Previous GC identifers: GC14M103270 GC14U900162 GC14M104203 GC14M104148 GC14M104151 GC14M105246 GC14M105303 GC14M105255 GC14M086364

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for IGHG3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for IGHG3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGHG3 promoter sequence

Search SABiosciences Chromatin IP Primers for IGHG3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHG3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33

IGHG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHG3 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M106231: view genomic region (about GC identifiers)

Start:	106,232,251 bp from pter	End:	106,237,742 bp from pter
Size:	5,492 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IGHG3_HUMAN, P01860 (See protein sequence)

Recommended Name: Ig gamma-3 chain C region

Size: 377 amino acids; 41287 Da

Subunit: Homodimer

Subcellular location: Secreted

Miscellaneous: The hinge region in gamma-3 chains is about four times as long as in other gamma chains and contains

three identical 15-residue segments preceded by a similar 17-residue segment (12-28)

Secondary accessions: A2NU35

Explore the universe of human proteins at neXtProt for IGHG3: NX_P01860

IGHG3 Protein expression data from MOPED and PaxDb: About this image

ENSEMBL proteins:

ENSP00000374993

Reactome Protein details: P01860
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	Uscn Proteins for IGHG3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0016020	membrane	NAS	--

IGHG3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGHG3 for domains About GeneDecksing

4 InterPro domains/families:

IPR013783 Ig-like_fold

IPR003597 Ig_C1-set

IPR007110 Ig-like_dom

IPR003006 Ig/MHC_CS

Graphical View of Domain Structure for InterPro Entry P01860

ProtoNet protein and cluster: P01860

1 Blocks protein family: IPB003597 Immunoglobulin C-type

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for IGHG3:

immunoglobulin,gamma 3 (Gm marker)

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003823	antigen binding	IEA	--

IGHG3 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cleavage of Alpha-1-Microglobulin

Classical antibody-mediated complement activation	0.74	Initial triggering of complement	0.60
Creation of C4 and C2 activators	0.70	Role of phospholipids in phagocytosis	0.53
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts	0.66	Complement cascade	0.47
FCGR activation	0.65

Regulation of actin dynamics for phagocytic cup formation

	Regulation of actin dynamics for phagocytic cup formation	1.00			Fcgamma receptor (FCGR) dependent phagocytosis	0.80
	Role of myosins in phagosome formation	0.80

Immune System

Immune System

1.00

Innate Immune System

0.46

Immune response CD16 signaling in NK cells

Immune response CD16 signaling in NK cells

1.00

Immune response_CD16 signaling in NK cells

0.99

IL4-mediated signaling events

IL4-mediated signaling events

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for IGHG3

Immune response CD16 signaling in NK cells

1 GeneGo (Thomson Reuters) Pathway for IGHG3

Immune response CD16 signaling in NK cells

1 BioSystems Pathway for IGHG3

IL4-mediated signaling events

5/12 Reactome Pathways for IGHG3 (see all 12)

	Role of myosins in phagosome formation
	FCGR activation
	Fcgamma receptor (FCGR) dependent phagocytosis
	Classical antibody-mediated complement activation
	Regulation of actin dynamics for phagocytic cup formation

IGHG3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IGHG3

1 Interacting protein for IGHG3 (P01860^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IKBKG	Q9Y6K9²^,³	MINT-48135 I2D: score=2

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	NAS	--
GO:0006956	complement activation	TAS	--
GO:0006958	complement activation, classical pathway	TAS	--
GO:0045087	innate immune response	TAS	--

IGHG3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHG3
Search CenterWatch for drugs/clinical trials and news about IGHG3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000390551(uc001ysh.1 uc001ysi.1)

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24/413 AceView cDNA sequences (see all 413):

BU736878 AI983792 CR597050 CR625295 T29779 CR602708 BQ015802 CR612378

CR611790 BU615960 CR608756 CR626477 AA321498 BU731251 CR602293 CR612813

AW403590 CR594000 CR612985 BU726459 BM987706 CR612254 AW328101 CR598316

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See IGHG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGHG3

SABiosciences Custom PCR Arrays for IGHG3

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IGHG3 gene from 2/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- --	--	26(a) 18(a)	1 ↔ many possible ortholog	GL343491.1(517133-525212) GL343491.1(485127-498368)
zebrafish (Danio rerio)	Actinopterygii	ighd⁶ ighz⁶	immunoglobulin heavy constant zeta	6(a) 14(a)	many ↔ many many ↔ many	3(34034542-34046885) 3(34079980-34083059)

ENSEMBL Gene Tree for IGHG3 (if available)
TreeFam Gene Tree for IGHG3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGHG3 gene

