Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IGHA1 Gene

protein-coding   GIFtS: 45
GCID: GC14M106171

Immunoglobulin Heavy Constant Alpha 1

  See IGHA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Immunoglobulin Heavy Constant Alpha 11 2
IgA12

External Ids:    HGNC: 54781   Entrez Gene: 34932   Ensembl: ENSG000002118957   OMIM: 1469005   UniProtKB: P018763   

Export aliases for IGHA1 gene to outside databases

Previous GC identifers: GC14U990030 GC14M104147 GC14M104150 GC14M105249 GC14M105250 GC14M086307


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for IGHA1 Gene:
IGHA1 (immunoglobulin heavy constant alpha 1) is a protein-coding gene. Diseases associated with IGHA1 include breast adenocarcinoma, and hepatitis a. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.

UniProtKB/Swiss-Prot: IGHA1_HUMAN, P01876
Function: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local
infection and to prevent access of foreign antigens to the general immunologic system

Gene Wiki entry for IGHA1 (Immunoglobulin heavy constant alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Search for regulatory transcription factor binding sites for IGHA1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IGHA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGHA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

IGHA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106171:  view genomic region     (about GC identifiers)

Start:
106,173,457 bp from pter      End:
106,175,002 bp from pter
Size:
1,546 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IGHA1_HUMAN, P01876 (See protein sequence)
Recommended Name: Ig alpha-1 chain C region  
Size: 353 amino acids; 37655 Da
Subunit: Monomeric or polymeric
Sequence caution: Sequence=AAC82528.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for IGHA1:
1IGA (3D)        1OW0 (3D)        2QEJ (3D)        3CHN (3D)    

Explore the universe of human proteins at neXtProt for IGHA1: NX_P01876

Explore proteomics data for IGHA1 at MOPED

Post-translational modifications: 

  • 3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with
    alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore
    reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region
    Cys-3521
  • N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc41
  • Glycosylation2 at Ser105, Ser111, Ser113, Ser119, Ser121, Asn144, Asn340
  • Modification sites at PhosphoSitePlus

  • See IGHA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000374989  
    Reactome Protein details: P01876

    IGHA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IGHA1
    GenScript Custom Purified and Recombinant Proteins Services for IGHA1
    Novus Biologicals IGHA1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IGHA1 

     
    antibodies-online proteins for IGHA1 (3 products) 

     
    antibodies-online peptides for IGHA1

    IGHA1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IGHA1
    Novus Biologicals IGHA1 Antibodies
    Abcam antibodies for IGHA1 (P01877, P01876)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for IGHA1
    antibodies-online antibodies for IGHA1 (9 products) 

    IGHA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IGHA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IGHA1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for IGHA1 
    antibodies-online kits for IGHA1 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IGH: Immunoglobulins / IGH locus

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01876

    ProtoNet protein and cluster: P01876

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: IGHA1_HUMAN, P01876
    Similarity: Contains 3 Ig-like (immunoglobulin-like) domains


    Find genes that share domains with IGHA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IGHA1_HUMAN, P01876
    Function: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local
    infection and to prevent access of foreign antigens to the general immunologic system

         Genatlas biochemistry entry for IGHA1:
    immunoglobulin,alpha 1,including a locus control region,see LCR- IGHA1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding NAS107164
    GO:0005515protein binding ----
    GO:0034987contributes to immunoglobulin receptor binding IDA--
         
    Find genes that share ontologies with IGHA1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IGHA1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IGHA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IGHA1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse OriGene RNAi
    Predesigned siRNA for gene silencing in human, mouse, rat IGHA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IGHA1

    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGHA1
    Sino Biological Human cDNA Clone for IGHA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGHA1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IGHA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for IGHA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane2
    cytosol1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0070062extracellular vesicular exosome IDA--
    GO:0071748monomeric IgA immunoglobulin complex IDA--
    GO:0071751secretory IgA immunoglobulin complex IDA--

