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Aliases for IGFBP5 Gene

Aliases for IGFBP5 Gene

  • Insulin-Like Growth Factor Binding Protein 5 2 3
  • IBP5 3 4 6
  • IGF-Binding Protein 5 3 4
  • IGFBP-5 3 4
  • IBP-5 3 4
  • Insulin-Like Growth Factor-Binding Protein 5 3

External Ids for IGFBP5 Gene

Summaries for IGFBP5 Gene

GeneCards Summary for IGFBP5 Gene

IGFBP5 (Insulin-Like Growth Factor Binding Protein 5) is a Protein Coding gene. Diseases associated with IGFBP5 include insulin-like growth factor i and breast cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP4.

UniProtKB/Swiss-Prot for IGFBP5 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors

Gene Wiki entry for IGFBP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP5 Gene

Genomics for IGFBP5 Gene

Genomic Location for IGFBP5 Gene

Start:
216,672,105 bp from pter
End:
216,695,549 bp from pter
Size:
23,445 bases
Orientation:
Minus strand

Genomic View for IGFBP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGFBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP5 Gene

Regulatory Elements for IGFBP5 Gene

Proteins for IGFBP5 Gene

  • Protein details for IGFBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24593-IBP5_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 5
    Protein Accession:
    P24593
    Secondary Accessions:
    • Q5U0A3

    Protein attributes for IGFBP5 Gene

    Size:
    272 amino acids
    Molecular mass:
    30570 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IGFBP5 Gene

neXtProt entry for IGFBP5 Gene

Proteomics data for IGFBP5 Gene at MOPED

Post-translational modifications for IGFBP5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr123, Thr131, and Thr172

Other Protein References for IGFBP5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFBP5 Gene

Domains for IGFBP5 Gene

UniProtKB/Swiss-Prot:

IBP5_HUMAN
Domain:
  • Contains 1 IGFBP N-terminal domain.:
    • P24593
  • Contains 1 thyroglobulin type-1 domain.:
    • P24593
genes like me logo Genes that share domains with IGFBP5: view

No data available for Gene Families for IGFBP5 Gene

Function for IGFBP5 Gene

Molecular function for IGFBP5 Gene

GENATLAS Biochemistry: insulin-like growth factor binding protein 5,high affinity,complexing with IGF1 and IGF2 and acid labile subunit expressed predominantly in kidney,fetal tissues,adult conective tissues and CSF,present in the serum but decreasing with age after puberty. Binding to bone cells (skeletal growth factor)
UniProtKB/Swiss-Prot Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors

Gene Ontology (GO) - Molecular Function for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IBA --
GO:0005515 protein binding IPI 15700281
GO:0005520 insulin-like growth factor binding --
GO:0031994 insulin-like growth factor I binding IPI 10766744
GO:0031995 insulin-like growth factor II binding IBA --
genes like me logo Genes that share ontologies with IGFBP5: view
genes like me logo Genes that share phenotypes with IGFBP5: view

Animal Models for IGFBP5 Gene

MGI Knock Outs for IGFBP5:

miRNA for IGFBP5 Gene

miRTarBase miRNAs that target IGFBP5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IGFBP5 Gene

Localization for IGFBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFBP5 Gene COMPARTMENTS Subcellular localization image for IGFBP5 gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0016942 insulin-like growth factor binding protein complex IC 10766744
genes like me logo Genes that share ontologies with IGFBP5: view

Pathways for IGFBP5 Gene

genes like me logo Genes that share pathways with IGFBP5: view

Pathways by source for IGFBP5 Gene

Gene Ontology (GO) - Biological Process for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0006006 glucose metabolic process IEA --
GO:0007165 signal transduction NAS 7525452
GO:0010906 regulation of glucose metabolic process IEA --
genes like me logo Genes that share ontologies with IGFBP5: view

Compounds for IGFBP5 Gene

(49) Novoseek inferred chemical compound relationships for IGFBP5 Gene

Compound -log(P) Hits PubMed IDs
ribonucleic acid 45.9 1
eb 1089 45.8 2
heparin 43 31
estrogen 36.1 11
procollagen 36 3
genes like me logo Genes that share compounds with IGFBP5: view

Transcripts for IGFBP5 Gene

mRNA/cDNA for IGFBP5 Gene

Unigene Clusters for IGFBP5 Gene

Insulin-like growth factor binding protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP5 Gene

No ASD Table

Relevant External Links for IGFBP5 Gene

GeneLoc Exon Structure for
IGFBP5
ECgene alternative splicing isoforms for
IGFBP5

