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Aliases for IGHD1-1 Gene

Aliases for IGHD1-1 Gene

  • Immunoglobulin Heavy Diversity 1-1 2 3 5
  • IGHD11 3

External Ids for IGHD1-1 Gene

Previous GeneCards Identifiers for IGHD1-1 Gene

  • GC14U990265
  • GC14M104357
  • GC14M105456
  • GC14M106407
  • GC14M106413
  • GC14M106417
  • GC14M106420
  • GC14M106461
  • GC14M106526
  • GC14M106747
  • GC14M107401
  • GC14M107593
  • GC14M105924
  • GC14M105983
  • GC14M106075
  • GC14M106156
  • GC14M106261

Summaries for IGHD1-1 Gene

GeneCards Summary for IGHD1-1 Gene

IGHD1-1 (Immunoglobulin Heavy Diversity 1-1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGHD1-1 Gene

  • D region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHD1-1 Gene

Genomics for IGHD1-1 Gene

Regulatory Elements for IGHD1-1 Gene

Enhancers for IGHD1-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G105919 0.2 dbSUPER 0.7 -0.2 -216 0.7 IGHD1-1 GC14P105930
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGHD1-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHD1-1 Gene

Chromosome:
14
Start:
105,919,502 bp from pter
End:
105,919,518 bp from pter
Size:
17 bases
Orientation:
Minus strand

Genomic View for IGHD1-1 Gene

Genes around IGHD1-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHD1-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHD1-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHD1-1 Gene

Proteins for IGHD1-1 Gene

  • Protein details for IGHD1-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DOY5-HD101_HUMAN
    Recommended name:
    Immunoglobulin heavy diversity 1-1
    Protein Accession:
    P0DOY5

    Protein attributes for IGHD1-1 Gene

    Size:
    5 amino acids
    Molecular mass:
    435 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGHD1-1 Gene

Post-translational modifications for IGHD1-1 Gene

No Post-translational modifications

Other Protein References for IGHD1-1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHD1-1 Gene

Domains & Families for IGHD1-1 Gene

Gene Families for IGHD1-1 Gene

Protein Domains for IGHD1-1 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHD1-1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHD1-1 Gene

Function for IGHD1-1 Gene

Molecular function for IGHD1-1 Gene

UniProtKB/Swiss-Prot Function:
D region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHD1-1 Gene

Localization for IGHD1-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHD1-1 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHD1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGHD1-1: view

No data available for Subcellular locations from COMPARTMENTS for IGHD1-1 Gene

Pathways & Interactions for IGHD1-1 Gene

SuperPathways for IGHD1-1 Gene

No Data Available

Interacting Proteins for IGHD1-1 Gene

Gene Ontology (GO) - Biological Process for IGHD1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IGHD1-1: view

No data available for Pathways by source and SIGNOR curated interactions for IGHD1-1 Gene

Drugs & Compounds for IGHD1-1 Gene

No Compound Related Data Available

Transcripts for IGHD1-1 Gene

mRNA/cDNA for IGHD1-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHD1-1 Gene

No ASD Table

Relevant External Links for IGHD1-1 Gene

GeneLoc Exon Structure for
IGHD1-1
ECgene alternative splicing isoforms for
IGHD1-1

Expression for IGHD1-1 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHD1-1 Gene

Orthologs for IGHD1-1 Gene

Evolution for IGHD1-1 Gene

ENSEMBL:
Gene Tree for IGHD1-1 (if available)
TreeFam:
Gene Tree for IGHD1-1 (if available)

No data available for Orthologs for IGHD1-1 Gene

Paralogs for IGHD1-1 Gene

No data available for Paralogs for IGHD1-1 Gene

Variants for IGHD1-1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHD1-1 Gene

HD101_HUMAN-P0DOY5
There are several alleles. The sequence shown is that of IMGT allele IGHD1-1*01.

Relevant External Links for IGHD1-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHD1-1

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHD1-1 Gene

Disorders for IGHD1-1 Gene

No disorders were found for IGHD1-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHD1-1 Gene

Publications for IGHD1-1 Gene

  1. The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus. (PMID: 3138112) Buluwela L. … Rabbitts T.H. (EMBO J. 1988) 2 3 64
  2. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64

Products for IGHD1-1 Gene

Sources for IGHD1-1 Gene

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