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Aliases for IGFLR1 Gene

Aliases for IGFLR1 Gene

  • IGF Like Family Receptor 1 2 3 5
  • Transmembrane Protein 149 2 3 4
  • U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like 4 2 3
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like 4 3 4
  • TMEM149 3 4
  • U2AF1L4 3 4

External Ids for IGFLR1 Gene

Previous HGNC Symbols for IGFLR1 Gene

  • U2AF1L4
  • TMEM149

Previous GeneCards Identifiers for IGFLR1 Gene

  • GC19M036231
  • GC19M036361
  • GC19M036542
  • GC19M037060
  • GC19M035771
  • GC19M035910

Summaries for IGFLR1 Gene

GeneCards Summary for IGFLR1 Gene

IGFLR1 (IGF Like Family Receptor 1) is a Protein Coding gene. Diseases associated with IGFLR1 include skin conditions.

UniProtKB/Swiss-Prot for IGFLR1 Gene

  • Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFLR1 Gene

Genomics for IGFLR1 Gene

Regulatory Elements for IGFLR1 Gene

Enhancers for IGFLR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IGFLR1 on UCSC Golden Path with GeneCards custom track

Promoters for IGFLR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IGFLR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGFLR1 Gene

Chromosome:
19
Start:
35,738,801 bp from pter
End:
35,742,453 bp from pter
Size:
3,653 bases
Orientation:
Minus strand

Genomic View for IGFLR1 Gene

Genes around IGFLR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFLR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFLR1 Gene

Proteins for IGFLR1 Gene

  • Protein details for IGFLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H665-IGFR1_HUMAN
    Recommended name:
    IGF-like family receptor 1
    Protein Accession:
    Q9H665
    Secondary Accessions:
    • Q8N5X0

    Protein attributes for IGFLR1 Gene

    Size:
    355 amino acids
    Molecular mass:
    37895 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IGFLR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFLR1 Gene

Proteomics data for IGFLR1 Gene at MOPED

Post-translational modifications for IGFLR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for IGFLR1 Gene

Domains & Families for IGFLR1 Gene

Protein Domains for IGFLR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGFLR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFLR1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for IGFLR1 Gene

Function for IGFLR1 Gene

Molecular function for IGFLR1 Gene

UniProtKB/Swiss-Prot Function:
Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.
UniProtKB/Swiss-Prot Induction:
Up-regulated by the proinflammatory cytokine TNFA and in skin upon tissue inflammation.

Phenotypes for IGFLR1 Gene

GenomeRNAi human phenotypes for IGFLR1:
genes like me logo Genes that share phenotypes with IGFLR1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFLR1

miRNA for IGFLR1 Gene

miRTarBase miRNAs that target IGFLR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFLR1 Gene

Localization for IGFLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFLR1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFLR1 Gene COMPARTMENTS Subcellular localization image for IGFLR1 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for IGFLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 21454693
genes like me logo Genes that share ontologies with IGFLR1: view

Pathways & Interactions for IGFLR1 Gene

SuperPathways for IGFLR1 Gene

No Data Available

Interacting Proteins for IGFLR1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000246532%0d%0a9606.ENSP00000395219%0d%0a9606.ENSP00000415823%0d%0a9606.ENSP00000344860%0d%0a
Selected Interacting proteins: ENSP00000246532 Q9H665-IGFR1_HUMAN for IGFLR1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for IGFLR1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGFLR1 Gene

Drugs & Compounds for IGFLR1 Gene

No Compound Related Data Available

Transcripts for IGFLR1 Gene

Unigene Clusters for IGFLR1 Gene

IGF-like family receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGFLR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP10:
SP11: - - -
SP12:

Relevant External Links for IGFLR1 Gene

GeneLoc Exon Structure for
IGFLR1
ECgene alternative splicing isoforms for
IGFLR1

Expression for IGFLR1 Gene

mRNA expression in normal human tissues for IGFLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFLR1 Gene

This gene is overexpressed in Whole Blood (x8.9).

Protein differential expression in normal tissues from HIPED for IGFLR1 Gene

This gene is overexpressed in Urine (49.7) and Adipocyte (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGFLR1 Gene



SOURCE GeneReport for Unigene cluster for IGFLR1 Gene Hs.352548

genes like me logo Genes that share expression patterns with IGFLR1: view

Protein tissue co-expression partners for IGFLR1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IGFLR1 Gene

Orthologs for IGFLR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFLR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IGFLR1 35
  • 75.54 (n)
  • 68.84 (a)
IGFLR1 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igflr1 35
  • 67.4 (n)
  • 60.82 (a)
Igflr1 16
Igflr1 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IGFLR1 35
  • 93.08 (n)
  • 91.02 (a)
IGFLR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igflr1 35
  • 68.72 (n)
  • 62.34 (a)
dog
(Canis familiaris)
Mammalia IGFLR1 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFLR1 36
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC793825 35
  • 41.69 (n)
  • 33.11 (a)
igflr1 36
  • 25 (a)
OneToOne
Species with no ortholog for IGFLR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFLR1 Gene

ENSEMBL:
Gene Tree for IGFLR1 (if available)
TreeFam:
Gene Tree for IGFLR1 (if available)

Paralogs for IGFLR1 Gene

Pseudogenes.org Pseudogenes for IGFLR1 Gene

genes like me logo Genes that share paralogs with IGFLR1: view

No data available for Paralogs for IGFLR1 Gene

Variants for IGFLR1 Gene

Sequence variations from dbSNP and Humsavar for IGFLR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs34562867 - 35,739,866(-) TCTGC(A/C/T)GGCCC reference, missense
rs7257233 -- 35,741,470(+) ataag(A/C)caatg intron-variant
rs12978576 -- 35,741,425(+) TCTGC(C/G)GTGTC intron-variant
rs12978584 -- 35,741,431(+) GTGTC(C/T)TCACC intron-variant
rs72464368 -- 35,741,658(+) TTACA(-/AA)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFLR1 Gene

Variant ID Type Subtype PubMed ID
dgv3852n71 CNV Loss 21882294
dgv3853n71 CNV Loss 21882294
nsv515536 CNV Loss 19592680

Variation tolerance for IGFLR1 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFLR1 Gene

HapMap Linkage Disequilibrium report
IGFLR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFLR1 Gene

Disorders for IGFLR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGFLR1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
skin conditions
  • dermatologic disorders
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGFLR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFLR1
genes like me logo Genes that share disorders with IGFLR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFLR1 Gene

Publications for IGFLR1 Gene

  1. Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PMID: 21454693) Lobito A.A. … Gonzalez L.C. (J. Biol. Chem. 2011) 2 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for IGFLR1 Gene

Sources for IGFLR1 Gene

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