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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGFBP6 Gene

protein-coding   GIFtS: 66
GCID: GC12P053491

Insulin-Like Growth Factor Binding Protein 6

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin-Like Growth Factor Binding Protein 61 2     IGF-Binding Protein 62 3
IBP-62 3     IGF Binding Protein 62
IBP62 3     Insulin-Like Growth Factor-Binding Protein 62
IGFBP-62 3     

External Ids:    HGNC: 54751   Entrez Gene: 34892   Ensembl: ENSG000001677797   OMIM: 1467355   UniProtKB: P245923   

Export aliases for IGFBP6 gene to outside databases

Previous GC identifers: GC12P053650 GC12P053405 GC12P053207 GC12P051777 GC12P050534


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGFBP6 Gene: 
IGFBP6 (insulin-like growth factor binding protein 6) is a protein-coding gene. Diseases associated with IGFBP6 include exfoliative ichthyosis, and proliferative vitreoretinopathy, and among its related super-pathways are Signal transduction AKT signaling and Calcium Regulation in the Cardiac Cell. GO annotations related to this gene include insulin-like growth factor I binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot: IBP6_HUMAN, P24592
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
cell surface receptors

Gene Wiki entry for IGFBP6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGFBP6 gene promoter:
         NF-1   NF-1/L   ISGF-3   AP-1   ATF-2   HSF1 (long)   Lmo2   HSF1short   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFBP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGFBP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

IGFBP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P053491:  view genomic region     (about GC identifiers)

Start:
53,491,220 bp from pter      End:
53,496,129 bp from pter
Size:
4,910 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IBP6_HUMAN, P24592 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 6 precursor  
Size: 240 amino acids; 25322 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for IGFBP6:
1RMJ (3D)    
Secondary accessions: Q14492

Explore the universe of human proteins at neXtProt for IGFBP6: NX_P24592

Explore proteomics data for IGFBP6 at MOPED 

Post-translational modifications:

  • UniProtKB: O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues.
    O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168
    in cerebrospinal fluid
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P24592

  • IGFBP6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGFBP6 Protein Expression
    REFSEQ proteins: NP_002169.1  
    ENSEMBL proteins: 
     ENSP00000448953   ENSP00000301464   ENSP00000449344  
    Reactome Protein details: P24592
    Human Recombinant Protein Products for IGFBP6: 
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    Novus Biologicals IGFBP6 Proteins
    Novus Biologicals IGFBP6 Lysates
    Sino Biological Recombinant Protein for IGFBP6
    Sino Biological Cell Lysate for IGFBP6 
    ProSpec Recombinant Protein for IGFBP6
    Cloud-Clone Corp. Proteins for IGFBP6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--

    IGFBP6 for ontologies           About GeneDecksing



    IGFBP6 Antibody Products: 
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    Assay Products for IGFBP6: 
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    Cloud-Clone Corp. ELISAs for IGFBP6 
    Cloud-Clone Corp. CLIAs for IGFBP6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR022326 IGFBP-6
     IPR000716 Thyroglobulin_1
     IPR022321 IGFBP_1-6_chordata
     IPR000867 IGFBP-like
     IPR009168 IGFBP1-6

    Graphical View of Domain Structure for InterPro Entry P24592

    ProtoNet protein and cluster: P24592

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB000867 Insulin-like growth factor-binding protein


    UniProtKB/Swiss-Prot: IBP6_HUMAN, P24592
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    IGFBP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBP6_HUMAN, P24592
    Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
    stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
    cell surface receptors

         Genatlas biochemistry entry for IGFBP6:
    insulin-like growth factor binding protein 6,of highest affinity,expressed in fibroblasts,in prostatic and ovarian
    cells,predominantly found in CSF and serum

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005520insulin-like growth factor binding ----
    GO:0031994insulin-like growth factor I binding IEA--
         
    IGFBP6 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for IGFBP6:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased cell death HMECs cel 
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGFBP6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGFBP6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGFBP6 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGFBP6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    2Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IGFBP6
        Development IGF-RI signaling


    1 GeneGo (Thomson Reuters) Pathway for IGFBP6
        Development IGF-1 receptor signaling

    1 BioSystems Pathway for IGFBP6
        Myometrial Relaxation and Contraction Pathways


    2        Reactome Pathways for IGFBP6
        Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Metabolism of proteins



