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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGFL3 Gene

protein-coding   GIFtS: 41
GCID: GC19M046627

IGF-Like Family Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
IGF-Like Family Member 31 2
RPRC4832
UNQ4832
Insulin Growth Factor-Like Family Member 32

External Ids:    HGNC: 329301   Entrez Gene: 3885552   Ensembl: ENSG000001886247   OMIM: 6105465   UniProtKB: Q6UXB13   

Export aliases for IGFL3 gene to outside databases

Previous GC identifers: GC19M051318 GC19M043050


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGFL3 Gene:
IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play
critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et
al., 2006 (PubMed 16890402)).(supplied by OMIM, Mar 2008)

GeneCards Summary for IGFL3 Gene: 
IGFL3 (IGF-like family member 3) is a protein-coding gene. Diseases associated with IGFL3 include testicular disease, and skin conditions. An important paralog of this gene is IGFL2.

UniProtKB/Swiss-Prot: IGFL3_HUMAN, Q6UXB1
Function: Potential ligand of the IGFLR1 cell membrane receptor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGFL3 gene promoter:
         HOXA9   HOXA9B   STAT5B   Max1   USF1   STAT3   Meis-1a   c-Myc   Meis-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGFL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

IGFL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M046627:  view genomic region     (about GC identifiers)

Start:
46,623,328 bp from pter      End:
46,627,931 bp from pter
Size:
4,604 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IGFL3_HUMAN, Q6UXB1 (See protein sequence)
Recommended Name: Insulin growth factor-like family member 3 precursor  
Size: 125 amino acids; 14198 Da
Subcellular location: Secreted (Probable)

Explore the universe of human proteins at neXtProt for IGFL3: NX_Q6UXB1

Explore proteomics data for IGFL3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UXB1

  • IGFL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGFL3 Protein Expression
    REFSEQ proteins: NP_997276.1  
    ENSEMBL proteins: 
     ENSP00000344860  

    Human Recombinant Protein Products for IGFL3: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    IGFL3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6UXB1

    UniProtKB/Swiss-Prot: IGFL3_HUMAN, Q6UXB1
    Similarity: Belongs to the IGFL family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IGFL3_HUMAN, Q6UXB1
    Function: Potential ligand of the IGFLR1 cell membrane receptor

    Phenotypes:
         1 MGI phenotypic allele for Igfl3 (no phenotypes)


    IGFL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Igfl3tm1Lex for IGFL3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGFL3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for IGFL3 (ENSP000003448604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGFLR1ENSP000002465324STRING: ENSP00000246532
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGFL3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGFL3

    2 Novoseek inferred chemical compound relationships for IGFL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 70.9 13 12534932 (1), 18436703 (1), 18062862 (1), 17049842 (1) (see all 10)
    phthalate 54.3 1 17258888 (1)

    Search CenterWatch for drugs/clinical trials and news about IGFL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IGFL3 gene: 
    NM_207393.1  

    Unigene Cluster for IGFL3:

    IGF-like family member 3
    Hs.365496  [show with all ESTs]
    Unigene Representative Sequence: BX090433
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000341415(uc002pea.1)
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: IGFL3 (NM_207393)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFL3
    Sirion Biotech Customized lentivirus for stable overexpression of IGFL3 
                         Customized lentivirus expression plasmids for stable overexpression of IGFL3 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFL3

    Additional mRNA sequence: 

    AY358434.1 AY672113.1 BC130593.1 BC130597.1 

    1 DOTS entry:

    DT.404694 

    11 AceView cDNA sequences:

    AA025266 NM_207393 BX090433 BE122850 AY358434 BU624416 AA024389 AY672113 
    BU628572 BQ771506 AW016901 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGFL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCCACGAT
    IGFL3 Expression
    About this image


    See IGFL3 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.365496

    UniProtKB/Swiss-Prot: IGFL3_HUMAN, Q6UXB1
    Tissue specificity: Detected in the cerebellum

