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Aliases for IGFBP7 Gene

Aliases for IGFBP7 Gene

  • Insulin Like Growth Factor Binding Protein 7 2 3 5
  • Insulin-Like Growth Factor Binding Protein 7 2 3
  • Prostacyclin-Stimulating Factor 3 4
  • Tumor-Derived Adhesion Factor 3 4
  • PGI2-Stimulating Factor 3 4
  • IGF-Binding Protein 7 3 4
  • IGFBP-RP1 3 4
  • IGFBP-7 3 4
  • IBP-7 3 4
  • MAC25 3 4
  • PSF 3 4
  • TAF 3 4
  • MAC25 Protein 4
  • Angiomodulin 3
  • IGFBP-7v 3
  • IGFBPRP1 3
  • RAMSVPS 3
  • FSTL2 3
  • AGM 3

External Ids for IGFBP7 Gene

Previous GeneCards Identifiers for IGFBP7 Gene

  • GC04M057701
  • GC04M057893
  • GC04M057812
  • GC04M057738
  • GC04M057592
  • GC04M053850
  • GC04M057897

Summaries for IGFBP7 Gene

Entrez Gene Summary for IGFBP7 Gene

  • This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

GeneCards Summary for IGFBP7 Gene

IGFBP7 (Insulin Like Growth Factor Binding Protein 7) is a Protein Coding gene. Diseases associated with IGFBP7 include retinal arterial macroaneurysm with supravalvular pulmonic stenosis and diabetic angiopathy. Among its related pathways are Cellular Senescence and Senescence and Autophagy. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is KAZALD1.

UniProtKB/Swiss-Prot for IGFBP7 Gene

  • Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

Gene Wiki entry for IGFBP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP7 Gene

Genomics for IGFBP7 Gene

Regulatory Elements for IGFBP7 Gene

Promoters for IGFBP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IGFBP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGFBP7 Gene

Chromosome:
4
Start:
57,030,773 bp from pter
End:
57,110,385 bp from pter
Size:
79,613 bases
Orientation:
Minus strand

Genomic View for IGFBP7 Gene

Genes around IGFBP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP7 Gene

Proteins for IGFBP7 Gene

  • Protein details for IGFBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16270-IBP7_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 7
    Protein Accession:
    Q16270
    Secondary Accessions:
    • B4E1N2
    • B7Z9W7
    • Q07822
    • Q53YE6
    • Q9UCA8

    Protein attributes for IGFBP7 Gene

    Size:
    282 amino acids
    Molecular mass:
    29130 Da
    Quaternary structure:
    • May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.

    Alternative splice isoforms for IGFBP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFBP7 Gene

Proteomics data for IGFBP7 Gene at MOPED

Post-translational modifications for IGFBP7 Gene

Other Protein References for IGFBP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IGFBP7 (IGFBP-rp1/IGFBP-7)

No data available for DME Specific Peptides for IGFBP7 Gene

Domains & Families for IGFBP7 Gene

Gene Families for IGFBP7 Gene

Suggested Antigen Peptide Sequences for IGFBP7 Gene

Graphical View of Domain Structure for InterPro Entry

Q16270

UniProtKB/Swiss-Prot:

IBP7_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with IGFBP7: view

Function for IGFBP7 Gene

Molecular function for IGFBP7 Gene

GENATLAS Biochemistry:
insuline-like growth factor binding protein 7 (related protein 1),expressed in both in situ and invasive neoplasm and increased in senescent cells
UniProtKB/Swiss-Prot Function:
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
genes like me logo Genes that share phenotypes with IGFBP7: view

Human Phenotype Ontology for IGFBP7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IGFBP7 Gene

MGI Knock Outs for IGFBP7:

Animal Model Products

miRNA for IGFBP7 Gene

miRTarBase miRNAs that target IGFBP7

Inhibitory RNA Products

Cell Line Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for IGFBP7 Gene

Localization for IGFBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFBP7 Gene COMPARTMENTS Subcellular localization image for IGFBP7 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
plasma membrane 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGFBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with IGFBP7: view

Pathways & Interactions for IGFBP7 Gene

genes like me logo Genes that share pathways with IGFBP7: view

Pathways by source for IGFBP7 Gene

Gene Ontology (GO) - Biological Process for IGFBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 8939990
genes like me logo Genes that share ontologies with IGFBP7: view

No data available for SIGNOR curated interactions for IGFBP7 Gene

Drugs & Compounds for IGFBP7 Gene

(4) Drugs for IGFBP7 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Insulin Regular Approved, Experimental, Investigational Pharma Target 0
Insulin, porcine Approved Pharma Target 0

(7) Additional Compounds for IGFBP7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP7: view

Transcripts for IGFBP7 Gene

mRNA/cDNA for IGFBP7 Gene

Unigene Clusters for IGFBP7 Gene

Insulin-like growth factor binding protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - - - -
SP3:
SP4: -

Relevant External Links for IGFBP7 Gene

GeneLoc Exon Structure for
IGFBP7
ECgene alternative splicing isoforms for
IGFBP7

Expression for IGFBP7 Gene

mRNA expression in normal human tissues for IGFBP7 Gene

mRNA differential expression in normal tissues according to GTEx for IGFBP7 Gene

This gene is overexpressed in Artery - Aorta (x8.0), Artery - Coronary (x6.3), and Artery - Tibial (x5.7).

