Aliases for IGHG2 Gene
External Ids for IGHG2 Gene
Previous GeneCards Identifiers for IGHG2 Gene
GeneCards Summary for IGHG2 Gene
IGHG2 (Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)) is a Protein Coding gene. Diseases associated with IGHG2 include Kappa Light Chain Deficiency and C2 Deficiency. Among its related pathways are Role of phospholipids in phagocytosis and Innate Immune System. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.
UniProtKB/Swiss-Prot for IGHG2 Gene
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).