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IGFBP6 Gene

protein-coding   GIFtS: 66
GCID: GC12P053491

Insulin-Like Growth Factor Binding Protein 6

  See IGFBP6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin-Like Growth Factor Binding Protein 61 2     IGF-Binding Protein 62 3
IBP-62 3     IGF Binding Protein 62
IBP62 3     Insulin-Like Growth Factor-Binding Protein 62
IGFBP-62 3     

External Ids:    HGNC: 54751   Entrez Gene: 34892   Ensembl: ENSG000001677797   OMIM: 1467355   UniProtKB: P245923   

Export aliases for IGFBP6 gene to outside databases

Previous GC identifers: GC12P053650 GC12P053405 GC12P053207 GC12P051777 GC12P050534


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGFBP6 Gene:
IGFBP6 (insulin-like growth factor binding protein 6) is a protein-coding gene. Diseases associated with IGFBP6 include pheochromocytoma. GO annotations related to this gene include insulin-like growth factor I binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot: IBP6_HUMAN, P24592
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
cell surface receptors

Gene Wiki entry for IGFBP6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGFBP6 gene promoter:
         NF-1   NF-1/L   ISGF-3   AP-1   ATF-2   HSF1 (long)   Lmo2   HSF1short   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFBP6 promoter sequence
   Search Chromatin IP Primers for IGFBP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFBP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

IGFBP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P053491:  view genomic region     (about GC identifiers)

Start:
53,491,220 bp from pter      End:
53,496,129 bp from pter
Size:
4,910 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IBP6_HUMAN, P24592 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 6 precursor  
Size: 240 amino acids; 25322 Da
1 PDB 3D structure from and Proteopedia for IGFBP6:
1RMJ (3D)    
Secondary accessions: Q14492

Explore the universe of human proteins at neXtProt for IGFBP6: NX_P24592

Explore proteomics data for IGFBP6 at MOPED

Post-translational modifications: 

  • O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues.
    O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168
    in cerebrospinal fluid1
  • Glycosylation2 at Ser120, Thr126, Ser144, Thr145, Thr146, Ser152, Thr176, Thr184
  • Modification sites at PhosphoSitePlus

  • See IGFBP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002169.1  
    ENSEMBL proteins: 
     ENSP00000448953   ENSP00000301464   ENSP00000449344  
    Reactome Protein details: P24592

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    antibodies-online proteins for IGFBP6 (24 products) 

     
    antibodies-online peptides for IGFBP6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR022326 IGFBP-6
     IPR000716 Thyroglobulin_1
     IPR022321 IGFBP_1-6_chordata
     IPR000867 IGFBP-like
     IPR009168 IGFBP1-6

    Graphical View of Domain Structure for InterPro Entry P24592

    ProtoNet protein and cluster: P24592

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB000867 Insulin-like growth factor-binding protein


    UniProtKB/Swiss-Prot: IBP6_HUMAN, P24592
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    Find genes that share domains with IGFBP6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBP6_HUMAN, P24592
    Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
    stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
    cell surface receptors

         Genatlas biochemistry entry for IGFBP6:
    insulin-like growth factor binding protein 6,of highest affinity,expressed in fibroblasts,in prostatic and ovarian
    cells,predominantly found in CSF and serum

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005520insulin-like growth factor binding ----
    GO:0031994insulin-like growth factor I binding IEA--
         
    Find genes that share ontologies with IGFBP6           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for IGFBP6:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased cell death HMECs cel 
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IGFBP6

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IBP6_HUMAN, P24592: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus2
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--

    Find genes that share ontologies with IGFBP6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGFBP6 About    
    See pathways by source

    SuperPathContained pathways About
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    2Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


    Find genes that share SuperPaths with IGFBP6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for IGFBP6
        Development IGF-1 receptor signaling

