Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGFBPL1 Gene

protein-coding GIFtS: 46
GCID: GC09M038396

Insulin-Like Growth Factor Binding Protein-Like 1

2 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Insulin-Like Growth Factor Binding Protein-Like 1¹ ²		bA113O24.1²
Insulin-Like Growth Factor-Binding-Related Protein 4² ³		Insulin-Like Growth Factor Binding Protein Related Protein 4²
IGFBPRP4² ³		Insulin-Like Growth Factor-Binding Protein-Like 1²
IGFBP-Related Protein 10² ³		IGFBP-rP4³
IGFBP-RP4²

External Ids:	HGNC: 20081¹	Entrez Gene: 347252²	Ensembl: ENSG00000137142⁷	OMIM: 610413⁵	UniProtKB: Q8WX77³

Export aliases for IGFBPL1 gene to outside databases

Previous GC identifer: GC09M038399

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGFBPL1 Gene:

IGFBPL1 (insulin-like growth factor binding protein-like 1) is a protein-coding gene. Diseases associated with IGFBPL1 include breast cancer, and prostatitis. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is KAZALD1.

UniProtKB/Swiss-Prot: IBPL1_HUMAN, Q8WX77

Function: IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the

growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface

receptors (By similarity). May be a putative tumor suppressor protein

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.2 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGFBPL1 gene promoter:
SRF AhR Egr-2 Nkx6-1 SRF (504 AA) FOXJ2 (long isoform) FOXJ2 Arnt
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGFBPL1 promoter sequence

Search SABiosciences Chromatin IP Primers for IGFBPL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBPL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.1 Ensembl cytogenetic band: 9p13.1 HGNC cytogenetic band: 9p12

IGFBPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBPL1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M038396: view genomic region (about GC identifiers)

Start:	38,408,991 bp from pter	End:	38,424,444 bp from pter
Size:	15,454 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IBPL1_HUMAN, Q8WX77 (See protein sequence)

Recommended Name: Insulin-like growth factor-binding protein-like 1 precursor

Size: 278 amino acids; 29005 Da

Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for IGFBPL1: NX_Q8WX77

Explore proteomics data for IGFBPL1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8WX77

IGFBPL1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001007564.1

ENSEMBL proteins:

ENSP00000366923

Human Recombinant Protein Products for IGFBPL1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for IGFBPL1 OriGene Protein Over-expression Lysate for IGFBPL1 OriGene MassSpec for IGFBPL1 OriGene Custom Protein Services for IGFBPL1
	GenScript Custom Purified and Recombinant Proteins Services for IGFBPL1
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for IGFBPL1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

IGFBPL1 for ontologies About GeneDecksing

IGFBPL1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for IGFBPL1 (IGFBP-L1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for IGFBPL1
	GenScript Custom Superior Antibodies Services for IGFBPL1
	Novus Biologicals IGFBPL1 Antibody
	Abcam antibodies for IGFBPL1
	Cloud-Clone Corp. Antibodies for IGFBPL1
	Search ThermoFisher Antibodies for IGFBPL1
	LSBio Antibodies in human, mouse, rat for IGFBPL1

Assay Products for IGFBPL1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for IGFBPL1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IGFBPL1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for IGFBPL1 Cloud-Clone Corp. CLIAs for IGFBPL1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ISET: Immunoglobulin superfamily / I-set domain containing

5/7 InterPro protein domains (see all 7):

IPR003598 Ig_sub2

IPR002350 Kazal_dom

IPR013098 Ig_I-set

IPR013783 Ig-like_fold

IPR011390 IGFBP_rP_mac25

Graphical View of Domain Structure for InterPro Entry Q8WX77

ProtoNet protein and cluster: Q8WX77

2 Blocks protein domains:

IPB003598 Immunoglobulin C-2 type

IPB013098 Immunoglobulin I-set

UniProtKB/Swiss-Prot: IBPL1_HUMAN, Q8WX77

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 IGFBP N-terminal domain

Similarity: Contains 1 Kazal-like domain

IGFBPL1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IBPL1_HUMAN, Q8WX77

Function: IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the

growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface

receptors (By similarity). May be a putative tumor suppressor protein

Induction: Down-regulated in multiple tumors

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0005520	insulin-like growth factor binding	IEA	--

IGFBPL1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for IGFBPL1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGFBPL1

