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Aliases for IGFL3 Gene

Aliases for IGFL3 Gene

  • IGF Like Family Member 3 2 3 5
  • Insulin Growth Factor-Like Family Member 3 3
  • RPRC483 3
  • UNQ483 3

External Ids for IGFL3 Gene

Previous GeneCards Identifiers for IGFL3 Gene

  • GC19M051318
  • GC19M046627
  • GC19M043050

Summaries for IGFL3 Gene

Entrez Gene Summary for IGFL3 Gene

  • IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IGFL3 Gene

IGFL3 (IGF Like Family Member 3) is a Protein Coding gene. Diseases associated with IGFL3 include Cryptorchidism and Skin Conditions. An important paralog of this gene is IGFL2.

UniProtKB/Swiss-Prot for IGFL3 Gene

  • Potential ligand of the IGFLR1 cell membrane receptor.

Additional gene information for IGFL3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFL3 Gene

Genomics for IGFL3 Gene

Regulatory Elements for IGFL3 Gene

Enhancers for IGFL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H046131 1.5 Ensembl ENCODE dbSUPER 12.5 -8.5 -8517 3.7 PKNOX1 ATF1 FEZF1 ELK1 ATF7 SP3 YY2 ZNF518A NFIL3 ZNF300 ZC3H4 CCDC61 LOC93429 ENSG00000269148 ENSG00000268810 FBXO46 IGFL3 SYMPK SLC1A5 PPP5D1
GH19H046077 1.5 Ensembl ENCODE dbSUPER 11.3 +47.0 46986 0.6 ARID4B SIN3A ZNF2 GLIS2 ZNF143 ATF7 YY2 REST MIER2 KAT8 IGFL3 HIF3A FOXA3 SYMPK GC19P046077 LOC400706
GH19H046114 1 ENCODE dbSUPER 12.4 +9.2 9197 1.1 BACH1 BATF ZFHX2 ZSCAN5C FOS ATF7 RUNX3 IKZF2 EGR2 NR2F1 IGFL3 IGFL2 LOC100533846
GH19H046067 1.5 Ensembl ENCODE dbSUPER 7.5 +55.3 55283 3.2 FEZF1 GLIS2 FOS ATF7 SP3 TSHZ1 PPARG ZNF518A NFIL3 MAFF HIF3A IRF2BP1 LOC93429 IGFL3 KLC3 PIR33092 IGFL4
GH19H046295 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -175.8 -175836 9.4 PKNOX1 ZNF133 ARID4B ZNF121 GLIS2 KLF7 SP3 SP5 NFYC REST PPP5C HIF3A ENSG00000269124 FOSB IGFL3 MYPOP IRF2BP1 CCDC8 DACT3 GC19M046308
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGFL3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGFL3 Gene

Genomic Locations for IGFL3 Gene
4,843 bases
Minus strand

Genomic View for IGFL3 Gene

Genes around IGFL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFL3 Gene

Proteins for IGFL3 Gene

  • Protein details for IGFL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin growth factor-like family member 3
    Protein Accession:

    Protein attributes for IGFL3 Gene

    125 amino acids
    Molecular mass:
    14198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGFL3 Gene

Post-translational modifications for IGFL3 Gene

No Post-translational modifications

Other Protein References for IGFL3 Gene

No data available for DME Specific Peptides for IGFL3 Gene

Domains & Families for IGFL3 Gene

Gene Families for IGFL3 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IGFL3 Gene


Suggested Antigen Peptide Sequences for IGFL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IGFL family.
  • Belongs to the IGFL family.
genes like me logo Genes that share domains with IGFL3: view

Function for IGFL3 Gene

Molecular function for IGFL3 Gene

UniProtKB/Swiss-Prot Function:
Potential ligand of the IGFLR1 cell membrane receptor.

