Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IGHG3 Gene

protein-coding   GIFtS: 45
GCID: GC14M106231

Immunoglobulin Heavy Constant Gamma 3 (G3m Marker)

  See IGHG3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Immunoglobulin Heavy Constant Gamma 3 (G3m Marker)1 2
IgG32
HDC3
Heavy Chain Disease Protein3

External Ids:    HGNC: 55271   Entrez Gene: 35022   Ensembl: ENSG000002118977   OMIM: 1471205   UniProtKB: P018603   

Export aliases for IGHG3 gene to outside databases

Previous GC identifers: GC14M103270 GC14U900162 GC14M104203 GC14M104148 GC14M104151 GC14M105246 GC14M105303 GC14M105255 GC14M086364


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for IGHG3 Gene:
IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)) is a protein-coding gene. Diseases associated with IGHG3 include heavy chain disease, and gamma heavy chain disease. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.

Gene Wiki entry for IGHG3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Search for regulatory transcription factor binding sites for IGHG3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGHG3 promoter sequence
   Search Chromatin IP Primers for IGHG3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGHG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHG3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106231:  view genomic region     (about GC identifiers)

Start:
106,232,251 bp from pter      End:
106,237,742 bp from pter
Size:
5,492 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IGHG3_HUMAN, P01860 (See protein sequence)
Recommended Name: Ig gamma-3 chain C region  
Size: 377 amino acids; 41287 Da
Subunit: Homodimer
Miscellaneous: The hinge region in gamma-3 chains is about 4 times as long as in other gamma chains and contains 3
identical 15-residue segments preceded by a similar 17-residue segment (12-28)
Secondary accessions: A2NU35

Explore the universe of human proteins at neXtProt for IGHG3: NX_P01860

Explore proteomics data for IGHG3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn227

  • See IGHG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000374993  
    Reactome Protein details: P01860

    IGHG3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IGHG3
    GenScript Custom Purified and Recombinant Proteins Services for IGHG3
    Novus Biologicals IGHG3 Protein
    Novus Biologicals IGHG3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IGHG3 

     
    antibodies-online proteins for IGHG3 (5 products) 

     
    antibodies-online peptides for IGHG3

    IGHG3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IGHG3
    Novus Biologicals IGHG3 Antibodies
    Abcam antibodies for IGHG3
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for IGHG3
    antibodies-online antibodies for IGHG3 (8 products) 

    IGHG3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IGHG3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IGHG3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for IGHG3: (see all 2
                        Human IgG3 Platinum ELISA 96 tests
    antibodies-online kits for IGHG3 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IGH: Immunoglobulins / IGH locus

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01860

    ProtoNet protein and cluster: P01860

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type


    Find genes that share domains with IGHG3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for IGHG3:
    immunoglobulin,gamma 3 (Gm marker)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IGHG3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IGHG3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IGHG3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IGHG3
    SwitchGear 3'UTR luciferase reporter plasmidIGHG3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse OriGene RNAi
    Predesigned siRNA for gene silencing in human, mouse, rat IGHG3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IGHG3

    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGHG3
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGHG3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHG3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IGHG3
    Browse ESI BIO Cell Lines and PureStem Progenitors for IGHG3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHG3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IGHG3_HUMAN, P01860: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with IGHG3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IGHG3 About    
    See pathways by source

    SuperPathContained pathways About
    1Creation of C4 and C2 activators
    Creation of C4 and C2 activators0.85
    Complement cascade0.68
    Initial triggering of complement0.85
    FCGR activation0.54
    Classical antibody-mediated complement activation0.82
    Role of phospholipids in phagocytosis0.53
    2Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    3Immune response Role of DAP12 receptors in NK cells
    Immune response CD16 signaling in NK cells0.33
    4IL4-mediated signaling events
    IL4-mediated signaling events


    Find genes that share SuperPaths with IGHG3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for IGHG3
        Immune response CD16 signaling in NK cells

    1 BioSystems Pathway for IGHG3
        IL4-mediated signaling events

    5 Reactome Pathways for IGHG3
        Classical antibody-mediated complement activation
    Regulation of actin dynamics for phagocytic cup formation
    FCGR activation
    Role of phospholipids in phagocytosis
    Initial triggering of complement


