Aliases for IGFBPL1 Gene
Aliases for IGFBPL1 Gene
External Ids for IGFBPL1 Gene
- HGNC: 20081
- Entrez Gene: 347252
- Ensembl: ENSG00000137142
- OMIM: 610413
- UniProtKB: Q8WX77
Previous GeneCards Identifiers for IGFBPL1 Gene
- GC09M038399
Summaries for IGFBPL1 Gene
GeneCards Summary for IGFBPL1 Gene
IGFBPL1 (Insulin Like Growth Factor Binding Protein Like 1) is a Protein Coding gene. Diseases associated with IGFBPL1 include Umbilical Hernia. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is IGFBP7.
UniProtKB/Swiss-Prot for IGFBPL1 Gene
-
IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.
Additional gene information for IGFBPL1 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBPL1 Gene
Genomics for IGFBPL1 Gene
GeneHancer (GH) Regulatory Elements for IGFBPL1 Gene
Promoters and enhancers for IGFBPL1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09I038423 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE | 550.8 | -0.1 | -72 | 1.1 | MXI1 RNF2 HLF NFYC SIN3A ZBTB8A E2F1 POLR2A MXD3 | IGFBPL1 LOC105376041 | |
| GH09I038379 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 10.9 | +37.2 | 37222 | 15.1 | HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 | ALDH1B1 IGFBPL1 SLC25A51 LOC105376040 | |
| GH09I038437 | Enhancer | 1 | Ensembl ENCODE | 17.2 | -13.0 | -13020 | 1.7 | ELF3 FOXA2 ARID4B DMAP1 RAD21 ZNF48 ZSCAN9 ETS1 YY1 CREM | IGFBPL1 ALDH1B1 TCEA1P3 ENSG00000283162 ARMC8P1 | |
| GH09I038420 | Enhancer | 0.7 | ENCODE | 16.7 | +2.6 | 2631 | 1.9 | PKNOX1 RFX1 ZBTB8A BMI1 ZIC2 GATA3 PRDM6 POLR2A ZNF341 RCOR1 | IGFBPL1 PIR62369 | |
| GH09I038434 | Enhancer | 0.7 | ENCODE | 15.1 | -10.2 | -10224 | 2.7 | ELF3 SOX13 CTCF MXI1 SAP130 MAX CEBPG RARA SOX5 ZNF654 | ENSG00000283162 IGFBPL1 ALDH1B1 TCEA1P3 ARMC8P1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around IGFBPL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IGFBPL1 gene promoter:
Regulatory Element Products
Genomic Locations for IGFBPL1 Gene
Genomic Locations for IGFBPL1 Gene
- chr9:38,406,528-38,424,447
- (GRCh38/hg38)
- Size:
- 17,920 bases
- Orientation:
- Minus strand
- chr9:38,408,991-38,424,444
- (GRCh37/hg19)
Genomic View for IGFBPL1 Gene
Genes around IGFBPL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p13.1 by Ensembl
- 9p13.1 by Entrez Gene
- 9p13.1 by HGNC
IGFBPL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGFBPL1 Gene
Proteins for IGFBPL1 Gene
-
Protein details for IGFBPL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WX77-IBPL1_HUMAN
- Recommended name:
- Insulin-like growth factor-binding protein-like 1
- Protein Accession:
- Q8WX77
Protein attributes for IGFBPL1 Gene
- Size:
- 278 amino acids
- Molecular mass:
- 29005 Da
- Quaternary structure:
- No Data Available
Protein Expression for IGFBPL1 Gene
Post-translational modifications for IGFBPL1 Gene
- Glycosylation at posLast=166166 and isoforms=268
Other Protein References for IGFBPL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IGFBPL1 (IGFBP-L1)
-
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-
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Protein Products
-
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Assay Products
No data available for DME Specific Peptides for IGFBPL1 Gene
Domains & Families for IGFBPL1 Gene
Gene Families for IGFBPL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for IGFBPL1 Gene
Suggested Antigen Peptide Sequences for IGFBPL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for IGFBPL1 Gene
Function for IGFBPL1 Gene
Molecular function for IGFBPL1 Gene
- UniProtKB/Swiss-Prot Function:
- IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in multiple tumors.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005520 | insulin-like growth factor binding | IEA | -- |
Phenotypes for IGFBPL1 Gene
- GenomeRNAi human phenotypes for IGFBPL1:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for IGFBPL1 gene
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CRISPR Products
-
OriGene CRISPR knockouts for IGFBPL1
- genomics-online: gRNA clones - Search results for 70 available IGFBPL1 gene related products
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- Applied Biological Materials CRISPR for IGFBPL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBPL1
- GenScript: Design CRISPR guide RNA sequences for IGFBPL1
miRNA for IGFBPL1 Gene
- miRTarBase miRNAs that target IGFBPL1
miRNA Products
- Search ViGene Biosciences for IGFBPL1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFBPL1
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGFBPL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IGFBPL1
-
ViGene Biosciences adenoviral particle packaged cDNA for IGFBPL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IGFBPL1 gene
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFBPL1 Gene
Localization for IGFBPL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGFBPL1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| nucleus | 2 |
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 15845387 |
Pathways & Interactions for IGFBPL1 Gene
No Data Available
Interacting Proteins for IGFBPL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | IEA | -- |
| GO:0071228 | cellular response to tumor cell | IEP | 15845387 |
