Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGFBP7 Gene

protein-coding   GIFtS: 65
GCID: GC04M057897

Insulin-Like Growth Factor Binding Protein 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin-Like Growth Factor Binding Protein 71 2     PGI2-Stimulating Factor2 3
MAC252 3 5     AGM2
Prostacyclin-Stimulating Factor2 3     FSTL22
Tumor-Derived Adhesion Factor2 3     IGFBP-7v2
IBP-72 3     IGFBPRP12
IGFBP-72 3     RAMSVPS2
IGFBP-rP12 3     angiomodulin2
PSF2 3     Insulin-Like Growth Factor-Binding Protein 72
TAF2 3     MAC25 Protein3
IGF-Binding Protein 72 3     

External Ids:    HGNC: 54761   Entrez Gene: 34902   Ensembl: ENSG000001634537   OMIM: 6028675   UniProtKB: Q162703   

Export aliases for IGFBP7 gene to outside databases

Previous GC identifers: GC04M057701 GC04M057893 GC04M057812 GC04M057738 GC04M057592 GC04M053850


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGFBP7 Gene:
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind
IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its
receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of
low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced
transcript variants encoding different isoforms have been described for this gene, and one variant has been
associated with retinal arterial macroaneurysm (PMID:21835307). (provided by RefSeq, Dec 2011)

GeneCards Summary for IGFBP7 Gene: 
IGFBP7 (insulin-like growth factor binding protein 7) is a protein-coding gene. Diseases associated with IGFBP7 include familial retinal arterial macroaneurysm, and diabetic angiopathy. GO annotations related to this gene include protein binding and insulin-like growth factor binding. An important paralog of this gene is KAZALD1.

UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270
Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production.
Stimulates cell adhesion

Gene Wiki entry for IGFBP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022853.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGFBP7 gene promoter:
         Spz1   Pax-5   AML1a   FOXF2   STAT5A   IRF-1   FOXO4   ATF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFBP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGFBP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

IGFBP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP7 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M057897:  view genomic region     (about GC identifiers)

Start:
57,896,939 bp from pter      End:
57,976,551 bp from pter
Size:
79,613 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 7 precursor  
Size: 282 amino acids; 29130 Da
Subunit: May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear
Subcellular location: Secreted
Rna editing: Modified_positions=78, 95; Note=Partially edited. In the brain, position 78 is edited at about 55%
and position 95 at about 31%
Secondary accessions: B4E1N2 B7Z9W7 Q07822 Q53YE6 Q9UCA8
Alternative splicing: 2 isoforms:  Q16270-1   Q16270-2   

Explore the universe of human proteins at neXtProt for IGFBP7: NX_Q16270

Explore proteomics data for IGFBP7 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16270

  • IGFBP7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGFBP7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001240764.1  NP_001544.1  

    ENSEMBL proteins: 
     ENSP00000295666   ENSP00000444146  

    Human Recombinant Protein Products for IGFBP7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IGFBP7 (IGFBP-rp1/IGFBP-7)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IGFBP7
    OriGene Protein Over-expression Lysate for IGFBP7
    OriGene MassSpec for IGFBP7 
    OriGene Custom Protein Services for IGFBP7
    GenScript Custom Purified and Recombinant Proteins Services for IGFBP7
    Novus Biologicals IGFBP7 Protein
    Novus Biologicals IGFBP7 Lysate
    Sino Biological Recombinant Protein for IGFBP7
    Sino Biological Cell Lysate for IGFBP7 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IGFBP7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA--
    GO:0031012colocalizes with extracellular matrix IDA--

    IGFBP7 for ontologies           About GeneDecksing



    IGFBP7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IGFBP7 (IGFBP-rp1/IGFBP-7)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IGFBP7
    GenScript Custom Superior Antibodies Services for IGFBP7
    Novus Biologicals IGFBP7 Antibodies
    Abcam antibodies for IGFBP7
    Cloud-Clone Corp. Antibodies for IGFBP7 
    ThermoFisher Antibodies for IGFBP7
    LSBio Antibodies in human, mouse, rat for IGFBP7 

