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IGHE Gene

protein-coding   GIFtS: 44
GCID: GC14M106066

Immunoglobulin Heavy Constant Epsilon

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Heavy Constant Epsilon1 2
IgE2

External Ids:    HGNC: 55221   Entrez Gene: 34972   Ensembl: ENSG000002118917   OMIM: 1471805   UniProtKB: P018543   

Export aliases for IGHE gene to outside databases

Previous GC identifers: GC14U990033 GC14M100057 GC14M104038 GC14M105137 GC14M086257


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGHE Gene:
IGHE (immunoglobulin heavy constant epsilon) is a protein-coding gene. Diseases associated with IGHE include papular urticaria, and heiner syndrome. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.

Gene Wiki entry for IGHE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IGHE
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IGHE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGHE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHE gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106066:  view genomic region     (about GC identifiers)

Start:
106,064,224 bp from pter      End:
106,068,065 bp from pter
Size:
3,842 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IGHE_HUMAN, P01854 (See protein sequence)
Recommended Name: Ig epsilon chain C region  
Size: 428 amino acids; 47019 Da
Sequence caution: Sequence=AAB59424.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for IGHE (see all 14):
1F6A (3D)        1FP5 (3D)        1G84 (3D)        1IGE (3D)        1O0V (3D)        2WQR (3D)    

Explore the universe of human proteins at neXtProt for IGHE: NX_P01854

Explore proteomics data for IGHE at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn21, Asn49, Asn99, Asn146, Asn252, Asn275
  • Modification sites at PhosphoSitePlus

  • See IGHE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000374983   ENSP00000458614   ENSP00000458531  
    Reactome Protein details: P01854

    IGHE Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec
    OriGene Custom Protein Services for IGHE
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    IGHE Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals IGHE Antibodies
    Abcam antibodies for IGHE
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for IGHE
    LSBio Antibodies in human, mouse, rat for IGHE

    IGHE Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IGHE
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGH: Immunoglobulins / IGH locus

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01854

    ProtoNet protein and cluster: P01854

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: IGHE_HUMAN, P01854
    Similarity: Contains 4 Ig-like (immunoglobulin-like) domains


    IGHE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for IGHE:
    immunoglobulin,epsilon

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding NAS6300763
    GO:0005515protein binding ----
         
    IGHE for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Igh-7):
     hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 

    IGHE for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IGHE: Igh-7Igh-tm1.1Lam Igh-7Igh-tm1Led

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGHE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGHE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGHE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGHE

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IGHE

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IGHE

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGHE
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGHE
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHE

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    IGHE for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGHE About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    2PI-3K cascade
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    Fc epsilon receptor (FCERI) signaling0.64
    3Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
    FCERI mediated Ca+2 mobilization0.47
    FCERI mediated MAPK activation0.45
    4Immune response NFAT in immune response
    Immune response NFAT in immune response0.55
    5Development IGF 1 receptor signaling
    Immune response IL 4 signaling pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for IGHE
        Immune response IL-4 signaling pathway
    Immune response Fc epsilon RI pathway
    Immune response NFAT in immune response

    2 BioSystems Pathways for IGHE
        IL4-mediated signaling events
    Fc-epsilon receptor I signaling in mast cells

    5 Reactome Pathways for IGHE
        FCERI mediated MAPK activation
    FCERI mediated NF-kB activation
    Fc epsilon receptor (FCERI) signaling
    Role of LAT2/NTAL/LAB on calcium mobilization
    FCERI mediated Ca+2 mobilization



    IGHE for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGHE
    Interactions:

        GeneGlobe Interaction Network for IGHE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IGHE (ENSP000003749834) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FOSENSP000003062454STRING: ENSP00000306245
    JUNENSP000003602664STRING: ENSP00000360266
    BCL6ENSP000002320144STRING: ENSP00000232014
    BTKENSP000003081764STRING: ENSP00000308176
    CBLENSP000002640334STRING: ENSP00000264033
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS6300763
    GO:0038095Fc-epsilon receptor signaling pathway TAS--
    GO:0045087innate immune response TAS--

