IGFBP5 Gene

Aliases
for IGFBP5 gene

Previous GC identifers: GC02M215637 GC02M216262 GC02M217743 GC02M217362 GC02M217245 GC02M209391

Summaries
for IGFBP5 gene

Genomic Views
for IGFBP5 gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_005403.17  

SwitchGear Promoter luciferase reporter plasmid: IGFBP5 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP5

IGFBP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M217504:  view genomic region     (about GC identifiers)

Proteins
for IGFBP5 gene

2 PDB 3D structures from and Proteopedia for IGFBP5:

1BOE (3D)        1H59 (3D)    

Explore the universe of human proteins at neXtProt for IGFBP5: NX_P24593

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IGFBP5 (IGFBP-5)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IGFBP5 OriGene Custom Protein Services for IGFBP5
	GenScript Custom Purified and Recombinant Proteins Services for IGFBP5
	Novus Biologicals IGFBP5 Proteins Novus Biologicals IGFBP5 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IGFBP5
	Uscn Proteins for IGFBP5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IGFBP5
	R&D Systems Antibodies for IGFBP5 (IGFBP-5)
	Browse OriGene Antibodies OriGene Custom Antibody Services for IGFBP5
	GenScript Custom Superior Antibodies Services for IGFBP5
	Novus Biologicals IGFBP5 Antibodies
	Search for Antibodies for IGFBP5 at Abcam
	Uscn Antibodies for IGFBP5
	Search ThermoFisher Antibodies for IGFBP5

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IGFBP5 (IGFBP-5)
	GenScript Custom Assay Services for IGFBP5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IGFBP5

Protein Domains /
Families
for IGFBP5 gene

ProtoNet protein and cluster: P24593

Function
for IGFBP5 gene

miRNA Products:		OriGene 3'-UTR Clone: IGFBP5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBP5
		8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP5 (see all 93):
		hsa-miR-411* hsa-miR-549 hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-193a-3p hsa-miR-642a hsa-miR-1321 hsa-miR-632
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFBP5 (see all 7) OriGene shRNA RFP: IGFBP5 OriGene siRNA: IGFBP5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBP5

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for IGFBP5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP5 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IGFBP5 (NM_000599)
		Sino Biological Human cDNA Clone for IGFBP5
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBP5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGFBP5
		Search LifeMap BioReagents cell lines for IGFBP5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP5

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Igfbp5)

Pathways & Interactions
for IGFBP5 gene

	Super-pathway	contained gene-specific pathways
1	Development IGF-RI signaling	Development IGF-RI signaling 1.00 Development_IGF-1 receptor signaling 0.99
2	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 1.00
3	Senescence and Autophagy	Senescence and Autophagy 1.00
4	Calcium Regulation in the Cardiac Cell	Myometrial Relaxation and Contraction Pathways 0.43
5	Asparagine N-linked glycosylation	Metabolism of proteins 0.15

1 EMD Millipore Pathway for IGFBP5

Development IGF-RI signaling

1 GeneGo (Thomson Reuters) Pathway for IGFBP5

Development IGF-1 receptor signaling

2 BioSystems Pathways for IGFBP5

	Myometrial Relaxation and Contraction Pathways
	Senescence and Autophagy

2        Reactome Pathways for IGFBP5

	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	Metabolism of proteins

Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

Drugs & Compounds
for IGFBP5 gene

Transcripts
for IGFBP5 gene

Expression
for IGFBP5 gene

IGFBP5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAAAGCATT

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	HeartEndocardiumEndocardial Tube Cells			Endocardium
	OvaryAntral FollicleCumulus Cells			Ovary
	BrainHypothalamus			Brain
	BrainThalamus			Brain
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10 LifeMap Cells
	Name			Category
	PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)			Heart, Myocardium, Smooth Muscle
	PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
	PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
	PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
	PureStem™ progenitor W10 (Embryonic Progenitor Cell)
	Midbrain dopaminergic-like neurons (Generation of midbra...)
	Definitive endoderm-like cells (Generation of mesend...)
	Posterior foregut-like cells (A scalable, suspensi...)
	Epiblast-like cells (Reconstitution of mo...)
	Primordial germ cell-like cells (Reconstitution of mo...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGFBP5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IGFBP5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBP5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP5

