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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGFBP5 Gene

protein-coding   GIFtS: 65
GCID: GC02M217504

Insulin-Like Growth Factor Binding Protein 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin-Like Growth Factor Binding Protein 51 2
IBP52 3 5
IBP-52 3
IGFBP-52 3
IGF-Binding Protein 52 3
Insulin-Like Growth Factor-Binding Protein 52

External Ids:    HGNC: 54741   Entrez Gene: 34882   Ensembl: ENSG000001154617   OMIM: 1467345   UniProtKB: P245933   

Export aliases for IGFBP5 gene to outside databases

Previous GC identifers: GC02M215637 GC02M216262 GC02M217743 GC02M217362 GC02M217245 GC02M209391


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGFBP5 Gene: 
IGFBP5 (insulin-like growth factor binding protein 5) is a protein-coding gene. Diseases associated with IGFBP5 include 3-m syndrome, and mn1, and among its related super-pathways are Signal transduction AKT signaling and Calcium Regulation in the Cardiac Cell. GO annotations related to this gene include insulin-like growth factor I binding and fibronectin binding. An important paralog of this gene is IGFBP2.

UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
cell surface receptors

Gene Wiki entry for IGFBP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGFBP5 gene promoter:
         AP-1   ATF-2   Nkx2-5   STAT5A   STAT3   c-Myb   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFBP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGFBP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q36   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q33-q36

IGFBP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M217504:  view genomic region     (about GC identifiers)

Start:
217,536,828 bp from pter      End:
217,560,272 bp from pter
Size:
23,445 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 5 precursor  
Size: 272 amino acids; 30570 Da
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for IGFBP5:
1BOE (3D)        1H59 (3D)    
Secondary accessions: Q5U0A3

Explore the universe of human proteins at neXtProt for IGFBP5: NX_P24593

Explore proteomics data for IGFBP5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P24593

  • IGFBP5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGFBP5 Protein Expression
    REFSEQ proteins: NP_000590.1  
    ENSEMBL proteins: 
     ENSP00000233813   ENSP00000413474  
    Reactome Protein details: P24593
    Human Recombinant Protein Products for IGFBP5: 
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    Novus Biologicals IGFBP5 Proteins
    Novus Biologicals IGFBP5 Lysates
    Sino Biological Recombinant Protein for IGFBP5
    Sino Biological Cell Lysate for IGFBP5 
    ProSpec Recombinant Protein for IGFBP5
    Cloud-Clone Corp. Proteins for IGFBP5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0016942insulin-like growth factor binding protein complex IC10766744

    IGFBP5 for ontologies           About GeneDecksing



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    Assay Products for IGFBP5: 
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    GenScript Custom Assay Services for IGFBP5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IGFBP5 
    Cloud-Clone Corp. CLIAs for IGFBP5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR000716 Thyroglobulin_1
     IPR022321 IGFBP_1-6_chordata
     IPR000867 IGFBP-like
     IPR009168 IGFBP1-6
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry P24593

    ProtoNet protein and cluster: P24593

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB000867 Insulin-like growth factor-binding protein


    UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    IGFBP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBP5_HUMAN, P24593
    Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
    stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
    cell surface receptors

         Genatlas biochemistry entry for IGFBP5:
    insulin-like growth factor binding protein 5,high affinity,complexing with IGF1 and IGF2 and acid labile subunit
    expressed predominantly in kidney,fetal tissues,adult conective tissues and CSF,present in the serum but
    decreasing with age after puberty. Binding to bone cells (skeletal growth factor)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005515protein binding IPI15700281
    GO:0005520insulin-like growth factor binding ----
    GO:0031994insulin-like growth factor I binding IPI10766744
         
    IGFBP5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IGFBP5:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Igfbp5):
     adipose tissue  endocrine/exocrine gland  growth/size  homeostasis/metabolism  muscle 

    IGFBP5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Igfbp5tm1Jep for IGFBP5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGFBP5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGFBP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGFBP5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGFBP5 

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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGFBP5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    2Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Senescence and Autophagy
    Senescence and Autophagy
    5Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IGFBP5
        Development IGF-RI signaling


    1 GeneGo (Thomson Reuters) Pathway for IGFBP5
        Development IGF-1 receptor signaling

    2 BioSystems Pathways for IGFBP5
        Myometrial Relaxation and Contraction Pathways
    Senescence and Autophagy


    2        Reactome Pathways for IGFBP5
        Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Metabolism of proteins



    IGFBP5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGFBP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/27 Interacting proteins for IGFBP5 (P245932, 3 ENSP000002338134) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-63608 I2D: score=5 
    ENSG00000096155P463792, 3MINT-63608 I2D: score=5 
    ENSG00000227761P463792, 3MINT-63608 I2D: score=5 
    ENSG00000228760P463792, 3MINT-63608 I2D: score=5 
    ENSG00000229524P463792, 3MINT-63608 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0001649osteoblast differentiation IEA--
    GO:0006006glucose metabolic process IEA--
    GO:0007165signal transduction NAS7525452
    GO:0010906regulation of glucose metabolic process IEA--

    IGFBP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGFBP5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGFBP5 (IBP5)

    10/49 Novoseek inferred chemical compound relationships for IGFBP5 gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribonucleic acid 45.9 2 8855838 (1)
    eb 1089 45.8 5 10427145 (2)
    heparin 43 51 8626396 (6), 7538367 (3), 7519608 (3), 9374687 (3) (see all 18)
    estrogen 36.1 15 11054645 (2), 17675285 (2), 18373644 (1), 17555868 (1) (see all 9)
    procollagen 36 4 11054645 (1), 14517421 (1), 9700476 (1)
    1,25 dihydroxy vitamin d3 34.8 1 9199505 (1)
    serine 31.2 28 9528953 (3), 9838220 (2), 15534875 (2), 7523096 (2) (see all 12)
    heparan sulfate 28.2 1 9786878 (1)
    thymidine 26.1 4 10801263 (1), 8817658 (1), 8997222 (1), 11691647 (1)
    retinoic acid 25.2 30 8603611 (4), 15777798 (4), 9367833 (3), 17242174 (2) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about IGFBP5 / IBP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IGFBP5 gene: 
    NM_000599.3  

    Unigene Cluster for IGFBP5:

    Insulin-like growth factor binding protein 5
    Hs.607212  [show with all ESTs]
    Unigene Representative Sequence: NM_000599
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233813(uc002vgj.4) ENST00000486341 ENST00000449583
    miRNA
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    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP5 (see all 93):
    hsa-miR-411* hsa-miR-549 hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-193a-3p hsa-miR-642a hsa-miR-1321 hsa-miR-632
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    Additional mRNA sequence: 

    AF055033.1 AF147308.1 AK309609.1 AK314992.1 BC008099.1 BC011453.1 BC018427.1 BC032366.1 
    BC039838.1 BC046102.1 BC073984.1 BC089383.1 BC133664.1 BT019706.1 BT019707.1 CR456809.1 
    L27560.1 M62782.1 M65062.1 

    24/31 DOTS entries (see all 31):

    DT.75170481  DT.100705038  DT.100884425  DT.91728428  DT.100671612  DT.100697391  DT.120931735  DT.100884427 
    DT.97868293  DT.97775790  DT.120931724  DT.95305798  DT.102838850  DT.120931756  DT.95370309  DT.97793699 
    DT.120931741  DT.100672615  DT.100760287  DT.120931738  DT.120931755  DT.120931799  DT.120931832  DT.120931834 

    24/826 AceView cDNA sequences (see all 826):

    CA393965 AU121940 CD514994 AI591348 BQ018572 BX509382 F01379 AW057720 
    F37790 AI459753 CD671890 AI749976 BM805253 CD673295 BX506116 AI453681 
    BQ934318 AU131733 CA395418 CA392139 AI888622 BQ025930 BM663294 BM460793 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGFBP5 expression in normal human tissues (normalized intensities)      IGFBP5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAAGCATT
    IGFBP5 Expression
    About this image


    IGFBP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Brain (Nervous System)    fully expand to see all 23 entries
             Thalamus
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Human Cerebellar Astrocytes   
             Septum   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Human umbilical Smooth Muscle (HUSM)   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Retina
             Human Trabecular Meshwork Cells (HTMC)   
     
     Mesenchymal Stem Cells (Muscoskeletal System)    fully expand to see all 3 entries
             Decidua-derived mesenchymal cells
             Dental pulp Stem Cells (DPSC)   

    See IGFBP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGFBP5

    SOURCE GeneReport for Unigene cluster: Hs.607212

    UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593
    Tissue specificity: Osteosarcoma, and at lower levels in liver, kidney and brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including IGFBP5 (see all 7): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Prostate Cancer in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP5 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfbp51 , 5 insulin-like growth factor binding protein 51, 5 90.9(n)1
    94.83(a)1
      1 (36.94 cM)5
    160111  NM_010518.21  NP_034648.21 
     728579325 
    chicken
    (Gallus gallus)
    Aves IGFBP51 insulin-like growth factor binding protein 5 79.43(n)
    79.18(a)
      424220  XM_422069.3  XP_422069.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    96(a)
    79(a)
    1 ↔ many
    1 ↔ many
    1(90351267-90351419)
    GL343674.1(245029-248542)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52662 Xenopus laevis insulin-like growth factor binding protein more 78.19(n)    AY052629.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.249762 Danio rerio insulin-like growth factor binding protein more 77.9(n)    AY100478.1 


    ENSEMBL Gene Tree for IGFBP5 (if available)
    TreeFam Gene Tree for IGFBP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGFBP5 gene
    IGFBP22  IGFBP12  IGFBP62  IGFBP32  IGFBP42  
    2 SIMAP similar genes for IGFBP5 using alignment to 4 protein entries:     IBP5_HUMAN (see all proteins):
    IGFBP4    IGFBP3

    IGFBP5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/550 SNPs in IGFBP5 are shown (see all 550)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs46741071,2
    C,F,H--216919913(+) TTAAAA/CTCTTC 1 -- ds500125Minor allele frequency- C:0.22NA NS EA 2664
    rs764985711,2
    F--216920067(+) TTGGGG/CACATT 1 -- ds50011Minor allele frequency- C:0.02EA 120
    rs1402855741,2
    --216920092(+) TCACAA/GCAGCT 1 -- ds50010--------
    rs1503590091,2
    --216920115(+) ACCCAC/TAAGGA 1 -- ds50010--------
    rs1128028721,2
    C,F--216920135(+) CTGAGG/AAGGTT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs118949931,2
    C,F,A,H--216920153(+) TTGCCT/CTGGGT 1 -- ds500112Minor allele frequency- C:0.11NA NS EA WA CSA 785
    rs1437005431,2
    --216920163(+) TTCCAC/TGACTG 1 -- ds50010--------
    rs783676961,2
    C,F--216920190(+) GATGGG/CGAAGG 1 -- ds50011Minor allele frequency- C:0.09EA 120
    rs118893961,2
    C,F,H--216920262(+) GTGGCC/TGCTCA 1 -- ds50018Minor allele frequency- T:0.09NS EA WA NA CSA 533
    rs1132223531,2
    C,F--216920331(+) CAGGGG/ACTTGC 1 -- ds50011Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for IGFBP5 (217536828 - 217560272 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IGFBP5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522718CNV Loss19592680
    nsv460098CNV Loss19166990


    Human Gene Mutation Database (HGMD): IGFBP5
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGFBP5
    DNA2.0 Custom Variant and Variant Library Synthesis for IGFBP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 146734    OMIM disorders: --

    20/56 diseases for IGFBP5 (see all 56):    About MalaCards
    3-m syndrome    mn1    renal osteodystrophy    differentiating neuroblastoma
    estrogen-receptor positive breast cancer    acromegaly    papillary renal cell carcinoma    lung squamous cell carcinoma
    histiocytoma    fibrous histiocytoma    hyperparathyroidism    hyperthyroidism
    keratoconus    idiopathic pulmonary fibrosis    endometrial adenocarcinoma    goiter
    pulmonary fibrosis    osteosarcoma    neuroblastoma    prostate adenocarcinoma


    IGFBP5 for disorders           About GeneDecksing

    10/39 Novoseek inferred disease relationships for IGFBP5 gene (see all 39)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteosarcoma 47.2 16 16269403 (2), 18161051 (1), 7684391 (1), 11996908 (1) (see all 11)
    breast cancer 35.9 72 12777377 (6), 19341485 (5), 17651454 (5), 15802501 (4) (see all 22)
    breast carcinoma 27.6 6 18373644 (4), 9660801 (1), 1280130 (1)
    fibrosis idiopathic pulmonary 24.4 2 17071587 (1), 19628764 (1)
    renal osteodystrophy 18.1 2 10657717 (1), 10652019 (1)
    tumors 16.7 44 10850457 (3), 18775916 (3), 10218991 (3), 15618969 (2) (see all 21)
    prostate cancer 15.2 12 10850457 (4), 10830316 (2), 10218991 (1), 17823924 (1)
    glioblastoma 13.6 5 16700616 (1), 14515014 (1), 16619307 (1), 9213226 (1) (see all 5)
    bone loss 12.6 3 9795371 (2), 8817691 (1)
    bone diseases 11.8 1 10652019 (1)

    Genetic Association Database (GAD): IGFBP5
    Human Genome Epidemiology (HuGE) Navigator: IGFBP5 (19 documents)

    Export disorders for IGFBP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGFBP5 gene, integrated from 9 sources (see all 434):
    (articles sorted by number of sources associating them with IGFBP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. (PubMed id 7511611)1, 2, 3, 9 Allander S.V.... Powell D.R. (1994)
    2. Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. (PubMed id 18210156)1, 4, 9 Garner C.P....Neuhausen S.L. (2008)
    3. Genetic variation in insulin-like growth factor signa ling genes and breast cancer risk among BRCA1 and BRCA2 carriers. (PubMed id 19843326)1, 4, 9 Neuhausen S.L....Gillen D.L. (2009)
    4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    5. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    8. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    10. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolis m and breast cancer risk in the NCI breast and prostate cancer cohort consortiu m. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3488 HGNC: 5474 AceView: IGFBP5 Ensembl:ENSG00000115461 euGenes: HUgn3488
    ECgene: IGFBP5 H-InvDB: IGFBP5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGFBP5 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGFBP5 gene:
    Search GeneIP for patents involving IGFBP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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