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Aliases for IGFBP7 Gene

Aliases for IGFBP7 Gene

  • Insulin Like Growth Factor Binding Protein 7 2 3 5
  • Prostacyclin-Stimulating Factor 3 4
  • Tumor-Derived Adhesion Factor 3 4
  • PGI2-Stimulating Factor 3 4
  • IGF-Binding Protein 7 3 4
  • IGFBP-RP1 3 4
  • IGFBP-7 3 4
  • IBP-7 3 4
  • MAC25 3 4
  • PSF 3 4
  • TAF 3 4
  • Insulin-Like Growth Factor Binding Protein 7 2
  • Insulin-Like Growth Factor-Binding Protein 7 3
  • MAC25 Protein 4
  • Angiomodulin 3
  • IGFBP-7v 3
  • IGFBPRP1 3
  • FSTL2 3
  • AGM 3

External Ids for IGFBP7 Gene

Previous GeneCards Identifiers for IGFBP7 Gene

  • GC04M057701
  • GC04M057893
  • GC04M057812
  • GC04M057738
  • GC04M057592
  • GC04M053850
  • GC04M057897

Summaries for IGFBP7 Gene

Entrez Gene Summary for IGFBP7 Gene

  • This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

GeneCards Summary for IGFBP7 Gene

IGFBP7 (Insulin Like Growth Factor Binding Protein 7) is a Protein Coding gene. Diseases associated with IGFBP7 include Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis and Diabetic Angiopathy. Among its related pathways are Cellular Senescence (REACTOME) and Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is IGFBPL1.

UniProtKB/Swiss-Prot for IGFBP7 Gene

  • Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

Gene Wiki entry for IGFBP7 Gene

Additional gene information for IGFBP7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP7 Gene

Genomics for IGFBP7 Gene

GeneHancer (GH) Regulatory Elements for IGFBP7 Gene

Promoters and enhancers for IGFBP7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I057107 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 557.5 +0.6 564 5.6 LEF1 ZNF223 MAX SIN3A FEZF1 ZIC2 HIC1 ZNF335 ZFHX2 POLR2A IGFBP7-AS1 IGFBP7
GH04I057073 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +31.3 31297 10.9 PKNOX1 SIN3A FEZF1 ZNF2 ZNF121 ZNF213 FOS RXRA TSHZ1 REST IGFBP7 IGFBP7-AS1 RNU6-998P UBE2CP3
GH04I057070 Enhancer 0.8 Ensembl ENCODE dbSUPER 18.9 +39.2 39206 1.4 PRDM6 CEBPB UBE2CP3 IGFBP7 IGFBP7-AS1 RNU6-998P
GH04I057163 Enhancer 1.1 Ensembl ENCODE 11.8 -53.6 -53575 1.6 ELF3 ATF1 RB1 MZF1 SIN3A ZNF2 ZNF48 RAD21 ZEB1 ZNF335 IGFBP7 IGFBP7-AS1 RNU6-998P ENSG00000250192 GC04P057230
GH04I057101 Enhancer 1.2 Ensembl ENCODE dbSUPER 7.3 +6.9 6894 4.7 FOXA2 ARID4B THRB RARA ZNF335 HMG20B RXRA REST NR2F2 KAT8 POLR2B NOA1 IGFBP7-AS1 IGFBP7 UBE2CP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGFBP7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGFBP7 gene promoter:

Genomic Locations for IGFBP7 Gene

Genomic Locations for IGFBP7 Gene
79,613 bases
Minus strand

Genomic View for IGFBP7 Gene

Genes around IGFBP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP7 Gene

Proteins for IGFBP7 Gene

  • Protein details for IGFBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin-like growth factor-binding protein 7
    Protein Accession:
    Secondary Accessions:
    • B4E1N2
    • B7Z9W7
    • Q07822
    • Q53YE6
    • Q9UCA8

    Protein attributes for IGFBP7 Gene

    282 amino acids
    Molecular mass:
    29130 Da
    Quaternary structure:
    • May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.