    Find genes that share ontologies with IGHA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IGHA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging of Heme from Plasma0.53
    2Regulation of nuclear SMAD2/3 signaling
    Regulation of nuclear SMAD2/3 signaling
    3Inflammatory Response Pathway
    Inflammatory Response Pathway


    Find genes that share SuperPaths with IGHA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for IGHA1
        Regulation of nuclear SMAD2/3 signaling
    Inflammatory Response Pathway


    1 Reactome Pathway for IGHA1
        Scavenging of heme from plasma


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGHA1
    Interactions:

        GeneGlobe Interaction Network for IGHA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IGHA1 (P018763 ENSP000003749894) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543, ENSP000002574304I2D: score=1 STRING: ENSP00000257430
    APOC1P026543, ENSP000002524914I2D: score=1 STRING: ENSP00000252491
    CAV1Q031353, ENSP000003391914I2D: score=1 STRING: ENSP00000339191
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    CTR9Q6PD623, ENSP000003550134I2D: score=1 STRING: ENSP00000355013
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001895retina homeostasis IEP--
    GO:0003094glomerular filtration IMP--
    GO:0006955immune response NAS107164
    GO:0018298protein-chromophore linkage IEA--
    GO:0019731antibacterial humoral response IDA--

    Find genes that share ontologies with IGHA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGHA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390547
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IGHA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IGHA1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse OriGene RNAi
    Predesigned siRNA for gene silencing in human, mouse, rat IGHA1
    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGHA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGHA1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHA1
    Primer
    Products:
        
    Browse OriGene qPCR
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IGHA1
      QuantiTect SYBR Green Assays in human, mouse, rat IGHA1
      QuantiFast Probe-based Assays in human, mouse, rat IGHA1

    9 AceView cDNA sequences:

    CR598487 CR606321 CR597203 CR608341 CR603781 AJ294729 AK128533 BX640822 
    AK123975 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IGHA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCCCAAG
    IGHA1 Expression
    About this image


    IGHA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Colon (Gastrointestinal Tract)
     
     Tonsil (Hematopoietic System)
    IGHA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGHA1 Protein Expression
        Custom PCR Arrays for IGHA1
    Primer
    Products:
    Browse OriGene qPCR
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IGHA1
    QuantiTect SYBR Green Assays in human, mouse, rat IGHA1
    QuantiFast Probe-based Assays in human, mouse, rat IGHA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for IGHA1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    16(a)
    many ↔ many
    GL343491.1(485127-498437)
    zebrafish
    (Danio rerio)
    Actinopterygii ighv1-46
    immunoglobulin heavy variable 1-4
    13(a)
    1 → many
    3(34048543-34145418) ENSDARG00000096355
            Species with no ortholog for IGHA1

    ENSEMBL Gene Tree for IGHA1 (if available)
    TreeFam Gene Tree for IGHA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IGHA1 gene
    IGHG22  IGHE2  IGHM2  IGHG32  IGHG42  IGHG12  IGHA22  
    Selected SIMAP similar genes for IGHA1 using alignment to 1 protein entry:     IGHA1_HUMAN(see all similar genes):
    DKFZp686G21220    DKFZp686J11235    DKFZp686K18196    SNC73    DKFZp686C02218    DKFZp686K04218
    DKFZp686L19235    IGHA2    DKFZp686C02220    DKFZp686M08189    DKFZp686O16217    IGH@
    DKFZp686E23209    DKFZp686M24218    IGHG2    IGHG4    DKFZp686C11235    DKFZp686C15213

    Find genes that share paralogs with IGHA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    1 SNPs for IGHA1    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs14071,2,4
    ----see VAR_0146022 mis40--------

    HapMap Linkage Disequilibrium report for IGHA1 (106173457 - 106175002 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IGHA1: --
    Human Gene Mutation Database (HGMD): IGHA1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGHA1
    DNA2.0 Custom Variant and Variant Library Synthesis for IGHA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 146900    OMIM disorders: --

