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Aliases for IGFL4 Gene

Aliases for IGFL4 Gene

  • IGF Like Family Member 4 2 3 5

External Ids for IGFL4 Gene

Previous GeneCards Identifiers for IGFL4 Gene

  • GC19M051317
  • GC00U921541
  • GC19M051234
  • GC19M046543
  • GC19M042971

Summaries for IGFL4 Gene

Entrez Gene Summary for IGFL4 Gene

  • IGFL4 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IGFL4 Gene

IGFL4 (IGF Like Family Member 4) is a Protein Coding gene. An important paralog of this gene is IGFL3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFL4 Gene

Genomics for IGFL4 Gene

Regulatory Elements for IGFL4 Gene

Enhancers for IGFL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F045952 0.9 Ensembl ENCODE 24.7 +122.4 122430 4.7 ATF1 ZNF133 ARID4B SIN3A GLI4 ZNF2 GLIS2 CBX5 ZNF143 SP3 IGFL4 CCDC61 LOC105372421 PPP5D1 MYPOP MIR769 PGLYRP1 FOXA3 SYMPK HIF3A
GH19F045466 0.4 ENCODE 20.4 +608.0 608022 4.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF143 ZNF416 ZNF207 FOS ZNF180 CCDC61 FBXO46 CD3EAP ENSG00000266958 IGFL4 RPS16P9 ENSG00000267614 ENSG00000269148 ENSG00000268810
GH19F046218 0.2 ENCODE 14.7 -141.2 -141221 0.2 ELF3 SIN3A ZSCAN9 CHAMP1 ZNF143 EGR2 THAP11 KLF11 MIER1 MIER2 IGFL4 LOC105372421 PPP5D1 RPL12P41 LOC93429
GH19F046221 0.8 Ensembl ENCODE 14.7 -145.1 -145074 1.3 KLF1 TEAD4 SIN3A ZIC2 CTBP1 POLR2A RCOR1 ZNF600 MAFK TCF7L2 IGFL4 LOC105372421 LOC93429 PPP5D1 RPL12P41 PIR58292 IGFL1
GH19F045715 0.2 ENCODE 14.6 +359.5 359529 3.4 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 YY1 ZNF143 FOS LOC105372418 CCDC61 FBXO46 IGFL4 LOC105372421 ENSG00000266958 ENSG00000269148 QPCTL SNRPD2 PPP5D1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGFL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGFL4 Gene

46,039,748 bp from pter
46,077,118 bp from pter
37,371 bases
Minus strand

Genomic View for IGFL4 Gene

Genes around IGFL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFL4 Gene

Proteins for IGFL4 Gene

  • Protein details for IGFL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin growth factor-like family member 4
    Protein Accession:

    Protein attributes for IGFL4 Gene

    124 amino acids
    Molecular mass:
    13885 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGFL4 Gene

Post-translational modifications for IGFL4 Gene

  • Glycosylation at Asn 57 and Asn 84

Other Protein References for IGFL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFL4 Gene

Domains & Families for IGFL4 Gene

Protein Domains for IGFL4 Gene


Suggested Antigen Peptide Sequences for IGFL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IGFL family.
  • Belongs to the IGFL family.
genes like me logo Genes that share domains with IGFL4: view

No data available for Gene Families for IGFL4 Gene

Function for IGFL4 Gene

Phenotypes for IGFL4 Gene

GenomeRNAi human phenotypes for IGFL4:
genes like me logo Genes that share phenotypes with IGFL4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFL4 Gene

Localization for IGFL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFL4 Gene


Subcellular locations from

Jensen Localization Image for IGFL4 Gene COMPARTMENTS Subcellular localization image for IGFL4 gene
Compartment Confidence
extracellular 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGFL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IGFL4: view

Pathways & Interactions for IGFL4 Gene

SuperPathways for IGFL4 Gene

No Data Available

Interacting Proteins for IGFL4 Gene

Gene Ontology (GO) - Biological Process for IGFL4 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGFL4 Gene

Transcripts for IGFL4 Gene

mRNA/cDNA for IGFL4 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFL4 Gene

IGF-like family member 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFL4 Gene

No ASD Table

Relevant External Links for IGFL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGFL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGFL4 Gene

mRNA differential expression in normal tissues according to GTEx for IGFL4 Gene

This gene is overexpressed in Brain - Cortex (x5.1) and Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for IGFL4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGFL4 Gene

Protein tissue co-expression partners for IGFL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGFL4 Gene:


SOURCE GeneReport for Unigene cluster for IGFL4 Gene:


mRNA Expression by UniProt/SwissProt for IGFL4 Gene:

Tissue specificity: Detected in the cerebellum.
genes like me logo Genes that share expression patterns with IGFL4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IGFL4 Gene

Orthologs for IGFL4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for IGFL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGFL4 35
  • 64 (a)
Species where no ortholog for IGFL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFL4 Gene

Gene Tree for IGFL4 (if available)
Gene Tree for IGFL4 (if available)

Paralogs for IGFL4 Gene

Paralogs for IGFL4 Gene

(3) SIMAP similar genes for IGFL4 Gene using alignment to 2 proteins: Pseudogenes for IGFL4 Gene

genes like me logo Genes that share paralogs with IGFL4: view

Variants for IGFL4 Gene

Sequence variations from dbSNP and Humsavar for IGFL4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10408104 -- 46,042,929(+) ctcac(G/T)ttctg upstream-variant-2KB
rs10408869 -- 46,042,743(+) AATAA(C/T)AGGAT upstream-variant-2KB
rs10412490 -- 46,040,413(+) GTCTA(A/C/G)GATCT reference, missense
rs10418824 -- 46,040,723(+) GCTTG(A/G)CAGGT intron-variant
rs10518266 -- 46,041,053(+) TTACC(A/G)CCATT upstream-variant-2KB

Variation tolerance for IGFL4 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGFL4 Gene

Disorders for IGFL4 Gene

Relevant External Links for IGFL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGFL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGFL4 Gene

Publications for IGFL4 Gene

  1. IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PMID: 16890402) Emtage P. … Tang Y.T. (Genomics 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  4. Chemical synthesis of a Zwitterhormon, insulaxin, and of a relaxin-like bombyxin derivative. (PMID: 8703947) BA1llesbach E.E. … Schwabe C. (Biochemistry 1996) 22 64
  5. Role of mercury (Hg) in resistant infections & effective treatment of Chlamydia trachomatis and Herpes family viral infections (and potential treatment for cancer) by removing localized Hg deposits with Chinese parsley and delivering effective antibiotics using various drug uptake enhancement methods. (PMID: 8686573) Omura Y. … Beckman S.L. (Acupunct Electrother Res 1995) 22 64

Products for IGFL4 Gene

Sources for IGFL4 Gene

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