    1 BioSystems Pathway for IGFBP6
        Myometrial Relaxation and Contraction Pathways


    1 Reactome Pathway for IGFBP6
        Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGFBP6
    Interactions:

        GeneGlobe Interaction Network for IGFBP6

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for IGFBP6 (P245922, 3 ENSP000003014644) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2859967 MINT-2859986 I2D: score=3 STRING: ENSP00000357292
    IGF1P050193, ENSP000003026654I2D: score=2 STRING: ENSP00000302665
    TFP027873, ENSP000002649984I2D: score=1 STRING: ENSP00000264998
    IGF2P013443I2D: score=2 
    --C9JAF23I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0007165signal transduction NAS10087296
    GO:0008285negative regulation of cell proliferation TAS7539002
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with IGFBP6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGFBP6 (IBP6)

    Selected Novoseek inferred chemical compound relationships for IGFBP6 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 45.3 36 11914024 (6), 9795362 (4), 7532580 (3), 10970819 (3) (see all 8)
    retinoid 30.1 3 11267670 (1), 18957410 (1), 10970819 (1)
    forskolin 24.2 4 7532580 (2), 7505278 (1)
    thymidine 23 4 8708541 (1)
    ribonucleic acid 22.7 1 8772565 (1)
    diethylstilbestrol 22.3 12 15846301 (6), 7684977 (3)
    estrogen 21.4 27 19322032 (5), 7532580 (3), 17978469 (2), 18957410 (1) (see all 7)
    cycloheximide 18.4 1 8603611 (1)
    glycosaminoglycan 8.17 1 15914054 (1)
    calcium 3.52 1 7539002 (1)



    Find genes that share compounds with IGFBP6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IGFBP6 gene: 
    NM_002178.2  

    Unigene Cluster for IGFBP6:

    Insulin-like growth factor binding protein 6
    Hs.274313  [show with all ESTs]
    Unigene Representative Sequence: BM913156
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548547 ENST00000301464(uc001sbu.1) ENST00000548176 ENST00000549628

    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat IGFBP6

    Additional mRNA sequence: 

    AK313158.1 BC003507.1 BC005007.1 BC010162.2 BC011708.2 CR541791.1 M62402.1 M69054.1 

    10 DOTS entries:

    DT.114910  DT.121117484  DT.91750685  DT.121117971  DT.100786686  DT.95186900  DT.121118188  DT.95186901 
    DT.100876963  DT.95186904 

    Selected AceView cDNA sequences (see all 236):

    BQ675713 BI869587 BM702109 BM973869 AI191697 BM915339 BM888521 BQ002758 
    BM694369 CA488644 CR541791 AI685737 AA675888 BM809620 BM707982 BQ687291 
    NM_002178 AI659934 BC011708 BM704394 CD107239 AI597872 CA397562 CR590705 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:              -     -                                 
    SP2:              -                                       
    SP3:                    -                                 


    ECgene alternative splicing isoforms for IGFBP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGFBP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCCTCAC
    IGFBP6 Expression
    About this image


    IGFBP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone marrow-derived mesenchymal stem cells
             HyStem+BMP4-induced E15 cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipocytes Visceral White Adipose
             HyStem+BMP4-induced E15 cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Cartilage (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
     
     Eye (Sensory Organs)
             Cholinergic Amacrine Cells Inner Nuclear Layer
    IGFBP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGFBP6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.274313
        Custom PCR Arrays for IGFBP6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP6 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfbp61 , 5 insulin-like growth factor binding protein 61, 5 77.41(n)1
    72.9(a)1
      15 (57.32 cM)5
    160121  NM_008344.31  NP_032370.21 
     1021443625 
    lizard
    (Anolis carolinensis)
    Reptilia IGFBP66
    insulin-like growth factor binding protein 6
    44(a)
    1 ↔ 1
    GL343212.1(2737527-2742986)
    zebrafish
    (Danio rerio)
    Actinopterygii igfbp6a6
    igfbp6b6
    insulin-like growth factor binding protein 6b
    37(a)
    36(a)
    many → 1
    many → 1
    11(2369957-2376097) ENSDARG00000070941
    23(36648046-36651901) ENSDARG00000090833


    ENSEMBL Gene Tree for IGFBP6 (if available)
    TreeFam Gene Tree for IGFBP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGFBP6 gene
    IGFBP52  IGFBP22  IGFBP12  IGFBP32  IGFBP42  

