Aliases for IGFL1 Gene
Aliases for IGFL1 Gene
External Ids for IGFL1 Gene
- HGNC: 24093
- Entrez Gene: 374918
- Ensembl: ENSG00000188293
- OMIM: 610544
- UniProtKB: Q6UW32
Previous GeneCards Identifiers for IGFL1 Gene
- GC19P051425
- GC19P046733
- GC19P043160
Summaries for IGFL1 Gene
-
The protein encoded by this gene is a member of the insulin-like growth factor family of signaling molecules. The encoded protein is synthesized as a precursor protein and is proteolytically cleaved to form a secreted mature peptide. The mature peptide binds to a receptor, which in mouse was found on the cell surface of T cells. Increased expression of this gene may be linked to psoriasis. [provided by RefSeq, Aug 2016]
GeneCards Summary for IGFL1 Gene
IGFL1 (IGF Like Family Member 1) is a Protein Coding gene. Diseases associated with IGFL1 include Skin Conditions. An important paralog of this gene is IGFL3.
UniProtKB/Swiss-Prot for IGFL1 Gene
-
Probable ligand of the IGFLR1 cell membrane receptor.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFL1 Gene
Genomics for IGFL1 Gene
GeneHancer (GH) Regulatory Elements for IGFL1 Gene
Promoters and enhancers for IGFL1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19I046229 | Promoter | 0.7 | EPDnew | 550.8 | 0.0 | -28 | 0.1 | ATF2 ZBTB17 | ENSG00000269745 IGFL1 IGFL2-AS1 PIR58292 | |
| GH19I046192 | Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 11.6 | -36.8 | -36762 | 2 | PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 | ZC3H4 IGFL1 ENSG00000268810 HIF3A ERCC1 QPCTL LOC93429 IGFL1P1 LOC105372424 IGFL2-AS1 | |
| GH19I046200 | Enhancer | 1.3 | Ensembl ENCODE dbSUPER | 12.1 | -27.1 | -27101 | 4 | PKNOX1 ATF1 ARNT TCF12 ZNF766 ATF7 FOS CAVIN1 NCOA1 SMARCB1 | LOC93429 IGFL1 IGFL2 HIF3A IGFL2-AS1 IGFL1P1 | |
| GH19I046205 | Enhancer | 0.9 | ENCODE dbSUPER | 12.2 | -23.4 | -23437 | 1.9 | MEIS2 KLF1 NFRKB MAX ZFHX2 ZNF766 EGR2 ZNF680 MAZ L3MBTL2 | LOC93429 IGFL1 IGFL2-AS1 RPL12P41 | |
| GH19I046198 | Enhancer | 0.7 | ENCODE dbSUPER | 12 | -30.7 | -30675 | 1.8 | SP1 ATF3 NR4A1 ZBTB33 FOSL2 MLLT1 | LOC93429 IGFL1 IGFL2-AS1 IGFL1P1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around IGFL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IGFL1 gene promoter:
Regulatory Element Products
Genomic Locations for IGFL1 Gene
Genomic Locations for IGFL1 Gene
- chr19:46,229,752-46,231,243
- (GRCh38/hg38)
- Size:
- 1,492 bases
- Orientation:
- Plus strand
- chr19:46,733,009-46,734,500
- (GRCh37/hg19)
Genomic View for IGFL1 Gene
Genes around IGFL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.32 by Ensembl
- 19q13.32 by Entrez Gene
- 19q13.32 by HGNC
IGFL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGFL1 Gene
Proteins for IGFL1 Gene
-
Protein details for IGFL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UW32-IGFL1_HUMAN
- Recommended name:
- Insulin growth factor-like family member 1
- Protein Accession:
- Q6UW32
Protein attributes for IGFL1 Gene
- Size:
- 110 amino acids
- Molecular mass:
- 12363 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked.
Post-translational modifications for IGFL1 Gene
- Glycosylation at posLast=7171
Other Protein References for IGFL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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Protein Products
-
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Assay Products
No data available for DME Specific Peptides for IGFL1 Gene
Domains & Families for IGFL1 Gene
Gene Families for IGFL1 Gene
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for IGFL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6UW32- Family:
-
- Belongs to the IGFL family.
