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Aliases for IGFBP6 Gene

Aliases for IGFBP6 Gene

  • Insulin Like Growth Factor Binding Protein 6 2 3 5
  • Insulin-Like Growth Factor Binding Protein 6 2 3
  • IGF-Binding Protein 6 3 4
  • IGFBP-6 3 4
  • IBP-6 3 4
  • IBP6 3 4
  • IGF Binding Protein 6 3

External Ids for IGFBP6 Gene

Previous GeneCards Identifiers for IGFBP6 Gene

  • GC12P053650
  • GC12P053405
  • GC12P053207
  • GC12P051777
  • GC12P053491
  • GC12P050534

Summaries for IGFBP6 Gene

GeneCards Summary for IGFBP6 Gene

IGFBP6 (Insulin Like Growth Factor Binding Protein 6) is a Protein Coding gene. Diseases associated with IGFBP6 include rhabdomyosarcoma and exfoliative ichthyosis. Among its related pathways are Transport to the Golgi and subsequent modification and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). GO annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot for IGFBP6 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP6 Gene

Genomics for IGFBP6 Gene

Regulatory Elements for IGFBP6 Gene

Enhancers for IGFBP6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IGFBP6 on UCSC Golden Path with GeneCards custom track

Promoters for IGFBP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IGFBP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGFBP6 Gene

Chromosome:
12
Start:
53,097,436 bp from pter
End:
53,102,345 bp from pter
Size:
4,910 bases
Orientation:
Plus strand

Genomic View for IGFBP6 Gene

Genes around IGFBP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP6 Gene

Proteins for IGFBP6 Gene

  • Protein details for IGFBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24592-IBP6_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 6
    Protein Accession:
    P24592
    Secondary Accessions:
    • Q14492

    Protein attributes for IGFBP6 Gene

    Size:
    240 amino acids
    Molecular mass:
    25322 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IGFBP6 Gene

neXtProt entry for IGFBP6 Gene

Proteomics data for IGFBP6 Gene at MOPED

Post-translational modifications for IGFBP6 Gene

  • O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.
  • Glycosylation at Ser 120, Thr 126, Ser 144, Thr 145, Thr 146, Ser 152, Thr 176, and Thr 184
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IGFBP6 Gene

Domains & Families for IGFBP6 Gene

Gene Families for IGFBP6 Gene

Suggested Antigen Peptide Sequences for IGFBP6 Gene

Graphical View of Domain Structure for InterPro Entry

P24592

UniProtKB/Swiss-Prot:

IBP6_HUMAN :
  • Contains 1 IGFBP N-terminal domain.
Domain:
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with IGFBP6: view

Function for IGFBP6 Gene

Molecular function for IGFBP6 Gene

GENATLAS Biochemistry:
insulin-like growth factor binding protein 6,of highest affinity,expressed in fibroblasts,in prostatic and ovarian cells,predominantly found in CSF and serum
UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Ontology (GO) - Molecular Function for IGFBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 24431302
genes like me logo Genes that share ontologies with IGFBP6: view
genes like me logo Genes that share phenotypes with IGFBP6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFBP6 Gene

Localization for IGFBP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFBP6 Gene COMPARTMENTS Subcellular localization image for IGFBP6 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
nucleus 1

Gene Ontology (GO) - Cellular Components for IGFBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with IGFBP6: view

Pathways & Interactions for IGFBP6 Gene

genes like me logo Genes that share pathways with IGFBP6: view

Pathways by source for IGFBP6 Gene

Gene Ontology (GO) - Biological Process for IGFBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 7539002
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway IBA --
GO:0044267 cellular protein metabolic process TAS --
GO:0090090 negative regulation of canonical Wnt signaling pathway TAS 24431302
genes like me logo Genes that share ontologies with IGFBP6: view

No data available for SIGNOR curated interactions for IGFBP6 Gene

Drugs & Compounds for IGFBP6 Gene

(11) Drugs for IGFBP6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for IGFBP6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP6: view

Transcripts for IGFBP6 Gene

Unigene Clusters for IGFBP6 Gene

Insulin-like growth factor binding protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: -
SP3: -

Relevant External Links for IGFBP6 Gene

GeneLoc Exon Structure for
IGFBP6
ECgene alternative splicing isoforms for
IGFBP6

Expression for IGFBP6 Gene

mRNA expression in normal human tissues for IGFBP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBP6 Gene

This gene is overexpressed in Nerve - Tibial (x5.2).