    Find genes that share paralogs with IGFBP6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGFBP6 (see all 135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs754104731,2
    C,F--53489455(+) GTGGCG/AGGGTA 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1471015041,2
    --53489576(+) ACAAAC/TCTGCA 1 -- us2k10--------
    rs15547521,2
    C,F,H--53489678(+) CATCTC/TTTTCC 1 -- us2k1 trp35Minor allele frequency- T:0.02NS EA NA 410
    rs1819476691,2
    --53489703(+) CACAGC/GCTTTC 1 -- us2k10--------
    rs1136527251,2
    F--53489885(+) CAGGGG/TGTTGA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs289435981,2
    C,F--53489903(-) CCCTTT/CCACCA 1 -- us2k113Minor allele frequency- C:0.35NA EU CSAM EA NS MN WA 1514
    rs1495731141,2
    --53489955(+) CTCTGA/CCCTGG 1 -- us2k10--------
    rs1442320111,2
    --53490083(+) CATGTC/TCTAGG 1 -- us2k10--------
    rs1483340801,2
    --53490107(+) ATGGCA/GAAGCG 1 -- us2k10--------
    rs96585961,2
    C,F,H--53490127(+) GACAAT/CGAGGT 1 -- us2k114Minor allele frequency- C:0.02NS EA NA EU CSAM 1444

    HapMap Linkage Disequilibrium report for IGFBP6 (53491220 - 53496129 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IGFBP6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv712CNV Insertion18451855
    nsv470294CNV Loss18288195
    nsv899099CNV Loss21882294
    nsv517066CNV Loss19592680
    nsv470295CNV Gain18288195
    nsv832417CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146735    OMIM disorders: --

    1 disease for IGFBP6:    
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    pheochromocytoma


    Find genes that share disorders with IGFBP6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IGFBP6 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 47.8 2 18039785 (1), 15914054 (1)
    osteosarcoma 31.9 5 10512758 (1), 18395833 (1), 18724896 (1), 11914024 (1)
    growth retardation 31.8 1 10468926 (1)
    colon cancer 29.6 3 15914054 (1), 11604234 (1), 7542277 (1)
    renal failure chronic 19.3 4 10985760 (1), 10468926 (1), 9284730 (1)
    hypoglycemia 4.76 3 10468998 (2), 10468926 (1)
    endometrial cancer 4.33 2 7523316 (2)
    breast cancer 4.16 13 17287408 (4), 18957410 (2), 10069662 (2), 1373605 (1)
    tumors 0.432 7 18985860 (3), 12894236 (1), 15914054 (1), 7531847 (1)
    cancer 0.322 9 15914054 (1), 10980619 (1), 15846301 (1), 17519236 (1)

    Genetic Association Database (GAD): IGFBP6
    Human Genome Epidemiology (HuGE) Navigator: IGFBP6 (14 documents)

    Export disorders for IGFBP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGFBP6 gene, integrated from 10 sources (see all 197):
    (articles sorted by number of sources associating them with IGFBP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal localization of the human insulin- like growth factor-binding protein 6 gene. (PubMed id 10087296)1, 2, 3, 9 Ehrenborg E.... Luthman H. (Mamm. Genome 1999)
    2. Isolation and molecular cloning of insulin-like growth factor-binding protein-6. (PubMed id 1719383)1, 2, 9 Shimasaki S.... Ling N. (Mol. Endocrinol. 1991)
    3. Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6. (PubMed id 9572875)1, 2, 9 Neumann G.M.... Bach L.A. (Biochemistry 1998)
    4. The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry. (PubMed id 10329650)1, 2, 9 Neumann G.M. and Bach L.A. (J. Biol. Chem. 1999)
    5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    6. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    9. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PubMed id 19950226)1, 4 Kontorovich T....Friedman E. (Int. J. Cancer 2010)
    10. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3489 HGNC: 5475 AceView: IGFBP6 Ensembl:ENSG00000167779 euGenes: HUgn3489
    ECgene: IGFBP6 H-InvDB: IGFBP6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IGFBP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGFBP6 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGFBP6 gene:
    Search GeneIP for patents involving IGFBP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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