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBPL1
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBPL1:
		hsa-miR-3163 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-548n hsa-miR-548l
		SwitchGear 3'UTR luciferase reporter plasmid: IGFBPL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for IGFBPL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBPL1
		Sirion Biotech Custom design and validation of potent shRNA sequences against IGFBPL1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IGFBPL1
			Sirion Biotech Customized adenovirus for overexpression of IGFBPL1 Customized adenovirus for potent knockdown of IGFBPL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for IGFBPL1 (see all 7) OriGene ORF clones in mouse, rat for IGFBPL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IGFBPL1 (NM_001007563)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBPL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBPL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGFBPL1
		Search LifeMap BioReagents cell lines for IGFBPL1
		Sirion Biotech Customized stable knockdown cell line services for IGFBPL1 Customized inducible knockdown cell line services for IGFBPL1 Customized stable overexpressing cell line services for IGFBPL1 Customized inducible overexpressing cell line services for IGFBPL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBPL1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IGFBPL1

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--

IGFBPL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGFBPL1 (IBPL1)

Search CenterWatch for drugs/clinical trials and news about IGFBPL1 / IBPL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IGFBPL1 gene:

NM_001007563.2

Unigene Cluster for IGFBPL1:

Insulin-like growth factor binding protein-like 1

Hs.349705 [show with all ESTs]

Unigene Representative Sequence: NM_001007563

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000377694(uc004aba.3)

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBPL1
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBPL1:
		hsa-miR-3163 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-548n hsa-miR-548l
		SwitchGear 3'UTR luciferase reporter plasmid: IGFBPL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for IGFBPL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBPL1
		Sirion Biotech Custom design and validation of potent shRNA sequences against IGFBPL1

Clone Products:		OriGene clones in human, mouse for IGFBPL1 (see all 7) OriGene ORF clones in mouse, rat for IGFBPL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IGFBPL1 (NM_001007563)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBPL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBPL1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IGFBPL1
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IGFBPL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBPL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBPL1

Additional mRNA sequence:

AK055716.1 AK131521.1

2 DOTS entries:

DT.102823294 DT.95153867

24/65 AceView cDNA sequences (see all 65):

BQ899312 BE857533 AW089149 AA598689 AI424991 AI863108 AA676754 CR595424

CR607939 BQ680274 AW088875 AI364268 BM723941 BM701473 BQ681660 AA620528

Z41952 H06382 BM674526 AW016452 BQ877552 AL520498 AA813482 BU956478

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBPL1 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b
SP1:					-		-
SP2:													-
SP3:

ECgene alternative splicing isoforms for IGFBPL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGFBPL1 expression in normal human tissues (normalized intensities) IGFBPL1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATGTCACGAC

About this image

IGFBPL1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/7 selected tissues (see all 7) fully expand


Brain (Nervous System) fully expand to see all 11 entries
Choroid Plexus Progenitor Cells Choroid Plexus
Thalamus
brain/midbrain

Neural Tube (Nervous System) fully expand to see all 3 entries
Metencephalon

Eye (Sensory Organs) fully expand to see all 2 entries
Retina

Pancreas (Endocrine System)
visceral organ/gut/foregut-midgut junction

Gut Tube (Gastrointestinal Tract)
Foregut

See IGFBPL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGFBPL1

SOURCE GeneReport for Unigene cluster: Hs.349705

UniProtKB/Swiss-Prot: IBPL1_HUMAN, Q8WX77

Tissue specificity: Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder

and lung

SABiosciences Custom PCR Arrays for IGFBPL1

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IGFBPL1
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IGFBPL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBPL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBPL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBPL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IGFBPL1 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Igfbpl1^{1 , 5}	insulin-like growth factor binding protein-like 1^{1, 5}	81.47(n)¹ 79.1(a)¹		4 (24.36 cM)⁵ 75426¹ NM_018741.2¹ NP_061211.1¹ 45809468⁵
lizard (Anolis carolinensis)	Reptilia	IGFBPL1⁶	Uncharacterized protein	56(a)	1 ↔ 1	GL343201.1(3959797-4016237)
zebrafish (Danio rerio)	Actinopterygii	kazald2⁶	Kazal-type serine peptidase inhibitor domain 2	26(a)	possible ortholog	14(5811097-5823208)

ENSEMBL Gene Tree for IGFBPL1 (if available)
TreeFam Gene Tree for IGFBPL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGFBPL1 gene

