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Aliases for IGFLR1 Gene

Aliases for IGFLR1 Gene

  • IGF Like Family Receptor 1 2 3 5
  • Transmembrane Protein 149 2 3 4
  • TMEM149 3 4
  • U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like 4 2
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like 4 4
  • IGF-Like Family Receptor 1 3
  • U2AF1L4 4

External Ids for IGFLR1 Gene

Previous HGNC Symbols for IGFLR1 Gene

  • U2AF1L4
  • TMEM149

Previous GeneCards Identifiers for IGFLR1 Gene

  • GC19M036231
  • GC19M036361
  • GC19M036542
  • GC19M037060
  • GC19M035771
  • GC19M035910
  • GC19M035936
  • GC19M036801
  • GC19M037404

Summaries for IGFLR1 Gene

GeneCards Summary for IGFLR1 Gene

IGFLR1 (IGF Like Family Receptor 1) is a Protein Coding gene. Diseases associated with IGFLR1 include Skin Conditions.

UniProtKB/Swiss-Prot for IGFLR1 Gene

  • Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFLR1 Gene

Genomics for IGFLR1 Gene

Regulatory Elements for IGFLR1 Gene

Enhancers for IGFLR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G035783 1.3 FANTOM5 Ensembl ENCODE 11.9 -42.0 -42034 2.3 CTCF KLF1 SAP130 ARID4B RAD21 RARA ZFHX2 GLIS2 POLR2A PATZ1 U2AF1L4 ENSG00000267049 LINC01529 IGFLR1 UPK1A GAPDHS ETV2 ARHGAP33 WDR62
GH19G035316 2 FANTOM5 Ensembl ENCODE dbSUPER 2.5 +423.8 423766 5.0 HDGF PKNOX1 FOXA2 MLX SIN3A ZNF2 ZBTB7B SLC30A9 ZNF766 FOS MAG KMT2B ZNF792 TMEM147-AS1 HAUS5 CD22 FFAR3 FFAR2 USF2 FXYD5
GH19G035897 1.8 FANTOM5 ENCODE dbSUPER 2.7 -161.6 -161605 13.0 CREB3L1 FEZF1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ZFP41 TMEM147-AS1 ZNF345 ZNF850 ZNF567 ZNF529 RBM42 KMT2B ZFP14 ZNF260 ZNF792
GH19G035927 1.7 FANTOM5 Ensembl ENCODE 2.7 -188.0 -187981 5.2 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF850 ZNF792 ZNF345 KMT2B ZNF567 HAUS5 TMEM147-AS1 TYROBP RBM42 APLP1
GH19G035910 1.3 FANTOM5 Ensembl ENCODE 3.5 -169.1 -169148 1.6 CTCF NFIB RAD21 ZNF121 ZNF366 ZBTB48 ZNF547 SCRT2 ZNF600 PRDM10 LRFN3 ZNF567 ZNF345 KIRREL2 NPHS1 RBM42 ZNF850 APLP1 IGFLR1 TYROBP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGFLR1 on UCSC Golden Path with GeneCards custom track

Promoters for IGFLR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109058 1553 1401 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for IGFLR1 Gene

Chromosome:
19
Start:
35,738,801 bp from pter
End:
35,742,453 bp from pter
Size:
3,653 bases
Orientation:
Minus strand

Genomic View for IGFLR1 Gene

Genes around IGFLR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFLR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFLR1 Gene

Proteins for IGFLR1 Gene

  • Protein details for IGFLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H665-IGFR1_HUMAN
    Recommended name:
    IGF-like family receptor 1
    Protein Accession:
    Q9H665
    Secondary Accessions:
    • Q8N5X0

    Protein attributes for IGFLR1 Gene

    Size:
    355 amino acids
    Molecular mass:
    37895 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IGFLR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFLR1 Gene

Post-translational modifications for IGFLR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IGFLR1 Gene

Domains & Families for IGFLR1 Gene

Protein Domains for IGFLR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGFLR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFLR1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for IGFLR1 Gene

Function for IGFLR1 Gene

Molecular function for IGFLR1 Gene

UniProtKB/Swiss-Prot Function:
Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.
UniProtKB/Swiss-Prot Induction:
Up-regulated by the proinflammatory cytokine TNFA and in skin upon tissue inflammation.