IGHG2² IGHE² IGHM² IGHA1² IGHG4² IGHG1² IGHA2²

18/21 SIMAP similar genes for IGHG3 using alignment to 1 protein entry: IGHG3_HUMAN(see all similar genes):

DKFZp686I15212 FLJ00385 VHCH1 DKFZp686E23209 DKFZp686G11190 DKFZp686H20196

DKFZp686I04196 DKFZp686I15196 DKFZp686N02209 DKFZp686O01196 DKFZp686P15220 IGH@

IGHG1 DKFZp686C11235 DKFZp686C15213 DKFZp686K03196 DKFZp686M24218 IGHG2

IGHG3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: IGHG3_HUMAN, P01860

Polymorphism: The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths. Variant WIS is

lacking most of the V region and all of the CH1 region. It has an extra interchain disulfide bond at position 7 in

addition to the 11 normally present in the hinge region. Variant ZUC lackS most of the V region, all of the CH1

region, and part of the hinge. Variant OMM may represent an allelic form or another gamma chain subclass

Human Gene Mutation Database (HGMD): IGHG3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGHG3 for disorders           About GeneDecksing

OMIM gene information: 147120    OMIM disorders: --

12 diseases for IGHG3:    About MalaCards

gamma heavy chain disease heavy chain disease relapsing-remitting multiple sclerosis congenital hypogammaglobulinemia

bullous pemphigoid multiple sclerosis ulcerative colitis hepatitis a

crohn's disease alzheimer's disease asthma hepatitis

Human Genome Epidemiology (HuGE) Navigator: IGHG3 (1 document)

Export disorders for IGHG3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGHG3 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with IGHG3)

Utopia: connect your pdf to the dynamic
world of online information

Gamma heavy chain disease in man: cDNA sequence supports partial gene deletion model. (PubMed id 6808505)^{1, 2, 3} Alexander A.... Buxbaum J.N. (1982)
Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes. (PubMed id 3081877)^{1, 2} Huck S.... Lefranc G. (1986)
Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis. (PubMed id 6774747)^{1, 2} Frangione B.... Franklin E.C. (1980)
Primary structure of the 'hinge' region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit. (PubMed id 402363)^{1, 2} Michaelsen T.E.... Franklin E.C. (1977)
The amino acid sequence of 'heavy chain disease' protein ZUC. Structure of the Fc fragment of immunoglobulin G3. (PubMed id 823945)^{1, 2} Wolfenstein-Todel C.... Franklin E.C. (1976)
Immunoglobulin GM genes as functional risk and protec tive factors for the development of Alzheimer's disease. (PubMed id 19542624)¹ Pandey J.P. (2009)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
Association between Gm allotypes and asthma severity from childhood to young middle age. (PubMed id 17933503)¹ Gustafsson P.M....Kjellman B. (2008)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)² Liu T.... Smith R.D. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3502	HGNC: 5527	AceView: IGHD_	Ensembl:ENSG00000211897	euGenes: HUgn3502
ECgene: IGHG3	H-InvDB: IGHG3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IGHG3	Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHG3	The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DB	http://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHG3&species=Homo+sapiens

Intellectual Property for IGHG3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IGHG3 gene:
Search GeneIP for patents involving IGHG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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IGHG3 Gene

immunoglobulin heavy constant gamma 3 (G3m marker)

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IGHG3 Gene

immunoglobulin heavy constant gamma 3 (G3m marker)

Aliasesfor IGHG3 gene

Summariesfor IGHG3 gene

Genomic Viewsfor IGHG3 gene

Proteinsfor IGHG3 gene

Protein Domains /Familiesfor IGHG3 gene

Functionfor IGHG3 gene

Pathways & Interactionsfor IGHG3 gene

Drugs & Compoundsfor IGHG3 gene

Transcriptsfor IGHG3 gene

Expression for IGHG3 gene

Orthologsfor IGHG3 gene

Paralogsfor IGHG3 gene

Genomic Variantsfor IGHG3 gene

Disorders / Diseasesfor IGHG3 gene

Publicationsfor IGHG3 gene

External Searches for IGHG3 gene

Genome Databases showing IGHG3 gene

Other Databases showing IGHG3 gene

Specialized Databases showing IGHG3 gene

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Productsfor IGHG3 gene

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Aliases
for IGHG3 gene

Summaries
for IGHG3 gene

Genomic Views
for IGHG3 gene

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for IGHG3 gene

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Families
for IGHG3 gene

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for IGHG3 gene

Pathways & Interactions
for IGHG3 gene

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for IGHG3 gene

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for IGHG3 gene

Expression
for IGHG3 gene

Orthologs
for IGHG3 gene

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for IGHG3 gene

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for IGHG3 gene

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for IGHG3 gene

Publications
for IGHG3 gene

Intellectual Property
for IGHG3 gene

Products
for IGHG3 gene