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IGHG1 Gene

protein-coding   GIFtS: 55
GCID: GC14M106204

Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)

  See IGHG1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)1 2

External Ids:    HGNC: 55251   Entrez Gene: 35002   Ensembl: ENSG000002118967   OMIM: 1471005   UniProtKB: P018573   

Export aliases for IGHG1 gene to outside databases

Previous GC identifers: GC14M103243 GC14U900161 GC14M104063 GC14M104065 GC14M105244 GC14M105278 GC14M105275 GC14M086340


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGHG1 Gene:
IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)) is a protein-coding gene. Diseases associated with IGHG1 include congenital hypogammaglobulinemia, and b-cell chronic lymphocytic leukemia. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.

Gene Wiki entry for IGHG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  NT_187600.1  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IGHG1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IGHG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGHG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHG1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106204:  view genomic region     (about GC identifiers)

Start:
106,202,680 bp from pter      End:
106,209,408 bp from pter
Size:
6,729 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IGHG1_HUMAN, P01857 (See protein sequence)
Recommended Name: Ig gamma-1 chain C region  
Size: 330 amino acids; 36106 Da
Miscellaneous: Nie has the G1M(17) allotypic marker, 97-K, and the G1M(1) markers, 239-D and 241-L. KOL and EU
sequences have the G1M(3) marker and the G1M (non-1) markers
Sequence caution: Sequence=AAC82527.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for IGHG1 (see all 112):
1AJ7 (3D)        1AQK (3D)        1BEY (3D)        1D5B (3D)        1D5I (3D)        1D6V (3D)    

Explore the universe of human proteins at neXtProt for IGHG1: NX_P01857

Explore proteomics data for IGHG1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn180
  • Modification sites at PhosphoSitePlus

  • See IGHG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000374990   ENSP00000374991   ENSP00000374984  
    Reactome Protein details: P01857

    IGHG1 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for IGHG1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGH: Immunoglobulins / IGH locus

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01857

    ProtoNet protein and cluster: P01857

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type


    Find genes that share domains with IGHG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for IGHG1:
    immunoglobulin,gamma 1 (Gm marker)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS6287432
    GO:0005515protein binding IPI11567028
         
    Find genes that share ontologies with IGHG1           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Ighg1):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  no phenotypic analysis 
     tumorigenesis 

    Find genes that share phenotypes with IGHG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IGHG1: Ighg1tm1Ksho Ighg1tm3Cgn Ighg1tm2Cgn Ighg1tm1.1Ksho Ighg1tm4Cgn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGHG1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGHG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGHG1

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGHG1_HUMAN, P01857: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    peroxisome2
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0016020membrane ----
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with IGHG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGHG1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Creation of C4 and C2 activators
    Creation of C4 and C2 activators0.85
    Complement cascade0.68
    Initial triggering of complement0.85
    FCGR activation0.54
    Classical antibody-mediated complement activation0.82
    Role of phospholipids in phagocytosis0.53
    2Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    3Complement Pathway
    Immune response Classic complement pathway0.56
    4Development IGF 1 receptor signaling
    Immune response IL 4 signaling pathway0.39
    5Immune response Role of DAP12 receptors in NK cells
    Immune response CD16 signaling in NK cells0.33


    Find genes that share SuperPaths with IGHG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for IGHG1
        Immune response IL-4 signaling pathway
    Immune response CD16 signaling in NK cells
    Immune response Classical complement pathway

    1 BioSystems Pathway for IGHG1
        IL4-mediated signaling events

    5 Reactome Pathways for IGHG1
        Classical antibody-mediated complement activation
    Regulation of actin dynamics for phagocytic cup formation
    FCGR activation
    Role of phospholipids in phagocytosis
    Initial triggering of complement


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGHG1
    Interactions:

