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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHE Gene

protein-coding   GIFtS: 41
GCID: GC14M106066

immunoglobulin heavy constant epsilon
 Explore 227 diseases affiliated with
IGHE via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGHE    

Aliases
for IGHE gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Heavy Constant Epsilon1 2
IgE2

External Ids:    HGNC: 55221   Entrez Gene: 34972   Ensembl: ENSG000002118917   OMIM: 1471805   UniProtKB: P018543   

Export aliases for IGHE gene to outside databases

Previous GC identifers: GC14U990033 GC14M100057 GC14M104038 GC14M105137 GC14M086257


Summaries
for IGHE gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for IGHE


Genomic Views
for IGHE gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHE
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHE gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106066:  view genomic region     (about GC identifiers)

Start:
 106,064,224 bp from pter      End:
 106,068,065 bp from pter
Size:
 3,842 bases      Orientation:
 minus strand

Proteins
for IGHE gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IGHE_HUMAN, P01854 (See protein sequence)
Recommended Name: Ig epsilon chain C region  
Size: 428 amino acids; 47019 Da
Sequence caution: Sequence=AAB59424.1; Type=Erroneous initiation;
6/13 PDB 3D structures from and Proteopedia for IGHE (see all 13):
1F6A (3D)        1FP5 (3D)        1G84 (3D)        1IGE (3D)        1O0V (3D)        2WQR (3D)    

Explore the universe of human proteins at neXtProt for IGHE: NX_P01854

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P01854

    • IGHE Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).


    ENSEMBL proteins: 
     ENSP00000374983   ENSP00000458614   ENSP00000458531  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for IGHE 
    GenScript Custom Purified and Recombinant Proteins Services for IGHE
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IGHE


    IGHE Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IGHE 
    GenScript Superior Antibodies for IGHE
    Novus Biologicals IGHE Antibodies
    Search for Antibodies for IGHE at Abcam  
    Uscn Antibodies for IGHE
    Search ThermoFisher Antibodies for IGHE

    Assay Products for IGHE: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IGHE
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IGHE

    Protein Domains /
    Families
    for IGHE gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGHE for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01854

    ProtoNet protein and cluster: P01854

    1 Blocks protein family: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: IGHE_HUMAN, P01854
    Similarity: Contains 4 Ig-like (immunoglobulin-like) domains


    Function
    for IGHE gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for IGHE:
    immunoglobulin,epsilon

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGHE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGHE
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    Browse OriGene siRNA
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGHE

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IGHE

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGHE
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGHE
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHE 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IGHE
    Search LifeMap BioReagents cell lines for IGHE

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHE

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding NAS6300763


    IGHE for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for IGHE: Igh-7Igh-tm1.1Lam Igh-7Igh-tm1Led
         4 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Igh-7):
     hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 

    IGHE for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IGHE gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response Fc epsilon RI pathway
    		Immune response Fc epsilon RI pathway1.00
    		Fc-epsilon receptor I signaling in mast cells0.33
    		Immune response_Fc epsilon RI pathway0.99
    2Immune response_NFAT in immune response
    		Immune response_NFAT in immune response1.00
    		Immune response NFAT in immune response0.91
    3Immune response_IL-4 signaling pathway
    		Immune response_IL-4 signaling pathway1.00
    		Immune response IL-4 signaling pathway0.98
    4IL4-mediated signaling events
    		IL4-mediated signaling events1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for IGHE
        Immune response IL-4 signaling pathway
    Immune response NFAT in immune response
    Immune response Fc epsilon RI pathway


    3 GeneGo (Thomson Reuters) Pathways for IGHE
        Immune response IL-4 signaling pathway
    Immune response Fc epsilon RI pathway
    Immune response NFAT in immune response

    2 BioSystems Pathways for IGHE 
        Fc-epsilon receptor I signaling in mast cells
    IL4-mediated signaling events



    IGHE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGHE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for IGHE (ENSP000003749834) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FOSENSP000003062454STRING: ENSP00000306245
    JUNENSP000003602664STRING: ENSP00000360266
    BCL6ENSP000002320144STRING: ENSP00000232014
    BTKENSP000003081764STRING: ENSP00000308176
    CBLENSP000002640334STRING: ENSP00000264033
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS6300763


