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Aliases for IGH Gene

Aliases for IGH Gene

  • Immunoglobulin Heavy Locus 2 3
  • Immunoglobulin Heavy Polypeptide, Joining Region 3
  • Immunglobulin Heavy Chain Variable Region 3
  • Immunoglobulin Heavy Diversity Cluster 3
  • Immunoglobulin Heavy Variable Cluster 3
  • D (Diversity) Region Of Heavy Chains 3
  • Immunoglobulin Heavy Diversity Group 3
  • Immunoglobulin Heavy Diversity Locus 3
  • Immunoglobulin Heavy Joining Cluster 3
  • Immunoglobulin Heavy Variable Group 3
  • J (Joining) Region Of Heavy Chains 3
  • Immunoglobulin Heavy Joining Group 3
  • IGH.1@ 3
  • IGHDY1 3
  • IGHD@ 3
  • IGHJ@ 3
  • IGHV@ 3
  • IGD1 3
  • IGHJ 3
  • IGHV 3
  • IGH@ 3

External Ids for IGH Gene

Previous HGNC Symbols for IGH Gene

  • IGHDY1
  • IGH@

Previous GeneCards Identifiers for IGH Gene

  • GC14M106034

Summaries for IGH Gene

Entrez Gene Summary for IGH Gene

  • Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Due to polymorphism, the numbers of functional V, J, and D genes differ among individuals and some V, D, J, and C segments may be pseudogenes. [provided by RefSeq, Oct 2013]

GeneCards Summary for IGH Gene

IGH (Immunoglobulin Heavy Locus) is a Protein Coding gene. Diseases associated with IGH include precursor b-cell acute lymphoblastic leukemia and follicular lymphoma. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Immune response NFAT in immune response.

Gene Wiki entry for IGH Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGH Gene

Genomics for IGH Gene

Genomic Location for IGH Gene

105,566,277 bp from pter
106,879,844 bp from pter
1,313,568 bases
Minus strand

Genomic View for IGH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGH Gene

No data available for Regulatory Elements for IGH Gene

Proteins for IGH Gene

Post-translational modifications for IGH Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGH Gene

Domains for IGH Gene

Gene Families for IGH Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGH: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGH Gene

Function for IGH Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGH Gene

Localization for IGH Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IGH Gene

Drugs for IGH Gene

(4) Novoseek inferred chemical compound relationships for IGH Gene

Compound -log(P) Hits PubMed IDs
ethidium bromide 19.2 1
polyacrylamide 18.9 2
oligonucleotide 9.28 3
agarose 1.19 1
genes like me logo Genes that share compounds with IGH: view

Transcripts for IGH Gene

mRNA/cDNA for IGH Gene

(349) Additional mRNA sequences :

Unigene Clusters for IGH Gene

Immunoglobulin heavy locus:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGH Gene

No ASD Table

Relevant External Links for IGH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGH Gene

mRNA expression in normal human tissues for IGH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for IGH Gene Hs.699841

genes like me logo Genes that share expressions with IGH: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for IGH Gene

Orthologs for IGH Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for IGH Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Igh-C 16
Species with no ortholog for IGH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for IGH Gene

Paralogs for IGH Gene

No data available for Paralogs for IGH Gene

Variants for IGH Gene

Relevant External Links for IGH Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGH Gene

Disorders for IGH Gene

(39) Novoseek inferred disease relationships for IGH Gene

Disease -log(P) Hits PubMed IDs
lymphoma follicular 86.7 15
minimal residual disease 81.4 11
lymphoma b-cell 79.6 24
b-all 78.8 17
lymphoblastic leukemia acute 77.9 15
genes like me logo Genes that share disorders with IGH: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for IGH Gene

Publications for IGH Gene

  1. Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas. (PMID: 15191563) Hallermann C. … Neumann C. (J. Invest. Dermatol. 2004) 3 23
  2. An inv(16)(p13q22) positive acute myeloid leukaemia relapsing as acute precursor B-cell lymphoblastic leukaemia. (PMID: 15339697) Boeckx N. … van Dongen J.J. (Haematologica 2004) 23
  3. Both IGH translocations and chromosome 13q deletions are early events in monoclonal gammopathy of undetermined significance and do not evolve during transition to multiple myeloma. (PMID: 15385925) Kaufmann H. … Drach J. (Leukemia 2004) 23
  4. An ATL cell line with an IgH pseudo-rearranged band pattern by southern blotting: a pitfall of genetic diagnosis. (PMID: 15790547) Uemura A. … Kamihira S. (Lab Hematol 2005) 23
  5. [Long distance vectorette PCR for detecting translocation of IgH gene in switch regions of patients with multiple myeloma]. (PMID: 15972142) Guo C. … Jiang H. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005) 23

Products for IGH Gene

Sources for IGH Gene

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