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IGFL2 Gene

protein-coding   GIFtS: 43
GCID: GC19P046651

IGF-Like Family Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
IGF-Like Family Member 21 2
UNQ6452
VPRI6452
Insulin Growth Factor-Like Family Member 22

External Ids:    HGNC: 329291   Entrez Gene: 1479202   Ensembl: ENSG000002048667   OMIM: 6105455   UniProtKB: Q6UWQ73   
ORGUL members:         

Export aliases for IGFL2 gene to outside databases

Previous GC identifers: GC19P051344 GC19P043078


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGFL2 Gene:
IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play
critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et
al., 2006 (PubMed 16890402)).(supplied by OMIM, Mar 2008)

GeneCards Summary for IGFL2 Gene:
IGFL2 (IGF-like family member 2) is a protein-coding gene. Diseases associated with IGFL2 include sezary's disease, and mycosis fungoides. An important paralog of this gene is IGFL1.

UniProtKB/Swiss-Prot: IGFL2_HUMAN, Q6UWQ7
Function: Potential ligand of the IGFLR1 cell membrane receptor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGFL2 gene promoter:
         HOXA9B   HOXA9   Max1   Meis-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFL2 promoter sequence
   Search Chromatin IP Primers for IGFL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

IGFL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFL2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046651:  view genomic region     (about GC identifiers)

Start:
46,646,363 bp from pter      End:
46,664,561 bp from pter
Size:
18,199 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IGFL2_HUMAN, Q6UWQ7 (See protein sequence)
Recommended Name: Insulin growth factor-like family member 2 precursor  
Size: 119 amino acids; 13248 Da
Sequence caution: Sequence=AAT77786.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: E9PAV1 Q6B9Z3
Alternative splicing: 2 isoforms:  Q6UWQ7-1   Q6UWQ7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IGFL2: NX_Q6UWQ7

REFSEQ proteins (2 alternative transcripts): 
NP_001002915.2  NP_001128585.1  

ENSEMBL proteins: 
 ENSP00000395219   ENSP00000366922   ENSP00000471085  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q6UWQ7

UniProtKB/Swiss-Prot: IGFL2_HUMAN, Q6UWQ7
Similarity: Belongs to the IGFL family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IGFL2_HUMAN, Q6UWQ7
Function: Potential ligand of the IGFLR1 cell membrane receptor

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IGFL2_HUMAN, Q6UWQ7: Secreted (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

IGFL2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGFL2
Interactions:

    Search GeneGlobe Interaction Network for IGFL2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for IGFL2 (ENSP000003952194) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IGFLR1ENSP000002465324STRING: ENSP00000246532
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IGFL2 gene (2 alternative transcripts): 
NM_001002915.2  NM_001135113.1  

Unigene Cluster for IGFL2:

IGF-like family member 2
Hs.99376  [show with all ESTs]
Unigene Representative Sequence: NM_001002915
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000600243 ENST00000434646(uc002peb.3) ENST00000377693(uc010xxv.2)
ENST00000593592 ENST00000601052
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Additional mRNA sequence: 

AY358692.1 AY672112.1 BC130490.1 BC130492.1 

3 DOTS entries:

DT.92415218  DT.403018  DT.97804276 

19 AceView cDNA sequences:

BM553923 AK093330 AI208507 AY358692 AA456254 AI123266 NM_001002915 AK125754 
AA454642 AY672112 AI263445 BX280651 AI275379 AI168548 AI081371 AI284208 
BE140595 AW009166 AI806131 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IGFL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGAATGACA
IGFL2 Expression
About this image


IGFL2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Bone (Muscoskeletal System)
         HyStem+TGFbeta3+GDF5-induced SK11 cells
 
 Cartilage (Muscoskeletal System)
         HyStem+TGFbeta3+GDF5-induced SK11 cells
IGFL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.99376

UniProtKB/Swiss-Prot: IGFL2_HUMAN, Q6UWQ7
Tissue specificity: Detected in cerebellum, heart, placenta, spleen, stomach, testis and thymus

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for IGFL2 (if available)
TreeFam Gene Tree for IGFL2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IGFL2 gene
IGFL12  IGFL32  IGFL42  
3 SIMAP similar genes for IGFL2 using alignment to 2 protein entries:     IGFL2_HUMAN (see all proteins):
IGFL3    IGFL4    IGFL1

IGFL2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IGFL2 (see all 323)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1828524371,2
C--46649149(+) GTCCTA/GTGTTA 1 -- us2k10--------
rs730480471,2
C,F--46649160(+) GAGATG/ATGATT 1 -- us2k11Minor allele frequency- A:0.07WA 118
rs1399104691,2
--46649465(+) TGACTA/GTCTTT 1 -- us2k10--------
rs1498236761,2
C--46649582(+) TGTCTA/TTCCAT 2 -- us2k10--------
rs1458860311,2
--46649645(+) GATAGC/TGTGAG 2 -- us2k10--------
rs1879224881,2
--46649680(+) AAATTA/GTGTTG 2 -- us2k10--------
rs1911889141,2
--46649688(+) TTGGCC/TATTCT 2 -- us2k10--------
rs3729948611,2
C--46649761(+) GCTTGG/TGTTTG 2 -- us2k10--------
rs1838721591,2
--46649868(+) TTAAGA/GTTTCC 2 -- us2k10--------
rs1879885011,2
--46649920(+) GATTTA/GCAGTA 2 -- us2k10--------

HapMap Linkage Disequilibrium report for IGFL2 (46646363 - 46664561 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for IGFL2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv2511CNV Insertion18451855
nsv470147CNV Gain18288195
nsv912179CNV Gain21882294
nsv458713CNV Gain19166990
dgv3959n71CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610545    OMIM disorders: --

2 diseases for IGFL2:    
About MalaCards
sezary's disease    mycosis fungoides

1 disease from the University of Copenhagen DISEASES database for IGFL2:
Sezary's disease

IGFL2 for disorders           About GeneDecksing


Export disorders for IGFL2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IGFL2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with IGFL2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PubMed id 16890402)1, 2 Emtage P.... Tang Y.T. (Genomics 2006)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  4. Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PubMed id 21454693)2 Lobito A.A.... Gonzalez L.C. (J. Biol. Chem. 2011)
  5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 147920 HGNC: 32929 AceView: IGFL2 Ensembl:ENSG00000204866 euGenes: HUgn147920
ECgene: IGFL2 H-InvDB: IGFL2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IGFL2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IGFL2 gene:
Search GeneIP for patents involving IGFL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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