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Aliases for IGFBP4 Gene

Aliases for IGFBP4 Gene

  • Insulin Like Growth Factor Binding Protein 4 2 3 5
  • IGF-Binding Protein 4 2 3 4
  • Insulin-Like Growth Factor-Binding Protein 4 2 3
  • IGFBP-4 3 4
  • IBP-4 3 4
  • IBP4 3 4
  • Insulin-Like Growth Factor Binding Protein 4 2
  • HT29-IGFBP 3
  • BP-4 3

External Ids for IGFBP4 Gene

Previous GeneCards Identifiers for IGFBP4 Gene

  • GC17P038099
  • GC17P040775
  • GC17P038508
  • GC17P038972
  • GC17P035854
  • GC17P038599
  • GC17P034392

Summaries for IGFBP4 Gene

Entrez Gene Summary for IGFBP4 Gene

  • This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGFBP4 Gene

IGFBP4 (Insulin Like Growth Factor Binding Protein 4) is a Protein Coding gene. Diseases associated with IGFBP4 include Insulin-Like Growth Factor I and Renal Osteodystrophy. Among its related pathways are Wnt signaling network and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot for IGFBP4 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP4 Gene

Additional gene information for IGFBP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP4 Gene

Genomics for IGFBP4 Gene

Regulatory Elements for IGFBP4 Gene

Enhancers for IGFBP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H040528 2 FANTOM5 Ensembl ENCODE dbSUPER 22.4 +93.2 93183 15 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF766 SMARCE1 IGFBP4 RARA MED24 CCR7 SNORD124 LOC105371776 KRTAP9-2 TOP2A RPL23AP75
GH17H040478 2 FANTOM5 Ensembl ENCODE dbSUPER 15.8 +47.0 47035 24 PKNOX1 FOXA2 ZFP64 SIN3A FEZF1 YY1 ZNF143 FOS SP5 JUNB SNORD124 SMARCE1 MED24 IGFBP4 KRT10 RPL23AP75 TOP2A TNS4 RAPGEFL1 CDC6
GH17H040138 1.2 ENCODE 19.1 -303.1 -303086 3 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 MCM3 MEF2D MED1 SMARCE1 SNORD124 CDK12 MED24 MSL1 STARD3 IGFBP4 RPL19 THRA
GH17H040102 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -334.0 -333958 13 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 MCM3 NFYC MED1 CDK12 SMARCE1 MED24 MSL1 RPL19 SNORD124 RARA CASC3 THRA
GH17H040515 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +76.6 76647 9 FOXA2 ARNT SIN3A DMAP1 ZNF766 FOS SP5 SMARCB1 ZNF592 KAT8 SMARCE1 TOP2A SNORD124 MED24 CDC6 CCR7 IGFBP4 RPL23AP75 GJD3 RARA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGFBP4 on UCSC Golden Path with GeneCards custom track

Promoters for IGFBP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094094 876 2601 HDGF ZFP64 ARID4B SIN3A ZNF143 REST ZNF592 KAT8 SSRP1 MIER3

Genomic Location for IGFBP4 Gene

Chromosome:
17
Start:
40,443,424 bp from pter
End:
40,457,731 bp from pter
Size:
14,308 bases
Orientation:
Plus strand

Genomic View for IGFBP4 Gene

Genes around IGFBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP4 Gene

Proteins for IGFBP4 Gene

  • Protein details for IGFBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22692-IBP4_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 4
    Protein Accession:
    P22692
    Secondary Accessions:
    • A0N9W2
    • B4E351
    • Q5U012
    • Q9UCL6

    Protein attributes for IGFBP4 Gene

    Size:
    258 amino acids
    Molecular mass:
    27934 Da
    Quaternary structure:
    • Binds IGF2 more than IGF1.

    Three dimensional structures from OCA and Proteopedia for IGFBP4 Gene

    Alternative splice isoforms for IGFBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFBP4 Gene

Post-translational modifications for IGFBP4 Gene

  • Glycosylation at isoforms=2125 and isoforms=2173
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for IGFBP4

Protein Products

Assay Products

  • Abcam assays for IGFBP4

No data available for DME Specific Peptides for IGFBP4 Gene

Domains & Families for IGFBP4 Gene

Gene Families for IGFBP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFBP4: view

No data available for UniProtKB/Swiss-Prot for IGFBP4 Gene

Function for IGFBP4 Gene

Molecular function for IGFBP4 Gene

GENATLAS Biochemistry:
insulin-like growth factor binding protein 4 ,high affinity,functionnal antagonist of IGF1. Enhancer of apoptosis in malignant prostate cells
UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
UniProtKB/Swiss-Prot Induction:
By forskolin and N6,O2dibutyryl adenosine 3,5-cyclic monophosphate, but not by 1,9 dideoxyforskolin.

