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Aliases for IGHA2 Gene

Aliases for IGHA2 Gene

  • Immunoglobulin Heavy Constant Alpha 2 (A2m Marker) 2 3 5
  • Ig Alpha-2 Chain C Region BUT 4
  • Ig Alpha-2 Chain C Region LAN 4
  • Ig Alpha-2 Chain C Region 4

External Ids for IGHA2 Gene

Previous GeneCards Identifiers for IGHA2 Gene

  • GC14U990031
  • GC14M100045
  • GC14M104024
  • GC14M105124
  • GC14M106050
  • GC14M105588
  • GC14M105614
  • GC14M105625
  • GC14M105635
  • GC14M105655

Summaries for IGHA2 Gene

GeneCards Summary for IGHA2 Gene

IGHA2 (Immunoglobulin Heavy Constant Alpha 2 (A2m Marker)) is a Protein Coding gene. GO annotations related to this gene include antigen binding and immunoglobulin receptor binding. An important paralog of this gene is IGHA1.

UniProtKB/Swiss-Prot for IGHA2 Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).

Gene Wiki entry for IGHA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHA2 Gene

Genomics for IGHA2 Gene

Regulatory Elements for IGHA2 Gene

Enhancers for IGHA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G105192 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +392.0 392010 7.2 PKNOX1 ATF1 SIN3A ZNF2 ZBTB7B GLIS2 GATA2 ZNF207 FOS ZNF263 BTBD6 TMEM121 PACS2 NUDT14 IGHA2 CRIP2 JAG2 PIR42636
GH14G105585 1 ENCODE dbSUPER 0.7 +2.4 2404 1.0 HDGF CTCF USF1 NFIB YBX1 SALL2 CTBP1 GATA3 ZNF366 SCRT2 TMEM121 PACS2 IGHA2 ELK2BP
GH14G105566 1.5 FANTOM5 ENCODE dbSUPER 0.4 +18.7 18666 6.2 HDGF ZNF133 YBX1 GLI4 ZNF48 ZNF2 ZBTB7B GLIS2 ZNF143 ZNF207 ENSG00000257270 RPS20P33 LINC00638 CDCA4 IGHA2 ELK2BP
GH14G105580 1.1 ENCODE dbSUPER 0.4 +6.5 6535 2.6 HDGF TBL1XR1 ZNF48 ZNF143 FOS RELB IKZF2 CREM ZNF202 JUNB INF2 IGHA2 ELK2BP
GH14G105575 1.1 ENCODE dbSUPER 0.4 +11.3 11330 3.2 HDGF INSM2 YBX1 ZNF48 ZBTB7B ZBTB40 GLIS2 ZNF366 ZNF143 ZNF202 IGHA2 ELK2BP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGHA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHA2 Gene

Chromosome:
14
Start:
105,586,889 bp from pter
End:
105,588,395 bp from pter
Size:
1,507 bases
Orientation:
Minus strand

Genomic View for IGHA2 Gene

Genes around IGHA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHA2 Gene

Proteins for IGHA2 Gene

  • Protein details for IGHA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01877-IGHA2_HUMAN
    Recommended name:
    Immunoglobulin heavy constant alpha 2
    Protein Accession:
    P01877
    Secondary Accessions:
    • A0A075B6N7

    Protein attributes for IGHA2 Gene

    Size:
    340 amino acids
    Molecular mass:
    36591 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked (PubMed:20176268). Monomeric or polymeric (PubMed:2241915).
    SequenceCaution:
    • Sequence=AAB59396.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHA2 Gene

neXtProt entry for IGHA2 Gene

Post-translational modifications for IGHA2 Gene

  • Glycosylation at posLast=4747, isoforms=131, isoforms=205, and posLast=327327
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHA2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHA2 Gene

Domains & Families for IGHA2 Gene

Gene Families for IGHA2 Gene

Protein Domains for IGHA2 Gene

Suggested Antigen Peptide Sequences for IGHA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHA2: view

No data available for UniProtKB/Swiss-Prot for IGHA2 Gene

Function for IGHA2 Gene

Molecular function for IGHA2 Gene

GENATLAS Biochemistry:
immunoglobulin,alpha 2 (A2M marker)
UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).

