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IGFBPL1 Gene

protein-coding   GIFtS: 49
GCID: GC09M038396

Insulin-Like Growth Factor Binding Protein-Like 1
  See related diseases
at
MalaCards
 

Aliases
for IGFBPL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin-Like Growth Factor Binding Protein-Like 11 2     bA113O24.12
IGFBPRP42 3 5     Insulin-Like Growth Factor Binding Protein Related Protein 42
Insulin-Like Growth Factor-Binding-Related Protein 42 3     Insulin-Like Growth Factor-Binding Protein-Like 12
IGFBP-Related Protein 102 3     IGFBP-rP43
IGFBP-RP42     

External Ids:    HGNC: 200811   Entrez Gene: 3472522   Ensembl: ENSG000001371427   OMIM: 6104135   UniProtKB: Q8WX773   

Export aliases for IGFBPL1 gene to outside databases

Previous GC identifer: GC09M038399


Summaries
for IGFBPL1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGFBPL1 Gene:
IGFBPL1 (insulin-like growth factor binding protein-like 1) is a protein-coding gene. Diseases associated with IGFBPL1 include choroiditis, and hypertension. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is KAZALD1.

UniProtKB/Swiss-Prot: IBPL1_HUMAN, Q8WX77
Function: IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate
the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell
surface receptors (By similarity). May be a putative tumor suppressor protein




Genomic Views
for IGFBPL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGFBPL1 gene promoter:
         SRF   AhR   Egr-2   Nkx6-1   SRF (504 AA)   FOXJ2 (long isoform)   FOXJ2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGFBPL1 promoter sequence
   Search Chromatin IP Primers for IGFBPL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFBPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.1   Ensembl cytogenetic band:  9p13.1   HGNC cytogenetic band: 9p12

IGFBPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBPL1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M038396:  view genomic region     (about GC identifiers)

Start:
 38,408,991 bp from pter      End:
 38,424,444 bp from pter
Size:
 15,454 bases      Orientation:
 minus strand

Proteins
for IGFBPL1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IBPL1_HUMAN, Q8WX77 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein-like 1 precursor  
Size: 278 amino acids; 29005 Da

Explore the universe of human proteins at neXtProt for IGFBPL1: NX_Q8WX77

Explore proteomics data for IGFBPL1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn166, Ser268
  • Modification sites at PhosphoSitePlus

    • See IGFBPL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001007564.1  
    ENSEMBL proteins: 
     ENSP00000366923  

    IGFBPL1 Human Recombinant Protein Products:

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    IGFBPL1 Antibody Products:

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    Abcam antibodies for IGFBPL1
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    LSBio Antibodies in human, mouse, rat for IGFBPL1

    IGFBPL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for IGFBPL1
    Cloud-Clone Corp. CLIAs for IGFBPL1

    Domains /
    Families
    for IGFBPL1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR002350 Kazal_dom
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR011390 IGFBP_rP_mac25

    Graphical View of Domain Structure for InterPro Entry Q8WX77

    ProtoNet protein and cluster: Q8WX77

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: IBPL1_HUMAN, Q8WX77
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 Kazal-like domain


    IGFBPL1 for domains           About GeneDecksing


    Function
    for IGFBPL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBPL1_HUMAN, Q8WX77
    Function: IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate
    the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell
    surface receptors (By similarity). May be a putative tumor suppressor protein
    Induction: Down-regulated in multiple tumors

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005520insulin-like growth factor binding IEA--
         
    IGFBPL1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGFBPL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGFBPL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGFBPL1

    miRNA
    Products:            		miRTarBase miRNAs that target IGFBPL1:
    hsa-mir-148b-3p (MIRT019447)

    Block miRNA regulation of human, mouse, rat IGFBPL1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate IGFBPL1:
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-548n hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmid: IGFBPL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IGFBPL1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for IGFBPL1
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    GenScript: all cDNA clones in your preferred vector: IGFBPL1 (NM_001007563)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBPL1


    Localization
    for IGFBPL1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IBPL1_HUMAN, Q8WX77: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    IGFBPL1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for IGFBPL1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGFBPL1
    Interactions:

        Search GeneGlobe Interaction Network for IGFBPL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for IGFBPL1 (ENSP000003669234) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHADENSP000002589694STRING: ENSP00000258969
    HAPLN2ENSP000002550394STRING: ENSP00000255039
    LRRTM1ENSP000002950574STRING: ENSP00000295057
    OPTCENSP000003561914STRING: ENSP00000356191
    PDGFRLENSP000002516304STRING: ENSP00000251630
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--

    IGFBPL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IGFBPL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGFBPL1 (IBPL1)



    Transcripts
    for IGFBPL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IGFBPL1 gene: 
    NM_001007563.2  

    Unigene Cluster for IGFBPL1:

    Insulin-like growth factor binding protein-like 1
    Hs.349705  [show with all ESTs]
    Unigene Representative Sequence: NM_001007563
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377694(uc004aba.3)
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat IGFBPL1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate IGFBPL1:
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x hsa-miR-548n hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmid: IGFBPL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IGFBPL1
    Clone
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    OriGene ORF clones in mouse, rat for IGFBPL1
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    GenScript: all cDNA clones in your preferred vector: IGFBPL1 (NM_001007563)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBPL1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IGFBPL1
      QuantiTect SYBR Green Assays in human, mouse, rat IGFBPL1
      QuantiFast Probe-based Assays in human, mouse, rat IGFBPL1

    Additional mRNA sequence: 

    AK055716.1 AK131521.1 

    2 DOTS entries:

    DT.102823294  DT.95153867 

    Selected AceView cDNA sequences (see all 65):

