Aliases for IGFBPL1 Gene
Aliases for IGFBPL1 Gene
External Ids for IGFBPL1 Gene
- HGNC: 20081
- Entrez Gene: 347252
- Ensembl: ENSG00000137142
- OMIM: 610413
- UniProtKB: Q8WX77
Previous GeneCards Identifiers for IGFBPL1 Gene
- GC09M038399
Summaries for IGFBPL1 Gene
GeneCards Summary for IGFBPL1 Gene
IGFBPL1 (Insulin Like Growth Factor Binding Protein-Like 1) is a Protein Coding gene. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is KAZALD1.
UniProtKB/Swiss-Prot for IGFBPL1 Gene
-
IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBPL1 Gene
Genomics for IGFBPL1 Gene
Regulatory Elements for IGFBPL1 Gene
Enhancers for IGFBPL1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around IGFBPL1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the IGFBPL1 gene promoter:
Regulatory Element Products
Genomic Location for IGFBPL1 Gene
- Chromosome:
- 9
- Start:
- 38,406,528 bp from pter
- End:
- 38,424,447 bp from pter
- Size:
- 17,920 bases
- Orientation:
- Minus strand
Genomic View for IGFBPL1 Gene
Genes around IGFBPL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p13.1 by Ensembl
- 9p13.1 by Entrez Gene
- 9p12 by HGNC
IGFBPL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGFBPL1 Gene
Proteins for IGFBPL1 Gene
-
Protein details for IGFBPL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WX77-IBPL1_HUMAN
- Recommended name:
- Insulin-like growth factor-binding protein-like 1
- Protein Accession:
- Q8WX77
Protein attributes for IGFBPL1 Gene
- Size:
- 278 amino acids
- Molecular mass:
- 29005 Da
- Quaternary structure:
- No Data Available
Protein Expression for IGFBPL1 Gene
Post-translational modifications for IGFBPL1 Gene
Other Protein References for IGFBPL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IGFBPL1 (IGFBP-L1)
-
Custom Antibody ServicesOriGene Antibodies for IGFBPL1
- Novus Biologicals Antibodies for IGFBPL1
- Search GeneTex for Antibodies for IGFBPL1
Protein Products
-
OriGene Purified Proteins for IGFBPL1
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFBPL1
- Origene Custom Protein Services for IGFBPL1
- Search GeneTex for Proteins for IGFBPL1
Assay Products
No data available for DME Specific Peptides for IGFBPL1 Gene
Domains & Families for IGFBPL1 Gene
Gene Families for IGFBPL1 Gene
Protein Domains for IGFBPL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IGFBPL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WX77- Domain:
-
- Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
- Contains 1 IGFBP N-terminal domain.
- Contains 1 Kazal-like domain.
Function for IGFBPL1 Gene
Molecular function for IGFBPL1 Gene
- UniProtKB/Swiss-Prot Function:
- IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in multiple tumors.
Phenotypes for IGFBPL1 Gene
- GenomeRNAi human phenotypes for IGFBPL1:
Animal Model Products
-
Taconic Biosciences Mouse Models for IGFBPL1
-
ViGene Biosciences lentiviral particle packaged cDNA for IGFBPL1 gene
- Search ViGene Biosciences for IGFBPL1
CRISPR Products
-
OriGene CRISPR knockouts for IGFBPL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBPL1
- GenScript: Design CRISPR guide RNA sequences for IGFBPL1
miRNA for IGFBPL1 Gene
- miRTarBase miRNAs that target IGFBPL1
miRNA Products
- Search ViGene Biosciences for IGFBPL1
Clone Products
- OriGene clones in human for IGFBPL1
- OriGene ORF clones in human,mouse,rat for IGFBPL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for IGFBPL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IGFBPL1 gene
- Search ViGene Biosciences for IGFBPL1
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFBPL1 Gene
Localization for IGFBPL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGFBPL1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 2 |
| plasma membrane | 2 |
No data available for Gene Ontology (GO) - Cellular Components for IGFBPL1 Gene
More details on SuperPathways for IGFBPL1Transcripts for IGFBPL1 Gene
mRNA/cDNA for IGFBPL1 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (65) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IGFBPL1 Gene
- Insulin-like growth factor binding protein-like 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for IGFBPL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBPL1
- GenScript: Design CRISPR guide RNA sequences for IGFBPL1
miRNA Products
- Search ViGene Biosciences for IGFBPL1
Clone Products
- OriGene clones in human for IGFBPL1
- OriGene ORF clones in human,mouse,rat for IGFBPL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: |
Expression for IGFBPL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Choroid Plexus Progenitor Cells Choroid Plexus
- Endothelial Cells Blood Brain Barrier
- Hypothalamus
- Thalamus
- Striatum
- Neural Tube (Nervous System)
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Gut Tube (Gastrointestinal Tract)
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for IGFBPL1 Gene
This gene is overexpressed in Artery - Aorta (x7.0) and Artery - Tibial (x5.4).
