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Aliases for IGHG1 Gene

Aliases for IGHG1 Gene

  • Immunoglobulin Heavy Constant Gamma 1 (G1m Marker) 2 3 5

External Ids for IGHG1 Gene

Previous GeneCards Identifiers for IGHG1 Gene

  • GC14M103243
  • GC14U900161
  • GC14M104063
  • GC14M104065
  • GC14M105244
  • GC14M105278
  • GC14M105275
  • GC14M106204
  • GC14M086340
  • GC14M105668

Summaries for IGHG1 Gene

GeneCards Summary for IGHG1 Gene

IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)) is a Protein Coding gene. Diseases associated with IGHG1 include Chronic Lymphocytic Leukemia and Heavy Chain Deposition Disease. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and IL4-mediated signaling events. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

Gene Wiki entry for IGHG1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHG1 Gene

Genomics for IGHG1 Gene

Regulatory Elements for IGHG1 Gene

Enhancers for IGHG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IGHG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHG1 Gene

105,736,343 bp from pter
105,743,071 bp from pter
6,729 bases
Minus strand

Genomic View for IGHG1 Gene

Genes around IGHG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG1 Gene

Proteins for IGHG1 Gene

  • Protein details for IGHG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ig gamma-1 chain C region
    Protein Accession:

    Protein attributes for IGHG1 Gene

    330 amino acids
    Molecular mass:
    36106 Da
    Quaternary structure:
    No Data Available
    • Nie has the G1M(17) allotypic marker, 97-K, and the G1M(1) markers, 239-D and 241-L. KOL and EU sequences have the G1M(3) marker and the G1M (non-1) markers.
    • Sequence=AAC82527.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHG1 Gene

neXtProt entry for IGHG1 Gene

Proteomics data for IGHG1 Gene at MOPED

Post-translational modifications for IGHG1 Gene

  • Glycosylation at Asn 180
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHG1 Gene

Antibody Products

  • Abcam antibodies for IgG1

No data available for DME Specific Peptides for IGHG1 Gene

Domains & Families for IGHG1 Gene

Gene Families for IGHG1 Gene

Protein Domains for IGHG1 Gene

Suggested Antigen Peptide Sequences for IGHG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHG1: view

No data available for UniProtKB/Swiss-Prot for IGHG1 Gene

Function for IGHG1 Gene

Molecular function for IGHG1 Gene

GENATLAS Biochemistry:
immunoglobulin,gamma 1 (Gm marker)

Human Phenotype Ontology for IGHG1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHG1 Gene

Localization for IGHG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG1 Gene


Gene Ontology (GO) - Cellular Components for IGHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGHG1: view

No data available for Subcellular locations from COMPARTMENTS for IGHG1 Gene

Pathways & Interactions for IGHG1 Gene

genes like me logo Genes that share pathways with IGHG1: view

Gene Ontology (GO) - Biological Process for IGHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS --
GO:0006956 complement activation TAS --
GO:0045087 innate immune response IBA,TAS --
GO:0050871 positive regulation of B cell activation IBA --
genes like me logo Genes that share ontologies with IGHG1: view

No data available for SIGNOR curated interactions for IGHG1 Gene

Drugs & Compounds for IGHG1 Gene

(24) Drugs for IGHG1 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL Experimental Pharma Target 0
(2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE Experimental Pharma Target 0
2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID Experimental Pharma Target 0
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGHG1: view

Transcripts for IGHG1 Gene

Unigene Clusters for IGHG1 Gene

Immunoglobulin heavy constant gamma 1 (G1m marker):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG1 Gene

No ASD Table

Relevant External Links for IGHG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHG1 Gene

mRNA expression in normal human tissues for IGHG1 Gene

mRNA differential expression in normal tissues according to GTEx for IGHG1 Gene

This gene is overexpressed in Spleen (x26.3).

Protein differential expression in normal tissues from HIPED for IGHG1 Gene

This gene is overexpressed in Vitreous humor (11.4) and Cerebrospinal fluid (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHG1 Gene

SOURCE GeneReport for Unigene cluster for IGHG1 Gene Hs.510635

genes like me logo Genes that share expression patterns with IGHG1: view

Protein tissue co-expression partners for IGHG1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHG1 Gene

Orthologs for IGHG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
(Mus musculus)
Mammalia Ighg1 36
  • 63 (a)
Ighg2b 36
  • 58 (a)
Ighg2c 36
  • 65 (a)
Ighg3 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
-- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
(Danio rerio)
Actinopterygii ighv1-4 36
  • 15 (a)
Species with no ortholog for IGHG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHG1 Gene

Gene Tree for IGHG1 (if available)
Gene Tree for IGHG1 (if available)

Paralogs for IGHG1 Gene

Paralogs for IGHG1 Gene Pseudogenes for IGHG1 Gene

genes like me logo Genes that share paralogs with IGHG1: view

Variants for IGHG1 Gene

Sequence variations from dbSNP and Humsavar for IGHG1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_003886 -
VAR_003887 -
VAR_003888 -

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for IGHG1 Gene

Disorders for IGHG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IGHG1 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
heavy chain deposition disease
  • hcdd
- elite association - COSMIC cancer census association via MalaCards
Search IGHG1 in MalaCards View complete list of genes associated with diseases


  • Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. {ECO:0000269 PubMed:11972529, ECO:0000269 PubMed:8943038}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

Genatlas disease for IGHG1 Gene


Relevant External Links for IGHG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGHG1: view

Publications for IGHG1 Gene

  1. IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab. (PMID: 19319024) Magdelaine-Beuzelin C. … Watier H. (Pharmacogenet. Genomics 2009) 3 23 48 67
  2. Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. (PMID: 25645918) Thaysen-Andersen M. … Packer N.H. (J. Biol. Chem. 2015) 3
  3. 3D Structural Fluctuation of IgG1 Antibody Revealed by Individual Particle Electron Tomography. (PMID: 25940394) Zhang X. … Ren G. (Sci Rep 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for IGHG1 Gene

Sources for IGHG1 Gene