Expression for IGFBP5 Gene

mRNA expression in normal human tissues for IGFBP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBP5 Gene

This gene is overexpressed in Ovary (5.9) and Fallopian Tube (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IGFBP5 Gene

SOURCE GeneReport for Unigene cluster for IGFBP5 Gene Hs.607212

mRNA Expression by UniProt/SwissProt for IGFBP5 Gene

P24593-IBP5_HUMAN
Tissue specificity: Osteosarcoma, and at lower levels in liver, kidney and brain
genes like me logo Genes that share expressions with IGFBP5: view

Orthologs for IGFBP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBP5 36
  • 99.75 (n)
  • 99.63 (a)
IGFBP5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGFBP5 36
  • 95.54 (n)
  • 98.43 (a)
IGFBP5 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGFBP5 36
  • 95.87 (n)
  • 98.84 (a)
IGFBP5 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igfbp5 36
  • 91.47 (n)
  • 96.85 (a)
Igfbp5 16
Igfbp5 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFBP5 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP5 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igfbp5 36
  • 91.21 (n)
  • 96.46 (a)
chicken
(Gallus gallus)
Aves IGFBP5 36
  • 80.61 (n)
  • 82.47 (a)
IGFBP5 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGFBP5 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5266 36
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbp5 36
  • 75.63 (n)
  • 75.27 (a)
Str.15961 36
zebrafish
(Danio rerio)
Actinopterygii Dr.24976 36
igfbp5a 36
  • 64.08 (n)
  • 57.14 (a)
igfbp5a 37
  • 47 (a)
OneToMany
igfbp5b 37
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
OneToMany
Species with no ortholog for IGFBP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP5 Gene

ENSEMBL:
Gene Tree for IGFBP5 (if available)
TreeFam:
Gene Tree for IGFBP5 (if available)

Paralogs for IGFBP5 Gene

Paralogs for IGFBP5 Gene

Selected SIMAP similar genes for IGFBP5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IGFBP5: view

Variants for IGFBP5 Gene

Sequence variations from dbSNP and Humsavar for IGFBP5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3276 -- 216,672,275(+) TAAAC(A/G)GGAGC utr-variant-3-prime
rs12716 -- 216,672,531(+) AAAGA(A/C)AAAGA utr-variant-3-prime
rs722324 -- 216,679,512(-) TTCCC(A/G)GGTTC intron-variant
rs729596 -- 216,684,358(-) CCCAG(A/G)AACAG intron-variant
rs729597 -- 216,684,359(-) GCCCA(A/G)GAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFBP5 Gene

Variant ID Type Subtype PubMed ID
nsv460098 CNV Loss 19166990
nsv522718 CNV Loss 19592680

Relevant External Links for IGFBP5 Gene

HapMap Linkage Disequilibrium report
IGFBP5
Human Gene Mutation Database (HGMD)
IGFBP5

Disorders for IGFBP5 Gene

(39) Novoseek inferred disease relationships for IGFBP5 Gene

Disease -log(P) Hits PubMed IDs
osteosarcoma 47.2 12
breast cancer 35.9 49
breast carcinoma 27.6 6
fibrosis idiopathic pulmonary 24.4 2
renal osteodystrophy 18.1 2

Relevant External Links for IGFBP5

Genetic Association Database (GAD)
IGFBP5
Human Genome Epidemiology (HuGE) Navigator
IGFBP5
genes like me logo Genes that share disorders with IGFBP5: view

No data available for UniProtKB/Swiss-Prot for IGFBP5 Gene

Publications for IGFBP5 Gene

  1. Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. (PMID: 7511611) Allander S.V. … Powell D.R. (J. Biol. Chem. 1994) 2 3 4 23
  2. Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. (PMID: 18210156) Garner C.P. … Neuhausen S.L. (Hum. Genet. 2008) 3 23 49
  3. IGFBP2 and IGFBP5 overexpression correlates with the lymph node metastasis in T1 breast carcinomas. (PMID: 18373644) Wang H. … Sahin A.A. (Breast J 2008) 3 23
  4. Insulin-like growth factor binding protein-5 interacts with the vitamin D receptor and modulates the vitamin D response in osteoblasts. (PMID: 17595320) Schedlich L.J. … Baxter R.C. (Mol. Endocrinol. 2007) 3 23
  5. Expression level of insulin-like growth factor binding protein 5 mRNA is a prognostic factor for breast cancer. (PMID: 17651454) Li X. … Feng Y. (Cancer Sci. 2007) 3 23

Products for IGFBP5 Gene

Sources for IGFBP5 Gene

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