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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHG1 Gene

protein-coding   GIFtS: 54
GCID: GC14M106204

Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)1 2

External Ids:    HGNC: 55251   Entrez Gene: 35002   Ensembl: ENSG000002118967   OMIM: 1471005   UniProtKB: P018573   

Export aliases for IGHG1 gene to outside databases

Previous GC identifers: GC14M103243 GC14U900161 GC14M104063 GC14M104065 GC14M105244 GC14M105278 GC14M105275 GC14M086340


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGHG1 Gene: 
IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)) is a protein-coding gene. Diseases associated with IGHG1 include congenital hypogammaglobulinemia, and plasma cell leukemia, and among its related super-pathways are Immune response Lectin induced complement pathway and Classical antibody-mediated complement activation. GO annotations related to this gene include antigen binding and protein binding. An important paralog of this gene is IGHG2.

Gene Wiki entry for IGHG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHG1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHG1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106204:  view genomic region     (about GC identifiers)

Start:
106,202,680 bp from pter      End:
106,209,408 bp from pter
Size:
6,729 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IGHG1_HUMAN, P01857 (See protein sequence)
Recommended Name: Ig gamma-1 chain C region  
Size: 330 amino acids; 36106 Da
Subcellular location: Secreted
Miscellaneous: Nie has the G1M(17) allotypic marker, 97-K, and the G1M(1) markers, 239-D and 241-L. KOL and EU
sequences have the G1M(3) marker and the G1M (non-1) markers
Sequence caution: Sequence=AAC82527.1; Type=Erroneous initiation;
6/96 PDB 3D structures from and Proteopedia for IGHG1 (see all 96):
1AJ7 (3D)        1AQK (3D)        1BEY (3D)        1D5B (3D)        1D5I (3D)        1D6V (3D)    

Explore the universe of human proteins at neXtProt for IGHG1: NX_P01857

Explore proteomics data for IGHG1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01857

  • IGHG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGHG1 Protein Expression

    ENSEMBL proteins: 
     ENSP00000374990   ENSP00000374991   ENSP00000374984  
    Reactome Protein details: P01857
    Human Recombinant Protein Products for IGHG1: 
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    Novus Biologicals IGHG1 Protein
    Novus Biologicals IGHG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0016020membrane NAS--

    IGHG1 for ontologies           About GeneDecksing



    IGHG1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for IGHG1 

    Assay Products for IGHG1: 
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    GenScript Custom Assay Services for IGHG1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGH: Immunoglobulins / IGH locus

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01857

    ProtoNet protein and cluster: P01857

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type


    IGHG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for IGHG1:
    immunoglobulin,gamma 1 (Gm marker)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS6287432
    GO:0005515protein binding IPI11567028
         
    IGHG1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Ighg1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis  tumorigenesis 

    IGHG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IGHG1: Ighg1tm1Ksho Ighg1tm3Cgn Ighg1tm2Cgn Ighg1tm1.1Ksho Ighg1tm4Cgn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGHG1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGHG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGHG1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGHG1 

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    In Situ Assay
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGHG1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Classic complement pathway0.53
    Immune response Classical complement pathway0.52
    2Classical antibody-mediated complement activation
    Classical antibody-mediated complement activation0.88
    Complement cascade0.76
    Creation of C4 and C2 activators0.88
    FCGR activation0.70
    Initial triggering of complement0.86
    Role of phospholipids in phagocytosis0.65
    3Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.80
    Fcgamma receptor (FCGR) dependent phagocytosis0.80
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    5Immune response Fc epsilon RI pathway
    Immune response IL-4 signaling pathway0.38
    Immune response CD16 signaling in NK cells0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for IGHG1
        Immune response Classic complement pathway
    Immune response CD16 signaling in NK cells
    Immune response IL-4 signaling pathway


    3 GeneGo (Thomson Reuters) Pathways for IGHG1
        Immune response IL-4 signaling pathway
    Immune response CD16 signaling in NK cells
    Immune response Classical complement pathway

    1 BioSystems Pathway for IGHG1
        IL4-mediated signaling events

    5/10        Reactome Pathways for IGHG1 (see all 10)
        FCGR activation
    Fcgamma receptor (FCGR) dependent phagocytosis
    Classical antibody-mediated complement activation
    Regulation of actin dynamics for phagocytic cup formation
    Creation of C4 and C2 activators



