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Aliases for IGH Gene

Aliases for IGH Gene

  • Immunoglobulin Heavy Locus 2 3
  • Immunoglobulin Heavy Polypeptide, Joining Region 3
  • Immunglobulin Heavy Chain Variable Region 3
  • Immunoglobulin Heavy Diversity Cluster 3
  • Immunoglobulin Heavy Variable Cluster 3
  • D (Diversity) Region Of Heavy Chains 3
  • Immunoglobulin Heavy Diversity Group 3
  • Immunoglobulin Heavy Diversity Locus 3
  • Immunoglobulin Heavy Joining Cluster 3
  • Immunoglobulin Heavy Variable Group 3
  • J (Joining) Region Of Heavy Chains 3
  • Immunoglobulin Heavy Joining Group 3
  • IGH.1@ 3
  • IGHDY1 3
  • IGHD@ 3
  • IGHJ@ 3
  • IGHV@ 3
  • IGD1 3
  • IGHJ 3
  • IGHV 3
  • IGH@ 3

External Ids for IGH Gene

Previous HGNC Symbols for IGH Gene

  • IGHDY1
  • IGH@

Previous GeneCards Identifiers for IGH Gene

  • GC14M106034
  • GC14M105584
  • GC14M105611
  • GC14M105629
  • GC14M105638
  • GC14M105660
  • GC14M105674

Summaries for IGH Gene

Entrez Gene Summary for IGH Gene

  • Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Due to polymorphism, the numbers of functional V, J, and D genes differ among individuals and some V, D, J, and C segments may be pseudogenes. [provided by RefSeq, Oct 2013]

GeneCards Summary for IGH Gene

IGH (Immunoglobulin Heavy Locus) is a Protein Coding gene. Diseases associated with IGH include Follicular Lymphoma 1 and Mantle Cell Lymphoma. Among its related pathways are Development Angiotensin activation of ERK and Development IGF-1 receptor signaling.

Gene Wiki entry for IGH Gene

Additional gene information for IGH Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGH Gene

Genomics for IGH Gene

Regulatory Elements for IGH Gene

Enhancers for IGH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H106879 0.8 ENCODE 0.7 +0.5 456 0 ELF3 CTCF PKNOX1 RAD21 ZIC2 GLIS2 SMC3 ZNF143 PRDM10 CREM ENSG00000211974 IGHVIII-82 IGHV7-81 IGH
GH14H106875 0.5 ENCODE 0.7 +4.1 4137 0 CTCF ZNF654 TRIM22 RAD21 ENSG00000211974 IGHV7-81 IGHVIII-82 IGH
GH14H106877 0.4 ENCODE 0.7 +2.2 2157 0 SP7 IGH IGHVIII-82 IGHV7-81
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGH on UCSC Golden Path with GeneCards custom track

Genomic Location for IGH Gene

Chromosome:
14
Start:
105,566,277 bp from pter
End:
106,879,844 bp from pter
Size:
1,313,568 bases
Orientation:
Minus strand

Genomic View for IGH Gene

Genes around IGH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGH Gene

Proteins for IGH Gene

  • Protein details for IGH Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A2MZT1
    Recommended name:
    Immunglobulin heavy chain
    Protein Accession:
    A2MZT1

    Protein attributes for IGH Gene

    Size:
    8 amino acids
    Molecular mass:
    943 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGH Gene

Post-translational modifications for IGH Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGH Gene

Domains & Families for IGH Gene

Gene Families for IGH Gene

Protein Domains for IGH Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGH: view

No data available for UniProtKB/Swiss-Prot for IGH Gene

Function for IGH Gene

Phenotypes From GWAS Catalog for IGH Gene

Human Phenotype Ontology for IGH Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for IGH

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGH Gene

Localization for IGH Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for IGH Gene

Drugs & Compounds for IGH Gene

(4) Additional Compounds for IGH Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGH: view

Transcripts for IGH Gene

mRNA/cDNA for IGH Gene

(349) Additional mRNA sequences :

Unigene Clusters for IGH Gene

Immunoglobulin heavy locus:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGH Gene

No ASD Table

Relevant External Links for IGH Gene

GeneLoc Exon Structure for
IGH
ECgene alternative splicing isoforms for
IGH

Expression for IGH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGH Gene

NURSA nuclear receptor signaling pathways regulating expression of IGH Gene:

IGH

SOURCE GeneReport for Unigene cluster for IGH Gene:

Hs.699841
genes like me logo Genes that share expression patterns with IGH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGH Gene

Orthologs for IGH Gene

No data available for Orthologs and Evolution for IGH Gene

Paralogs for IGH Gene

No data available for Paralogs for IGH Gene

Variants for IGH Gene

Relevant External Links for IGH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGH Gene

Disorders for IGH Gene

MalaCards: The human disease database

(12) MalaCards diseases for IGH Gene - From: GeneTests, Orphanet, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
follicular lymphoma 1
  • follicular lymphoma
mantle cell lymphoma
  • lymphoma, mantle cell
lymphoma, malt, somatic
  • malt lymphoma
leukemia, acute lymphoblastic 3
  • acute lymphoblastic leukemia, susceptibility to 3
igh-related multiple myeloma
- elite association - COSMIC cancer census association via MalaCards
Search IGH in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGH
genes like me logo Genes that share disorders with IGH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGH Gene

Publications for IGH Gene

  1. Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas. (PMID: 15191563) Hallermann C … Neumann C (The Journal of investigative dermatology 2004) 3 22 60
  2. A new risk variant for multiple sclerosis at the immunoglobulin heavy chain locus associates with intrathecal IgG, IgM index and oligoclonal bands. (PMID: 25392328) Delgado-García M … Lucas M (Multiple sclerosis (Houndmills, Basingstoke, England) 2015) 3 60
  3. Cyclin D1-positive diffuse large B-cell lymphoma with IGH-CCND1 translocation and BCL6 rearrangement: a report of two cases. (PMID: 25596256) Al-Kawaaz M … Tam W (American journal of clinical pathology 2015) 3 60
  4. Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma. (PMID: 25929340) Cowan G … Sahota SS (Oncotarget 2015) 3 60
  5. Prognostic value of circulating Bcl-2/IgH levels in patients with follicular lymphoma receiving first-line immunochemotherapy. (PMID: 26239087) Zohren F … Kobbe G (Blood 2015) 3 60

Products for IGH Gene

Sources for IGH Gene

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