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Aliases for IGHA1 Gene

Aliases for IGHA1 Gene

  • Immunoglobulin Heavy Constant Alpha 1 2 3
  • Immunoglobulin Heavy Chain Constant Region Alpha 1 3
  • Immunoglobulin Alpha 1 3
  • IgA1 3

External Ids for IGHA1 Gene

Previous GeneCards Identifiers for IGHA1 Gene

  • GC14U990030
  • GC14M104147
  • GC14M104150
  • GC14M105249
  • GC14M105250
  • GC14M106171
  • GC14M086307

Summaries for IGHA1 Gene

GeneCards Summary for IGHA1 Gene

IGHA1 (Immunoglobulin Heavy Constant Alpha 1) is a Protein Coding gene. Diseases associated with IGHA1 include pseudotumor cerebri. Among its related pathways are Vesicle-mediated transport and Regulation of nuclear SMAD2/3 signaling. GO annotations related to this gene include antigen binding and immunoglobulin receptor binding. An important paralog of this gene is IGHG4.

UniProtKB/Swiss-Prot for IGHA1 Gene

  • Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system

Gene Wiki entry for IGHA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHA1 Gene

Genomics for IGHA1 Gene

Genomic Location for IGHA1 Gene

Chromosome:
14
Start:
105,707,118 bp from pter
End:
105,708,665 bp from pter
Size:
1,548 bases
Orientation:
Minus strand

Genomic View for IGHA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for IGHA1 Gene

No data available for Regulatory Elements for IGHA1 Gene

Proteins for IGHA1 Gene

  • Protein details for IGHA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01876-IGHA1_HUMAN
    Recommended name:
    Ig alpha-1 chain C region
    Protein Accession:
    P01876

    Protein attributes for IGHA1 Gene

    Size:
    353 amino acids
    Molecular mass:
    37655 Da
    Quaternary structure:
    • Monomeric or polymeric
    SequenceCaution:
    • Sequence=AAC82528.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHA1 Gene

neXtProt entry for IGHA1 Gene

Proteomics data for IGHA1 Gene at MOPED

Post-translational modifications for IGHA1 Gene

  • 3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352
  • N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4.
  • Glycosylation at Ser 105, Ser 111, Ser 113, Ser 119, Ser 121, Asn 144, and Asn 340
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHA1 Gene

ENSEMBL proteins:

Antibody Products

No data available for DME Specific Peptides for IGHA1 Gene

Domains & Families for IGHA1 Gene

Gene Families for IGHA1 Gene

Protein Domains for IGHA1 Gene

Suggested Antigen Peptide Sequences for IGHA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01876

UniProtKB/Swiss-Prot:

IGHA1_HUMAN :
  • Contains 3 Ig-like (immunoglobulin-like) domains.
Domain:
  • Contains 3 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGHA1: view

Function for IGHA1 Gene

Molecular function for IGHA1 Gene

GENATLAS Biochemistry:
immunoglobulin,alpha 1,including a locus control region,see LCR- IGHA1
UniProtKB/Swiss-Prot Function:
Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system

Gene Ontology (GO) - Molecular Function for IGHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 107164
GO:0034987 contributes_to immunoglobulin receptor binding IDA 23250751
genes like me logo Genes that share ontologies with IGHA1: view

Phenotypes for IGHA1 Gene

GenomeRNAi human phenotypes for IGHA1:
genes like me logo Genes that share phenotypes with IGHA1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHA1 Gene

Localization for IGHA1 Gene

Gene Ontology (GO) - Cellular Components for IGHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0009897 external side of plasma membrane IBA --
GO:0070062 extracellular exosome IDA 20458337
GO:0071748 monomeric IgA immunoglobulin complex IDA 23250751
genes like me logo Genes that share ontologies with IGHA1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGHA1 Gene

Pathways & Interactions for IGHA1 Gene

genes like me logo Genes that share pathways with IGHA1: view

Interacting Proteins for IGHA1 Gene

Selected Interacting proteins: P01876-IGHA1_HUMAN for IGHA1 Gene via I2D

Gene Ontology (GO) - Biological Process for IGHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0003094 glomerular filtration IMP 23398317
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
genes like me logo Genes that share ontologies with IGHA1: view

No data available for SIGNOR curated interactions for IGHA1 Gene

Drugs & Compounds for IGHA1 Gene

No Compound Related Data Available

Transcripts for IGHA1 Gene

mRNA/cDNA for IGHA1 Gene

(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHA1 Gene

No ASD Table

Relevant External Links for IGHA1 Gene

GeneLoc Exon Structure for
IGHA1
ECgene alternative splicing isoforms for
IGHA1

Expression for IGHA1 Gene

mRNA expression in normal human tissues for IGHA1 Gene

mRNA differential expression in normal tissues according to GTEx for IGHA1 Gene

This gene is overexpressed in Minor Salivary Gland (x13.2), Colon - Transverse (x8.8), Spleen (x7.5), Small Intestine - Terminal Ileum (x7.4), and Stomach (x4.2).

Protein differential expression in normal tissues from HIPED for IGHA1 Gene

This gene is overexpressed in Milk (9.6), Pancreatic juice (7.4), and Serum (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHA1 Gene



genes like me logo Genes that share expression patterns with IGHA1: view

Protein tissue co-expression partners for IGHA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHA1 Gene

Orthologs for IGHA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Igha 36
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 16 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ighv1-4 36
  • 13 (a)
OneToMany
Species with no ortholog for IGHA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHA1 Gene

ENSEMBL:
Gene Tree for IGHA1 (if available)
TreeFam:
Gene Tree for IGHA1 (if available)

Paralogs for IGHA1 Gene

Paralogs for IGHA1 Gene

genes like me logo Genes that share paralogs with IGHA1: view

Variants for IGHA1 Gene

Sequence variations from dbSNP and Humsavar for IGHA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_014602 -

Relevant External Links for IGHA1 Gene

HapMap Linkage Disequilibrium report
IGHA1
Human Gene Mutation Database (HGMD)
IGHA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHA1 Gene

Disorders for IGHA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGHA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pseudotumor cerebri
  • idiopathic intracranial hypertension
- elite association
Search IGHA1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IGHA1_HUMAN
  • Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Relevant External Links for IGHA1

Genetic Association Database (GAD)
IGHA1
Human Genome Epidemiology (HuGE) Navigator
IGHA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGHA1
genes like me logo Genes that share disorders with IGHA1: view

No data available for Genatlas for IGHA1 Gene

Publications for IGHA1 Gene

  1. Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. (PMID: 17229699) Tami C. … Kaplan G.G. (J. Virol. 2007) 23 67
  2. Characterization of the horse (Equus caballus) IGHA gene. (PMID: 14564492) Wagner B. … Antczak D.F. (Immunogenetics 2003) 23 67
  3. New allele variants of the immunoglobulin switch (Salpha) regions. (PMID: 8655157) Keyeux G. … Bernal J.E. (Hum. Genet. 1996) 23 67
  4. Current Understanding of the Role of Complement in IgA Nephropathy. (PMID: 25694468) Maillard N. … Novak J. (J. Am. Soc. Nephrol. 2015) 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for IGHA1 Gene

Sources for IGHA1 Gene

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