Aliases for IGFBP4 Gene
External Ids for IGFBP4 Gene
Previous GeneCards Identifiers for IGFBP4 Gene
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for IGFBP4 Gene
IGFBP4 (Insulin Like Growth Factor Binding Protein 4) is a Protein Coding gene. Diseases associated with IGFBP4 include renal osteodystrophy and hereditary breast ovarian cancer. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways and Non-Canonical Wnt Pathway. GO annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP5.
UniProtKB/Swiss-Prot for IGFBP4 Gene
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.