IGFL1 Gene
protein-coding GIFtS: 39
GCID: GC19P046733
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IGF-like family member 1
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Aliases
for IGFL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IGF-Like Family Member 11 2 | | UNQ6441 2 | | APRG6442 | | Insulin Growth Factor-Like Family Member 12 |
Export aliases for IGFL1 gene to outside databasesPrevious GC identifers: GC19P051425 GC19P043160 |
Summaries
for IGFL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IGFL1:
IGFL1 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play criticalroles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006(PubMed 16890402)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32Function: Probable ligand of the IGFLR1 cell membrane receptor
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Genomic Views
for IGFL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IGFL1 gene promoter:
HTF NRSF form 1 LUN-1 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for IGFL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32IGFL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P046733: view genomic region
(about GC identifiers)
Start:
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46,733,009 bp from pter |
End:
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46,734,500 bp from pter |
Size:
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1,492 bases |
Orientation:
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plus strand |
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Proteins
for IGFL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32 (See
protein sequence)Recommended Name: Insulin growth factor-like family member 1 precursor Size: 110 amino acids; 12363 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: SecretedExplore the universe of human proteins at neXtProt for IGFL1: NX_Q6UW32
IGFL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940943.1
ENSEMBL proteins: ENSP00000415823
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IDA | -- |
IGFL1 for ontologies About GeneDecksing
IGFL1 Antibody Products:
Assay Products for IGFL1: |
Protein
Domains /
Families
for IGFL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6UW32 UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32Similarity: Belongs to the IGFL family |
Function
for IGFL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32Function: Probable ligand of the IGFLR1 cell membrane receptor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFL1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGFL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IGFL1 (NM_198541) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGFL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
IGFL1 for ontologies About GeneDecksing
|
Pathways & Interactions
for IGFL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGFL1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for IGFL1 (Q6UW321 ENSP000004158234) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for IGFL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IGFL1
Search CenterWatch for drugs/clinical trials and news about IGFL1
|
Transcripts
for IGFL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IGFL1 gene: NM_198541.1 Unigene Cluster for IGFL1: IGF-like family member 1 Hs.546554 [show with all ESTs]Unigene Representative Sequence: BG7756681 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000437936(uc002pee.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFL1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGFL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IGFL1 (NM_198541) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGFL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFL1 |
Additional cDNA sequence: AY359013.1 AY672111.1 2 DOTS entries: DT.100049000 DT.405917 18 AceView cDNA sequences: BU543034 AY359013 AA455904 AY672111 BF911380 NM_198541 AA456370 CA433564 BG775059 BG775668 AA195677 AW265432 AW991605 BF913866 AW265494 BF914311 BG680336 BF911379
GeneLoc Exon Structure
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Expression
for IGFL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IGFL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IGFL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGFL1
SOURCE GeneReport for Unigene cluster: Hs.546554
UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32Tissue specificity: Detected in ovary and spinal cord
SABiosciences Custom PCR Arrays for IGFL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGFL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IGFL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL1 |
Orthologs
for IGFL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for IGFL1 (if available)
TreeFam Gene Tree for IGFL1 (if available) |
Paralogs
for IGFL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IGFL1 gene
- IGFL22 IGFL42 IGFL32
3 SIMAP similar genes for IGFL1 using alignment to 1 protein entry: IGFL1_HUMAN:IGFL3 IGFL4 IGFL2
IGFL1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for IGFL1
PGOHUM00000234361 PGOHUM00000234723
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Genomic Variants
for IGFL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IGFL1 (46733009 - 46734500 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IGFL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFL1 |
|
Disorders
/ Diseases
for IGFL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IGFL1 for disorders About GeneDecksing
OMIM gene information: 610544
OMIM disorders: --
1  disease for IGFL1: About MalaCardsskin conditions
Export disorders for IGFL1 gene to outside databases
|
Publications
for IGFL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IGFL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGFL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PubMed id 21454693)1, 2 Lobito A.A.... Gonzalez L.C. (2011)
- IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PubMed id 16890402)1, 2 Emtage P....Tang Y.T. (2006)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children. (PubMed id 19147602)1 Ester W.A....Hokken-Koelega A.C. (2009)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch. (PubMed id 8884603)9 Yang S....Goldspink G. (1996)
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External Searches for IGFL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing IGFL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IGFL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IGFL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IGFL1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for IGFL1 gene:
Search GeneIP for patents involving IGFL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IGFL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IGFL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGFL1 | | | OriGene Protein Over-expression Lysate for IGFL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IGFL1 | | OriGene 3'-UTR Clone for IGFL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGFL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IGFL1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IGFL1 | | OriGene Custom Protein Services for IGFL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGFL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFL1 |
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| | | | Search Tocris compounds for IGFL1 |
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 | | | IGFL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for IGFL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFL1 |
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