IGFN1 Gene
protein-coding GIFtS: 46
GCID: GC01P201159
|
|
immunoglobulin-like and fibronectin type III domain containing...
| |
Aliases
for IGFN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Immunoglobulin-Like And Fibronectin Type III Domain Containing 11 2 | | DKFZp434B12311 | | EEF1A2BP11 2 3 | | EEF1A2 Binding Protein2 | | EEF1A2-Binding Protein 12 3 | | Immunoglobulin-Like And Fibronectin Type III Domain-Containing Protein 12 | | KY-Interacting Protein 12 3 | | KYIP13 |
Export aliases for IGFN1 gene to outside databasesPrevious GC identifers: GC01P199448 GC01P172326 |
Summaries
for IGFN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for IGFN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IGFN1 gene promoter:
USF1 RelA Nkx2-5 NF-kappaB E47 N-Myc USF-1 Zic1 Chx10 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IGFN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1IGFN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P201159: view genomic region
(about GC identifiers)
Start:
|
201,159,953 bp from pter |
End:
|
201,198,080 bp from pter |
Size:
|
38,128 bases |
Orientation:
|
plus strand |
|
Proteins
for IGFN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IGFN1_HUMAN, Q86VF2 (See
protein sequence)Recommended Name: Immunoglobulin-like and fibronectin type III domain-containing protein 1 Size: 1251 amino acids; 137763 Da
Subunit: Interacts with FLNC (By similarity). Interacts with KY
Subcellular location: Nucleus (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By similarity)
Secondary accessions: F8WAI1 Q9NT72Alternative splicing: 5 isoforms: Q86VF2-1 Q86VF2-2 Q86VF2-3 Q86VF2-4 Q86VF2-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for IGFN1: NX_Q86VF2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86VF2
IGFN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001158058.1
ENSEMBL proteins: ENSP00000399041 ENSP00000387975 ENSP00000334714 ENSP00000398386 ENSP00000295591
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
IGFN1 for ontologies About GeneDecksing
IGFN1 Antibody Products:
Assay Products for IGFN1: |
Protein
Domains /
Families
for IGFN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IGFN1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q86VF2ProtoNet protein and cluster: Q86VF2 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013098 Immunoglobulin I-set
UniProtKB/Swiss-Prot: IGFN1_HUMAN, Q86VF2Similarity: Contains 4 fibronectin type-III domainsSimilarity: Contains 5 Ig-like (immunoglobulin-like) domains |
Function
for IGFN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFN1 |
|
Pathways & Interactions
for IGFN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGFN1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for IGFN1 (Q86VF23 ENSP000003347144) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
IGFN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for IGFN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IGFN1
Search CenterWatch for drugs/clinical trials and news about IGFN1 
|
Transcripts
for IGFN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IGFN1 gene (2 alternative transcripts): NM_001164586.1 NM_178275.4 Unigene Cluster for IGFN1: Immunoglobulin-like and fibronectin type III domain containing 1 Hs.519024 [show with all ESTs]Unigene Representative Sequence: NM_0011645867 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000437879 ENST00000444705 ENST00000412892 ENST00000473483 ENST00000335211(uc001gwc.3 uc001gwb.3)
ENST00000451870 ENST00000295591
Additional cDNA sequence: AL137493.1 AY245430.2 BC028184.1 BC033185.1 BC131529.1 5 DOTS entries: DT.100742766 DT.410139 DT.95099792 DT.95186603 DT.91744136 24/31 AceView cDNA sequences (see all 31): AI247998 AA180838 AA211777 AL137493 AY245430 BF510813 BX105048 BQ188954 CB529233 NM_178275 AA441900 BG166404 BC033185 BC028184 AA776394 BG418952 AI076730 AA678805 BG423214 AA180179 AW732600 AI039158 BI005570 R98454
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for IGFN1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for IGFN1
|
Expression
for IGFN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IGFN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTGTGCCG
About this image
See IGFN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGFN1
SOURCE GeneReport for Unigene cluster: Hs.519024
UniProtKB/Swiss-Prot: IGFN1_HUMAN, Q86VF2Tissue specificity: Expressed in skeletal muscle
SABiosciences Custom PCR Arrays for IGFN1
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGFN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IGFN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFN1 |
Orthologs
for IGFN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for IGFN1 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for IGFN1 (if available)
TreeFam Gene Tree for IGFN1 (if available) |
Paralogs
for IGFN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IGFN1 gene
- MYOM12 MYBPH2 IGSF222 MYBPC22 MYBPC12 MYBPC32 MYBPHL2 MYOM32
- MYOM22
3 SIMAP similar genes for IGFN1 using alignment to 3 protein entries: IGFN1_HUMAN (see all proteins):MUSK IGSF22 TTN
IGFN1 for paralogs About GeneDecksing
|
Genomic Variants
for IGFN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IGFN1 (201159953 - 201198080 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for IGFN1
10 CNVs: 84786 84787 74858 70944 84788 84785 74856 74859 70943 74857
1 Indel: 24039 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for IGFN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IGFN1 for disorders About GeneDecksing
1  disease for IGFN1: About MalaCardsmuscular dystrophy
Human Genome Epidemiology (HuGE) Navigator: IGFN1 (1 document)
Export disorders for IGFN1 gene to outside databases
|
Publications
for IGFN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IGFN1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGFN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres. (PubMed id 15385448)1, 2 Beatham J....Blanco G. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Translation elongation factor eEF1A binds to a novel myosin binding protein-C-like protein. (PubMed id 18756455)1 Mansilla F....Knudsen C.R. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for IGFN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IGFN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IGFN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IGFN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IGFN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IGFN1 gene:
Search GeneIP for patents involving IGFN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IGFN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IGFN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGFN1 | | | OriGene Protein Over-expression Lysate for IGFN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IGFN1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | Browse OriGene untagged cDNA clones in CMV expression vector | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IGFN1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IGFN1 | | OriGene Custom Protein Services for IGFN1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGFN1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFN1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for IGFN1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | IGFN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFN1 |
|  |  |  | | | | Search ThermoFisher Antibodies for IGFN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFN1 |
|
|
|
|
