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Aliases for IGFN1 Gene

Aliases for IGFN1 Gene

  • Immunoglobulin-Like And Fibronectin Type III Domain Containing 1 2 3 5
  • EEF1A2-Binding Protein 1 3 4
  • KY-Interacting Protein 1 3 4
  • EEF1A2BP1 3 4
  • Immunoglobulin-Like And Fibronectin Type III Domain-Containing Protein 1 3
  • EEF1A2 Binding Protein 3
  • KYIP1 4

External Ids for IGFN1 Gene

Previous GeneCards Identifiers for IGFN1 Gene

  • GC01P199448
  • GC01P172326

Summaries for IGFN1 Gene

GeneCards Summary for IGFN1 Gene

IGFN1 (Immunoglobulin-Like And Fibronectin Type III Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is IGSF22.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFN1 Gene

Genomics for IGFN1 Gene

Regulatory Elements for IGFN1 Gene

Enhancers for IGFN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F201169 1.2 FANTOM5 ENCODE 16.9 -19.5 -19461 4.0 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000229821 IGFN1 RNPEP ENSG00000273478 DDX59 IPO9-AS1 IPO9 TMEM9 ASCL5
GH01F201305 1.6 FANTOM5 Ensembl ENCODE 11.5 +118.8 118808 7.5 HDGF PKNOX1 MLX ARID4B SIN3A ZNF48 BRCA1 YY1 GATA2 ZNF143 PKP1 LAD1 ENSG00000229821 IGFN1 ASCL5 CACNA1S C1orf106 GC01P201285 GC01M201335
GH01F201142 0.4 ENCODE 11.3 -48.1 -48099 0.1 ZNF263 TMEM9 CACNA1S IGFN1 ENSG00000229821 ENSG00000234132 ASCL5
GH01F201153 1.1 ENCODE 11.1 -36.4 -36414 1.7 HDGF PKNOX1 ARNT SIN3A ARID4B DMAP1 YY1 CBX5 ZNF143 FOS TMEM9 DDX59 IGFN1 ASCL5 CACNA1S KIF14 ENSG00000229821
GH01F201136 0.2 ENCODE 11.1 -53.1 -53093 1.6 KLF1 JUND CEBPA CEBPB FOS CACNA1S ASCL5 IGFN1 TMEM9 PKP1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGFN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGFN1 Gene

Chromosome:
1
Start:
201,190,806 bp from pter
End:
201,228,952 bp from pter
Size:
38,147 bases
Orientation:
Plus strand

Genomic View for IGFN1 Gene

Genes around IGFN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFN1 Gene

Proteins for IGFN1 Gene

  • Protein details for IGFN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VF2-IGFN1_HUMAN
    Recommended name:
    Immunoglobulin-like and fibronectin type III domain-containing protein 1
    Protein Accession:
    Q86VF2
    Secondary Accessions:
    • F8WAI1
    • Q9NT72

    Protein attributes for IGFN1 Gene

    Size:
    1251 amino acids
    Molecular mass:
    137763 Da
    Quaternary structure:
    • Interacts with FLNC (By similarity). Interacts with KY.

    Alternative splice isoforms for IGFN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFN1 Gene

Post-translational modifications for IGFN1 Gene

  • Glycosylation at Ser 593
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IGFN1 Gene

Domains & Families for IGFN1 Gene

Suggested Antigen Peptide Sequences for IGFN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VF2

UniProtKB/Swiss-Prot:

IGFN1_HUMAN :
  • Contains 4 fibronectin type-III domains.
Domain:
  • Contains 4 fibronectin type-III domains.
  • Contains 5 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGFN1: view

Function for IGFN1 Gene

Gene Ontology (GO) - Molecular Function for IGFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IGFN1: view
genes like me logo Genes that share phenotypes with IGFN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFN1

miRNA for IGFN1 Gene

miRTarBase miRNAs that target IGFN1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IGFN1

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFN1 Gene

Localization for IGFN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFN1 Gene

Nucleus. Cytoplasm, myofibril, sarcomere, Z line.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFN1 Gene COMPARTMENTS Subcellular localization image for IGFN1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for IGFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0030018 Z disc ISS --
genes like me logo Genes that share ontologies with IGFN1: view

