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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGH@ Cluster

gene cluster GIFtS: 37
GCID: GC14M106032

immunoglobulin heavy locus

(Previous symbol: IGHDY1)

Explore 53 diseases affiliated with
IGH@ via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Immunoglobulin Heavy Locus¹ ²
IGH¹ ²
IGHDY1¹ ²
IGH.1@²
Immunglobulin Heavy Chain Variable Region²

External Ids:	HGNC: 5477¹	Entrez Gene: 3492²	UniProtKB: A2MZT1⁴	UniProtKB: A2N192⁴	UniProtKB: A2NB43⁴
	UniProtKB: A2NB44⁴	UniProtKB: Q6GMX6⁴	UniProtKB: Q6P089⁴

Export aliases for IGH@ gene to outside databases

Previous GC identifers: GC14U990029 GC00U921694 GC14M105276 GC14M105646 GC14M106573 GC14M086299

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGH@:

Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement

system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This

region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity),

J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a

single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged

V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in

development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu

or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is

brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or

epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of

antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of

nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell

maturation in the spleen and lymph nodes. Several V, D, J, and C segments are known to be incapable of encoding a

protein and are considered pseudogenes. (provided by RefSeq, Jul 2008)

Gene Wiki entry for IGH@

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for IGH@
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for IGH@

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGH@

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33

IGH@ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGH@ gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M106032: view genomic region (about GC identifiers)

Start:	106,032,614 bp from pter	End:	107,288,051 bp from pter
Size:	1,255,438 bases	Orientation:	minus strand

IGH@ has overlapping exons with:

ENSG00000238275 ENSG00000265612

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/TrEMBL: A2MZT1 (See protein sequence)

Recommended Name: Immunglobulin heavy chain precursor

Size: 8 amino acids; 943 Da

UniProtKB/TrEMBL: A2N192 (See protein sequence)

Recommended Name: Immunglobulin heavy chain precursor

Size: 151 amino acids; 16787 Da

UniProtKB/TrEMBL: A2NB43 (See protein sequence)

Recommended Name: Cold agglutinin FS-1 H-chain

Size: 118 amino acids; 13053 Da

UniProtKB/TrEMBL: A2NB44 (See protein sequence)

Recommended Name: Cold agglutinin FS-2 H-chain

Size: 114 amino acids; 12761 Da

UniProtKB/TrEMBL: Q6GMX6 (See protein sequence)

Recommended Name: IGH@ protein

Size: 465 amino acids; 51083 Da

1 PDB 3D structure from and Proteopedia for IGH@:

4D9L (3D)

UniProtKB/TrEMBL: Q6P089 (See protein sequence)

Recommended Name: IGH@ protein

Size: 480 amino acids; 51998 Da

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGH@ for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003596 Ig_V-set_subgr

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR003597 Ig_C1-set

IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry A2MZT1

Graphical View of Domain Structure for InterPro Entry A2N192

Graphical View of Domain Structure for InterPro Entry A2NB43

Graphical View of Domain Structure for InterPro Entry A2NB44

Graphical View of Domain Structure for InterPro Entry Q6GMX6

Graphical View of Domain Structure for InterPro Entry Q6P089

ProtoNet protein and cluster: A2MZT1

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGH@
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGH@
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		Browse OriGene 29mer shRNA kits Browse OriGene siRNA
		Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGH@

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IGH@

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		Browse OriGene untagged/tagged cDNA clones in CMV expression vector OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for IGH@
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGH@
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGH@

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGH@
		Search LifeMap BioReagents cell lines for IGH@

