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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGFL1 Gene

protein-coding GIFtS: 40
GCID: GC19P046733

IGF-Like Family Member 1

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
IGF-Like Family Member 1¹ ²
APRG644²
UNQ644²
Insulin Growth Factor-Like Family Member 1²

External Ids:	HGNC: 24093¹	Entrez Gene: 374918²	Ensembl: ENSG00000188293⁷	OMIM: 610544⁵	UniProtKB: Q6UW32³

Export aliases for IGFL1 gene to outside databases

Previous GC identifers: GC19P051425 GC19P043160

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGFL1 Gene:

IGFL1 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play

critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et

al., 2006 (PubMed 16890402)).(supplied by OMIM, Mar 2008)

GeneCards Summary for IGFL1 Gene:

IGFL1 (IGF-like family member 1) is a protein-coding gene. Diseases associated with IGFL1 include skin conditions. GO annotations related to this gene include protein binding. An important paralog of this gene is IGFL2.

UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32

Function: Probable ligand of the IGFLR1 cell membrane receptor

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.2 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGFL1 gene promoter:
HTF NRSF form 1 LUN-1 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGFL1 promoter sequence

Search SABiosciences Chromatin IP Primers for IGFL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32

IGFL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFL1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P046733: view genomic region (about GC identifiers)

Start:	46,733,009 bp from pter	End:	46,734,500 bp from pter
Size:	1,492 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32 (See protein sequence)

Recommended Name: Insulin growth factor-like family member 1 precursor

Size: 110 amino acids; 12363 Da

Subunit: Homodimer; disulfide-linked

Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for IGFL1: NX_Q6UW32

Explore proteomics data for IGFL1 at MOPED

IGFL1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_940943.1

ENSEMBL proteins:

ENSP00000415823

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	--

IGFL1 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6UW32

UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32

Similarity: Belongs to the IGFL family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IGFL1_HUMAN, Q6UW32

Function: Probable ligand of the IGFLR1 cell membrane receptor

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

IGFL1 for ontologies About GeneDecksing

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IGFL1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for IGFL1 (Q6UW32¹ ENSP00000415823⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGFLR1	Q9H665¹, ENSP00000246532⁴	EBI-3870426,EBI-3870439 STRING: ENSP00000246532

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGFL1

Search CenterWatch for drugs/clinical trials and news about IGFL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for IGFL1 gene:

NM_198541.1

Unigene Cluster for IGFL1:

IGF-like family member 1

Hs.546554 [show with all ESTs]

Unigene Representative Sequence: BG775668

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000437936(uc002pee.3)

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Additional mRNA sequence:

AY359013.1 AY672111.1

2 DOTS entries:

DT.100049000 DT.405917

18 AceView cDNA sequences:

BU543034 AY672111 AY359013 BG775668 NM_198541 AA456370 BF911380 CA433564

AA455904 BG775059 AA195677 AW265432 AW991605 BF913866 AW265494 BF911379

BG680336 BF914311

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGFL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

See IGFL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGFL1

SOURCE GeneReport for Unigene cluster: Hs.546554

UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32

Tissue specificity: Detected in ovary and spinal cord

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for IGFL1 gene from 1/2 species (see all 2) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
cow (Bos taurus)	Mammalia	IGFL1¹	IGF-like family member 1	77.67(n) 67.92(a)		512788 XM_002695176.2 XP_002695222.1

ENSEMBL Gene Tree for IGFL1 (if available)
TreeFam Gene Tree for IGFL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGFL1 gene

IGFL2² IGFL3² IGFL4²

3 SIMAP similar genes for IGFL1 using alignment to 1 protein entry: IGFL1_HUMAN:

IGFL3 IGFL4 IGFL2

IGFL1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for IGFL1
PGOHUM00000234361 PGOHUM00000234723