Protein differential expression in normal tissues from HIPED for IGFBP7 Gene

This gene is overexpressed in Amniocyte (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGFBP7 Gene



SOURCE GeneReport for Unigene cluster for IGFBP7 Gene Hs.479808

genes like me logo Genes that share expression patterns with IGFBP7: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IGFBP7 Gene

Orthologs for IGFBP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBP7 35
  • 99.53 (n)
  • 100 (a)
IGFBP7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGFBP7 36
  • 96 (a)
OneToOne
IGFBP7 35
  • 95.13 (n)
  • 95.65 (a)
dog
(Canis familiaris)
Mammalia IGFBP7 35
  • 95.2 (n)
  • 95.34 (a)
IGFBP7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igfbp7 16
Igfbp7 35
  • 91.04 (n)
  • 90.91 (a)
Igfbp7 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFBP7 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP7 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igfbp7 35
  • 91.57 (n)
  • 90.51 (a)
chicken
(Gallus gallus)
Aves IGFBP7 35
  • 76.76 (n)
  • 78.49 (a)
IGFBP7 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGFBP7 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii igfbp7 36
  • 54 (a)
OneToOne
igfbp7 35
  • 61.02 (n)
  • 58.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for IGFBP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP7 Gene

ENSEMBL:
Gene Tree for IGFBP7 (if available)
TreeFam:
Gene Tree for IGFBP7 (if available)

Paralogs for IGFBP7 Gene

Paralogs for IGFBP7 Gene

(2) SIMAP similar genes for IGFBP7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGFBP7: view

Variants for IGFBP7 Gene

Sequence variations from dbSNP and Humsavar for IGFBP7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_018959 -
VAR_063638 -
VAR_063639 -
rs1111626 -- 57,087,074(+) GAGAC(C/G)GACAC intron-variant
rs881382 -- 57,051,180(-) TCATC(A/C)CCTTC intron-variant

Variation tolerance for IGFBP7 Gene

Gene Damage Index Score: 3.91; 59.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFBP7 Gene

HapMap Linkage Disequilibrium report
IGFBP7
Human Gene Mutation Database (HGMD)
IGFBP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGFBP7 Gene

Disorders for IGFBP7 Gene

MalaCards: The human disease database

(7) MalaCards diseases for IGFBP7 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinal arterial macroaneurysm with supravalvular pulmonic stenosis
  • familial retinal arterial macroaneurysm
diabetic angiopathy
  • diabetic vascular disorder
pulmonic stenosis
  • pulmonary valve stenosis
uv-sensitive syndrome
  • uv sensitive syndrome
cerebral aneurysms
  • cerebral aneurysm
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

IBP7_HUMAN
  • Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]: An autosomal recessive condition characterized by the bilateral appearance of beading along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. {ECO:0000269 PubMed:21835307}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IGFBP7

Genetic Association Database (GAD)
IGFBP7
Human Genome Epidemiology (HuGE) Navigator
IGFBP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFBP7
genes like me logo Genes that share disorders with IGFBP7: view

No data available for Genatlas for IGFBP7 Gene

Publications for IGFBP7 Gene

  1. Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells. (PMID: 7980422) Yamauchi T. … Nawata H. (Biochem. J. 1994) 2 3 4 23 67
  2. Insulin-like growth factor-binding protein 7 regulates keratinocyte proliferation, differentiation and apoptosis. (PMID: 19710688) Nousbeck J. … Sprecher E. (J. Invest. Dermatol. 2010) 3 23
  3. Knockdown of IGF-binding protein 7 inhibits transformation of the endometrial gland in an in vitro model. (PMID: 20029996) Kutsukake M. … Tachikawa E. (Mol. Reprod. Dev. 2010) 3 23
  4. Insulin-like growth factor-binding protein 7 alters the sensitivity to interferon-based anticancer therapy in hepatocellular carcinoma cells. (PMID: 20407444) Tomimaru Y. … Nagano H. (Br. J. Cancer 2010) 3 23
  5. IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. (PMID: 19638426) Suzuki H. … Toyota M. (Carcinogenesis 2010) 3 23

Products for IGFBP7 Gene

Sources for IGFBP7 Gene

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