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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGFBP4 Gene

protein-coding GIFtS: 61
GCID: GC17P038599

insulin-like growth factor binding protein 4

(Previous name: insulin-like growth factor-binding protein 4 )

Explore 46 diseases affiliated with
IGFBP4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Insulin-Like Growth Factor Binding Protein 4¹ ²		HT29-IGFBP¹ ²
IBP4¹ ² ³		Insulin-Like Growth Factor-Binding Protein 4¹ ²
IGFBP-4¹ ² ³		IBP-4² ³
BP-4¹ ²		IGF-Binding Protein 4² ³

External Ids:	HGNC: 5473¹	Entrez Gene: 3487²	Ensembl: ENSG00000141753⁷	OMIM: 146733⁵	UniProtKB: P22692³

Export aliases for IGFBP4 gene to outside databases

Previous GC identifers: GC17P038099 GC17P040775 GC17P038508 GC17P038972 GC17P035854 GC17P034392

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGFBP4:

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an

IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and

circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the

half-life of the IGFs and alters their interaction with cell surface receptors. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IBP4_HUMAN, P22692

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the

growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface

receptors

Gene Wiki entry for IGFBP4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGFBP4 gene promoter:
Pax-5 AML1a Nkx2-5 GATA-1 GATA-2 Egr-4 Arnt Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGFBP4 promoter sequence

Search SABiosciences Chromatin IP Primers for IGFBP4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21.1 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q12-q21.1

IGFBP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP4 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P038599: view genomic region (about GC identifiers)

Start:	38,599,676 bp from pter	End:	38,613,983 bp from pter
Size:	14,308 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IBP4_HUMAN, P22692 (See protein sequence)

Recommended Name: Insulin-like growth factor-binding protein 4 precursor

Size: 258 amino acids; 27934 Da

Subunit: Binds IGF2 more than IGF1

Subcellular location: Secreted

4 PDB 3D structures from and Proteopedia for IGFBP4:

1WQJ (3D)

2DSP (3D)

2DSQ (3D)

2DSR (3D)

Secondary accessions: A0N9W2 Q5U012 Q9UCL6

Explore the universe of human proteins at neXtProt for IGFBP4: NX_P22692

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P22692

IGFBP4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001543.2

ENSEMBL proteins:

ENSP00000269593 ENSP00000437734

Reactome Protein details: P22692
Human Recombinant Protein Products for IGFBP4:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals IGFBP4 Protein Novus Biologicals IGFBP4 Lysates
	Sino Biological Recombinant Protein for IGFBP4
	ProSpec Recombinant Protein for IGFBP4
	Uscn Proteins for IGFBP4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

IGFBP4 for ontologies About GeneDecksing

IGFBP4 Antibody Products:

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	Abcam antibodies for IGFBP4
	Uscn Antibodies for IGFBP4
	ThermoFisher Antibodies for IGFBP4

Assay Products for IGFBP4:

	Browse Kits and Assays available from EMD Millipore
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	R&D Systems ELISAs for IGFBP4 (IGFBP-4)
	GenScript Custom Assay Services for IGFBP4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IGFBP4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGFBP4 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000716 Thyroglobulin_1

IPR022327 IGFBP-4

IPR022321 IGFBP_1-6_chordata

IPR000867 IGFBP-like

IPR009168 IGFBP1-6

Graphical View of Domain Structure for InterPro Entry P22692

ProtoNet protein and cluster: P22692

2 Blocks protein families:

IPB000716 Thyroglobulin type-1

IPB000867 Insulin-like growth factor-binding protein

UniProtKB/Swiss-Prot: IBP4_HUMAN, P22692

Similarity: Contains 1 IGFBP N-terminal domain

Similarity: Contains 1 thyroglobulin type-1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IBP4_HUMAN, P22692

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the

growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface

receptors

Induction: By forskolin and N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate, but not by 1,9 dideoxyforskolin

Genatlas biochemistry entry for IGFBP4:

insulin-like growth factor binding protein 4 ,high affinity,functionnal antagonist of IGF1. Enhancer of apoptosis in

malignant prostate cells

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005520	insulin-like growth factor binding	IEA	--

IGFBP4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for IGFBP4:

Increased cell death HMECs cel

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Igfbp4):

adipose tissue

endocrine/exocrine gland

growth/size

homeostasis/metabolism

muscle

IGFBP4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Igfbp4^tm1Jep for IGFBP4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IGFBP4

miRNA Products:		OriGene 3'-UTR Clone: IGFBP4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBP4
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP4 (see all 15):
		hsa-miR-2052 hsa-miR-582-3p hsa-miR-4307 hsa-miR-19b-2* hsa-miR-3617 hsa-miR-548s hsa-miR-1285 hsa-miR-4314

		SwitchGear 3'UTR luciferase reporter plasmid: IGFBP4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFBP4 (see all 7) OriGene shRNA RFP: IGFBP4 OriGene siRNA: IGFBP4
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		Sirion Biotech Custom design and validation of potent shRNA sequences against IGFBP4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IGFBP4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IGFBP4 (NM_001552)
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		Sirion Biotech Customized stable knockdown cell line services for IGFBP4 Sirion Biotech Customized inducible knockdown cell line services for IGFBP4 Sirion Biotech Customized stable overexpressing cell line services for IGFBP4 Sirion Biotech Customized inducible overexpressing cell line services for IGFBP4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development IGF-RI signaling

