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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHG2 Gene

protein-coding   GIFtS: 43
GCID: GC14M106109

immunoglobulin heavy constant gamma 2 (G2m marker)
 Explore 6 diseases affiliated with
IGHG2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGHG2    

Aliases
for IGHG2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)1 2

External Ids:    HGNC: 55261   Entrez Gene: 35012   Ensembl: ENSG000002118937   OMIM: 1471105   UniProtKB: P018593   

Export aliases for IGHG2 gene to outside databases

Previous GC identifers: GC14U990036 GC14M100100 GC14M104146 GC14M104149 GC14M105180


Summaries
for IGHG2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for IGHG2


Genomic Views
for IGHG2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHG2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHG2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106109:  view genomic region     (about GC identifiers)

Start:
 106,109,389 bp from pter      End:
 106,111,127 bp from pter
Size:
 1,739 bases      Orientation:
 minus strand

Proteins
for IGHG2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IGHG2_HUMAN, P01859 (See protein sequence)
Recommended Name: Ig gamma-2 chain C region  
Size: 326 amino acids; 35901 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for IGHG2:
2QSC (3D)    
Secondary accessions: A6NE66

Explore the universe of human proteins at neXtProt for IGHG2: NX_P01859

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P01859

    • IGHG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).


    ENSEMBL proteins: 
     ENSP00000374987  
    Reactome Protein details: P01859
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005624membrane fraction ----
    GO:0016020membrane NAS--


    IGHG2 for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for IGHG2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGHG2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01859

    ProtoNet protein and cluster: P01859

    1 Blocks protein family: IPB003597 Immunoglobulin C-type


    Function
    for IGHG2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for IGHG2:
    immunoglobulin,gamma 2 (Gm marker)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGHG2
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHG2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IEA--


    IGHG2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for IGHG2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cleavage of Alpha-1-Microglobulin
    		Classical antibody-mediated complement activation0.74
    		Initial triggering of complement0.60
    		Creation of C4 and C2 activators0.70
    		Role of phospholipids in phagocytosis0.53
    		Sequestering and phosphorylation Fc gamma receptors in the lipid rafts0.66
    		Complement cascade0.47
    		FCGR activation0.65
    2Regulation of actin dynamics for phagocytic cup formation
    		Regulation of actin dynamics for phagocytic cup formation1.00
    		Fcgamma receptor (FCGR) dependent phagocytosis0.80
    		Role of myosins in phagosome formation0.80
    3Immune System
    		Immune System1.00
    		Innate Immune System0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/12        Reactome Pathways for IGHG2 (see all 12)
        Role of myosins in phagosome formation
    FCGR activation
    Fcgamma receptor (FCGR) dependent phagocytosis
    Classical antibody-mediated complement activation
    Regulation of actin dynamics for phagocytic cup formation



    IGHG2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/11 Interacting proteins for IGHG2 (P018592, 3 ENSP000003749874) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USF2Q158533, ENSP000002223054I2D: score=1 STRING: ENSP00000222305
    IGKCP018343, ENSP000003747774I2D: score=1 STRING: ENSP00000374777
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    GABARAPL1Q9H0R83I2D: score=1 
    IGLC6P0CF743I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS--
    GO:0006956complement activation TAS--
    GO:0006958complement activation, classical pathway TAS--
    GO:0045087innate immune response TAS--


    IGHG2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IGHG2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGHG2

    10 DrugBank Compounds for IGHG2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACID-- --target--10592235
    3-(HYDROXY-PHENYL-PHOSPHINOYLOXY)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER-- --target--10592235
    3-OXO-N-[(3S)-2-OXOPYRROLIDIN-3-YL]DODECANAMIDE-- --target--10592235
    4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE-- --target--10592235
    5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE-- --target--10592235
    5-BETA-ANDROSTANE-3,17-DIONE-- --target--10592235
    Aetiocholanolone-- 53-42-9target--10592235
    Alpha-D-Mannose-- 3458-28-4target--10592235
    ECGONINE METHYL ESTER-- --target--10592235
    PROGESTERONE-11-ALPHA-OL-HEMISUCCINATE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about IGHG2 

    Transcripts
    for IGHG2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390545(uc001yrz.2)

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
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    Browse OriGene siRNA
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGHG2
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGHG2
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    Primer
    Products:            		Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IGHG2
      Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGHG2
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHG2

    24 AceView cDNA sequences:

    CR590214 CR611470 CR594421 CR609431 CR603347 CR604209 CR604840 CR599517 
    CR603811 CR594433 CR602414 CR611575 CR594498 CR595292 CR612974 CR606727 
    CR600777 CR623267 CR602446 AJ294731 BC040042 CR592363 CR625121 AK128421 

