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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGH Gene

protein-coding   GIFtS: 27
GCID: GC14M106034

Immunoglobulin Heavy Locus


(Previous symbols: IGHDY1, IGH@)
Pneumococci & Pneumococcal Diseases Congress
  Search for IGH
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Heavy Locus1 2
IGH@1 2
IGHDY11 2
IGH.1@2
Immunglobulin Heavy Chain Variable Region2
AKT15

External Ids:    HGNC: 54771   Entrez Gene: 34922   OMIM: 1647305   

Export aliases for IGH gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGH Gene:
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement
system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This
region represents the germline organization of the heavy chain locus. The locus includes V (variable), D
(diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA
level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V
segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu
heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively
spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch
recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each
cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with
several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional
diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by
somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V, D, J, and
C segments are known to be incapable of encoding a protein and are considered pseudogenes. (provided by RefSeq,
Jul 2008)

GeneCards Summary for IGH Gene: 
IGH (immunoglobulin heavy locus) is a protein-coding gene. Among its related super-pathways are Immune response Lectin induced complement pathway and Immune response Role of DAP12 receptors in NK cells.

summary for IGH Gene:
Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival,
insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway,
resulting in the recruitment of Akt to the plasma membrane via the PH (plexstrin homology domain) of Akt.
Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478
(phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including
transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important
signaling roles (e.g. Bad, MDM2). There are three isoforms of Akt; Akt 1, 2 and 3 (also known as PKBalpha,
beta and gamma).

Gene Wiki entry for IGH (IGH@) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGH
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IGH promoter sequence
   Search SABiosciences Chromatin IP Primers for IGH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   HGNC cytogenetic band: 14q32.33

IGH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGH gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106034:  view genomic region     (about GC identifiers)

Start:
106,032,614 bp from pter      End:
107,288,051 bp from pter
Size:
1,255,438 bases      Orientation:
minus strand
IGH has overlapping exons with:
IGHE IGHVIII-13-1 IGHD5-18 IGHV1-45

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGH: Immunoglobulins / IGH locus

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for IGH 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGH

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGH 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGH 

miRNA
Products:
    
miRTarBase miRNAs that target IGH:
hsa-mir-451 (MIRT005740), hsa-mir-125b (MIRT004363), hsa-mir-185 (MIRT004701), hsa-mir-149 (MIRT005355)

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGH
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGH
SwitchGear 3'UTR luciferase reporter plasmidIGH 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
Browse OriGene RNAi
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGH

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IGH

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for IGH
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGH
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGH

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IGH
Search LifeMap BioReagents cell lines for IGH
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGH


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IGH About                                                                                                See pathways by source

SuperPathContained pathways About
1Immune response Lectin induced complement pathway
Immune response Classic complement pathway0.53
Immune response Classical complement pathway0.52
2Immune response Fc epsilon RI pathway
Immune response Fc epsilon RI pathway0.45
Immune response IL-4 signaling pathway0.38
Immune response BCR pathway0.45
Immune response CD16 signaling in NK cells0.32
3Signal transduction IP3 signaling
Signal transduction IP3 signaling0.92
4Immune response NFAT in immune response
Immune response NFAT in immune response0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/7 EMD Millipore Pathways for IGH (see all 7)
    Immune response Classic complement pathway
Immune response BCR pathway
Immune response CD16 signaling in NK cells
Signal transduction IP3 signaling
Immune response IL-4 signaling pathway


5/8 Tocris Bioscience Pathways for IGH (see all 8)
    Akt Pathway
Insulin Pathway
Toll-like Receptor Pathway
Apoptosis Pathway
TGF-beta Pathway

5/7 GeneGo (Thomson Reuters) Pathways for IGH (see all 7)
    Immune response IL-4 signaling pathway
Immune response Fc epsilon RI pathway
Immune response CD16 signaling in NK cells
Immune response Classical complement pathway
Immune response BCR pathway



IGH for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGH

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IGH for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for IGH available from Tocris Bioscience    About this table
CompoundAction CAS #
10-DEBC hydrochlorideSelective Akt/PKB inhibitor[201788-90-1]
API-2Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral[35943-35-2]
FPA 124Akt/PKB inhibitor[902779-59-3]
API-1Selective Akt/PKB inhibitor. Antitumor[36707-00-3]
SC 79Akt activator[305834-79-1]