Protein differential expression in normal tissues from HIPED for IGFBP6 Gene

This gene is overexpressed in Serum (24.8), Cerebrospinal fluid (11.6), Vitreous humor (10.9), Plasma (8.2), and Synovial fluid (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGFBP6 Gene



SOURCE GeneReport for Unigene cluster for IGFBP6 Gene Hs.274313

genes like me logo Genes that share expression patterns with IGFBP6: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IGFBP6 Gene

Orthologs for IGFBP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IGFBP6 35
  • 85.65 (n)
  • 83.8 (a)
IGFBP6 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGFBP6 35
  • 85.67 (n)
  • 85.02 (a)
IGFBP6 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igfbp6 35
  • 77.41 (n)
  • 72.9 (a)
Igfbp6 16
Igfbp6 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IGFBP6 35
  • 99.44 (n)
  • 99.17 (a)
IGFBP6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igfbp6 35
  • 77.5 (n)
  • 73 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 32 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia IGFBP6 36
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii igfbp6a 36
  • 37 (a)
OneToMany
igfbp6b 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for IGFBP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP6 Gene

ENSEMBL:
Gene Tree for IGFBP6 (if available)
TreeFam:
Gene Tree for IGFBP6 (if available)

Paralogs for IGFBP6 Gene

Paralogs for IGFBP6 Gene

genes like me logo Genes that share paralogs with IGFBP6: view

Variants for IGFBP6 Gene

Sequence variations from dbSNP and Humsavar for IGFBP6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_011907 -
VAR_018932 -
VAR_018933 -
VAR_049565 -
rs711314 -- 53,096,640(+) GTAGG(C/T)AGGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IGFBP6 Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680
nsv899099 CNV Loss 21882294
nsv470294 CNV Loss 18288195
nsv712 CNV Insertion 18451855
nsv832417 CNV Gain 17160897
nsv470295 CNV Gain 18288195

Variation tolerance for IGFBP6 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFBP6 Gene

HapMap Linkage Disequilibrium report
IGFBP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP6 Gene

Disorders for IGFBP6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IGFBP6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rhabdomyosarcoma
exfoliative ichthyosis
  • autosomal recessive exfoliative ichthyosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGFBP6

Genetic Association Database (GAD)
IGFBP6
Human Genome Epidemiology (HuGE) Navigator
IGFBP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFBP6
genes like me logo Genes that share disorders with IGFBP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP6 Gene

Publications for IGFBP6 Gene

  1. Characterization and chromosomal localization of the human insulin- like growth factor-binding protein 6 gene. (PMID: 10087296) Ehrenborg E. … Luthman H. (Mamm. Genome 1999) 2 3 4 23 67
  2. Rexinoid-induced expression of IGFBP-6 requires RARbeta-dependent permissive cooperation of retinoid receptors and AP-1. (PMID: 18957410) Uray I.P. … Brown P.H. (J. Biol. Chem. 2009) 3 23
  3. A functional nuclear localization signal in insulin-like growth factor binding protein-6 mediates its nuclear import. (PMID: 18039785) Iosef C. … Han V.K. (Endocrinology 2008) 3 23
  4. Potential involvement of the interaction between insulin-like growth factor binding protein (IGFBP)-6 and LIM mineralization protein (LMP)-1 in regulating osteoblast differentiation. (PMID: 18395833) Strohbach C. … Strong D. (J. Cell. Biochem. 2008) 3 23
  5. [Effect of dioxin on apoptosis of osteogenic sarcoma cells and regulation on gene expression of insulin-like growth factor binding protein 6]. (PMID: 18724896) Guo L. … Gao X.Y. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2008) 3 23

Products for IGFBP6 Gene

Sources for IGFBP6 Gene

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