Aliases for IGHD Gene
External Ids for IGHD Gene
Previous GeneCards Identifiers for IGHD Gene
GeneCards Summary for IGHD Gene
IGHD (Immunoglobulin Heavy Constant Delta) is a Protein Coding gene. Diseases associated with IGHD include congenital hypogammaglobulinemia. Among its related pathways are Immune System and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include antigen binding.
UniProtKB/Swiss-Prot for IGHD Gene
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.