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Aliases for IGHG2 Gene

Aliases for IGHG2 Gene

  • Immunoglobulin Heavy Constant Gamma 2 (G2m Marker) 2 3 5

External Ids for IGHG2 Gene

Previous GeneCards Identifiers for IGHG2 Gene

  • GC14U990036
  • GC14M100100
  • GC14M104146
  • GC14M104149
  • GC14M105180
  • GC14M106109

Summaries for IGHG2 Gene

GeneCards Summary for IGHG2 Gene

IGHG2 (Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)) is a Protein Coding gene. Diseases associated with IGHG2 include Kappa Light Chain Deficiency and C2 Deficiency. Among its related pathways are Immune System and Creation of C4 and C2 activators. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

Gene Wiki entry for IGHG2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHG2 Gene

Genomics for IGHG2 Gene

Regulatory Elements for IGHG2 Gene

Enhancers for IGHG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F105646 0.7 Ensembl 0.8 -2.9 -2911 3.0 SCRT1 MAZ MTA2 EBF1 REST ATF2 ZFHX2 POLR2A SCRT2 IKZF1 TMEM121 ENSG00000257270 ENSG00000253364 IGHG2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGHG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHG2 Gene

Chromosome:
14
Start:
105,643,052 bp from pter
End:
105,644,790 bp from pter
Size:
1,739 bases
Orientation:
Minus strand

Genomic View for IGHG2 Gene

Genes around IGHG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG2 Gene

Proteins for IGHG2 Gene

  • Protein details for IGHG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01859-IGHG2_HUMAN
    Recommended name:
    Ig gamma-2 chain C region
    Protein Accession:
    P01859
    Secondary Accessions:
    • A6NE66

    Protein attributes for IGHG2 Gene

    Size:
    326 amino acids
    Molecular mass:
    35901 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IGHG2 Gene

neXtProt entry for IGHG2 Gene

Post-translational modifications for IGHG2 Gene

  • Glycosylation at Asn 176
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHG2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHG2 Gene

Domains & Families for IGHG2 Gene

Gene Families for IGHG2 Gene

Protein Domains for IGHG2 Gene

Suggested Antigen Peptide Sequences for IGHG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHG2: view

No data available for UniProtKB/Swiss-Prot for IGHG2 Gene

Function for IGHG2 Gene

Molecular function for IGHG2 Gene

GENATLAS Biochemistry:
immunoglobulin,gamma 2 (Gm marker)

Gene Ontology (GO) - Molecular Function for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 16457820
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGHG2: view

Human Phenotype Ontology for IGHG2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHG2 Gene

Localization for IGHG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 22664934
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with IGHG2: view

No data available for Subcellular locations from COMPARTMENTS for IGHG2 Gene

Pathways & Interactions for IGHG2 Gene

genes like me logo Genes that share pathways with IGHG2: view

Interacting Proteins for IGHG2 Gene

Selected Interacting proteins: P01859-IGHG2_HUMAN for IGHG2 Gene via IID UniProtKB

Symbol External ID(s) Details
HLA-B
HLA-DRB1
HLA-A
HLA-C
- (XENO)

Gene Ontology (GO) - Biological Process for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway IBA,TAS --
genes like me logo Genes that share ontologies with IGHG2: view

No data available for SIGNOR curated interactions for IGHG2 Gene

Drugs & Compounds for IGHG2 Gene

(9) Drugs for IGHG2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACID Experimental Pharma Target 0
3-(HYDROXY-PHENYL-PHOSPHINOYLOXY)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER Experimental Pharma Target 0
3-OXO-N-[(3S)-2-OXOPYRROLIDIN-3-YL]DODECANAMIDE Experimental Pharma Target 0
4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE Experimental Pharma Target 0
5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGHG2: view

Transcripts for IGHG2 Gene

mRNA/cDNA for IGHG2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG2 Gene

No ASD Table

Relevant External Links for IGHG2 Gene

GeneLoc Exon Structure for
IGHG2
ECgene alternative splicing isoforms for
IGHG2

Expression for IGHG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGHG2 Gene

mRNA differential expression in normal tissues according to GTEx for IGHG2 Gene

This gene is overexpressed in Spleen (x33.9).

Protein differential expression in normal tissues from HIPED for IGHG2 Gene

This gene is overexpressed in Serum (7.9) and Cerebrospinal fluid (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHG2 Gene



Protein tissue co-expression partners for IGHG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGHG2 Gene:

IGHG2
genes like me logo Genes that share expression patterns with IGHG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHG2 Gene

Orthologs for IGHG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ighg1 35
  • 64 (a)
ManyToMany
Ighg3 35
  • 62 (a)
ManyToMany
Ighg2b 35
  • 58 (a)
ManyToMany
Ighg2c 35
  • 49 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 43 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 25 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 35
  • 14 (a)
OneToMany
Species where no ortholog for IGHG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHG2 Gene

ENSEMBL:
Gene Tree for IGHG2 (if available)
TreeFam:
Gene Tree for IGHG2 (if available)

Paralogs for IGHG2 Gene

Variants for IGHG2 Gene

Sequence variations from dbSNP and Humsavar for IGHG2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_003889 --

Relevant External Links for IGHG2 Gene

Human Gene Mutation Database (HGMD)
IGHG2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHG2 Gene

Disorders for IGHG2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IGHG2 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
kappa light chain deficiency
  • immunoglobulin kappa light chain deficiency
c2 deficiency
  • complement component 2 deficiency
- elite association - COSMIC cancer census association via MalaCards
Search IGHG2 in MalaCards View complete list of genes associated with diseases

Genatlas disease for IGHG2 Gene

IGG2 deficiency caused by a mutated membrane-bound form of gamma 2 heavy chain,with recurrent sino-pulmonary infections

Relevant External Links for IGHG2

Genetic Association Database (GAD)
IGHG2
Human Genome Epidemiology (HuGE) Navigator
IGHG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGHG2
genes like me logo Genes that share disorders with IGHG2: view

No data available for UniProtKB/Swiss-Prot for IGHG2 Gene

Publications for IGHG2 Gene

  1. Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies. (PMID: 18821675) O'Hanlon T.P. … Miller F.W. (Arthritis Rheum. 2008) 3 46 64
  2. A proteomic analysis of human bile. (PMID: 15084671) Kristiansen T.Z. … Pandey A. (Mol. Cell. Proteomics 2004) 3 4 64
  3. Characterization of the two unique human anti-flavin monoclonal immunoglobulins. (PMID: 7737190) Stoppini M. … Ferri G. (Eur. J. Biochem. 1995) 3 4 64
  4. Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes. (PMID: 6329676) Krawinkel U. … Rabbitts T.H. (EMBO J. 1982) 3 4 64
  5. Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. (PMID: 6804948) Ellison J.W. … Hood L.E. (Proc. Natl. Acad. Sci. U.S.A. 1982) 3 4 64

Products for IGHG2 Gene

Sources for IGHG2 Gene

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