    Alternative splice isoforms for IGFBP7 Gene


neXtProt entry for IGFBP7 Gene

Post-translational modifications for IGFBP7 Gene

  • N-glycosylated.
  • Glycosylation at isoforms=2171, isoforms=2206, isoforms=2220, posLast=236236, and posLast=264264

Other Protein References for IGFBP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFBP7 Gene

Domains & Families for IGFBP7 Gene

Gene Families for IGFBP7 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IGFBP7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFBP7: view

No data available for UniProtKB/Swiss-Prot for IGFBP7 Gene

Function for IGFBP7 Gene

Molecular function for IGFBP7 Gene

GENATLAS Biochemistry:
insuline-like growth factor binding protein 7 (related protein 1),expressed in both in situ and invasive neoplasm and increased in senescent cells
UniProtKB/Swiss-Prot Function:
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

Phenotypes From GWAS Catalog for IGFBP7 Gene

Gene Ontology (GO) - Molecular Function for IGFBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9388210
GO:0005520 insulin-like growth factor binding IEA --
GO:0019838 growth factor binding IEA --
genes like me logo Genes that share ontologies with IGFBP7: view
genes like me logo Genes that share phenotypes with IGFBP7: view

Human Phenotype Ontology for IGFBP7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IGFBP7 Gene

MGI Knock Outs for IGFBP7:

Animal Model Products

CRISPR Products

miRNA for IGFBP7 Gene

miRTarBase miRNAs that target IGFBP7

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for IGFBP7 (IGFBP-rp1/IGFBP-7)

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IGFBP7 Gene

Localization for IGFBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP7 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 2
golgi apparatus 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGFBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,TAS --
GO:0005615 extracellular space IDA 20551380
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with IGFBP7: view

Pathways & Interactions for IGFBP7 Gene

genes like me logo Genes that share pathways with IGFBP7: view

Pathways by source for IGFBP7 Gene

Gene Ontology (GO) - Biological Process for IGFBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007155 cell adhesion IEA,IDA 8117260
GO:0007566 embryo implantation IEA --
GO:0008285 negative regulation of cell proliferation TAS 8939990
GO:0009408 response to heat IEA --
genes like me logo Genes that share ontologies with IGFBP7: view

No data available for SIGNOR curated interactions for IGFBP7 Gene

Drugs & Compounds for IGFBP7 Gene

(5) Drugs for IGFBP7 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Insulin Human Approved, Investigational Pharma Target 0
Insulin Pork Approved Pharma Target 0

(6) Additional Compounds for IGFBP7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP7: view

Transcripts for IGFBP7 Gene

Unigene Clusters for IGFBP7 Gene

Insulin-like growth factor binding protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for IGFBP7 (IGFBP-rp1/IGFBP-7)

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - - - -
SP4: -

Relevant External Links for IGFBP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGFBP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFBP7 Gene

mRNA differential expression in normal tissues according to GTEx for IGFBP7 Gene

This gene is overexpressed in Artery - Aorta (x8.0), Artery - Coronary (x6.3), and Artery - Tibial (x5.7).

Protein differential expression in normal tissues from HIPED for IGFBP7 Gene

This gene is overexpressed in Amniocyte (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IGFBP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGFBP7 Gene:


SOURCE GeneReport for Unigene cluster for IGFBP7 Gene:


Evidence on tissue expression from TISSUES for IGFBP7 Gene

  • Nervous system(4.9)
  • Pancreas(4.4)
  • Intestine(3.8)
  • Eye(3.6)
  • Kidney(3.5)
  • Heart(3.1)
  • Lung(3)
  • Muscle(3)
  • Gall bladder(2.6)
  • Liver(2.6)
  • Skin(2.6)
  • Lymph node(2.4)
  • Adrenal gland(2.3)
  • Spleen(2.3)
  • Thyroid gland(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP7 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • nervous
  • respiratory
Head and neck:
  • ear
  • eye
  • head
  • heart
  • lung
  • blood
  • blood vessel
genes like me logo Genes that share expression patterns with IGFBP7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IGFBP7 Gene

