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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGFBP7 Gene

protein-coding   GIFtS: 62
GCID: GC04M057897

insulin-like growth factor binding protein 7
 Explore 41 diseases affiliated with
IGFBP7 via
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 Human Malady Compendium 
Biological research products
for IGFBP7    

Aliases
for IGFBP7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Insulin-Like Growth Factor Binding Protein 71 2     IGF-Binding Protein 72 3
MAC251 2 3 5     PGI2-Stimulating Factor2 3
IGFBP-71 2 3     AGM2
PSF1 2 3     IGFBP-7v2
FSTL21 2     IGFBPRP12
Prostacyclin-Stimulating Factor2 3     RAMSVPS2
Tumor-Derived Adhesion Factor2 3     Angiomodulin1
IBP-72 3     Insulin-Like Growth Factor-Binding Protein 72
IGFBP-RP11     MAC25 Protein3
TAF2 3     

External Ids:    HGNC: 54761   Entrez Gene: 34902   Ensembl: ENSG000001634537   OMIM: 6028675   UniProtKB: Q162703   

Export aliases for IGFBP7 gene to outside databases

Previous GC identifers: GC04M057701 GC04M057893 GC04M057812 GC04M057738 GC04M057592 GC04M053850


Summaries
for IGFBP7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IGFBP7:
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs
with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its
receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of
low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript
variants encoding different isoforms have been described for this gene, and one variant has been associated with
retinal arterial macroaneurysm (PMID:21835307). (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270
Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates
cell adhesion

Gene Wiki entry for IGFBP7


Genomic Views
for IGFBP7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022853.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGFBP7 gene promoter:
         Spz1   Pax-5   AML1a   FOXF2   STAT5A   IRF-1   FOXO4   ATF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGFBP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGFBP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

IGFBP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP7 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M057897:  view genomic region     (about GC identifiers)

Start:
 57,896,939 bp from pter      End:
 57,976,551 bp from pter
Size:
 79,613 bases      Orientation:
 minus strand

Proteins
for IGFBP7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 7 precursor  
Size: 282 amino acids; 29130 Da
Subunit: May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear
Subcellular location: Secreted
Rna editing: Modified_positions=78, 95; Note=Partially edited. In the brain, position 78 is edited at about 55% and
position 95 at about 31%
Secondary accessions: B4E1N2 B7Z9W7 Q07822 Q53YE6 Q9UCA8
Alternative splicing: 2 isoforms:  Q16270-1   Q16270-2   

Explore the universe of human proteins at neXtProt for IGFBP7: NX_Q16270

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16270

    • IGFBP7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001240764.1  NP_001544.1  

    ENSEMBL proteins: 
     ENSP00000295666   ENSP00000444146  

    Human Recombinant Protein Products: 
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    Uscn Proteins for IGFBP7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA--
    GO:0031012colocalizes with extracellular matrix IDA--


    IGFBP7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for IGFBP7

    Protein Domains /
    Families
    for IGFBP7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGFBP7 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR002350 Prot_inh_Kazal
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR011390 IGFBP_rP_mac25
     IPR000867 IGFBP-like

    Graphical View of Domain Structure for InterPro Entry Q16270

    ProtoNet protein and cluster: Q16270

    3 Blocks protein families:
    IPB003599 Immunoglobulin subtype
    IPB011497 Protease inhibitor
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 Kazal-like domain


    Function
    for IGFBP7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270
    Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates
    cell adhesion

         Genatlas biochemistry entry for IGFBP7:
    insuline-like growth factor binding protein 7 (related protein 1),expressed in both in situ and invasive neoplasm and
    increased in senescent cells

    miRNA
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    hsa-miR-3674 hsa-miR-3935
    SwitchGear 3'UTR luciferase reporter plasmid: IGFBP7 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    LifeMap BioReagents: cell line associated with IGFBP7: PureStem ES-210, Ecto-ntu Progenitor

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGFBP7

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI9388210
    GO:0005520insulin-like growth factor binding IEA--


    IGFBP7 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for IGFBP7:
     Enable proliferation in B-Raf   Low eccentricity cells 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Igfbp7):
     no phenotypic analysis 

    IGFBP7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IGFBP7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Senescence and Autophagy
    		Senescence and Autophagy1.00