    UniProtKB/Swiss-Prot: IGHA1_HUMAN, P01876
  • Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation
    t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein

  • 2 diseases for IGHA1:    
    About MalaCards
    breast adenocarcinoma    hepatitis a


    Find genes that share disorders with IGHA1           About GenesLikeMe

    Genetic Association Database (GAD): IGHA1
    Human Genome Epidemiology (HuGE) Navigator: IGHA1 (1 document)

    Export disorders for IGHA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IGHA1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with IGHA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration. (PubMed id 20007591)1, 4 Giambra V....Frezza D. (J. Immunol. 2009)
    2. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (Mol. Cell. Proteomics 2004)
    3. Location of a novel type of interpolypeptide chain linkage in the human protein HC-IgA complex (HC-IgA) and identification of a heterogeneous chromophore associated with the complex. (PubMed id 7506257)1, 2 Calero M.... Mendez E. (J. Biol. Chem. 1994)
    4. The structure and function of human IgA. (PubMed id 2241915)1, 2 Kerr M.A. (Biochem. J. 1990)
    5. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. (PubMed id 6421489)1, 2 Flanagan J.G.... Rabbitts T.H. (Cell 1984)
    6. Rule of antibody structure. Primary structure of a human monoclonal IgA-immunoglobulin (myeloma protein Tro). VII. Purification and characterization of the disulfide bridges. (PubMed id 393607)1, 2 Yang C.-Y.... Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1979)
    7. Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain. (PubMed id 107164)1, 2 Putnam F.W.... Low T.L.K. (J. Biol. Chem. 1979)
    8. The primary structure of a monoclonal IgA-immunoglobulin (IgA Tro.), II. The amino acid sequence of the H-chain, alpha-type, subgroup III; structure of the complete IgA-molecule. (PubMed id 809331)1, 2 Kratzin H....Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1975)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. (PubMed id 23077236)1 Vigodner M....Callaway M. (Hum. Reprod. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3493 HGNC: 5478 AceView: IGHA1 Ensembl:ENSG00000211895 euGenes: HUgn3493
    ECgene: IGHA1 H-InvDB: IGHA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IGHA1 Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGHA1 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHA1&species=Homo+sapiens

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IGHA1 gene:
    Search GeneIP for patents involving IGHA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   Browse OriGene RNAi products  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   Browse OriGene clones  
     Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IGHA1   OriGene Custom Protein Services for IGHA1  

     
     
     Block miRNA regulation of human, mouse, rat IGHA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IGHA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGHA1 Predesigned siRNA for gene silencing in human, mouse, rat IGHA1
     QuantiFast Probe-based Assays in human, mouse, rat IGHA1 QuantiTect SYBR Green Assays in human, mouse, rat IGHA1
     Custom PCR Arrays for IGHA1 Search Chromatin IP Primers for IGHA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IGHA1  GeneGlobe Interaction Network for IGHA1
     Search Regulatory tfbs for IGHA1
     GenScript Custom Purified and Recombinant Proteins Services for IGHA1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for IGHA1
     GenScript Custom Assay Services for IGHA1 GenScript Custom overexpressing Cell Line Services for IGHA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IGHA1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for IGHA1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IGHA1 antibodies
     IGHA1 proteins
     Antibodies for IGHA1
     See all of Abcam's Antibodies, Kits and Proteins for IGHA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for IGHA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHA1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IGHA1
     Browse SwitchGear Promoter luciferase reporter plasmids for IGHA1
     ThermoFisher Antibodies for IGHA1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHA1
     Browse compounds at ApexBio
     Search Addgene for plasmids for IGHA1
      Search eBioscience for proteins for IGHA1
      Search eBioscience for elisas for IGHA1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for IGHA1
     antibodies-online antibodies for IGHA1 (9 products)
     antibodies-online kits for IGHA1 (2 products)
     antibodies-online peptides for IGHA1
     antibodies-online proteins for IGHA1 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IGHA1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4