Orthologs for IGFBP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGFBP7 33 34
  • 99.53 (n)
(Canis familiaris)
Mammalia IGFBP7 33 34
  • 95.2 (n)
(Bos Taurus)
Mammalia IGFBP7 33 34
  • 95.13 (n)
(Rattus norvegicus)
Mammalia Igfbp7 33
  • 91.57 (n)
(Mus musculus)
Mammalia Igfbp7 33 16 34
  • 91.04 (n)
(Monodelphis domestica)
Mammalia IGFBP7 34
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia IGFBP7 34
  • 83 (a)
(Gallus gallus)
Aves IGFBP7 33 34
  • 76.76 (n)
(Anolis carolinensis)
Reptilia IGFBP7 34
  • 82 (a)
(Danio rerio)
Actinopterygii igfbp7 33 34
  • 61.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for IGFBP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP7 Gene

Gene Tree for IGFBP7 (if available)
Gene Tree for IGFBP7 (if available)

Paralogs for IGFBP7 Gene

Paralogs for IGFBP7 Gene

(2) SIMAP similar genes for IGFBP7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGFBP7: view

Variants for IGFBP7 Gene

Sequence variations from dbSNP and Humsavar for IGFBP7 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs866994863 pathogenic, Retinal arterial macroaneurysm with supravascular pulmonic stenosis 57,031,337(-) C/T genic_downstream_transcript_variant, splice_acceptor_variant
rs1000095677 -- 57,105,530(-) T/C intron_variant
rs1000107071 -- 57,061,872(-) A/C intron_variant
rs1000107310 -- 57,064,831(-) T/C intron_variant
rs1000134709 -- 57,106,149(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IGFBP7 Gene

Variant ID Type Subtype PubMed ID
dgv1483e212 CNV loss 25503493
esv3569435 CNV loss 25503493
nsv1123797 CNV deletion 24896259

Variation tolerance for IGFBP7 Gene

Gene Damage Index Score: 3.91; 59.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFBP7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP7 Gene

Disorders for IGFBP7 Gene

MalaCards: The human disease database

(7) MalaCards diseases for IGFBP7 Gene - From: HGMD, OMIM, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinal arterial macroaneurysm with supravalvular pulmonic stenosis
  • ramsvps
diabetic angiopathy
  • diabetic vascular disorder
pulmonic stenosis
  • valvular pulmonic stenosis
late-onset retinal degenration
  • lord
uv-sensitive syndrome
  • uv sensitive syndrome
- elite association - COSMIC cancer census association via MalaCards


  • Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]: An autosomal recessive condition characterized by the bilateral appearance of beading along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. {ECO:0000269 PubMed:21835307}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for IGFBP7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IGFBP7: view

No data available for Genatlas for IGFBP7 Gene

Publications for IGFBP7 Gene

  1. Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells. (PMID: 7980422) Yamauchi T … Nawata H (The Biochemical journal 1994) 2 3 4 22 58
  2. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II. (PMID: 8939990) Oh Y … Rosenfeld RG (The Journal of biological chemistry 1996) 3 4 22 58
  3. Identification and characterization of genes differentially expressed in meningiomas. (PMID: 7694637) Murphy M … George DL (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993) 2 3 4 58
  4. Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms. (PMID: 21835307) Abu-Safieh L … Alkuraya FS (American journal of human genetics 2011) 3 4 58
  5. IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. (PMID: 19638426) Suzuki H … Toyota M (Carcinogenesis 2010) 3 22 58

Products for IGFBP7 Gene

Sources for IGFBP7 Gene

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