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IGFBPL1 Gene(Protein Coding)

Insulin Like Growth Factor Binding Protein Like 1

GCID:
GC09M038396
GIFtS:
50
Genes Participants
UDN Logo

Aliases for IGFBPL1 Gene

Aliases for IGFBPL1 Gene

  • Insulin Like Growth Factor Binding Protein Like 1 2 3 5
  • Insulin-Like Growth Factor-Binding-Related Protein 4 3 4
  • IGFBP-Related Protein 10 3 4
  • IGFBP-RP4 3 4
  • IGFBPRP4 3 4
  • Insulin-Like Growth Factor Binding Protein Related Protein 4 3
  • Insulin-Like Growth Factor Binding Protein-Like 1 2
  • Insulin Like Growth Factor Binding Protein-Like 1 2
  • Insulin-Like Growth Factor-Binding Protein-Like 1 3
  • BA113O24.1 3

External Ids for IGFBPL1 Gene

Previous GeneCards Identifiers for IGFBPL1 Gene

  • GC09M038399

Summaries for IGFBPL1 Gene

GeneCards Summary for IGFBPL1 Gene

IGFBPL1 (Insulin Like Growth Factor Binding Protein Like 1) is a Protein Coding gene. Diseases associated with IGFBPL1 include Umbilical Hernia. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is IGFBP7.

UniProtKB/Swiss-Prot for IGFBPL1 Gene

  • IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBPL1 Gene

Genomics for IGFBPL1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for IGFBPL1 Gene

Enhancers for IGFBPL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G038379 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +37.2 37222 15.1 HDGF FOXA2 CREB3L1 MLX ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ALDH1B1 IGFBPL1 SLC25A51 LOC105376040
GH09G038437 1.1 Ensembl ENCODE 17.1 -13.0 -13020 1.7 ELF3 TBP FOXA2 ARID4B DMAP1 ZNF48 ZSCAN9 RAD21 YY1 GATA4 IGFBPL1 ALDH1B1 TCEA1P3 ENSG00000283162 ARMC8P1
GH09G038420 0.8 ENCODE 16.7 +2.6 2631 1.9 PKNOX1 MXI1 BMI1 ZIC2 GATA3 POLR2A SMC3 FOS FOSL2 ZNF600 IGFBPL1 PIR62369
GH09G038434 0.8 ENCODE 15.1 -10.2 -10224 2.7 ELF3 CTCF SOX13 MXI1 SAP130 ZNF175 MAX CEBPG RAD21 RARA IGFBPL1 ALDH1B1 TCEA1P3 ENSG00000283162 ARMC8P1
GH09G038073 1.2 Ensembl ENCODE dbSUPER 9.5 +349.8 349844 1.3 SOX5 ELF3 SOX13 FOXA2 TEAD1 SAP130 FOXA3 ZMYM3 ZNF16 TEAD3 IGFBPL1 LOC105376039 SHB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGFBPL1 on UCSC Golden Path with GeneCards custom track

Promoters for IGFBPL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234996 147 601 CTCF MXI1 SUZ12 SIN3A RBBP5 RAD21 E2F1 POLR2A EZH2 PHF8

Transcription factor binding sites by QIAGEN in the IGFBPL1 gene promoter:

Genomic Location for IGFBPL1 Gene

Chromosome:
9
Start:
38,406,528 bp from pter
End:
38,424,447 bp from pter
Size:
17,920 bases
Orientation:
Minus strand

Genomic View for IGFBPL1 Gene

Genes around IGFBPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBPL1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IGFBPL1 Gene

Proteins for IGFBPL1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IGFBPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WX77-IBPL1_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein-like 1
    Protein Accession:
    Q8WX77

    Protein attributes for IGFBPL1 Gene

    Size:
    278 amino acids
    Molecular mass:
    29005 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGFBPL1 Gene

Protein Expression for IGFBPL1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IGFBPL1 Gene

  • Glycosylation at posLast=166166 and isoforms=268
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBPL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFBPL1 Gene

Domains & Families for IGFBPL1 Gene

Gene Families for IGFBPL1 Gene

HGNC:

Protein Domains for IGFBPL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IGFBPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFBPL1: view

No data available for UniProtKB/Swiss-Prot for IGFBPL1 Gene

Function for IGFBPL1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IGFBPL1 Gene

UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.
UniProtKB/Swiss-Prot Induction:
Down-regulated in multiple tumors.

