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Aliases for IGHD Gene

Aliases for IGHD Gene

  • Immunoglobulin Heavy Constant Delta 2 3
  • Constant Region Of Heavy Chain Of IgD 2
  • Immunoglobulin Delta 2

External Ids for IGHD Gene

Previous GeneCards Identifiers for IGHD Gene

  • GC14U990032
  • GC14M104276
  • GC14M105375
  • GC14M106303
  • GC14M086437

Summaries for IGHD Gene

GeneCards Summary for IGHD Gene

IGHD (Immunoglobulin Heavy Constant Delta) is a Protein Coding gene. Diseases associated with IGHD include chronic lymphocytic leukemia. Among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include antigen binding.

UniProtKB/Swiss-Prot for IGHD Gene

  • IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

Gene Wiki entry for IGHD Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHD Gene

Genomics for IGHD Gene

Genomic Location for IGHD Gene

Start:
105,836,765 bp from pter
End:
105,845,678 bp from pter
Size:
8,914 bases
Orientation:
Minus strand

Genomic View for IGHD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGHD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHD Gene

No data available for Regulatory Elements for IGHD Gene

Proteins for IGHD Gene

  • Protein details for IGHD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01880-IGHD_HUMAN
    Recommended name:
    Ig delta chain C region
    Protein Accession:
    P01880
    Secondary Accessions:
    • Q6P4I8
    • Q8WU38

    Protein attributes for IGHD Gene

    Size:
    384 amino acids
    Molecular mass:
    42254 Da
    Quaternary structure:
    • Immunoglobulin (Ig) molecules consist of two chains, one heavy chain (which can be alpha, delta, epsilon, gamma or mu) and one light chain (which can be kappa or lambda) each consisting of a variable and a constant region. An IgD molecule contains thus a delta heavy chain combined with either a kappa or a lambda light chains. Kappa light chains are found predominantly on the membrane IgD (mIgD) form and lambda on the secreted IgD (sIgD) form, this fact is poorly understood. Membrane-bound IgD molecules are non-covalently associated with a heterodimer of CD79A and CD79B
    Miscellaneous:
    • IgD is not present in every species and this does not relate to phylogeny and evolution. IgD is present in primates, dog, mouse and rat whereas it is undetectable in rabbit, guinea pig, swine, cattle, sheep and Xenopus

    Three dimensional structures from OCA and Proteopedia for IGHD Gene

    Alternative splice isoforms for IGHD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGHD Gene

Proteomics data for IGHD Gene at MOPED

Post-translational modifications for IGHD Gene

  • Glycosylation at Ser109, Ser110, Thr113, Thr126, Thr127, Thr131, Thr132, Asn225, Asn316, and Asn367
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHD Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGHD Gene

Domains for IGHD Gene

Gene Families for IGHD Gene

HGNC:
  • IGH :Immunoglobulins / IGH locus

Protein Domains for IGHD Gene

Suggested Antigen Peptide Sequences for IGHD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01880

UniProtKB/Swiss-Prot:

IGHD_HUMAN :
  • P01880
Domain:
  • Contains 3 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGHD: view

Function for IGHD Gene

Molecular function for IGHD Gene

UniProtKB/Swiss-Prot Function: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

Gene Ontology (GO) - Molecular Function for IGHD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 6787589
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGHD: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IGHD Gene

Localization for IGHD Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHD Gene

Isoform 1: Secreted.
Isoform 2: Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for IGHD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGHD: view

No data available for Subcellular locations from COMPARTMENTS for IGHD Gene

Pathways for IGHD Gene

genes like me logo Genes that share pathways with IGHD: view

Interacting Proteins for IGHD Gene

Gene Ontology (GO) - Biological Process for IGHD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 6787589
genes like me logo Genes that share ontologies with IGHD: view

Transcripts for IGHD Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGHD Gene

No ASD Table

Relevant External Links for IGHD Gene

GeneLoc Exon Structure for
IGHD
ECgene alternative splicing isoforms for
IGHD

Expression for IGHD Gene

mRNA expression in normal human tissues for IGHD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGHD Gene

This gene is overexpressed in Spleen (9.4), Whole Blood (6.6), and Lung (5.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGHD Gene

genes like me logo Genes that share expressions with IGHD: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IGHD Gene

Orthologs for IGHD Gene

Evolution for IGHD Gene

ENSEMBL:
Gene Tree for IGHD (if available)
TreeFam:
Gene Tree for IGHD (if available)

No data available for Orthologs for IGHD Gene

Paralogs for IGHD Gene

Selected SIMAP similar genes for IGHD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGHD: view

No data available for Paralogs for IGHD Gene

Variants for IGHD Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHD Gene

P01880-IGHD_HUMAN
The following alleles of IGHD are known: IGHD*01 and IGHD*02. They are identical at protein level

Relevant External Links for IGHD Gene

HapMap Linkage Disequilibrium report
IGHD
Locus Specific Mutation Databases (LSDB)
IGHD

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGHD Gene

Disorders for IGHD Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for IGHD Gene including...

Search for IGHD Gene in MalaCards »
genes like me logo Genes that share disorders with IGHD: view

No data available for UniProtKB/Swiss-Prot for IGHD Gene

Publications for IGHD Gene

  1. Human immunoglobulin D: genomic sequence of the delta heavy chain. (PMID: 3922054) White M.B. … Blattner F.R. (Science 1985) 2 3 4
  2. Complete amino acid sequence of the Fc region of a human delta chain. (PMID: 6785754) Shinoda T. … Shimizu A. (Proc. Natl. Acad. Sci. U.S.A. 1981) 3 4
  3. Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function. (PMID: 6787589) Lin L.-C. … Putnam F.W. (Proc. Natl. Acad. Sci. U.S.A. 1981) 3 4
  4. Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD. (PMID: 6947220) Putnam F.W. … Lin L.-C. (Proc. Natl. Acad. Sci. U.S.A. 1981) 3 4
  5. Amino acid sequence and location of the three glycopeptides in the Fc region of human immunoglobulin D. (PMID: 7008791) Takayasu T. … Shinoda T. (Biochem. Biophys. Res. Commun. 1980) 3 4

Products for IGHD Gene

Sources for IGHD Gene

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