    IGHG1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/120 Interacting proteins for IGHG1 (P018571, 2, 3 ENSP000003749904) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCGR2BP319941, 3, ENSP000003514974EBI-356114,EBI-724784 I2D: score=1 STRING: ENSP00000351497
    IKBKGQ9Y6K92, 3MINT-48194 I2D: score=2 
    IGKCP018342, 3, ENSP000003747774MINT-24896 MINT-25051 I2D: score=3 STRING: ENSP00000374777
    TRAF1Q130772, 3, ENSP000003629944MINT-49522 I2D: score=2 STRING: ENSP00000362994
    IGLC1P0CG043, ENSP000003748554I2D: score=2 STRING: ENSP00000374855
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS--
    GO:0006956complement activation TAS--
    GO:0006958complement activation, classical pathway TAS--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    IGHG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGHG1

    10/25 DrugBank Compounds for IGHG1 (see all 25)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL-- --target--10592235
    (2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE-- --target--10592235
    2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID-- --target--10592235
    3-(10-METHYL-ANTHRACEN-9-YL)-PROPIONIC ACID-- --target--10592235
    3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID-- --target--10592235
    4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID-- --target--10592235
    4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE-- --target--10592235
    5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID-- --target--10592235
    5-BETA-ANDROSTANE-3,17-DIONE-- --target--10592235
    6-{4-[HYDROXY-(4-NITRO-PHENOXY)-PHOSPHORYL]-BUTYRYLAMINO}-HEXANOIC ACID-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about IGHG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    Unigene Cluster for IGHG1:

    Immunoglobulin heavy constant gamma 1 (G1m marker)
    Hs.510635  [show with all ESTs]
    Unigene Representative Sequence: AK090461
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000390548(uc001yse.3) ENST00000390549 ENST00000390542

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene RNAi
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGHG1
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    Additional mRNA sequence: 

