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Aliases for IGHA1 Gene

Aliases for IGHA1 Gene

  • Immunoglobulin Heavy Constant Alpha 1 2 3 5
  • Immunoglobulin Heavy Chain Constant Region Alpha 1 3
  • Immunoglobulin Alpha 1 3
  • IgA1 3

External Ids for IGHA1 Gene

Previous GeneCards Identifiers for IGHA1 Gene

  • GC14U990030
  • GC14M104147
  • GC14M104150
  • GC14M105249
  • GC14M105250
  • GC14M106171
  • GC14M086307
  • GC14M105708

Summaries for IGHA1 Gene

GeneCards Summary for IGHA1 Gene

IGHA1 (Immunoglobulin Heavy Constant Alpha 1) is a Protein Coding gene. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Inflammatory Response Pathway. GO annotations related to this gene include antigen binding and immunoglobulin receptor binding. An important paralog of this gene is IGHG4.

UniProtKB/Swiss-Prot for IGHA1 Gene

  • Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.

Gene Wiki entry for IGHA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHA1 Gene

Genomics for IGHA1 Gene

Regulatory Elements for IGHA1 Gene

Enhancers for IGHA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IGHA1 on UCSC Golden Path with GeneCards custom track

Promoters for IGHA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IGHA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGHA1 Gene

105,707,118 bp from pter
105,708,665 bp from pter
1,548 bases
Minus strand

Genomic View for IGHA1 Gene

Genes around IGHA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHA1 Gene

Proteins for IGHA1 Gene

  • Protein details for IGHA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ig alpha-1 chain C region
    Protein Accession:

    Protein attributes for IGHA1 Gene

    353 amino acids
    Molecular mass:
    37655 Da
    Quaternary structure:
    • Monomeric or polymeric.
    • Sequence=AAC82528.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHA1 Gene

neXtProt entry for IGHA1 Gene

Proteomics data for IGHA1 Gene at MOPED

Post-translational modifications for IGHA1 Gene

  • 3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.
  • N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4.
  • Glycosylation at Ser 105, Ser 111, Ser 113, Ser 119, Ser 121, Asn 144, and Asn 340
  • Modification sites at PhosphoSitePlus

Other Protein References for IGHA1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHA1 Gene

Domains & Families for IGHA1 Gene

Gene Families for IGHA1 Gene

Protein Domains for IGHA1 Gene

Suggested Antigen Peptide Sequences for IGHA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like (immunoglobulin-like) domains.
  • Contains 3 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGHA1: view

Function for IGHA1 Gene

Molecular function for IGHA1 Gene

GENATLAS Biochemistry:
immunoglobulin,alpha 1,including a locus control region,see LCR- IGHA1
UniProtKB/Swiss-Prot Function:
Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.

Phenotypes for IGHA1 Gene

GenomeRNAi human phenotypes for IGHA1:
genes like me logo Genes that share phenotypes with IGHA1: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHA1 Gene

Localization for IGHA1 Gene

Gene Ontology (GO) - Cellular Components for IGHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
GO:0071752 secretory dimeric IgA immunoglobulin complex IDA 24145934
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGHA1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGHA1 Gene

Pathways & Interactions for IGHA1 Gene

genes like me logo Genes that share pathways with IGHA1: view

Interacting Proteins for IGHA1 Gene

Selected Interacting proteins: P01876-IGHA1_HUMAN for IGHA1 Gene via I2D

Gene Ontology (GO) - Biological Process for IGHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003094 glomerular filtration IMP 23398317
GO:0006911 phagocytosis, engulfment IBA --
GO:0006955 immune response NAS 107164
GO:0018298 protein-chromophore linkage IEA --
GO:0019731 antibacterial humoral response IDA 23250751
genes like me logo Genes that share ontologies with IGHA1: view

No data available for SIGNOR curated interactions for IGHA1 Gene

Drugs & Compounds for IGHA1 Gene

No Compound Related Data Available

Transcripts for IGHA1 Gene

mRNA/cDNA for IGHA1 Gene

(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHA1 Gene

No ASD Table

Relevant External Links for IGHA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGHA1 Gene

mRNA expression in normal human tissues for IGHA1 Gene

mRNA differential expression in normal tissues according to GTEx for IGHA1 Gene

This gene is overexpressed in Minor Salivary Gland (x13.2), Colon - Transverse (x8.8), Spleen (x7.5), Small Intestine - Terminal Ileum (x7.4), and Stomach (x4.2).

Protein differential expression in normal tissues from HIPED for IGHA1 Gene

This gene is overexpressed in Milk (9.6), Pancreatic juice (7.4), and Serum (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHA1 Gene

genes like me logo Genes that share expression patterns with IGHA1: view

Protein tissue co-expression partners for IGHA1 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGHA1 Gene

Orthologs for IGHA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
(Canis familiaris)
Mammalia -- 36
  • 54 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
(Mus musculus)
Mammalia Igha 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 16 (a)
(Danio rerio)
Actinopterygii ighv1-4 36
  • 13 (a)
Species with no ortholog for IGHA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGHA1 Gene

Gene Tree for IGHA1 (if available)
Gene Tree for IGHA1 (if available)

Paralogs for IGHA1 Gene

Paralogs for IGHA1 Gene

genes like me logo Genes that share paralogs with IGHA1: view

Variants for IGHA1 Gene

Sequence variations from dbSNP and Humsavar for IGHA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_014602 -

Relevant External Links for IGHA1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHA1 Gene

Disorders for IGHA1 Gene


  • Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. {ECO:0000269 PubMed:11290337}.

Relevant External Links for IGHA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGHA1 Gene.

No data available for MalaCards and Genatlas for IGHA1 Gene

Publications for IGHA1 Gene

  1. Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration. (PMID: 20007591) Giambra V. … Frezza D. (J. Immunol. 2009) 3 48 67
  2. DNA methylation in Cosmc promoter region and aberrantly glycosylated IgA1 associated with pediatric IgA nephropathy. (PMID: 25647400) Sun Q. … Shen Y. (PLoS ONE 2015) 3
  3. Current Understanding of the Role of Complement in IgA Nephropathy. (PMID: 25694468) Maillard N. … Novak J. (J. Am. Soc. Nephrol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for IGHA1 Gene

Sources for IGHA1 Gene