This gene is overexpressed in Amniocyte (50.2), Fetal Brain (11.7), and Pancreas (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGFBPL1 Gene
SOURCE GeneReport for Unigene cluster for IGFBPL1 Gene Hs.349705
mRNA Expression by UniProt/SwissProt for IGFBPL1 Gene
Q8WX77-IBPL1_HUMAN
Tissue specificity:
Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung.
Primer Products
-
OriGene qPCR primer pairs for IGFBPL1
No data available for Protein tissue co-expression partners for IGFBPL1 Gene
Orthologs for IGFBPL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | IGFBPL1 35 |
|
||
| IGFBPL1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Igfbpl1 35 |
|
||
| Igfbpl1 16 |
|
||||
| Igfbpl1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | IGFBPL1 35 |
|
||
| IGFBPL1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Igfbpl1 35 |
|
||
| dog (Canis familiaris) |
Mammalia | IGFBPL1 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | IGFBPL1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IGFBPL1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 36 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | IGFBPL1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | igfbpl1 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | kazald2 36 |
|
ManyToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for IGFBPL1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IGFBPL1 Gene
(1) SIMAP similar genes for IGFBPL1 Gene using alignment to 1 proteins:
Variants for IGFBPL1 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs7848277 | -- | 38,410,267(+) | catga(A/T)gtcgg | intron-variant | |
| rs7848283 | -- | 38,410,279(+) | AGATC(A/G)AGACC | intron-variant | |
| rs7848359 | -- | 38,410,210(+) | AGGCA(C/T)GGTGG | intron-variant | |
| rs7848589 | -- | 38,410,271(+) | aagtc(A/G)ggaga | intron-variant | |
| rs7848816 | -- | 38,410,438(+) | AGATC(A/G)CACCA | intron-variant |
Gene Damage Index Score:
3.14;
51.42% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IGFBPL1 Gene
Disorders for IGFBPL1 Gene
Relevant External Links for IGFBPL1
No disorders were found for IGFBPL1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGFBPL1 Gene
Publications for IGFBPL1 Gene
- Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties. (PMID: 15845387) Cai Z. … Dedera D.A. (Biochem. Biophys. Res. Commun. 2005) 3 4 67
- Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes. (PMID: 17634530) Smith P. … Crook T. (Clin. Cancer Res. 2007) 3
- Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells. (PMID: 17884839) Kutsukake M. … Tamura K. (Mol. Hum. Reprod. 2007) 3
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
Products for IGFBPL1 Gene
- R&D Systems Antibodies for IGFBPL1 (IGFBP-L1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for IGFBPL1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for IGFBPL1
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFBPL1
- Origene Custom Protein Services for IGFBPL1
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for IGFBPL1
- Browse OriGene Inhibitory RNA Products For IGFBPL1
- OriGene qPCR primer pairs for IGFBPL1
- OriGene CRISPR knockouts for IGFBPL1
- OriGene clones in human for IGFBPL1
- OriGene ORF clones in human,mouse,rat for IGFBPL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for IGFBPL1
- GenScript Custom Assay Services for IGFBPL1
- GenScript Custom overexpressing Cell Line Services for IGFBPL1
- GenScript: Design CRISPR guide RNA sequences for IGFBPL1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IGFBPL1
- Taconic Biosciences Mouse Models for IGFBPL1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for IGFBPL1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for IGFBPL1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for IGFBPL1 gene
- Search ViGene Biosciences for IGFBPL1
- Search ViGene Biosciences for IGFBPL1
- Search ViGene Biosciences for IGFBPL1
- Search ViGene Biosciences for IGFBPL1
Sources for IGFBPL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon