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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGFBP4 Gene

protein-coding   GIFtS: 64
GCID: GC17P038599

Insulin-Like Growth Factor Binding Protein 4

(Previous name: insulin-like growth factor-binding protein 4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin-Like Growth Factor Binding Protein 41 2     IBP42 3
IGF-Binding Protein 41 2 3     IGFBP-42 3
Insulin-Like Growth Factor-Binding Protein 41 2     BP-42
IBP-42 3     HT29-IGFBP2

External Ids:    HGNC: 54731   Entrez Gene: 34872   Ensembl: ENSG000001417537   OMIM: 1467335   UniProtKB: P226923   

Export aliases for IGFBP4 gene to outside databases

Previous GC identifers: GC17P038099 GC17P040775 GC17P038508 GC17P038972 GC17P035854 GC17P034392


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGFBP4 Gene:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with
an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I
and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein
prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. (provided by RefSeq,
Jul 2008)

GeneCards Summary for IGFBP4 Gene: 
IGFBP4 (insulin-like growth factor binding protein 4) is a protein-coding gene. Diseases associated with IGFBP4 include hereditary breast ovarian cancer, and renal osteodystrophy, and among its related super-pathways are Signal transduction AKT signaling and Non-Canonical Wnt Pathway. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot: IBP4_HUMAN, P22692
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
cell surface receptors

Gene Wiki entry for IGFBP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGFBP4 gene promoter:
         Pax-5   AML1a   Nkx2-5   GATA-1   GATA-2   Egr-4   Arnt   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFBP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGFBP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21.1   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q12-q21.1

IGFBP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P038599:  view genomic region     (about GC identifiers)

Start:
38,599,676 bp from pter      End:
38,613,983 bp from pter
Size:
14,308 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IBP4_HUMAN, P22692 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 4 precursor  
Size: 258 amino acids; 27934 Da
Subunit: Binds IGF2 more than IGF1
Subcellular location: Secreted
4 PDB 3D structures from and Proteopedia for IGFBP4:
1WQJ (3D)        2DSP (3D)        2DSQ (3D)        2DSR (3D)    
Secondary accessions: A0N9W2 Q5U012 Q9UCL6

Explore the universe of human proteins at neXtProt for IGFBP4: NX_P22692

Explore proteomics data for IGFBP4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22692

  • IGFBP4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGFBP4 Protein Expression
    REFSEQ proteins: NP_001543.2  
    ENSEMBL proteins: 
     ENSP00000269593   ENSP00000437734  
    Reactome Protein details: P22692
    Human Recombinant Protein Products for IGFBP4: 
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    Novus Biologicals IGFBP4 Protein
    Novus Biologicals IGFBP4 Lysates
    Sino Biological Recombinant Protein for IGFBP4
    Sino Biological Cell Lysate for IGFBP4 
    ProSpec Recombinant Protein for IGFBP4
    Cloud-Clone Corp. Proteins for IGFBP4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    IGFBP4 for ontologies           About GeneDecksing



    IGFBP4 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for IGFBP4 

    Assay Products for IGFBP4: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for IGFBP4 (IGFBP-4)
    GenScript Custom Assay Services for IGFBP4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IGFBP4 
    Cloud-Clone Corp. CLIAs for IGFBP4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR000716 Thyroglobulin_1
     IPR022327 IGFBP-4
     IPR022321 IGFBP_1-6_chordata
     IPR000867 IGFBP-like
     IPR009168 IGFBP1-6

    Graphical View of Domain Structure for InterPro Entry P22692

    ProtoNet protein and cluster: P22692

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB000867 Insulin-like growth factor-binding protein


    UniProtKB/Swiss-Prot: IBP4_HUMAN, P22692
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    IGFBP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBP4_HUMAN, P22692
    Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
    stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
    cell surface receptors
    Induction: By forskolin and N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate, but not by 1,9 dideoxyforskolin

         Genatlas biochemistry entry for IGFBP4:
    insulin-like growth factor binding protein 4 ,high affinity,functionnal antagonist of IGF1. Enhancer of apoptosis
    in malignant prostate cells

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005520insulin-like growth factor binding IEA--
         
    IGFBP4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IGFBP4:
     Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Igfbp4):
     adipose tissue  endocrine/exocrine gland  growth/size  homeostasis/metabolism  muscle 

    IGFBP4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Igfbp4tm1Jep for IGFBP4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGFBP4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGFBP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGFBP4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGFBP4 

    miRNA
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    hsa-miR-2052 hsa-miR-582-3p hsa-miR-4307 hsa-miR-19b-2* hsa-miR-3617 hsa-miR-548s hsa-miR-1285 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidIGFBP4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGFBP4 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    2Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    3Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for IGFBP4
        Cell adhesion ECM remodeling
    Development IGF-RI signaling


    2 GeneGo (Thomson Reuters) Pathways for IGFBP4
        Cell adhesion ECM remodeling
    Development IGF-1 receptor signaling

