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IGFL1 Gene

protein-coding   GIFtS: 40
GCID: GC19P046733

IGF-Like Family Member 1

  See IGFL1-related disease
at
MalaCards
 

Aliases
for IGFL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IGF-Like Family Member 11 2
APRG6442
UNQ6442
Insulin Growth Factor-Like Family Member 12

External Ids:    HGNC: 240931   Entrez Gene: 3749182   Ensembl: ENSG000001882937   OMIM: 6105445   UniProtKB: Q6UW323   

Export aliases for IGFL1 gene to outside databases

Previous GC identifers: GC19P051425 GC19P043160


Summaries
for IGFL1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGFL1 Gene:
IGFL1 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play
critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et
al., 2006 (PubMed 16890402)).(supplied by OMIM, Mar 2008)

GeneCards Summary for IGFL1 Gene:
IGFL1 (IGF-like family member 1) is a protein-coding gene. Diseases associated with IGFL1 include skin conditions. An important paralog of this gene is IGFL2.

UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32
Function: Probable ligand of the IGFLR1 cell membrane receptor




Genomic Views
for IGFL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGFL1 gene promoter:
         HTF   NRSF form 1   LUN-1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGFL1 promoter sequence
   Search Chromatin IP Primers for IGFL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

IGFL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFL1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046733:  view genomic region     (about GC identifiers)

Start:
 46,733,009 bp from pter      End:
 46,734,500 bp from pter
Size:
 1,492 bases      Orientation:
 plus strand

Proteins
for IGFL1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32 (See protein sequence)
Recommended Name: Insulin growth factor-like family member 1 precursor  
Size: 110 amino acids; 12363 Da
Subunit: Homodimer; disulfide-linked

Explore the universe of human proteins at neXtProt for IGFL1: NX_Q6UW32

Explore proteomics data for IGFL1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71

    • See IGFL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940943.1  
    ENSEMBL proteins: 
     ENSP00000415823  

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    Domains /
    Families
    for IGFL1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q6UW32

    UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32
    Similarity: Belongs to the IGFL family


    Function
    for IGFL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IGFL1_HUMAN, Q6UW32
    Function: Probable ligand of the IGFLR1 cell membrane receptor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with IGFL1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IGFL1

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    Localization
    for IGFL1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGFL1_HUMAN, Q6UW32: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--

    Find genes that share ontologies with IGFL1           About GenesLikeMe


    Pathways & Interactions
    for IGFL1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Interactions:

        Search GeneGlobe Interaction Network for IGFL1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for IGFL1 (Q6UW321 ENSP000004158234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGFLR1Q9H6651, ENSP000002465324EBI-3870426,EBI-3870439 STRING: ENSP00000246532
    About this table

    Drugs & Compounds
    for IGFL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for IGFL1



    Transcripts
    for IGFL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IGFL1 gene: 
    NM_198541.1  

    Unigene Cluster for IGFL1:

    IGF-like family member 1
    Hs.546554  [show with all ESTs]
    Unigene Representative Sequence: BG775668
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000437936(uc002pee.3)
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    Additional mRNA sequence: 

    AY359013.1 AY672111.1 

    2 DOTS entries:

    DT.100049000  DT.405917 

    18 AceView cDNA sequences:

    BU543034 BG775059 AA455904 CA433564 AY672111 AA456370 AY359013 BG775668 
    NM_198541 BF911380 AA195677 AW265432 AW991605 AW265494 BF913866 BF914311 
    BG680336 BF911379 

    GeneLoc Exon Structure


    Expression
    for IGFL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGFL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGFL1 Expression
    About this image

    IGFL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    IGFL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546554

    UniProtKB/Swiss-Prot: IGFL1_HUMAN, Q6UW32
    Tissue specificity: Detected in ovary and spinal cord

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    Orthologs
    for IGFL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for IGFL1 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    cow
    (Bos taurus)    		 Mammalia LOC5127881 IGF-like family member 1-like 77.67(n)
    67.92(a)    		   512788  XM_002695176.3  XP_002695222.1 


    ENSEMBL Gene Tree for IGFL1 (if available)
    TreeFam Gene Tree for IGFL1 (if available)

    Paralogs
    for IGFL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGFL1 gene
    IGFL22  IGFL32  IGFL42  
    3 SIMAP similar genes for IGFL1 using alignment to 1 protein entry:     IGFL1_HUMAN:
    IGFL3    IGFL4    IGFL2

    Find genes that share paralogs with IGFL1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for IGFL1
    PGOHUM00000234361 PGOHUM00000234723


    Genomic Variants
    for IGFL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGFL1 (see all 122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs744106171,2
    		C--46731046(+) CACCAC/TTTGGC 1 -- us2k10--------
    rs1471097621,2
    		--46731077(+) AGATAC/TCTAGT 1 -- us2k10--------
    rs1386838701,2
    		--46731121(+) TCATAC/TGATAG 1 -- us2k10--------
    rs1853930271,2
    		--46731139(+) TAATAA/CTATTC 1 -- us2k10--------
    rs1889202601,2
    		--46731153(+) CATTAC/TTTGGA 1 -- us2k10--------
    rs1488227321,2
    		--46731291(+) AAATAC/TGGTAA 1 -- us2k10--------
    rs1435192211,2
    		--46731316(+) GGAGAA/GTACAC 1 -- us2k10--------
    rs124595531,2
    		C,F,A,H--46731463(+) ACAAGG/ACTTCA 1 -- us2k13Minor allele frequency- A:0.21NA 124
    rs72500011,2
    		C--46731484(+) ataaaA/TaaTTT 1 -- us2k1 tfbs30--------
    rs1417463811,2
    		--46731503(+) GTGTCA/TTAAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IGFL1 (46733009 - 46734500 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IGFL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3960n71CNV Gain21882294
    nsv458714CNV Gain19166990
    nsv470147CNV Gain18288195
    nsv912179CNV Gain21882294
    nsv458713CNV Gain19166990
    nsv912180CNV Gain21882294

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    Disorders / Diseases
    for IGFL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 610544    OMIM disorders: --

    1 disease for IGFL1:    
    About MalaCards
    skin conditions


    Find genes that share disorders with IGFL1           About GenesLikeMe


    Export disorders for IGFL1 gene to outside databases

    Publications
    for IGFL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGFL1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IGFL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PubMed id 21454693)1, 2 Lobito A.A.... Gonzalez L.C. (J. Biol. Chem. 2011)
    3. IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PubMed id 16890402)1, 2 Emtage P.... Tang Y.T. (Genomics 2006)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    5. The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children. (PubMed id 19147602)1 Ester W.A....Hokken-Koelega A.C. (Eur. J. Endocrinol. 2009)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch. (PubMed id 8884603)9 Yang S....Goldspink G. (J. Muscle Res. Cell. Motil. 1996)

    External Searches for IGFL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IGFL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 374918 HGNC: 24093 AceView: IGFL1 Ensembl:ENSG00000188293 euGenes: HUgn374918
    ECgene: IGFL1 H-InvDB: IGFL1

    Other Databases showing IGFL1 gene

    (According to HUGE)
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    TryGeneCards Plus    		   --

    Specialized Databases showing IGFL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IGFL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IGFL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for IGFL1 gene:
    Search GeneIP for patents involving IGFL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from genOway)
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