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IGFBP5 Gene

protein-coding GIFtS: 65

GC02M217245

insulin-like growth factor binding protein 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
IBP-5 ^³
IBP5 ^², ³, ⁵
IGFBP-5 ^³

Descriptions
IGF-binding protein 5 ^³
insulin-like growth factor binding protein 5 ^²

External Ids
HGNC: 5474¹
Entrez Gene: 3488²
UniProtKB: P24593³
Ensembl: ENSG00000115461⁷

Search outside databases for aliases for IGFBP5 gene

Previous GC identifers: GC02M215637 GC02M216262 GC02M217504 GC02M217743 GC02M217362

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either

inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the

interaction of IGFs with their cell surface receptors

Gene Wiki entry for IGFBP5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IGFBP5 gene

Entrez Gene cytogenetic band: 2q33-q36 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q33-q36

IGFBP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M217245: (about GC identifiers)

Start:	217,245,073 bp from pter
End:	217,268,516 bp from pter
Size:	23,444 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593 (See protein sequence)

Recommended Name: Insulin-like growth factor-binding protein 5 precursor

Size: 272 amino acids; 30570 Da

Subcellular location: Secreted

PDB structure from and Proteopedia :

1BOE (3D)

1H59 (3D)

Secondary accessions: Q5U0A3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000590.1

ENSEMBL proteins:

ENSP00000233813

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for IGFBP5
	R&D Systems Recombinant & Natural Proteins for IGFBP5 (IGFBP-5)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IGFBP5)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0016942	insulin-like growth factor binding protein complex	IC	10766744

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Antibodies for IGFBP5:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of IGFBP5
	Sigma-Aldrich Antibodies for IGFBP5
	R&D Systems Antibodies for IGFBP5 (IGFBP-5)
	Antibodies from Abcam (IGFBP5), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IGFBP5)
	Search Novus for antibodies for IGFBP5

Assays for IGFBP5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for IGFBP5 (IGFBP-5) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P24593

ProtoNet protein and cluster: P24593

2 Blocks protein families:

IPB000716 Thyroglobulin type-1

IPB000867 Insulin-like growth factor-binding protein

UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593

Similarity: Contains 1 IGFBP N-terminal domain

Similarity: Contains 1 thyroglobulin type-1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGFBP5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000599

Applied Biosystems Silencer® siRNAs for IGFBP5

Sigma-Aldrich siRNA for IGFBP5

Sigma-Aldrich shRNA for IGFBP5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IGFBP5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000599
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000599
untagged cDNA clones in CMV expression vector (see all 3): NM_000599

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000599

UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either

inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the

interaction of IGFs with their cell surface receptors

Genatlas biochemistry entry for IGFBP5:

insulin-like growth factor binding protein 5,high affinity,complexing with IGF1 and IGF2 and acid

labile subunit expressed predominantly in kidney,fetal tissues,adult conective tissues and

CSF,present in the serum but decreasing with age after puberty. Binding to bone cells (skeletal

growth factor)

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Igfbp5):

adipose tissue	digestive/alimentary	endocrine/exocrine gland	growth/size	homeostasis/metabolism
muscle

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0031994	insulin-like growth factor I binding	IPI	10766744

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for IGFBP5 (Your Favorite Gene powered by Ingenuity)

IGF-1 Signaling
VDR/RXR Activation
Hepatic Fibrosis / Hepatic Stellate Cell Activation

GeneDecks IGFBP5 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for IGFBP5

5/24 Interacting proteins for IGFBP5 (ENSP00000233813³ P24593²) via UniProtKB, MINT, and/or STRING (see all 24 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAT3	P46379²	MINT-63608
PNO1	Q9NRX1²	MINT-63609
IGF1	ENSP00000302665³	STRING (score=.999)
IGFALS	ENSP00000215539³	STRING (score=.998)
FHL2	ENSP00000344266³	STRING (score=.989)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0007165	signal transduction	NAS	7525452
GO:0014912	negative regulation of smooth muscle cell migration	IDA	10766744
GO:0017148	negative regulation of translation	IDA	15700281
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	IDA	10766744

