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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGFL4 Gene

protein-coding   GIFtS: 35
GCID: GC19M046543

IGF-Like Family Member 4

Microbiology & Infectious Diseases Congress
  Search for IGFL4
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
IGF-Like Family Member 41 2
Insulin Growth Factor-Like Family Member 42

External Ids:    HGNC: 329311   Entrez Gene: 4448822   Ensembl: ENSG000002048697   OMIM: 6105475   UniProtKB: Q6B9Z13   

Export aliases for IGFL4 gene to outside databases

Previous GC identifers: GC19M051317 GC00U921541 GC19M051234 GC19M042971


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGFL4 Gene:
IGFL4 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play
critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et
al., 2006 (PubMed 16890402)).(supplied by OMIM, Mar 2008)

GeneCards Summary for IGFL4 Gene: 
IGFL4 (IGF-like family member 4) is a protein-coding gene. An important paralog of this gene is IGFL2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGFL4 gene promoter:
         GR   SEF-1 (1)   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGFL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

IGFL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFL4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M046543:  view genomic region     (about GC identifiers)

Start:
46,543,006 bp from pter      End:
46,580,376 bp from pter
Size:
37,371 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IGFL4_HUMAN, Q6B9Z1 (See protein sequence)
Recommended Name: Insulin growth factor-like family member 4 precursor  
Size: 124 amino acids; 13885 Da
Subcellular location: Secreted (Potential)

Explore the universe of human proteins at neXtProt for IGFL4: NX_Q6B9Z1

Explore proteomics data for IGFL4 at MOPED 

IGFL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGFL4 Protein Expression

REFSEQ proteins: NP_001002923.1  
ENSEMBL proteins: 
 ENSP00000366926   ENSP00000470169  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005615extracellular space ----

IGFL4 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6B9Z1

UniProtKB/Swiss-Prot: IGFL4_HUMAN, Q6B9Z1
Similarity: Belongs to the IGFL family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGFL4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGFL4

Search CenterWatch for drugs/clinical trials and news about IGFL4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IGFL4 gene: 
NM_001002923.1  

Unigene Cluster for IGFL4:

IGF-like family member 4
Hs.531310
Unigene Representative Sequence: DB463786
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000377697(uc002pdy.1) ENST00000601672 ENST00000595006 ENST00000596694

Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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Additional mRNA sequence: AY672114.1 

1 DOTS entry:

DT.121439508 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGFL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGCCAGATT
IGFL4 Expression
About this image


See IGFL4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.531310

UniProtKB/Swiss-Prot: IGFL4_HUMAN, Q6B9Z1
Tissue specificity: Detected in the cerebellum

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and chimp.

Orthologs for IGFL4 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia IGFL46
IGF-like family member 4
63(a)
1 ↔ 1
19(51168587-51169376)


ENSEMBL Gene Tree for IGFL4 (if available)
TreeFam Gene Tree for IGFL4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGFL4 gene
IGFL22  IGFL12  IGFL32  
3 SIMAP similar genes for IGFL4 using alignment to 2 protein entries:     IGFL4_HUMAN (see all proteins):
IGFL2    IGFL3    IGFL1

IGFL4 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for IGFL4
PGOHUM00000234360


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/104 SNPs in IGFL4 are shown (see all 104)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1446121001,2
--42974324(+) GAGGTC/TGCCGG 1 -- us2k10--------
rs771998611,2
F--42974328(+) TCGCCG/AGGGCA 1 -- us2k11Minor allele frequency- A:0.01WA 118
rs286704511,2
C--46542709(+) GATGGA/GGATGG 1 -- ds50010--------
rs1479105161,2
C--46543067(+) CTGTC-/ACAACAAC 1 -- cds10--------
rs1119302051,2
C,F--46543068(+) AACAACAA/-AATCA 1 -- cds11Minor allele frequency- -:0.50CSA 4
rs2015828201,2
C--46543103(+) TACCAA/CGTATT 1 -- ut310--------
rs1902784091,2
C--46543124(+) GTGATC/TTGTGA 1 -- ut310--------
rs2002908531,2
C--46543142(+) ACCCCA/GGAACA 1 -- ut310--------
rs283966571,2
C,F,H--46543212(+) AGAAGT/CGGGAG 1 -- int115Minor allele frequency- C:0.07EA NS NA WA CSA EU 2851
rs1828416551,2
C--46543216(+) GTGGGA/GGAGGG 1 -- int10--------

HapMap Linkage Disequilibrium report for IGFL4 (46543006 - 46580376 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for IGFL4:    About this table     
Variant IDTypeSubtypePubMed ID
nsv912175CNV Loss21882294
nsv912176CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGFL4 for disorders           About MalaCards
OMIM gene information: 610547    OMIM disorders: --


IGFL4 for disorders           About GeneDecksing


Export disorders for IGFL4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGFL4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGFL4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PubMed id 16890402)1, 2 Emtage P....Tang Y.T. (2006)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (2004)
  3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
  4. Chemical synthesis of a Zwitterhormon, insulaxin, and of a relaxin-like bombyxin derivative. (PubMed id 8703947)9 Bullesbach E.E....Schwabe C. (1996)
  5. Role of mercury (Hg) in resistant infections & effective treatment of Chlamydia trachomatis and Herpes family viral infections (and potential treatment for cancer) by removing localized Hg deposits with Chinese parsley and delivering effective antibiotics using various drug uptake enhancement methods. (PubMed id 8686573)9 Omura Y. and Beckman S.L. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 444882 HGNC: 32931 Ensembl:ENSG00000204869 euGenes: HUgn444882 ECgene: IGFL4
H-InvDB: IGFL4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGFL4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGFL4 gene:
Search GeneIP for patents involving IGFL4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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