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IGFL1 Gene(Protein Coding)

IGF Like Family Member 1

GCID:
GC19P046229
GIFtS:
44
Genes Participants
UDN Logo

Aliases for IGFL1 Gene

Aliases for IGFL1 Gene

  • IGF Like Family Member 1 2 3 5
  • Insulin Growth Factor-Like Family Member 1 3
  • APRG644 3
  • UNQ644 3

External Ids for IGFL1 Gene

Previous GeneCards Identifiers for IGFL1 Gene

  • GC19P051425
  • GC19P046733
  • GC19P043160

Summaries for IGFL1 Gene

Entrez Gene Summary for IGFL1 Gene

  • The protein encoded by this gene is a member of the insulin-like growth factor family of signaling molecules. The encoded protein is synthesized as a precursor protein and is proteolytically cleaved to form a secreted mature peptide. The mature peptide binds to a receptor, which in mouse was found on the cell surface of T cells. Increased expression of this gene may be linked to psoriasis. [provided by RefSeq, Aug 2016]

GeneCards Summary for IGFL1 Gene

IGFL1 (IGF Like Family Member 1) is a Protein Coding gene. Diseases associated with IGFL1 include Skin Conditions. An important paralog of this gene is IGFL3.

UniProtKB/Swiss-Prot for IGFL1 Gene

  • Probable ligand of the IGFLR1 cell membrane receptor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFL1 Gene

Genomics for IGFL1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for IGFL1 Gene

Enhancers for IGFL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G046192 1.6 Ensembl ENCODE dbSUPER 11.6 -36.8 -36763 2.0 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZC3H4 FBXO46 CCDC61 ENSG00000269148 IGFL1 ENSG00000268810 HIF3A LOC93429 IGFL1P1 LOC105372424
GH19G046200 1.5 Ensembl ENCODE dbSUPER 12.1 -27.1 -27102 4.0 PKNOX1 ATF1 ARNT AGO1 YY1 TCF12 ZNF121 ZNF766 ELK1 ZNF143 LOC93429 IRF2BP1 IGFL1 IGFL2 HIF3A IGFL2-AS1 IGFL1P1
GH19G046205 1 ENCODE dbSUPER 12.2 -23.4 -23438 1.9 KLF1 NFRKB TEAD4 MAX ZFHX2 ZNF766 KDM5B EGR2 ZNF680 MAZ LOC93429 IGFL1 IGFL2-AS1 RPL12P41
GH19G046198 0.7 ENCODE dbSUPER 12 -30.7 -30676 1.8 NR4A1 MLLT1 LOC93429 IGFL1 IGFL2-AS1 IGFL1P1
GH19G046189 0.7 ENCODE 11.6 -40.1 -40124 0.1 CTCF ZNF654 NFIB ZFP64 TRIM22 ZNF2 RAD21 RFX5 YY1 ZNF83 IGFL1 HIF3A LOC105372424 IGFL1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGFL1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IGFL1 gene promoter:

Genomic Location for IGFL1 Gene

Chromosome:
19
Start:
46,229,752 bp from pter
End:
46,231,243 bp from pter
Size:
1,492 bases
Orientation:
Plus strand

Genomic View for IGFL1 Gene

Genes around IGFL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFL1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IGFL1 Gene

Proteins for IGFL1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IGFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW32-IGFL1_HUMAN
    Recommended name:
    Insulin growth factor-like family member 1
    Protein Accession:
    Q6UW32

    Protein attributes for IGFL1 Gene

    Size:
    110 amino acids
    Molecular mass:
    12363 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for IGFL1 Gene

Post-translational modifications for IGFL1 Gene

Other Protein References for IGFL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFL1 Gene

Domains & Families for IGFL1 Gene

Protein Domains for IGFL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGFL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UW32

UniProtKB/Swiss-Prot:

IGFL1_HUMAN :
  • Belongs to the IGFL family.
Family:
  • Belongs to the IGFL family.
genes like me logo Genes that share domains with IGFL1: view

No data available for Gene Families for IGFL1 Gene

Function for IGFL1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IGFL1 Gene

UniProtKB/Swiss-Prot Function:
Probable ligand of the IGFLR1 cell membrane receptor.

