IGFL1 Gene

Aliases
for IGFL1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC19P051425 GC19P043160

Summaries
for IGFL1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for IGFL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000019.9  NC_018930.2  NT_011109.17  

SwitchGear Promoter luciferase reporter plasmid: IGFL1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFL1

IGFL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046733:  view genomic region     (about GC identifiers)

Proteins
for IGFL1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for IGFL1: NX_Q6UW32

Explore proteomics data for IGFL1 at MOPED

Post-translational modifications: 

IGFL1 Human Recombinant Protein Products:

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	antibodies-online peptides for IGFL1

IGFL1 Antibody Products:

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	antibodies-online antibodies for IGFL1 (14 products)

IGFL1 Assay Products:

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	Cloud-Clone Corp. ELISAs for IGFL1 Cloud-Clone Corp. CLIAs for IGFL1
	Search eBioscience for ELISAs for IGFL1
	antibodies-online kits for IGFL1 (2 products)

Domains /
Families
for IGFL1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q6UW32

Function
for IGFL1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for IGFL1

miRNA Products:		Block miRNA regulation of human, mouse, rat IGFL1 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate IGFL1
		SwitchGear 3'UTR luciferase reporter plasmid: IGFL1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for IGFL1
		Predesigned siRNA for gene silencing in human, mouse, rat IGFL1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for IGFL1

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		GenScript: all cDNA clones in your preferred vector: IGFL1 (NM_198541)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGFL1
		Browse ESI BIO Cell Lines and PureStem Progenitors for IGFL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL1

Localization
for IGFL1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
cytosol	1
nucleus	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for IGFL1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for IGFL1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for IGFL1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for IGFL1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IGFL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for IGFL1 OriGene qSTAR qPCR primer pairs in human, mouse for IGFL1
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IGFL1
		QuantiTect SYBR Green Assays in human, mouse, rat IGFL1
		QuantiFast Probe-based Assays in human, mouse, rat IGFL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL1

Orthologs
for IGFL1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for IGFL1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for IGFL1 gene

IGFL2²  IGFL3²  IGFL4²  

3 SIMAP similar genes for IGFL1 using alignment to 1 protein entry:     IGFL1_HUMAN:

IGFL3    IGFL4    IGFL2

Find genes that share paralogs with IGFL1           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for IGFL1
PGOHUM00000234361 PGOHUM00000234723

Genomic Variants
for IGFL1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IGFL1 (see all 122)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs744106171,2	C	--	46731046(+)	CACCAC/TTTGGC	1	--	us2k1		0	--	--	--	--
rs1471097621,2		--	46731077(+)	AGATAC/TCTAGT	1	--	us2k1		0	--	--	--	--
rs1386838701,2		--	46731121(+)	TCATAC/TGATAG	1	--	us2k1		0	--	--	--	--
rs1853930271,2		--	46731139(+)	TAATAA/CTATTC	1	--	us2k1		0	--	--	--	--
rs1889202601,2		--	46731153(+)	CATTAC/TTTGGA	1	--	us2k1		0	--	--	--	--
rs1488227321,2		--	46731291(+)	AAATAC/TGGTAA	1	--	us2k1		0	--	--	--	--
rs1435192211,2		--	46731316(+)	GGAGAA/GTACAC	1	--	us2k1		0	--	--	--	--
rs124595531,2	C,F,A,H	--	46731463(+)	ACAAGG/ACTTCA	1	--	us2k1		3		NA	124
rs72500011,2	C	--	46731484(+)	ataaaA/TaaTTT	1	--	us2k1 tfbs3		0	--	--	--	--
rs1417463811,2		--	46731503(+)	GTGTCA/TTAAAC	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for IGFL1 (46733009 - 46734500 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for IGFL1:    About this table    

Variant ID	Type	Subtype	PubMed ID
dgv3960n71	CNV	Gain	21882294
nsv458714	CNV	Gain	19166990
nsv470147	CNV	Gain	18288195
nsv912179	CNV	Gain	21882294
nsv458713	CNV	Gain	19166990
nsv912180	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing IGFL1

DNA2.0 Custom Variant and Variant Library Synthesis for IGFL1

Disorders / Diseases
for IGFL1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for IGFL1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (Genome Res. 2003)
2. Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PubMed id 21454693)^{1, 2} Lobito A.A.... Gonzalez L.C. (J. Biol. Chem. 2011)
3. IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PubMed id 16890402)^{1, 2} Emtage P.... Tang Y.T. (Genomics 2006)
4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (Protein Sci. 2004)
5. The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children. (PubMed id 19147602)¹ Ester W.A....Hokken-Koelega A.C. (Eur. J. Endocrinol. 2009)
6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (Nature 2004)
7. Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch. (PubMed id 8884603)⁹ Yang S....Goldspink G. (J. Muscle Res. Cell. Motil. 1996)

External Searches for IGFL1 gene

Genome Databases showing IGFL1 gene

Other Databases showing IGFL1 gene

Specialized Databases showing IGFL1 gene

Products
for IGFL1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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