    IGFBP6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGFBP6

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for IGFBP6 (P245922, 3 ENSP000003014644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2859967 MINT-2859986 I2D: score=3 STRING: ENSP00000357292
    IGF1P050193, ENSP000003026654I2D: score=2 STRING: ENSP00000302665
    IGF2P013443, ENSP000003382974I2D: score=2 STRING: ENSP00000338297
    TFP027873, ENSP000002649984I2D: score=1 STRING: ENSP00000264998
    --C9JAF23I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0007165signal transduction NAS10087296
    GO:0008285negative regulation of cell proliferation TAS7539002
    GO:0044267cellular protein metabolic process TAS--

    IGFBP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGFBP6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGFBP6 (IBP6)

    10/16 Novoseek inferred chemical compound relationships for IGFBP6 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 45.3 36 11914024 (6), 9795362 (4), 7532580 (3), 10970819 (3) (see all 8)
    retinoid 30.1 3 11267670 (1), 18957410 (1), 10970819 (1)
    forskolin 24.2 4 7532580 (2), 7505278 (1)
    thymidine 23 4 8708541 (1)
    ribonucleic acid 22.7 1 8772565 (1)
    diethylstilbestrol 22.3 12 15846301 (6), 7684977 (3)
    estrogen 21.4 27 19322032 (5), 7532580 (3), 17978469 (2), 18957410 (1) (see all 7)
    cycloheximide 18.4 1 8603611 (1)
    glycosaminoglycan 8.17 1 15914054 (1)
    calcium 3.52 1 7539002 (1)

    Search CenterWatch for drugs/clinical trials and news about IGFBP6 / IBP6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IGFBP6 gene: 
    NM_002178.2  

    Unigene Cluster for IGFBP6:

    Insulin-like growth factor binding protein 6
    Hs.274313  [show with all ESTs]
    Unigene Representative Sequence: BM913156
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548547 ENST00000301464(uc001sbu.1) ENST00000548176 ENST00000549628

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBP6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP6

    Additional mRNA sequence: 

    AK313158.1 BC003507.1 BC005007.1 BC010162.2 BC011708.2 CR541791.1 M62402.1 M69054.1 

    10 DOTS entries:

    DT.114910  DT.121117484  DT.91750685  DT.121117971  DT.100786686  DT.95186900  DT.121118188  DT.95186901 
    DT.100876963  DT.95186904 

    24/236 AceView cDNA sequences (see all 236):

    AI685737 BQ687291 BQ717490 AA675888 BM915339 BQ687249 BM707982 CD516577 
    CA407026 CD516619 AW844962 BM702109 BQ680755 BM704394 CR590705 AI659934 
    BQ878237 CA397562 BM888336 BQ945587 BM888521 BM809620 BQ675713 BC011708 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:              -     -                                 
    SP2:              -                                       
    SP3:                    -                                 


    ECgene alternative splicing isoforms for IGFBP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGFBP6 expression in normal human tissues (normalized intensities)      IGFBP6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCCTCAC
    IGFBP6 Expression
    About this image


    IGFBP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced E15 cells
             Human Annulus Fibrosus Cells (HAFC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
             HyStem+BMP4-induced E15 cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Trigeminal Ganglion   
     
     Smooth Muscle (Muscoskeletal System)
             Human Tracheal Smooth Muscle Cells (HTSMC)   
     
     Colon (Gastrointestinal Tract)
             Appendix   

    See IGFBP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGFBP6

    SOURCE GeneReport for Unigene cluster: Hs.274313
        SABiosciences Custom PCR Arrays for IGFBP6
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP6 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfbp61 , 5 insulin-like growth factor binding protein 61, 5 77.34(n)1
    72.37(a)1
      15 (57.32 cM)5
    160121  NM_008344.31  NP_032370.21 
     1021443625 
    lizard
    (Anolis carolinensis)
    Reptilia IGFBP66
    Uncharacterized protein
    43(a)
    1 ↔ 1
    GL343212.1(2737527-2742986)
    zebrafish
    (Danio rerio)
    Actinopterygii igfbp6b6
    igfbp6a6
    insulin-like growth factor binding protein 6a
    37(a)
    35(a)
    many → 1
    many → 1
    23(36648046-36651901)
    11(2369957-2376097)


    ENSEMBL Gene Tree for IGFBP6 (if available)
    TreeFam Gene Tree for IGFBP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGFBP6 gene
    IGFBP52  IGFBP22  IGFBP12  IGFBP32  IGFBP42  