Gene Ontology (GO) - Molecular Function for IGHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 6421489
GO:0034987 contributes_to immunoglobulin receptor binding IDA 23250751
genes like me logo Genes that share ontologies with IGHA2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHA2 Gene

Localization for IGHA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHA2 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0009897 external side of plasma membrane IBA --
GO:0070062 extracellular exosome IDA 23533145
GO:0071748 monomeric IgA immunoglobulin complex IDA 23250751
genes like me logo Genes that share ontologies with IGHA2: view

No data available for Subcellular locations from COMPARTMENTS for IGHA2 Gene

Pathways & Interactions for IGHA2 Gene

SuperPathways for IGHA2 Gene

No Data Available

Interacting Proteins for IGHA2 Gene

Selected Interacting proteins: P01877-IGHA2_HUMAN for IGHA2 Gene via IID

Gene Ontology (GO) - Biological Process for IGHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0003094 glomerular filtration IMP 23398317
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
genes like me logo Genes that share ontologies with IGHA2: view

No data available for Pathways by source and SIGNOR curated interactions for IGHA2 Gene

Drugs & Compounds for IGHA2 Gene

(1) Drugs for IGHA2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dansyllysine Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGHA2: view

Transcripts for IGHA2 Gene

mRNA/cDNA for IGHA2 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHA2 Gene

No ASD Table

Relevant External Links for IGHA2 Gene

GeneLoc Exon Structure for
IGHA2
ECgene alternative splicing isoforms for
IGHA2

Expression for IGHA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGHA2 Gene

mRNA differential expression in normal tissues according to GTEx for IGHA2 Gene

This gene is overexpressed in Colon - Transverse (x18.0), Small Intestine - Terminal Ileum (x16.7), and Minor Salivary Gland (x7.9).

Protein differential expression in normal tissues from HIPED for IGHA2 Gene

This gene is overexpressed in Milk (21.1), Synovial fluid (10.2), and Serum (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHA2 Gene



Protein tissue co-expression partners for IGHA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGHA2 Gene:

IGHA2
genes like me logo Genes that share expression patterns with IGHA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHA2 Gene

Orthologs for IGHA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Igha 35
  • 58 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 15 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 35
  • 13 (a)
OneToMany
Species where no ortholog for IGHA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHA2 Gene

ENSEMBL:
Gene Tree for IGHA2 (if available)
TreeFam:
Gene Tree for IGHA2 (if available)

Paralogs for IGHA2 Gene

Paralogs for IGHA2 Gene

genes like me logo Genes that share paralogs with IGHA2: view

Variants for IGHA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHA2 Gene

IGHA2_HUMAN-P01877
There are several alleles. The sequence shown is that of IMGT allele IGHA2*02.

Sequence variations from dbSNP and Humsavar for IGHA2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_003879 --
VAR_003880 --
VAR_003881 --
VAR_003882 --
VAR_003883 --

Relevant External Links for IGHA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHA2

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHA2 Gene

Disorders for IGHA2 Gene

Relevant External Links for IGHA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGHA2

No disorders were found for IGHA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGHA2 Gene

Publications for IGHA2 Gene

  1. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P. … Loo J.A. (J. Proteome Res. 2006) 3 4 64
  2. A proteomic analysis of human bile. (PMID: 15084671) Kristiansen T.Z. … Pandey A. (Mol. Cell. Proteomics 2004) 3 4 64
  3. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PMID: 14760718) Bunkenborg J. … Wisniewski J.R. (Proteomics 2004) 3 4 64
  4. The structure and function of human IgA. (PMID: 2241915) Kerr M.A. (Biochem. J. 1990) 3 4 64
  5. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. (PMID: 6421489) Flanagan J.G. … Rabbitts T.H. (Cell 1984) 3 4 64

Products for IGHA2 Gene

Sources for IGHA2 Gene

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