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Aliases for IGHA1 Gene

Aliases for IGHA1 Gene

  • Immunoglobulin Heavy Constant Alpha 1 2 3 5
  • Immunoglobulin Heavy Chain Constant Region Alpha 1 3
  • Immunoglobulin Alpha 1 3
  • IgA1 3

External Ids for IGHA1 Gene

Previous GeneCards Identifiers for IGHA1 Gene

  • GC14U990030
  • GC14M104147
  • GC14M104150
  • GC14M105249
  • GC14M105250
  • GC14M106171
  • GC14M086307
  • GC14M105708

Summaries for IGHA1 Gene

GeneCards Summary for IGHA1 Gene

IGHA1 (Immunoglobulin Heavy Constant Alpha 1) is a Protein Coding gene. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and Vesicle-mediated transport. GO annotations related to this gene include antigen binding and immunoglobulin receptor binding. An important paralog of this gene is IGHA2.

UniProtKB/Swiss-Prot for IGHA1 Gene

  • Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.

Gene Wiki entry for IGHA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHA1 Gene

Genomics for IGHA1 Gene

Regulatory Elements for IGHA1 Gene

Enhancers for IGHA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F105698 1.5 FANTOM5 Ensembl ENCODE 0.8 +3.8 3808 12.9 HDGF TBP PKNOX1 YBX1 BMI1 ZNF366 SCRT2 ZNF143 ZNF207 FOS ENSG00000257270 LINC00638 TMEM121 IGHV3-64 IGHE IGHV3-20 IGHV3-15 IGHA1 ENSG00000253701
GH14F105711 0.6 ENCODE 0.8 -3.4 -3411 1.0 HDGF NONO POLR2A ZBTB8A ZNF592 IGHA1 IGHEP1
GH14F105712 0.2 ENCODE 0.8 -4.2 -4214 0.2 IGHE IGHA1 IGHEP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGHA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHA1 Gene

105,707,118 bp from pter
105,708,665 bp from pter
1,548 bases
Minus strand

Genomic View for IGHA1 Gene

Genes around IGHA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHA1 Gene

Proteins for IGHA1 Gene

  • Protein details for IGHA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ig alpha-1 chain C region
    Protein Accession:

    Protein attributes for IGHA1 Gene

    353 amino acids
    Molecular mass:
    37655 Da
    Quaternary structure:
    • Monomeric or polymeric.
    • Sequence=AAC82528.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHA1 Gene

neXtProt entry for IGHA1 Gene

Post-translational modifications for IGHA1 Gene

  • 3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.
  • N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4.
  • Glycosylation at Ser 105, Ser 111, Ser 113, Ser 119, Ser 121, Asn 144, and Asn 340
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHA1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHA1 Gene

Domains & Families for IGHA1 Gene

Gene Families for IGHA1 Gene

Protein Domains for IGHA1 Gene

Suggested Antigen Peptide Sequences for IGHA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like (immunoglobulin-like) domains.
  • Contains 3 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGHA1: view

Function for IGHA1 Gene

Molecular function for IGHA1 Gene

GENATLAS Biochemistry:
immunoglobulin,alpha 1,including a locus control region,see LCR- IGHA1
UniProtKB/Swiss-Prot Function:
Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.

Gene Ontology (GO) - Molecular Function for IGHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS,IBA 107164
GO:0034987 contributes_to immunoglobulin receptor binding IDA 23250751
genes like me logo Genes that share ontologies with IGHA1: view

Phenotypes for IGHA1 Gene

GenomeRNAi human phenotypes for IGHA1:
genes like me logo Genes that share phenotypes with IGHA1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHA1 Gene

Localization for IGHA1 Gene

Gene Ontology (GO) - Cellular Components for IGHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0009897 external side of plasma membrane IBA --
GO:0070062 extracellular exosome IDA 20458337
GO:0071748 monomeric IgA immunoglobulin complex IDA 23250751
genes like me logo Genes that share ontologies with IGHA1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGHA1 Gene

Pathways & Interactions for IGHA1 Gene

genes like me logo Genes that share pathways with IGHA1: view

Interacting Proteins for IGHA1 Gene

Selected Interacting proteins: P01876-IGHA1_HUMAN for IGHA1 Gene via IID

Gene Ontology (GO) - Biological Process for IGHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0003094 glomerular filtration IMP 23398317
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
genes like me logo Genes that share ontologies with IGHA1: view

No data available for SIGNOR curated interactions for IGHA1 Gene

Transcripts for IGHA1 Gene

mRNA/cDNA for IGHA1 Gene

(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHA1 Gene

No ASD Table

Relevant External Links for IGHA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGHA1 Gene

mRNA differential expression in normal tissues according to GTEx for IGHA1 Gene

This gene is overexpressed in Minor Salivary Gland (x13.2), Colon - Transverse (x8.8), Spleen (x7.5), Small Intestine - Terminal Ileum (x7.4), and Stomach (x4.2).

Protein differential expression in normal tissues from HIPED for IGHA1 Gene

This gene is overexpressed in Milk (9.6), Pancreatic juice (7.4), and Serum (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHA1 Gene

Protein tissue co-expression partners for IGHA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGHA1 Gene:

genes like me logo Genes that share expression patterns with IGHA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHA1 Gene

Orthologs for IGHA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 35
  • 62 (a)
(Mus musculus)
Mammalia Igha 35
  • 58 (a)
(Canis familiaris)
Mammalia -- 35
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 16 (a)
(Danio rerio)
Actinopterygii ighv1-4 35
  • 13 (a)
Species where no ortholog for IGHA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHA1 Gene

Gene Tree for IGHA1 (if available)
Gene Tree for IGHA1 (if available)

Paralogs for IGHA1 Gene

Variants for IGHA1 Gene

Sequence variations from dbSNP and Humsavar for IGHA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1407 --

Relevant External Links for IGHA1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHA1 Gene

Disorders for IGHA1 Gene


  • Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. {ECO:0000269 PubMed:11290337}.

Relevant External Links for IGHA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGHA1 Gene.

No data available for MalaCards and Genatlas for IGHA1 Gene

Publications for IGHA1 Gene

  1. Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration. (PMID: 20007591) Giambra V. … Frezza D. (J. Immunol. 2009) 3 46 64
  2. A proteomic analysis of human bile. (PMID: 15084671) Kristiansen T.Z. … Pandey A. (Mol. Cell. Proteomics 2004) 3 4 64
  3. Location of a novel type of interpolypeptide chain linkage in the human protein HC-IgA complex (HC-IgA) and identification of a heterogeneous chromophore associated with the complex. (PMID: 7506257) Calero M. … Mendez E. (J. Biol. Chem. 1994) 3 4 64
  4. The structure and function of human IgA. (PMID: 2241915) Kerr M.A. (Biochem. J. 1990) 3 4 64
  5. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. (PMID: 6421489) Flanagan J.G. … Rabbitts T.H. (Cell 1984) 3 4 64

Products for IGHA1 Gene

Sources for IGHA1 Gene

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