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for IGFBP5

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IGFBP5
10/27 Novoseek chemical compound relationships for IGFBP5 gene (see all 27 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ribonucleic acid	47.15	2	8855838 (1)
procollagen	37.77	4	11054645 (1), 14517421 (1), 9700476 (1)
1,25 dihydroxy vitamin d3	36.13	1	9199505 (1)
heparan sulfate	30.13	1	9786878 (1)
mannose 6-phosphate	25.43	1	15642732 (1)
thymidine	24.90	4	10801263 (1), 8817658 (1), 8997222 (1), 11691647 (1)
progesterone	15.44	18	10473602 (6), 9462691 (2), 18373644 (1), 18497344 (1) (see all 7)
phosphatidylinositol	14.78	4	10830316 (1), 10601276 (1), 16619307 (1), 15068962 (1)
estradiol	11.81	5	16368782 (1), 1373605 (1), 12723086 (1), 8930399 (1)
forskolin	8.74	2	9462691 (1), 7534734 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGFBP5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000599

Sigma-Aldrich siRNA for IGFBP5

Sigma-Aldrich shRNA for IGFBP5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000599

REFSEQ mRNAs for IGFBP5 gene:

NM_000599.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000599

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000599
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000599
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000599

Additional cDNA sequence:

AF055033.1 AF147308.1 AK309609.1 AK314992.1 BC008099.1 BC011453.1 BC018427.1 BC032366.1

BC039838.1 BC046102.1 BC073984.1 BC089383.1 BC133664.1 BT019706.1 BT019707.1 CR456809.1

L27560.1 M62782.1 M65062.1

24/31 DOTS entries (see all 31 ):

DT.75170481 DT.100705038 DT.100884425 DT.91728428 DT.100671612 DT.100697391 DT.120931735 DT.100884427

DT.97868293 DT.97775790 DT.120931724 DT.95305798 DT.102838850 DT.120931756 DT.95370309 DT.97793699

DT.120931741 DT.100672615 DT.120931738 DT.120931755 DT.120931799 DT.120931832 DT.120931834 DT.40245280

24/826 AceView cDNA sequences (see all 826 ):

CO393416 BQ018572 AI564375 AL079792 CF131579 BM128680 CD514994 F09479

CF131348 BU145913 BC018427 AI589948 BE502399 CD678937 BM694479 BC073984

CD609118 AA086379 AI459753 BU739027 AI453681 CN481841 F01379 CA389138

highest scoring ESTs for IGFBP5:

AF055033 M65062 AA046381 AA298450 AA298593 AA369565 AA373088 AA374325 AA374965 AA376523

Unigene Cluster for IGFBP5:

Insulin-like growth factor binding protein 5

Hs.607212 [show with all ESTs]

Unigene Representative Sequence: NM_000599

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000233813

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IGFBP5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IGFBP5

¹ / ² / ³

19 probe-sets matching IGFBP5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38650_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.27	L27560	0.80	1.00	0.91	1
1396_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.22	L27560	0.80	1.00	0.91	1
1678_g_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.42	M65062	1.00	1.00	1.00	1
1601_s_at²^{, 3}	U95-A	1	1.00	1.00	0.84	0.24	L27559	0.20	1.00	0.72	1
1677_at²^{, 3}	U95-A	1	1.00	1.00	0.89	0.68	M65062	1.00	1.00	1.00	1
78056_s_at²^{, 3}	U95-E	1	1.00	1.00	0.92	1.53	AW022852	0.80	1.00	0.91	1
41420_at²^{, 3}	U95-A	1	1.00	1.00	0.88	0.45	AF055033	1.00	1.00	1.00	1
75124_s_at²^{, 3}	U95-D	1	1.00	1.00	0.95	1.57	AW007532	0.80	1.00	0.91	1
203426_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M65062	1.00	1.00	1.00	1
203424_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW157548	0.80	1.00	0.91	1
211959_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW007532	0.80	1.00	0.91	1
203425_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000599	0.60	1.00	0.82	1
211958_at²^{, 3}	U133-A	1	1.00	1.00	--	--	R73554	0.60	1.00	0.82	1
203426_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203424_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555997_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211959_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203425_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211958_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IGFBP5 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACAAAGCATT

