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Aliases for IGFBPL1 Gene

Aliases for IGFBPL1 Gene

  • Insulin Like Growth Factor Binding Protein Like 1 2 3 5
  • Insulin-Like Growth Factor-Binding-Related Protein 4 3 4
  • IGFBP-Related Protein 10 3 4
  • IGFBP-RP4 3 4
  • IGFBPRP4 3 4
  • Insulin-Like Growth Factor Binding Protein Related Protein 4 3
  • Insulin-Like Growth Factor Binding Protein-Like 1 2
  • Insulin Like Growth Factor Binding Protein-Like 1 2
  • Insulin-Like Growth Factor-Binding Protein-Like 1 3
  • BA113O24.1 3

External Ids for IGFBPL1 Gene

Previous GeneCards Identifiers for IGFBPL1 Gene

  • GC09M038399

Summaries for IGFBPL1 Gene

GeneCards Summary for IGFBPL1 Gene

IGFBPL1 (Insulin Like Growth Factor Binding Protein Like 1) is a Protein Coding gene. Diseases associated with IGFBPL1 include Umbilical Hernia. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is IGFBP7.

UniProtKB/Swiss-Prot for IGFBPL1 Gene

  • IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.

Additional gene information for IGFBPL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBPL1 Gene

Genomics for IGFBPL1 Gene

GeneHancer (GH) Regulatory Elements for IGFBPL1 Gene

Promoters and enhancers for IGFBPL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I038423 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 -0.1 -72 1.1 MXI1 RNF2 HLF NFYC SIN3A ZBTB8A E2F1 POLR2A MXD3 IGFBPL1 LOC105376041
GH09I038379 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +37.2 37222 15.1 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ALDH1B1 IGFBPL1 SLC25A51 LOC105376040
GH09I038437 Enhancer 1 Ensembl ENCODE 17.2 -13.0 -13020 1.7 ELF3 FOXA2 ARID4B DMAP1 RAD21 ZNF48 ZSCAN9 ETS1 YY1 CREM IGFBPL1 ALDH1B1 TCEA1P3 ENSG00000283162 ARMC8P1
GH09I038420 Enhancer 0.7 ENCODE 16.7 +2.6 2631 1.9 PKNOX1 RFX1 ZBTB8A BMI1 ZIC2 GATA3 PRDM6 POLR2A ZNF341 RCOR1 IGFBPL1 PIR62369
GH09I038434 Enhancer 0.7 ENCODE 15.1 -10.2 -10224 2.7 ELF3 SOX13 CTCF MXI1 SAP130 MAX CEBPG RARA SOX5 ZNF654 ENSG00000283162 IGFBPL1 ALDH1B1 TCEA1P3 ARMC8P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGFBPL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGFBPL1 gene promoter:

Genomic Locations for IGFBPL1 Gene

Genomic Locations for IGFBPL1 Gene
chr9:38,406,528-38,424,447
(GRCh38/hg38)
Size:
17,920 bases
Orientation:
Minus strand
chr9:38,408,991-38,424,444
(GRCh37/hg19)

Genomic View for IGFBPL1 Gene

Genes around IGFBPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBPL1 Gene

Proteins for IGFBPL1 Gene

  • Protein details for IGFBPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WX77-IBPL1_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein-like 1
    Protein Accession:
    Q8WX77

    Protein attributes for IGFBPL1 Gene

    Size:
    278 amino acids
    Molecular mass:
    29005 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGFBPL1 Gene

Post-translational modifications for IGFBPL1 Gene

  • Glycosylation at posLast=166166 and isoforms=268

Other Protein References for IGFBPL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for IGFBPL1

No data available for DME Specific Peptides for IGFBPL1 Gene

Domains & Families for IGFBPL1 Gene

Gene Families for IGFBPL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IGFBPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFBPL1: view

No data available for UniProtKB/Swiss-Prot for IGFBPL1 Gene

Function for IGFBPL1 Gene

Molecular function for IGFBPL1 Gene

UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.
UniProtKB/Swiss-Prot Induction:
Down-regulated in multiple tumors.

