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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGFL2 Gene

protein-coding GIFtS: 40
GCID: GC19P046651

IGF-like family member 2

Explore 3 diseases affiliated with
IGFL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
IGF-Like Family Member 2¹ ²
UNQ645¹ ²
VPRI645²
Insulin Growth Factor-Like Family Member 2²

External Ids:	HGNC: 32929¹	Entrez Gene: 147920²	Ensembl: ENSG00000204866⁷	OMIM: 610545⁵	UniProtKB: Q6UWQ7³

Export aliases for IGFL2 gene to outside databases

Previous GC identifers: GC19P051344 GC19P043078

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGFL2:

IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical

roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006

(PubMed 16890402)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: IGFL2_HUMAN, Q6UWQ7

Function: Potential ligand of the IGFLR1 cell membrane receptor

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGFL2 gene promoter:
HOXA9B HOXA9 Max1 Meis-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGFL2 promoter sequence

Search SABiosciences Chromatin IP Primers for IGFL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32

IGFL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFL2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P046651: view genomic region (about GC identifiers)

Start:	46,651,039 bp from pter	End:	46,664,561 bp from pter
Size:	13,523 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IGFL2_HUMAN, Q6UWQ7 (See protein sequence)

Recommended Name: Insulin growth factor-like family member 2 precursor

Size: 119 amino acids; 13248 Da

Subcellular location: Secreted (Potential)

Sequence caution: Sequence=AAT77786.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: E9PAV1 Q6B9Z3

Alternative splicing: 2 isoforms: Q6UWQ7-1 Q6UWQ7-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IGFL2: NX_Q6UWQ7

IGFL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001002915.2 NP_001128585.1

ENSEMBL proteins:

ENSP00000366922 ENSP00000395219

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

IGFL2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6UWQ7

UniProtKB/Swiss-Prot: IGFL2_HUMAN, Q6UWQ7

Similarity: Belongs to the IGFL family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IGFL2_HUMAN, Q6UWQ7

Function: Potential ligand of the IGFLR1 cell membrane receptor

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IGFL2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for IGFL2 (ENSP00000395219⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGFLR1	ENSP00000246532⁴	STRING: ENSP00000246532

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for IGFL2 gene (2 alternative transcripts):

NM_001002915.2 NM_001135113.1

Unigene Cluster for IGFL2:

IGF-like family member 2

Hs.99376 [show with all ESTs]

Unigene Representative Sequence: NM_001002915

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377693(uc010xxv.2) ENST00000434646(uc002peb.3)

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Additional cDNA sequence:

AY358692.1 AY672112.1 BC130490.1 BC130492.1

3 DOTS entries:

DT.92415218 DT.403018 DT.97804276

19 AceView cDNA sequences:

AK093330 BM553923 AK125754 AI123266 BX280651 AY672112 AA456254 AI208507

AY358692 AA454642 NM_001002915 AI263445 BE140595 AI081371 AI275379 AI284208

AI168548 AW009166 AI806131

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGFL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAATGACA

About this image

IGFL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IGFL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGFL2

SOURCE GeneReport for Unigene cluster: Hs.99376

UniProtKB/Swiss-Prot: IGFL2_HUMAN, Q6UWQ7

Tissue specificity: Detected in cerebellum, heart, placenta, spleen, stomach, testis and thymus

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for IGFL2 (if available)
TreeFam Gene Tree for IGFL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGFL2 gene

IGFL1² IGFL4² IGFL3²

3 SIMAP similar genes for IGFL2 using alignment to 2 protein entries: IGFL2_HUMAN (see all proteins):

IGFL3 IGFL4 IGFL1

IGFL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182852437^1,2		--	46649149(+)	`GTCCTA/GTGTTA`	1	--	us2k¹		0	--	--	--	--
rs73048047^1,2	C,F,	--	46649160(+)	`GAGATG/ATGATT`	1	--	us2k¹		1		WA	118
rs139910469^1,2		--	46649465(+)	`TGACTA/GTCTTT`	1	--	us2k¹		0	--	--	--	--
rs149823676^1,2		--	46649582(+)	`TGTCTA/TTCCAT`	2	--	us2k¹		0	--	--	--	--
rs145886031^1,2		--	46649645(+)	`GATAGC/TGTGAG`	2	--	us2k¹		0	--	--	--	--
rs187922488^1,2		--	46649680(+)	`AAATTA/GTGTTG`	2	--	us2k¹		0	--	--	--	--
rs191188914^1,2		--	46649688(+)	`TTGGCC/TATTCT`	2	--	us2k¹		0	--	--	--	--
rs183872159^1,2		--	46649868(+)	`TTAAGA/GTTTCC`	2	--	us2k¹		0	--	--	--	--
rs187988501^1,2		--	46649920(+)	`GATTTA/GCAGTA`	2	--	us2k¹		0	--	--	--	--
rs192266017^1,2		--	46649935(+)	`AGTTCA/GGTTTT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IGFL2 (46651039 - 46664561 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IGFL2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGFL2 for disorders           About GeneDecksing

OMIM gene information: 610545    OMIM disorders: --

3 diseases for IGFL2:    About MalaCards

mycosis fungoides skin conditions sezary's disease

1 disease from the University of Copenhagen DISEASES database for IGFL2:

Sezary's disease

Export disorders for IGFL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGFL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGFL2)

Utopia: connect your pdf to the dynamic
world of online information

IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PubMed id 16890402)^{1, 2} Emtage P....Tang Y.T. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 3} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PubMed id 21454693)² Lobito A.A.... Gonzalez L.C. (2011)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 147920	HGNC: 32929	AceView: IGFL2	Ensembl:ENSG00000204866	euGenes: HUgn147920
ECgene: IGFL2	H-InvDB: IGFL2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IGFL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IGFL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IGFL2 gene:
Search GeneIP for patents involving IGFL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IGFL2 gene at Home site.

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IGFL2 Gene

IGF-like family member 2

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for IGFL2 gene

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Export list of displayed genes

IGFL2 Gene

IGF-like family member 2

Aliasesfor IGFL2 gene

Summariesfor IGFL2 gene

Genomic Viewsfor IGFL2 gene

Proteinsfor IGFL2 gene

Protein Domains /Familiesfor IGFL2 gene

Functionfor IGFL2 gene

Pathways & Interactionsfor IGFL2 gene

Drugs & Compoundsfor IGFL2 gene

Transcriptsfor IGFL2 gene

Expression for IGFL2 gene

Orthologsfor IGFL2 gene

Paralogsfor IGFL2 gene

Genomic Variantsfor IGFL2 gene

Disorders / Diseasesfor IGFL2 gene

Publicationsfor IGFL2 gene

External Searches for IGFL2 gene

Genome Databases showing IGFL2 gene

Other Databases showing IGFL2 gene

Specialized Databases showing IGFL2 gene

Intellectual Propertyfor IGFL2 gene

Productsfor IGFL2 gene

View Random Gene

Aliases
for IGFL2 gene

Summaries
for IGFL2 gene

Genomic Views
for IGFL2 gene

Proteins
for IGFL2 gene

Protein Domains /
Families
for IGFL2 gene

Function
for IGFL2 gene

Pathways & Interactions
for IGFL2 gene

Drugs & Compounds
for IGFL2 gene

Transcripts
for IGFL2 gene

Expression
for IGFL2 gene

Orthologs
for IGFL2 gene

Paralogs
for IGFL2 gene

Genomic Variants
for IGFL2 gene

Disorders / Diseases
for IGFL2 gene

Publications
for IGFL2 gene

Intellectual Property
for IGFL2 gene

Products
for IGFL2 gene