SOURCE GeneReport for Unigene cluster: Hs.607212
Expression variation in blood from EXPOLDB for IGFBP5
UniProtKB/Swiss-Prot: IBP5_HUMAN, P24593
Tissue specificity: Osteosarcoma, and at lower levels in liver, kidney and brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for IGFBP5 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IGFBP5¹	--	insulin-like growth factor binding protein 5	95.69(n) 97.42(a)	610316 XM_847792.1 XP_852885.1
rat (Rattus norvegicus)	Igfbp5¹	--	insulin-like growth factor binding protein 5	90.77(n) 94.1(a)	25285 NM_012817.1 NP_036949.1
mouse (Mus musculus)	Igfbp5^{1, 5}	1 (36.10 cM)⁵	insulin-like growth factor binding protein 5^{1, 5}	91.02(n)¹ 94.83(a)¹	16011¹ NM_010518.2¹ NP_034648.2¹ AI256729⁵ AK011683⁵ (see all 26)
chicken (Gallus gallus)	IGFBP5¹	--	insulin-like growth factor binding protein 5	76.47(n) 78.82(a)	424220 XM_422069.2 XP_422069.2
zebrafish (Danio rerio)	Dr.24976²	--	Danio rerio insulin-like growth factor binding protein more	77.9(n)	AY100478.1

About this table Species with no ortholog for IGFBP5

ENSEMBL Gene Tree for IGFBP5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for IGFBP5 gene

IGFBP6² IGFBP3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/261 NCBI SNPs in IGFBP5 are shown (see all 261 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 161)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1978346^1,2	A,C,F,H,O	217269712(-)	`ATGGCC/TCACTC`	1	--	ng3¹		26	MN EU EA WA NA CSAM NS	2638
	rs3276^1,2	A,C,F,H,O	217245243(+)	`TAAACG/AGGAGC`	1	--	ut3¹ ese³		5	MN EU EA WA	602
	rs11894993^1,2	A,C,F,H	217244839(+)	`TTGCCT/CTGGGT`	1	--	ng5¹		6	NA EU EA	420
	rs1052946^1,2	A,C,F,H	217245613(-)	`CTCTCT/CACCGC`	1	--	ut3¹ ese³ trp³		5	MN EU EA WA	596
	rs7564880^1,2	A,C,F,H	217247206(+)	`AACAGT/CGACGT`	1	--	ut3¹ ese³		8	EU EA WA	838
	rs11575118^1,2	C,F,H	217269166(-)	`ACCTCT/ATCATC`	1	--	ng3¹		11	NS EU EA WA	1216
	rs11575211^1,2	C,F,H	217247884(-)	`CAGTCT/GAAACT`	1	--	ut3¹		10	NS EU EA WA NA CSAM	958
	rs4674107^1,2	C,F,H	217244599(+)	`TTAAAA/CTCTTC`	1	--	ng5¹		11	NA EU EA WA	936
	rs11575121^1,2	C,F,H	217268249(-)	`AACGCC/GTCTTA`	1	--	ut5¹ ese³		10	NS EU EA WA NA CSAM	974
	rs7596931^1,2	A,F,H	217245601(+)	`GGTGTG/AACAGT`	1	--	ut3¹ ese³		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for IGFBP5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 146734

10/38 Novoseek disease relationships for IGFBP5 gene (see all 38 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
osteosarcoma	49.01	16	16269403 (2), 18161051 (1), 7684391 (1), 11996908 (1) (see all 11)
breast cancer	33.93	64	12777377 (6), 19341485 (5), 17651454 (5), 15802501 (4) (see all 19)
breast carcinoma	29.42	6	18373644 (4), 9660801 (1), 1280130 (1)
renal osteodystrophy	19.66	2	10657717 (1), 10652019 (1)
fibrosis idiopathic pulmonary	17.94	1	17071587 (1)
glioblastoma	16.58	5	16700616 (1), 14515014 (1), 16619307 (1), 9213226 (1) (see all 5)
bone loss	15.02	3	9795371 (2), 8817691 (1)
prostate cancer	12.55	12	10850457 (4), 10830316 (2), 10218991 (1), 17823924 (1)
tumors	10.02	40	10850457 (3), 18775916 (3), 10218991 (3), 15618969 (2) (see all 19)
osteoarthritis	9.21	3	15308529 (2), 9564845 (1)

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Human Gene Mutation Database: IGFBP5
Genetic Association Database: IGFBP5
Human Genome Epidemiology Navigator: IGFBP5 (3 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/374 PubMed articles for IGFBP5 gene (see all 374 ):

Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. (PubMed id 7511611)^{1, 2, 3, 4} Allander S.V.... Powell D.R. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions. (PubMed id 9822601)^{3, 4} Kalus W.... Holak T.A. (1998)
Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5. (PubMed id 9883900)^{3, 4} Standker L.... Forssmann W.-G. (1998)
Molecular cloning of a new human insulin-like growth factor binding protein. (PubMed id 1850258)^{3, 4} Kiefer M.C.... Zapf J. (1991)
Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human. (PubMed id 1709938)^{3, 4} Shimasaki S.... Ling N. (1991)
A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells. (PubMed id 1850257)^{3, 4} Andress D.L. and Birnbaum R.S. (1991)
Fibronectin binds insulin-like growth factor-binding protein 5 and abolishes Its ligand-dependent action on cell migration. (PubMed id 14645245)^{1, 3} Xu Q....Duan C. (2004)
Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin. (PubMed id 9528953)^{1, 3} Zheng B....Clemmons D.R. (1998)
Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. (PubMed id 16007340)^{1, 3} Amaar Y.G....Mohan S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3488	HGNC: 5474	AceView: IGFBP5	Ensembl:ENSG00000115461	euGenes: HUgn3488
ECgene: IGFBP5	H-InvDB: IGFBP5

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/igfbp5/

Licensable Technologies for IGFBP5
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for IGFBP5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IGFBP5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IGFBP5		Antibodies for IGFBP5
	Explore super-pooled esiRNAs		Proteins for IGFBP5
	Lentivirus-delivered shRNAs for IGFBP5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (IGFBP5)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (IGFBP5)
	Antibodies (IGFBP5)

Search OriGene for IGFBP5

Search Tocris compounds for IGFBP5

	Drugs for IGFBP5
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for IGFBP5

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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IGFBP5 Gene at Home site.
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IGFBP5 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for IGFBP5

Summaries
for IGFBP5

Genomic Location
for IGFBP5

Proteins
for IGFBP5

Protein Domains/
Families
for IGFBP5

Gene Function
for IGFBP5

Pathways & Interactions
for IGFBP5

Drugs & Compounds
for IGFBP5

Transcripts
for IGFBP5

Expression
for IGFBP5

Orthologs
for IGFBP5

Paralogs
for IGFBP5

SNPs/Variants
for IGFBP5

Disorders & Mutations
for IGFBP5

Medical News
for IGFBP5

Publications
for IGFBP5

Search for IGFBP5

Genome Databases showing IGFBP5

Other Databases showing IGFBP5

Specialized Databases showing IGFBP5

Licensable Technologies
for IGFBP5

Services
for IGFBP5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IGFBP5 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor IGFBP5

Summariesfor IGFBP5

Genomic Locationfor IGFBP5

Proteinsfor IGFBP5

Protein Domains/Familiesfor IGFBP5

Gene Functionfor IGFBP5

Pathways & Interactionsfor IGFBP5

Drugs & Compoundsfor IGFBP5

Transcriptsfor IGFBP5

Expression for IGFBP5

Orthologsfor IGFBP5

Paralogsfor IGFBP5

SNPs/Variantsfor IGFBP5

Disorders & Mutationsfor IGFBP5

Medical Newsfor IGFBP5

Publicationsfor IGFBP5

Search for IGFBP5

Genome Databases showing IGFBP5

Other Databases showing IGFBP5

Specialized Databases showing IGFBP5

Licensable Technologiesfor IGFBP5

Servicesfor IGFBP5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IGFBP5

Summaries
for IGFBP5

Genomic Location
for IGFBP5

Proteins
for IGFBP5

Protein Domains/
Families
for IGFBP5

Gene Function
for IGFBP5

Pathways & Interactions
for IGFBP5

Drugs & Compounds
for IGFBP5

Transcripts
for IGFBP5

Expression
for IGFBP5

Orthologs
for IGFBP5

Paralogs
for IGFBP5

SNPs/Variants
for IGFBP5

Disorders & Mutations
for IGFBP5

Medical News
for IGFBP5

Publications
for IGFBP5

Licensable Technologies
for IGFBP5

Services
for IGFBP5