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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHD Gene

protein-coding   GIFtS: 35
GCID: GC14M106303

immunoglobulin heavy constant delta
 Explore 5 diseases affiliated with
IGHD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGHD    

Aliases
for IGHD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Heavy Constant Delta1 2
FLJ003821
FLJ467271
MGC296331

External Ids:    HGNC: 54801   Entrez Gene: 34952   Ensembl: ENSG000002118987   OMIM: 1471705   UniProtKB: P018803   

Export aliases for IGHD gene to outside databases

Previous GC identifers: GC14U990032 GC14M104276 GC14M105375 GC14M086437


Summaries
for IGHD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: IGHD_HUMAN, P01880
Function: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed
with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein
tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that
of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen
binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD
also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main
producers of cytokines in vitro in the presence of IgD

Gene Wiki entry for IGHD


Genomic Views
for IGHD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHD
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHD gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106303:  view genomic region     (about GC identifiers)

Start:
 106,303,099 bp from pter      End:
 106,312,010 bp from pter
Size:
 8,912 bases      Orientation:
 minus strand

Proteins
for IGHD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IGHD_HUMAN, P01880 (See protein sequence)
Recommended Name: Ig delta chain C region  
Size: 384 amino acids; 42254 Da
Subunit: Immunoglobulin (Ig) molecules consist of two chains, one heavy chain (which can be alpha, delta, epsilon,
gamma or mu) and one light chain (which can be kappa or lambda) each consisting of a variable and a constant region.
An IgD molecule contains thus a delta heavy chain combined with either a kappa or a lambda light chains. Kappa light
chains are found predominantly on the membrane IgD (mIgD) form and lambda on the secreted IgD (sIgD) form, this fact
is poorly understood. Membrane-bound IgD molecules are non-covalently associated with a heterodimer of CD79A and CD79B
Subcellular location: Isoform 1: Secreted
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein
Miscellaneous: IgD is not present in every species and this does not relate to phylogeny and evolution. IgD is present
in primates, dog, mouse and rat whereas it is undetectable in rabbit, guinea pig, swine, cattle, sheep and Xenopus
1 PDB 3D structure from and Proteopedia for IGHD:
1ZVO (3D)    
Secondary accessions: Q6P4I8 Q8WU38
Alternative splicing: 2 isoforms:  P01880-1   P01880-2   

Explore the universe of human proteins at neXtProt for IGHD: NX_P01880

IGHD Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000374998  
Reactome Protein details: P01880
Human Recombinant Protein Products: 
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Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--


IGHD for ontologies           About GeneDecksing



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Protein Domains /
Families
for IGHD gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGHD for domains           About GeneDecksing

5 InterPro domains/families:
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like_dom
 IPR003006 Ig/MHC_CS
 IPR013151 Immunoglobulin

Graphical View of Domain Structure for InterPro Entry P01880

ProtoNet protein and cluster: P01880

1 Blocks protein family: IPB003597 Immunoglobulin C-type

UniProtKB/Swiss-Prot: IGHD_HUMAN, P01880
Similarity: Contains 3 Ig-like (immunoglobulin-like) domains


Function
for IGHD gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: IGHD_HUMAN, P01880
Function: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed
with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein
tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that
of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen
binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD
also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main
producers of cytokines in vitro in the presence of IgD

miRNA
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Inhib. RNA
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In Situ Assay
Products:   
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding NAS6787589


IGHD for ontologies           About GeneDecksing



Pathways & Interactions
for IGHD gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Assembly of Signalosomes at the Activated BCR
Assembly of Signalosomes at the Activated BCR1.00
Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)0.45
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.78
2Immune System
Immune System1.00
Adaptive Immune System0.59
3Signaling by the B Cell Receptor (BCR)
Signaling by the B Cell Receptor (BCR)1.00

Pathway sources
See GeneCards unified pathways
Show all pathways


5/6        Reactome Pathways for IGHD (see all 6)
    Assembly of Signalosomes at the Activated BCR
Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
Adaptive Immune System
Immune System