    1 BioSystems Pathway for IGFBP7 
        Senescence and Autophagy


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGFBP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/18 Interacting proteins for IGFBP7 (Q162702, 3 ENSP000002956664) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGF1P050193, ENSP000003026654I2D: score=3 STRING: ENSP00000302665
    IGF2P013443, ENSP000003382974I2D: score=2 STRING: ENSP00000338297
    JUNP054123, ENSP000003602664I2D: score=1 STRING: ENSP00000360266
    CHMP3Q9Y3E73, ENSP000002638564I2D: score=2 STRING: ENSP00000263856
    INHBAP084763, ENSP000002422084I2D: score=1 STRING: ENSP00000242208
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0007155cell adhesion IDA8117260
    GO:0008285negative regulation of cell proliferation TAS8939990
    GO:0048839inner ear development IEA--


    IGFBP7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IGFBP7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGFBP7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGFBP7

    2 DrugBank Compounds for IGFBP7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Insulin, porcine-- 9004-14-2target--11089538 17475416 17016423 10383131 17139284
    Insulin recombinant-- 9004-10-8target--17139284 17016423

    9 Novoseek chemical compound relationships for IGFBP7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 66.9 3 19094461 (1), 17236181 (1), 19638426 (1)
    prostacyclin 63.4 25 8435236 (3), 7980422 (3), 1837513 (3), 8982858 (2) (see all 12)
    agar 35 2 10344746 (1), 17465992 (1)
    txb2 20.9 1 1837513 (1)
    retinoic acid 19 9 7538673 (2), 11295114 (1), 11089538 (1)
    vegf 4.13 2 19374835 (2)
    serine 4.03 1 16420484 (1)
    glucose 0 10 15027891 (3), 9313760 (3), 16873698 (1)
    estrogen 0 5 17545519 (1), 11429696 (1)

    Search CenterWatch for drugs/clinical trials and news about IGFBP7 / IBP7 

    Transcripts
    for IGFBP7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IGFBP7 gene (2 alternative transcripts): 
    NM_001253835.1  NM_001553.2  

    Unigene Clusters for IGFBP7:

    Insulin-like growth factor binding protein 7
    Hs.479808  [show with all ESTs], Hs.691061  [show with all ESTs]
    Unigene Representative Sequences: BX648756, NR_034081
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295666(uc003hcn.3) ENST00000537922(uc011cag.2)

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP7:
    hsa-miR-3674 hsa-miR-3935
    SwitchGear 3'UTR luciferase reporter plasmid: IGFBP7 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: IGFBP7 (NM_001553)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP7

    Additional cDNA sequence: 

    AF540057.1 BC039519.1 NR_034081.1 

    24/34 DOTS entries (see all 34):

    DT.95170564  DT.92040454  DT.97760173  DT.40205446  DT.100045783  DT.95170547  DT.95170563  DT.100674865 
    DT.91955903  DT.99998233  DT.100674866  DT.121637242  DT.451262  DT.92413462  DT.95170568  DT.100674872 
    DT.121219229  DT.401514  DT.65285131  DT.95104371  DT.121219201  DT.121219282  DT.121219324  DT.121219395 

    24/688 AceView cDNA sequences (see all 688):

    CA414974 BM955746 CD558829 AA214145 BM928178 AI346794 BM673661 CD517905 
    NM_001553 AI138712 AA627724 AW069212 BG109612 CD673426 BU734259 CD677879 
    CA438170 CR626227 AW192242 AI923605 BE612824 BF056097 BM023078 BQ477415 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP7    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:                                            -     -               
    SP2:                    -     -                 -     -               
    SP3:                                                                  
    SP4:                    -                                             


    ECgene alternative splicing isoforms for IGFBP7

    Expression
    for IGFBP7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGFBP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATATCATTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IGFBP7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    AdiposeVisceral White AdiposeVisceral White PreadipocytesAdipose
    EyeInner Nuclear LayerCholinergic Amacrine CellsAmacrine, Retina
    CartilageLumbar Intervertebral DiscCartilage
    Intermediate MesodermIntermediate MesodermIntermediate Mesoderm
    Reproductive SystemMesonephrosReproductive System
    TestisSeminiferous TubulesTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium

    See IGFBP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGFBP7

    SOURCE GeneReport for Unigene clusters: Hs.479808 Hs.691061
        SABiosciences Expression via Pathway-Focused PCR Arrays including IGFBP7: 
              Cancer PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for IGFBP7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP7 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IGFBP71 insulin-like growth factor binding protein 7 74.41(n)
    75.66(a)    		   422620  XM_420577.3  XP_420577.3 
    lizard
    (Anolis carolinensis)    		 Reptilia IGFBP76
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343257.1(1872867-1880494)
    zebrafish
    (Danio rerio)    		 Actinopterygii igfbp71 insulin-like growth factor binding protein 7 59.52(n)
    56.35(a)    		   405860  NM_212924.2  NP_998089.1 


