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Aliases for IGHG1 Gene

Aliases for IGHG1 Gene

  • Immunoglobulin Heavy Constant Gamma 1 (G1m Marker) 2 3 5

External Ids for IGHG1 Gene

Previous GeneCards Identifiers for IGHG1 Gene

  • GC14M103243
  • GC14U900161
  • GC14M104063
  • GC14M104065
  • GC14M105244
  • GC14M105278
  • GC14M105275
  • GC14M106204
  • GC14M086340
  • GC14M105668

Summaries for IGHG1 Gene

GeneCards Summary for IGHG1 Gene

IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)) is a Protein Coding gene. Diseases associated with IGHG1 include Chronic Lymphocytic Leukemia and Heavy Chain Deposition Disease. Among its related pathways are Immune System and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG3.

Gene Wiki entry for IGHG1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHG1 Gene

Genomics for IGHG1 Gene

Regulatory Elements for IGHG1 Gene

Enhancers for IGHG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F105743 0.6 Ensembl ENCODE 0.8 -3.0 -3030 5.0 CTCF KLF1 INSM2 ZNF76 KLF17 ZIC2 ZEB1 CTBP1 PATZ1 PRDM10 ENSG00000253364 ENSG00000211974 IGHV3-43 GC14P105748 IGHG1
GH14F105733 0.4 ENCODE 0.4 +9.2 9225 0.3 HDGF KLF1 PKNOX1 ZNF48 CTBP1 MTA3 ZNF169 ZNF207 ZNF600 ZNF280C IGHG1 IGHEP1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGHG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHG1 Gene

Chromosome:
14
Start:
105,736,343 bp from pter
End:
105,743,071 bp from pter
Size:
6,729 bases
Orientation:
Minus strand

Genomic View for IGHG1 Gene

Genes around IGHG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG1 Gene

Proteins for IGHG1 Gene

  • Protein details for IGHG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01857-IGHG1_HUMAN
    Recommended name:
    Ig gamma-1 chain C region
    Protein Accession:
    P01857

    Protein attributes for IGHG1 Gene

    Size:
    330 amino acids
    Molecular mass:
    36106 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Nie has the G1M(17) allotypic marker, 97-K, and the G1M(1) markers, 239-D and 241-L. KOL and EU sequences have the G1M(3) marker and the G1M (non-1) markers.
    SequenceCaution:
    • Sequence=AAC82527.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHG1 Gene

neXtProt entry for IGHG1 Gene

Post-translational modifications for IGHG1 Gene

  • Glycosylation at Asn 180
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHG1 Gene

Antibody Products

  • Abcam antibodies for IGHG1
  • Santa Cruz Biotechnology (SCBT) Antibodies for IGHG1

No data available for DME Specific Peptides for IGHG1 Gene

Domains & Families for IGHG1 Gene

Gene Families for IGHG1 Gene

Protein Domains for IGHG1 Gene

Suggested Antigen Peptide Sequences for IGHG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHG1: view

No data available for UniProtKB/Swiss-Prot for IGHG1 Gene

Function for IGHG1 Gene

Molecular function for IGHG1 Gene

GENATLAS Biochemistry:
immunoglobulin,gamma 1 (Gm marker)

Gene Ontology (GO) - Molecular Function for IGHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 6287432
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 11567028
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGHG1: view

Human Phenotype Ontology for IGHG1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHG1 Gene

Localization for IGHG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG1 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for IGHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 16502470
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGHG1: view

No data available for Subcellular locations from COMPARTMENTS for IGHG1 Gene

Pathways & Interactions for IGHG1 Gene

genes like me logo Genes that share pathways with IGHG1: view

Interacting Proteins for IGHG1 Gene

Selected Interacting proteins: P01857-IGHG1_HUMAN for IGHG1 Gene via MINT UniProtKB IID

Symbol External ID(s) Details
HLA-B
HLA-DRB1
HLA-A
IGKC
FCGR2B

Gene Ontology (GO) - Biological Process for IGHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway IBA,TAS --
genes like me logo Genes that share ontologies with IGHG1: view

