Aliases for IGFBP6 Gene
External Ids for IGFBP6 Gene
Previous GeneCards Identifiers for IGFBP6 Gene
GeneCards Summary for IGFBP6 Gene
IGFBP6 (Insulin Like Growth Factor Binding Protein 6) is a Protein Coding gene. Diseases associated with IGFBP6 include rhabdomyosarcoma and exfoliative ichthyosis. Among its related pathways are Transport to the Golgi and subsequent modification and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). GO annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP5.
UniProtKB/Swiss-Prot for IGFBP6 Gene
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.