Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGFL1 Gene

Aliases for IGFL1 Gene

  • IGF-Like Family Member 1 2 3
  • APRG644 3
  • UNQ644 3

External Ids for IGFL1 Gene

Previous GeneCards Identifiers for IGFL1 Gene

  • GC19P051425
  • GC19P046733
  • GC19P043160

Summaries for IGFL1 Gene

Entrez Gene Summary for IGFL1 Gene

  • IGFL1 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IGFL1 Gene

IGFL1 (IGF-Like Family Member 1) is a Protein Coding gene. Diseases associated with IGFL1 include skin conditions. An important paralog of this gene is IGFL2.

UniProtKB/Swiss-Prot for IGFL1 Gene

  • Probable ligand of the IGFLR1 cell membrane receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFL1 Gene

Genomics for IGFL1 Gene

Regulatory Elements for IGFL1 Gene

Genomic Location for IGFL1 Gene

46,229,752 bp from pter
46,231,243 bp from pter
1,492 bases
Plus strand

Genomic View for IGFL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFL1 Gene

Proteins for IGFL1 Gene

  • Protein details for IGFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin growth factor-like family member 1
    Protein Accession:

    Protein attributes for IGFL1 Gene

    110 amino acids
    Molecular mass:
    12363 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for IGFL1 Gene

Proteomics data for IGFL1 Gene at MOPED

Post-translational modifications for IGFL1 Gene

Other Protein References for IGFL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFL1 Gene

Domains & Families for IGFL1 Gene

Protein Domains for IGFL1 Gene


Suggested Antigen Peptide Sequences for IGFL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IGFL family.
  • Belongs to the IGFL family.
genes like me logo Genes that share domains with IGFL1: view

No data available for Gene Families for IGFL1 Gene

Function for IGFL1 Gene

Molecular function for IGFL1 Gene

UniProtKB/Swiss-Prot Function:
Probable ligand of the IGFLR1 cell membrane receptor.

Gene Ontology (GO) - Molecular Function for IGFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21454693
genes like me logo Genes that share ontologies with IGFL1: view

Phenotypes for IGFL1 Gene

GenomeRNAi human phenotypes for IGFL1:
genes like me logo Genes that share phenotypes with IGFL1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFL1 Gene

Localization for IGFL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFL1 Gene


Subcellular locations from

Jensen Localization Image for IGFL1 Gene COMPARTMENTS Subcellular localization image for IGFL1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IGFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 21454693
genes like me logo Genes that share ontologies with IGFL1: view

Pathways & Interactions for IGFL1 Gene

SuperPathways for IGFL1 Gene

No Data Available

Interacting Proteins for IGFL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q6UW32-IGFL1_HUMAN ENSP00000415823 for IGFL1 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for IGFL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGFL1 Gene

Drugs & Compounds for IGFL1 Gene

No Compound Related Data Available

Transcripts for IGFL1 Gene

mRNA/cDNA for IGFL1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFL1 Gene

IGF-like family member 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFL1 Gene

No ASD Table

Relevant External Links for IGFL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGFL1 Gene

mRNA expression in normal human tissues for IGFL1 Gene

mRNA differential expression in normal tissues according to GTEx for IGFL1 Gene

This gene is overexpressed in Esophagus - Mucosa (x38.3) and Minor Salivary Gland (x5.5).

SOURCE GeneReport for Unigene cluster for IGFL1 Gene Hs.546554

mRNA Expression by UniProt/SwissProt for IGFL1 Gene

Tissue specificity: Detected in ovary and spinal cord.
genes like me logo Genes that share expression patterns with IGFL1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IGFL1 Gene

Orthologs for IGFL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGFL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC512788 35
  • 77.67 (n)
  • 67.92 (a)
IGFL1 36
  • 50 (a)
(Pan troglodytes)
Mammalia IGFL1 35
  • 98.48 (n)
  • 97.27 (a)
IGFL1 36
  • 97 (a)
Species with no ortholog for IGFL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFL1 Gene

Gene Tree for IGFL1 (if available)
Gene Tree for IGFL1 (if available)

Paralogs for IGFL1 Gene

Paralogs for IGFL1 Gene

(3) SIMAP similar genes for IGFL1 Gene using alignment to 1 proteins: Pseudogenes for IGFL1 Gene

genes like me logo Genes that share paralogs with IGFL1: view

Variants for IGFL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGFL1 Gene

Variant ID Type Subtype PubMed ID
nsv912179 CNV Gain 21882294
nsv470147 CNV Gain 18288195
nsv458713 CNV Gain 19166990
nsv458714 CNV Gain 19166990
nsv912180 CNV Gain 21882294
dgv3960n71 CNV Gain 21882294

Variation tolerance for IGFL1 Gene

Residual Variation Intolerance Score: 90.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for IGFL1 Gene

Disorders for IGFL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGFL1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
skin conditions
  • dermatologic disorders
- elite association
Search IGFL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGFL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGFL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFL1 Gene

Publications for IGFL1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 67
  2. Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch. (PMID: 8884603) Yang S. … Goldspink G. (J. Muscle Res. Cell. Motil. 1996) 23 67
  3. Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PMID: 21454693) Lobito A.A. … Gonzalez L.C. (J. Biol. Chem. 2011) 67
  4. The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children. (PMID: 19147602) Ester W.A. … Hokken-Koelega A.C. (Eur. J. Endocrinol. 2009) 67
  5. IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PMID: 16890402) Emtage P. … Tang Y.T. (Genomics 2006) 67

Products for IGFL1 Gene

Sources for IGFL1 Gene

Back to Top