Phenotypes From GWAS Catalog for IGFL3 Gene

Gene Ontology (GO) - Molecular Function for IGFL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 21454693
genes like me logo Genes that share ontologies with IGFL3: view

Phenotypes for IGFL3 Gene

GenomeRNAi human phenotypes for IGFL3:
genes like me logo Genes that share phenotypes with IGFL3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFL3 Gene

Localization for IGFL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFL3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFL3 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IGFL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 21454693
genes like me logo Genes that share ontologies with IGFL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGFL3 Gene

Pathways & Interactions for IGFL3 Gene

SuperPathways for IGFL3 Gene

No Data Available

Interacting Proteins for IGFL3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000344860 Q6UXB1-IGFL3_HUMAN for IGFL3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for IGFL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with IGFL3: view

No data available for Pathways by source and SIGNOR curated interactions for IGFL3 Gene

Drugs & Compounds for IGFL3 Gene

(1) Drugs for IGFL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IGFL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFL3: view

Transcripts for IGFL3 Gene

mRNA/cDNA for IGFL3 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFL3 Gene

IGF-like family member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFL3 Gene

No ASD Table

Relevant External Links for IGFL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGFL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFL3 Gene

mRNA differential expression in normal tissues according to GTEx for IGFL3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x26.5) and Skin - Not Sun Exposed (Suprapubic) (x25.1).

NURSA nuclear receptor signaling pathways regulating expression of IGFL3 Gene:


SOURCE GeneReport for Unigene cluster for IGFL3 Gene:


mRNA Expression by UniProt/SwissProt for IGFL3 Gene:

Tissue specificity: Detected in the cerebellum.
genes like me logo Genes that share expression patterns with IGFL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFL3 Gene

Orthologs for IGFL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGFL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGFL3 33 34
  • 99.47 (n)
(Canis familiaris)
Mammalia IGFL3 33 34
  • 75.99 (n)
(Rattus norvegicus)
Mammalia LOC100362729 33
  • 66.67 (n)
(Mus musculus)
Mammalia Igfl3 33 16 34
  • 64.22 (n)
Species where no ortholog for IGFL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFL3 Gene

Gene Tree for IGFL3 (if available)
Gene Tree for IGFL3 (if available)

Paralogs for IGFL3 Gene

Paralogs for IGFL3 Gene

(3) SIMAP similar genes for IGFL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGFL3: view

Variants for IGFL3 Gene

Sequence variations from dbSNP and Humsavar for IGFL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000259991 -- 46,122,517(+) TTTTC(C/T)ATAGT intron-variant
rs1000345773 -- 46,128,643(+) GAATC(A/G)CATTT intron-variant, upstream-variant-2KB
rs1000953312 -- 46,125,678(+) GCTTC(A/C)TTCTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001364786 -- 46,125,274(+) GTGTG(C/G)TTGGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001410496 -- 46,125,089(+) CTTGC(G/T)TCTTC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IGFL3 Gene

Variant ID Type Subtype PubMed ID
nsv978830 CNV duplication 23825009
nsv828567 CNV loss 20364138
nsv528826 CNV gain 19592680
nsv498902 CNV loss 21111241
esv3644520 CNV loss 21293372
esv28290 CNV loss 19812545
esv2718646 CNV deletion 23290073
esv2664945 CNV deletion 23128226
dgv6505n54 CNV loss 21841781
dgv6504n54 CNV loss 21841781
dgv591n67 CNV loss 20364138
dgv225e215 CNV deletion 23714750

Variation tolerance for IGFL3 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFL3 Gene

Disorders for IGFL3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IGFL3 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
  • cryptorchism
skin conditions
  • dermatologic disorders
testicular disease
  • disorder of testis
- elite association - COSMIC cancer census association via MalaCards
Search IGFL3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGFL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGFL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFL3 Gene

Publications for IGFL3 Gene

  1. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. (PMID: 21454693) Lobito AA … Gonzalez LC (The Journal of biological chemistry 2011) 3 4 60
  2. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PMID: 16890402) Emtage P … Tang YT (Genomics 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 60
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 60
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60

Products for IGFL3 Gene

Sources for IGFL3 Gene

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