    IGHE for ontologies           About GeneDecksing



    Drugs & Compounds
    for IGHE gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGHE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGHE

    1 DrugBank Compound for IGHE    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target----

    10/119 Novoseek chemical compound relationships for IGHE gene (see all 119)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergens 95.8 1757 9003217 (8), 9117883 (7), 15867862 (7), 17507082 (7) (see all 99)
    omalizumab 90.5 346 15478383 (7), 19130931 (7), 20139035 (6), 18269927 (6) (see all 99)
    histamine 83.1 523 8760789 (6), 1700888 (5), 10380774 (5), 7690780 (4) (see all 99)
    unicap 81.7 34 11258690 (3), 10432371 (1), 15934281 (1), 16124647 (1) (see all 28)
    methacholine 75.1 132 7613551 (3), 8959356 (3), 9487341 (3), 11476459 (3) (see all 89)
    hevein 66.2 39 9847442 (6), 9768591 (5), 9097919 (4), 11940078 (3) (see all 11)
    latex 65.6 491 11152171 (9), 10565556 (9), 7697481 (7), 18939728 (6) (see all 99)
    ovomucoid 64 90 9275136 (5), 17573723 (5), 11422162 (4), 1720303 (4) (see all 21)
    tarc 63.9 29 15813816 (5), 15864020 (4), 16543550 (3), 18173519 (2) (see all 16)
    actinidin 63.8 14 17845415 (4), 15536427 (2), 18727477 (1)

    Search CenterWatch for drugs/clinical trials and news about IGHE 

    Transcripts
    for IGHE gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000390541(uc001yrw.1 uc001yrx.2) ENST00000577108(uc001yru.2)
    ENST00000576077

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGHE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGHE
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    Browse OriGene siRNA
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGHE
    Clone
    Products:             		Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGHE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGHE
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHE 
    Primer
    Products:            		Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IGHE
      Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGHE
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHE

    5 AceView cDNA sequences:

    S71439 S55276 S55277 S55271 AK130825 

    GeneLoc Exon Structure


    Expression
    for IGHE gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGHE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IGHE expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IGHE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGHE
        SABiosciences Custom PCR Arrays for IGHE
    Primer
    Products:    		Browse OriGene genome-wide validated SYBR primer pairs
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    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IGHE
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    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHE
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHE

    Orthologs
    for IGHE gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IGHE gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 28(a)
    20(a)
    		 1 ↔ many
    possible ortholog
    		 GL343491.1(517133-525212)
    GL343491.1(485127-498368)
    zebrafish
    (Danio rerio)    		 Actinopterygii ighd6
    ighz6
    		 immunoglobulin heavy constant zeta
    		 6(a)
    14(a)
    		 many ↔ many
    many ↔ many
    		 3(34034542-34046885)
    3(34079980-34083059)


    ENSEMBL Gene Tree for IGHE (if available)
    TreeFam Gene Tree for IGHE (if available) 

    Paralogs
    for IGHE gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGHE gene
    IGHG22  IGHG32  IGHM2  IGHA12  IGHG42  IGHG12  IGHA22  
    2 SIMAP similar genes for IGHE using alignment to 1 protein entry:     IGHE_HUMAN:
    IGKC    IGHM

    IGHE for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for IGHE
    PGOHUM00000262208 PGOHUM00000247910 PGOHUM00000236371


    Genomic Variants
    for IGHE gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: IGHE_HUMAN, P01854
    Polymorphism: The following alleles of IGHE are known: IGHE*01 and IGHE*02. The sequence shown is that of allele 02

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHE
    DNA2.0 Custom Variant and Variant Library Synthesis for IGHE

    Disorders / Diseases
    for IGHE gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGHE for disorders           About GeneDecksing