    BQ899312 AI863108 CR607939 AA676754 AI424991 CR595424 AA598689 BE857533 
    AW089149 AK055716 AA620528 AI241940 H06382 Z38240 BM680087 AW016452 
    BM701473 AW088875 BQ425046 BE263253 BM716864 BQ681660 BX396151 BQ952280 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBPL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
    SP1:              -     -                                 
    SP2:                                      -               
    SP3:                                                      


    ECgene alternative splicing isoforms for IGFBPL1

    Expression
    for IGFBPL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGFBPL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTCACGAC
    IGFBPL1 Expression
    About this image


    IGFBPL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
    IGFBPL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    IGFBPL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.349705

    UniProtKB/Swiss-Prot: IBPL1_HUMAN, Q8WX77
    Tissue specificity: Expressed at the highest level in both brain and testis, with lower levels in the prostate,
    bladder and lung

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBPL1

    Orthologs
    for IGFBPL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBPL1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Igfbpl11 , 5 insulin-like growth factor binding protein-like 11, 5 81.61(n)1
    78.57(a)1    		   4 (24.36 cM)5
    754261  NM_018741.21  NP_061211.11 
     458094685 
    chicken
    (Gallus gallus)    		 Aves --
    		 Uncharacterized protein
    		 30(a)
    		 many ↔ many
    		 13(2832799-2846286)
    lizard
    (Anolis carolinensis)    		 Reptilia IGFBPL16
    		 insulin-like growth factor binding protein-like 1
    		 56(a)
    		 1 ↔ 1
    		 GL343201.1(3959797-4016237)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia igfbpl11 insulin-like growth factor binding protein-like 1 59.9(n)
    55.07(a)    		   100127182  XM_002940258.2  XP_002940304.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii kazald26
    		 Kazal-type serine peptidase inhibitor domain 2
    		 26(a)
    		 many ↔ many
    		 14(5811097-5823208) ENSDARG00000078518


    ENSEMBL Gene Tree for IGFBPL1 (if available)
    TreeFam Gene Tree for IGFBPL1 (if available)

    Paralogs
    for IGFBPL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGFBPL1 gene
    KAZALD12  IGFBP72  
    1 SIMAP similar gene for IGFBPL1 using alignment to 1 protein entry:     IBPL1_HUMAN:
    IGFBP7

    IGFBPL1 for paralogs           About GeneDecksing



    Genomic Variants
    for IGFBPL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for IGFBPL1 (see all 496)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs58977331,2
    		C--38381470(+) TTTCT-/ACACA/CACA/CTCA
    CACACACACACACACACA    cacac     		1 -- int1 trp30--------
    rs1930614591,2
    		--38406174(+) AACATA/TTGACT 1 -- ds50010--------
    rs109737891,2
    		C,F,A,H--38406178(+) TATGAC/TTTTCG 1 -- ds500127Minor allele frequency- T:0.18NA NS EA CSA WA 2914
    rs109737901,2
    		C,F--38406230(+) GTGTGA/G/TGAGGG 1 -- ds50017NA WA EA 366
    rs1829824271,2
    		--38406278(+) AATGCA/GTACAC 1 -- ds50010--------
    rs1480364111,2
    		--38406324(+) ATGATC/TAGGGC 1 -- ds50010--------
    rs109737911,2
    		C,F,H--38406339(+) TAAAAA/GTTTCG 1 -- ds500110Minor allele frequency- G:0.27EA NS NA WA CSA 534
    rs108146891,2
    		C,F,A,H--38406340(+) AAAAAT/CTTCGG 1 -- ds500110Minor allele frequency- C:0.26EA NS NA WA CSA 528
    rs107584961,2
    		C,F,A,H--38406367(+) GGCTGT/CGATCG 1 -- ds500111Minor allele frequency- C:0.48NA WA CSA EA 373
    rs1152278111,2
    		F--38406425(+) GGGCAT/GGCAGA 1 -- ds50011Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for IGFBPL1 (38408991 - 38424444 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IGFBPL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6537CNV Insertion18451855
    esv34172CNV Loss18971310
    nsv8445CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IGFBPL1
    DNA2.0 Custom Variant and Variant Library Synthesis for IGFBPL1

    Disorders / Diseases
    for IGFBPL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610413    OMIM disorders: --

    6 diseases for IGFBPL1:    
    About MalaCards
    choroiditis    hypertension    cerebritis    breast cancer
    prostatitis    endotheliitis


    IGFBPL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IGFBPL1

    Export disorders for IGFBPL1 gene to outside databases

    Publications
    for IGFBPL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGFBPL1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IGFBPL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties. (PubMed id 15845387)1, 2 Cai Z.... Dedera D.A. (Biochem. Biophys. Res. Commun. 2005)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits. (PubMed id 22384028)4 Guo Y....Thomas N.G. (PLoS ONE 2012)
    4. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    5. Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells. (PubMed id 17884839)1 Kutsukake M....Tamura K. (Mol. Hum. Reprod. 2007)
    6. Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes. (PubMed id 17634530)1 Smith P....Crook T. (Clin. Cancer Res. 2007)
    7. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)

    External Searches for IGFBPL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing IGFBPL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 347252 HGNC: 20081 AceView: IGFBPL1 Ensembl:ENSG00000137142 euGenes: HUgn347252
    ECgene: IGFBPL1 H-InvDB: IGFBPL1

    Other Databases showing IGFBPL1 gene

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    Specialized Databases showing IGFBPL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGFBPL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IGFBPL1 gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    TryGeneCards Plus    		Patent Information for IGFBPL1 gene:
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