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IGHG2 Gene

protein-coding   GIFtS: 45
GCID: GC14M106109

Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)

  See IGHG2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)1 2

External Ids:    HGNC: 55261   Entrez Gene: 35012   Ensembl: ENSG000002118937   OMIM: 1471105   UniProtKB: P018593   

Export aliases for IGHG2 gene to outside databases

Previous GC identifers: GC14U990036 GC14M100100 GC14M104146 GC14M104149 GC14M105180


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGHG2 Gene:
IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)) is a protein-coding gene. Diseases associated with IGHG2 include sarcomatosis, and congenital hypogammaglobulinemia. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHE.

Gene Wiki entry for IGHG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IGHG2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IGHG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGHG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHG2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106109:  view genomic region     (about GC identifiers)

Start:
106,109,389 bp from pter      End:
106,111,127 bp from pter
Size:
1,739 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IGHG2_HUMAN, P01859 (See protein sequence)
Recommended Name: Ig gamma-2 chain C region  
Size: 326 amino acids; 35901 Da
4 PDB 3D structures from and Proteopedia for IGHG2:
2QSC (3D)        4HAF (3D)        4HAG (3D)        4L4J (3D)    
Secondary accessions: A6NE66

Explore the universe of human proteins at neXtProt for IGHG2: NX_P01859

Explore proteomics data for IGHG2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn176
  • Modification sites at PhosphoSitePlus

  • See IGHG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000374987  
    Reactome Protein details: P01859

    IGHG2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IGHG2 

     
    antibodies-online proteins for IGHG2 (2 products) 

     
    Search antibodies-online for peptides for IGHG2

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    Search eBioscience for ELISAs for IGHG2 
    antibodies-online kits for IGHG2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGH: Immunoglobulins / IGH locus

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01859

    ProtoNet protein and cluster: P01859

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type


    Find genes that share domains with IGHG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for IGHG2:
    immunoglobulin,gamma 2 (Gm marker)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IEA--
    GO:0005515protein binding IPI16457820
         
    Find genes that share ontologies with IGHG2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IGHG2

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGHG2_HUMAN, P01859: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion2
    plasma membrane2
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0016020membrane ----
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with IGHG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGHG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Creation of C4 and C2 activators
    Creation of C4 and C2 activators0.85
    Complement cascade0.68
    Initial triggering of complement0.85
    FCGR activation0.54
    Classical antibody-mediated complement activation0.82
    Role of phospholipids in phagocytosis0.53
    2Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77


    Find genes that share SuperPaths with IGHG2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 Reactome Pathways for IGHG2
        Classical antibody-mediated complement activation
    Regulation of actin dynamics for phagocytic cup formation
    FCGR activation
    Role of phospholipids in phagocytosis
    Initial triggering of complement


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGHG2
    Interactions:

        Search GeneGlobe Interaction Network for IGHG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IGHG2 (P018591, 2, 3 ENSP000003749874) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USF2Q158533, ENSP000002223054I2D: score=1 STRING: ENSP00000222305
    IGKCP018343, ENSP000003747774I2D: score=1 STRING: ENSP00000374777
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    GABARAPL1Q9H0R83I2D: score=1 
    IGLC6P0CF743I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ----
    GO:0006956complement activation TAS--
    GO:0006958complement activation, classical pathway TAS--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with IGHG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGHG2

    10 DrugBank Compounds for IGHG2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACID-- --target--10592235
    3-(HYDROXY-PHENYL-PHOSPHINOYLOXY)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER-- --target--10592235
    3-OXO-N-[(3S)-2-OXOPYRROLIDIN-3-YL]DODECANAMIDE-- --target--10592235
    4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE-- --target--10592235
    5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE-- --target--10592235
    5-BETA-ANDROSTANE-3,17-DIONE-- --target--10592235
    Aetiocholanolone-- 53-42-9target--10592235
    Alpha-D-Mannose-- 3458-28-4target--10592235
    ECGONINE METHYL ESTER-- --target--10592235
    PROGESTERONE-11-ALPHA-OL-HEMISUCCINATE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390545(uc001yrz.2)
    miRNA
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    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat IGHG2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGHG2
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat IGHG2
      QuantiFast Probe-based Assays in human, mouse, rat IGHG2

    24 AceView cDNA sequences:

    CR611470 CR603347 CR595292 CR602414 CR604840 CR612974 CR606727 CR602446 
    CR609431 CR594498 CR590214 CR603811 CR600777 CR599517 CR604209 CR623267 
    CR594421 CR594433 CR611575 BC040042 AJ294731 CR625121 CR592363 AK128421 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGHG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGHG2 Expression
    About this image


