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Aliases for IGFL3 Gene

Aliases for IGFL3 Gene

  • IGF-Like Family Member 3 2 3
  • RPRC483 3
  • UNQ483 3

External Ids for IGFL3 Gene

Previous GeneCards Identifiers for IGFL3 Gene

  • GC19M051318
  • GC19M046627
  • GC19M043050

Summaries for IGFL3 Gene

Entrez Gene Summary for IGFL3 Gene

  • IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IGFL3 Gene

IGFL3 (IGF-Like Family Member 3) is a Protein Coding gene. Diseases associated with IGFL3 include skin conditions and testicular disease. An important paralog of this gene is IGFL2.

UniProtKB/Swiss-Prot for IGFL3 Gene

  • Potential ligand of the IGFLR1 cell membrane receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFL3 Gene

Genomics for IGFL3 Gene

Regulatory Elements for IGFL3 Gene

Genomic Location for IGFL3 Gene

46,119,863 bp from pter
46,124,705 bp from pter
4,843 bases
Minus strand

Genomic View for IGFL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGFL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFL3 Gene

Proteins for IGFL3 Gene

  • Protein details for IGFL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin growth factor-like family member 3
    Protein Accession:

    Protein attributes for IGFL3 Gene

    125 amino acids
    Molecular mass:
    14198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGFL3 Gene

Proteomics data for IGFL3 Gene at MOPED

Post-translational modifications for IGFL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGFL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFL3 Gene

Domains & Families for IGFL3 Gene

Protein Domains for IGFL3 Gene


Suggested Antigen Peptide Sequences for IGFL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IGFL family.
  • Belongs to the IGFL family.
genes like me logo Genes that share domains with IGFL3: view

No data available for Gene Families for IGFL3 Gene

Function for IGFL3 Gene

Molecular function for IGFL3 Gene

UniProtKB/Swiss-Prot Function:
Potential ligand of the IGFLR1 cell membrane receptor.

Phenotypes for IGFL3 Gene

GenomeRNAi human phenotypes for IGFL3:
genes like me logo Genes that share phenotypes with IGFL3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFL3 Gene

Localization for IGFL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFL3 Gene


Subcellular locations from

Jensen Localization Image for IGFL3 Gene COMPARTMENTS Subcellular localization image for IGFL3 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for IGFL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGFL3: view

Pathways & Interactions for IGFL3 Gene

SuperPathways for IGFL3 Gene

No Data Available

Interacting Proteins for IGFL3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000344860 for IGFL3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for IGFL3 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGFL3 Gene

Drugs & Compounds for IGFL3 Gene

(1) Drugs for IGFL3 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453

(1) Additional Compounds for IGFL3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFL3: view

Transcripts for IGFL3 Gene

mRNA/cDNA for IGFL3 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFL3 Gene

IGF-like family member 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFL3 Gene

No ASD Table

Relevant External Links for IGFL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGFL3 Gene

mRNA expression in normal human tissues for IGFL3 Gene

mRNA differential expression in normal tissues according to GTEx for IGFL3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x26.5) and Skin - Not Sun Exposed (Suprapubic) (x25.1).

SOURCE GeneReport for Unigene cluster for IGFL3 Gene Hs.365496

mRNA Expression by UniProt/SwissProt for IGFL3 Gene

Tissue specificity: Detected in the cerebellum.
genes like me logo Genes that share expression patterns with IGFL3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IGFL3 Gene

Orthologs for IGFL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGFL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia IGFL3 35
  • 75.99 (n)
  • 67.8 (a)
IGFL3 36
  • 60 (a)
(Mus musculus)
Mammalia Igfl3 35
  • 64.22 (n)
  • 47.71 (a)
Igfl3 16
Igfl3 36
  • 37 (a)
(Pan troglodytes)
Mammalia IGFL3 35
  • 99.47 (n)
  • 99.2 (a)
IGFL3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100362729 35
  • 66.67 (n)
  • 53.77 (a)
Species with no ortholog for IGFL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFL3 Gene

Gene Tree for IGFL3 (if available)
Gene Tree for IGFL3 (if available)

Paralogs for IGFL3 Gene

Paralogs for IGFL3 Gene

(3) SIMAP similar genes for IGFL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGFL3: view

Variants for IGFL3 Gene

Sequence variations from dbSNP and Humsavar for IGFL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_034012 -

Structural Variations from Database of Genomic Variants (DGV) for IGFL3 Gene

Variant ID Type Subtype PubMed ID
nsv912176 CNV Gain 21882294
nsv528826 CNV Gain 19592680
nsv828567 CNV Loss 20364138
esv28290 CNV Loss 19812545
esv2664945 CNV Deletion 23128226
nsv498902 CNV Loss 21111241
esv2718646 CNV Deletion 23290073
dgv591n67 CNV Loss 20364138

Variation tolerance for IGFL3 Gene

Residual Variation Intolerance Score: 58.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFL3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFL3 Gene

Disorders for IGFL3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IGFL3 Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
skin conditions
  • dermatologic disorders
testicular disease
  • disorder of testis
  • undescended testicles
- elite association
Search IGFL3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGFL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGFL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFL3 Gene

Publications for IGFL3 Gene

  1. Origin, development and regulation of human Leydig cells. (PMID: 20190545) Svechnikov K. … SAPder O. (Horm Res Paediatr 2010) 23 67
  2. Osteoporosis in Klinefelter's syndrome. (PMID: 20348548) Ferlin A. … Foresta C. (Mol. Hum. Reprod. 2010) 23 67
  3. Insulin-like factor 3 as a marker of testicular function in obese men. (PMID: 19226271) Foresta C. … Ferlin A. (Clin. Endocrinol. (Oxf) 2009) 23 67
  4. Peripheral insulin-like factor 3 concentrations are reduced in men with type 2 diabetes mellitus: effect of glycemic control and visceral adiposity on Leydig cell function. (PMID: 19755411) Ermetici F. … Corbetta S. (Eur. J. Endocrinol. 2009) 23 67
  5. Endocrinology of male puberty. (PMID: 19104233) Lewis K. … Lee P.A. (Curr Opin Endocrinol Diabetes Obes 2009) 23 67

Products for IGFL3 Gene

Sources for IGFL3 Gene

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