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IGFL4 Gene

protein-coding   GIFtS: 36
GCID: GC19M046543

IGF-Like Family Member 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IGF-Like Family Member 41 2
Insulin Growth Factor-Like Family Member 42

External Ids:    HGNC: 329311   Entrez Gene: 4448822   Ensembl: ENSG000002048697   OMIM: 6105475   UniProtKB: Q6B9Z13   

Export aliases for IGFL4 gene to outside databases

Previous GC identifers: GC19M051317 GC00U921541 GC19M051234 GC19M042971


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGFL4 Gene:
IGFL4 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play
critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et
al., 2006 (PubMed 16890402)).(supplied by OMIM, Mar 2008)

GeneCards Summary for IGFL4 Gene:
IGFL4 (IGF-like family member 4) is a protein-coding gene. An important paralog of this gene is IGFL2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGFL4 gene promoter:
         GR   SEF-1 (1)   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFL4 promoter sequence
   Search Chromatin IP Primers for IGFL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

IGFL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFL4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M046543:  view genomic region     (about GC identifiers)

Start:
46,543,006 bp from pter      End:
46,580,376 bp from pter
Size:
37,371 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IGFL4_HUMAN, Q6B9Z1 (See protein sequence)
Recommended Name: Insulin growth factor-like family member 4 precursor  
Size: 124 amino acids; 13885 Da

Explore the universe of human proteins at neXtProt for IGFL4: NX_Q6B9Z1

Explore proteomics data for IGFL4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn57, Asn84

  • See IGFL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001002923.1  
    ENSEMBL proteins: 
     ENSP00000366926   ENSP00000470169  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q6B9Z1

    UniProtKB/Swiss-Prot: IGFL4_HUMAN, Q6B9Z1
    Similarity: Belongs to the IGFL family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGFL4_HUMAN, Q6B9Z1: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with IGFL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGFL4
    Interactions:

        Search GeneGlobe Interaction Network for IGFL4

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGFL4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IGFL4 gene: 
    NM_001002923.1  

    Unigene Cluster for IGFL4:

    IGF-like family member 4
    Hs.531310
    Unigene Representative Sequence: DB463786
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377697(uc002pdy.1) ENST00000601672 ENST00000595006 ENST00000596694

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    Additional mRNA sequence: AY672114.1 

    1 DOTS entry:

    DT.121439508 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGFL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCAGATT
    IGFL4 Expression
    About this image

    IGFL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGFL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531310

    UniProtKB/Swiss-Prot: IGFL4_HUMAN, Q6B9Z1
    Tissue specificity: Detected in the cerebellum

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for IGFL4 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia IGFL46
    IGF-like family member 4
    64(a)
    1 ↔ 1
    19(51168587-51169376)


    ENSEMBL Gene Tree for IGFL4 (if available)
    TreeFam Gene Tree for IGFL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGFL4 gene
    IGFL22  IGFL12  IGFL32  
    3 SIMAP similar genes for IGFL4 using alignment to 2 protein entries:     IGFL4_HUMAN (see all proteins):
    IGFL2    IGFL3    IGFL1

    Find genes that share paralogs with IGFL4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IGFL4
    PGOHUM00000234360


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGFL4 (see all 104)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446121001,2
    --42974324(+) GAGGTC/TGCCGG 1 -- us2k10--------
    rs771998611,2
    F--42974328(+) TCGCCG/AGGGCA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs286704511,2
    C--46542709(+) GATGGA/GGATGG 1 -- ds50010--------
    rs1479105161,2
    C--46543067(+) CTGTC-/ACAACAAC 1 -- cds10--------
    rs1119302051,2
    C,F--46543068(+) AACAACAA/-AATCA 1 -- cds11Minor allele frequency- -:0.50CSA 4
    rs2015828201,2
    C--46543103(+) TACCAA/CGTATT 1 -- ut310--------
    rs1902784091,2
    C--46543124(+) GTGATC/TTGTGA 1 -- ut310--------
    rs2002908531,2
    C--46543142(+) ACCCCA/GGAACA 1 -- ut310--------
    rs283966571,2
    C,F,H--46543212(+) AGAAGT/CGGGAG 1 -- int115Minor allele frequency- C:0.07EA NS NA WA CSA EU 2851
    rs1828416551,2
    C--46543216(+) GTGGGA/GGAGGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for IGFL4 (46543006 - 46580376 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IGFL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912175CNV Loss21882294
    nsv912176CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610547    OMIM disorders: --


    Find genes that share disorders with IGFL4           About GenesLikeMe


    Export disorders for IGFL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGFL4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IGFL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PubMed id 16890402)1, 2 Emtage P.... Tang Y.T. (Genomics 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Chemical synthesis of a Zwitterhormon, insulaxin, and of a relaxin-like bombyxin derivative. (PubMed id 8703947)9 BA1llesbach E.E....Schwabe C. (Biochemistry 1996)
    5. Role of mercury (Hg) in resistant infections &amp; effective treatment of Chlamydia trachomatis and Herpes family viral infections (and potential treatment for cancer) by removing localized Hg deposits with Chinese parsley and delivering effective antibiotics using various drug uptake enhancement methods. (PubMed id 8686573)9 Omura Y. and Beckman S.L. (amp 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 444882 HGNC: 32931 Ensembl:ENSG00000204869 euGenes: HUgn444882 ECgene: IGFL4
    H-InvDB: IGFL4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGFL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGFL4 gene:
    Search GeneIP for patents involving IGFL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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