    Assay Products for IGFBP7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IGFBP7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IGFBP7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IGFBP7 
    Cloud-Clone Corp. CLIAs for IGFBP7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR002350 Kazal_dom
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR011390 IGFBP_rP_mac25
     IPR000867 IGFBP-like

    Graphical View of Domain Structure for InterPro Entry Q16270

    ProtoNet protein and cluster: Q16270

    3 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB011497 Protease inhibitor
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 Kazal-like domain


    IGFBP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBP7_HUMAN, Q16270
    Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production.
    Stimulates cell adhesion

         Genatlas biochemistry entry for IGFBP7:
    insuline-like growth factor binding protein 7 (related protein 1),expressed in both in situ and invasive neoplasm
    and increased in senescent cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI9388210
    GO:0005520insulin-like growth factor binding IEA--
         
    IGFBP7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IGFBP7:
     Enable proliferation in B-Raf   Low eccentricity cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Igfbp7):
     no phenotypic analysis 

    IGFBP7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGFBP7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGFBP7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGFBP7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGFBP7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBP7
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP7:
    hsa-miR-3674 hsa-miR-3935
    SwitchGear 3'UTR luciferase reporter plasmidIGFBP7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IGFBP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBP7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IGFBP7
    Sirion Biotech Customized adenovirus for overexpression of IGFBP7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IGFBP7 (see all 8)
    OriGene ORF clones in mouse, rat for IGFBP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IGFBP7 (NM_001553)
    Sino Biological Human cDNA Clone for IGFBP7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP7
    Sirion Biotech Customized lentivirus for stable overexpression of IGFBP7 
                         Customized lentivirus expression plasmids for stable overexpression of IGFBP7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IGFBP7
    LifeMap BioReagents: cell line associated with IGFBP7: PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGFBP7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy


    1 BioSystems Pathway for IGFBP7
        Senescence and Autophagy



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGFBP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/18 Interacting proteins for IGFBP7 (Q162702, 3 ENSP000002956664) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGF1P050193, ENSP000003026654I2D: score=3 STRING: ENSP00000302665
    IGF2P013443, ENSP000003382974I2D: score=2 STRING: ENSP00000338297
    JUNP054123, ENSP000003602664I2D: score=1 STRING: ENSP00000360266
    CHMP3Q9Y3E73, ENSP000002638564I2D: score=2 STRING: ENSP00000263856
    INHBAP084763, ENSP000002422084I2D: score=1 STRING: ENSP00000242208
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0007155cell adhesion IDA8117260
    GO:0008285negative regulation of cell proliferation TAS8939990
    GO:0009451RNA modification IEA--
    GO:0048839inner ear development IEA--

    IGFBP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGFBP7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGFBP7 (IBP7)

    2 DrugBank Compounds for IGFBP7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Insulin, porcine-- 9004-14-2target--11089538 17475416 17016423 10383131 17139284
    Insulin Regular -- 11061-68-0target--17139284 17016423

    9 Novoseek inferred chemical compound relationships for IGFBP7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 66.9 3 19094461 (1), 17236181 (1), 19638426 (1)
    prostacyclin 63.4 25 8435236 (3), 7980422 (3), 1837513 (3), 8982858 (2) (see all 12)
    agar 35 2 10344746 (1), 17465992 (1)
    txb2 20.9 1 1837513 (1)
    retinoic acid 19 9 7538673 (2), 11295114 (1), 11089538 (1)
    vegf 4.13 2 19374835 (2)
    serine 4.03 1 16420484 (1)
    glucose 0 10 15027891 (3), 9313760 (3), 16873698 (1)
    estrogen 0 5 17545519 (1), 11429696 (1)