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74410617^1,2	C	--	46731046(+)	`CACCAC/TTTGGC`	1	--	us2k¹		0	--	--	--	--
rs147109762^1,2		--	46731077(+)	`AGATAC/TCTAGT`	1	--	us2k¹		0	--	--	--	--
rs138683870^1,2		--	46731121(+)	`TCATAC/TGATAG`	1	--	us2k¹		0	--	--	--	--
rs185393027^1,2		--	46731139(+)	`TAATAA/CTATTC`	1	--	us2k¹		0	--	--	--	--
rs188920260^1,2		--	46731153(+)	`CATTAC/TTTGGA`	1	--	us2k¹		0	--	--	--	--
rs148822732^1,2		--	46731291(+)	`AAATAC/TGGTAA`	1	--	us2k¹		0	--	--	--	--
rs143519221^1,2		--	46731316(+)	`GGAGAA/GTACAC`	1	--	us2k¹		0	--	--	--	--
rs12459553^1,2	C,F,A,H	--	46731463(+)	`ACAAGG/ACTTCA`	1	--	us2k¹		3		NA	124
rs7250001^1,2	C	--	46731484(+)	`ataaaA/TaaTTT`	1	--	us2k¹ tfbs³		0	--	--	--	--
rs141746381^1,2		--	46731503(+)	`GTGTCA/TTAAAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IGFL1 (46733009 - 46734500 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for IGFL1: About this table

Variant ID	Type	Subtype	PubMed ID
dgv3960n71	CNV	Gain	21882294
nsv458714	CNV	Gain	19166990
nsv470147	CNV	Gain	18288195
nsv912179	CNV	Gain	21882294
nsv458713	CNV	Gain	19166990
nsv912180	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 610544 OMIM disorders: --

2 diseases for IGFL1: About MalaCards

skin conditions

IGFL1 for disorders About GeneDecksing

Export disorders for IGFL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGFL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGFL1)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PubMed id 21454693)^{1, 2} Lobito A.A.... Gonzalez L.C. (2011)
IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PubMed id 16890402)^{1, 2} Emtage P....Tang Y.T. (2006)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children. (PubMed id 19147602)¹ Ester W.A....Hokken-Koelega A.C. (2009)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch. (PubMed id 8884603)⁹ Yang S....Goldspink G. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 374918	HGNC: 24093	AceView: IGFL1	Ensembl:ENSG00000188293	euGenes: HUgn374918
ECgene: IGFL1	H-InvDB: IGFL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IGFL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IGFL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IGFL1 gene:
Search GeneIP for patents involving IGFL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL1

	SwitchGear 3'UTR luciferase reporter plasmids for IGFL1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFL1

	inGenious Targeting Laboratory - Custom generated mouse model solutions for IGFL1
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGFL1

Customized:

	lentivirus for stable overexpression of IGFL1
	lentivirus expression plasmids for stable overexpression of IGFL1
	adenovirus for overexpression of IGFL1

LSBio Antibodies in human, mouse, rat for IGFL1

Customized transgenic rodents for:

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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IGFL1 gene at Home site.

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IGFL1 Gene

IGF-Like Family Member 1

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Export list of displayed genes

IGFL1 Gene

IGF-Like Family Member 1

Aliasesfor IGFL1 gene

Summariesfor IGFL1 gene

Genomic Viewsfor IGFL1 gene

Proteinsfor IGFL1 gene

Protein Domains /Familiesfor IGFL1 gene

Functionfor IGFL1 gene

Pathways & Interactionsfor IGFL1 gene

Drugs & Compoundsfor IGFL1 gene

Transcriptsfor IGFL1 gene

Expression for IGFL1 gene

Orthologsfor IGFL1 gene

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Genomic Variantsfor IGFL1 gene

Disorders / Diseasesfor IGFL1 gene

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External Searches for IGFL1 gene

Genome Databases showing IGFL1 gene

Other Databases showing IGFL1 gene

Specialized Databases showing IGFL1 gene

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Aliases
for IGFL1 gene

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for IGFL1 gene

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for IGFL1 gene

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for IGFL1 gene

Protein Domains /
Families
for IGFL1 gene

Function
for IGFL1 gene

Pathways & Interactions
for IGFL1 gene

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for IGFL1 gene

Transcripts
for IGFL1 gene

Expression
for IGFL1 gene

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for IGFL1 gene

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for IGFL1 gene

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for IGFL1 gene

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for IGFL1 gene

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for IGFL1 gene

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for IGFL1 gene

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for IGFL1 gene