Gene Ontology (GO) - Molecular Function for IGFLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21454693
genes like me logo Genes that share ontologies with IGFLR1: view

Phenotypes for IGFLR1 Gene

GenomeRNAi human phenotypes for IGFLR1:
genes like me logo Genes that share phenotypes with IGFLR1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFLR1

CRISPR Products

miRNA for IGFLR1 Gene

miRTarBase miRNAs that target IGFLR1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFLR1 Gene

Localization for IGFLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFLR1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFLR1 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for IGFLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 21454693
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGFLR1: view

Pathways & Interactions for IGFLR1 Gene

SuperPathways for IGFLR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGFLR1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGFLR1 Gene

Drugs & Compounds for IGFLR1 Gene

No Compound Related Data Available

Transcripts for IGFLR1 Gene

Unigene Clusters for IGFLR1 Gene

IGF-like family receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFLR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP10:
SP11: - - -
SP12:

Relevant External Links for IGFLR1 Gene

GeneLoc Exon Structure for
IGFLR1
ECgene alternative splicing isoforms for
IGFLR1

Expression for IGFLR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFLR1 Gene

This gene is overexpressed in Whole Blood (x8.9).

Protein differential expression in normal tissues from HIPED for IGFLR1 Gene

This gene is overexpressed in Urine (49.7) and Adipocyte (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGFLR1 Gene



Protein tissue co-expression partners for IGFLR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGFLR1 Gene:

IGFLR1

SOURCE GeneReport for Unigene cluster for IGFLR1 Gene:

Hs.352548

Evidence on tissue expression from TISSUES for IGFLR1 Gene

  • Intestine(4.3)
  • Eye(4)
genes like me logo Genes that share expression patterns with IGFLR1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFLR1 Gene

Orthologs for IGFLR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFLR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFLR1 34 35
  • 93.08 (n)
cow
(Bos Taurus)
Mammalia IGFLR1 34 35
  • 75.54 (n)
rat
(Rattus norvegicus)
Mammalia Igflr1 34
  • 68.72 (n)
mouse
(Mus musculus)
Mammalia Igflr1 34 16 35
  • 67.4 (n)
dog
(Canis familiaris)
Mammalia IGFLR1 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFLR1 35
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC793825 34
  • 41.69 (n)
igflr1 35
  • 25 (a)
OneToOne
Species where no ortholog for IGFLR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFLR1 Gene

ENSEMBL:
Gene Tree for IGFLR1 (if available)
TreeFam:
Gene Tree for IGFLR1 (if available)

Paralogs for IGFLR1 Gene

Pseudogenes.org Pseudogenes for IGFLR1 Gene

genes like me logo Genes that share paralogs with IGFLR1: view

No data available for Paralogs for IGFLR1 Gene

Variants for IGFLR1 Gene

Sequence variations from dbSNP and Humsavar for IGFLR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000971736 -- 35,740,802(+) ACGCG(G/T)CCCCT intron-variant
rs1001911955 -- 35,740,214(+) TAGTT(A/G)GGCCC intron-variant
rs1002970843 -- 35,739,116(+) TCAGC(C/T)CTCCC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1003090496 -- 35,743,423(+) TGGTG(A/G)CTCAC intron-variant, upstream-variant-2KB
rs1003120808 -- 35,744,197(+) CAGGG(A/G)ACTCA intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IGFLR1 Gene

Variant ID Type Subtype PubMed ID
nsv515536 CNV loss 19592680
nsv579422 CNV loss 21841781
nsv579423 CNV loss 21841781

Variation tolerance for IGFLR1 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFLR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFLR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFLR1 Gene

Disorders for IGFLR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGFLR1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
skin conditions
  • dermatologic disorders
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGFLR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFLR1
genes like me logo Genes that share disorders with IGFLR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFLR1 Gene

Publications for IGFLR1 Gene

  1. Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PMID: 21454693) Lobito A.A. … Gonzalez L.C. (J. Biol. Chem. 2011) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for IGFLR1 Gene

Sources for IGFLR1 Gene

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