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Aliases for IGHE Gene

Aliases for IGHE Gene

  • Immunoglobulin Heavy Constant Epsilon 2 3
  • Constant Region Of Heavy Chain Of IgE 3
  • Immunoglobulin Epsilon 3
  • IgE 3

External Ids for IGHE Gene

Previous GeneCards Identifiers for IGHE Gene

  • GC14U990033
  • GC14M100057
  • GC14M104038
  • GC14M105137
  • GC14M106066
  • GC14M086257
  • GC14M105604

Summaries for IGHE Gene

GeneCards Summary for IGHE Gene

IGHE (Immunoglobulin Heavy Constant Epsilon) is a Protein Coding gene. Diseases associated with IGHE include exercise induced anaphylaxis and toxocariasis. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

Gene Wiki entry for IGHE Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHE Gene

Genomics for IGHE Gene

Genomic Location for IGHE Gene

Chromosome:
14
Start:
105,599,941 bp from pter
End:
105,601,728 bp from pter
Size:
1,788 bases
Orientation:
Minus strand

Genomic View for IGHE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for IGHE Gene

No data available for Regulatory Elements for IGHE Gene

Proteins for IGHE Gene

  • Protein details for IGHE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01854-IGHE_HUMAN
    Recommended name:
    Ig epsilon chain C region
    Protein Accession:
    P01854

    Protein attributes for IGHE Gene

    Size:
    428 amino acids
    Molecular mass:
    47019 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB59424.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHE Gene

neXtProt entry for IGHE Gene

Proteomics data for IGHE Gene at MOPED

Post-translational modifications for IGHE Gene

  • Glycosylation at Asn 21, Asn 49, Asn 99, Asn 146, Asn 252, and Asn 275
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHE Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHE Gene

Domains & Families for IGHE Gene

Gene Families for IGHE Gene

Protein Domains for IGHE Gene

Suggested Antigen Peptide Sequences for IGHE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01854

UniProtKB/Swiss-Prot:

IGHE_HUMAN :
  • Contains 4 Ig-like (immunoglobulin-like) domains.
Domain:
  • Contains 4 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGHE: view

Function for IGHE Gene

Molecular function for IGHE Gene

GENATLAS Biochemistry:
immunoglobulin,epsilon

Gene Ontology (GO) - Molecular Function for IGHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 6300763
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGHE: view
genes like me logo Genes that share phenotypes with IGHE: view

Animal Models for IGHE Gene

MGI Knock Outs for IGHE:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for IGHE Gene

Localization for IGHE Gene

Gene Ontology (GO) - Cellular Components for IGHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0072562 blood microparticle IBA --
genes like me logo Genes that share ontologies with IGHE: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGHE Gene

Pathways & Interactions for IGHE Gene

genes like me logo Genes that share pathways with IGHE: view

Interacting Proteins for IGHE Gene

Gene Ontology (GO) - Biological Process for IGHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IBA --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006955 immune response NAS 6300763
GO:0006958 complement activation, classical pathway IBA --
genes like me logo Genes that share ontologies with IGHE: view

No data available for SIGNOR curated interactions for IGHE Gene

Drugs & Compounds for IGHE Gene

(70) Drugs for IGHE Gene - From: NovoSeek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Omalizumab Approved, Investigational Pharma antibody 133
Acetaminophen Approved Pharma 799
Albendazole Approved Pharma 68
Aprotinin Approved, Withdrawn Pharma Inhibitor of bovine pancreatic trypsin 24
Azelastine Approved Pharma 36

(49) Additional Compounds for IGHE Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Actinidin
Actinomycin D
adenylate
Allergens
aluminium hydroxide
genes like me logo Genes that share compounds with IGHE: view

Transcripts for IGHE Gene

mRNA/cDNA for IGHE Gene

(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHE Gene

No ASD Table

Relevant External Links for IGHE Gene

GeneLoc Exon Structure for
IGHE
ECgene alternative splicing isoforms for
IGHE

Expression for IGHE Gene

mRNA expression in normal human tissues for IGHE Gene

mRNA differential expression in normal tissues according to GTEx for IGHE Gene

This gene is overexpressed in Whole Blood (x9.8), Spleen (x8.9), Thyroid (x4.9), and Small Intestine - Terminal Ileum (x4.3).

Protein differential expression in normal tissues from HIPED for IGHE Gene

This gene is overexpressed in Gallbladder (44.4) and Peripheral blood mononuclear cells (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHE Gene



genes like me logo Genes that share expression patterns with IGHE: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IGHE Gene

Orthologs for IGHE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHE Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Igh-7 16
Ighe 36
  • 39 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGHE 36
  • 43 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGHE 36
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGHE 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGHE 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 36
  • 14 (a)
OneToMany
Species with no ortholog for IGHE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHE Gene

ENSEMBL:
Gene Tree for IGHE (if available)
TreeFam:
Gene Tree for IGHE (if available)

Paralogs for IGHE Gene

Paralogs for IGHE Gene

(2) SIMAP similar genes for IGHE Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IGHE Gene

genes like me logo Genes that share paralogs with IGHE: view

Variants for IGHE Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHE Gene

P01854-IGHE_HUMAN
The following alleles of IGHE are known: IGHE*01 and IGHE*02. The sequence shown is that of allele 02

Sequence variations from dbSNP and Humsavar for IGHE Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_003885 -
VAR_044229 -

Relevant External Links for IGHE Gene

HapMap Linkage Disequilibrium report
IGHE

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHE Gene

Disorders for IGHE Gene

MalaCards: The human disease database

(26) MalaCards diseases for IGHE Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
exercise induced anaphylaxis
  • exercise anaphylaxis
toxocariasis
  • toxocara infection
egg allergy
  • allergy to eggs
immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome
  • ipex syndrome
immunoglobulin g deficiency
  • igg deficiency
- elite association
Search IGHE in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGHE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGHE
genes like me logo Genes that share disorders with IGHE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGHE Gene

Publications for IGHE Gene

  1. Human leukocyte antigen (DR1)-DQB1*0501 and (DR15)-DQB1*0602 haplotypes are associated with humoral responses to early food allergens in children. (PMID: 20016199) Savilahti E.M. … Savilahti E. (Int. Arch. Allergy Immunol. 2010) 23 67
  2. Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralization. (PMID: 20132969) Schroeder J.T. … Liu M.C. (J. Allergy Clin. Immunol. 2010) 23 67
  3. Prenatal paracetamol exposure and asthma: further evidence against confounding. (PMID: 20356852) Shaheen S.O. … Henderson A.J. (Int J Epidemiol 2010) 23 67
  4. Public facility workers' immunological characteristics involved with development of respiratory allergic diseases in Korea. (PMID: 20424347) Heo Y. … Kim H.A. (Ind Health 2010) 23 67
  5. Recombinant allergen-based IgE testing to distinguish bee and wasp allergy. (PMID: 20466415) Mittermann I. … Valenta R. (J. Allergy Clin. Immunol. 2010) 23 67

Products for IGHE Gene

Sources for IGHE Gene

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