Function for IGFL1 Gene
Molecular function for IGFL1 Gene
- UniProtKB/Swiss-Prot Function:
- Probable ligand of the IGFLR1 cell membrane receptor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21454693 |
Phenotypes for IGFL1 Gene
- GenomeRNAi human phenotypes for IGFL1:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for IGFL1 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for IGFL1
- genomics-online: gRNA clones - Search results for 33 available IGFL1 gene related products
- Overview of 33 available IGFL1 gene related products
- Applied Biological Materials CRISPR for IGFL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFL1
miRNA Products
- Search ViGene Biosciences for IGFL1
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 33 available IGFL1 gene related products
- Overview of 33 available IGFL1 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for IGFL1 gene
Clone Products
- Sino Biological Human cDNA Clone for IGFL1
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGFL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IGFL1
-
ViGene Biosciences adenoviral particle packaged cDNA for IGFL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IGFL1 gene
-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFL1 Gene
Localization for IGFL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGFL1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 21454693 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGFL1 Gene
Pathways & Interactions for IGFL1 Gene
No Data Available
Interacting Proteins for IGFL1 Gene
Selected Interacting proteins:
Q6UW32-IGFL1_HUMAN
ENSP00000415823
for IGFL1 Gene via
IID
UniProtKB
STRING
No data available for Pathways by source and SIGNOR curated interactions for IGFL1 Gene
Transcripts for IGFL1 Gene
mRNA/cDNA for IGFL1 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (18) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IGFL1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IGFL1
- genomics-online: gRNA clones - Search results for 33 available IGFL1 gene related products
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- Applied Biological Materials CRISPR for IGFL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFL1
miRNA Products
- Search ViGene Biosciences for IGFL1
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for IGFL1
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- genomics-online: shRNA clones - Search results for 33 available IGFL1 gene related products
- Overview of 33 available IGFL1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IGFL1 gene
Clone Products
- Sino Biological Human cDNA Clone for IGFL1
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- VectorBuilder custom plasmid, inducible vectors for IGFL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGFL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGFL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for IGFL1 Gene
mRNA differential expression in normal tissues according to GTEx for IGFL1 Gene
This gene is overexpressed in Esophagus - Mucosa (x38.3) and Minor Salivary Gland (x5.5).
NURSA nuclear receptor signaling pathways regulating expression of IGFL1 Gene:
IGFL1SOURCE GeneReport for Unigene cluster for IGFL1 Gene:
Hs.546554mRNA Expression by UniProt/SwissProt for IGFL1 Gene:
Q6UW32-IGFL1_HUMAN
Tissue specificity:
Detected in ovary and spinal cord.
Primer Products
-
OriGene qPCR primer pairs for IGFL1
-
OriGene qPCR primer pairs and template standards for IGFL1
- genomics-online: primer clones - Search results for 33 available IGFL1 gene related products
- Overview of 33 available IGFL1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFL1 Gene
Orthologs for IGFL1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IGFL1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC512788 33 |
|
||
| IGFL1 34 |
|
OneToOne |
- Species where no ortholog for IGFL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for IGFL1 Gene
(3) SIMAP similar genes for IGFL1 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for IGFL1 Gene
Variants for IGFL1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000169803 | -- | 46,228,000(+) | T/C | upstream_transcript_variant | |
| rs1000469608 | -- | 46,228,380(+) | C/T | upstream_transcript_variant | |
| rs1001080583 | -- | 46,229,455(+) | T/A | upstream_transcript_variant | |
| rs1001407664 | -- | 46,229,189(+) | TT/T | upstream_transcript_variant | |
| rs1003644862 | -- | 46,231,202(+) | A/G | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv147n111 | CNV | duplication | 26073780 |
| dgv3607n100 | CNV | gain | 25217958 |
| dgv665e214 | CNV | gain | 21293372 |
| esv2762042 | CNV | loss | 21179565 |
| esv3644523 | CNV | gain | 21293372 |
| esv3893222 | CNV | gain | 25118596 |
| nsv458713 | CNV | gain | 19166990 |
| nsv458714 | CNV | gain | 19166990 |
| nsv470147 | CNV | gain | 18288195 |
| nsv579886 | CNV | gain | 21841781 |
| nsv579887 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.03;
50.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IGFL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IGFL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFL1 Gene
Disorders for IGFL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| skin conditions |
|
|
Search IGFL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IGFL1
No data available for UniProtKB/Swiss-Prot and Genatlas for IGFL1 Gene
Publications for IGFL1 Gene
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
- Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. (PMID: 21454693) Lobito AA … Gonzalez LC (The Journal of biological chemistry 2011) 3 4 58
- IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PMID: 16890402) Emtage P … Tang YT (Genomics 2006) 3 4 58
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
- The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children. (PMID: 19147602) Ester WA … Hokken-Koelega AC (European journal of endocrinology 2009) 3 58
Products for IGFL1 Gene
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- Invitrogen Antibodies for IGFL1
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- VectorBuilder custom plasmid, inducible vectors for IGFL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGFL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available IGFL1 related products ranked by validation data
- antibodies-online: Search results for available IGFL1 related products ranked by validation data
- antibodies-online: Search results for available IGFL1 related products ranked by validation data
- Search GeneTex for Antibodies for IGFL1
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- ViGene Biosciences adenoviral particle packaged cDNA for IGFL1 gene
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- Search ViGene Biosciences for IGFL1
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- genomics-online: cdna clones - Search results for 33 available IGFL1 gene related products
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- Overview of 33 available IGFL1 gene related products
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- Overview of 33 available IGFL1 gene related products
Sources for IGFL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (25) HMDB
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- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
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- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
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- (86) RefSeq
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- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
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- (147) Gene ORGANizer
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- (150) Human Protein Atlas
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- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew