Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGHA1 Gene

Aliases for IGHA1 Gene

  • Immunoglobulin Heavy Constant Alpha 1 2 3
  • Immunoglobulin Heavy Chain Constant Region Alpha 1 3
  • Immunoglobulin Alpha 1 3
  • IgA1 3

External Ids for IGHA1 Gene

Previous GeneCards Identifiers for IGHA1 Gene

  • GC14U990030
  • GC14M104147
  • GC14M104150
  • GC14M105249
  • GC14M105250
  • GC14M106171
  • GC14M086307

Summaries for IGHA1 Gene

GeneCards Summary for IGHA1 Gene

IGHA1 (Immunoglobulin Heavy Constant Alpha 1) is a Protein Coding gene. Diseases associated with IGHA1 include breast adenocarcinoma and hepatitis a. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

UniProtKB/Swiss-Prot for IGHA1 Gene

  • Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system

Gene Wiki entry for IGHA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHA1 Gene

Genomics for IGHA1 Gene

Genomic Location for IGHA1 Gene

Start:
105,707,118 bp from pter
End:
105,708,665 bp from pter
Size:
1,548 bases
Orientation:
Minus strand

Genomic View for IGHA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGHA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHA1 Gene

No data available for Regulatory Elements for IGHA1 Gene

Proteins for IGHA1 Gene

  • Protein details for IGHA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01876-IGHA1_HUMAN
    Recommended name:
    Ig alpha-1 chain C region
    Protein Accession:
    P01876
    Secondary Accessions:

    Protein attributes for IGHA1 Gene

    Size:
    353 amino acids
    Molecular mass:
    37655 Da
    Quaternary structure:
    • Monomeric or polymeric
    SequenceCaution:
    • Sequence=AAC82528.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHA1 Gene

neXtProt entry for IGHA1 Gene

Proteomics data for IGHA1 Gene at MOPED

Post-translational modifications for IGHA1 Gene

  • 3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352
  • N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4.
  • Glycosylation at Ser105, Ser111, Ser113, Ser119, Ser121, Asn144, and Asn340
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHA1 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGHA1 Gene

Domains for IGHA1 Gene

Gene Families for IGHA1 Gene

HGNC:
  • IGH :Immunoglobulins / IGH locus

Protein Domains for IGHA1 Gene

Suggested Antigen Peptide Sequences for IGHA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01876

UniProtKB/Swiss-Prot:

IGHA1_HUMAN :
  • P01876
Domain:
  • Contains 3 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGHA1: view

Function for IGHA1 Gene

Molecular function for IGHA1 Gene

GENATLAS Biochemistry: immunoglobulin,alpha 1,including a locus control region,see LCR- IGHA1
UniProtKB/Swiss-Prot Function: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system

Gene Ontology (GO) - Molecular Function for IGHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 107164
GO:0005515 protein binding --
GO:0034987 contributes_to immunoglobulin receptor binding IDA 23250751
genes like me logo Genes that share ontologies with IGHA1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IGHA1 Gene

Localization for IGHA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGHA1 Gene COMPARTMENTS Subcellular localization image for IGHA1 gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 20458337
GO:0071748 monomeric IgA immunoglobulin complex IDA 23250751
GO:0071751 secretory IgA immunoglobulin complex IDA 23250751
genes like me logo Genes that share ontologies with IGHA1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IGHA1 Gene

Pathways for IGHA1 Gene

genes like me logo Genes that share pathways with IGHA1: view

Pathways by source for IGHA1 Gene

Interacting Proteins for IGHA1 Gene

Selected Interacting proteins: P01876-IGHA1_HUMAN for IGHA1 Gene via I2D

Gene Ontology (GO) - Biological Process for IGHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0003094 glomerular filtration IMP 23398317
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 107164
GO:0018298 protein-chromophore linkage IEA --
genes like me logo Genes that share ontologies with IGHA1: view

Transcripts for IGHA1 Gene

mRNA/cDNA for IGHA1 Gene

(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHA1 Gene

No ASD Table

Relevant External Links for IGHA1 Gene

GeneLoc Exon Structure for
IGHA1
ECgene alternative splicing isoforms for
IGHA1

Expression for IGHA1 Gene

mRNA expression in normal human tissues for IGHA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGHA1 Gene

This gene is overexpressed in Minor Salivary Gland (13.2), Colon - Transverse (8.8), Spleen (7.5), Small Intestine - Terminal Ileum (7.4), and Stomach (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGHA1 Gene

genes like me logo Genes that share expressions with IGHA1: view

No data available for mRNA Expression by UniProt/SwissProt for IGHA1 Gene

Orthologs for IGHA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 54 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Igha 36
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 16 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 36
  • 13 (a)
OneToMany
Species with no ortholog for IGHA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHA1 Gene

ENSEMBL:
Gene Tree for IGHA1 (if available)
TreeFam:
Gene Tree for IGHA1 (if available)

Paralogs for IGHA1 Gene

Paralogs for IGHA1 Gene

genes like me logo Genes that share paralogs with IGHA1: view

Variants for IGHA1 Gene

Sequence variations from dbSNP and Humsavar for IGHA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_014602 -

Relevant External Links for IGHA1 Gene

HapMap Linkage Disequilibrium report
IGHA1
Human Gene Mutation Database (HGMD)
IGHA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGHA1 Gene

Disorders for IGHA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for IGHA1 Gene including...

Search for IGHA1 Gene in MalaCards »

UniProtKB/Swiss-Prot

IGHA1_HUMAN
  • Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Relevant External Links for IGHA1

Genetic Association Database (GAD)
IGHA1
Human Genome Epidemiology (HuGE) Navigator
IGHA1
genes like me logo Genes that share disorders with IGHA1: view

Publications for IGHA1 Gene

  1. Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain. (PMID: 107164) Putnam F.W. … Low T.L.K. (J. Biol. Chem. 1979) 3 4
  2. Rule of antibody structure. Primary structure of a human monoclonal IgA-immunoglobulin (myeloma protein Tro). VII. Purification and characterization of the disulfide bridges. (PMID: 393607) Yang C.-Y. … Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1979) 3 4
  3. The primary structure of a monoclonal IgA-immunoglobulin (IgA Tro.), II. The amino acid sequence of the H-chain, alpha-type, subgroup III; structure of the complete IgA-molecule. (PMID: 809331) Kratzin H. … Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1975) 3 4
  4. The structure and function of human IgA. (PMID: 2241915) Kerr M.A. (Biochem. J. 1990) 3 4
  5. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. (PMID: 6421489) Flanagan J.G. … Rabbitts T.H. (Cell 1984) 3 4

Products for IGHA1 Gene

Sources for IGHA1 Gene

Back to Top

Content