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Aliases for IGFBPL1 Gene

Aliases for IGFBPL1 Gene

  • Insulin Like Growth Factor Binding Protein-Like 1 2 3 5
  • Insulin-Like Growth Factor-Binding-Related Protein 4 3 4
  • Insulin-Like Growth Factor Binding Protein-Like 1 2 3
  • IGFBP-Related Protein 10 3 4
  • IGFBP-RP4 3 4
  • IGFBPRP4 3 4
  • Insulin-Like Growth Factor Binding Protein Related Protein 4 3
  • BA113O24.1 3

External Ids for IGFBPL1 Gene

Previous GeneCards Identifiers for IGFBPL1 Gene

  • GC09M038399

Summaries for IGFBPL1 Gene

GeneCards Summary for IGFBPL1 Gene

IGFBPL1 (Insulin Like Growth Factor Binding Protein-Like 1) is a Protein Coding gene. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is KAZALD1.

UniProtKB/Swiss-Prot for IGFBPL1 Gene

  • IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBPL1 Gene

Genomics for IGFBPL1 Gene

Regulatory Elements for IGFBPL1 Gene

Enhancers for IGFBPL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IGFBPL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGFBPL1 Gene

Chromosome:
9
Start:
38,406,528 bp from pter
End:
38,424,447 bp from pter
Size:
17,920 bases
Orientation:
Minus strand

Genomic View for IGFBPL1 Gene

Genes around IGFBPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBPL1 Gene

Proteins for IGFBPL1 Gene

  • Protein details for IGFBPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WX77-IBPL1_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein-like 1
    Protein Accession:
    Q8WX77

    Protein attributes for IGFBPL1 Gene

    Size:
    278 amino acids
    Molecular mass:
    29005 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGFBPL1 Gene

Proteomics data for IGFBPL1 Gene at MOPED

Post-translational modifications for IGFBPL1 Gene

  • Glycosylation at Asn 166 and Ser 268
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBPL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFBPL1 Gene

Domains & Families for IGFBPL1 Gene

Gene Families for IGFBPL1 Gene

Suggested Antigen Peptide Sequences for IGFBPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WX77

UniProtKB/Swiss-Prot:

IBPL1_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with IGFBPL1: view

Function for IGFBPL1 Gene

Molecular function for IGFBPL1 Gene

UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.
UniProtKB/Swiss-Prot Induction:
Down-regulated in multiple tumors.

Phenotypes for IGFBPL1 Gene

genes like me logo Genes that share phenotypes with IGFBPL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFBPL1

CRISPR Products

miRNA for IGFBPL1 Gene

miRTarBase miRNAs that target IGFBPL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFBPL1 Gene

Localization for IGFBPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBPL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFBPL1 Gene COMPARTMENTS Subcellular localization image for IGFBPL1 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for IGFBPL1 Gene

Pathways & Interactions for IGFBPL1 Gene

SuperPathways for IGFBPL1 Gene

No Data Available

Interacting Proteins for IGFBPL1 Gene

Gene Ontology (GO) - Biological Process for IGFBPL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGFBPL1 Gene

Drugs & Compounds for IGFBPL1 Gene

No Compound Related Data Available

Transcripts for IGFBPL1 Gene

mRNA/cDNA for IGFBPL1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFBPL1 Gene

Insulin-like growth factor binding protein-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBPL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3:

Relevant External Links for IGFBPL1 Gene

GeneLoc Exon Structure for
IGFBPL1
ECgene alternative splicing isoforms for
IGFBPL1

Expression for IGFBPL1 Gene

mRNA expression in normal human tissues for IGFBPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBPL1 Gene

This gene is overexpressed in Artery - Aorta (x7.0) and Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for IGFBPL1 Gene

This gene is overexpressed in Amniocyte (50.2), Fetal Brain (11.7), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGFBPL1 Gene



SOURCE GeneReport for Unigene cluster for IGFBPL1 Gene Hs.349705

mRNA Expression by UniProt/SwissProt for IGFBPL1 Gene

Q8WX77-IBPL1_HUMAN
Tissue specificity: Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung.
genes like me logo Genes that share expression patterns with IGFBPL1: view

Primer Products

No data available for Protein tissue co-expression partners for IGFBPL1 Gene

Orthologs for IGFBPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBPL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IGFBPL1 35
  • 83.14 (n)
  • 83.79 (a)
IGFBPL1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igfbpl1 35
  • 81.61 (n)
  • 78.57 (a)
Igfbpl1 16
Igfbpl1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IGFBPL1 35
  • 99.64 (n)
  • 100 (a)
IGFBPL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igfbpl1 35
  • 80.03 (n)
  • 77.38 (a)
dog
(Canis familiaris)
Mammalia IGFBPL1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFBPL1 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBPL1 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia IGFBPL1 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbpl1 35
  • 59.9 (n)
  • 55.07 (a)
zebrafish
(Danio rerio)
Actinopterygii kazald2 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for IGFBPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBPL1 Gene

ENSEMBL:
Gene Tree for IGFBPL1 (if available)
TreeFam:
Gene Tree for IGFBPL1 (if available)

Paralogs for IGFBPL1 Gene

Paralogs for IGFBPL1 Gene

(1) SIMAP similar genes for IGFBPL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGFBPL1: view

Variants for IGFBPL1 Gene

Sequence variations from dbSNP and Humsavar for IGFBPL1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7848277 -- 38,410,267(+) catga(A/T)gtcgg intron-variant
rs7848283 -- 38,410,279(+) AGATC(A/G)AGACC intron-variant
rs7848359 -- 38,410,210(+) AGGCA(C/T)GGTGG intron-variant
rs7848589 -- 38,410,271(+) aagtc(A/G)ggaga intron-variant
rs7848816 -- 38,410,438(+) AGATC(A/G)CACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFBPL1 Gene

Variant ID Type Subtype PubMed ID
nsv8445 CNV Gain+Loss 18304495
esv34172 CNV Loss 18971310
nsv6537 CNV Insertion 18451855

Variation tolerance for IGFBPL1 Gene

Gene Damage Index Score: 3.14; 51.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IGFBPL1 Gene

Disorders for IGFBPL1 Gene

Relevant External Links for IGFBPL1

Genetic Association Database (GAD)
IGFBPL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFBPL1

No disorders were found for IGFBPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGFBPL1 Gene

Publications for IGFBPL1 Gene

  1. Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties. (PMID: 15845387) Cai Z. … Dedera D.A. (Biochem. Biophys. Res. Commun. 2005) 3 4 67
  2. Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes. (PMID: 17634530) Smith P. … Crook T. (Clin. Cancer Res. 2007) 3
  3. Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells. (PMID: 17884839) Kutsukake M. … Tamura K. (Mol. Hum. Reprod. 2007) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for IGFBPL1 Gene

Sources for IGFBPL1 Gene

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