    2 BioSystems Pathways for IGFBP4
        Myometrial Relaxation and Contraction Pathways
    Wnt signaling network

    2 Sino Biological Pathways for IGFBP4 
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    2        Reactome Pathways for IGFBP4
        Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Metabolism of proteins



    IGFBP4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGFBP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for IGFBP4 (P226923 ENSP000002695934) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGF1P050193, ENSP000003026654I2D: score=4 STRING: ENSP00000302665
    CTSDP073393, ENSP000002366714I2D: score=2 STRING: ENSP00000236671
    IGF2P013443, ENSP000003382974I2D: score=2 STRING: ENSP00000338297
    PAPPAQ132193, ENSP000003306584I2D: score=1 STRING: ENSP00000330658
    TFP027873, ENSP000002649984I2D: score=2 STRING: ENSP00000264998
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS1377672
    GO:0001558regulation of cell growth IEA--
    GO:0006259DNA metabolic process TAS1377672
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction TAS1377672

    IGFBP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGFBP4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGFBP4 (IBP4)

    10/37 Novoseek inferred chemical compound relationships for IGFBP4 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribonucleic acid 56.8 12 7530254 (2), 9626114 (2), 8855838 (1), 11344229 (1) (see all 7)
    estrogen 43.6 22 7686749 (3), 11524170 (2), 17675285 (2), 10342835 (2) (see all 13)
    estradiol 40.9 11 17083925 (2), 9435457 (2), 8864746 (2), 16021855 (1) (see all 7)
    1,25 dihydroxy vitamin d3 40.6 5 8636339 (1), 7521341 (1)
    thymidine 36 10 7685579 (2), 10801263 (1), 11052994 (1), 7512304 (1) (see all 8)
    progesterone 31.6 10 11420230 (2), 9258879 (2), 7679899 (1), 7525978 (1) (see all 8)
    forskolin 31.4 10 10192430 (1), 7542953 (1), 9462691 (1), 7540852 (1) (see all 7)
    testosterone 28.7 12 11344229 (1), 7533776 (1), 11171591 (1), 7491931 (1) (see all 11)
    androstenedione 25.6 2 9435457 (1), 18381582 (1)
    actinomycin d 25 1 9795362 (1)

    Search CenterWatch for drugs/clinical trials and news about IGFBP4 / IBP4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IGFBP4 gene: 
    NM_001552.2  

    Unigene Cluster for IGFBP4:

    Insulin-like growth factor binding protein 4
    Hs.462998  [show with all ESTs]
    Unigene Representative Sequence: NM_001552
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269593(uc002hus.3) ENST00000542955
    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP4 (see all 15):
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP4

    Additional mRNA sequence: 

    AK290810.1 AK304572.1 BC016041.1 BT019891.1 BT019892.1 M38177.1 M62403.1 

    24/31 DOTS entries (see all 31):

    DT.95072547  DT.95104408  DT.40212779  DT.86859003  DT.120929456  DT.120929440  DT.120929436  DT.95151862 
    DT.100861434  DT.120929399  DT.120929398  DT.120929411  DT.100861435  DT.120929409  DT.100861432  DT.120929418 
    DT.120929422  DT.120929437  DT.120929442  DT.120929454  DT.120929457  DT.95151784  DT.95151852  DT.95151880 

    24/1457 AceView cDNA sequences (see all 1457):

    BU526780 AW338676 BU730343 BU957645 AI370038 AA476951 W56453 T47037 
    BM692572 CD518192 AI148611 T58980 AI623785 CN484482 AI569438 BI818414 
    CF131556 AA376249 AA485885 CA435019 CF130366 AI086833 BQ924533 F01780 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGFBP4 expression in normal human tissues (normalized intensities)      IGFBP4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTCTTTTC
    IGFBP4 Expression
    About this image


    IGFBP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 23 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             Human Brain Vascular Pericyte (HBVP)   
             Septum   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Human Annulus Fibrosus Cells (HAFC)   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Smooth Muscle (Muscoskeletal System)
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
     
     Hypoblast (Extraembryonic Tissues)
             Hypoblast Cells Hypoblast

    See IGFBP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGFBP4

    SOURCE GeneReport for Unigene cluster: Hs.462998
        SABiosciences Expression via Pathway-Focused PCR Arrays including IGFBP4: 
              Estrogen Receptor Signaling in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP4 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfbp41 , 5 insulin-like growth factor binding protein 41, 5 90.16(n)1
    92.13(a)1
      11 (62.92 cM)5
    160101  NM_010517.31  NP_034647.11 
     990412445 
    chicken
    (Gallus gallus)
    Aves IGFBP41 insulin-like growth factor binding protein 4 77.42(n)
    76.89(a)
      374271  NM_204353.1  NP_989684.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGFBP46
    Uncharacterized protein
    72(a)
    1 ↔ 1
    6(70118817-70172771)
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.122292 Oncorhynchus mykiss transcribed sequence with weak more 78(n)    BX887088.1 