KAZALD1² IGFBP7²

1 SIMAP similar gene for IGFBPL1 using alignment to 1 protein entry: IBPL1_HUMAN:

IGFBP7

IGFBPL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5897733^1,2	C	--	38381470(+)	`TTTCT-/ACACA/CACA/CTCA CACACACACACACACACAcacac`	1	--	int¹ trp³		0	--	--	--	--
rs193061459^1,2		--	38406174(+)	`AACATA/TTGACT`	1	--	ds500¹		0	--	--	--	--
rs10973789^1,2	C,F,A,H	--	38406178(+)	`TATGAC/TTTTCG`	1	--	ds500¹		27		NA NS EA CSA WA	2914
rs10973790^1,2	C,F	--	38406230(+)	`GTGTGA/G/TGAGGG`	1	--	ds500¹		7		NA WA EA	366
rs182982427^1,2		--	38406278(+)	`AATGCA/GTACAC`	1	--	ds500¹		0	--	--	--	--
rs148036411^1,2		--	38406324(+)	`ATGATC/TAGGGC`	1	--	ds500¹		0	--	--	--	--
rs10973791^1,2	C,F,H	--	38406339(+)	`TAAAAA/GTTTCG`	1	--	ds500¹		10		EA NS NA WA CSA	534
rs10814689^1,2	C,F,A,H	--	38406340(+)	`AAAAAT/CTTCGG`	1	--	ds500¹		10		EA NS NA WA CSA	528
rs10758496^1,2	C,F,A,H	--	38406367(+)	`GGCTGT/CGATCG`	1	--	ds500¹		11		NA WA CSA EA	373
rs115227811^1,2	F	--	38406425(+)	`GGGCAT/GGCAGA`	1	--	ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for IGFBPL1 (38408991 - 38424444 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for IGFBPL1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv6537	CNV	Insertion	18451855
esv34172	CNV	Loss	18971310
nsv8445	CNV	Gain+Loss	18304495

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFBPL1

DNA2.0 Custom Variant and Variant Library Synthesis for IGFBPL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGFBPL1 for disorders           About GeneDecksing

OMIM gene information: 610413    OMIM disorders: --

2 diseases for IGFBPL1:    About MalaCards

breast cancer prostatitis

Genetic Association Database (GAD): IGFBPL1

Export disorders for IGFBPL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGFBPL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGFBPL1)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties. (PubMed id 15845387)^{1, 2} Cai Z.... Dedera D.A. (2005)
A genome-wide linkage and association scan reveals nov el loci for hypertension and blood pressure traits. (PubMed id 22384028)⁴ Guo Y....Thomas N.G. (2012)
Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes. (PubMed id 17634530)¹ Smith P....Crook T. (2007)
Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)⁴ Kiel D.P....Karasik D. (2007)
A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)⁴ Hwang S.J....Fox C.S. (2007)
Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells. (PubMed id 17884839)¹ Kutsukake M....Tamura K. (2007)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 347252	HGNC: 20081	AceView: IGFBPL1	Ensembl:ENSG00000137142	euGenes: HUgn347252
ECgene: IGFBPL1	H-InvDB: IGFBPL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IGFBPL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IGFBPL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IGFBPL1 gene:
Search GeneIP for patents involving IGFBPL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for IGFBPL1 (IGFBP-L1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for IGFBPL1
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for IGFBPL1
	OriGene MassSpec something-or-other for IGFBPL1		OriGene clones in human, mouse for IGFBPL1
	OriGene qSTAR qPCR primer pairs in human, mouse for IGFBPL1		OriGene Purified Protein for IGFBPL1
	OriGene ORF clones in mouse, rat for IGFBPL1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for IGFBPL1		OriGene Custom Protein Services for IGFBPL1

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGFBPL1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFBPL1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBPL1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBPL1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBPL1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBPL1

	GenScript Custom Purified and Recombinant Proteins Services for IGFBPL1		GenScript cDNA clones with any tag delivered in your preferred vector for IGFBPL1
	GenScript Custom Assay Services for IGFBPL1		GenScript Custom Superior Antibodies Services for IGFBPL1
	GenScript Custom overexpressing Cell Line Services for IGFBPL1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in IGFBPL1 promoter
	Search Chromatin IP Primers for IGFBPL1
	RT² qPCR Primer Assay in human, mouse, rat IGFBPL1
	Search GNC Networks for IGFBPL1
	SABiosciences Custom PCR Arrays for IGFBPL1