Gene Ontology (GO) - Molecular Function for IGFBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005520 insulin-like growth factor binding IEA --
genes like me logo Genes that share ontologies with IGFBPL1: view
genes like me logo Genes that share phenotypes with IGFBPL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFBPL1

CRISPR Products

miRNA for IGFBPL1 Gene

miRTarBase miRNAs that target IGFBPL1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFBPL1 Gene

Localization for IGFBPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBPL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBPL1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for IGFBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGFBPL1: view

Pathways & Interactions for IGFBPL1 Gene

SuperPathways for IGFBPL1 Gene

PathCards logo More details on SuperPathways for IGFBPL1
No Data Available

Interacting Proteins for IGFBPL1 Gene

Selected Interacting proteins: Q8WX77-IBPL1_HUMAN for IGFBPL1 Gene via IID

Gene Ontology (GO) - Biological Process for IGFBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
genes like me logo Genes that share ontologies with IGFBPL1: view

No data available for Pathways by source and SIGNOR curated interactions for IGFBPL1 Gene

Drugs & Compounds for IGFBPL1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IGFBPL1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IGFBPL1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFBPL1 Gene

Insulin-like growth factor binding protein-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBPL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3:

Relevant External Links for IGFBPL1 Gene

GeneLoc Exon Structure for
IGFBPL1
ECgene alternative splicing isoforms for
IGFBPL1

Expression for IGFBPL1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFBPL1 Gene

mRNA expression in normal human tissues for IGFBPL1 Gene
mRNA expression by BioGPS for IGFBPL1 GenemRNA expression by GTEx for IGFBPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBPL1 Gene

This gene is overexpressed in Artery - Aorta (x7.0) and Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for IGFBPL1 Gene

This gene is overexpressed in Amniocyte (50.2), Fetal Brain (11.7), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGFBPL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGFBPL1 Gene:

IGFBPL1

SOURCE GeneReport for Unigene cluster for IGFBPL1 Gene:

Hs.349705

mRNA Expression by UniProt/SwissProt for IGFBPL1 Gene:

Q8WX77-IBPL1_HUMAN
Tissue specificity: Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung.

Evidence on tissue expression from TISSUES for IGFBPL1 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with IGFBPL1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBPL1 Gene

Orthologs for IGFBPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IGFBPL1 34 35
  • 99.64 (n)
dog
(Canis familiaris)
 Mammalia IGFBPL1 35
  • 85 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia IGFBPL1 34 35
  • 83.14 (n)
mouse
(Mus musculus)
 Mammalia Igfbpl1 34 16 35
  • 81.61 (n)
rat
(Rattus norvegicus)
 Mammalia Igfbpl1 34
  • 80.03 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia IGFBPL1 35
  • 64 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia IGFBPL1 35
  • 58 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves -- 35
  • 30 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia IGFBPL1 35
  • 56 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia igfbpl1 34
  • 59.9 (n)
zebrafish
(Danio rerio)
 Actinopterygii kazald2 35
  • 26 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 28 (a)
 OneToMany
Species where no ortholog for IGFBPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBPL1 Gene

ENSEMBL:
Gene Tree for IGFBPL1 (if available)
TreeFam:
Gene Tree for IGFBPL1 (if available)

Paralogs for IGFBPL1 Gene

Paralogs for IGFBPL1 Gene

(1) SIMAP similar genes for IGFBPL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGFBPL1: view

Variants for IGFBPL1 Gene

Sequence variations from dbSNP and Humsavar for IGFBPL1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000127974 -- 38,414,000(+) AAACA(C/T)TTTTA intron-variant, downstream-variant-500B
rs1000444218 -- 38,425,662(+) CCACC(C/T)CTCAT intron-variant, upstream-variant-2KB
rs1000451218 -- 38,410,591(+) GGACA(G/T)GTTCC intron-variant
rs1000512648 -- 38,406,567(+) GGGGT(C/T)GTGAC utr-variant-3-prime
rs1000632551 -- 38,424,323(+) GGGCG(-/CCGGC)CGCCC upstream-variant-2KB, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFBPL1 Gene

Variant ID Type Subtype PubMed ID
esv34172 CNV loss 18971310
nsv1018488 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv478468 CNV novel sequence insertion 20440878
nsv6537 CNV insertion 18451855
nsv8445 CNV gain+loss 18304495

Variation tolerance for IGFBPL1 Gene

Gene Damage Index Score: 3.14; 51.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFBPL1 Gene

Human Gene Mutation Database (HGMD)
IGFBPL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBPL1 Gene

Disorders for IGFBPL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGFBPL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
umbilical hernia
  • hernia, umbilical
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGFBPL1

Genetic Association Database (GAD)
IGFBPL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFBPL1
genes like me logo Genes that share disorders with IGFBPL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBPL1 Gene

Publications for IGFBPL1 Gene

  1. Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties. (PMID: 15845387) Cai Z. … Dedera D.A. (Biochem. Biophys. Res. Commun. 2005) 3 4 64
  2. A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits. (PMID: 22384028) Guo Y. … Thomas N.G. (PLoS ONE 2012) 46 64
  3. Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes. (PMID: 17634530) Smith P. … Crook T. (Clin. Cancer Res. 2007) 3 64
  4. Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells. (PMID: 17884839) Kutsukake M. … Tamura K. (Mol. Hum. Reprod. 2007) 3 64
  5. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang S.J. … Fox C.S. (BMC Med. Genet. 2007) 46 64

Products for IGFBPL1 Gene

Sources for IGFBPL1 Gene

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