Pathways & Interactions for IGFN1 Gene

SuperPathways for IGFN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with IGFN1: view

No data available for Pathways by source and SIGNOR curated interactions for IGFN1 Gene

Transcripts for IGFN1 Gene

Unigene Clusters for IGFN1 Gene

Immunoglobulin-like and fibronectin type III domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IGFN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1:
SP2: -

Relevant External Links for IGFN1 Gene

GeneLoc Exon Structure for
IGFN1
ECgene alternative splicing isoforms for
IGFN1

Expression for IGFN1 Gene

mRNA expression in normal human tissues for IGFN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFN1 Gene

This gene is overexpressed in Muscle - Skeletal (x35.6) and Thyroid (x6.7).

Protein differential expression in normal tissues from HIPED for IGFN1 Gene

This gene is overexpressed in Urine (57.4) and Plasma (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGFN1 Gene



Protein tissue co-expression partners for IGFN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGFN1 Gene:

IGFN1

SOURCE GeneReport for Unigene cluster for IGFN1 Gene:

Hs.519024

mRNA Expression by UniProt/SwissProt for IGFN1 Gene:

Q86VF2-IGFN1_HUMAN
Tissue specificity: Expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with IGFN1: view

Primer Products

Orthologs for IGFN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGFN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFN1 34
  • 97.84 (n)
mouse
(Mus musculus)
Mammalia Igfn1 34 16 35
  • 69.77 (n)
rat
(Rattus norvegicus)
Mammalia Igfn1 34
  • 66.84 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 65 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia IGFN1 35
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFN1 35
  • 59 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGFN1 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGFN1 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGFN1 35
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100331959 34
  • 51.35 (n)
IGFN1 (4 of 4) 35
  • 38 (a)
OneToMany
IGFN1 (2 of 4) 35
  • 37 (a)
OneToMany
igfn1.1 35
  • 37 (a)
OneToMany
IGFN1 (3 of 4) 35
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14964 35
  • 9 (a)
ManyToMany
sls 35
  • 2 (a)
ManyToMany
Species where no ortholog for IGFN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFN1 Gene

ENSEMBL:
Gene Tree for IGFN1 (if available)
TreeFam:
Gene Tree for IGFN1 (if available)

Paralogs for IGFN1 Gene

Paralogs for IGFN1 Gene

(2) SIMAP similar genes for IGFN1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IGFN1: view

Variants for IGFN1 Gene

Sequence variations from dbSNP and Humsavar for IGFN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1007227 -- 201,194,971(-) AGGAA(C/T)CCCTC intron-variant
rs1007228 -- 201,194,696(-) CCCAG(C/T)CTGTG intron-variant
rs10157719 -- 201,201,443(+) CAACT(A/G)ATGTT intron-variant
rs10157730 -- 201,201,644(+) ACCAG(A/G)GCCTA intron-variant
rs10158976 -- 201,201,696(+) TCCTG(C/G)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFN1 Gene

Variant ID Type Subtype PubMed ID
esv1570400 CNV deletion 17803354
esv1754216 CNV insertion 17803354
esv25305 CNV gain 19812545
esv2721406 CNV deletion 23290073
esv2721417 CNV deletion 23290073
nsv1121446 CNV deletion 24896259
nsv1141747 CNV insertion 24896259
nsv428301 CNV gain 18775914
nsv518716 CNV loss 19592680
nsv548992 CNV loss 21841781

Variation tolerance for IGFN1 Gene

Gene Damage Index Score: 23.83; 99.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFN1 Gene

Disorders for IGFN1 Gene

Relevant External Links for IGFN1

Genetic Association Database (GAD)
IGFN1
Human Genome Epidemiology (HuGE) Navigator
IGFN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFN1

No disorders were found for IGFN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGFN1 Gene

Publications for IGFN1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres. (PMID: 15385448) Beatham J. … Blanco G. (Hum. Mol. Genet. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Translation elongation factor eEF1A binds to a novel myosin binding protein-C-like protein. (PMID: 18756455) Mansilla F. … Knudsen C.R. (J. Cell. Biochem. 2008) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for IGFN1 Gene

Sources for IGFN1 Gene

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