4 Novoseek inferred chemical compound relationships for IGH gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ethidium bromide 19.2 1 11489470 (1)
polyacrylamide 18.9 2 16404354 (1), 10439376 (1)
oligonucleotide 9.28 3 1419624 (1), 10942239 (1), 9443038 (1)
agarose 1.19 1 11489470 (1)

Search CenterWatch for drugs/clinical trials and news about IGH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for IGH:

Immunoglobulin heavy locus
Hs.699841  [show with all ESTs]
Unigene Representative Sequence: AK128652

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGH
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGH
SwitchGear 3'UTR luciferase reporter plasmidIGH 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
Browse OriGene RNAi
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGH
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for IGH
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGH
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGH
Primer
Products:
    
Browse OriGene qPCR
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IGH
  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGH
  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGH

Additional mRNA sequence: 

AF067420.1 AF165100.1 AF283666.1 AF343666.1 AJ230648.1 AJ230651.1 AJ230654.1 AJ240561.1 
AJ240563.1 AJ240568.1 AJ276983.1 AJ276984.1 AJ276986.1 AJ276987.1 AJ276988.1 AJ294729.1 
AJ305229.1 AJ309826.1 AJ491906.1 AJ491907.1 AJ491908.1 AJ491911.1 AJ491912.1 AJ491913.1 
AJ491914.1 AJ491915.1 AJ536086.1 AJ862568.1 AJ862569.1 AJ862570.1 AJ862571.1 AK027379.1 
AK057979.1 AK058027.1 AK074651.1 AK092384.1 AK092803.1 AK093721.1 AK095222.1 AK096985.1 
AK097017.1 AK097028.1 AK097076.1 AK097303.1 AK097305.1 AK097320.1 AK097329.1 AK097345.1 
AK097348.1 AK097362.1 AK097955.1 AK123546.1 AK123783.1 AK123975.1 AK125079.1 AK125238.1 
AK125582.1 AK126279.1 AK126352.1 AK126543.1 AK127921.1 AK128476.1 AK128533.1 AK128565.1 
AK128652.1 AK128664.1 AK129592.1 AK129620.1 AK130433.1 AK130453.1 AK130465.1 AK130468.1 
AK130476.1 AK130501.1 AK130529.1 AK130796.1 AK130825.1 AK131065.1 AK225676.1 AK301228.1 
AL389978.1 AM183979.1 AM183997.1 AM233773.1 AM233777.1 AM233778.1 AM233780.1 AM233784.1 
AM233785.1 AY392842.1 AY392843.1 AY392844.1 AY392847.1 AY392848.1 AY392851.1 AY392855.1 
AY392857.1 AY392859.1 AY392860.1 AY392869.1 AY392873.1 AY392877.1 AY392879.1 AY392880.1 
AY392881.1 AY392884.1 AY392885.1 AY392886.1 AY392888.1 AY392892.1 AY392894.1 AY392895.1 
AY392898.1 AY392899.1 AY392901.1 AY392902.1 AY392904.1 AY392906.1 AY392907.1 AY392908.1 