    IGFBP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/135 SNPs in IGFBP6 are shown (see all 135)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0119074
    ----see VAR_0119072 T P mis40--------
    VAR_0189334
    ----see VAR_0189332 R Q mis40--------
    rs754104731,2
    C,F--53489455(+) GTGGCG/AGGGTA 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1471015041,2
    --53489576(+) ACAAAC/TCTGCA 1 -- us2k10--------
    rs15547521,2
    C,F,H--53489678(+) CATCTC/TTTTCC 1 -- us2k1 trp35Minor allele frequency- T:0.02NS EA NA 410
    rs1819476691,2
    --53489703(+) CACAGC/GCTTTC 1 -- us2k10--------
    rs1136527251,2
    F--53489885(+) CAGGGG/TGTTGA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs289435981,2
    C,F--53489903(-) CCCTTT/CCACCA 1 -- us2k113Minor allele frequency- C:0.35NA EU CSAM EA NS MN WA 1514
    rs1495731141,2
    --53489955(+) CTCTGA/CCCTGG 1 -- us2k10--------
    rs1442320111,2
    --53490083(+) CATGTC/TCTAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IGFBP6 (53491220 - 53496129 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IGFBP6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv712CNV Insertion18451855
    nsv470294CNV Loss18288195
    nsv899099CNV Loss21882294
    nsv517066CNV Loss19592680
    nsv470295CNV Gain18288195
    nsv832417CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 146735    OMIM disorders: --

    20/35 diseases for IGFBP6 (see all 35):    About MalaCards
    exfoliative ichthyosis    proliferative vitreoretinopathy    desmoid tumor    sotos syndrome
    papillary renal cell carcinoma    renal osteodystrophy    hypoglycemia    pheochromocytoma
    ichthyosis    osteosarcoma    rhabdomyosarcoma    conjunctivitis
    renal cell carcinoma    polycystic ovary syndrome    colon cancer    hyperparathyroidism
    acute lymphoblastic leukemia    neuroblastoma    endometrial carcinoma    lymphoblastic leukemia


    IGFBP6 for disorders           About GeneDecksing

    10/14 Novoseek inferred disease relationships for IGFBP6 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 47.8 2 18039785 (1), 15914054 (1)
    osteosarcoma 31.9 5 10512758 (1), 18395833 (1), 18724896 (1), 11914024 (1)
    growth retardation 31.8 1 10468926 (1)
    colon cancer 29.6 3 15914054 (1), 11604234 (1), 7542277 (1)
    renal failure chronic 19.3 4 10985760 (1), 10468926 (1), 9284730 (1)
    hypoglycemia 4.76 3 10468998 (2), 10468926 (1)
    endometrial cancer 4.33 2 7523316 (2)
    breast cancer 4.16 13 17287408 (4), 18957410 (2), 10069662 (2), 1373605 (1)
    tumors 0.432 7 18985860 (3), 12894236 (1), 15914054 (1), 7531847 (1)
    cancer 0.322 9 15914054 (1), 10980619 (1), 15846301 (1), 17519236 (1)

    Genetic Association Database (GAD): IGFBP6
    Human Genome Epidemiology (HuGE) Navigator: IGFBP6 (14 documents)

    Export disorders for IGFBP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGFBP6 gene, integrated from 9 sources (see all 196):
    (articles sorted by number of sources associating them with IGFBP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal localization of the human insulin- like growth factor-binding protein 6 gene. (PubMed id 10087296)1, 2, 3, 9 Ehrenborg E.... Luthman H. (1999)
    2. Isolation and molecular cloning of insulin-like growth factor-binding protein-6. (PubMed id 1719383)1, 2, 9 Shimasaki S.... Ling N. (1991)
    3. Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6. (PubMed id 9572875)1, 2, 9 Neumann G.M.... Bach L.A. (1998)
    4. The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry. (PubMed id 10329650)1, 2, 9 Neumann G.M. and Bach L.A. (1999)
    5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    6. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolis m and breast cancer risk in the NCI breast and prostate cancer cohort consortiu m. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (2010)
    9. Eighteen insulin-like growth factor pathway genes, ci rculating levels of IGF-I and its binding protein, and risk of prostate and bre ast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (2010)
    10. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3489 HGNC: 5475 AceView: IGFBP6 Ensembl:ENSG00000167779 euGenes: HUgn3489
    ECgene: IGFBP6 H-InvDB: IGFBP6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGFBP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGFBP6 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGFBP6 gene:
    Search GeneIP for patents involving IGFBP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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