Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGH Gene

Aliases for IGH Gene

  • Immunoglobulin Heavy Locus 2 3
  • Immunoglobulin Heavy Polypeptide, Joining Region 3
  • Immunglobulin Heavy Chain Variable Region 3
  • Immunoglobulin Heavy Diversity Cluster 3
  • Immunoglobulin Heavy Variable Cluster 3
  • D (Diversity) Region Of Heavy Chains 3
  • Immunoglobulin Heavy Diversity Group 3
  • Immunoglobulin Heavy Diversity Locus 3
  • Immunoglobulin Heavy Joining Cluster 3
  • Immunoglobulin Heavy Variable Group 3
  • J (Joining) Region Of Heavy Chains 3
  • Immunoglobulin Heavy Joining Group 3
  • IGH.1@ 3
  • IGHDY1 3
  • IGHD@ 3
  • IGHJ@ 3
  • IGHV@ 3
  • IGD1 3
  • IGHJ 3
  • IGHV 3
  • IGH@ 3

External Ids for IGH Gene

Previous HGNC Symbols for IGH Gene

  • IGHDY1
  • IGH@

Previous GeneCards Identifiers for IGH Gene

  • GC14M106034
  • GC14M105584

Summaries for IGH Gene

Entrez Gene Summary for IGH Gene

  • Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Due to polymorphism, the numbers of functional V, J, and D genes differ among individuals and some V, D, J, and C segments may be pseudogenes. [provided by RefSeq, Oct 2013]

GeneCards Summary for IGH Gene

IGH (Immunoglobulin Heavy Locus) is a Protein Coding gene. Diseases associated with IGH include follicular lymphoma and mantle cell lymphoma. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Immune response NFAT in immune response.

Gene Wiki entry for IGH Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGH Gene

Genomics for IGH Gene

Genomic Location for IGH Gene

Chromosome:
14
Start:
105,566,277 bp from pter
End:
106,879,844 bp from pter
Size:
1,313,568 bases
Orientation:
Minus strand

Genomic View for IGH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for IGH Gene

No data available for Regulatory Elements for IGH Gene

Proteins for IGH Gene

Post-translational modifications for IGH Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGH Gene

Domains & Families for IGH Gene

Gene Families for IGH Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGH: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for IGH Gene

Function for IGH Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGH Gene

Localization for IGH Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IGH Gene

Drugs & Compounds for IGH Gene

(4) Additional Compounds for IGH Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Agarose
ethidium bromide
Oligonucleotide
Polyacrylamide
genes like me logo Genes that share compounds with IGH: view

Transcripts for IGH Gene

mRNA/cDNA for IGH Gene

(349) Additional mRNA sequences :

Unigene Clusters for IGH Gene

Immunoglobulin heavy locus:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGH Gene

No ASD Table

Relevant External Links for IGH Gene

GeneLoc Exon Structure for
IGH
ECgene alternative splicing isoforms for
IGH

Expression for IGH Gene

mRNA expression in normal human tissues for IGH Gene

SOURCE GeneReport for Unigene cluster for IGH Gene Hs.699841

genes like me logo Genes that share expression patterns with IGH: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IGH Gene

Orthologs for IGH Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for IGH Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Igh-C 16
Species with no ortholog for IGH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for IGH Gene

Paralogs for IGH Gene

No data available for Paralogs for IGH Gene

Variants for IGH Gene

Relevant External Links for IGH Gene

HapMap Linkage Disequilibrium report
IGH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGH Gene

Disorders for IGH Gene

MalaCards: The human disease database

(10) MalaCards diseases for IGH Gene - From: Orphanet, NovoSeek, and GeneCards

- elite association
Search IGH in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGH
genes like me logo Genes that share disorders with IGH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGH Gene

Publications for IGH Gene

  1. Histiocytic sarcoma arising in indolent small B-cell lymphoma: report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution. (PMID: 20331331) Wang E. … Datto M. (Leuk. Lymphoma 2010) 23 67
  2. Genetic and immunophenotypic profile of IGH@ rearrangement detected by fluorescence in situ hybridization in 149 cases of B-cell chronic lymphocytic leukemia. (PMID: 19963136) Lu G. … Yue C. (Cancer Genet. Cytogenet. 2010) 23 67
  3. Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia. (PMID: 19324994) Brisco M.J. … Morley A.A. (J Mol Diagn 2009) 23 67
  4. [Immunoglobulin genes and T-cell receptors as molecular markers in children with acute lymphoblastic leukaemia]. (PMID: 19764592) LaziA8 J. … JaniA8 D. (Srp Arh Celok Lek 2009) 23 67
  5. Immunoglobulin light chain gene translocations in non-Hodgkin's lymphoma as assessed by fluorescence in situ hybridisation. (PMID: 18005388) Fujimoto Y. … Taniwaki M. (Eur. J. Haematol. 2008) 23 67

Products for IGH Gene

Sources for IGH Gene

Back to Top

Content