    ENSEMBL Gene Tree for IGFBP7 (if available)
    TreeFam Gene Tree for IGFBP7 (if available) 

    Paralogs
    for IGFBP7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGFBP7 gene
    KAZALD12  IGFBPL12  
    2 SIMAP similar genes for IGFBP7 using alignment to 1 protein entry:     IBP7_HUMAN:
    IGFBPL1    KAZALD1

    IGFBP7 for paralogs           About GeneDecksing



    Genomic Variants
    for IGFBP7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): IGFBP7
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFBP7
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    Disorders / Diseases
    for IGFBP7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGFBP7 for disorders           About GeneDecksing

    OMIM gene information: 602867    OMIM disorders: --

    UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270
  • Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis
    • (RAMSVPS) [MIM:614224]. RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of
    'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected
    individuals also have supravalvular pulmonic stenosis, often requiring surgical correction

    20/41 diseases for IGFBP7 (see all 41):    About MalaCards
    non-small cell lung carcinoma    pulmonic stenosis    retinitis    diabetic angiopathy
    ring chromosomes    urinary bladder cancer    insulin resistance    diabetes mellitus
    ductal carcinoma in situ    acute lymphoblastic leukemia    lymphoblastic leukemia    acute myeloid leukemia
    bladder carcinoma    myeloid leukemia    cerebral aneurysms    thrombosis
    carcinoma    colon cancer    teratocarcinoma    lung carcinoma

    10/24 Novoseek disease relationships for IGFBP7 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetic angiopathies 56.9 2 8674874 (2)
    bladder carcinoma 36.7 2 17465992 (1), 14521955 (1)
    tumors 32.3 45 17136345 (4), 11429696 (4), 10344746 (2), 18701096 (2) (see all 21)
    colon cancer 29.8 5 18981723 (1), 17334979 (1), 17465992 (1), 9605951 (1)
    colorectal cancer 29.4 14 19094461 (6), 18701096 (3), 15027891 (2), 17136345 (1) (see all 5)
    prostate cancer 28.5 22 14633696 (6), 10344746 (3), 10383131 (3), 9851777 (1) (see all 7)
    benign prostatic hyperplasia 21.4 1 14633696 (1)
    breast cancer 19.3 12 17634530 (4), 15979304 (2), 11295114 (1), 9449045 (1) (see all 7)
    cancer 16.8 13 15027891 (4), 8939990 (1), 11295114 (1), 11400113 (1) (see all 8)
    meningioma 11 2 11089538 (1), 7538673 (1)

    Genetic Association Database (GAD): IGFBP7
    Human Genome Epidemiology (HuGE) Navigator: IGFBP7 (3 documents)

    Export disorders for IGFBP7 gene to outside databases

    Publications
    for IGFBP7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGFBP7 gene, integrated from 9 sources (see all 146):
    (articles sorted by number of sources associating them with IGFBP7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells. (PubMed id 7980422)1, 2, 3, 9 Yamauchi T....Nawata H. (1994)
    2. Identification and characterization of genes differentially expressed in meningiomas. (PubMed id 7694637)1, 2, 3 Murphy M.... George D.L. (1993)
    3. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II. (PubMed id 8939990)1, 2, 9 Oh Y....Rosenfeld R.G. (1996)
    4. Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms. (PubMed id 21835307)1, 2 Abu-Safieh L.... Alkuraya F.S. (2011)
    5. Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PubMed id 15708897)1, 4 Kawahara C....Loughlin J. (2005)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells. (PubMed id 11549700)1, 2 Wilson E.M.... Rosenfeld R.G. (2001)
    9. Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells. (PubMed id 8117260)1, 2 Akaogi K.... Miyazaki K. (1994)
    10. Circulating IGF-binding protein 7 (IGFBP7) levels are elevated in patients with endometriosis or undergoing diabetic hemodialysis. (PubMed id 19019211)1, 9 Kutsukake M....Tamura K. (2008)

    External Searches for IGFBP7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing IGFBP7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3490 HGNC: 5476 AceView: IGFBP7 Ensembl:ENSG00000163453 euGenes: HUgn3490
    ECgene: IGFBP7 H-InvDB: IGFBP7

    Other Databases showing IGFBP7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IGFBP7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGFBP7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGFBP7 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp7/

    Intellectual Property
    for IGFBP7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGFBP7 gene:
    Search GeneIP for patents involving IGFBP7

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