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGHG3
    Interactions:

        Search GeneGlobe Interaction Network for IGHG3

    1 Interacting protein for IGHG3 (P018602, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K92, 3MINT-48135 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001895retina homeostasis IEP--
    GO:0006956complement activation TAS--
    GO:0006958complement activation, classical pathway TAS--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with IGHG3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGHG3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390551(uc001ysh.1 uc001ysi.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IGHG3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IGHG3
    SwitchGear 3'UTR luciferase reporter plasmidIGHG3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse OriGene RNAi
    Predesigned siRNA for gene silencing in human, mouse, rat IGHG3
    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGHG3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGHG3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHG3
    Primer
    Products:
        
    Browse OriGene qPCR
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IGHG3
      QuantiTect SYBR Green Assays in human, mouse, rat IGHG3
      QuantiFast Probe-based Assays in human, mouse, rat IGHG3

    Selected AceView cDNA sequences (see all 413):

    BX455850 CR612308 BM987706 BU616028 BU615960 CR598566 AW516022 CR611790 
    CR603657 CR607337 BU615732 CR605127 CR619232 CR613511 CA426007 CR608756 
    CR598316 CR601777 BU616690 CA447627 CR608083 AW002798 BU616371 BX414017 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IGHG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGHG3 Expression
    About this image

    IGHG3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGHG3 Protein Expression
        Custom PCR Arrays for IGHG3
    Primer
    Products:
    Browse OriGene qPCR
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IGHG3
    QuantiTect SYBR Green Assays in human, mouse, rat IGHG3
    QuantiFast Probe-based Assays in human, mouse, rat IGHG3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for IGHG3 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    26(a)
    1 → many
    GL343491.1(461752-525278)
    zebrafish
    (Danio rerio)
    Actinopterygii ighv1-46
    immunoglobulin heavy variable 1-4
    15(a)
    1 → many
    3(34048543-34145418) ENSDARG00000096355
            Species with no ortholog for IGHG3

    ENSEMBL Gene Tree for IGHG3 (if available)
    TreeFam Gene Tree for IGHG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IGHG3 gene
    IGHG22  IGHE2  IGHA12  IGHM2  IGHG42  IGHG12  IGHA22  
    Selected SIMAP similar genes for IGHG3 using alignment to 1 protein entry:     IGHG3_HUMAN(see all similar genes):
    DKFZp686I15212    FLJ00385    VHCH1    DKFZp686E23209    DKFZp686G11190    DKFZp686H20196
    DKFZp686I04196    DKFZp686I15196    DKFZp686N02209    DKFZp686O01196    DKFZp686P15220    IGH@
    IGHG1    DKFZp686C11235    DKFZp686C15213    DKFZp686K03196    DKFZp686M24218    IGHG2

    Find genes that share paralogs with IGHG3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    IGHG3_HUMAN, P01860: The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths. Variant WIS
    is lacking most of the V region and all of the CH1 region. It has an extra interchain disulfide bond at position
    7 in addition to the 11 normally present in the hinge region. Variant ZUC lacks most of the V region, all of the
    CH1 region, and part of the hinge. Variant OMM may represent an allelic form or another gamma chain subclass


    10 SNPs for IGHG3    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0686994
    ----see VAR_0686992 D N mis40--------
    VAR_0038904
    ----see VAR_0038902 V B mis40--------
    VAR_0038914
    ----see VAR_0038912 P L mis40--------
    VAR_0038944
    ----see VAR_0038942 S N mis40--------
    VAR_0686974
    ----see VAR_0686972 E Q mis40--------
    VAR_0038934
    ----see VAR_0038932 T A mis40--------
    VAR_0038924
    ----see VAR_0038922 Y F mis40--------
    VAR_0686984
    ----see VAR_0686982 E Q mis40--------
    VAR_0038964
    ----see VAR_0038962 F Y mis40--------
    VAR_0687004
    ----see VAR_0687002 N D mis40--------

    HapMap Linkage Disequilibrium report for IGHG3 (106232251 - 106237742 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IGHG3: --
    Human Gene Mutation Database (HGMD): IGHG3
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGHG3
    DNA2.0 Custom Variant and Variant Library Synthesis for IGHG3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 147120    OMIM disorders: --