        SABiosciences Custom PCR Arrays for IGFL3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for IGFL3 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfl31 , 5 IGF-like family member 31, 5 64.22(n)1
    47.71(a)1
      7 (9.15 cM)5
    2329251  NM_001003393.11  NP_001003393.11 
     181764945 


    ENSEMBL Gene Tree for IGFL3 (if available)
    TreeFam Gene Tree for IGFL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGFL3 gene
    IGFL22  IGFL12  IGFL42  
    3 SIMAP similar genes for IGFL3 using alignment to 1 protein entry:     IGFL3_HUMAN:
    IGFL2    IGFL4    IGFL1

    IGFL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/156 SNPs in IGFL3 are shown (see all 156)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444146001,2
    --46622963(+) AATTGG/TGATAA 1 -- ds50010--------
    rs1826467831,2
    --46623076(+) TTGCCA/GGCAAG 1 -- ds50010--------
    rs1511886791,2
    --46623097(+) AGCCCA/GGGTAG 1 -- ds50010--------
    rs2008954521,2
    C--46623351(+) TTTTA-/TTTGCC 1 -- ut310--------
    rs1878370181,2
    --46623504(+) CTCTCC/TGAAGT 1 -- ut310--------
    rs790874941,2
    C,F--46623540(+) TGCTTG/CGTCTC 1 -- ut311Minor allele frequency- C:0.50NA 4
    rs2009021971,2
    --46623547(+) TCTCTC/TCTCCC 1 -- ut310--------
    rs1999137881,2
    --46623562(+) TCTGCC/TGTCTG 1 -- ut310--------
    rs2022199301,2
    --46623581(+) GCCTGC/GGGTTT 1 -- ut310--------
    rs1931784911,2
    C--46623588(+) GTTTTA/TATGGG 2 * L --0--------

    HapMap Linkage Disequilibrium report for IGFL3 (46623328 - 46627931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for IGFL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664945CNV Deletion23128226
    esv2718646CNV Deletion23290073
    dgv591n67CNV Loss20364138
    nsv498902CNV Loss21111241
    nsv828567CNV Loss20364138
    esv28290CNV Loss19812545
    nsv528826CNV Gain19592680
    nsv912176CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610546    OMIM disorders: --

    12 diseases for IGFL3:    About MalaCards
    testicular disease    skin conditions    cryptorchidism    hyperandrogenism
    klinefelter's syndrome    male infertility    polycystic ovary syndrome    infertility
    diabetes mellitus    hepatitis b    obesity    hepatitis


    IGFL3 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for IGFL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testicular dysgenesis 92.8 1 16687567 (1)
    cryptorchidism 88.7 5 17028442 (1), 18436703 (1), 17437853 (1), 18062862 (1) (see all 5)
    klinefelters syndrome 76 2 18436703 (1), 16926256 (1)
    testicular diseases 74.5 2 15755855 (2)
    hyperandrogenism 46 1 17356050 (1)


    Export disorders for IGFL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGFL3 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with IGFL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PubMed id 16890402)1, 2 Emtage P....Tang Y.T. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (2004)
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PubMed id 21454693)2 Lobito A.A.... Gonzalez L.C. (2011)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Novel mutations involving the INSL3 gene associated with cryptorchidism. (PubMed id 17437853)9 El Houate B....McElreavey K. (2007)
    9. Biology of insulin-like factor 3 in human reproductio n. (PubMed id 19329805)9 Ivell R. and Anand-Ivell R. (2009)
    10. Insulin-like factor 3 as a marker of testicular funct ion in obese men. (PubMed id 19226271)9 Foresta C....Ferlin A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388555 HGNC: 32930 AceView: IGFL3 Ensembl:ENSG00000188624 euGenes: HUgn388555
    ECgene: IGFL3 H-InvDB: IGFL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGFL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGFL3 gene:
    Search GeneIP for patents involving IGFL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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