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Aliases for IGFL2 Gene

Aliases for IGFL2 Gene

  • IGF-Like Family Member 2 2 3
  • Insulin Growth Factor-Like Family Member 2 3
  • VPRI645 3
  • UNQ645 3

External Ids for IGFL2 Gene

Previous GeneCards Identifiers for IGFL2 Gene

  • GC19P051344
  • GC19P046651
  • GC19P043078

Summaries for IGFL2 Gene

Entrez Gene Summary for IGFL2 Gene

  • IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IGFL2 Gene

IGFL2 (IGF-Like Family Member 2) is a Protein Coding gene. Diseases associated with IGFL2 include skin conditions. An important paralog of this gene is IGFL4.

UniProtKB/Swiss-Prot for IGFL2 Gene

  • Potential ligand of the IGFLR1 cell membrane receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFL2 Gene

Genomics for IGFL2 Gene

Regulatory Elements for IGFL2 Gene

Genomic Location for IGFL2 Gene

Start:
46,143,106 bp from pter
End:
46,161,304 bp from pter
Size:
18,199 bases
Orientation:
Plus strand

Genomic View for IGFL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGFL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFL2 Gene

Proteins for IGFL2 Gene

  • Protein details for IGFL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWQ7-IGFL2_HUMAN
    Recommended name:
    Insulin growth factor-like family member 2
    Protein Accession:
    Q6UWQ7
    Secondary Accessions:
    • E9PAV1
    • Q6B9Z3

    Protein attributes for IGFL2 Gene

    Size:
    119 amino acids
    Molecular mass:
    13248 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAT77786.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IGFL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFL2 Gene

Proteomics data for IGFL2 Gene at MOPED

Post-translational modifications for IGFL2 Gene

No Post-translational modifications

Other Protein References for IGFL2 Gene

No data available for DME Specific Peptides for IGFL2 Gene

Domains for IGFL2 Gene

Protein Domains for IGFL2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for IGFL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWQ7

UniProtKB/Swiss-Prot:

IGFL2_HUMAN :
  • Q6UWQ7
Family:
  • Belongs to the IGFL family.
genes like me logo Genes that share domains with IGFL2: view

No data available for Gene Families for IGFL2 Gene

Function for IGFL2 Gene

Molecular function for IGFL2 Gene

UniProtKB/Swiss-Prot Function: Potential ligand of the IGFLR1 cell membrane receptor.

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IGFL2 Gene

Localization for IGFL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFL2 Gene COMPARTMENTS Subcellular localization image for IGFL2 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for IGFL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGFL2: view

Pathways for IGFL2 Gene

SuperPathways for IGFL2 Gene

No Data Available

Interacting Proteins for IGFL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000395219%0d%0a9606.ENSP00000246532%0d%0a
Selected Interacting proteins: ENSP00000395219 for IGFL2 Gene via STRING

Symbol External ID(s) Details
IGFLR1

Gene Ontology (GO) - Biological Process for IGFL2 Gene

None

No data available for Pathways by source for IGFL2 Gene

Transcripts for IGFL2 Gene

Unigene Clusters for IGFL2 Gene

IGF-like family member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFL2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IGFL2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFL2 Gene

No ASD Table

Relevant External Links for IGFL2 Gene

GeneLoc Exon Structure for
IGFL2
ECgene alternative splicing isoforms for
IGFL2

Expression for IGFL2 Gene

mRNA expression in normal human tissues for IGFL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFL2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (21.9) and Skin - Not Sun Exposed (Suprapubic) (21.5).

SOURCE GeneReport for Unigene cluster for IGFL2 Gene Hs.99376

mRNA Expression by UniProt/SwissProt for IGFL2 Gene

Q6UWQ7-IGFL2_HUMAN
Tissue specificity: Detected in cerebellum, heart, placenta, spleen, stomach, testis and thymus.
genes like me logo Genes that share expressions with IGFL2: view

In Situ Assay Products

No data available for Protein expression for IGFL2 Gene

Orthologs for IGFL2 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for IGFL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFL2 35
  • 97.39 (n)
  • 94.78 (a)
IGFL2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igfl3 36
  • 34 (a)
OneToMany
Species with no ortholog for IGFL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFL2 Gene

ENSEMBL:
Gene Tree for IGFL2 (if available)
TreeFam:
Gene Tree for IGFL2 (if available)

Paralogs for IGFL2 Gene

Paralogs for IGFL2 Gene

Selected SIMAP similar genes for IGFL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IGFL2: view

Variants for IGFL2 Gene

Sequence variations from dbSNP and Humsavar for IGFL2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs968483 -- 46,158,749(+) GGCCA(A/G)TACCC intron-variant
rs1860653 -- 46,153,839(+) tatat(A/T)tTTTt intron-variant
rs1987541 -- 46,158,499(+) CCACC(A/G)CGCCC intron-variant
rs2041990 -- 46,147,067(+) AAAAA(A/G)GGGCT upstream-variant-2KB
rs2270403 -- 46,160,911(+) GGGTC(A/G)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFL2 Gene

Variant ID Type Subtype PubMed ID
nsv2511 CNV Insertion 18451855
dgv3959n71 CNV Gain 21882294
nsv912179 CNV Gain 21882294
nsv470147 CNV Gain 18288195
nsv458713 CNV Gain 19166990

Relevant External Links for IGFL2 Gene

HapMap Linkage Disequilibrium report
IGFL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFL2 Gene

Disorders for IGFL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for IGFL2 Gene including...

Search for IGFL2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for IGFL2 Gene

genes like me logo Genes that share disorders with IGFL2: view

No data available for UniProtKB/Swiss-Prot for IGFL2 Gene

Publications for IGFL2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3
  3. IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PMID: 16890402) Emtage P. … Tang Y.T. (Genomics 2006) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  5. Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PMID: 21454693) Lobito A.A. … Gonzalez L.C. (J. Biol. Chem. 2011) 4

Products for IGFL2 Gene

Sources for IGFL2 Gene

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