    IGHG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    IGHG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGHG2 Protein Expression
        Custom PCR Arrays for IGHG2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGHG2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    1 → many
    GL343491.1(461752-525278)
    zebrafish
    (Danio rerio)
    Actinopterygii ighv1-46
    immunoglobulin heavy variable 1-4
    14(a)
    1 → many
    3(34048543-34145418) ENSDARG00000096355
            Species with no ortholog for IGHG2

    ENSEMBL Gene Tree for IGHG2 (if available)
    TreeFam Gene Tree for IGHG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGHG2 gene
    IGHE2  IGHA12  IGHM2  IGHG32  IGHG42  IGHG12  IGHA22  
    Selected SIMAP similar genes for IGHG2 using alignment to 1 protein entry:     IGHG2_HUMAN(see all similar genes):
    DKFZp686C15213    DKFZp686E23209    DKFZp686I04196    DKFZp686M24218    IGHG4    DKFZp686C11235
    DKFZp686G11190    DKFZp686H20196    DKFZp686I15196    DKFZp686K03196    DKFZp686N02209    DKFZp686O01196
    DKFZp686P15220    IGH@    IGHG1    VHCH1    DKFZp686I15212    FLJ00385

    Find genes that share paralogs with IGHG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for IGHG2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0038894
    ----see VAR_0038892 S A mis40--------

    HapMap Linkage Disequilibrium report for IGHG2 (106109389 - 106111127 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IGHG2: --
    Human Gene Mutation Database (HGMD): IGHG2
    Locus Specific Mutation Databases (LSDB): IGHG2

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGHG2
    DNA2.0 Custom Variant and Variant Library Synthesis for IGHG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147110    OMIM disorders: --

    4 diseases for IGHG2:    
    About MalaCards
    sarcomatosis    congenital hypogammaglobulinemia    igg2 deficiency, selective    recurrent infections associated with rare immunoglobulin isotypes deficiency

    2 diseases from the University of Copenhagen DISEASES database for IGHG2:
    Congenital hypogammaglobulinemia     Sarcomatosis

    Find genes that share disorders with IGHG2           About GenesLikeMe

    Genatlas disease: IGHG2
    IGG2 deficiency caused by a mutated membrane-bound form of gamma 2 heavy chain,with recurrent sino-pulmonary
    infections

    Genetic Association Database (GAD): IGHG2
    Human Genome Epidemiology (HuGE) Navigator: IGHG2 (1 document)

    Export disorders for IGHG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGHG2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with IGHG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies. (PubMed id 18821675)1, 4 O'Hanlon T.P....Miller F.W. (Arthritis Rheum. 2008)
    2. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (Mol. Cell. Proteomics 2004)
    3. Characterization of the two unique human anti-flavin monoclonal immunoglobulins. (PubMed id 7737190)1, 2 Stoppini M.... Ferri G. (Eur. J. Biochem. 1995)
    4. Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. (PubMed id 6804948)1, 2 Ellison J.W. and Hood L.E. (Proc. Natl. Acad. Sci. U.S.A. 1982)
    5. Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes. (PubMed id 6329676)1, 2 Krawinkel U. and Rabbitts T.H. (EMBO J. 1982)
    6. Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. (PubMed id 6811139)1, 2 Takahashi N.... Honjo T. (Cell 1982)
    7. The primary structure of a human IgG2 heavy chain: genetic, evolutionary, and functional implications. (PubMed id 6774012)1, 2 Wang A.-C.... Fudenberg H.H. (J. Immunol. 1980)
    8. The amino acid sequences of the three heavy chain constant region domains of a human IgG2 myeloma protein. (PubMed id 113060)1, 2 Connell G.E.... Hofmann T. (Can. J. Biochem. 1979)
    9. A note of the amino acid sequence of residues 381-391 of human immunoglobulins gamma chains. (PubMed id 118920)1, 2 Hofmann T. and Parr D.M. (Mol. Immunol. 1979)
    10. Disulphide bridges of the heavy chain of human immunoglobulin G2. (PubMed id 4940472)1, 2 Milstein C. and Frangione B. (Biochem. J. 1971)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3501 HGNC: 5526 AceView: IGHG2andIGHGP Ensembl:ENSG00000211893 euGenes: HUgn3501
    ECgene: IGHG2 H-InvDB: IGHG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGHG2 Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGHG2 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IGHG2basehttp://bioinf.uta.fi/IGHG2base/
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHG2&species=Homo+sapiens

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