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Aliases for IGFL4 Gene

Aliases for IGFL4 Gene

  • IGF-Like Family Member 4 2 3

External Ids for IGFL4 Gene

Previous GeneCards Identifiers for IGFL4 Gene

  • GC19M051317
  • GC00U921541
  • GC19M051234
  • GC19M046543
  • GC19M042971

Summaries for IGFL4 Gene

Entrez Gene Summary for IGFL4 Gene

  • IGFL4 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IGFL4 Gene

IGFL4 (IGF-Like Family Member 4) is a Protein Coding gene. An important paralog of this gene is IGFL2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFL4 Gene

Genomics for IGFL4 Gene

Regulatory Elements for IGFL4 Gene

Genomic Location for IGFL4 Gene

46,039,748 bp from pter
46,077,118 bp from pter
37,371 bases
Minus strand

Genomic View for IGFL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGFL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFL4 Gene

Proteins for IGFL4 Gene

  • Protein details for IGFL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin growth factor-like family member 4
    Protein Accession:
    Secondary Accessions:

    Protein attributes for IGFL4 Gene

    124 amino acids
    Molecular mass:
    13885 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGFL4 Gene

Proteomics data for IGFL4 Gene at MOPED

Post-translational modifications for IGFL4 Gene

Other Protein References for IGFL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFL4 Gene

Domains for IGFL4 Gene

Protein Domains for IGFL4 Gene


Suggested Antigen Peptide Sequences for IGFL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IGFL family.
  • Belongs to the IGFL family.
genes like me logo Genes that share domains with IGFL4: view

No data available for Gene Families for IGFL4 Gene

Function for IGFL4 Gene

Gene Ontology (GO) - Molecular Function for IGFL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGFL4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFL4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFL4 Gene

Localization for IGFL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFL4 Gene


Subcellular locations from

Jensen Localization Image for IGFL4 Gene COMPARTMENTS Subcellular localization image for IGFL4 gene
Compartment Confidence
extracellular 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGFL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IGFL4: view

Pathways for IGFL4 Gene

SuperPathways for IGFL4 Gene

No Data Available

Interacting Proteins for IGFL4 Gene

Gene Ontology (GO) - Biological Process for IGFL4 Gene


No data available for Pathways by source for IGFL4 Gene

Transcripts for IGFL4 Gene

mRNA/cDNA for IGFL4 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFL4 Gene

IGF-like family member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFL4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFL4 Gene

No ASD Table

Relevant External Links for IGFL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGFL4 Gene

mRNA expression in normal human tissues for IGFL4 Gene

mRNA differential expression in normal tissues according to GTEx for IGFL4 Gene

This gene is overexpressed in Brain - Cortex (5.1) and Brain - Frontal Cortex (BA9) (4.5).

Protein differential expression in normal tissues for IGFL4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGFL4 Gene

SOURCE GeneReport for Unigene cluster for IGFL4 Gene Hs.531310

mRNA Expression by UniProt/SwissProt for IGFL4 Gene

Tissue specificity: Detected in the cerebellum.
genes like me logo Genes that share expressions with IGFL4: view

Expression partners for IGFL4 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IGFL4 Gene

Orthologs for IGFL4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for IGFL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGFL4 36
  • 64 (a)
Species with no ortholog for IGFL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFL4 Gene

Gene Tree for IGFL4 (if available)
Gene Tree for IGFL4 (if available)

Paralogs for IGFL4 Gene

Paralogs for IGFL4 Gene

(3) SIMAP similar genes for IGFL4 Gene using alignment to 2 proteins: Pseudogenes for IGFL4 Gene

genes like me logo Genes that share paralogs with IGFL4: view

Variants for IGFL4 Gene

Sequence variations from dbSNP and Humsavar for IGFL4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs756401 -- 46,039,991(+) AGCAG(C/T)GGCGG intron-variant
rs10408869 -- 46,042,743(+) AATAA(C/T)AGGAT upstream-variant-2KB
rs10412490 - 46,040,413(+) GTCTA(A/G)GATCT missense, reference
rs28396657 -- 46,039,954(+) AGAAG(C/T)GGGAG intron-variant
rs28670451 -- 46,039,451(+) GATGG(A/G)GATGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IGFL4 Gene

Variant ID Type Subtype PubMed ID
nsv912175 CNV Loss 21882294
nsv912176 CNV Gain 21882294

Relevant External Links for IGFL4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFL4 Gene

Disorders for IGFL4 Gene

No disorders were found for IGFL4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for IGFL4 Gene

Publications for IGFL4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3
  2. IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PMID: 16890402) Emtage P. … Tang Y.T. (Genomics 2006) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  4. Role of mercury (Hg) in resistant infections & effective treatment of Chlamydia trachomatis and Herpes family viral infections (and potential treatment for cancer) by removing localized Hg deposits with Chinese parsley and delivering effective antibiotics using various drug uptake enhancement methods. (PMID: 8686573) Omura Y. … Beckman S.L. (Acupunct Electrother Res 1995) 23
  5. Chemical synthesis of a Zwitterhormon, insulaxin, and of a relaxin-like bombyxin derivative. (PMID: 8703947) BA1llesbach E.E. … Schwabe C. (Biochemistry 1996) 23

Products for IGFL4 Gene

Sources for IGFL4 Gene

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