Gene Ontology (GO) - Molecular Function for IGFBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005520 insulin-like growth factor binding IEA --
genes like me logo Genes that share ontologies with IGFBPL1: view
genes like me logo Genes that share phenotypes with IGFBPL1: view

Animal Model Products

miRNA for IGFBPL1 Gene

miRTarBase miRNAs that target IGFBPL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFBPL1 Gene

Localization for IGFBPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBPL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBPL1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGFBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 15845387
genes like me logo Genes that share ontologies with IGFBPL1: view

Pathways & Interactions for IGFBPL1 Gene

SuperPathways for IGFBPL1 Gene

No Data Available

Interacting Proteins for IGFBPL1 Gene

Gene Ontology (GO) - Biological Process for IGFBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0071228 cellular response to tumor cell IEP 15845387
genes like me logo Genes that share ontologies with IGFBPL1: view

No data available for Pathways by source and SIGNOR curated interactions for IGFBPL1 Gene

Drugs & Compounds for IGFBPL1 Gene

No Compound Related Data Available

Transcripts for IGFBPL1 Gene

mRNA/cDNA for IGFBPL1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFBPL1 Gene

Insulin-like growth factor binding protein-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBPL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3:

Relevant External Links for IGFBPL1 Gene

GeneLoc Exon Structure for
IGFBPL1
ECgene alternative splicing isoforms for
IGFBPL1

Expression for IGFBPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFBPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBPL1 Gene

This gene is overexpressed in Artery - Aorta (x7.0) and Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for IGFBPL1 Gene

This gene is overexpressed in Amniocyte (50.2), Fetal Brain (11.7), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGFBPL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGFBPL1 Gene:

IGFBPL1

SOURCE GeneReport for Unigene cluster for IGFBPL1 Gene:

Hs.349705

mRNA Expression by UniProt/SwissProt for IGFBPL1 Gene:

Q8WX77-IBPL1_HUMAN
Tissue specificity: Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung.

Evidence on tissue expression from TISSUES for IGFBPL1 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with IGFBPL1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBPL1 Gene

Orthologs for IGFBPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBPL1 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia IGFBPL1 34
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGFBPL1 33 34
  • 83.14 (n)
mouse
(Mus musculus)
Mammalia Igfbpl1 33 16 34
  • 81.61 (n)
rat
(Rattus norvegicus)
Mammalia Igfbpl1 33
  • 80.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBPL1 34
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFBPL1 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia IGFBPL1 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbpl1 33
  • 59.9 (n)
zebrafish
(Danio rerio)
Actinopterygii kazald2 34
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
Species where no ortholog for IGFBPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBPL1 Gene

ENSEMBL:
Gene Tree for IGFBPL1 (if available)
TreeFam:
Gene Tree for IGFBPL1 (if available)

Paralogs for IGFBPL1 Gene

Paralogs for IGFBPL1 Gene

(1) SIMAP similar genes for IGFBPL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGFBPL1: view

Variants for IGFBPL1 Gene

Sequence variations from dbSNP and Humsavar for IGFBPL1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000127974 -- 38,414,000(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000444218 -- 38,425,662(-) C/T upstream_transcript_variant
rs1000451218 -- 38,410,591(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000512648 -- 38,406,567(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000632551 -- 38,424,323(-) CCGGCC/C coding_sequence_variant, frameshift

Structural Variations from Database of Genomic Variants (DGV) for IGFBPL1 Gene

Variant ID Type Subtype PubMed ID
esv34172 CNV loss 18971310
nsv1018488 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv478468 CNV novel sequence insertion 20440878
nsv6537 CNV insertion 18451855
nsv8445 CNV gain+loss 18304495

Variation tolerance for IGFBPL1 Gene

Gene Damage Index Score: 3.14; 51.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFBPL1 Gene

Human Gene Mutation Database (HGMD)
IGFBPL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBPL1 Gene

Disorders for IGFBPL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGFBPL1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
umbilical hernia
  • hernia, umbilical
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGFBPL1

genes like me logo Genes that share disorders with IGFBPL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBPL1 Gene

Publications for IGFBPL1 Gene

  1. Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties. (PMID: 15845387) Cai Z … Dedera DA (Biochemical and biophysical research communications 2005) 3 4 58
  2. A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits. (PMID: 22384028) Guo Y … Thomas NG (PloS one 2012) 44 58
  3. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang SJ … Fox CS (BMC medical genetics 2007) 44 58
  4. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 44 58
  5. Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes. (PMID: 17634530) Smith P … Crook T (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 3 58

Products for IGFBPL1 Gene

Sources for IGFBPL1 Gene

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