IGHD for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHD

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for IGHD (ENSP000003749984) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IGLC2ENSP000003748564STRING: ENSP00000374856
BCAP29ENSP000004007184STRING: ENSP00000400718
BCAP31ENSP000003923304STRING: ENSP00000392330
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS6787589


IGHD for ontologies           About GeneDecksing



Drugs & Compounds
for IGHD gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHD
Search CenterWatch for drugs/clinical trials and news about IGHD 

Transcripts
for IGHD gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390556(uc001ysj.3 uc001ysk.1 uc001ysl.1 uc001ysm.2 uc001ysn.1)


miRNA
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Inhib. RNA
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Clone
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Primer
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24/413 AceView cDNA sequences (see all 413):

CR592950 AI453840 CR597050 BM694872 CR625295 CA428378 CR595172 BX414017 
CA426988 CR619868 BF435693 CR608814 CA427135 BU616690 BU615732 CR611134 
BX161420 CR612969 BQ707700 CR601777 BG397823 CR612308 CR606782 CR607337 

GeneLoc Exon Structure


Expression
for IGHD gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGHD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See IGHD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGHD
    SABiosciences Custom PCR Arrays for IGHD
Primer
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In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHD

Orthologs
for IGHD gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGHD gene from 2/3 species (see all 3)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
lizard
(Anolis carolinensis)		 Reptilia --
 --
 17(a)
 possible ortholog
 GL343491.1(485127-498368)
zebrafish
(Danio rerio)		 Actinopterygii ighd6
ighz6
 immunoglobulin heavy constant zeta
 5(a)
14(a)
 many ↔ many
many ↔ many
 3(34034542-34046885)
3(34079980-34083059)


ENSEMBL Gene Tree for IGHD (if available)
TreeFam Gene Tree for IGHD (if available) 

Paralogs
for IGHD gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for IGHD gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: IGHD_HUMAN, P01880
Polymorphism: The following alleles of IGHD are known: IGHD*01 and IGHD*02. They are identical at protein level


Locus Specific Mutation Databases (LSDB): IGHD

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Disorders / Diseases
for IGHD gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGHD for disorders           About GeneDecksing

OMIM gene information: 147170    OMIM disorders: --

5 diseases for IGHD:    About MalaCards
haemophilus influenzae    chronic lymphocytic leukemia    lymphocytic leukemia    influenza
leukemia


Export disorders for IGHD gene to outside databases

Publications
for IGHD gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGHD gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with IGHD)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Human immunoglobulin D: genomic sequence of the delta heavy chain. (PubMed id 3922054)1, 2, 3 White M.B....Blattner F.R. (1985)
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
  3. Amino acid sequence of galactosamine-containing glycopeptides in the hinge region of a human immunoglobulin D. (PubMed id 7092891)1, 2 Takayasu T.... Munekata E. (1982)
  4. Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD. (PubMed id 6947220)1, 2 Putnam F.W.... Lin L.-C. (1981)
  5. Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function. (PubMed id 6787589)1, 2 Lin L.-C. and Putnam F.W. (1981)
  6. Complete amino acid sequence of the Fc region of a human delta chain. (PubMed id 6785754)1, 2 Shinoda T.... Shimizu A. (1981)
  7. Amino acid sequence and location of the three glycopeptides in the Fc region of human immunoglobulin D. (PubMed id 7008791)1, 2 Takayasu T.... Shinoda T. (1980)
  8. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
  9. Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia. (PubMed id 17169423)1 Lee C.E....Collins A.M. (2007)
  10. Characterization of the IgD binding site of encapsulated Haemophilus influenzae serotype b. (PubMed id 17475860)1 Samuelsson M....Riesbeck K. (2007)

External Searches for IGHD gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGHD gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3495 HGNC: 5480 AceView: IGHD_ Ensembl:ENSG00000211898 euGenes: HUgn3495
ECgene: IGHD H-InvDB: IGHD

Other Databases showing IGHD gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGHD gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGHD Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHD The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHD&species=Homo+sapiens

Intellectual Property
for IGHD gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGHD gene:
Search GeneIP for patents involving IGHD

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGHD gene

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About This Section

 
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