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IGFBP5 Gene

protein-coding   GIFtS: 66
GCID: GC02M217504

Insulin-Like Growth Factor Binding Protein 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin-Like Growth Factor Binding Protein 51 2
IBP52 3 5
IBP-52 3
IGFBP-52 3
IGF-Binding Protein 52 3
Insulin-Like Growth Factor-Binding Protein 52

External Ids:    HGNC: 54741   Entrez Gene: 34882   Ensembl: ENSG000001154617   OMIM: 1467345   UniProtKB: P245933   

Export aliases for IGFBP5 gene to outside databases

Previous GC identifers: GC02M215637 GC02M216262 GC02M217743 GC02M217362 GC02M217245 GC02M209391


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGFBP5 Gene:
IGFBP5 (insulin-like growth factor binding protein 5) is a protein-coding gene. Diseases associated with IGFBP5 include mn1, and 3-m syndrome. GO annotations related to this gene include insulin-like growth factor I binding and fibronectin binding. An important paralog of this gene is IGFBP2.

UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
cell surface receptors

Gene Wiki entry for IGFBP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGFBP5 gene promoter:
         AP-1   ATF-2   Nkx2-5   STAT5A   STAT3   c-Myb   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFBP5 promoter sequence
   Search Chromatin IP Primers for IGFBP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFBP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q36   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q33-q36

IGFBP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M217504:  view genomic region     (about GC identifiers)

Start:
217,536,828 bp from pter      End:
217,560,272 bp from pter
Size:
23,445 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 5 precursor  
Size: 272 amino acids; 30570 Da
2 PDB 3D structures from and Proteopedia for IGFBP5:
1BOE (3D)        1H59 (3D)    
Secondary accessions: Q5U0A3

Explore the universe of human proteins at neXtProt for IGFBP5: NX_P24593

Explore proteomics data for IGFBP5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr123, Thr131, Thr172
  • Modification sites at PhosphoSitePlus

  • See IGFBP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000590.1  
    ENSEMBL proteins: 
     ENSP00000233813   ENSP00000413474  
    Reactome Protein details: P24593

    IGFBP5 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for IGFBP5
    Cloud-Clone Corp. Proteins for IGFBP5

    IGFBP5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IGFBP5
    R&D Systems Antibodies for IGFBP5 (IGFBP-5)
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    OriGene Custom Antibody Services for IGFBP5
    Novus Biologicals IGFBP5 Antibodies
    Abcam antibodies for IGFBP5
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    LSBio Antibodies in human, mouse, rat for IGFBP5

    IGFBP5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for IGFBP5 (IGFBP-5)
    GenScript Custom Assay Services for IGFBP5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IGFBP5
    Cloud-Clone Corp. CLIAs for IGFBP5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR000716 Thyroglobulin_1
     IPR022321 IGFBP_1-6_chordata
     IPR000867 IGFBP-like
     IPR009168 IGFBP1-6
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry P24593

    ProtoNet protein and cluster: P24593

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB000867 Insulin-like growth factor-binding protein


    UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    IGFBP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBP5_HUMAN, P24593
    Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
    stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
    cell surface receptors

         Genatlas biochemistry entry for IGFBP5:
    insulin-like growth factor binding protein 5,high affinity,complexing with IGF1 and IGF2 and acid labile subunit
    expressed predominantly in kidney,fetal tissues,adult conective tissues and CSF,present in the serum but
    decreasing with age after puberty. Binding to bone cells (skeletal growth factor)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005515protein binding IPI15700281
    GO:0005520insulin-like growth factor binding ----
    GO:0031994insulin-like growth factor I binding IPI10766744
         
    IGFBP5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IGFBP5:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Igfbp5):
     adipose tissue  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  muscle 

    IGFBP5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Igfbp5tm1Jep for IGFBP5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGFBP5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGFBP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGFBP5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGFBP5

    miRNA
    Products:
        
    miRTarBase miRNAs that target IGFBP5:
    hsa-mir-17-5p (MIRT050836), hsa-mir-331-3p (MIRT043414), hsa-mir-140-5p (MIRT006556)

    Block miRNA regulation of human, mouse, rat IGFBP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGFBP5 (see all 93):
    hsa-miR-411* hsa-miR-549 hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-193a-3p hsa-miR-642a hsa-miR-1321 hsa-miR-632
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IGFBP5
    Predesigned siRNA for gene silencing in human, mouse, rat IGFBP5

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IGFBP5

    Clone
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    GenScript: all cDNA clones in your preferred vector: IGFBP5 (NM_000599)
    Sino Biological Human cDNA Clone for IGFBP5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP5

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IBP5_HUMAN, P24593: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0016942insulin-like growth factor binding protein complex IC10766744

    IGFBP5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGFBP5 About    
    See pathways by source

    SuperPathContained pathways About
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    2Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Senescence and Autophagy
    Senescence and Autophagy
    5Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for IGFBP5
        Development IGF-1 receptor signaling

    2 BioSystems Pathways for IGFBP5
        Myometrial Relaxation and Contraction Pathways
    Senescence and Autophagy


    1 Reactome Pathway for IGFBP5
        Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)



    IGFBP5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGFBP5 (see all 7): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IGFBP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for IGFBP5 (P245932, 3 ENSP000002338134) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-63608 I2D: score=5 
    ENSG00000096155P463792, 3MINT-63608 I2D: score=5 
    ENSG00000227761P463792, 3MINT-63608 I2D: score=5 
    ENSG00000228760P463792, 3MINT-63608 I2D: score=5 
    ENSG00000229524P463792, 3MINT-63608 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0001649osteoblast differentiation IEA--
    GO:0006006glucose metabolic process IEA--
    GO:0007165signal transduction NAS7525452
    GO:0010906regulation of glucose metabolic process IEA--

    IGFBP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGFBP5 (IBP5)

    Selected Novoseek inferred chemical compound relationships for IGFBP5 gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribonucleic acid 45.9 2 8855838 (1)
    eb 1089 45.8 5 10427145 (2)
    heparin 43 51 8626396 (6), 7538367 (3), 7519608 (3), 9374687 (3) (see all 18)
    estrogen 36.1 15 11054645 (2), 17675285 (2), 18373644 (1), 17555868 (1) (see all 9)
    procollagen 36 4 11054645 (1), 14517421 (1), 9700476 (1)
    1,25 dihydroxy vitamin d3 34.8 1 9199505 (1)
    serine 31.2 28 9528953 (3), 9838220 (2), 15534875 (2), 7523096 (2) (see all 12)
    heparan sulfate 28.2 1 9786878 (1)
    thymidine 26.1 4 10801263 (1), 8817658 (1), 8997222 (1), 11691647 (1)
    retinoic acid 25.2 30 8603611 (4), 15777798 (4), 9367833 (3), 17242174 (2) (see all 11)



    IGFBP5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IGFBP5 gene: 
    NM_000599.3  

    Unigene Cluster for IGFBP5:

    Insulin-like growth factor binding protein 5
    Hs.607212  [show with all ESTs]
    Unigene Representative Sequence: NM_000599
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233813(uc002vgj.4) ENST00000486341 ENST00000449583
    miRNA
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    Block miRNA regulation of human, mouse, rat IGFBP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGFBP5 (see all 93):
    hsa-miR-411* hsa-miR-549 hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-193a-3p hsa-miR-642a hsa-miR-1321 hsa-miR-632
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      QuantiTect SYBR Green Assays in human, mouse, rat IGFBP5
      QuantiFast Probe-based Assays in human, mouse, rat IGFBP5

    Additional mRNA sequence: 

    AF055033.1 AF147308.1 AK309609.1 AK314992.1 BC008099.1 BC011453.1 BC018427.1 BC032366.1 
    BC039838.1 BC046102.1 BC073984.1 BC089383.1 BC133664.1 BT019706.1 BT019707.1 CR456809.1 
    L27560.1 M62782.1 M65062.1 

    Selected DOTS entries (see all 31):

    DT.75170481  DT.100705038  DT.100884425  DT.91728428  DT.100671612  DT.100697391  DT.120931735  DT.100884427 
    DT.97868293  DT.97775790  DT.120931724  DT.95305798  DT.102838850  DT.120931756  DT.95370309  DT.97793699 
    DT.120931741  DT.100672615  DT.100760287  DT.120931738  DT.120931755  DT.120931799  DT.120931832  DT.120931834 

    Selected AceView cDNA sequences (see all 826):

    CA396316 BF446409 CN484762 CD172291 BX390487 CD514994 AL047251 CA946503 
    AA029180 AW297513 CA392292 BC018427 BM683540 CD678937 BM990142 CA434548 
    CN481841 AI457248 BM694479 AI952530 CF131579 CO393416 AI749976 F09479 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGFBP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAAGCATT
    IGFBP5 Expression
    About this image


    IGFBP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 30) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             Midbrain dopaminergic-like neurons
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             S-shaped Body
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
    IGFBP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGFBP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.607212

    UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593
    Tissue specificity: Osteosarcoma, and at lower levels in liver, kidney and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGFBP5 (see all 7): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Prostate Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IGFBP5
    OriGene qSTAR qPCR primer pairs in human, mouse for IGFBP5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IGFBP5
    QuantiTect SYBR Green Assays in human, mouse, rat IGFBP5
    QuantiFast Probe-based Assays in human, mouse, rat IGFBP5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfbp51 , 5 insulin-like growth factor binding protein 51, 5 91.47(n)1
    96.85(a)1
      1 (36.94 cM)5
    160111  NM_010518.21  NP_034648.21 
     728579325 
    chicken
    (Gallus gallus)
    Aves IGFBP51 insulin-like growth factor binding protein 5 80.61(n)
    82.47(a)
      424220  XM_422069.4  XP_422069.3 
    lizard
    (Anolis carolinensis)
    Reptilia IGFBP56
    insulin-like growth factor binding protein 5
    79(a)
    1 ↔ 1
    GL343674.1(245029-248542)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52662 Xenopus laevis insulin-like growth factor binding protein more 78.19(n)    AY052629.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.249762 Danio rerio insulin-like growth factor binding protein more 77.9(n)    AY100478.1 


