IGFL1 Gene
protein-coding GIFtS: 40
GCID: GC19P046733
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IGF-Like Family Member 1
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Aliases
for IGFL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| IGF-Like Family Member 11 2 | | APRG6442 | | UNQ6442 | | Insulin Growth Factor-Like Family Member 12 |
Export aliases for IGFL1 gene to outside databasesPrevious GC identifers: GC19P051425 GC19P043160 |
Summaries
for IGFL1 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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Entrez Gene summary for IGFL1 Gene:
IGFL1 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play
critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et
al., 2006 (PubMed 16890402)).(supplied by OMIM, Mar 2008)
GeneCards Summary for IGFL1 Gene:
IGFL1 (IGF-like family member 1) is a protein-coding gene. An important paralog of this gene is IGFL2.
UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32Function: Probable ligand of the IGFLR1 cell membrane receptor
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Genomic Views
for IGFL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000019.10 NC_018930.2 NT_011109.17
Regulatory elements:
 Regulatory transcription factor binding sites in the IGFL1 gene promoter:
HTF NRSF form 1 LUN-1 NRSF form 2
Other transcription factors
Search Chromatin IP Primers for IGFL1
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32IGFL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P046733: view genomic region
(about GC identifiers)
Start:
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46,733,009 bp from pter |
End:
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46,734,500 bp from pter |
Size:
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1,492 bases |
Orientation:
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plus strand |
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Proteins
for IGFL1 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32 (See
protein sequence)Recommended Name: Insulin growth factor-like family member 1 precursor Size: 110 amino acids; 12363 Da
Subunit: Homodimer; disulfide-linkedExplore the universe of human proteins at neXtProt for IGFL1: NX_Q6UW32
Explore proteomics data for IGFL1 at MOPED
Post-translational modifications:  Glycosylation2 at Asn71
See IGFL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_940943.1
ENSEMBL proteins: ENSP00000415823
IGFL1 Human Recombinant
Protein Products:IGFL1 Antibody
Products:IGFL1 Assay Products: |
Domains /
Families
for IGFL1 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | ProtoNet protein and cluster: Q6UW32 UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32Similarity: Belongs to the IGFL family |
Function
for IGFL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Molecular Function:
UniProtKB/Swiss-Prot Summary: IGFL1_HUMAN, Q6UW32Function: Probable ligand of the IGFLR1 cell membrane receptor Gene Ontology (GO): 1 molecular function term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
IGFL1 for ontologies About GeneDecksing
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for IGFL1
| | | Predesigned siRNA for gene silencing in human, mouse, rat IGFL1 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for IGFL1 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for IGFL1  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL1 |
Localization
for IGFL1 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot IGFL1_HUMAN, Q6UW32: SecretedSubcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
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| extracellular | 5 | | cytosol | 1 | | nucleus | 1 |
Gene Ontology (GO): 1 cellular component term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IDA | -- |
IGFL1 for ontologies About GeneDecksing
|
Pathways & Interactions
for IGFL1 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGFL1
Interactions:
Search GeneGlobe Interaction Network for IGFL1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for IGFL1 (Q6UW321 ENSP000004158234) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for IGFL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
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 Browse compounds at ApexBio
 Browse Tocris compounds for IGFL1
|
Transcripts
for IGFL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for IGFL1 gene: NM_198541.1 Unigene Cluster for IGFL1: IGF-like family member 1 Hs.546554 [show with all ESTs]Unigene Representative Sequence: BG7756681 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000437936(uc002pee.3)
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for IGFL1
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat IGFL1 |
Primer
Products: | | OriGene qPCR primer pairs and template standards for IGFL1
OriGene qSTAR qPCR primer pairs in human, mouse for IGFL1
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IGFL1 | | | QuantiTect SYBR Green Assays in human, mouse, rat IGFL1 | | | QuantiFast Probe-based Assays in human, mouse, rat IGFL1 |
Additional mRNA sequence: AY359013.1 AY672111.1 2 DOTS entries: DT.100049000 DT.405917 18 AceView cDNA sequences: BU543034 BG775059 AA455904 CA433564 AY672111 AA456370 AY359013 BG775668 NM_198541 BF911380 AA195677 AW265432 AW991605 AW265494 BF913866 BF914311 BG680336 BF911379
GeneLoc Exon Structure
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Expression
for IGFL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IGFL1 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image IGFL1 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.546554
UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32Tissue specificity: Detected in ovary and spinal cord
Custom PCR Arrays for IGFL1
Primer
Products: | | OriGene qPCR primer pairs and template standards for IGFL1
OriGene qSTAR qPCR primer pairs in human, mouse for IGFL1
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IGFL1 | | | QuantiTect SYBR Green Assays in human, mouse, rat IGFL1 | | | QuantiFast Probe-based Assays in human, mouse, rat IGFL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL1 |
Orthologs
for IGFL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of mammals.
