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IGH@ Gene

gene cluster   GIFtS: 40

GC14M105646
immunoglobulin heavy locus
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IGHDY1)
Services    

Aliases &
Descriptions
for IGH@

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
DKFZp686C15213 2
IGH 1, 2
IGH.1@ 2
IGHDY1 2
MGC72071 2
MGC88774 2
Descriptions
immunoglobulin heavy locus 2
External Ids
HGNC: 54771
Entrez Gene: 34922
UniProtKB: A2J1N24
Ensembl: ENSG000002119417
Search outside databases for aliases for IGH@ gene

Previous GC identifers: GC14U990029 GC00U921694 GC14M105276

Summaries
for IGH@

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for IGH@:
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and
the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two
identical light chains. This region represents the germline organization of the heavy chain locus.
The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B
cell development, a recombination event at the DNA level joins a single D segment with a J
segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is
then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in
development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to
encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch
recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE
genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of
many different V segments with several J segments provides a wide range of antigen recognition.
Additional diversity is attained by junctional diversity, resulting from the random additional of
nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs
during B cell maturation in the spleen and lymph nodes. Several V, D, J, and C segments are known
to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq]

Gene Wiki entry for IGH@

Genomic Location
for IGH@

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.32-q32.33

IGH@ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M105646:     (about GC identifiers)

Start:
 105,644,276 bp from pter
End:
 105,644,725 bp from pter
Size:
 450 bases
Orientation:
 minus strand

Proteins
for IGH@

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/TrEMBL: A2J1N2 (See protein sequence)
Recommended Name: Rheumatoid factor RF-IP18  
Size: 98 amino acids; 10737 Da



ENSEMBL proteins: 
ENSP00000375010 


Human Recombinant Proteins 
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                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for IGH@: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for IGH@

Assays for IGH@: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
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Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for IGH@

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro domains/families:
 IPR007110 Ig-like
 IPR003596 Ig_V-set_sub
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set


   GeneDecks  IGH@ for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry A2J1N2

ProtoNet protein and cluster: A2J1N2

Gene Function
for IGH@

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for IGH@

              Browse siRNA at Sigma-Aldrich  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for IGH@
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                Browse Origene genome-wide validated SYBR primer pairs

Pathways & Interactions
for IGH@

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


5/7 Millipore Pathways for IGH@ (see all 7 )
 Immune response Classic complement pathway
 Immune response BCR pathway
 Immune response CD16 signaling in NK cells
 Signal transduction IP3 signaling
 Immune response IL-4 signaling pathway

   GeneDecks  IGH@ for the pathways selected above  
About GeneDecksing

 Gene Network CentralTM Interacting Genes and Proteins Network for  IGH@ 

  --

Drugs & Compounds
for IGH@

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IGH@
3 Novoseek chemical compound relationships for IGH@ gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
polyacrylamide 20.43 2 16404354 (1), 10439376 (1)
oligonucleotide 10.85 3 1419624 (1), 10942239 (1), 9443038 (1)
agarose 2.84 1 11489470 (1)
About this table


Transcripts
for IGH@

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section
Inhib.
RNA:		Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Browse siRNA at Sigma-Aldrich  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  


                Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Additional cDNA sequence: 

AF245311.2 AF245312.1 AJ001413.1 AJ230652.1 AJ230653.1 AJ230655.1 AJ230658.1 AJ240562.1 
AJ240564.1 AJ240565.1 AJ240566.1 AJ240567.1 AJ240569.1 AJ276982.1 AJ276985.1 AJ862556.1 
AJ862557.1 AJ862567.1 AJ862572.2 AJ862574.1 AM233752.1 AM233754.1 AM233755.2 AM233756.1 
AM233757.1 AM233758.1 AM233759.1 AM233761.1 AM233762.1 AM233763.1 AM233764.1 AM233766.1 
AM233769.1 AM233770.1 AM233771.1 AM233772.1 AM233774.1 AM233775.1 AM233781.1 AM233782.1 
AY039025.1 AY393093.1 L04768.1 L04769.1 L04771.1 L04772.1 L04773.1 X94051.1 
Z14959.1 Z98699.1 Z98700.1 Z98701.1 Z98702.1 Z98708.1 Z98709.1 Z98710.1 
Z98711.1 Z98712.1 Z98725.1 Z98732.1 

24/489 DOTS entries (see all 489 ):

DT.102844941  DT.100046904  DT.100638236  DT.121646569  DT.91958325  DT.102843901  DT.100046616  DT.121648673 
DT.121651429  DT.121650609  DT.121651889  DT.100034877  DT.121505835  DT.121507991  DT.121651440  DT.121506621 
DT.121509462  DT.121651229  DT.95248569  DT.121507284  DT.121509619  DT.121649966  DT.121652051  DT.121652225 

highest scoring ESTs for IGH@:

AJ001564 

Unigene Cluster for IGH@:

Immunoglobulin heavy locus
Hs.700112  [show with all ESTs]
Unigene Representative Sequence: BF976178


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000390601  

Expression
for IGH@

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IGH@ expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for IGH@

1 / 2 / 3

20 probe-sets matching IGH@ gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

33501_r_at2 U95-A 4 1.00 0.26 0.97 0.94 -- -- -- -- --
33500_i_at2 U95-A 4 1.00 0.25 0.99 0.91 -- -- -- -- --
33499_s_at2 U95-A 4 1.00 0.25 0.99 0.95 -- -- -- -- --
43372_f_at2 U95-B 4 1.00 0.25 0.98 1.11 -- -- -- -- --
57235_s_at2 U95-C 4 1.00 0.25 0.99 1.03 -- -- -- -- --
63612_f_at2, 3 U95-C 8 1.00 0.14 0.98 1.01 AI564488 0.20 0.04 0.14 2
37864_s_at2, 3 U95-A 8 1.00 0.14 0.97 0.91 AJ001564 0.20 0.11 0.16 1
75114_f_at2 U95-D 9 0.88 0.15 0.97 1.15 -- -- -- -- --

228518_at2 U133-B 3 1.00 0.33 -- -- -- -- -- -- --

217022_s_at2 U133-A 4 1.00 0.25 -- -- -- -- -- -- --

211430_s_at2 U133-A 8 1.00 0.13 -- -- -- -- -- -- --

216491_x_at2 U133-A 36 0.91 0.12 -- -- -- -- -- -- --

217236_x_at2 U133-A 27 0.36 0.09 -- -- -- -- -- -- --

1555710_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1555711_x_at2 U133Plus2 6 1.00 0.88 -- -- -- -- -- -- --

228518_at2 U133Plus2 3 1.00 0.33 -- -- -- -- -- -- --

217022_s_at2 U133Plus2 4 1.00 0.25 -- -- -- -- -- -- --

211430_s_at2 U133Plus2 8 1.00 0.13 -- -- -- -- -- -- --

216491_x_at2 U133Plus2 36 0.91 0.12 -- -- -- -- -- -- --

217236_x_at2 U133Plus2 27 0.36 0.09 -- -- -- -- -- -- --
GeneDecks  IGH@ for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.700112

Expression variation in blood from EXPOLDB for IGH@

Orthologs
for IGH@

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for IGH@ gene from 1 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
mouse
(Mus musculus)		 Igh-C5 12 (58.00 cM) immunoglobulin heavy chain constant region   -- -
About this table        Species with no ortholog for IGH@

ENSEMBL Gene Tree for IGH@

Paralogs
for IGH@

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for IGH@

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --

Disorders & Mutations
for IGH@

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

10/39 Novoseek disease relationships for IGH@ gene (see all 39 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma follicular 86.38 16 8619747 (3), 9276187 (2), 18055344 (2), 11245476 (1) (see all 11)
minimal residual disease 81.46 15 19324994 (3), 10485272 (1), 1909409 (1), 8315958 (1) (see all 9)
b-all 79.92 21 1909409 (4), 8315958 (4), 8161789 (3), 8630417 (2) (see all 8)
lymphoblastic leukemia acute 78.89 15 19324994 (3), 1850055 (1), 8187567 (1), 10485272 (1) (see all 13)
lymphoma b-cell 77.40 28 18000389 (4), 16101124 (4), 15191563 (3), 18070448 (2) (see all 13)
lymphoma 74.03 39 9276187 (2), 7856305 (2), 8619747 (2), 11245476 (1) (see all 29)
lymphoma non-hodgkins 73.14 14 12359763 (2), 18005388 (1), 8927349 (1), 9824206 (1) (see all 13)
t-all 70.62 19 10361104 (4), 8161789 (1), 16404354 (1), 10889907 (1) (see all 5)
lymphoblastic leukemia acute childhood 65.65 2 16404354 (1), 9836069 (1)
leukemia 63.91 13 16197448 (2), 10485272 (1), 16681637 (1), 9326200 (1) (see all 12)
About this table

Genetic Association Database: IGH@

Medical News
for IGH@

(Possibly Related Articles in Doctor's Guide)
About This Section

Publications
for IGH@

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/201 PubMed articles for IGH@ gene (see all 201 ):

Search for IGH@

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGH@

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 3492 HGNC: 5477 Ensembl:ENSG00000211941 euGenes: HUgn3492 ECgene: IGH@
H-InvDB: IGH@

Other Databases showing IGH@

(According to HUGE)
About This Section

   --

Specialized Databases showing IGH@

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for IGH@ Genetics and Cytogenetics in Oncology and Haematology
IMGT entry for IGH@ The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Licensable Technologies
for IGH@

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for IGH@

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for IGH@:
 TaqMan ® Gene Expression Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for IGH@-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


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 Search Novus for antibodies for IGH@

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