    IGHE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGHE

    1 DrugBank Compound for IGHE    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target----

    Selected Novoseek inferred chemical compound relationships for IGHE gene (see all 119)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergens 95.8 1757 9003217 (8), 9117883 (7), 15867862 (7), 17507082 (7) (see all 99)
    omalizumab 90.5 346 15478383 (7), 19130931 (7), 20139035 (6), 18269927 (6) (see all 99)
    histamine 83.1 523 8760789 (6), 1700888 (5), 10380774 (5), 7690780 (4) (see all 99)
    unicap 81.7 34 11258690 (3), 10432371 (1), 15934281 (1), 16124647 (1) (see all 28)
    methacholine 75.1 132 7613551 (3), 8959356 (3), 9487341 (3), 11476459 (3) (see all 89)
    hevein 66.2 39 9847442 (6), 9768591 (5), 9097919 (4), 11940078 (3) (see all 11)
    latex 65.6 491 11152171 (9), 10565556 (9), 7697481 (7), 18939728 (6) (see all 99)
    ovomucoid 64 90 9275136 (5), 17573723 (5), 11422162 (4), 1720303 (4) (see all 21)
    tarc 63.9 29 15813816 (5), 15864020 (4), 16543550 (3), 18173519 (2) (see all 16)
    actinidin 63.8 14 17845415 (4), 15536427 (2), 18727477 (1)



    IGHE for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000390541(uc001yrw.1 uc001yrx.2) ENST00000577108(uc001yru.2)
    ENST00000576077
    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate IGHE
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse OriGene RNAi
    Predesigned siRNA for gene silencing in human, mouse, rat IGHE
    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGHE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGHE
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHE
    Primer
    Products:
        
    Browse OriGene qPCR
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IGHE
      QuantiTect SYBR Green Assays in human, mouse, rat IGHE
      QuantiFast Probe-based Assays in human, mouse, rat IGHE

    5 AceView cDNA sequences:

    S55277 S71439 S55276 S55271 AK130825 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGHE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGHE Expression
    About this image


    IGHE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
    IGHE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGHE Protein Expression
        Custom PCR Arrays for IGHE
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGHE gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igh-75 immunoglobulin heavy chain 7 (heavy chain of IgE)   --   12 113264521 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    28(a)
    1 → many
    GL343491.1(461752-525278)
    zebrafish
    (Danio rerio)
    Actinopterygii ighv1-46
    immunoglobulin heavy variable 1-4
    14(a)
    1 → many
    3(34048543-34145418) ENSDARG00000096355


    ENSEMBL Gene Tree for IGHE (if available)
    TreeFam Gene Tree for IGHE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGHE gene
    IGHG22  IGHA12  IGHM2  IGHG32  IGHG42  IGHG12  IGHA22  
    2 SIMAP similar genes for IGHE using alignment to 1 protein entry:     IGHE_HUMAN:
    IGKC    IGHM

    IGHE for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for IGHE
    PGOHUM00000262208 PGOHUM00000247910 PGOHUM00000236371


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    IGHE_HUMAN, P01854: The following alleles of IGHE are known: IGHE*01 and IGHE*02. The sequence shown is that of allele
    02


    2 SNPs for IGHE    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0442294
    ----see VAR_0442292 W C mis40--------
    VAR_0038854
    ----see VAR_0038852 W L mis40--------

    HapMap Linkage Disequilibrium report for IGHE (106064224 - 106068065 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IGHE: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGHE
    DNA2.0 Custom Variant and Variant Library Synthesis for IGHE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147180    OMIM disorders: --

    Selected diseases for IGHE (see all 220):    
    About MalaCards
    papular urticaria    heiner syndrome    vernal keratitis    anisakiasis
    pyomyositis    chronic conjunctivitis    exercise induced anaphylaxis    bronchial disease
    zap-70 deficiency    ipex syndrome    norwegian scabies    toxocariasis
    helminthiasis    papillary conjunctivitis    eosinophilic gastroenteritis    staphylococcal toxic shock syndrome
    cd40 ligand deficiency    brachial plexus lesion    paragonimiasis    cough variant asthma

