Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGFBP6 Gene

Aliases for IGFBP6 Gene

  • Insulin Like Growth Factor Binding Protein 6 2 3 5
  • IGFBP-6 3 4
  • IBP-6 3 4
  • IBP6 3 4
  • Insulin-Like Growth Factor Binding Protein 6 2
  • Insulin-Like Growth Factor-Binding Protein 6 3
  • IGF Binding Protein 6 3
  • IGF-Binding Protein 6 4

External Ids for IGFBP6 Gene

Previous GeneCards Identifiers for IGFBP6 Gene

  • GC12P053650
  • GC12P053405
  • GC12P053207
  • GC12P051777
  • GC12P053491
  • GC12P050534

Summaries for IGFBP6 Gene

GeneCards Summary for IGFBP6 Gene

IGFBP6 (Insulin Like Growth Factor Binding Protein 6) is a Protein Coding gene. Diseases associated with IGFBP6 include Exfoliative Ichthyosis and Insulin-Like Growth Factor I. Among its related pathways are Metabolism of proteins and Development IGF-1 receptor signaling. GO annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot for IGFBP6 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP6 Gene

Genomics for IGFBP6 Gene

Regulatory Elements for IGFBP6 Gene

Enhancers for IGFBP6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G053386 1.5 Ensembl ENCODE dbSUPER 19.4 +291.7 291735 6.3 ATF1 ZNF493 ZFP64 YY1 ZNF121 ZNF202 SP3 TSHZ1 REST ZNF623 ZNF740 SP1 AAAS CBX5 MAP3K12 ENSG00000258344 IGFBP6 LOC100652999 PRR13 PFDN5
GH12G053971 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +892.8 892807 36.8 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 ZNF740 MAP3K12 ENSG00000258344 LOC100652999 HOXC8 HOXC5 SP1 HOTAIR CBX5 HOXC4
GH12G053060 1.6 Ensembl ENCODE dbSUPER 12.2 -30.5 -30508 13.5 HDGF PKNOX1 FOXA2 MLX AGO1 ARID4B SIN3A YBX1 DMAP1 ZNF2 PFDN5 AAAS LOC283335 LOC100652999 IGFBP6 SOAT2 ZNF740 ITGB7 RNU6-333P ESPL1
GH12G052894 2 FANTOM5 Ensembl ENCODE dbSUPER 9.4 -194.5 -194509 16.1 MLX CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 AAAS ZNF740 MAP3K12 KRT18 SP1 SPRYD3 EIF4B LOC100652999 KRT74 KRT78
GH12G053095 1.4 ENCODE dbSUPER 12 +0.6 605 4.3 HDGF ARID4B SIN3A FEZF1 ZNF2 ZNF207 ZNF143 FOS DEK ZNF263 ZNF740 MAP3K12 IGFBP6 LOC100652999 SOAT2 SPRYD3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGFBP6 on UCSC Golden Path with GeneCards custom track

Promoters for IGFBP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052147 364 801 SIN3A FEZF1 ZNF2 GLIS2 KLF7 ZNF263 SP3 SP5 REST TSHZ1

Genomic Location for IGFBP6 Gene

Chromosome:
12
Start:
53,097,436 bp from pter
End:
53,102,345 bp from pter
Size:
4,910 bases
Orientation:
Plus strand

Genomic View for IGFBP6 Gene

Genes around IGFBP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP6 Gene

Proteins for IGFBP6 Gene

  • Protein details for IGFBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24592-IBP6_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 6
    Protein Accession:
    P24592
    Secondary Accessions:
    • Q14492

    Protein attributes for IGFBP6 Gene

    Size:
    240 amino acids
    Molecular mass:
    25322 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IGFBP6 Gene

neXtProt entry for IGFBP6 Gene

Post-translational modifications for IGFBP6 Gene

  • O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.
  • Glycosylation at isoforms=120, posLast=126126, isoforms=144, isoforms=145, posLast=146146, isoforms=152, isoforms=176, and posLast=184184
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBP6 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for IGFBP6

Protein Products

Assay Products

  • Cloud-Clone Corp. Assay Kits for IGFBP6
  • Abcam assays for IGFBP6

No data available for DME Specific Peptides for IGFBP6 Gene

Domains & Families for IGFBP6 Gene

Gene Families for IGFBP6 Gene

Suggested Antigen Peptide Sequences for IGFBP6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFBP6: view

No data available for UniProtKB/Swiss-Prot for IGFBP6 Gene

Function for IGFBP6 Gene

Molecular function for IGFBP6 Gene

GENATLAS Biochemistry:
insulin-like growth factor binding protein 6,of highest affinity,expressed in fibroblasts,in prostatic and ovarian cells,predominantly found in CSF and serum
UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Ontology (GO) - Molecular Function for IGFBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 24431302
GO:0005520 insulin-like growth factor binding IEA --
GO:0019838 growth factor binding IEA --
GO:0031994 insulin-like growth factor I binding IEA,IBA --
GO:0031995 insulin-like growth factor II binding IEA,IMP 15308688
genes like me logo Genes that share ontologies with IGFBP6: view
genes like me logo Genes that share phenotypes with IGFBP6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFBP6 Gene