    OMIM gene information: 147180    OMIM disorders: --

    20/227 diseases for IGHE (see all 227):    About MalaCards
    zap-70 deficiency    hyper-ige syndrome    alpha 1-antitrypsin deficiency    exercise induced anaphylaxis
    otitis media    brachial plexus lesion    eczema herpeticum    churg-strauss syndrome
    cough variant asthma    extrinsic allergic alveolitis    norwegian scabies    fournier gangrene
    staphylococcal toxic shock syndrome    pityriasis versicolor    eosinophilic gastroenteritis    constrictive pericarditis
    allergic bronchopulmonary aspergillosis    intrinsic asthma    sick building syndrome    spina bifida

    2 diseases from the University of Copenhagen DISEASES database for IGHE:
    Hypersensitivity reaction type I disease     Anisakiasis

    10/97 Novoseek disease relationships for IGHE gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergy 94.2 1000 19813686 (6), 9842212 (5), 7499673 (5), 16444083 (5) (see all 99)
    atopy 93.3 653 10457106 (5), 17355242 (5), 15737301 (5), 18221478 (5) (see all 99)
    dermatitis atopic 92.3 610 8615051 (6), 12368565 (5), 11678851 (5), 11035824 (5) (see all 99)
    asthma 91.1 1695 19647861 (9), 17498790 (9), 19913396 (7), 18951256 (7) (see all 99)
    asthma allergic 90 225 18602573 (5), 11544457 (4), 15182647 (4), 14687477 (3) (see all 99)
    allergic reaction 88.7 266 2314401 (4), 19178404 (3), 2040810 (3), 10224469 (2) (see all 99)
    allergy food 87.6 157 19568005 (3), 15969684 (3), 16285230 (3), 11467993 (3) (see all 99)
    hyper-ige syndrome 87.1 99 2116376 (4), 10485303 (4), 1720150 (4), 18380833 (3) (see all 52)
    hypersensitivity immediate 86.8 98 10795645 (2), 9561922 (2), 11716123 (2), 8517144 (2) (see all 81)
    allergic rhinitis 86.6 236 19159574 (5), 17225520 (5), 16340277 (3), 8343243 (3) (see all 99)


    Export disorders for IGHE gene to outside databases

    Publications
    for IGHE gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGHE gene, integrated from 9 sources (see all 3188):
    (articles sorted by number of sources associating them with IGHE)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A model of the Fc of immunoglobulin E. (PubMed id 3796618)1, 2 Padlan E.A. and Davies D.R. (1986)
    2. Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA. (PubMed id 6300763)1, 2 Seno M.... Honjo T. (1983)
    3. Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns. (PubMed id 6234164)1, 2 Flanagan J.G. and Rabbitts T.H. (1982)
    4. The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes. (PubMed id 6327276)1, 2 Ueda S.... Honjo T. (1982)
    5. Duplication and deletion in the human immunoglobulin epsilon genes. (PubMed id 6288268)1, 2 Max E.E.... Leder P. (1982)
    6. Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line. (PubMed id 6815656)1, 2 Kenten J.H.... Gould H.J. (1982)
    7. [Study on the correlation of IgE and GM-CSF contents with eosinophil accumulation in nasal polyp] (PubMed id 18254319)1, 9 Tian C....Du J. (2007)
    8. Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production. (PubMed id 15356573)1, 9 Hajoui O....Mazer B.D. (2004)
    9. IFN-gamma, IL-5, IL-6 and IgE in patients infected with Giardia intestinalis. (PubMed id 19419945)1, 9 Matowicka-Karna J....Kemona H. (2009)
    10. Elevated serum immunoglobulin E (IgE): when to suspect hyper-IgE syndrome-A 10-year pediatric tertiary care center experience. (PubMed id 19331717)1, 9 Joshi A.Y....Abraham R.S. (2009)

    External Searches for IGHE gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IGHE gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3497 HGNC: 5522 AceView: IGHE Ensembl:ENSG00000211891 euGenes: HUgn3497
    ECgene: IGHE H-InvDB: IGHE

    Other Databases showing IGHE gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IGHE gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGHE Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGHE The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHE&species=Homo+sapiens

    Intellectual Property
    for IGHE gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGHE gene:
    Search GeneIP for patents involving IGHE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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     IGHE Proteins, Antibodies, CLIAs, and ELISAs
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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