    2 diseases from the University of Copenhagen DISEASES database for IGHE:
    Hypersensitivity reaction type I disease     Anisakiasis

    IGHE for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for IGHE gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergy 94.2 1000 19813686 (6), 9842212 (5), 7499673 (5), 16444083 (5) (see all 99)
    atopy 93.3 653 10457106 (5), 17355242 (5), 15737301 (5), 18221478 (5) (see all 99)
    dermatitis atopic 92.3 610 8615051 (6), 12368565 (5), 11678851 (5), 11035824 (5) (see all 99)
    asthma 91.1 1695 19647861 (9), 17498790 (9), 19913396 (7), 18951256 (7) (see all 99)
    asthma allergic 90 225 18602573 (5), 11544457 (4), 15182647 (4), 14687477 (3) (see all 99)
    allergic reaction 88.7 266 2314401 (4), 19178404 (3), 2040810 (3), 10224469 (2) (see all 99)
    allergy food 87.6 157 19568005 (3), 15969684 (3), 16285230 (3), 11467993 (3) (see all 99)
    hyper-ige syndrome 87.1 99 2116376 (4), 10485303 (4), 1720150 (4), 18380833 (3) (see all 52)
    hypersensitivity immediate 86.8 98 10795645 (2), 9561922 (2), 11716123 (2), 8517144 (2) (see all 81)
    allergic rhinitis 86.6 236 19159574 (5), 17225520 (5), 16340277 (3), 8343243 (3) (see all 99)


    Export disorders for IGHE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGHE gene, integrated from 10 sources (see all 3189):
    (articles sorted by number of sources associating them with IGHE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A model of the Fc of immunoglobulin E. (PubMed id 3796618)1, 2 Padlan E.A. and Davies D.R. (Mol. Immunol. 1986)
    2. Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA. (PubMed id 6300763)1, 2 Seno M.... Honjo T. (Nucleic Acids Res. 1983)
    3. The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes. (PubMed id 6234164)1, 2 Flanagan J.G. and Rabbitts T.H. (EMBO J. 1982)
    4. Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns. (PubMed id 6327276)1, 2 Ueda S.... Honjo T. (EMBO J. 1982)
    5. Duplication and deletion in the human immunoglobulin epsilon genes. (PubMed id 6288268)1, 2 Max E.E.... Leder P. (Cell 1982)
    6. Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line. (PubMed id 6815656)1, 2 Kenten J.H.... Gould H.J. (Proc. Natl. Acad. Sci. U.S.A. 1982)
    7. [Study on the correlation of IgE and GM-CSF contents with eosinophil accumulation in nasal polyp]. (PubMed id 18254319)1, 9 Tian C....Du J. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007)
    8. Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production. (PubMed id 15356573)1, 9 Hajoui O....Mazer B.D. (J. Allergy Clin. Immunol. 2004)
    9. IFN-gamma, IL-5, IL-6 and IgE in patients infected with Giardia intestinalis. (PubMed id 19419945)1, 9 Matowicka-Karna J....Kemona H. (Folia Histochem. Cytobiol. 2009)
    10. Elevated serum immunoglobulin E (IgE): when to suspect hyper-IgE syndrome-A 10-year pediatric tertiary care center experience. (PubMed id 19331717)1, 9 Joshi A.Y....Abraham R.S. (Allergy Asthma Proc 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3497 HGNC: 5522 AceView: IGHE Ensembl:ENSG00000211891 euGenes: HUgn3497
    ECgene: IGHE H-InvDB: IGHE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGHE Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGHE The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHE&species=Homo+sapiens

    (Patent information from GeneIP,
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    Patent Information for IGHE gene:
    Search GeneIP for patents involving IGHE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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