    GeneLoc Exon Structure


    Expression
    for IGHG2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGHG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IGHG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGHG2
        SABiosciences Custom PCR Arrays for IGHG2
    Primer
    Products:    		Browse OriGene genome-wide validated SYBR primer pairs
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHG2

    Orthologs
    for IGHG2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IGHG2 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 25(a)
    17(a)
    		 1 ↔ many
    possible ortholog
    		 GL343491.1(517133-525212)
    GL343491.1(485127-498368)
    zebrafish
    (Danio rerio)    		 Actinopterygii ighd6
    ighz6
    		 immunoglobulin heavy constant zeta
    		 5(a)
    14(a)
    		 many ↔ many
    many ↔ many
    		 3(34034542-34046885)
    3(34079980-34083059)


    ENSEMBL Gene Tree for IGHG2 (if available)
    TreeFam Gene Tree for IGHG2 (if available) 

    Paralogs
    for IGHG2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGHG2 gene
    IGHE2  IGHG32  IGHM2  IGHA12  IGHG42  IGHG12  IGHA22  
    18/37 SIMAP similar genes for IGHG2 using alignment to 1 protein entry:     IGHG2_HUMAN(see all similar genes):
    DKFZp686C15213    DKFZp686E23209    DKFZp686I04196    DKFZp686M24218    IGHG4    DKFZp686C11235
    DKFZp686G11190    DKFZp686H20196    DKFZp686I15196    DKFZp686K03196    DKFZp686N02209    DKFZp686O01196
    DKFZp686P15220    IGH@    IGHG1    VHCH1    DKFZp686I15212    FLJ00385

    IGHG2 for paralogs           About GeneDecksing



    Genomic Variants
    for IGHG2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): IGHG2

    Locus Specific Mutation Databases (LSDB): IGHG2
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHG2
    DNA2.0 Custom Variant and Variant Library Synthesis for IGHG2

    Disorders / Diseases
    for IGHG2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGHG2 for disorders           About GeneDecksing

    OMIM gene information: 147110    OMIM disorders: --

    6 diseases for IGHG2:    About MalaCards
    sarcomatosis    congenital hypogammaglobulinemia    systemic lupus erythematosus    lupus erythematosus
    myopathy    myeloma

    2 diseases from the University of Copenhagen DISEASES database for IGHG2:
    Sarcomatosis     Congenital hypogammaglobulinemia
    Genatlas disease: IGHG2
    IGG2 deficiency caused by a mutated membrane-bound form of gamma 2 heavy chain,with recurrent sino-pulmonary
    infections

    Human Genome Epidemiology (HuGE) Navigator: IGHG2 (1 document)

    Export disorders for IGHG2 gene to outside databases

    Publications
    for IGHG2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGHG2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with IGHG2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (2004)
    2. Characterization of the two unique human anti-flavin monoclonal immunoglobulins. (PubMed id 7737190)1, 2 Stoppini M.... Ferri G. (1995)
    3. Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. (PubMed id 6804948)1, 2 Ellison J.W. and Hood L.E. (1982)
    4. Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes. (PubMed id 6329676)1, 2 Krawinkel U. and Rabbitts T.H. (1982)
    5. Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. (PubMed id 6811139)1, 2 Takahashi N.... Honjo T. (1982)
    6. The primary structure of a human IgG2 heavy chain: genetic, evolutionary, and functional implications. (PubMed id 6774012)1, 2 Wang A.-C.... Fudenberg H.H. (1980)
    7. The amino acid sequences of the three heavy chain constant region domains of a human IgG2 myeloma protein. (PubMed id 113060)1, 2 Connell G.E.... Hofmann T. (1979)
    8. A note of the amino acid sequence of residues 381-391 of human immunoglobulins gamma chains. (PubMed id 118920)1, 2 Hofmann T. and Parr D.M. (1979)
    9. Disulphide bridges of the heavy chain of human immunoglobulin G2. (PubMed id 4940472)1, 2 Milstein C. and Frangione B. (1971)
    10. Structural studies of immunoglobulin G. (PubMed id 5782707)1, 2 Frangione B.... Pink J.R.L. (1969)

    External Searches for IGHG2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IGHG2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3501 HGNC: 5526 AceView: IGHG2andIGHGP Ensembl:ENSG00000211893 euGenes: HUgn3501
    ECgene: IGHG2 H-InvDB: IGHG2

    Other Databases showing IGHG2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IGHG2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGHG2 Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGHG2 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IGHG2basehttp://bioinf.uta.fi/IGHG2base/
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHG2&species=Homo+sapiens

    Intellectual Property
    for IGHG2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGHG2 gene:
    Search GeneIP for patents involving IGHG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IGHG2 gene

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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGHG2
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     GenScript Custom Purified and Recombinant Proteins Services for IGHG2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for IGHG2
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     Novus Tissue Slides
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     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for IGHG2
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     Search ThermoFisher Antibodies for IGHG2
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