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGH@

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_NFAT in immune response

Immune response_NFAT in immune response

1.00

Immune response NFAT in immune response

0.91

Signal transduction_IP3 signaling

Signal transduction_IP3 signaling

1.00

Signal transduction IP3 signaling

0.92

Immune response_Classical complement pathway

Immune response_Classical complement pathway

1.00

Immune response Classic complement pathway

0.98

Immune response_IL-4 signaling pathway

Immune response_IL-4 signaling pathway

1.00

Immune response IL-4 signaling pathway

0.98

Immune response CD16 signaling in NK cells

Immune response CD16 signaling in NK cells

1.00

Immune response_CD16 signaling in NK cells

0.99

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for IGH@ (see all 7)

	Immune response Classic complement pathway
	Immune response BCR pathway
	Immune response CD16 signaling in NK cells
	Signal transduction IP3 signaling
	Immune response IL-4 signaling pathway

5/7 GeneGo (Thomson Reuters) Pathways for IGH@ (see all 7)

	Immune response IL-4 signaling pathway
	Immune response Fc epsilon RI pathway
	Immune response CD16 signaling in NK cells
	Immune response Classical complement pathway
	Immune response BCR pathway

IGH@ for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IGH@

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IGH@ for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGH@
4 Novoseek chemical compound relationships for IGH@ gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ethidium bromide	19.2	1	11489470 (1)
polyacrylamide	18.9	2	16404354 (1), 10439376 (1)
oligonucleotide	9.28	3	1419624 (1), 10942239 (1), 9443038 (1)
agarose	1.19	1	11489470 (1)

Search CenterWatch for drugs/clinical trials and news about IGH@

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for IGH@:

Immunoglobulin heavy locus

Hs.699841 [show with all ESTs]

Unigene Representative Sequence: AK128652

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGH@
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGH@
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		Browse OriGene 29mer shRNA kits Browse OriGene siRNA
		Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGH@

Clone Products:		Browse OriGene untagged/tagged cDNA clones in CMV expression vector OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for IGH@
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGH@
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGH@

Primer Products:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat IGH@
		Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGH@
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGH@

Additional cDNA sequence:

AF067420.1 AF283666.1 AF343666.1 AJ294729.1 AJ491906.1 AJ491907.1 AJ491908.1 AJ491911.1

AJ491912.1 AJ491913.1 AJ491914.1 AJ491915.1 AK027379.1 AK057979.1 AK058027.1 AK074651.1

AK092384.1 AK092803.1 AK093721.1 AK095222.1 AK096985.1 AK097017.1 AK097028.1 AK097076.1

AK097303.1 AK097305.1 AK097320.1 AK097329.1 AK097345.1 AK097348.1 AK097362.1 AK097955.1

AK123546.1 AK123783.1 AK123975.1 AK125079.1 AK125238.1 AK125582.1 AK126279.1 AK126352.1

AK126543.1 AK127921.1 AK128476.1 AK128533.1 AK128565.1 AK128652.1 AK128664.1 AK129592.1

AK129620.1 AK130433.1 AK130453.1 AK130465.1 AK130468.1 AK130476.1 AK130501.1 AK130529.1

AK130796.1 AK130825.1 AK131065.1 AK225676.1 AK301228.1 AL389978.1 AM183979.1 AM183997.1

AY781806.1 AY781809.1 AY781810.1 AY781821.1 AY781825.1 AY781830.1 AY781833.1 AY781834.1

AY781835.1 AY781836.1 AY781837.1 AY781838.1 AY781839.1 AY781840.1 AY781841.1 AY781842.1

AY781850.1 AY781851.1 AY781853.1 AY781857.1 AY781861.1 AY781862.1 AY781864.1 AY781865.1

AY781866.1 AY781872.1 AY781876.1 AY781877.1 AY781889.1 AY885214.2 AY885215.2 BC005951.1

BC016369.1 BC032249.1 BC065733.1 BC066594.1 BC073765.1 BC073771.1 BC087841.1 BC092449.1

BC098451.1 BC113815.1 BX538066.1 BX538077.1 BX640624.1 BX640625.1 BX640626.1 BX640710.1

BX640822.1 BX640847.1 BX640854.1 BX648616.1 DQ005253.1 DQ005256.1 DQ005257.1 DQ005261.1

DQ005269.1 DQ005283.1 DQ005286.1 DQ005295.1 DQ005296.1 DQ005300.1 DQ005301.1 DQ005302.1

DQ869002.1 HM996375.1 M31607.1 S55273.1 S55276.1 S55735.1 S55736.1 U07986.1

X17117.1 X95659.1 X95746.1 Z14960.1 Z14961.1 Z14962.1 Z14963.1 Z46758.1

Z46761.1 Z46762.1 Z46763.1 Z46765.1 Z46766.1 Z46768.1 Z46770.1 Z92888.1

Z92889.1 Z92891.1 Z92893.1 Z97034.1 Z97035.1 Z97036.1 Z97037.1 Z98685.1

Z98691.1 Z98698.1

24/351 DOTS entries (see all 351):

DT.121509328 DT.121509449 DT.100688405 DT.100688414 DT.101987355 DT.121506363 DT.121507821 DT.92471837

DT.121506194 DT.121506420 DT.100046709 DT.100869093 DT.121505973 DT.121507514 DT.100688383 DT.100688385

DT.100688402 DT.121509530 DT.75195766 DT.100046716 DT.100688375 DT.121505835 DT.121509015 DT.121509829

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGH@ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See IGH@ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGH@

SOURCE GeneReport for Unigene cluster: Hs.699841

SABiosciences Custom PCR Arrays for IGH@

Primer Products:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat IGH@
		Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGH@
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGH@

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGH@

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IGH@ gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Igh-C⁵	immunoglobulin heavy chain constant region	--		12 -

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56181824^1,2	C,	--	86523601(+)	`CCATG-/AAGGAA`	1	--	nc-transcript-variant		1	NA	2
rs11847758^1,2	C,F,H,	--	86971194(+)	`ttgtgC/Ttgtgt`	1	--	us2k¹		10	NS EA WA CSA NA	769
rs59652123^1,2	C,	--	86971767(+)	`GGAGGG/AGAAAA`	1	--	us2k¹		2	WA	120
rs111855510^1,2		--	86971808(+)	`CCAAAA/GTTCTC`	1	--	us2k¹		1	CSA	1
rs74093572^1,2	C,	--	86972079(+)	`AAACCA/CAGCAC`	1	--	us2k¹		2	WA CSA	3
rs11848924^1,2	C,F,H,	--	86972221(+)	`accacG/Agggct`	1	--	us2k¹		2	NA WA	6
rs11848880^1,2	C,F,H,	--	86972295(+)	`GCTCTA/GCCATT`	1	--	us2k¹		6	EA NS NA WA	394
rs74093574^1,2	C,	--	86972515(+)	`GGCTCT/CTTCAC`	1	--	us2k¹		2	WA CSA	3
rs113522683^1,2	C,	--	86972856(+)	`CTGATG/TCTGTG`	1	--	int¹		1	WA	2
rs73377177^1,2	C,	--	86973042(+)	`TTCACT/CTTGTT`	1	--	int¹		2	WA	120

HapMap Linkage Disequilibrium report for IGH@ (106032614 - 106282614 bp, first 250kb of IGH@)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IGH@: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGH@

DNA2.0 Custom Variant and Variant Library Synthesis for IGH@

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGH@ for disorders About GeneDecksing

20/53 diseases for IGH@ (see all 53): About MalaCards

monoclonal gammopathy of undetermined significance splenic marginal zone lymphoma b-cell non-hodgkin lymphoma diffuse large b-cell lymphoma

waldenstrom macroglobulinemia non-hodgkin lymphoma central nervous system lymphoma b-cell lymphomas

pleural empyema lymphoplasmacytoid lymphoma malt lymphoma lymphoplasmacytic lymphoma

lymphosarcoma macroglobulinemia lymphoblastic leukemia primary effusion lymphoma

hodgkin's lymphoma lymphocytic leukemia burkitt's lymphoma essential thrombocythemia