Localization for IGFBP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP6 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
nucleus 1

Gene Ontology (GO) - Cellular Components for IGFBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IBA,IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0042568 insulin-like growth factor binary complex IMP 15308688
genes like me logo Genes that share ontologies with IGFBP6: view

Pathways & Interactions for IGFBP6 Gene

genes like me logo Genes that share pathways with IGFBP6: view

Pathways by source for IGFBP6 Gene

Gene Ontology (GO) - Biological Process for IGFBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007165 signal transduction NAS 10087296
GO:0008285 negative regulation of cell proliferation TAS 7539002
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway IBA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with IGFBP6: view

No data available for SIGNOR curated interactions for IGFBP6 Gene

Drugs & Compounds for IGFBP6 Gene

(11) Drugs for IGFBP6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for IGFBP6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP6: view

Transcripts for IGFBP6 Gene

Unigene Clusters for IGFBP6 Gene

Insulin-like growth factor binding protein 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: -
SP3: -

Relevant External Links for IGFBP6 Gene

GeneLoc Exon Structure for
IGFBP6
ECgene alternative splicing isoforms for
IGFBP6

Expression for IGFBP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFBP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBP6 Gene

This gene is overexpressed in Nerve - Tibial (x5.2).

Protein differential expression in normal tissues from HIPED for IGFBP6 Gene

This gene is overexpressed in Serum (24.8), Cerebrospinal fluid (11.6), Vitreous humor (10.9), Plasma (8.2), and Synovial fluid (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IGFBP6 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGFBP6 Gene:

IGFBP6

SOURCE GeneReport for Unigene cluster for IGFBP6 Gene:

Hs.274313

Evidence on tissue expression from TISSUES for IGFBP6 Gene

  • Nervous system(4.7)
  • Pancreas(4.3)
  • Muscle(3.1)
  • Stomach(2.5)
  • Adrenal gland(2.1)
  • Eye(2.1)
  • Heart(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with IGFBP6: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP6 Gene

Orthologs for IGFBP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBP6 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia IGFBP6 34 35
  • 85.67 (n)
cow
(Bos Taurus)
Mammalia IGFBP6 34 35
  • 85.65 (n)
rat
(Rattus norvegicus)
Mammalia Igfbp6 34
  • 77.5 (n)
mouse
(Mus musculus)
Mammalia Igfbp6 34 16 35
  • 77.41 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 32 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia IGFBP6 35
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii igfbp6a 35
  • 37 (a)
OneToMany
igfbp6b 35
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for IGFBP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP6 Gene

ENSEMBL:
Gene Tree for IGFBP6 (if available)
TreeFam:
Gene Tree for IGFBP6 (if available)

Paralogs for IGFBP6 Gene

Paralogs for IGFBP6 Gene

genes like me logo Genes that share paralogs with IGFBP6: view

Variants for IGFBP6 Gene

Sequence variations from dbSNP and Humsavar for IGFBP6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000948582 -- 53,102,506(+) GCTGC(C/T)CACCA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001104996 -- 53,096,682(+) CTGGG(A/C)ACAAG upstream-variant-2KB
rs1001124364 -- 53,099,771(+) TTAAG(C/T)AATTA intron-variant
rs1001740668 -- 53,099,486(+) ACCAC(A/G)TCTCA intron-variant
rs1002056412 -- 53,098,050(+) CCTGC(A/T)GGTGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IGFBP6 Gene

Variant ID Type Subtype PubMed ID
dgv2644n54 CNV loss 21841781
dgv2645n54 CNV loss 21841781
nsv470294 CNV loss 18288195
nsv470295 CNV gain 18288195
nsv517066 CNV loss 19592680
nsv712 CNV insertion 18451855
nsv832417 CNV gain 17160897

Variation tolerance for IGFBP6 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFBP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP6 Gene

Disorders for IGFBP6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IGFBP6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
exfoliative ichthyosis
  • autosomal recessive exfoliative ichthyosis
insulin-like growth factor i
  • insulin-like growth factor i deficiency
rhabdomyosarcoma
ichthyosis bullosa of siemens
  • bullous type ichthyosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGFBP6

Genetic Association Database (GAD)
IGFBP6
Human Genome Epidemiology (HuGE) Navigator
IGFBP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFBP6
genes like me logo Genes that share disorders with IGFBP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP6 Gene

Publications for IGFBP6 Gene

  1. Characterization and chromosomal localization of the human insulin- like growth factor-binding protein 6 gene. (PMID: 10087296) Ehrenborg E. … Luthman H. (Mamm. Genome 1999) 2 3 4 22 64
  2. The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry. (PMID: 10329650) Neumann G.M. … Bach L.A. (J. Biol. Chem. 1999) 3 4 22 64
  3. Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6. (PMID: 9572875) Neumann G.M. … Bach L.A. (Biochemistry 1998) 3 4 22 64
  4. Isolation and molecular cloning of insulin-like growth factor-binding protein-6. (PMID: 1719383) Shimasaki S. … Ling N. (Mol. Endocrinol. 1991) 3 4 22 64
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64

Products for IGFBP6 Gene

Sources for IGFBP6 Gene

Content
Loading form....