Orthologs for IGFL1 gene from Selected species (see all 2) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
cow
(Bos taurus) |
Mammalia |
LOC5127881 |
IGF-like family member 1-like |
77.67(n)
67.92(a) |
|
512788 XM_002695176.3 XP_002695222.1 |
ENSEMBL Gene Tree for IGFL1 (if available)
TreeFam Gene Tree for IGFL1 (if available) |
Paralogs
for IGFL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for IGFL1 gene
- IGFL22 IGFL32 IGFL42
3 SIMAP similar genes for IGFL1 using alignment to 1 protein entry: IGFL1_HUMAN:IGFL3 IGFL4 IGFL2
IGFL1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for IGFL1
PGOHUM00000234361 PGOHUM00000234723
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Genomic Variants
for IGFL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IGFL1 (46733009 - 46734500 bp)
Structural Variations
Database of Genomic Variants (DGV) 6 variations for IGFL1: About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing IGFL1 |
|
Disorders
/ Diseases
for IGFL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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OMIM gene information: 610544
OMIM disorders: --
IGFL1 for disorders About GeneDecksing
Export disorders for IGFL1 gene to outside databases
|
Publications
for IGFL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for IGFL1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with IGFL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
- Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PubMed id 21454693)1, 2 Lobito A.A.... Gonzalez L.C. (J. Biol. Chem. 2011)
- IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PubMed id 16890402)1, 2 Emtage P.... Tang Y.T. (Genomics 2006)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
- The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children. (PubMed id 19147602)1 Ester W.A....Hokken-Koelega A.C. (Eur. J. Endocrinol. 2009)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
- Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch. (PubMed id 8884603)9 Yang S....Goldspink G. (J. Muscle Res. Cell. Motil. 1996)
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External Searches for IGFL1 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing IGFL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
Other Databases showing IGFL1 gene
(According to HUGE)
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Specialized Databases showing IGFL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for IGFL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for IGFL1 gene:
Search GeneIP for patents involving IGFL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IGFL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
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 | |
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| | | | |
 |
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|  | Block miRNA regulation of human, mouse, rat IGFL1 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing IGFL1 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFL1 | | Predesigned siRNA for gene silencing in human, mouse, rat IGFL1 | | | QuantiFast Probe-based Assays in human, mouse, rat IGFL1 | | QuantiTect SYBR Green Assays in human, mouse, rat IGFL1 | | | Custom PCR Arrays for IGFL1 | | Search Chromatin IP Primers for IGFL1 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IGFL1 | | Search GeneGlobe Interaction Network for IGFL1 | | | Regulatory tfbs in IGFL1 promoter |
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 |  |  |  | |
| | | Search Tocris compounds for IGFL1 |
| | |  |  |  |
 | | | | |
 |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL1 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for IGFL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFL1 |
| | | | LSBio Antibodies in human, mouse, rat for IGFL1 |
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