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Aliases for IGHG1 Gene

Aliases for IGHG1 Gene

  • Immunoglobulin Heavy Constant Gamma 1 (G1m Marker) 2 3

External Ids for IGHG1 Gene

Previous GeneCards Identifiers for IGHG1 Gene

  • GC14M103243
  • GC14U900161
  • GC14M104063
  • GC14M104065
  • GC14M105244
  • GC14M105278
  • GC14M105275
  • GC14M106204
  • GC14M086340

Summaries for IGHG1 Gene

GeneCards Summary for IGHG1 Gene

IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)) is a Protein Coding gene. Diseases associated with IGHG1 include heavy chain deposition disease and chronic lymphocytic leukemia. Among its related pathways are Immune System and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

Gene Wiki entry for IGHG1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHG1 Gene

Genomics for IGHG1 Gene

Genomic Location for IGHG1 Gene

Chromosome:
14
Start:
105,668,113 bp from pter
End:
106,538,344 bp from pter
Size:
870,232 bases
Orientation:
Minus strand

Genomic View for IGHG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for IGHG1 Gene

No data available for Regulatory Elements for IGHG1 Gene

Proteins for IGHG1 Gene

  • Protein details for IGHG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01857-IGHG1_HUMAN
    Recommended name:
    Ig gamma-1 chain C region
    Protein Accession:
    P01857

    Protein attributes for IGHG1 Gene

    Size:
    330 amino acids
    Molecular mass:
    36106 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Nie has the G1M(17) allotypic marker, 97-K, and the G1M(1) markers, 239-D and 241-L. KOL and EU sequences have the G1M(3) marker and the G1M (non-1) markers
    SequenceCaution:
    • Sequence=AAC82527.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHG1 Gene

neXtProt entry for IGHG1 Gene

Proteomics data for IGHG1 Gene at MOPED

Post-translational modifications for IGHG1 Gene

  • Glycosylation at Asn 180
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IGHG1 Gene

Domains & Families for IGHG1 Gene

Gene Families for IGHG1 Gene

Protein Domains for IGHG1 Gene

Suggested Antigen Peptide Sequences for IGHG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHG1: view

No data available for UniProtKB/Swiss-Prot for IGHG1 Gene

Function for IGHG1 Gene

Molecular function for IGHG1 Gene

GENATLAS Biochemistry:
immunoglobulin,gamma 1 (Gm marker)

Gene Ontology (GO) - Molecular Function for IGHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 6287432
GO:0005515 protein binding IPI 11567028
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGHG1: view
genes like me logo Genes that share phenotypes with IGHG1: view

Animal Models for IGHG1 Gene

MGI Knock Outs for IGHG1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for IGHG1 Gene

Localization for IGHG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG1 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for IGHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IGHG1: view

No data available for Subcellular locations from COMPARTMENTS for IGHG1 Gene

Pathways & Interactions for IGHG1 Gene

genes like me logo Genes that share pathways with IGHG1: view

Gene Ontology (GO) - Biological Process for IGHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IBA --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGHG1: view

No data available for SIGNOR curated interactions for IGHG1 Gene

Drugs & Compounds for IGHG1 Gene

(24) Drugs for IGHG1 Gene - From: DGIdb and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL Experimental Pharma Target 0
(2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE Experimental Pharma Target 0
[2'-CARBOXYLETHYL]-10-METHYL-ANTHRACENE ENDOPEROXIDE Experimental Pharma Target 0
2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID Experimental Pharma Target 0
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGHG1: view

Transcripts for IGHG1 Gene

Unigene Clusters for IGHG1 Gene

Immunoglobulin heavy constant gamma 1 (G1m marker):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG1 Gene

No ASD Table

Relevant External Links for IGHG1 Gene

GeneLoc Exon Structure for
IGHG1
ECgene alternative splicing isoforms for
IGHG1

Expression for IGHG1 Gene

mRNA expression in normal human tissues for IGHG1 Gene

mRNA differential expression in normal tissues according to GTEx for IGHG1 Gene

This gene is overexpressed in Spleen (x26.3).

Protein differential expression in normal tissues from HIPED for IGHG1 Gene

This gene is overexpressed in Vitreous humor (11.4) and Cerebrospinal fluid (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHG1 Gene



SOURCE GeneReport for Unigene cluster for IGHG1 Gene Hs.510635

genes like me logo Genes that share expression patterns with IGHG1: view

Protein tissue co-expression partners for IGHG1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHG1 Gene

Orthologs for IGHG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ighg1 16
Ighg1 36
  • 63 (a)
ManyToMany
Ighg2b 36
  • 58 (a)
ManyToMany
Ighg2c 36
  • 65 (a)
ManyToMany
Ighg3 36
  • 62 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 36
  • 15 (a)
OneToMany
Species with no ortholog for IGHG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHG1 Gene

ENSEMBL:
Gene Tree for IGHG1 (if available)
TreeFam:
Gene Tree for IGHG1 (if available)

Paralogs for IGHG1 Gene

Paralogs for IGHG1 Gene

Pseudogenes.org Pseudogenes for IGHG1 Gene

genes like me logo Genes that share paralogs with IGHG1: view

Variants for IGHG1 Gene

Sequence variations from dbSNP and Humsavar for IGHG1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_003886 -
VAR_003887 -
VAR_003888 -

Relevant External Links for IGHG1 Gene

HapMap Linkage Disequilibrium report
IGHG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHG1 Gene

Disorders for IGHG1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IGHG1 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
heavy chain deposition disease
  • hcdd
chronic lymphocytic leukemia
  • lymphoplasmacytic leukemia
multiple myeloma
  • plasma cell myeloma
- elite association
Search IGHG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IGHG1_HUMAN
  • Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. {ECO:0000269 PubMed:11972529, ECO:0000269 PubMed:8943038}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

Genatlas disease for IGHG1 Gene

infections,recurrent

Relevant External Links for IGHG1

Genetic Association Database (GAD)
IGHG1
Human Genome Epidemiology (HuGE) Navigator
IGHG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGHG1
genes like me logo Genes that share disorders with IGHG1: view

Publications for IGHG1 Gene

  1. IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab. (PMID: 19319024) Magdelaine-Beuzelin C. … Watier H. (Pharmacogenet. Genomics 2009) 23 67
  2. Quantitation of soluble aggregates in recombinant monoclonal antibody cell culture by pH-gradient protein A chromatography. (PMID: 19268420) Pan H. … Huang G. (Anal. Biochem. 2009) 23 67
  3. An immunoglobulin fusion protein based on the gp120-CD4 receptor complex potently inhibits human immunodeficiency virus type 1 in vitro. (PMID: 16796521) Vu J.R. … DeVico A. (AIDS Res. Hum. Retroviruses 2006) 23 67
  4. "Top Down" characterization is a complementary technique to peptide sequencing for identifying protein species in complex mixtures. (PMID: 14582646) Nemeth-Cawley J.F. … Rouse J.C. (J. Proteome Res. 2003) 23 67
  5. Down regulation of B cells by immunization with a fusion protein of a self CD20 peptide and a foreign IgG.Fc fragment. (PMID: 11841845) Huang J. … Chang T.W. (Immunol. Lett. 2002) 23 67

Products for IGHG1 Gene

Sources for IGHG1 Gene

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