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Aliases for IGHG3 Gene

Aliases for IGHG3 Gene

  • Immunoglobulin Heavy Constant Gamma 3 (G3m Marker) 2 3
  • Immunoglobulin Heavy Constant Gamma 3 (Gm Marker) 3
  • Constant Region Of Heavy Chain Of IgG3 3
  • Immunoglobulin Gamma 3 (Gm Marker) 3
  • Secrete-Type Ig Gamma Heavy-Chain 3
  • Heavy Chain Disease Protein 4
  • C Gamma 3 3
  • IgG3 3
  • HDC 4

External Ids for IGHG3 Gene

Previous GeneCards Identifiers for IGHG3 Gene

  • GC14M103270
  • GC14U900162
  • GC14M104203
  • GC14M104148
  • GC14M104151
  • GC14M105246
  • GC14M105303
  • GC14M105255
  • GC14M106231
  • GC14M086364

Summaries for IGHG3 Gene

GeneCards Summary for IGHG3 Gene

IGHG3 (Immunoglobulin Heavy Constant Gamma 3 (G3m Marker)) is a Protein Coding gene. Diseases associated with IGHG3 include heavy chain disease and relapsing-remitting multiple sclerosis. Among its related pathways are Creation of C4 and C2 activators and Fcgamma receptor (FCGR) dependent phagocytosis. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

Gene Wiki entry for IGHG3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHG3 Gene

Genomics for IGHG3 Gene

Genomic Location for IGHG3 Gene

105,765,914 bp from pter
106,038,345 bp from pter
272,432 bases
Minus strand

Genomic View for IGHG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGHG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG3 Gene

No data available for Regulatory Elements for IGHG3 Gene

Proteins for IGHG3 Gene

  • Protein details for IGHG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ig gamma-3 chain C region
    Protein Accession:
    Secondary Accessions:
    • A2NU35

    Protein attributes for IGHG3 Gene

    377 amino acids
    Molecular mass:
    41287 Da
    Quaternary structure:
    • Homodimer.
    • The hinge region in gamma-3 chains is about 4 times as long as in other gamma chains and contains 3 identical 15-residue segments preceded by a similar 17-residue segment (12-28)

neXtProt entry for IGHG3 Gene

Proteomics data for IGHG3 Gene at MOPED

Post-translational modifications for IGHG3 Gene

  • Glycosylation at Asn227
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHG3 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGHG3 Gene

Domains for IGHG3 Gene

Gene Families for IGHG3 Gene

Protein Domains for IGHG3 Gene

Suggested Antigen Peptide Sequences for IGHG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHG3: view

No data available for UniProtKB/Swiss-Prot for IGHG3 Gene

Function for IGHG3 Gene

Molecular function for IGHG3 Gene

GENATLAS Biochemistry:
immunoglobulin,gamma 3 (Gm marker)

Gene Ontology (GO) - Molecular Function for IGHG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGHG3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHG3 Gene

Localization for IGHG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG3 Gene


Subcellular locations from

Jensen Localization Image for IGHG3 Gene COMPARTMENTS Subcellular localization image for IGHG3 gene
Compartment Confidence
extracellular 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for IGHG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22664934
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGHG3: view

Pathways for IGHG3 Gene

genes like me logo Genes that share pathways with IGHG3: view

Interacting Proteins for IGHG3 Gene

Selected Interacting proteins: P01860-IGHG3_HUMAN for IGHG3 Gene via MINT I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for IGHG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with IGHG3: view

Transcripts for IGHG3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG3 Gene

No ASD Table

Relevant External Links for IGHG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHG3 Gene

mRNA expression in normal human tissues for IGHG3 Gene

mRNA differential expression in normal tissues according to GTEx for IGHG3 Gene

This gene is overexpressed in Spleen (25.0) and Lung (4.2).

Protein differential expression in normal tissues for IGHG3 Gene

This gene is overexpressed in Plasma (9.9) and Serum (9.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGHG3 Gene

genes like me logo Genes that share expressions with IGHG3: view

Expression partners for IGHG3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHG3 Gene

Orthologs for IGHG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
(Mus musculus)
Mammalia Ighg1 36
  • 64 (a)
Ighg2b 36
  • 59 (a)
Ighg2c 36
  • 49 (a)
Ighg3 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
-- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
(Danio rerio)
Actinopterygii ighv1-4 36
  • 15 (a)
Species with no ortholog for IGHG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHG3 Gene

Gene Tree for IGHG3 (if available)
Gene Tree for IGHG3 (if available)

Paralogs for IGHG3 Gene

Paralogs for IGHG3 Gene

genes like me logo Genes that share paralogs with IGHG3: view

Variants for IGHG3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHG3 Gene

The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths. Variant WIS is lacking most of the V region and all of the CH1 region. It has an extra interchain disulfide bond at position 7 in addition to the 11 normally present in the hinge region. Variant ZUC lacks most of the V region, all of the CH1 region, and part of the hinge. Variant OMM may represent an allelic form or another gamma chain subclass

Sequence variations from dbSNP and Humsavar for IGHG3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_003890 -
VAR_003891 -
VAR_003892 -
VAR_003893 -
VAR_003894 -

Relevant External Links for IGHG3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Structural Variations from Database of Genomic Variants (DGV) for IGHG3 Gene

Disorders for IGHG3 Gene

Relevant External Links for IGHG3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IGHG3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for IGHG3 Gene

Publications for IGHG3 Gene

  1. Gamma heavy chain disease in man: cDNA sequence supports partial gene deletion model. (PMID: 6808505) Alexander A. … Buxbaum J.N. (Proc. Natl. Acad. Sci. U.S.A. 1982) 2 3 4
  2. Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis. (PMID: 6774747) Frangione B. … Franklin E.C. (Biochemistry 1980) 3 4
  3. The amino acid sequence of 'heavy chain disease' protein ZUC. Structure of the Fc fragment of immunoglobulin G3. (PMID: 823945) Wolfenstein-Todel C. … Franklin E.C. (Biochem. Biophys. Res. Commun. 1976) 3 4
  4. Primary structure of the 'hinge' region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit. (PMID: 402363) Michaelsen T.E. … Franklin E.C. (J. Biol. Chem. 1977) 3 4
  5. Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes. (PMID: 3081877) Huck S. … Lefranc G. (Nucleic Acids Res. 1986) 3 4

Products for IGHG3 Gene

Sources for IGHG3 Gene

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