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Aliases for IGHG2 Gene

Aliases for IGHG2 Gene

  • Immunoglobulin Heavy Constant Gamma 2 (G2m Marker) 2 3

External Ids for IGHG2 Gene

Previous GeneCards Identifiers for IGHG2 Gene

  • GC14U990036
  • GC14M100100
  • GC14M104146
  • GC14M104149
  • GC14M105180
  • GC14M106109

Summaries for IGHG2 Gene

GeneCards Summary for IGHG2 Gene

IGHG2 (Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)) is a Protein Coding gene. Diseases associated with IGHG2 include sarcomatosis and congenital hypogammaglobulinemia. Among its related pathways are Creation of C4 and C2 activators and Fcgamma receptor (FCGR) dependent phagocytosis. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

Gene Wiki entry for IGHG2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHG2 Gene

Genomics for IGHG2 Gene

Genomic Location for IGHG2 Gene

105,643,052 bp from pter
105,644,790 bp from pter
1,739 bases
Minus strand

Genomic View for IGHG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGHG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG2 Gene

No data available for Regulatory Elements for IGHG2 Gene

Proteins for IGHG2 Gene

  • Protein details for IGHG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ig gamma-2 chain C region
    Protein Accession:
    Secondary Accessions:
    • A6NE66

    Protein attributes for IGHG2 Gene

    326 amino acids
    Molecular mass:
    35901 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IGHG2 Gene

neXtProt entry for IGHG2 Gene

Proteomics data for IGHG2 Gene at MOPED

Post-translational modifications for IGHG2 Gene

  • Glycosylation at Asn176
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHG2 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGHG2 Gene

Domains for IGHG2 Gene

Gene Families for IGHG2 Gene

Protein Domains for IGHG2 Gene

Suggested Antigen Peptide Sequences for IGHG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHG2: view

No data available for UniProtKB/Swiss-Prot for IGHG2 Gene

Function for IGHG2 Gene

Molecular function for IGHG2 Gene

GENATLAS Biochemistry:
immunoglobulin,gamma 2 (Gm marker)

Gene Ontology (GO) - Molecular Function for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
GO:0005515 protein binding IPI 16457820
genes like me logo Genes that share ontologies with IGHG2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHG2 Gene

Localization for IGHG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG2 Gene


Subcellular locations from

Jensen Localization Image for IGHG2 Gene COMPARTMENTS Subcellular localization image for IGHG2 gene
Compartment Confidence
extracellular 5
mitochondrion 2
plasma membrane 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22664934
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGHG2: view

Pathways for IGHG2 Gene

genes like me logo Genes that share pathways with IGHG2: view

Interacting Proteins for IGHG2 Gene

Gene Ontology (GO) - Biological Process for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with IGHG2: view

Drugs for IGHG2 Gene

(9) Drugbank Compounds for IGHG2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
445651 Target experimental
644013 Target experimental
16122585 Target experimental
449242 Target experimental
5289324 Target experimental
genes like me logo Genes that share compounds with IGHG2: view

Transcripts for IGHG2 Gene

mRNA/cDNA for IGHG2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG2 Gene

No ASD Table

Relevant External Links for IGHG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHG2 Gene

mRNA expression in normal human tissues for IGHG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGHG2 Gene

This gene is overexpressed in Spleen (33.9).

Protein differential expression in normal tissues for IGHG2 Gene

This gene is overexpressed in Serum (7.9) and Cerebrospinal fluid (6.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGHG2 Gene

genes like me logo Genes that share expressions with IGHG2: view

Expression partners for IGHG2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IGHG2 Gene

Orthologs for IGHG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
(Mus musculus)
Mammalia Ighg1 36
  • 64 (a)
Ighg2b 36
  • 58 (a)
Ighg2c 36
  • 49 (a)
Ighg3 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
-- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
(Danio rerio)
Actinopterygii ighv1-4 36
  • 14 (a)
Species with no ortholog for IGHG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHG2 Gene

Gene Tree for IGHG2 (if available)
Gene Tree for IGHG2 (if available)

Paralogs for IGHG2 Gene

Paralogs for IGHG2 Gene

genes like me logo Genes that share paralogs with IGHG2: view

Variants for IGHG2 Gene

Sequence variations from dbSNP and Humsavar for IGHG2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_003889 -

Relevant External Links for IGHG2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGHG2 Gene

Disorders for IGHG2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for IGHG2 Gene in MalaCards »

(3) Diseases for IGHG2 Gene

(2) University of Copenhagen DISEASES for IGHG2 Gene

Genatlas disease for IGHG2 Gene

IGG2 deficiency caused by a mutated membrane-bound form of gamma 2 heavy chain,with recurrent sino-pulmonary infections

Relevant External Links for IGHG2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IGHG2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Novoseek inferred disease relationships for IGHG2 Gene

Publications for IGHG2 Gene

  1. Disulphide bridges of the heavy chain of human immunoglobulin G2. (PMID: 4940472) Milstein C. … Frangione B. (Biochem. J. 1971) 3 4
  2. Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes. (PMID: 6329676) Krawinkel U. … Rabbitts T.H. (EMBO J. 1982) 3 4
  3. The primary structure of a human IgG2 heavy chain: genetic, evolutionary, and functional implications. (PMID: 6774012) Wang A.-C. … Fudenberg H.H. (J. Immunol. 1980) 3 4
  4. Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. (PMID: 6804948) Ellison J.W. … Hood L.E. (Proc. Natl. Acad. Sci. U.S.A. 1982) 3 4
  5. Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. (PMID: 6811139) Takahashi N. … Honjo T. (Cell 1982) 3 4

Products for IGHG2 Gene

Sources for IGHG2 Gene

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