AY392911.1 AY392913.1 AY392914.1 AY392918.1 AY392919.1 AY392924.1 AY392928.1 AY392929.1 
AY392932.1 AY392935.1 AY392936.1 AY392938.1 AY392940.1 AY392941.1 AY392943.1 AY392944.1 
AY392945.1 AY392947.1 AY392949.1 AY392950.1 AY392952.1 AY392953.1 AY392955.1 AY392959.1 
AY392960.1 AY392961.1 AY392963.1 AY392965.1 AY392966.1 AY392967.1 AY392972.1 AY392973.1 
AY392975.1 AY392977.1 AY392978.1 AY392980.1 AY392981.1 AY392982.1 AY392983.1 AY393218.1 
AY393224.1 AY393226.1 AY393232.1 AY393236.1 AY393238.1 AY393240.1 AY393241.1 AY393243.1 
AY393251.1 AY393252.1 AY393255.1 AY393264.1 AY393266.1 AY393268.1 AY393269.1 AY393271.1 
AY393275.1 AY393281.1 AY393282.1 AY393283.1 AY393284.1 AY393287.1 AY393297.1 AY393300.1 
AY393301.1 AY393302.1 AY393305.1 AY393306.1 AY393308.1 AY393309.1 AY393312.1 AY393313.1 
AY393317.1 AY393318.1 AY781806.1 AY781809.1 AY781810.1 AY781821.1 AY781825.1 AY781830.1 
AY781833.1 AY781834.1 AY781835.1 AY781836.1 AY781837.1 AY781838.1 AY781839.1 AY781840.1 
AY781841.1 AY781842.1 AY781850.1 AY781851.1 AY781853.1 AY781857.1 AY781861.1 AY781862.1 
AY781864.1 AY781865.1 AY781866.1 AY781872.1 AY781876.1 AY781877.1 AY781889.1 AY885214.2 
AY885215.2 BC005951.1 BC016369.1 BC032249.1 BC065733.1 BC066594.1 BC073765.1 BC073771.1 
BC087841.1 BC092449.1 BC098451.1 BC113815.1 BX538066.1 BX538077.1 BX640624.1 BX640625.1 
BX640626.1 BX640710.1 BX640822.1 BX640847.1 BX640854.1 BX648616.1 DQ005253.1 DQ005256.1 
DQ005257.1 DQ005261.1 DQ005269.1 DQ005283.1 DQ005286.1 DQ005295.1 DQ005296.1 DQ005300.1 
DQ005301.1 DQ005302.1 DQ869002.1 HF541905.1 HF541908.1 HM994977.1 HM995041.1 HM995167.1 
HM995169.1 HM995170.1 HM995171.1 HM995172.1 HM995182.1 HM995183.1 HM995185.1 HM995187.1 
HM995189.1 HM995203.1 HM995204.1 HM995205.1 HM995206.1 HM995207.1 HM995211.1 HM995216.1 
HM995235.1 HM995244.1 HM995246.1 HM995249.1 HM995268.1 HM995275.1 HM995288.1 HM995308.1 
HM995309.1 HM995310.1 HM995327.1 HM995330.1 HM995345.1 HM995403.1 HM995485.1 HM995487.1 
HM995488.1 HM995498.1 HM995499.1 HM995500.1 HM995502.1 HM995548.1 HM995625.1 HM995847.1 
HM995868.1 HM995925.1 HM995934.1 HM996051.1 HM996112.1 HM996169.1 HM996294.1 HM996305.1 
HM996375.1 HM996381.1 HM996439.1 M31607.1 S55276.1 S55735.1 S55736.1 U07986.1 
X17117.1 X95659.1 X95746.1 Z14960.1 Z14961.1 Z14962.1 Z14963.1 Z46758.1 
Z46761.1 Z46762.1 Z46763.1 Z46765.1 Z46766.1 Z46768.1 Z46770.1 Z92888.1 
Z92889.1 Z92891.1 Z92893.1 Z97034.1 Z97035.1 Z97036.1 Z97037.1 Z98685.1 
Z98691.1 Z98698.1 Z98735.1 Z98736.1 Z98738.1 