Phenotypes From GWAS Catalog for IGFBP4 Gene

Gene Ontology (GO) - Molecular Function for IGFBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 24431302
GO:0005520 insulin-like growth factor binding IEA --
GO:0019838 growth factor binding IEA --
GO:0031994 insulin-like growth factor I binding IBA --
GO:0031995 insulin-like growth factor II binding IBA --
genes like me logo Genes that share ontologies with IGFBP4: view
genes like me logo Genes that share phenotypes with IGFBP4: view

Animal Models for IGFBP4 Gene

MGI Knock Outs for IGFBP4:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFBP4

CRISPR Products

miRNA for IGFBP4 Gene

miRTarBase miRNAs that target IGFBP4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IGFBP4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP4 Gene

Localization for IGFBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP4 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGFBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with IGFBP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGFBP4 Gene

Pathways & Interactions for IGFBP4 Gene

genes like me logo Genes that share pathways with IGFBP4: view

Gene Ontology (GO) - Biological Process for IGFBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 1377672
GO:0001558 regulation of cell growth IEA --
GO:0006259 DNA metabolic process TAS 1377672
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS 1377672
genes like me logo Genes that share ontologies with IGFBP4: view

No data available for SIGNOR curated interactions for IGFBP4 Gene

Drugs & Compounds for IGFBP4 Gene

(26) Drugs for IGFBP4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for IGFBP4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP4: view

Transcripts for IGFBP4 Gene

mRNA/cDNA for IGFBP4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1457) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFBP4 Gene

Insulin-like growth factor binding protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IGFBP4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP4 Gene

No ASD Table

Relevant External Links for IGFBP4 Gene

GeneLoc Exon Structure for
IGFBP4
ECgene alternative splicing isoforms for
IGFBP4

Expression for IGFBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IGFBP4 Gene

This gene is overexpressed in Amniocyte (29.3), Serum (13.5), and Vitreous humor (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IGFBP4 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGFBP4 Gene:

IGFBP4

SOURCE GeneReport for Unigene cluster for IGFBP4 Gene:

Hs.462998

Evidence on tissue expression from TISSUES for IGFBP4 Gene

  • Intestine(4.7)
  • Liver(4.7)
  • Lung(4.7)
  • Stomach(4.7)
  • Nervous system(4.3)
  • Bone(3.2)
  • Kidney(3.2)
  • Eye(3.1)
  • Muscle(3)
  • Pancreas(3)
  • Thyroid gland(2.8)
  • Heart(2.5)
  • Gall bladder(2.4)
  • Skin(2.4)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with IGFBP4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP4 Gene

Orthologs for IGFBP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBP4 33 34
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia IGFBP4 33 34
  • 95.22 (n)
dog
(Canis familiaris)
Mammalia IGFBP4 33 34
  • 93.99 (n)
mouse
(Mus musculus)
Mammalia Igfbp4 33 16 34
  • 90 (n)
rat
(Rattus norvegicus)
Mammalia Igfbp4 33
  • 89.17 (n)
oppossum
(Monodelphis domestica)
Mammalia IGFBP4 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP4 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGFBP4 33 34
  • 79.13 (n)
lizard
(Anolis carolinensis)
Reptilia IGFBP4 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbp4 33
  • 63.19 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12229 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToMany
Species where no ortholog for IGFBP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFBP4 Gene

ENSEMBL:
Gene Tree for IGFBP4 (if available)
TreeFam:
Gene Tree for IGFBP4 (if available)

Paralogs for IGFBP4 Gene

Paralogs for IGFBP4 Gene

(4) SIMAP similar genes for IGFBP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IGFBP4: view

Variants for IGFBP4 Gene

Sequence variations from dbSNP and Humsavar for IGFBP4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000004900 -- 40,444,108(+) CCCAA(C/T)TCCCT intron-variant
rs1000041195 -- 40,445,720(+) TGGTA(A/G)AGGAG intron-variant
rs1000112456 -- 40,444,003(+) AGCCC(C/T)TGCAC reference, synonymous-codon
rs1000710890 -- 40,445,876(+) AGCAC(-/T)TTGAA intron-variant
rs1000983391 -- 40,450,422(+) GTGAT(C/T)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFBP4 Gene

Variant ID Type Subtype PubMed ID
nsv1144801 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv833445 CNV loss 17160897

Variation tolerance for IGFBP4 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFBP4 Gene

Human Gene Mutation Database (HGMD)
IGFBP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP4 Gene

Disorders for IGFBP4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IGFBP4 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
insulin-like growth factor i
  • insulin-like growth factor 1 resistance to
renal osteodystrophy
  • renal rickets
hereditary breast ovarian cancer
  • breast/ovarian cancer, hereditary
osteoporosis
  • osteoporosis, postmenopausal, susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGFBP4

Genetic Association Database (GAD)
IGFBP4
Human Genome Epidemiology (HuGE) Navigator
IGFBP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFBP4
genes like me logo Genes that share disorders with IGFBP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP4 Gene

Publications for IGFBP4 Gene

  1. Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation. (PMID: 1707125) LaTour D … Strong DD (Molecular endocrinology (Baltimore, Md.) 1990) 2 3 4 60
  2. Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human. (PMID: 1704481) Shimasaki S … Ling N (Molecular endocrinology (Baltimore, Md.) 1990) 2 3 4 60
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 45 60
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 45 60
  5. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (PMID: 20810604) Gu F … Kraft P (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60

Products for IGFBP4 Gene

Sources for IGFBP4 Gene

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