    5 diseases for IGHG3:    
    About MalaCards
    heavy chain disease    gamma heavy chain disease    relapsing-remitting multiple sclerosis    bullous pemphigoid
    hepatitis a


    Find genes that share disorders with IGHG3           About GenesLikeMe

    Genetic Association Database (GAD): IGHG3
    Human Genome Epidemiology (HuGE) Navigator: IGHG3 (1 document)

    Export disorders for IGHG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IGHG3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with IGHG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma heavy chain disease in man: cDNA sequence supports partial gene deletion model. (PubMed id 6808505)1, 2, 3 Alexander A.... Buxbaum J.N. (Proc. Natl. Acad. Sci. U.S.A. 1982)
    2. Association between Gm allotypes and asthma severity from childhood to young middle age. (PubMed id 17933503)1, 4 Gustafsson P.M....Kjellman B. (Respir Med 2008)
    3. Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes. (PubMed id 3081877)1, 2 Huck S.... Lefranc G. (Nucleic Acids Res. 1986)
    4. Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis. (PubMed id 6774747)1, 2 Frangione B.... Franklin E.C. (Biochemistry 1980)
    5. Primary structure of the 'hinge' region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit. (PubMed id 402363)1, 2 Michaelsen T.E.... Franklin E.C. (J. Biol. Chem. 1977)
    6. The amino acid sequence of 'heavy chain disease' protein ZUC. Structure of the Fc fragment of immunoglobulin G3. (PubMed id 823945)1, 2 Wolfenstein-Todel C.... Franklin E.C. (Biochem. Biophys. Res. Commun. 1976)
    7. Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis. (PubMed id 23225573)1 Buck D....Hemmer B. (Ann. Neurol. 2013)
    8. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Immunoglobulin GM genes as functional risk and protective factors for the development of Alzheimer's disease. (PubMed id 19542624)1 Pandey J.P. (J. Alzheimers Dis. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3502 HGNC: 5527 AceView: IGHD_ Ensembl:ENSG00000211897 euGenes: HUgn3502
    ECgene: IGHG3 H-InvDB: IGHG3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IGHG3 Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGHG3 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHG3&species=Homo+sapiens

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IGHG3 gene:
    Search GeneIP for patents involving IGHG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   Browse OriGene RNAi products  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   Browse OriGene clones  
     Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IGHG3   OriGene Custom Protein Services for IGHG3  

     
     
     Block miRNA regulation of human, mouse, rat IGHG3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IGHG3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGHG3 Predesigned siRNA for gene silencing in human, mouse, rat IGHG3
     QuantiFast Probe-based Assays in human, mouse, rat IGHG3 QuantiTect SYBR Green Assays in human, mouse, rat IGHG3
     Custom PCR Arrays for IGHG3 Search Chromatin IP Primers for IGHG3
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IGHG3 Search GeneGlobe Interaction Network for IGHG3
     Search Regulatory tfbs for IGHG3
     GenScript Custom Purified and Recombinant Proteins Services for IGHG3 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for IGHG3
     GenScript Custom Assay Services for IGHG3 GenScript Custom overexpressing Cell Line Services for IGHG3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IGHG3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IGHG3 antibodies
     IGHG3 proteins
     IGHG3 lysates
     Antibodies for IGHG3
     See all of Abcam's Antibodies, Kits and Proteins for IGHG3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for IGHG3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHG3
     SwitchGear 3'UTR luciferase reporter plasmids for IGHG3
     SwitchGear Promoter luciferase reporter plasmids for IGHG3
     Search ThermoFisher Antibodies for IGHG3
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHG3
     Browse compounds at ApexBio
     Search Addgene for plasmids for IGHG3
      Search eBioscience for proteins for IGHG3
     eBioscience elisas for IGHG3 (Human IgG3 Platinum ELISA 96 tests)
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for IGHG3
     antibodies-online antibodies for IGHG3 (8 products)
     antibodies-online kits for IGHG3 (12 products)
     antibodies-online peptides for IGHG3
     antibodies-online proteins for IGHG3 (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IGHG3 gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4