24/554 DOTS entries (see all 554):

DT.121509328  DT.121509449  DT.100688405  DT.102844941  DT.100688414  DT.75195766  DT.101987355  DT.121506363 
DT.121507821  DT.92471837  DT.121506194  DT.121506420  DT.100046709  DT.100869093  DT.121505973  DT.121507514 
DT.95368818  DT.100688383  DT.100688385  DT.100688402  DT.121506066  DT.121509530  DT.100688375  DT.100046716 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGH expression in normal human tissues (normalized intensities)      IGH embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGH Expression
About this image


IGH expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/15 selected tissues (see all 15) fully expand
 
 Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
         TONGUE   
 
 Colon (Gastrointestinal Tract)
         Appendix   
 
 Lung (Respiratory System)
         Trachea   
 
 Pancreas (Endocrine System)
         Pancreatic Islet   
 
 Thymus (Hematopoietic System)
         Thymus   

Genevestigator expression for IGH

SOURCE GeneReport for Unigene cluster: Hs.699841
    SABiosciences Custom PCR Arrays for IGH
Primer
Products:
Browse OriGene qPCR
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IGH
Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGH
Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGH
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGH

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IGH gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Igh-C5 immunoglobulin heavy chain constant region   --   12 -

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGH
DNA2.0 Custom Variant and Variant Library Synthesis for IGH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGH for disorders           About MalaCards
OMIM gene information: 164730   
OMIM disorders: 114480  114500  604370  181500  

IGH for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/39 Novoseek inferred disease relationships for IGH gene (see all 39)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma follicular 86.7 16 8619747 (3), 9276187 (2), 18055344 (2), 11245476 (1) (see all 11)
minimal residual disease 81.4 15 19324994 (3), 10485272 (1), 1909409 (1), 8315958 (1) (see all 9)
lymphoma b-cell 79.6 28 18000389 (4), 16101124 (4), 15191563 (3), 18070448 (2) (see all 13)
b-all 78.8 21 1909409 (4), 8315958 (4), 8161789 (3), 8630417 (2) (see all 8)
lymphoblastic leukemia acute 77.9 15 19324994 (3), 1850055 (1), 8187567 (1), 10485272 (1) (see all 13)
lymphoma 74.7 40 9276187 (2), 7856305 (2), 8619747 (2), 11245476 (1) (see all 29)
lymphoma non-hodgkins 73.9 14 12359763 (2), 18005388 (1), 8927349 (1), 9824206 (1) (see all 13)
t-all 69.3 19 10361104 (4), 8161789 (1), 16404354 (1), 10889907 (1) (see all 5)
lymphoblastic leukemia acute childhood 64.1 2 16404354 (1), 9836069 (1)
leukemia 63.9 13 16197448 (2), 10485272 (1), 16681637 (1), 9326200 (1) (see all 12)


Export disorders for IGH gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IGH gene, integrated from 9 sources (see all 239):
(articles sorted by number of sources associating them with IGH)
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  1. Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas. (PubMed id 15191563)1, 9 Hallermann C....Neumann C. (2004)
  2. Characterization of genetic lesions in apoptosis-regu lating and proliferation control genes in diffuse large B-cell non-Hodgkin's ly mphoma. (PubMed id 20160358)1, 9 Pervez S....Siddiqui T. (2009)
  3. T(14;18)(q32;q21) involving MALT1 and IGH genes occurs in extranodal diffuse large B-cell lymphomas of the breast and testis. (PubMed id 23018871)1 Kuper-Hommel M.J....van Krieken J.H. (2013)
  4. High-affinity IgG antibodies develop naturally in Ig-k nockout rats carrying germline human IgH/Igk/Igl loci bearing the rat CH region. (PubMed id 23303672)1 Osborn M.J....Bruggemann M. (2013)
  5. t(11;14)(q23;q32) involving IGH and DDX6 in nodal marg inal zone lymphoma. (PubMed id 22965301)1 Stary S....Streubel B. (2013)
  6. Contribution of V(H) replacement products to the gener ation of anti-HIV antibodies. (PubMed id 23220404)1 Liao H....Zhang Z. (2013)
  7. Immunoglobulin heavy chain (IGH@) translocations negat ively impact treatment-free survival for chronic lymphocytic leukemia patients w ho have an isolated deletion 13q abnormality. (PubMed id 22939229)1 Gerrie A.S....Gillan T.L. (2012)
  8. Immunoglobulin heavy-chain fluorescence in situ hybrid ization-chromogenic in situ hybridization DNA probe split signal in the clonalit y assessment of lymphoproliferative processes on cytological samples. (PubMed id 22517675)1 Zeppa P....Vigliar E. (2012)
  9. Polymorphisms of the IgH enhancer HS1.2 and risk of sy stemic lupus erythematosus. (PubMed id 22294636)1 Frezza D....Ferraccioli G. (2012)
  10. Association of age with fluorescence in situ hybridiza tion abnormalities in multiple myeloma reveals higher rate of IGH translocations among older patients. (PubMed id 22574971)1 Butler C....Costa L.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3492 HGNC: 5477 euGenes: HUgn3492 ECgene: IGH H-InvDB: IGH

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IGH Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IGH gene:
Search GeneIP for patents involving IGH

GeneCards and IP:
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