No data available for SIGNOR curated interactions for IGHG1 Gene

Drugs & Compounds for IGHG1 Gene

(24) Drugs for IGHG1 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL Experimental Pharma Target 0
(2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE Experimental Pharma Target 0
[2'-CARBOXYLETHYL]-10-METHYL-ANTHRACENE ENDOPEROXIDE Experimental Pharma Target 0
2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID Experimental Pharma Target 0
3-(10-METHYL-ANTHRACEN-9-YL)-PROPIONIC ACID Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGHG1: view

Transcripts for IGHG1 Gene

Unigene Clusters for IGHG1 Gene

Immunoglobulin heavy constant gamma 1 (G1m marker):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG1 Gene

No ASD Table

Relevant External Links for IGHG1 Gene

GeneLoc Exon Structure for
IGHG1
ECgene alternative splicing isoforms for
IGHG1

Expression for IGHG1 Gene

mRNA expression in normal human tissues for IGHG1 Gene

mRNA differential expression in normal tissues according to GTEx for IGHG1 Gene

This gene is overexpressed in Spleen (x26.3).

Protein differential expression in normal tissues from HIPED for IGHG1 Gene

This gene is overexpressed in Vitreous humor (11.4) and Cerebrospinal fluid (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHG1 Gene



Protein tissue co-expression partners for IGHG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGHG1 Gene:

IGHG1

SOURCE GeneReport for Unigene cluster for IGHG1 Gene:

Hs.510635
genes like me logo Genes that share expression patterns with IGHG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHG1 Gene

Orthologs for IGHG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 72 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ighg2c 35
  • 65 (a)
ManyToMany
Ighg1 35
  • 63 (a)
ManyToMany
Ighg3 35
  • 62 (a)
ManyToMany
Ighg2b 35
  • 58 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 43 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 35
  • 15 (a)
OneToMany
Species where no ortholog for IGHG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHG1 Gene

ENSEMBL:
Gene Tree for IGHG1 (if available)
TreeFam:
Gene Tree for IGHG1 (if available)

Paralogs for IGHG1 Gene

Variants for IGHG1 Gene

Sequence variations from dbSNP and Humsavar for IGHG1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_003886 --
VAR_003887 --
VAR_003888 --

Relevant External Links for IGHG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHG1 Gene

Disorders for IGHG1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IGHG1 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
heavy chain deposition disease
  • hcdd
multiple myeloma
  • myeloma, multiple amyloidosis, systemic, included
- elite association - COSMIC cancer census association via MalaCards
Search IGHG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IGHG1_HUMAN
  • Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. {ECO:0000269 PubMed:11972529, ECO:0000269 PubMed:8943038}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

Genatlas disease for IGHG1 Gene

infections,recurrent

Relevant External Links for IGHG1

Genetic Association Database (GAD)
IGHG1
Human Genome Epidemiology (HuGE) Navigator
IGHG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGHG1
genes like me logo Genes that share disorders with IGHG1: view

Publications for IGHG1 Gene

  1. IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab. (PMID: 19319024) Magdelaine-Beuzelin C. … Watier H. (Pharmacogenet. Genomics 2009) 3 22 46 64
  2. Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura. (PMID: 19317746) Satoh T. … Kuwana M. (Tissue Antigens 2009) 3 46 64
  3. Association between Gm allotypes and asthma severity from childhood to young middle age. (PMID: 17933503) Gustafsson P.M. … Kjellman B. (Respir Med 2008) 3 46 64
  4. Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies. (PMID: 18821675) O'Hanlon T.P. … Miller F.W. (Arthritis Rheum. 2008) 3 46 64
  5. Immunoglobulin enhancer HS1,2 polymorphism: a new powerful anthropogenetic marker. (PMID: 17044868) Giambra V. … Frezza D. (Ann. Hum. Genet. 2006) 3 46 64

Products for IGHG1 Gene

Sources for IGHG1 Gene

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