        Search GeneGlobe Interaction Network for IGHG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IGHG1 (P018571, 2, 3 ENSP000003749904) via UniProtKB, MINT, STRING, and/or I2D (see all 141)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCGR2BP319941, 3, ENSP000003514974EBI-356114,EBI-724784 I2D: score=1 STRING: ENSP00000351497
    IKBKGQ9Y6K92, 3MINT-48194 I2D: score=2 
    IGKCP018342, 3, ENSP000003747774MINT-24896 MINT-25051 I2D: score=3 STRING: ENSP00000374777
    TRAF1Q130772, 3, ENSP000003629944MINT-49522 I2D: score=2 STRING: ENSP00000362994
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ----
    GO:0006956complement activation TAS--
    GO:0006958complement activation, classical pathway TAS--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with IGHG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for IGHG1

    Selected DrugBank Compounds for IGHG1 (see all 25)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL-- --target--10592235
    (2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE-- --target--10592235
    2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID-- --target--10592235
    3-(10-METHYL-ANTHRACEN-9-YL)-PROPIONIC ACID-- --target--10592235
    3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID-- --target--10592235
    4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID-- --target--10592235
    4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE-- --target--10592235
    5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID-- --target--10592235
    5-BETA-ANDROSTANE-3,17-DIONE-- --target--10592235
    6-{4-[HYDROXY-(4-NITRO-PHENOXY)-PHOSPHORYL]-BUTYRYLAMINO}-HEXANOIC ACID-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    Unigene Cluster for IGHG1:

    Immunoglobulin heavy constant gamma 1 (G1m marker)
    Hs.510635  [show with all ESTs]
    Unigene Representative Sequence: AK090461
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000390548(uc001yse.3) ENST00000390549 ENST00000390542
    miRNA
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    Additional mRNA sequence: 

