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Aliases for IGFN1 Gene

Aliases for IGFN1 Gene

  • Immunoglobulin-Like And Fibronectin Type III Domain Containing 1 2 3 5
  • EEF1A2-Binding Protein 1 3 4
  • KY-Interacting Protein 1 3 4
  • EEF1A2BP1 3 4
  • EEF1A2 Binding Protein 3
  • KYIP1 4

External Ids for IGFN1 Gene

Previous GeneCards Identifiers for IGFN1 Gene

  • GC01P199448
  • GC01P172326

Summaries for IGFN1 Gene

GeneCards Summary for IGFN1 Gene

IGFN1 (Immunoglobulin-Like And Fibronectin Type III Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is MYBPC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFN1 Gene

Genomics for IGFN1 Gene

Regulatory Elements for IGFN1 Gene

Enhancers for IGFN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IGFN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGFN1 Gene

201,190,806 bp from pter
201,228,952 bp from pter
38,147 bases
Plus strand

Genomic View for IGFN1 Gene

Genes around IGFN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFN1 Gene

Proteins for IGFN1 Gene

  • Protein details for IGFN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin-like and fibronectin type III domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • F8WAI1
    • Q9NT72

    Protein attributes for IGFN1 Gene

    1251 amino acids
    Molecular mass:
    137763 Da
    Quaternary structure:
    • Interacts with FLNC (By similarity). Interacts with KY.

    Alternative splice isoforms for IGFN1 Gene


neXtProt entry for IGFN1 Gene

Proteomics data for IGFN1 Gene at MOPED

Post-translational modifications for IGFN1 Gene

  • Glycosylation at Ser 593
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFN1 Gene

No data available for DME Specific Peptides for IGFN1 Gene

Domains & Families for IGFN1 Gene

Protein Domains for IGFN1 Gene

Suggested Antigen Peptide Sequences for IGFN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 fibronectin type-III domains.
  • Contains 4 fibronectin type-III domains.
  • Contains 5 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGFN1: view

Function for IGFN1 Gene

genes like me logo Genes that share phenotypes with IGFN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFN1

CRISPR Products

miRNA for IGFN1 Gene

miRTarBase miRNAs that target IGFN1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFN1 Gene

Localization for IGFN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFN1 Gene

Nucleus. Cytoplasm, myofibril, sarcomere, Z line.

Subcellular locations from

Jensen Localization Image for IGFN1 Gene COMPARTMENTS Subcellular localization image for IGFN1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for IGFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030018 Z disc ISS --
genes like me logo Genes that share ontologies with IGFN1: view

Pathways & Interactions for IGFN1 Gene

SuperPathways for IGFN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGFN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGFN1 Gene

Drugs & Compounds for IGFN1 Gene

No Compound Related Data Available

Transcripts for IGFN1 Gene

Unigene Clusters for IGFN1 Gene

Immunoglobulin-like and fibronectin type III domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGFN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP2: -

Relevant External Links for IGFN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGFN1 Gene

mRNA expression in normal human tissues for IGFN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFN1 Gene

This gene is overexpressed in Muscle - Skeletal (x35.6) and Thyroid (x6.7).

Protein differential expression in normal tissues from HIPED for IGFN1 Gene

This gene is overexpressed in Urine (57.4) and Plasma (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGFN1 Gene

SOURCE GeneReport for Unigene cluster for IGFN1 Gene Hs.519024

mRNA Expression by UniProt/SwissProt for IGFN1 Gene

Tissue specificity: Expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with IGFN1: view

Protein tissue co-expression partners for IGFN1 Gene

Primer Products

In Situ Assay Products

Orthologs for IGFN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGFN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Igfn1 35
  • 69.77 (n)
  • 59.55 (a)
Igfn1 16
Igfn1 36
  • 57 (a)
(Pan troglodytes)
Mammalia IGFN1 35
  • 97.84 (n)
  • 96.43 (a)
(Rattus norvegicus)
Mammalia Igfn1 35
  • 66.84 (n)
  • 55.68 (a)
(Bos Taurus)
Mammalia IGFN1 36
  • 55 (a)
(Canis familiaris)
Mammalia -- 36
  • 65 (a)
-- 36
  • 65 (a)
(Monodelphis domestica)
Mammalia IGFN1 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia IGFN1 36
  • 61 (a)
(Gallus gallus)
Aves IGFN1 36
  • 46 (a)
(Anolis carolinensis)
Reptilia IGFN1 36
  • 49 (a)
(Danio rerio)
Actinopterygii LOC100331959 35
  • 51.35 (n)
  • 41.22 (a)
IGFN1 (2 of 4) 36
  • 37 (a)
IGFN1 (3 of 4) 36
  • 35 (a)
IGFN1 (4 of 4) 36
  • 38 (a)
igfn1.1 36
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14964 36
  • 9 (a)
sls 36
  • 2 (a)
Species with no ortholog for IGFN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFN1 Gene

Gene Tree for IGFN1 (if available)
Gene Tree for IGFN1 (if available)

Paralogs for IGFN1 Gene

Paralogs for IGFN1 Gene

(2) SIMAP similar genes for IGFN1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IGFN1: view

Variants for IGFN1 Gene

Sequence variations from dbSNP and Humsavar for IGFN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6690992 - 201,225,875(+) TGGGA(C/T)GGTGA nc-transcript-variant, reference, missense
rs3738270 - 201,225,991(+) GCATC(C/T)ACACC nc-transcript-variant, downstream-variant-500B, reference, missense
rs12466 -- 201,228,680(-) CCTGA(A/T)GCGAA nc-transcript-variant, utr-variant-3-prime
rs14061 -- 201,228,653(+) ACCCT(C/T)ACCAT nc-transcript-variant, utr-variant-3-prime
rs831750 -- 201,190,333(-) CAGGA(A/G)GGAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IGFN1 Gene

Variant ID Type Subtype PubMed ID
nsv428301 CNV Gain 18775914
esv25305 CNV Gain 19812545
esv2721406 CNV Deletion 23290073
esv1570400 CNV Deletion 17803354
esv1754216 CNV Insertion 17803354
esv2721417 CNV Deletion 23290073
nsv518716 CNV Loss 19592680

Variation tolerance for IGFN1 Gene

Gene Damage Index Score: 23.83; 99.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFN1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFN1 Gene

Disorders for IGFN1 Gene

Relevant External Links for IGFN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGFN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGFN1 Gene

Publications for IGFN1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Translation elongation factor eEF1A binds to a novel myosin binding protein-C-like protein. (PMID: 18756455) Mansilla F. … Knudsen C.R. (J. Cell. Biochem. 2008) 3
  4. Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres. (PMID: 15385448) Beatham J. … Blanco G. (Hum. Mol. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for IGFN1 Gene

Sources for IGFN1 Gene