No data available for Pathways by source and SIGNOR curated interactions for IGFBPL1 Gene
Transcripts for IGFBPL1 Gene
mRNA/cDNA for IGFBPL1 Gene
- (2) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (65) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IGFBPL1 Gene
- Insulin-like growth factor binding protein-like 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for IGFBPL1
- genomics-online: gRNA clones - Search results for 70 available IGFBPL1 gene related products
- Overview of 70 available IGFBPL1 gene related products
- Applied Biological Materials CRISPR for IGFBPL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBPL1
- GenScript: Design CRISPR guide RNA sequences for IGFBPL1
miRNA Products
- Search ViGene Biosciences for IGFBPL1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFBPL1
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- Overview of 70 available IGFBPL1 gene related products
- Search ViGene Biosciences for IGFBPL1
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IGFBPL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGFBPL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGFBPL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: |
Expression for IGFBPL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Choroid Plexus Progenitor Cells Choroid Plexus
- Endothelial Cells Blood Brain Barrier
- Hypothalamus
- Thalamus
- Striatum
- Neural Tube (Nervous System)
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Gut Tube (Gastrointestinal Tract)
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for IGFBPL1 Gene
This gene is overexpressed in Artery - Aorta (x7.0) and Artery - Tibial (x5.4).
This gene is overexpressed in Amniocyte (50.2), Fetal Brain (11.7), and Pancreas (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGFBPL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of IGFBPL1 Gene:
IGFBPL1SOURCE GeneReport for Unigene cluster for IGFBPL1 Gene:
Hs.349705mRNA Expression by UniProt/SwissProt for IGFBPL1 Gene:
Q8WX77-IBPL1_HUMAN
Tissue specificity:
Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung.
Evidence on tissue expression from TISSUES for IGFBPL1 Gene
- Nervous system(2.3)
Primer Products
-
OriGene qPCR primer pairs for IGFBPL1
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No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBPL1 Gene
Orthologs for IGFBPL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IGFBPL1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | IGFBPL1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IGFBPL1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Igfbpl1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Igfbpl1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | IGFBPL1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | IGFBPL1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | IGFBPL1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | igfbpl1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | kazald2 34 |
|
ManyToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for IGFBPL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IGFBPL1 Gene
Variants for IGFBPL1 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000127974 | -- | 38,414,000(-) | T/C | downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000444218 | -- | 38,425,662(-) | C/T | upstream_transcript_variant | |
| rs1000451218 | -- | 38,410,591(-) | T/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000512648 | -- | 38,406,567(-) | C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000632551 | -- | 38,424,323(-) | CCGGCC/C | coding_sequence_variant, frameshift |
Gene Damage Index Score:
3.14;
51.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IGFBPL1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBPL1 Gene
Disorders for IGFBPL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| umbilical hernia |
|
|
Search IGFBPL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IGFBPL1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBPL1 Gene
Publications for IGFBPL1 Gene
- Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties. (PMID: 15845387) Cai Z … Dedera DA (Biochemical and biophysical research communications 2005) 3 4 58
- A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits. (PMID: 22384028) Guo Y … Thomas NG (PloS one 2012) 44 58
- A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang SJ … Fox CS (BMC medical genetics 2007) 44 58
- Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 44 58
- Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes. (PMID: 17634530) Smith P … Crook T (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 3 58
Products for IGFBPL1 Gene
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- Invitrogen Antibodies for IGFBPL1
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGFBPL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for IGFBPL1
- Search GeneTex for Proteins for IGFBPL1
- ViGene Biosciences adenoviral particle packaged cDNA for IGFBPL1 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for IGFBPL1
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Sources for IGFBPL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
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