    ENSEMBL Gene Tree for IGFBP5 (if available)
    TreeFam Gene Tree for IGFBP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGFBP5 gene
    IGFBP22  IGFBP12  IGFBP62  IGFBP32  IGFBP42  
    2 SIMAP similar genes for IGFBP5 using alignment to 4 protein entries:     IBP5_HUMAN (see all proteins):
    IGFBP4    IGFBP3

    IGFBP5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGFBP5 (see all 550)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs46741071,2
    C,F,H--216919913(+) TTAAAA/CTCTTC 1 -- ds500125Minor allele frequency- C:0.22NA NS EA 2664
    rs764985711,2
    F--216920067(+) TTGGGG/CACATT 1 -- ds50011Minor allele frequency- C:0.02EA 120
    rs1402855741,2
    --216920092(+) TCACAA/GCAGCT 1 -- ds50010--------
    rs1503590091,2
    --216920115(+) ACCCAC/TAAGGA 1 -- ds50010--------
    rs1128028721,2
    C,F--216920135(+) CTGAGG/AAGGTT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs118949931,2
    C,F,A,H--216920153(+) TTGCCT/CTGGGT 1 -- ds500112Minor allele frequency- C:0.11NA NS EA WA CSA 785
    rs1437005431,2
    --216920163(+) TTCCAC/TGACTG 1 -- ds50010--------
    rs783676961,2
    C,F--216920190(+) GATGGG/CGAAGG 1 -- ds50011Minor allele frequency- C:0.09EA 120
    rs118893961,2
    C,F,H--216920262(+) GTGGCC/TGCTCA 1 -- ds50018Minor allele frequency- T:0.09NS EA WA NA CSA 533
    rs1132223531,2
    C,F--216920331(+) CAGGGG/ACTTGC 1 -- ds50011Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for IGFBP5 (217536828 - 217560272 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IGFBP5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522718CNV Loss19592680
    nsv460098CNV Loss19166990

    Human Gene Mutation Database (HGMD): IGFBP5
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGFBP5
    DNA2.0 Custom Variant and Variant Library Synthesis for IGFBP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146734    OMIM disorders: --

    Selected diseases for IGFBP5 (see all 64):    
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    mn1    3-m syndrome    renal osteodystrophy    differentiating neuroblastoma
    papillary renal cell carcinoma    estrogen-receptor positive breast cancer    acromegaly    lung squamous cell carcinoma
    hyperparathyroidism    fibrous histiocytoma    congenital disorder of glycosylation    histiocytoma
    osteosarcoma    keratoconus    endometrial adenocarcinoma    hyperthyroidism
    idiopathic pulmonary fibrosis    osteoporosis    pulmonary fibrosis    goiter


    IGFBP5 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for IGFBP5 gene (see all 39)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteosarcoma 47.2 16 16269403 (2), 18161051 (1), 7684391 (1), 11996908 (1) (see all 11)
    breast cancer 35.9 72 12777377 (6), 19341485 (5), 17651454 (5), 15802501 (4) (see all 22)
    breast carcinoma 27.6 6 18373644 (4), 9660801 (1), 1280130 (1)
    fibrosis idiopathic pulmonary 24.4 2 17071587 (1), 19628764 (1)
    renal osteodystrophy 18.1 2 10657717 (1), 10652019 (1)
    tumors 16.7 44 10850457 (3), 18775916 (3), 10218991 (3), 15618969 (2) (see all 21)
    prostate cancer 15.2 12 10850457 (4), 10830316 (2), 10218991 (1), 17823924 (1)
    glioblastoma 13.6 5 16700616 (1), 14515014 (1), 16619307 (1), 9213226 (1) (see all 5)
    bone loss 12.6 3 9795371 (2), 8817691 (1)
    bone diseases 11.8 1 10652019 (1)

    Genetic Association Database (GAD): IGFBP5
    Human Genome Epidemiology (HuGE) Navigator: IGFBP5 (19 documents)

    Export disorders for IGFBP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGFBP5 gene, integrated from 10 sources (see all 435):
    (articles sorted by number of sources associating them with IGFBP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. (PubMed id 7511611)1, 2, 3, 9 Allander S.V.... Powell D.R. (J. Biol. Chem. 1994)
    2. Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. (PubMed id 18210156)1, 4, 9 Garner C.P....Neuhausen S.L. (Hum. Genet. 2008)
    3. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers. (PubMed id 19843326)1, 4, 9 Neuhausen S.L....Gillen D.L. (Breast Cancer Res. 2009)
    4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PubMed id 19950226)1, 4 Kontorovich T....Friedman E. (Int. J. Cancer 2010)
    8. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    10. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3488 HGNC: 5474 AceView: IGFBP5 Ensembl:ENSG00000115461 euGenes: HUgn3488
    ECgene: IGFBP5 H-InvDB: IGFBP5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGFBP5 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGFBP5 gene:
    Search GeneIP for patents involving IGFBP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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