    AB004303.1 AB006837.1 AB006839.1 AB006840.1 AB012909.1 AB022650.1 AB022652.1 AB022655.1 
    AB027433.1 AB027435.2 AB027437.2 AB027439.1 AB027441.1 AB027443.1 AB027445.1 AB027447.1 
    AB027766.1 AB030639.1 AB063667.1 AB063677.1 AB063678.1 AB063679.1 AB063680.1 AB063686.1 
    AB063687.1 AB063697.1 AB063703.1 AB063706.1 AB063719.1 AB063724.1 AB063750.1 AB063756.1 
    AB063801.1 AB063809.1 AB063849.1 AB063864.1 AB063872.1 AB063881.1 AB063891.1 AB063907.1 
    AB063912.1 AB063922.1 AB066898.1 AB066901.1 AB066908.1 AB066925.1 AB066926.1 AB066932.1 
    AB066940.1 AB066944.1 AB066945.1 AB066947.1 AB066951.1 AB066952.1 AB066955.1 AB066956.1 
    AB066959.1 AB066965.1 AB066970.1 AB066990.1 AB066996.1 AB067004.1 AB067014.1 AB067020.1 
    AB067047.1 AB067048.1 AB067054.1 AB067059.1 AB067072.1 AB067107.1 AB067119.1 AB067126.1 
    AB067141.1 AB067168.1 AB067172.1 AB067173.1 AB067178.1 AB067181.1 AB067192.1 AB067247.1 
    AB067256.1 AB067267.1 AB067281.1 AB067287.1 AB067291.1 AB067301.1 AB067307.1 AB067308.1 
    AB067314.1 AB067316.1 AB067319.1 AB067335.1 AB067336.1 AB067338.1 AB067339.1 AB067340.1 
    AB067341.1 AB067342.1 AB067343.1 AB067344.1 AB067347.1 AB067349.1 AB067351.1 AB067353.1 
    AB067354.1 AB067355.1 AB067357.1 AB067358.1 AB067361.1 AB067362.1 AB067363.1 AB067364.1 
    AB067365.1 AB067366.1 AB067368.1 AB067369.1 AB067370.1 AB067373.1 AB067374.1 AB067375.1 
    AB067376.1 AB067385.1 AB067386.1 AB067390.1 AB067393.1 AB067394.1 AB084083.1 AB084084.1 
    AB087877.1 AB095272.1 AB095276.1 AB110646.1 AB159728.1 AB245095.1 AB266513.1 AB274406.1 
    AB274408.1 AB274410.1 AB274412.1 AB288084.1 AB289325.1 AB289326.1 AB289327.1 AB363079.1 
    AB363083.1 AB363106.1 AB363142.1 AB363143.1 AB363146.1 AB363155.1 AB363161.1 AB363196.1 
    AB363237.1 AB373612.1 AB373613.1 AB373634.1 AB374357.1 AB453230.1 AB453231.1 AB453232.1 
    AB453233.1 AB585999.1 AB608263.1 AB608264.1 AB608265.1 AF001789.1 AF006517.1 AF006518.1 
    AF006521.1 AF006523.1 AF006526.1 AF006527.1 AF006528.1 AF013615.1 AF013616.1 AF013619.1 
    AF013620.1 AF013621.1 AF013622.1 AF015135.1 AF015136.1 AF015137.1 AF015138.1 AF015139.1 
    AF015140.1 AF015141.1 AF015142.1 AF015144.1 AF015146.1 AF017457.1 AF019639.1 AF019640.1 
    AF019641.1 AF019642.1 AF021940.1 AF021941.1 AF021947.1 AF021969.1 AF021978.1 AF021980.1 
    AF021985.1 AF021987.1 AF021988.1 AF021993.1 AF021994.1 AF021997.1 AF022000.1 AF022003.1 
    AF022007.1 AF027159.2 AF028092.1 AF028093.1 AF028094.1 AF028095.1 AF028096.1 AF028097.1 
    AF028098.1 AF028102.1 AF028111.1 AF028112.1 AF028114.1 AF028115.1 AF028119.1 AF028120.1 
    AF028121.1 AF032352.1 AF032358.1 AF035019.1 AF035020.1 AF035030.1 AF035039.1 AF035040.1 
    AF051100.1 AF052386.1 AF062092.1 AF062110.1 AF062114.1 AF062123.1 AF062131.1 AF062134.1 
    AF062135.1 AF062137.1 AF062139.1 AF062140.1 AF062142.1 AF062143.1 AF062151.1 AF062159.1 
    AF062165.1 AF062170.1 AF062178.1 AF062179.1 AF062194.1 AF062195.1 AF062197.1 AF062200.1 
    AF062203.1 AF062207.1 AF062213.1 AF062219.1 AF062220.1 AF062221.1 AF062226.1 AF062230.1 
    AF062245.1 AF062254.1 AF062256.1 AF062257.1 AF062258.1 AF062262.1 AF062264.1 AF062267.1 
    AF062271.1 AF062272.1 AF062273.1 AF062284.1 AF064881.1 AF064882.1 AF064883.1 AF064884.1 
    AF067121.1 AF069906.1 AF069907.1 AF078551.1 AF082193.1 AF082200.1 AF085652.1 AF085653.1 
    AF090356.1 AF098366.1 AF099198.1 AF103028.1 AF103030.1 AF103033.2 AF103035.1 AF103039.1 
    AF103050.1 AF103052.1 AF103064.1 AF103067.1 AF103070.1 AF103079.1 AF103086.1 AF103092.1 
    AF103096.1 AF103114.1 AF103117.1 AF103119.1 AF103120.1 AF103122.1 AF103124.1 AF103125.1 
    AF103129.1 AF103131.1 AF103153.1 AF103154.1 AF103160.1 AF103163.1 AF103167.1 AF103168.1 
    AF103174.2 AF103175.1 AF103177.1 AF103179.1 AF103181.1 AF103185.1 AF103186.1 AF103189.1 
    AF103190.1 AF103191.1 AF103192.1 AF103199.1 AF103203.1 AF103205.1 AF103206.1 AF103207.1 
    AF103211.1 AF103212.1 AF103219.1 AF103223.1 AF103225.1 AF103226.1 AF103231.1 AF103233.1 
    AF103237.1 AF103238.1 AF103247.1 AF103248.1 AF103253.1 AF103261.1 AF103263.1 AF103264.1 
    AF103265.1 AF103272.1 AF103281.1 AF103282.1 AF103288.1 AF103308.1 AF103311.1 AF103332.1 
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