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Aliases for IGFBPL1 Gene

Aliases for IGFBPL1 Gene

  • Insulin-Like Growth Factor Binding Protein-Like 1 2 3
  • IGFBPRP4 3 4 6
  • Insulin-Like Growth Factor-Binding-Related Protein 4 3 4
  • IGFBP-Related Protein 10 3 4
  • IGFBP-RP4 3 4
  • Insulin-Like Growth Factor Binding Protein Related Protein 4 3
  • Insulin-Like Growth Factor-Binding Protein-Like 1 3
  • BA113O24.1 3

External Ids for IGFBPL1 Gene

Summaries for IGFBPL1 Gene

GeneCards Summary for IGFBPL1 Gene

IGFBPL1 (Insulin-Like Growth Factor Binding Protein-Like 1) is a Protein Coding gene. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is IGFBP7.

UniProtKB/Swiss-Prot for IGFBPL1 Gene

  • IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBPL1 Gene

Genomics for IGFBPL1 Gene

Genomic Location for IGFBPL1 Gene

Start:
38,406,528 bp from pter
End:
38,424,447 bp from pter
Size:
17,920 bases
Orientation:
Minus strand

Genomic View for IGFBPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGFBPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBPL1 Gene

Regulatory Elements for IGFBPL1 Gene

Proteins for IGFBPL1 Gene

  • Protein details for IGFBPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WX77-IBPL1_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein-like 1
    Protein Accession:
    Q8WX77
    Secondary Accessions:

    Protein attributes for IGFBPL1 Gene

    Size:
    278 amino acids
    Molecular mass:
    29005 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGFBPL1 Gene

Proteomics data for IGFBPL1 Gene at MOPED

Post-translational modifications for IGFBPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn166 and Ser268

Other Protein References for IGFBPL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFBPL1 Gene

Domains for IGFBPL1 Gene

Gene Families for IGFBPL1 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

UniProtKB/Swiss-Prot:

IBPL1_HUMAN
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q8WX77
  • Contains 1 IGFBP N-terminal domain.:
    • Q8WX77
  • Contains 1 Kazal-like domain.:
    • Q8WX77
genes like me logo Genes that share domains with IGFBPL1: view

Function for IGFBPL1 Gene

Molecular function for IGFBPL1 Gene

UniProtKB/Swiss-Prot Function: IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein.
UniProtKB/Swiss-Prot Induction: Down-regulated in multiple tumors

Gene Ontology (GO) - Molecular Function for IGFBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005520 insulin-like growth factor binding IEA --
genes like me logo Genes that share ontologies with IGFBPL1: view

miRNA for IGFBPL1 Gene

miRTarBase miRNAs that target IGFBPL1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGFBPL1 Gene

Localization for IGFBPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBPL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFBPL1 Gene COMPARTMENTS Subcellular localization image for IGFBPL1 gene
Compartment Confidence
extracellular 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for IGFBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGFBPL1: view

Pathways for IGFBPL1 Gene

SuperPathways for IGFBPL1 Gene

No Data Available

Interacting Proteins for IGFBPL1 Gene

Gene Ontology (GO) - Biological Process for IGFBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
genes like me logo Genes that share ontologies with IGFBPL1: view

No data available for Pathways by source for IGFBPL1 Gene

Transcripts for IGFBPL1 Gene

mRNA/cDNA for IGFBPL1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFBPL1 Gene

Insulin-like growth factor binding protein-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBPL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3:

Relevant External Links for IGFBPL1 Gene

GeneLoc Exon Structure for
IGFBPL1
ECgene alternative splicing isoforms for
IGFBPL1

Expression for IGFBPL1 Gene

mRNA expression in normal human tissues for IGFBPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBPL1 Gene

This gene is overexpressed in Artery - Aorta (7.0) and Artery - Tibial (5.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGFBPL1 Gene

SOURCE GeneReport for Unigene cluster for IGFBPL1 Gene Hs.349705

mRNA Expression by UniProt/SwissProt for IGFBPL1 Gene

Q8WX77-IBPL1_HUMAN
Tissue specificity: Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung.
genes like me logo Genes that share expressions with IGFBPL1: view

Orthologs for IGFBPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBPL1 36
  • 99.64 (n)
  • 100 (a)
IGFBPL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGFBPL1 36
  • 83.14 (n)
  • 83.79 (a)
IGFBPL1 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGFBPL1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igfbpl1 36
  • 81.61 (n)
  • 78.57 (a)
Igfbpl1 16
Igfbpl1 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFBPL1 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBPL1 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igfbpl1 36
  • 80.03 (n)
  • 77.38 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia IGFBPL1 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbpl1 36
  • 59.9 (n)
  • 55.07 (a)
zebrafish
(Danio rerio)
Actinopterygii kazald2 37
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
OneToMany
Species with no ortholog for IGFBPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBPL1 Gene

ENSEMBL:
Gene Tree for IGFBPL1 (if available)
TreeFam:
Gene Tree for IGFBPL1 (if available)

Paralogs for IGFBPL1 Gene

Paralogs for IGFBPL1 Gene

Selected SIMAP similar genes for IGFBPL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGFBPL1: view

Variants for IGFBPL1 Gene

Sequence variations from dbSNP and Humsavar for IGFBPL1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs11361 -- 38,406,593(-) TCTAC(C/T)GTTTT utr-variant-3-prime
rs16402 -- 38,406,791(+) ATTAA(-/TTAT)ATTAT utr-variant-3-prime
rs1467574 -- 38,421,978(+) CCCTG(A/G)GTCTG intron-variant
rs1467575 -- 38,422,048(+) TCATT(C/T)GGTAA intron-variant
rs1475102 -- 38,407,093(+) CAGGC(C/T)TTCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IGFBPL1 Gene

Variant ID Type Subtype PubMed ID
nsv8445 CNV Gain+Loss 18304495
esv34172 CNV Loss 18971310
nsv6537 CNV Insertion 18451855

Relevant External Links for IGFBPL1 Gene

HapMap Linkage Disequilibrium report
IGFBPL1

Disorders for IGFBPL1 Gene

Relevant External Links for IGFBPL1

Genetic Association Database (GAD)
IGFBPL1
genes like me logo Genes that share disorders with IGFBPL1: view

No data available for UniProtKB/Swiss-Prot for IGFBPL1 Gene

Publications for IGFBPL1 Gene

  1. Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties. (PMID: 15845387) Cai Z. … Dedera D.A. (Biochem. Biophys. Res. Commun. 2005) 3 4
  2. Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes. (PMID: 17634530) Smith P. … Crook T. (Clin. Cancer Res. 2007) 3
  3. Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells. (PMID: 17884839) Kutsukake M. … Tamura K. (Mol. Hum. Reprod. 2007) 3
  4. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang S.J. … Fox C.S. (BMC Med. Genet. 2007) 49
  5. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 49

Products for IGFBPL1 Gene

Sources for IGFBPL1 Gene

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