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Aliases for IGHE Gene

Aliases for IGHE Gene

  • Immunoglobulin Heavy Constant Epsilon 2 3
  • Constant Region Of Heavy Chain Of IgE 3
  • Immunoglobulin Epsilon 3
  • IgE 3

External Ids for IGHE Gene

Previous GeneCards Identifiers for IGHE Gene

  • GC14U990033
  • GC14M100057
  • GC14M104038
  • GC14M105137
  • GC14M106066
  • GC14M086257

Summaries for IGHE Gene

GeneCards Summary for IGHE Gene

IGHE (Immunoglobulin Heavy Constant Epsilon) is a Protein Coding gene. Diseases associated with IGHE include pyomyositis and fournier gangrene. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

Gene Wiki entry for IGHE Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHE Gene

Genomics for IGHE Gene

Genomic Location for IGHE Gene

105,599,941 bp from pter
105,601,728 bp from pter
1,788 bases
Minus strand

Genomic View for IGHE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGHE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHE Gene

No data available for Regulatory Elements for IGHE Gene

Proteins for IGHE Gene

  • Protein details for IGHE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ig epsilon chain C region
    Protein Accession:
    Secondary Accessions:

    Protein attributes for IGHE Gene

    428 amino acids
    Molecular mass:
    47019 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB59424.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHE Gene

neXtProt entry for IGHE Gene

Proteomics data for IGHE Gene at MOPED

Post-translational modifications for IGHE Gene

  • Glycosylation at Asn21, Asn49, Asn99, Asn146, Asn252, and Asn275
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHE Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGHE Gene

Domains for IGHE Gene

Gene Families for IGHE Gene

Protein Domains for IGHE Gene

Suggested Antigen Peptide Sequences for IGHE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 Ig-like (immunoglobulin-like) domains.
  • Contains 4 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGHE: view

Function for IGHE Gene

Molecular function for IGHE Gene

GENATLAS Biochemistry:

Gene Ontology (GO) - Molecular Function for IGHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 6300763
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGHE: view
genes like me logo Genes that share phenotypes with IGHE: view

Animal Models for IGHE Gene

MGI Knock Outs for IGHE:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IGHE Gene

Localization for IGHE Gene

Subcellular locations from

Jensen Localization Image for IGHE Gene COMPARTMENTS Subcellular localization image for IGHE gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IGHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with IGHE: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IGHE Gene

Pathways for IGHE Gene

genes like me logo Genes that share pathways with IGHE: view

Interacting Proteins for IGHE Gene

Gene Ontology (GO) - Biological Process for IGHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 6300763
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with IGHE: view

Compounds for IGHE Gene

(119) Novoseek inferred chemical compound relationships for IGHE Gene

Compound -log(P) Hits PubMed IDs
allergens 95.8 356
omalizumab 90.5 223
histamine 83.1 217
unicap 81.7 30
methacholine 75.1 111
genes like me logo Genes that share compounds with IGHE: view

Transcripts for IGHE Gene

mRNA/cDNA for IGHE Gene

(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHE Gene

No ASD Table

Relevant External Links for IGHE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHE Gene

mRNA expression in normal human tissues for IGHE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGHE Gene

This gene is overexpressed in Whole Blood (9.8), Spleen (8.9), Thyroid (4.9), and Small Intestine - Terminal Ileum (4.3).

Protein differential expression in normal tissues for IGHE Gene

This gene is overexpressed in Gallbladder (44.4) and Peripheral blood mononuclear cells (15.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGHE Gene

genes like me logo Genes that share expressions with IGHE: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for IGHE Gene

Orthologs for IGHE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHE Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Igh-7 16
Ighe 36
  • 39 (a)
(Bos Taurus)
Mammalia IGHE 36
  • 43 (a)
(Canis familiaris)
Mammalia IGHE 36
  • 48 (a)
(Monodelphis domestica)
Mammalia IGHE 36
  • 41 (a)
(Ornithorhynchus anatinus)
Mammalia IGHE 36
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
(Danio rerio)
Actinopterygii ighv1-4 36
  • 14 (a)
Species with no ortholog for IGHE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHE Gene

Gene Tree for IGHE (if available)
Gene Tree for IGHE (if available)

Paralogs for IGHE Gene

Paralogs for IGHE Gene

(2) SIMAP similar genes for IGHE Gene using alignment to 1 proteins: Pseudogenes for IGHE Gene

genes like me logo Genes that share paralogs with IGHE: view

Variants for IGHE Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHE Gene

The following alleles of IGHE are known: IGHE*01 and IGHE*02. The sequence shown is that of allele 02

Sequence variations from dbSNP and Humsavar for IGHE Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_003885 -
VAR_044229 -

Relevant External Links for IGHE Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for IGHE Gene

Disorders for IGHE Gene

(2) University of Copenhagen DISEASES for IGHE Gene

(97) Novoseek inferred disease relationships for IGHE Gene

Disease -log(P) Hits PubMed IDs
allergy 94.2 253
atopy 93.3 231
dermatitis atopic 92.3 249
asthma 91.1 391
asthma allergic 90 134
genes like me logo Genes that share disorders with IGHE: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHE Gene

Publications for IGHE Gene

  1. Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies. (PMID: 18356810) Eckman J.A. … Saini S.S. (J. Invest. Dermatol. 2008) 3 23
  2. Elevated serum immunoglobulin E (IgE): when to suspect hyper-IgE syndrome-A 10-year pediatric tertiary care center experience. (PMID: 19331717) Joshi A.Y. … Abraham R.S. (Allergy Asthma Proc 2009) 3 23
  3. Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line. (PMID: 6815656) Kenten J.H. … Gould H.J. (Proc. Natl. Acad. Sci. U.S.A. 1982) 3 4
  4. [Study on the correlation of IgE and GM-CSF contents with eosinophil accumulation in nasal polyp]. (PMID: 18254319) Tian C. … Du J. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007) 3 23
  5. A model of the Fc of immunoglobulin E. (PMID: 3796618) Padlan E.A. … Davies D.R. (Mol. Immunol. 1986) 3 4

Products for IGHE Gene

Sources for IGHE Gene

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