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Aliases for IGFL2 Gene

Aliases for IGFL2 Gene

  • IGF Like Family Member 2 2 3 5
  • Insulin Growth Factor-Like Family Member 2 3
  • VPRI645 3
  • UNQ645 3

External Ids for IGFL2 Gene

Previous GeneCards Identifiers for IGFL2 Gene

  • GC19P051344
  • GC19P046651
  • GC19P043078
  • GC19P046143

Summaries for IGFL2 Gene

Entrez Gene Summary for IGFL2 Gene

  • IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IGFL2 Gene

IGFL2 (IGF Like Family Member 2) is a Protein Coding gene. Diseases associated with IGFL2 include Skin Conditions. An important paralog of this gene is IGFL3.

UniProtKB/Swiss-Prot for IGFL2 Gene

  • Potential ligand of the IGFLR1 cell membrane receptor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFL2 Gene

Genomics for IGFL2 Gene

Regulatory Elements for IGFL2 Gene

Enhancers for IGFL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G046200 1.5 Ensembl ENCODE dbSUPER 11.3 +124.1 124123 4.0 PKNOX1 ATF1 ARNT AGO1 YY1 TCF12 ZNF121 ZNF766 ELK1 ZNF143 LOC93429 IRF2BP1 IGFL1 IGFL2 HIF3A IGFL2-AS1 IGFL1P1
GH19G046114 1.1 ENCODE dbSUPER 11.6 +37.0 36981 1.1 BACH1 CEBPG ZFHX2 GATA3 EGR1 EED ZSCAN5C FOS RELB CREM IGFL3 IGFL2 LOC100533846
GH19G046110 0.8 dbSUPER 11.6 +33.1 33089 3.1 CBX3 PKNOX1 RB1 ARID4B RAD21 ZNF335 ZNF143 CREM ZNF654 REST IGFL3 IGFL2 LOC100533846 ENSG00000267922
GH19G046117 0.6 ENCODE 11.8 +40.1 40107 1.7 ZNF263 CTCF NFXL1 ZBTB7A NR2F2 JUND MLLT1 PRDM4 IGFL2 IGFL3 LOC100533846
GH19G046078 0.7 ENCODE 0.7 +0.2 220 0.1 CTCF ZNF654 PKNOX1 NRF1 ZHX2 REST ZNF623 RAD21 JUND SMC3 HIF3A SYMPK FOXA3 IGFL2 PIR37387
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGFL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGFL2 Gene

46,078,528 bp from pter
46,195,097 bp from pter
116,570 bases
Plus strand

Genomic View for IGFL2 Gene

Genes around IGFL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFL2 Gene

Proteins for IGFL2 Gene

  • Protein details for IGFL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin growth factor-like family member 2
    Protein Accession:
    Secondary Accessions:
    • E9PAV1
    • Q6B9Z3

    Protein attributes for IGFL2 Gene

    119 amino acids
    Molecular mass:
    13248 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAT77786.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IGFL2 Gene


neXtProt entry for IGFL2 Gene

Post-translational modifications for IGFL2 Gene

No Post-translational modifications

Other Protein References for IGFL2 Gene

No data available for DME Specific Peptides for IGFL2 Gene

Domains & Families for IGFL2 Gene

Protein Domains for IGFL2 Gene


Suggested Antigen Peptide Sequences for IGFL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IGFL family.
  • Belongs to the IGFL family.
genes like me logo Genes that share domains with IGFL2: view

No data available for Gene Families for IGFL2 Gene

Function for IGFL2 Gene

Molecular function for IGFL2 Gene

UniProtKB/Swiss-Prot Function:
Potential ligand of the IGFLR1 cell membrane receptor.

Phenotypes for IGFL2 Gene

GenomeRNAi human phenotypes for IGFL2:
genes like me logo Genes that share phenotypes with IGFL2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFL2 Gene

Localization for IGFL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFL2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFL2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IGFL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGFL2: view

Pathways & Interactions for IGFL2 Gene

SuperPathways for IGFL2 Gene

No Data Available

Interacting Proteins for IGFL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000395219 Q6UWQ7-IGFL2_HUMAN for IGFL2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for IGFL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGFL2 Gene

Transcripts for IGFL2 Gene

Unigene Clusters for IGFL2 Gene

IGF-like family member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFL2 Gene

No ASD Table

Relevant External Links for IGFL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGFL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFL2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x21.9) and Skin - Not Sun Exposed (Suprapubic) (x21.5).

NURSA nuclear receptor signaling pathways regulating expression of IGFL2 Gene:


SOURCE GeneReport for Unigene cluster for IGFL2 Gene:


mRNA Expression by UniProt/SwissProt for IGFL2 Gene:

Tissue specificity: Detected in cerebellum, heart, placenta, spleen, stomach, testis and thymus.
genes like me logo Genes that share expression patterns with IGFL2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFL2 Gene

Orthologs for IGFL2 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for IGFL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGFL2 34 35
  • 97.39 (n)
(Mus musculus)
Mammalia Igfl3 35
  • 34 (a)
Species where no ortholog for IGFL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFL2 Gene

Gene Tree for IGFL2 (if available)
Gene Tree for IGFL2 (if available)

Paralogs for IGFL2 Gene

Paralogs for IGFL2 Gene

(3) SIMAP similar genes for IGFL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IGFL2: view

Variants for IGFL2 Gene

Sequence variations from dbSNP and Humsavar for IGFL2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000022887 -- 46,110,670(+) GTTCA(A/G)TGTTT intron-variant
rs1000033429 -- 46,117,316(+) CTGGC(C/T)TCAAG intron-variant
rs1000060789 -- 46,156,635(+) ACATA(C/T)ATAAA intron-variant
rs1000078441 -- 46,181,601(+) TGACA(C/T)TCCCT intron-variant, upstream-variant-2KB
rs1000086680 -- 46,116,907(+) ATTAT(G/T)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFL2 Gene

Variant ID Type Subtype PubMed ID
dgv147n111 CNV duplication 26073780
dgv665e214 CNV gain 21293372
esv3644523 CNV gain 21293372
esv3893222 CNV gain 25118596
nsv2511 CNV insertion 18451855
nsv458713 CNV gain 19166990
nsv470147 CNV gain 18288195
nsv579886 CNV gain 21841781

Variation tolerance for IGFL2 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFL2 Gene

Disorders for IGFL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGFL2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
skin conditions
  • dermatologic disorders
- elite association - COSMIC cancer census association via MalaCards
Search IGFL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGFL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGFL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFL2 Gene

Publications for IGFL2 Gene

  1. IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PMID: 16890402) Emtage P. … Tang Y.T. (Genomics 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PMID: 21454693) Lobito A.A. … Gonzalez L.C. (J. Biol. Chem. 2011) 4 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for IGFL2 Gene

Sources for IGFL2 Gene

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