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Aliases for IGHG2 Gene

Aliases for IGHG2 Gene

  • Immunoglobulin Heavy Constant Gamma 2 (G2m Marker) 2 3 5
  • Ig Gamma-2 Chain C Region DOT 4
  • Ig Gamma-2 Chain C Region TIL 4
  • Ig Gamma-2 Chain C Region ZIE 4
  • Ig Gamma-2 Chain C Region 4

External Ids for IGHG2 Gene

Previous GeneCards Identifiers for IGHG2 Gene

  • GC14U990036
  • GC14M100100
  • GC14M104146
  • GC14M104149
  • GC14M105180
  • GC14M106109
  • GC14M105643

Summaries for IGHG2 Gene

GeneCards Summary for IGHG2 Gene

IGHG2 (Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)) is a Protein Coding gene. Diseases associated with IGHG2 include Kappa Light Chain Deficiency and C2 Deficiency. Among its related pathways are Role of phospholipids in phagocytosis and Creation of C4 and C2 activators. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

UniProtKB/Swiss-Prot for IGHG2 Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Wiki entry for IGHG2 Gene

Additional gene information for IGHG2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHG2 Gene

Genomics for IGHG2 Gene

Genomic Location for IGHG2 Gene

Chromosome:
14
Start:
105,639,559 bp from pter
End:
105,644,790 bp from pter
Size:
5,232 bases
Orientation:
Minus strand

Genomic View for IGHG2 Gene

Genes around IGHG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG2 Gene

No data available for Regulatory Elements for IGHG2 Gene

Proteins for IGHG2 Gene

  • Protein details for IGHG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01859-IGHG2_HUMAN
    Recommended name:
    Immunoglobulin heavy constant gamma 2
    Protein Accession:
    P01859
    Secondary Accessions:
    • A6NE66

    Protein attributes for IGHG2 Gene

    Size:
    326 amino acids
    Molecular mass:
    35901 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    SequenceCaution:
    • Sequence=AAB59393.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHG2 Gene

neXtProt entry for IGHG2 Gene

Post-translational modifications for IGHG2 Gene

  • Glycosylation at posLast=176176
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHG2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHG2 Gene

Domains & Families for IGHG2 Gene

Gene Families for IGHG2 Gene

Protein Domains for IGHG2 Gene

Suggested Antigen Peptide Sequences for IGHG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHG2: view

No data available for UniProtKB/Swiss-Prot for IGHG2 Gene

Function for IGHG2 Gene

Molecular function for IGHG2 Gene

GENATLAS Biochemistry:
immunoglobulin,gamma 2 (Gm marker)
UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 16457820
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGHG2: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGHG2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHG2 Gene

Localization for IGHG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG2 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGHG2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGHG2 Gene

Pathways & Interactions for IGHG2 Gene

genes like me logo Genes that share pathways with IGHG2: view

Interacting Proteins for IGHG2 Gene

Selected Interacting proteins: P01859-IGHG2_HUMAN for IGHG2 Gene via IID UniProtKB

Symbol External ID(s) Details
HLA-B
HLA-DRB1
HLA-A
HLA-C
- (XENO)

Gene Ontology (GO) - Biological Process for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGHG2: view

No data available for SIGNOR curated interactions for IGHG2 Gene

Drugs & Compounds for IGHG2 Gene

(9) Drugs for IGHG2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACID Experimental Pharma Target 0
3-(HYDROXY-PHENYL-PHOSPHINOYLOXY)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER Experimental Pharma Target 0
3-OXO-N-[(3S)-2-OXOPYRROLIDIN-3-YL]DODECANAMIDE Experimental Pharma Target 0
4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE Experimental Pharma Target 0
5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGHG2: view

Transcripts for IGHG2 Gene

mRNA/cDNA for IGHG2 Gene

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGHG2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG2 Gene

No ASD Table

Relevant External Links for IGHG2 Gene

GeneLoc Exon Structure for
IGHG2
ECgene alternative splicing isoforms for
IGHG2

Expression for IGHG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGHG2 Gene

mRNA differential expression in normal tissues according to GTEx for IGHG2 Gene

This gene is overexpressed in Spleen (x33.9).

Protein differential expression in normal tissues from HIPED for IGHG2 Gene

This gene is overexpressed in Serum (7.9) and Cerebrospinal fluid (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHG2 Gene



Protein tissue co-expression partners for IGHG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGHG2 Gene:

IGHG2

Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHG2 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
Organs:
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with IGHG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for IGHG2 Gene

Orthologs for IGHG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ighg1 34
  • 64 (a)
ManyToMany
Ighg3 34
  • 62 (a)
ManyToMany
Ighg2b 34
  • 58 (a)
ManyToMany
Ighg2c 34
  • 49 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 25 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 34
  • 14 (a)
OneToMany
Species where no ortholog for IGHG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHG2 Gene

ENSEMBL:
Gene Tree for IGHG2 (if available)
TreeFam:
Gene Tree for IGHG2 (if available)

Paralogs for IGHG2 Gene

Variants for IGHG2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHG2 Gene

IGHG2_HUMAN-P01859
There are several alleles. The sequence shown is that of IMGT allele IGHG2*06.

Sequence variations from dbSNP and Humsavar for IGHG2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_003889 --
VAR_077892 --

Relevant External Links for IGHG2 Gene

Human Gene Mutation Database (HGMD)
IGHG2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHG2

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHG2 Gene

Disorders for IGHG2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IGHG2 Gene - From: HGMD, Orphanet, and GeneCards

Disorder Aliases PubMed IDs
kappa light chain deficiency
  • kappa chain deficiency
c2 deficiency
  • complement component 2 deficiency
- elite association - COSMIC cancer census association via MalaCards
Search IGHG2 in MalaCards View complete list of genes associated with diseases

Genatlas disease for IGHG2 Gene

IGG2 deficiency caused by a mutated membrane-bound form of gamma 2 heavy chain,with recurrent sino-pulmonary infections

Relevant External Links for IGHG2

Genetic Association Database (GAD)
IGHG2
Human Genome Epidemiology (HuGE) Navigator
IGHG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGHG2
genes like me logo Genes that share disorders with IGHG2: view

No data available for UniProtKB/Swiss-Prot for IGHG2 Gene

Publications for IGHG2 Gene

  1. Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies. (PMID: 18821675) O'Hanlon TP … Miller FW (Arthritis and rheumatism 2008) 3 45 60
  2. A proteomic analysis of human bile. (PMID: 15084671) Kristiansen TZ … Pandey A (Molecular & cellular proteomics : MCP 2004) 3 4 60
  3. Characterization of the two unique human anti-flavin monoclonal immunoglobulins. (PMID: 7737190) Stoppini M … Ferri G (European journal of biochemistry 1995) 3 4 60
  4. Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. (PMID: 6811139) Takahashi N … Honjo T (Cell 1982) 3 4 60
  5. Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. (PMID: 6804948) Ellison J … Hood L (Proceedings of the National Academy of Sciences of the United States of America 1982) 3 4 60

Products for IGHG2 Gene

Sources for IGHG2 Gene

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