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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHA2 Gene

protein-coding   GIFtS: 39
GCID: GC14M106050

immunoglobulin heavy constant alpha 2 (A2m marker)
 Explore 2 diseases affiliated with
IGHA2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGHA2    

Aliases
for IGHA2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Heavy Constant Alpha 2 (A2m Marker)1 2

External Ids:    HGNC: 54791   Entrez Gene: 34942   Ensembl: ENSG000002118907   OMIM: 1470005   UniProtKB: P018773   

Export aliases for IGHA2 gene to outside databases

Previous GC identifers: GC14U990031 GC14M100045 GC14M104024 GC14M105124


Summaries
for IGHA2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: IGHA2_HUMAN, P01877
Function: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local
infection and to prevent access of foreign antigens to the general immunologic system

Gene Wiki entry for IGHA2


Genomic Views
for IGHA2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHA2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHA2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106050:  view genomic region     (about GC identifiers)

Start:
 106,053,226 bp from pter      End:
 106,054,732 bp from pter
Size:
 1,507 bases      Orientation:
 minus strand

Proteins
for IGHA2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IGHA2_HUMAN, P01877 (See protein sequence)
Recommended Name: Ig alpha-2 chain C region  
Size: 340 amino acids; 36526 Da
Subunit: Monomeric or polymeric
Miscellaneous: The sequence of the A2m(1) allotype is shown
Caution: N-glycosylation was reported in milk on the non-canonical Asn-92 site (PubMed:18780401). However, according to
Ref.10, N-glycosylation from the same tissue was found to be absent at this site
Sequence caution: Sequence=AAB59396.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for IGHA2: NX_P01877

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P01877

    • IGHA2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).


    ENSEMBL proteins: 
     ENSP00000374981  
    Reactome Protein details: P01877
    Human Recombinant Protein Products: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane NAS--


    IGHA2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for IGHA2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGHA2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01877

    ProtoNet protein and cluster: P01877

    1 Blocks protein family: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: IGHA2_HUMAN, P01877
    Similarity: Contains 3 Ig-like (immunoglobulin-like) domains


    Function
    for IGHA2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IGHA2_HUMAN, P01877
    Function: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local
    infection and to prevent access of foreign antigens to the general immunologic system

         Genatlas biochemistry entry for IGHA2:
    immunoglobulin,alpha 2 (A2M marker)

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    Inhib. RNA
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    Gene Editing
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS6421489


    IGHA2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for IGHA2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cleavage of Alpha-1-Microglobulin
    		Cleavage of Alpha-1-Microglobulin1.00
    		Binding and Uptake of Ligands by Scavenger Receptors0.79
    		Scavenging of Heme from Plasma0.79
    2Inflammatory Response Pathway
    		Inflammatory Response Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for IGHA2 
        Inflammatory Response Pathway

    3        Reactome Pathways for IGHA2
        Scavenging of Heme from Plasma
    Binding and Uptake of Ligands by Scavenger Receptors
    Cleavage of Alpha-1-Microglobulin



    IGHA2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for IGHA2 (P018773 ENSP000003749814) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUAK1O602853, ENSP000002614024I2D: score=1 STRING: ENSP00000261402
    CDK14O949213, ENSP000002657414I2D: score=1 STRING: ENSP00000265741
    CDK2AP1O145193, ENSP000002616924I2D: score=1 STRING: ENSP00000261692
    IGKCENSP000003747774STRING: ENSP00000374777
    PIGRENSP000003488884STRING: ENSP00000348888
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS2241915


    IGHA2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IGHA2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGHA2

    1 DrugBank Compound for IGHA2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DansyllysineDNS (see all 4)1101-84-4target--10592235

    Search CenterWatch for drugs/clinical trials and news about IGHA2 

    Transcripts
    for IGHA2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390539(uc001yrs.3 uc001yrt.3)

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    Browse OriGene siRNA
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    Primer
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      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHA2

    1 AceView cDNA sequence:

    AL389978 

    GeneLoc Exon Structure


    Expression
    for IGHA2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGHA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IGHA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGHA2
        SABiosciences Custom PCR Arrays for IGHA2
    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGHA2

    Orthologs
    for IGHA2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IGHA2 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 17(a)
    		 possible ortholog
    		 GL343491.1(485127-498368)
    zebrafish
    (Danio rerio)    		 Actinopterygii ighd6
    ighz6
    		 immunoglobulin heavy constant zeta
    		 4(a)
    12(a)
    		 many ↔ many
    many ↔ many
    		 3(34034542-34046885)
    3(34079980-34083059)


    ENSEMBL Gene Tree for IGHA2 (if available)
    TreeFam Gene Tree for IGHA2 (if available) 

    Paralogs
    for IGHA2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGHA2 gene
    IGHG22  IGHE2  IGHG32  IGHM2  IGHA12  IGHG42  IGHG12  
    18/19 SIMAP similar genes for IGHA2 using alignment to 1 protein entry:     IGHA2_HUMAN(see all similar genes):
    DKFZp686C02218    DKFZp686K04218    DKFZp686L19235    DKFZp686M08189    IGH@    DKFZp686C02220
    DKFZp686O16217    DKFZp686J11235    DKFZp686K18196    IGHA1    SNC73    DKFZp686G21220
    IGHG2    IGHG4    IGHG1    IGKC    IGHM    IGLC6

    IGHA2 for paralogs           About GeneDecksing



    Genomic Variants
    for IGHA2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHA2
    DNA2.0 Custom Variant and Variant Library Synthesis for IGHA2

    Disorders / Diseases
    for IGHA2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGHA2 for disorders           About GeneDecksing

    OMIM gene information: 147000    OMIM disorders: --

    2 diseases for IGHA2:    About MalaCards
    keratopathy    thalassemia

    1 disease from the University of Copenhagen DISEASES database for IGHA2:
    Thalassemia

    Export disorders for IGHA2 gene to outside databases

    Publications
    for IGHA2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGHA2 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with IGHA2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    2. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (2004)
    3. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)
    4. The structure and function of human IgA. (PubMed id 2241915)1, 2 Kerr M.A. (1990)
    5. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. (PubMed id 6421489)1, 2 Flanagan J.G.... Rabbitts T.H. (1984)
    6. Structure of the A2m(1) allotype of human IgA -- a recombinant molecule. (PubMed id 286295)1, 2 Tsuzukida Y.... Putnam F.W. (1979)
    7. Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the A2m (2) allotype. (PubMed id 416441)1, 2 Torano A. and Putnam F.W. (1978)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)

    External Searches for IGHA2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IGHA2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3494 HGNC: 5479 AceView: IGHA2 Ensembl:ENSG00000211890 euGenes: HUgn3494
    ECgene: IGHA2 H-InvDB: IGHA2

    Other Databases showing IGHA2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IGHA2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGHA2 Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGHA2 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHA2&species=Homo+sapiens

    Intellectual Property
    for IGHA2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGHA2 gene:
    Search GeneIP for patents involving IGHA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
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    von Willebrand factor
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