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Aliases for IGFN1 Gene

Aliases for IGFN1 Gene

  • Immunoglobulin-Like And Fibronectin Type III Domain Containing 1 2 3
  • EEF1A2-Binding Protein 1 3 4
  • KY-Interacting Protein 1 3 4
  • EEF1A2BP1 3 4
  • Immunoglobulin-Like And Fibronectin Type III Domain-Containing Protein 1 3
  • EEF1A2 Binding Protein 3
  • KYIP1 4

External Ids for IGFN1 Gene

Summaries for IGFN1 Gene

GeneCards Summary for IGFN1 Gene

IGFN1 (Immunoglobulin-Like And Fibronectin Type III Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is MYBPC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFN1 Gene

Genomics for IGFN1 Gene

Genomic Location for IGFN1 Gene

Start:
201,190,824 bp from pter
End:
201,228,952 bp from pter
Size:
38,129 bases
Orientation:
Plus strand

Genomic View for IGFN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGFN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFN1 Gene

Regulatory Elements for IGFN1 Gene

Proteins for IGFN1 Gene

  • Protein details for IGFN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VF2-IGFN1_HUMAN
    Recommended name:
    Immunoglobulin-like and fibronectin type III domain-containing protein 1
    Protein Accession:
    Q86VF2
    Secondary Accessions:
    • F8WAI1
    • Q9NT72

    Protein attributes for IGFN1 Gene

    Size:
    1251 amino acids
    Molecular mass:
    137763 Da
    Quaternary structure:
    • Interacts with FLNC (By similarity). Interacts with KY.

    Alternative splice isoforms for IGFN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFN1 Gene

Proteomics data for IGFN1 Gene at MOPED

Post-translational modifications for IGFN1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser593

Other Protein References for IGFN1 Gene

No data available for DME Specific Peptides for IGFN1 Gene

Domains for IGFN1 Gene

Gene Families for IGFN1 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • FN3 :Fibronectin type III domain containing

Protein Domains for IGFN1 Gene

UniProtKB/Swiss-Prot:

IGFN1_HUMAN
Domain:
  • Contains 4 fibronectin type-III domains.:
    • Q86VF2
  • Contains 5 Ig-like (immunoglobulin-like) domains.:
    • Q86VF2
genes like me logo Genes that share domains with IGFN1: view

Function for IGFN1 Gene

Gene Ontology (GO) - Molecular Function for IGFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IGFN1: view

miRNA for IGFN1 Gene

miRTarBase miRNAs that target IGFN1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGFN1 Gene

Localization for IGFN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFN1 Gene

Nucleus. Cytoplasm, myofibril, sarcomere, Z line.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFN1 Gene COMPARTMENTS Subcellular localization image for IGFN1 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for IGFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0030018 Z disc ISS --
genes like me logo Genes that share ontologies with IGFN1: view

Pathways for IGFN1 Gene

SuperPathways for IGFN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with IGFN1: view

No data available for Pathways by source for IGFN1 Gene

Transcripts for IGFN1 Gene

Unigene Clusters for IGFN1 Gene

Immunoglobulin-like and fibronectin type III domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGFN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1:
SP2: -

Relevant External Links for IGFN1 Gene

GeneLoc Exon Structure for
IGFN1
ECgene alternative splicing isoforms for
IGFN1

Expression for IGFN1 Gene

mRNA expression in normal human tissues for IGFN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFN1 Gene

This gene is overexpressed in Muscle - Skeletal (35.6) and Thyroid (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IGFN1 Gene

SOURCE GeneReport for Unigene cluster for IGFN1 Gene Hs.519024

mRNA Expression by UniProt/SwissProt for IGFN1 Gene

Q86VF2-IGFN1_HUMAN
Tissue specificity: Expressed in skeletal muscle.
genes like me logo Genes that share expressions with IGFN1: view

Orthologs for IGFN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGFN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFN1 36
  • 97.84 (n)
  • 96.43 (a)
cow
(Bos Taurus)
Mammalia IGFN1 37
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 65 (a)
OneToMany
-- 37
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Igfn1 36
  • 69.77 (n)
  • 59.55 (a)
Igfn1 16
Igfn1 37
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFN1 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFN1 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igfn1 36
  • 66.84 (n)
  • 55.68 (a)
chicken
(Gallus gallus)
Aves IGFN1 37
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGFN1 37
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii IGFN1 (2 of 4) 37
  • 37 (a)
OneToMany
IGFN1 (3 of 4) 37
  • 35 (a)
OneToMany
IGFN1 (4 of 4) 37
  • 38 (a)
OneToMany
igfn1.1 37
  • 37 (a)
OneToMany
LOC100331959 36
  • 51.35 (n)
  • 41.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14964 37
  • 9 (a)
ManyToMany
sls 37
  • 2 (a)
ManyToMany
Species with no ortholog for IGFN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFN1 Gene

ENSEMBL:
Gene Tree for IGFN1 (if available)
TreeFam:
Gene Tree for IGFN1 (if available)

Paralogs for IGFN1 Gene

Paralogs for IGFN1 Gene

Selected SIMAP similar genes for IGFN1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IGFN1: view

Variants for IGFN1 Gene

Sequence variations from dbSNP and Humsavar for IGFN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12466 -- 201,228,680(-) CCTGA(A/T)GCGAA utr-variant-3-prime
rs14061 -- 201,228,653(+) ACCCT(C/T)ACCAT utr-variant-3-prime
rs831750 -- 201,190,333(-) CAGGA(A/G)GGAGG upstream-variant-2KB
rs831751 -- 201,189,848(-) AAGTA(C/T)GTGTA upstream-variant-2KB
rs832155 -- 201,195,081(-) GAGTG(A/G)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFN1 Gene

Variant ID Type Subtype PubMed ID
nsv428301 CNV Gain 18775914
esv25305 CNV Gain 19812545
esv2721406 CNV Deletion 23290073
esv1570400 CNV Deletion 17803354
esv1754216 CNV Insertion 17803354
esv2721417 CNV Deletion 23290073
nsv518716 CNV Loss 19592680

Relevant External Links for IGFN1 Gene

HapMap Linkage Disequilibrium report
IGFN1

Disorders for IGFN1 Gene

Relevant External Links for IGFN1

Genetic Association Database (GAD)
IGFN1
Human Genome Epidemiology (HuGE) Navigator
IGFN1
genes like me logo Genes that share disorders with IGFN1: view

No data available for UniProtKB/Swiss-Prot for IGFN1 Gene

Publications for IGFN1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres. (PMID: 15385448) Beatham J. … Blanco G. (Hum. Mol. Genet. 2004) 3 4
  3. Translation elongation factor eEF1A binds to a novel myosin binding protein-C-like protein. (PMID: 18756455) Mansilla F. … Knudsen C.R. (J. Cell. Biochem. 2008) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for IGFN1 Gene

Sources for IGFN1 Gene

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