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Aliases for IGHG1 Gene

Aliases for IGHG1 Gene

  • Immunoglobulin Heavy Constant Gamma 1 (G1m Marker) 2 3

External Ids for IGHG1 Gene

Previous GeneCards Identifiers for IGHG1 Gene

  • GC14M103243
  • GC14U900161
  • GC14M104063
  • GC14M104065
  • GC14M105244
  • GC14M105278
  • GC14M105275
  • GC14M106204
  • GC14M086340

Summaries for IGHG1 Gene

GeneCards Summary for IGHG1 Gene

IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)) is a Protein Coding gene. Diseases associated with IGHG1 include chronic lymphocytic leukemia and congenital hypogammaglobulinemia. Among its related pathways are Creation of C4 and C2 activators and Fcgamma receptor (FCGR) dependent phagocytosis. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

Gene Wiki entry for IGHG1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHG1 Gene

Genomics for IGHG1 Gene

Genomic Location for IGHG1 Gene

Start:
105,668,113 bp from pter
End:
106,538,344 bp from pter
Size:
870,232 bases
Orientation:
Minus strand

Genomic View for IGHG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGHG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG1 Gene

No data available for Regulatory Elements for IGHG1 Gene

Proteins for IGHG1 Gene

  • Protein details for IGHG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01857-IGHG1_HUMAN
    Recommended name:
    Ig gamma-1 chain C region
    Protein Accession:
    P01857
    Secondary Accessions:

    Protein attributes for IGHG1 Gene

    Size:
    330 amino acids
    Molecular mass:
    36106 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Nie has the G1M(17) allotypic marker, 97-K, and the G1M(1) markers, 239-D and 241-L. KOL and EU sequences have the G1M(3) marker and the G1M (non-1) markers
    SequenceCaution:
    • Sequence=AAC82527.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHG1 Gene

neXtProt entry for IGHG1 Gene

Proteomics data for IGHG1 Gene at MOPED

Post-translational modifications for IGHG1 Gene

  • Glycosylation at Asn180
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHG1 Gene

No data available for DME Specific Peptides for IGHG1 Gene

Domains for IGHG1 Gene

Gene Families for IGHG1 Gene

HGNC:
  • IGH :Immunoglobulins / IGH locus

Protein Domains for IGHG1 Gene

Suggested Antigen Peptide Sequences for IGHG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHG1: view

No data available for UniProtKB/Swiss-Prot for IGHG1 Gene

Function for IGHG1 Gene

Molecular function for IGHG1 Gene

GENATLAS Biochemistry: immunoglobulin,gamma 1 (Gm marker)

Gene Ontology (GO) - Molecular Function for IGHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 6287432
GO:0005515 protein binding IPI 11567028
genes like me logo Genes that share ontologies with IGHG1: view
genes like me logo Genes that share phenotypes with IGHG1: view

Animal Models for IGHG1 Gene

MGI Knock Outs for IGHG1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IGHG1 Gene

Localization for IGHG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGHG1 Gene COMPARTMENTS Subcellular localization image for IGHG1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
peroxisome 2
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IGHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGHG1: view

Pathways for IGHG1 Gene

genes like me logo Genes that share pathways with IGHG1: view

Gene Ontology (GO) - Biological Process for IGHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with IGHG1: view

Transcripts for IGHG1 Gene

Unigene Clusters for IGHG1 Gene

Immunoglobulin heavy constant gamma 1 (G1m marker):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG1 Gene

No ASD Table

Relevant External Links for IGHG1 Gene

GeneLoc Exon Structure for
IGHG1
ECgene alternative splicing isoforms for
IGHG1

Expression for IGHG1 Gene

mRNA expression in normal human tissues for IGHG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGHG1 Gene

This gene is overexpressed in Spleen (26.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGHG1 Gene

SOURCE GeneReport for Unigene cluster for IGHG1 Gene Hs.510635

genes like me logo Genes that share expressions with IGHG1: view

No data available for mRNA Expression by UniProt/SwissProt for IGHG1 Gene

Orthologs for IGHG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ighg1 16
Ighg1 36
  • 63 (a)
ManyToMany
Ighg2b 36
  • 58 (a)
ManyToMany
Ighg2c 36
  • 65 (a)
ManyToMany
Ighg3 36
  • 62 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 36
  • 15 (a)
OneToMany
Species with no ortholog for IGHG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHG1 Gene

ENSEMBL:
Gene Tree for IGHG1 (if available)
TreeFam:
Gene Tree for IGHG1 (if available)

Paralogs for IGHG1 Gene

Paralogs for IGHG1 Gene

Pseudogenes.org Pseudogenes for IGHG1 Gene

genes like me logo Genes that share paralogs with IGHG1: view

Variants for IGHG1 Gene

Sequence variations from dbSNP and Humsavar for IGHG1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_003886 -
VAR_003887 -
VAR_003888 -

Relevant External Links for IGHG1 Gene

HapMap Linkage Disequilibrium report
IGHG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGHG1 Gene

Disorders for IGHG1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for IGHG1 Gene including...

Search for IGHG1 Gene in MalaCards »

UniProtKB/Swiss-Prot

IGHG1_HUMAN
  • Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. {ECO:0000269 PubMed:11972529, ECO:0000269 PubMed:8943038}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

(1) University of Copenhagen DISEASES for IGHG1 Gene

Genatlas disease for IGHG1 Gene

infections,recurrent

Relevant External Links for IGHG1

Genetic Association Database (GAD)
IGHG1
Human Genome Epidemiology (HuGE) Navigator
IGHG1
genes like me logo Genes that share disorders with IGHG1: view

Publications for IGHG1 Gene

  1. IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab. (PMID: 19319024) Magdelaine-Beuzelin C. … Watier H. (Pharmacogenet. Genomics 2009) 3 23 48
  2. The rule of antibody structure. The primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie). III. The chymotryptic peptides of the H-chain, alignment of the tryptic peptides and discussion of the complete structure. (PMID: 826475) Ponstingl H. … Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1976) 3 4
  3. The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds. (PMID: 4923144) Gall W.E. … Edelman G.M. (Biochemistry 1970) 3 4
  4. The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1-H4. (PMID: 5489771) Cunningham B.A. … Edelman G.M. (Biochemistry 1970) 3 4
  5. The covalent structure of a human gamma G-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments H5-H7. (PMID: 5530842) Rutishauser U. … Edelman G.M. (Biochemistry 1970) 3 4

Products for IGHG1 Gene

Sources for IGHG1 Gene

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