    Search CenterWatch for drugs/clinical trials and news about IGFBP7 / IBP7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IGFBP7 gene (2 alternative transcripts): 
    NM_001253835.1  NM_001553.2  

    Unigene Clusters for IGFBP7:

    Insulin-like growth factor binding protein 7
    Hs.479808  [show with all ESTs], Hs.691061  [show with all ESTs]
    Unigene Representative Sequences: BX648756, NR_034081
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512512 ENST00000295666(uc003hcn.3) ENST00000514062 ENST00000537922(uc011cag.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBP7
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP7:
    hsa-miR-3674 hsa-miR-3935
    SwitchGear 3'UTR luciferase reporter plasmidIGFBP7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IGFBP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBP7
    Clone
    Products:
         
    OriGene clones in human, mouse for IGFBP7 (see all 8)
    OriGene ORF clones in mouse, rat for IGFBP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IGFBP7 (NM_001553)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP7
    Sirion Biotech Customized lentivirus for stable overexpression of IGFBP7 
                         Customized lentivirus expression plasmids for stable overexpression of IGFBP7 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IGFBP7
    OriGene qSTAR qPCR primer pairs in human, mouse for IGFBP7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IGFBP7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBP7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP7

    Additional mRNA sequence: 

    AF540057.1 BC039519.1 NR_034081.1 

    24/34 DOTS entries (see all 34):

    DT.95170564  DT.92040454  DT.97760173  DT.40205446  DT.100045783  DT.95170547  DT.95170563  DT.100674865 
    DT.91955903  DT.99998233  DT.100674866  DT.121637242  DT.451262  DT.92413462  DT.95170568  DT.100674872 
    DT.121219229  DT.401514  DT.65285131  DT.95104371  DT.121219201  DT.121219282  DT.121219324  DT.121219395 

    24/688 AceView cDNA sequences (see all 688):

    BF939862 AI753930 BU688318 AI138712 CR607474 T29853 BM887781 CD679004 
    AW276585 BM023078 AI923605 AI354240 T60179 AW130145 BF725225 CD558829 
    AI085399 AA550957 AI832779 AW276628 CR626227 CA942900 BU679023 BM129113 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP7    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:                                            -     -               
    SP2:                    -     -                 -     -               
    SP3:                                                                  
    SP4:                    -                                             


    ECgene alternative splicing isoforms for IGFBP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGFBP7 expression in normal human tissues (normalized intensities)      IGFBP7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATATCATTA
    IGFBP7 Expression
    About this image


    IGFBP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Intervertebral Disc Annulus Fibrosus Cells Thoracic Intervertebral Disc
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Pre-Sertoli Cells Testis Cord
             Seminiferous Tubules
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Mature Cardiac Fibroblasts Myocardium
             Coronary Artery Smooth Muscle Cells (CASMC)   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             visceral organ/urogenital sinus/primitive bladder   
     
     Smooth Muscle (Muscoskeletal System)
             Coronary Artery Smooth Muscle Cells (CASMC)   

    See IGFBP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGFBP7

    SOURCE GeneReport for Unigene clusters: Hs.479808 Hs.691061
        SABiosciences Expression via Pathway-Focused PCR Arrays including IGFBP7: 
              Cancer PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IGFBP7
    OriGene qSTAR qPCR primer pairs in human, mouse for IGFBP7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IGFBP7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBP7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP7 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfbp71 , 5 insulin-like growth factor binding protein 71, 5 91.1(n)1
    91.46(a)1
      5 (41.71 cM)5
    298171  NM_008048.31  NP_032074.31 
     773492405 
    chicken
    (Gallus gallus)
    Aves IGFBP71 insulin-like growth factor binding protein 7 74.41(n)
    75.66(a)
      422620  XM_420577.3  XP_420577.3 
    lizard
    (Anolis carolinensis)
    Reptilia IGFBP76
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL343257.1(1872867-1880497)
    zebrafish
    (Danio rerio)
    Actinopterygii igfbp71 insulin-like growth factor binding protein 7 59.52(n)
    56.35(a)
      405860  NM_212924.2  NP_998089.1 