Orthologs
for IGFBP5 gene

Paralogs
for IGFBP5 gene

Paralogs for IGFBP5 gene

IGFBP2²  IGFBP1²  IGFBP6²  IGFBP4²  IGFBP3²  

3 SIMAP similar genes for IGFBP5 using alignment to 4 protein entries:     IBP5_HUMAN (see all proteins):

IGFBP4    IGFBP3    IGFBP6

IGFBP5 for paralogs           About GeneDecksing

Genomic Variants
for IGFBP5 gene

10/502 NCBI SNPs in IGFBP5 are shown (see all 502)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs46741071,2	C,F,H,	--	217536354(+)	TTAAAA/CTCTTC	1	--	ds5001		25		NA NS EA	2664
rs764985711,2	F,	--	217536508(+)	TTGGGG/CACATT	1	--	ds5001		1		EA	120
rs1402855741,2		--	217536533(+)	TCACAA/GCAGCT	1	--	ds5001		0	--	--	--	--
rs1503590091,2		--	217536556(+)	ACCCAC/TAAGGA	1	--	ds5001		0	--	--	--	--
rs1128028721,2		--	217536576(+)	CTGAGG/AAGGTT	1	--	ds5001		1		CSA	2
rs118949931,2	C,F,A,H,	--	217536594(+)	TTGCCT/CTGGGT	1	--	ds5001		12		NA NS EA WA CSA	785
rs1437005431,2		--	217536604(+)	TTCCAC/TGACTG	1	--	ds5001		0	--	--	--	--
rs783676961,2	F,	--	217536631(+)	GATGGG/CGAAGG	1	--	ds5001		1		EA	120
rs118893961,2	C,F,H,	--	217536703(+)	GTGGCC/TGCTCA	1	--	ds5001		8		NS EA WA NA CSA	533
rs1132223531,2		--	217536772(+)	CAGGGG/ACTTGC	1	--	ds5001		1		CSA	2

HapMap Linkage Disequilibrium report for IGFBP5 (217536828 - 217560272 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for IGFBP5: --
Human Gene Mutation Database (HGMD): IGFBP5

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFBP5

DNA2.0 Custom Variant and Variant Library Synthesis for IGFBP5

Disorders / Diseases
for IGFBP5 gene

20/64 diseases for IGFBP5

10/39 Novoseek disease relationships for IGFBP5 gene (see all 39)    About this table

Publications
for IGFBP5 gene

PubMed articles for IGFBP5 gene, integrated from 9 sources (see all 428): (articles sorted by number of sources associating them with IGFBP5)

Utopia: connect your pdf to the dynamic world of online information

1. Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. (PubMed id 7511611)^{1, 2, 3, 9} Allander S.V.... Powell D.R. (1994)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions. (PubMed id 9822601)^{1, 2} Kalus W.... Holak T.A. (1998)
4. Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5. (PubMed id 9883900)^{1, 2} Standker L.... Forssmann W.-G. (1998)
5. Molecular cloning of a new human insulin-like growth factor binding protein. (PubMed id 1850258)^{1, 2} Kiefer M.C.... Zapf J. (1991)
6. Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human. (PubMed id 1709938)^{1, 2} Shimasaki S.... Ling N. (1991)
7. A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells. (PubMed id 1850257)^{1, 2} Andress D.L. and Birnbaum R.S. (1991)
8. The subcellular localization of IGFBP5 affects its cell growth and migration functions in breast cancer. (PubMed id 19341485)^{1, 9} Akkiprik M....Zhang W. (2009)
9. Fibronectin binds insulin-like growth factor-binding protein 5 and abolishes Its ligand-dependent action on cell migration. (PubMed id 14645245)^{1, 9} Xu Q....Duan C. (2004)
10. Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin. (PubMed id 9528953)^{1, 9} Zheng B....Clemmons D.R. (1998)

External Searches for IGFBP5 gene

Genome Databases showing IGFBP5 gene

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Specialized Databases showing IGFBP5 gene

Products
for IGFBP5 gene