    ENSEMBL Gene Tree for IGFBP4 (if available)
    TreeFam Gene Tree for IGFBP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGFBP4 gene
    IGFBP52  IGFBP22  IGFBP12  IGFBP62  IGFBP32  
    4 SIMAP similar genes for IGFBP4 using alignment to 2 protein entries:     IBP4_HUMAN (see all proteins):
    IGFBP5    IGFBP2    IGFBP1    IGFBP3

    IGFBP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/354 SNPs in IGFBP4 are shown (see all 354)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348436491,2
    C--34395434(+) TTCGT-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs356948241,2
    C,F--38597774(+) AATGCC/TACTCC 1 -- us2k16Minor allele frequency- T:0.00NA EU CSAM EA 382
    rs711526721,2
    C--38597923(-) GTCTC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1454103991,2
    --38598112(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1870875401,2
    --38598168(+) ATCTGA/CCCACC 1 -- us2k10--------
    rs1918837851,2
    --38598518(+) GGCGTA/GAGCCA 1 -- us2k10--------
    rs1476959621,2
    --38598802(+) CAAAAG/TTGCTG 1 -- us2k10--------
    rs1853145541,2
    --38598817(+) TACAGA/GTGTGA 1 -- us2k10--------
    rs357119051,2
    F--38598860(+) GCCATC/TTGGGA 1 -- us2k15Minor allele frequency- T:0.04NA EU CSAM EA 380
    rs1903413581,2
    --38598879(+) CAACAA/GCTCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IGFBP4 (38599676 - 38613983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IGFBP4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833445CNV Loss17160897
    nsv908223CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 146733    OMIM disorders: --

    20/39 diseases for IGFBP4 (see all 39):    About MalaCards
    hereditary breast ovarian cancer    renal osteodystrophy    follicular thyroid carcinoma    osteoporosis, postmenopausal
    hyperthyroidism    papillary renal cell carcinoma    rickets    polycystic ovary syndrome
    hyperparathyroidism    ovarian cancer    endometriosis    hypogonadism
    renal cell carcinoma    osteosarcoma    hypothyroidism    myopia
    colon cancer    diabetes mellitus    glioblastoma    lung adenocarcinoma


    IGFBP4 for disorders           About GeneDecksing

    10/35 Novoseek inferred disease relationships for IGFBP4 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteosarcoma 48.5 9 7534697 (2), 1283479 (1), 11996908 (1), 7506211 (1) (see all 6)
    renal osteodystrophy 31.9 2 10657717 (2)
    polycystic ovaries 30.7 1 9435457 (1)
    atresia 28.4 2 8530645 (1), 8949894 (1)
    bone loss 27.5 5 9795371 (2), 16397738 (1), 10652019 (1), 8817691 (1)
    colon cancer 21.9 15 8612513 (4), 8977421 (3), 15455346 (2), 16685432 (1) (see all 7)
    breast cancer 19.8 22 17287408 (4), 17675285 (4), 7525978 (3), 7686909 (1) (see all 6)
    growth retardation 17.6 2 12733722 (1), 11380497 (1)
    osteoporosis postmenopausal 15.9 1 8541319 (1)
    polycystic ovary syndrome 14 5 8886620 (2)

    Genetic Association Database (GAD): IGFBP4
    Human Genome Epidemiology (HuGE) Navigator: IGFBP4 (11 documents)

    Export disorders for IGFBP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGFBP4 gene, integrated from 9 sources (see all 405):
    (articles sorted by number of sources associating them with IGFBP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human. (PubMed id 1704481)1, 2, 3, 9 Shimasaki S.... Ling N. (1990)
    2. Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation. (PubMed id 1707125)1, 2, 3 Latour D.... Strong D.D. (1990)
    3. Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. (PubMed id 16924115)1, 2, 9 Sitar T.... Holak T.A. (2006)
    4. Pregnancy-associated plasma protein-A polymorphism and the risk of recurrent pregnancy loss. (PubMed id 16540175)1, 4, 9 Suzuki K....Kishi R. (2006)
    5. Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein. (PubMed id 1709585)1, 2, 9 Culouscou J.-M. and Shoyab M. (1991)
    6. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    7. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    8. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolis m and breast cancer risk in the NCI breast and prostate cancer cohort consortiu m. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (2010)
    9. Eighteen insulin-like growth factor pathway genes, ci rculating levels of IGF-I and its binding protein, and risk of prostate and bre ast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (2010)
    10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3487 HGNC: 5473 AceView: IGFBP4 Ensembl:ENSG00000141753 euGenes: HUgn3487
    ECgene: IGFBP4 H-InvDB: IGFBP4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGFBP4 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGFBP4 gene:
    Search GeneIP for patents involving IGFBP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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