    ENSEMBL Gene Tree for IGFBP7 (if available)
    TreeFam Gene Tree for IGFBP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGFBP7 gene
    KAZALD12  IGFBPL12  
    2 SIMAP similar genes for IGFBP7 using alignment to 1 protein entry:     IBP7_HUMAN:
    IGFBPL1    KAZALD1

    IGFBP7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1903 SNPs in IGFBP7 are shown (see all 1903)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0636394
    ----see VAR_0636392 K R mis40--------
    VAR_0636384
    ----see VAR_0636382 R G mis40--------
    rs1888421921,2
    --53853801(+) AAAAAA/CAAAAA 2 -- int10--------
    rs2016293931,2
    C--53859736(-) AAAAAA/GAAAAA 2 -- int10--------
    rs105930931,2
    C--53874110(+) GAATT-/AA    
       
    /CTAA
    GCAAT
    2 -- int11NA 2
    rs114517681,2
    C--53888813(+) ACCCA-/GC    
       CAT
    /T
    TAAGC
    2 -- int10--------
    rs106599601,2
    C--53892423(+) GCCTATAAA    
       GGT
    /-
    GCCAC
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs720115101,2
    C--53892424(+) CCTAG-/TA    
       AAGGT
    CCACC
    2 -- int10--------
    rs113386721,2
    C,F--53895215(+) CCCCTG/-CAGGA 2 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1415405301,2
    C--53895215(+) CCCCTC/G/TCAGGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for IGFBP7 (57896939 - 57976551 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IGFBP7: --

    Human Gene Mutation Database (HGMD): IGFBP7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IGFBP7
    DNA2.0 Custom Variant and Variant Library Synthesis for IGFBP7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602867    OMIM disorders: --

    UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270
  • Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]: An autosomal
    recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial
    trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic
    stenosis, often requiring surgical correction. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 20/45 diseases for IGFBP7 (see all 45):    About MalaCards
    familial retinal arterial macroaneurysm    diabetic angiopathy    pulmonic stenosis    cerebral aneurysms
    ring chromosomes    bladder carcinoma    ductal carcinoma in situ    meningioma
    teratocarcinoma    retinitis    non-small cell lung carcinoma    thrombosis
    vascular disease    insulin resistance    age related macular degeneration    colorectal cancer
    colon cancer    acute leukemia    endometriosis    osteoarthritis


    IGFBP7 for disorders           About GeneDecksing

    10/24 Novoseek inferred disease relationships for IGFBP7 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetic angiopathies 56.9 2 8674874 (2)
    bladder carcinoma 36.7 2 17465992 (1), 14521955 (1)
    tumors 32.3 45 17136345 (4), 11429696 (4), 10344746 (2), 18701096 (2) (see all 21)
    colon cancer 29.8 5 18981723 (1), 17334979 (1), 17465992 (1), 9605951 (1)
    colorectal cancer 29.4 14 19094461 (6), 18701096 (3), 15027891 (2), 17136345 (1) (see all 5)
    prostate cancer 28.5 22 14633696 (6), 10344746 (3), 10383131 (3), 9851777 (1) (see all 7)
    benign prostatic hyperplasia 21.4 1 14633696 (1)
    breast cancer 19.3 12 17634530 (4), 15979304 (2), 11295114 (1), 9449045 (1) (see all 7)
    cancer 16.8 13 15027891 (4), 8939990 (1), 11295114 (1), 11400113 (1) (see all 8)
    meningioma 11 2 11089538 (1), 7538673 (1)

    Genetic Association Database (GAD): IGFBP7
    Human Genome Epidemiology (HuGE) Navigator: IGFBP7 (3 documents)