    AB004303.1 AB006837.1 AB006839.1 AB006840.1 AB012909.1 AB022650.1 AB022652.1 AB022655.1 
    AB027433.1 AB027435.2 AB027437.2 AB027439.1 AB027441.1 AB027443.1 AB027445.1 AB027447.1 
    AB027766.1 AB030639.1 AB063667.1 AB063677.1 AB063678.1 AB063679.1 AB063680.1 AB063686.1 
    AB063687.1 AB063697.1 AB063703.1 AB063706.1 AB063719.1 AB063724.1 AB063750.1 AB063756.1 
    AB063801.1 AB063809.1 AB063849.1 AB063864.1 AB063872.1 AB063881.1 AB063891.1 AB063907.1 
    AB063912.1 AB063922.1 AB066898.1 AB066901.1 AB066908.1 AB066925.1 AB066926.1 AB066932.1 
    AB066940.1 AB066944.1 AB066945.1 AB066947.1 AB066951.1 AB066952.1 AB066955.1 AB066956.1 
    AB066959.1 AB066965.1 AB066970.1 AB066990.1 AB066996.1 AB067004.1 AB067014.1 AB067020.1 
    AB067047.1 AB067048.1 AB067054.1 AB067059.1 AB067072.1 AB067107.1 AB067119.1 AB067126.1 
    AB067141.1 AB067168.1 AB067172.1 AB067173.1 AB067178.1 AB067181.1 AB067192.1 AB067247.1 
    AB067256.1 AB067267.1 AB067281.1 AB067287.1 AB067291.1 AB067301.1 AB067307.1 AB067308.1 
    AB067314.1 AB067316.1 AB067319.1 AB067335.1 AB067336.1 AB067338.1 AB067339.1 AB067340.1 
    AB067341.1 AB067342.1 AB067343.1 AB067344.1 AB067347.1 AB067349.1 AB067351.1 AB067353.1 
    AB067354.1 AB067355.1 AB067357.1 AB067358.1 AB067361.1 AB067362.1 AB067363.1 AB067364.1 
    AB067365.1 AB067366.1 AB067368.1 AB067369.1 AB067370.1 AB067373.1 AB067374.1 AB067375.1 
    AB067376.1 AB067385.1 AB067386.1 AB067390.1 AB067393.1 AB067394.1 AB084083.1 AB084084.1 
    AB087877.1 AB095272.1 AB095276.1 AB110646.1 AB159728.1 AB245095.1 AB266513.1 AB274406.1 
    AB274408.1 AB274410.1 AB274412.1 AB288084.1 AB289325.1 AB289326.1 AB289327.1 AB363079.1 
    AB363083.1 AB363106.1 AB363142.1 AB363143.1 AB363146.1 AB363155.1 AB363161.1 AB363196.1 
    AB363237.1 AB373612.1 AB373613.1 AB373634.1 AB374357.1 AB453230.1 AB453231.1 AB453232.1 
    AB453233.1 AB585999.1 AB608263.1 AB608264.1 AB608265.1 AF001789.1 AF006517.1 AF006518.1 
    AF006521.1 AF006523.1 AF006526.1 AF006527.1 AF006528.1 AF013615.1 AF013616.1 AF013619.1 
    AF013620.1 AF013621.1 AF013622.1 AF015135.1 AF015136.1 AF015137.1 AF015138.1 AF015139.1 
    AF015140.1 AF015141.1 AF015142.1 AF015144.1 AF015146.1 AF017457.1 AF019639.1 AF019640.1 
    AF019641.1 AF019642.1 AF021940.1 AF021941.1 AF021947.1 AF021969.1 AF021978.1 AF021980.1 
    AF021985.1 AF021987.1 AF021988.1 AF021993.1 AF021994.1 AF021997.1 AF022000.1 AF022003.1 
    AF022007.1 AF027159.2 AF028092.1 AF028093.1 AF028094.1 AF028095.1 AF028096.1 AF028097.1 
    AF028098.1 AF028102.1 AF028111.1 AF028112.1 AF028114.1 AF028115.1 AF028119.1 AF028120.1 
    AF028121.1 AF032352.1 AF032358.1 AF035019.1 AF035020.1 AF035030.1 AF035039.1 AF035040.1 
    AF051100.1 AF052386.1 AF062092.1 AF062110.1 AF062114.1 AF062123.1 AF062131.1 AF062134.1 
    AF062135.1 AF062137.1 AF062139.1 AF062140.1 AF062142.1 AF062143.1 AF062151.1 AF062159.1 
    AF062165.1 AF062170.1 AF062178.1 AF062179.1 AF062194.1 AF062195.1 AF062197.1 AF062200.1 
    AF062203.1 AF062207.1 AF062213.1 AF062219.1 AF062220.1 AF062221.1 AF062226.1 AF062230.1 
    AF062245.1 AF062254.1 AF062256.1 AF062257.1 AF062258.1 AF062262.1 AF062264.1 AF062267.1 
    AF062271.1 AF062272.1 AF062273.1 AF062284.1 AF064881.1 AF064882.1 AF064883.1 AF064884.1 
    AF067121.1 AF069906.1 AF069907.1 AF078551.1 AF082193.1 AF082200.1 AF085652.1 AF085653.1 
    AF090356.1 AF098366.1 AF099198.1 AF103028.1 AF103030.1 AF103033.2 AF103035.1 AF103039.1 
    AF103050.1 AF103052.1 AF103064.1 AF103067.1 AF103070.1 AF103079.1 AF103086.1 AF103092.1 
    AF103096.1 AF103114.1 AF103117.1 AF103119.1 AF103120.1 AF103122.1 AF103124.1 AF103125.1 
    AF103129.1 AF103131.1 AF103153.1 AF103154.1 AF103160.1 AF103163.1 AF103167.1 AF103168.1 
    AF103174.2 AF103175.1 AF103177.1 AF103179.1 AF103181.1 AF103185.1 AF103186.1 AF103189.1 
    AF103190.1 AF103191.1 AF103192.1 AF103199.1 AF103203.1 AF103205.1 AF103206.1 AF103207.1 
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    S65761.1 S67077.1 S67981.1 S71250.1 S73138.1 S74498.1 S74500.1 S74501.1 
    S74502.1 S74639.1 S74640.1 S74642.1 S74643.1 S75894.1 S76902.1 S80750.1 
    U00514.1 U00519.1 U00526.1 U00528.1 U00529.1 U00531.1 U00533.1 U00534.1 
    U00535.1 U00542.1 U00543.1 U00544.1 U00548.1 U00551.1 U00554.1 U00558.1 
    U00562.1 U00564.1 U00565.1 U00568.1 U00587.1 U05889.1 U05890.1 U05892.1 
    U05893.1 U07985.1 U07987.1 U07988.1 U13195.1 U13196.1 U13197.1 U13198.1 
    U13199.1 U13200.1 U13201.1 U13202.1 U21250.1 U21251.1 U21263.1 U21264.1 
    U21265.1 U21271.1 U27189.1 U31936.1 U32152.1 U32153.1 U32159.1 U32268.1 
    U32271.1 U32479.1 U32480.1 U32481.1 U32483.1 U32484.1 U32486.1 U32488.1 
    U32489.1 U32491.1 U32599.1 U32610.1 U32612.1 U32951.1 U32952.1 U32961.1 
    U32962.1 U32963.1 U36535.1 U36542.1 U36543.1 U36544.1 U36545.1 U36546.1 
    U36547.1 U36548.1 U36549.1 U36550.1 U36551.1 U36552.1 U36553.1 U36554.1 
    U36555.1 U36556.1 U36557.1