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Aliases for IGHA2 Gene

Aliases for IGHA2 Gene

  • Immunoglobulin Heavy Constant Alpha 2 (A2m Marker) 2 3

External Ids for IGHA2 Gene

Previous GeneCards Identifiers for IGHA2 Gene

  • GC14U990031
  • GC14M100045
  • GC14M104024
  • GC14M105124
  • GC14M106050

Summaries for IGHA2 Gene

GeneCards Summary for IGHA2 Gene

IGHA2 (Immunoglobulin Heavy Constant Alpha 2 (A2m Marker)) is a Protein Coding gene. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

UniProtKB/Swiss-Prot for IGHA2 Gene

  • Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system

Gene Wiki entry for IGHA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHA2 Gene

Genomics for IGHA2 Gene

Genomic Location for IGHA2 Gene

Start:
105,586,889 bp from pter
End:
105,588,395 bp from pter
Size:
1,507 bases
Orientation:
Minus strand

Genomic View for IGHA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGHA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHA2 Gene

No data available for Regulatory Elements for IGHA2 Gene

Proteins for IGHA2 Gene

  • Protein details for IGHA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01877-IGHA2_HUMAN
    Recommended name:
    Ig alpha-2 chain C region
    Protein Accession:
    P01877
    Secondary Accessions:

    Protein attributes for IGHA2 Gene

    Size:
    340 amino acids
    Molecular mass:
    36526 Da
    Quaternary structure:
    • Monomeric or polymeric
    Miscellaneous:
    • The sequence of the A2m(1) allotype is shown
    SequenceCaution:
    • Sequence=AAB59396.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHA2 Gene

neXtProt entry for IGHA2 Gene

Proteomics data for IGHA2 Gene at MOPED

Post-translational modifications for IGHA2 Gene

  • Glycosylation at Asn47, Asn131, Asn205, and Asn327
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHA2 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGHA2 Gene

Domains for IGHA2 Gene

Gene Families for IGHA2 Gene

HGNC:
  • IGH :Immunoglobulins / IGH locus

Protein Domains for IGHA2 Gene

Suggested Antigen Peptide Sequences for IGHA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01877

UniProtKB/Swiss-Prot:

IGHA2_HUMAN :
  • P01877
Domain:
  • Contains 3 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGHA2: view

Function for IGHA2 Gene

Molecular function for IGHA2 Gene

GENATLAS Biochemistry:
immunoglobulin,alpha 2 (A2M marker)
UniProtKB/Swiss-Prot Function:
Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system

Gene Ontology (GO) - Molecular Function for IGHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 6421489
GO:0005515 protein binding --
GO:0034987 contributes_to immunoglobulin receptor binding IDA 23250751
genes like me logo Genes that share ontologies with IGHA2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IGHA2 Gene

Localization for IGHA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGHA2 Gene COMPARTMENTS Subcellular localization image for IGHA2 gene
Compartment Confidence
extracellular 4
plasma membrane 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for IGHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 23533145
GO:0071748 monomeric IgA immunoglobulin complex IDA 23250751
GO:0071751 secretory IgA immunoglobulin complex IDA 23250751
genes like me logo Genes that share ontologies with IGHA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IGHA2 Gene

Pathways for IGHA2 Gene

genes like me logo Genes that share pathways with IGHA2: view

Pathways by source for IGHA2 Gene

1 BioSystems pathway for IGHA2 Gene

Interacting Proteins for IGHA2 Gene

Selected Interacting proteins: P01877-IGHA2_HUMAN for IGHA2 Gene via I2D

Gene Ontology (GO) - Biological Process for IGHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0003094 glomerular filtration IMP 23398317
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 2241915
GO:0019731 antibacterial humoral response IDA 23250751
genes like me logo Genes that share ontologies with IGHA2: view

Compounds for IGHA2 Gene

(1) Drugbank Compounds for IGHA2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dansyllysine
  • DNS
1101-84-4 target
genes like me logo Genes that share compounds with IGHA2: view

Transcripts for IGHA2 Gene

mRNA/cDNA for IGHA2 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHA2 Gene

No ASD Table

Relevant External Links for IGHA2 Gene

GeneLoc Exon Structure for
IGHA2
ECgene alternative splicing isoforms for
IGHA2

Expression for IGHA2 Gene

mRNA expression in normal human tissues for IGHA2 Gene

mRNA differential expression in normal tissues according to GTEx for IGHA2 Gene

This gene is overexpressed in Colon - Transverse (18.0), Small Intestine - Terminal Ileum (16.7), and Minor Salivary Gland (7.9).

Protein differential expression in normal tissues for IGHA2 Gene

This gene is overexpressed in Milk (21.1), Synovial fluid (10.2), and Serum (7.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGHA2 Gene

genes like me logo Genes that share expressions with IGHA2: view

Expression partners for IGHA2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHA2 Gene

Orthologs for IGHA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Igha 36
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 15 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 36
  • 13 (a)
OneToMany
Species with no ortholog for IGHA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHA2 Gene

ENSEMBL:
Gene Tree for IGHA2 (if available)
TreeFam:
Gene Tree for IGHA2 (if available)

Paralogs for IGHA2 Gene

Paralogs for IGHA2 Gene

genes like me logo Genes that share paralogs with IGHA2: view

Variants for IGHA2 Gene

Sequence variations from dbSNP and Humsavar for IGHA2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_003879 -
VAR_003880 -
VAR_003881 -
VAR_003882 -
VAR_003883 -

Relevant External Links for IGHA2 Gene

HapMap Linkage Disequilibrium report
IGHA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGHA2 Gene

Disorders for IGHA2 Gene

(1) University of Copenhagen DISEASES for IGHA2 Gene

genes like me logo Genes that share disorders with IGHA2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for IGHA2 Gene

Publications for IGHA2 Gene

  1. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P. … Loo J.A. (J. Proteome Res. 2006) 3 4
  2. Structure of the A2m(1) allotype of human IgA -- a recombinant molecule. (PMID: 286295) Tsuzukida Y. … Putnam F.W. (Proc. Natl. Acad. Sci. U.S.A. 1979) 3 4
  3. Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the A2m (2) allotype. (PMID: 416441) Torano A. … Putnam F.W. (Proc. Natl. Acad. Sci. U.S.A. 1978) 3 4
  4. The structure and function of human IgA. (PMID: 2241915) Kerr M.A. (Biochem. J. 1990) 3 4
  5. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. (PMID: 6421489) Flanagan J.G. … Rabbitts T.H. (Cell 1984) 3 4

Products for IGHA2 Gene

Sources for IGHA2 Gene

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