    Export disorders for IGFBP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGFBP7 gene, integrated from 9 sources (see all 156):
    (articles sorted by number of sources associating them with IGFBP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells. (PubMed id 7980422)1, 2, 3, 9 Yamauchi T....Nawata H. (1994)
    2. Identification and characterization of genes differentially expressed in meningiomas. (PubMed id 7694637)1, 2, 3 Murphy M.... George D.L. (1993)
    3. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II. (PubMed id 8939990)1, 2, 9 Oh Y....Rosenfeld R.G. (1996)
    4. Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms. (PubMed id 21835307)1, 2 Abu-Safieh L.... Alkuraya F.S. (2011)
    5. The functional IGFBP7 promoter -418G>A polymorphis m and risk of head and neck cancer. (PubMed id 20599521)1, 4 Huang Y.J....Wei Q. (2010)
    6. Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PubMed id 15708897)1, 4 Kawahara C....Loughlin J. (2005)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells. (PubMed id 11549700)1, 2 Wilson E.M.... Rosenfeld R.G. (2001)
    10. Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells. (PubMed id 8117260)1, 2 Akaogi K.... Miyazaki K. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3490 HGNC: 5476 AceView: IGFBP7 Ensembl:ENSG00000163453 euGenes: HUgn3490
    ECgene: IGFBP7 H-InvDB: IGFBP7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGFBP7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGFBP7 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGFBP7 gene:
    Search GeneIP for patents involving IGFBP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for IGFBP7 (IGFBP-rp1/IGFBP-7)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for IGFBP7 (IGFBP-rp1/IGFBP-7)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IGFBP7  
     OriGene qPCR primer pairs and template standards for IGFBP7   OriGene Protein Over-expression Lysate for IGFBP7  
     OriGene MassSpec something-or-other for IGFBP7   OriGene clones in human, mouse for IGFBP7  
     OriGene qSTAR qPCR primer pairs in human, mouse for IGFBP7   OriGene Purified Protein for IGFBP7  
     OriGene ORF clones in mouse, rat for IGFBP7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IGFBP7   OriGene Custom Protein Services for IGFBP7  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGFBP7
     QIAGEN SeqTarget long-range PCR primers for resequencing IGFBP7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBP7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBP7
     GenScript Custom Purified and Recombinant Proteins Services for IGFBP7 GenScript cDNA clones with any tag delivered in your preferred vector for IGFBP7
     GenScript Custom Assay Services for IGFBP7 GenScript Custom Superior Antibodies Services for IGFBP7
     GenScript Custom overexpressing Cell Line Services for IGFBP7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IGFBP7 promoter
     Search Chromatin IP Primers for IGFBP7
     RT2 qPCR Primer Assay in human, mouse, rat IGFBP7
     GNC Network for IGFBP7
     SABiosciences PCR Arrays including human, mouse, rat IGFBP7
     Search Tocris compounds for IGFBP7 (IBP7)
     Proteins and Antibodies for IGFBP7
     Cell Lysates for IGFBP7
     cDNA Clones for IGFBP7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IGFBP7 antibodies
     IGFBP7 proteins
     IGFBP7 lysates
     Antibodies for IGFBP7
     See all of Abcam's Antibodies, Kits and Proteins for IGFBP7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for IGFBP7
     Antibodies for IGFBP7
     ELISAs for IGFBP7
     CLIAs for IGFBP7
     Cell Line associated with IGFBP7: PureStem ES-210, Ecto-ntu Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP7
     SwitchGear 3'UTR luciferase reporter plasmids for IGFBP7
     SwitchGear Promoter luciferase reporter plasmids for IGFBP7
     ThermoFisher Antibodies for IGFBP7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP7
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IGFBP7
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGFBP7
    Customized:
     lentivirus for stable overexpression of IGFBP7
     lentivirus expression plasmids for stable overexpression of IGFBP7
     adenovirus for overexpression of IGFBP7
     LSBio Antibodies in human, mouse, rat for IGFBP7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IGFBP7 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4