Gene Ontology (GO) - Molecular Function for IGFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21454693
genes like me logo Genes that share ontologies with IGFL1: view
genes like me logo Genes that share phenotypes with IGFL1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFL1 Gene

Localization for IGFL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFL1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IGFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 21454693
genes like me logo Genes that share ontologies with IGFL1: view

Pathways & Interactions for IGFL1 Gene

SuperPathways for IGFL1 Gene

PathCards logo More details on SuperPathways for IGFL1
No Data Available

Interacting Proteins for IGFL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000415823%0d%0a9606.ENSP00000246532%0d%0a
Selected Interacting proteins: Q6UW32-IGFL1_HUMAN ENSP00000415823 for IGFL1 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for IGFL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGFL1 Gene

Drugs & Compounds for IGFL1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IGFL1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IGFL1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFL1 Gene

IGF-like family member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFL1 Gene

No ASD Table

Relevant External Links for IGFL1 Gene

GeneLoc Exon Structure for
IGFL1
ECgene alternative splicing isoforms for
IGFL1

Expression for IGFL1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFL1 Gene

mRNA expression in normal human tissues for IGFL1 Gene
mRNA expression by GTEx for IGFL1 Gene

mRNA differential expression in normal tissues according to GTEx for IGFL1 Gene

This gene is overexpressed in Esophagus - Mucosa (x38.3) and Minor Salivary Gland (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of IGFL1 Gene:

IGFL1

SOURCE GeneReport for Unigene cluster for IGFL1 Gene:

Hs.546554

mRNA Expression by UniProt/SwissProt for IGFL1 Gene:

Q6UW32-IGFL1_HUMAN
Tissue specificity: Detected in ovary and spinal cord.
genes like me logo Genes that share expression patterns with IGFL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFL1 Gene

Orthologs for IGFL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGFL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IGFL1 34 35
  • 98.48 (n)
cow
(Bos Taurus)
 Mammalia LOC512788 34
  • 77.67 (n)
IGFL1 35
  • 50 (a)
 OneToOne
Species where no ortholog for IGFL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFL1 Gene

ENSEMBL:
Gene Tree for IGFL1 (if available)
TreeFam:
Gene Tree for IGFL1 (if available)

Paralogs for IGFL1 Gene

Paralogs for IGFL1 Gene

(3) SIMAP similar genes for IGFL1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IGFL1 Gene

genes like me logo Genes that share paralogs with IGFL1: view

Variants for IGFL1 Gene

Sequence variations from dbSNP and Humsavar for IGFL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000169803 -- 46,228,000(+) TCACT(C/T)GCGGT upstream-variant-2KB
rs1000469608 -- 46,228,380(+) GTGTC(C/T)TAGAA upstream-variant-2KB
rs1001080583 -- 46,229,455(+) GTGAG(A/T)GTCGG upstream-variant-2KB
rs1001407664 -- 46,229,189(+) GAGTG(-/T)TGAGT upstream-variant-2KB
rs1003644862 -- 46,231,202(+) GGAGC(A/G)AAGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IGFL1 Gene

Variant ID Type Subtype PubMed ID
dgv147n111 CNV duplication 26073780
dgv3607n100 CNV gain 25217958
dgv665e214 CNV gain 21293372
esv2762042 CNV loss 21179565
esv3644523 CNV gain 21293372
esv3893222 CNV gain 25118596
nsv458713 CNV gain 19166990
nsv458714 CNV gain 19166990
nsv470147 CNV gain 18288195
nsv579886 CNV gain 21841781
nsv579887 CNV gain 21841781

Variation tolerance for IGFL1 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFL1 Gene

Disorders for IGFL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGFL1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
skin conditions
  • dermatologic disorders
- elite association - COSMIC cancer census association via MalaCards
Search IGFL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGFL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFL1
genes like me logo Genes that share disorders with IGFL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFL1 Gene

Publications for IGFL1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (PMID: 21454693) Lobito A.A. … Gonzalez L.C. (J. Biol. Chem. 2011) 3 4 64
  3. IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PMID: 16890402) Emtage P. … Tang Y.T. (Genomics 2006) 3 4 64
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  5. The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children. (PMID: 19147602) Ester W.A. … Hokken-Koelega A.C. (Eur. J. Endocrinol. 2009) 3 64

Products for IGFL1 Gene

Sources for IGFL1 Gene

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