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Aliases for IGHE Gene

Aliases for IGHE Gene

  • Immunoglobulin Heavy Constant Epsilon 2 3 5
  • Constant Region Of Heavy Chain Of IgE 3
  • Immunoglobulin Epsilon 3
  • IgE 3

External Ids for IGHE Gene

Previous GeneCards Identifiers for IGHE Gene

  • GC14U990033
  • GC14M100057
  • GC14M104038
  • GC14M105137
  • GC14M106066
  • GC14M086257
  • GC14M105604
  • GC14M105619

Summaries for IGHE Gene

GeneCards Summary for IGHE Gene

IGHE (Immunoglobulin Heavy Constant Epsilon) is a Protein Coding gene. Diseases associated with IGHE include Latex Allergy and Allergic Rhinitis. Among its related pathways are IL4-mediated signaling events and Immune response Fc epsilon RI pathway. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

Gene Wiki entry for IGHE Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHE Gene

Genomics for IGHE Gene

Regulatory Elements for IGHE Gene

Enhancers for IGHE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IGHE on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHE Gene

105,599,941 bp from pter
105,601,728 bp from pter
1,788 bases
Minus strand

Genomic View for IGHE Gene

Genes around IGHE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHE Gene

Proteins for IGHE Gene

  • Protein details for IGHE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ig epsilon chain C region
    Protein Accession:

    Protein attributes for IGHE Gene

    428 amino acids
    Molecular mass:
    47019 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB59424.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHE Gene

neXtProt entry for IGHE Gene

Proteomics data for IGHE Gene at MOPED

Post-translational modifications for IGHE Gene

  • Glycosylation at Asn 21, Asn 49, Asn 99, Asn 146, Asn 252, and Asn 275
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHE Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHE Gene

Domains & Families for IGHE Gene

Gene Families for IGHE Gene

Protein Domains for IGHE Gene

Suggested Antigen Peptide Sequences for IGHE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 Ig-like (immunoglobulin-like) domains.
  • Contains 4 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGHE: view

Function for IGHE Gene

Molecular function for IGHE Gene

GENATLAS Biochemistry:

Phenotypes for IGHE Gene

GenomeRNAi human phenotypes for IGHE:
genes like me logo Genes that share phenotypes with IGHE: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHE Gene

Localization for IGHE Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IGHE Gene

Pathways & Interactions for IGHE Gene

genes like me logo Genes that share pathways with IGHE: view

Interacting Proteins for IGHE Gene

Gene Ontology (GO) - Biological Process for IGHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA,TAS --
GO:0050871 positive regulation of B cell activation IBA --
genes like me logo Genes that share ontologies with IGHE: view

No data available for SIGNOR curated interactions for IGHE Gene

Drugs & Compounds for IGHE Gene

(70) Drugs for IGHE Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Omalizumab Approved, Investigational Pharma antibody 138

(49) Additional Compounds for IGHE Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGHE: view

Transcripts for IGHE Gene

mRNA/cDNA for IGHE Gene

(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHE Gene

No ASD Table

Relevant External Links for IGHE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHE Gene

mRNA expression in normal human tissues for IGHE Gene

mRNA differential expression in normal tissues according to GTEx for IGHE Gene

This gene is overexpressed in Whole Blood (x9.8), Spleen (x8.9), Thyroid (x4.9), and Small Intestine - Terminal Ileum (x4.3).

Protein differential expression in normal tissues from HIPED for IGHE Gene

This gene is overexpressed in Gallbladder (44.4) and Peripheral blood mononuclear cells (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHE Gene

genes like me logo Genes that share expression patterns with IGHE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IGHE Gene

Orthologs for IGHE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHE Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IGHE 36
  • 43 (a)
(Canis familiaris)
Mammalia IGHE 36
  • 48 (a)
(Monodelphis domestica)
Mammalia IGHE 36
  • 41 (a)
(Mus musculus)
Mammalia Ighe 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia IGHE 36
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
(Danio rerio)
Actinopterygii ighv1-4 36
  • 14 (a)
Species with no ortholog for IGHE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHE Gene

Gene Tree for IGHE (if available)
Gene Tree for IGHE (if available)

Paralogs for IGHE Gene

Paralogs for IGHE Gene

(2) SIMAP similar genes for IGHE Gene using alignment to 1 proteins: Pseudogenes for IGHE Gene

genes like me logo Genes that share paralogs with IGHE: view

Variants for IGHE Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHE Gene

The following alleles of IGHE are known: IGHE*01 and IGHE*02. The sequence shown is that of allele 02.

Sequence variations from dbSNP and Humsavar for IGHE Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_003885 -
VAR_044229 -

No data available for Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for IGHE Gene

Disorders for IGHE Gene

MalaCards: The human disease database

(30) MalaCards diseases for IGHE Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
latex allergy
allergic rhinitis
  • atopic rhinitis
egg allergy
  • allergy to eggs
  • atopic hypersensitivity
hyper ige syndrome
  • hyper-ige recurrent infection syndrome
- elite association - COSMIC cancer census association via MalaCards
Search IGHE in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGHE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGHE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGHE Gene

Publications for IGHE Gene

  1. A model of the Fc of immunoglobulin E. (PMID: 3796618) Padlan E.A. … Davies D.R. (Mol. Immunol. 1986) 3 4 67
  2. Nanodomains in early and later phases of FcE9RI signalling. (PMID: 25658351) Holowka D. … Baird B. (Essays Biochem. 2015) 3
  3. Component-resolved IgE profiles in Austrian patients with a convincing history of peanut allergy. (PMID: 25765158) Ackerbauer D. … Breiteneder H. (Int. Arch. Allergy Immunol. 2015) 3
  4. IgE sensitization to lupine in bakers - cross-reactivity or co-sensitization to wheat flour? (PMID: 25765733) van Kampen V. … Raulf M. (Int. Arch. Allergy Immunol. 2015) 3
  5. Serum immunoglobulin E level and its impact on the pregnancy outcome associated with fetal growth restriction: a prospective cohort study. (PMID: 25966159) Xiong F. … Mao M. (Genet. Mol. Res. 2015) 3

Products for IGHE Gene

Sources for IGHE Gene