1 disease from the University of Copenhagen DISEASES database for IGH@:

Pleural empyema

10/39 Novoseek disease relationships for IGH@ gene (see all 39) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma follicular	86.7	16	8619747 (3), 9276187 (2), 18055344 (2), 11245476 (1) (see all 11)
minimal residual disease	81.4	15	19324994 (3), 10485272 (1), 1909409 (1), 8315958 (1) (see all 9)
lymphoma b-cell	79.6	28	18000389 (4), 16101124 (4), 15191563 (3), 18070448 (2) (see all 13)
b-all	78.8	21	1909409 (4), 8315958 (4), 8161789 (3), 8630417 (2) (see all 8)
lymphoblastic leukemia acute	77.9	15	19324994 (3), 1850055 (1), 8187567 (1), 10485272 (1) (see all 13)
lymphoma	74.7	40	9276187 (2), 7856305 (2), 8619747 (2), 11245476 (1) (see all 29)
lymphoma non-hodgkins	73.9	14	12359763 (2), 18005388 (1), 8927349 (1), 9824206 (1) (see all 13)
t-all	69.3	19	10361104 (4), 8161789 (1), 16404354 (1), 10889907 (1) (see all 5)
lymphoblastic leukemia acute childhood	64.1	2	16404354 (1), 9836069 (1)
leukemia	63.9	13	16197448 (2), 10485272 (1), 16681637 (1), 9326200 (1) (see all 12)

Genetic Association Database (GAD): IGH@
Human Genome Epidemiology (HuGE) Navigator: IGH@ (5 documents)

Export disorders for IGH@ gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGH@ gene, integrated from 9 sources (see all 233):
(articles sorted by number of sources associating them with IGH@)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas. (PubMed id 15191563)^{1, 9} Hallermann C....Neumann C. (2004)
Characterization of genetic lesions in apoptosis-regu lating and proliferation control genes in diffuse large B-cell non-Hodgkin's ly mphoma. (PubMed id 20160358)^{1, 9} Pervez S....Siddiqui T. (2009)
Immunoglobulin heavy chain (IGH@) translocations negat ively impact treatment-free survival for chronic lymphocytic leukemia patients w ho have an isolated deletion 13q abnormality. (PubMed id 22939229)¹ Gerrie A.S....Gillan T.L. (2012)
Polymorphisms of the IgH enhancer HS1.2 and risk of sy stemic lupus erythematosus. (PubMed id 22294636)¹ Frezza D....Ferraccioli G. (2012)
2,3,7,8-tetrachlorodibenzo-p-dioxin induces transcript ional activity of the human polymorphic hs1,2 enhancer of the 3'Igh regulatory r egion. (PubMed id 22357631)¹ Fernando T.M....Sulentic C.E. (2012)
Interaction of human, rat, and mouse immunoglobulin A (IgA) with Staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocy te IgA receptor. (PubMed id 21784854)¹ Wines B.D....Hogarth P.M. (2011)
Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and yo ung adults. (PubMed id 21487109)¹ Salaverria I.... . (2011)
Switching on cytotoxicity by a single mutation at the heavy chain variable region of an anti-ganglioside antibody. (PubMed id 21306777)¹ FernA!ndez-Marrero Y....LA^pez-Requena A. (2011)
High expression of the immature laminin receptor prot ein correlates with mutated IGVH status and predicts a favorable prognosis in c hronic lymphocytic leukemia. (PubMed id 21055809)¹ Friedrichs B....Zeis M. (2011)
Expression and distribution of immunoglobulin G and i ts receptors in an immune privileged site: the eye. (PubMed id 21061041)¹ Niu N....Gu J. (2011)

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Name	Description
PharmGKB entry for IGH@	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IGH@	Genetics and Cytogenetics in Oncology and Haematology
IMGT entry for IGH@	The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

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IGH@ Cluster

immunoglobulin heavy locus

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