Search Tocris compounds for IGFBPL1 (IBPL1)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	IGFBPL1 antibodies

	Antibodies for IGFBPL1
	See all of Abcam's Antibodies, Kits and Proteins for IGFBPL1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for IGFBPL1
	Antibodies for IGFBPL1
	ELISAs for IGFBPL1
	CLIAs for IGFBPL1

Search LifeMap BioReagents cell lines for IGFBPL1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBPL1

	SwitchGear 3'UTR luciferase reporter plasmids for IGFBPL1
	SwitchGear Promoter luciferase reporter plasmids for IGFBPL1

Search ThermoFisher Antibodies for IGFBPL1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBPL1

	inGenious Targeting Laboratory - Custom generated mouse model solutions for IGFBPL1
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGFBPL1

Customized:

	stable knockdown cell line services for IGFBPL1
	inducible knockdown cell line services for IGFBPL1
	design and validation of potent shRNA sequences against IGFBPL1
	adenovirus for potent knockdown of IGFBPL1
	stable overexpressing cell line services for IGFBPL1
	inducible overexpressing cell line services for IGFBPL1
	adenovirus for overexpression of IGFBPL1

LSBio Antibodies in human, mouse, rat for IGFBPL1

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IGFBPL1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

IGFBPL1 Gene

Insulin-Like Growth Factor Binding Protein-Like 1

Aliases
for IGFBPL1 gene

Summaries
for IGFBPL1 gene

Genomic Views
for IGFBPL1 gene

Proteins
for IGFBPL1 gene

Protein Domains /
Families
for IGFBPL1 gene

Function
for IGFBPL1 gene

Pathways & Interactions
for IGFBPL1 gene

Drugs & Compounds
for IGFBPL1 gene

Transcripts
for IGFBPL1 gene

Expression
for IGFBPL1 gene

Orthologs
for IGFBPL1 gene

Paralogs
for IGFBPL1 gene

Genomic Variants
for IGFBPL1 gene

Disorders / Diseases
for IGFBPL1 gene

Publications
for IGFBPL1 gene

External Searches for IGFBPL1 gene

Genome Databases showing IGFBPL1 gene

Other Databases showing IGFBPL1 gene

Specialized Databases showing IGFBPL1 gene

Intellectual Property
for IGFBPL1 gene

Products
for IGFBPL1 gene

View Random Gene

Advanced Search

Export list of displayed genes

IGFBPL1 Gene

Insulin-Like Growth Factor Binding Protein-Like 1

Aliasesfor IGFBPL1 gene

Summariesfor IGFBPL1 gene

Genomic Viewsfor IGFBPL1 gene

Proteinsfor IGFBPL1 gene

Protein Domains /Familiesfor IGFBPL1 gene

Functionfor IGFBPL1 gene

Pathways & Interactionsfor IGFBPL1 gene

Drugs & Compoundsfor IGFBPL1 gene

Transcriptsfor IGFBPL1 gene

Expression for IGFBPL1 gene

Orthologsfor IGFBPL1 gene

Paralogsfor IGFBPL1 gene

Genomic Variantsfor IGFBPL1 gene

Disorders / Diseasesfor IGFBPL1 gene

Publicationsfor IGFBPL1 gene

External Searches for IGFBPL1 gene

Genome Databases showing IGFBPL1 gene

Other Databases showing IGFBPL1 gene

Specialized Databases showing IGFBPL1 gene

Intellectual Propertyfor IGFBPL1 gene

Productsfor IGFBPL1 gene

View Random Gene

Aliases
for IGFBPL1 gene

Summaries
for IGFBPL1 gene

Genomic Views
for IGFBPL1 gene

Proteins
for IGFBPL1 gene

Protein Domains /
Families
for IGFBPL1 gene

Function
for IGFBPL1 gene

Pathways & Interactions
for IGFBPL1 gene

Drugs & Compounds
for IGFBPL1 gene

Transcripts
for IGFBPL1 gene

Expression
for IGFBPL1 gene

Orthologs
for IGFBPL1 gene

Paralogs
for IGFBPL1 gene

Genomic Variants
for IGFBPL1 gene

Disorders / Diseases
for IGFBPL1 gene

Publications
for IGFBPL1 gene

Intellectual Property
for IGFBPL1 gene

Products
for IGFBPL1 gene