Development IGF-RI signaling

1.00

Development_IGF-1 receptor signaling

0.99

Cell adhesion_ECM remodeling

Cell adhesion_ECM remodeling

1.00

Cell adhesion ECM remodeling

1.00

Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

1.00

Wnt signaling network

Wnt signaling network

1.00

Calcium Regulation in the Cardiac Cell

Myometrial Relaxation and Contraction Pathways

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for IGFBP4

	Cell adhesion ECM remodeling
	Development IGF-RI signaling

2 GeneGo (Thomson Reuters) Pathways for IGFBP4

	Cell adhesion ECM remodeling
	Development IGF-1 receptor signaling

2 BioSystems Pathways for IGFBP4

	Myometrial Relaxation and Contraction Pathways
	Wnt signaling network

2 Reactome Pathways for IGFBP4

	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	Metabolism of proteins

IGFBP4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IGFBP4

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/12 Interacting proteins for IGFBP4 (P22692³ ENSP00000269593⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGF1	P05019³, ENSP00000302665⁴	I2D: score=4 STRING: ENSP00000302665
CTSD	P07339³, ENSP00000236671⁴	I2D: score=2 STRING: ENSP00000236671
IGF2	P01344³, ENSP00000338297⁴	I2D: score=2 STRING: ENSP00000338297
PAPPA	Q13219³, ENSP00000330658⁴	I2D: score=1 STRING: ENSP00000330658
TF	P02787³, ENSP00000264998⁴	I2D: score=2 STRING: ENSP00000264998

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	1377672
GO:0001558	regulation of cell growth	IEA	--
GO:0006259	DNA metabolic process	TAS	1377672
GO:0006954	inflammatory response	IEA	--
GO:0007165	signal transduction	TAS	1377672

IGFBP4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IGFBP4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGFBP4
10/37 Novoseek chemical compound relationships for IGFBP4 gene (see all 37) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ribonucleic acid	56.8	12	7530254 (2), 9626114 (2), 8855838 (1), 11344229 (1) (see all 7)
estrogen	43.6	22	7686749 (3), 11524170 (2), 17675285 (2), 10342835 (2) (see all 13)
estradiol	40.9	11	17083925 (2), 9435457 (2), 8864746 (2), 16021855 (1) (see all 7)
1,25 dihydroxy vitamin d3	40.6	5	8636339 (1), 7521341 (1)
thymidine	36	10	7685579 (2), 10801263 (1), 11052994 (1), 7512304 (1) (see all 8)
progesterone	31.6	10	11420230 (2), 9258879 (2), 7679899 (1), 7525978 (1) (see all 8)
forskolin	31.4	10	10192430 (1), 7542953 (1), 9462691 (1), 7540852 (1) (see all 7)
testosterone	28.7	12	11344229 (1), 7533776 (1), 11171591 (1), 7491931 (1) (see all 11)
androstenedione	25.6	2	9435457 (1), 18381582 (1)
actinomycin d	25	1	9795362 (1)

Search CenterWatch for drugs/clinical trials and news about IGFBP4 / IBP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IGFBP4 gene:

NM_001552.2

Unigene Cluster for IGFBP4:

Insulin-like growth factor binding protein 4

Hs.462998 [show with all ESTs]

Unigene Representative Sequence: NM_001552

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000269593(uc002hus.3) ENST00000542955

miRNA Products:		OriGene 3'-UTR Clone: IGFBP4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBP4
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP4 (see all 15):
		hsa-miR-2052 hsa-miR-582-3p hsa-miR-4307 hsa-miR-19b-2* hsa-miR-3617 hsa-miR-548s hsa-miR-1285 hsa-miR-4314

		SwitchGear 3'UTR luciferase reporter plasmid: IGFBP4 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: IGFBP4 (NM_001552)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP4

Additional cDNA sequence:

AK290810.1 AK304572.1 BC016041.1 BT019891.1 BT019892.1 M38177.1 M62403.1

24/31 DOTS entries (see all 31):

DT.95072547 DT.95104408 DT.40212779 DT.86859003 DT.120929456 DT.120929440 DT.120929436 DT.95151862

DT.100861434 DT.120929399 DT.120929398 DT.120929411 DT.100861435 DT.120929409 DT.100861432 DT.120929418

DT.120929422 DT.120929437 DT.120929442 DT.120929454 DT.120929457 DT.95151784 DT.95151852 DT.95151880

24/1457 AceView cDNA sequences (see all 1457):

AA526060 T57625 BM662737 CA421402 CA422025 AW373234 BG939300 BM272958

AI951041 BU147324 BM792908 CF131395 CD251364 AA383278 BF724867 AI301606

BQ888745 BE049234 CD518192 R46322 T58189 AI913318 M62403 BE879557

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGFBP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTCTTTTC

About this image

IGFBP4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Choroid Plexus

Hypoblast

Hypoblast Cells

Extraembryonic Tissues

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IGFBP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGFBP4

SOURCE GeneReport for Unigene cluster: Hs.462998

SABiosciences Expression via Pathway-Focused PCR Arrays including IGFBP4:

Estrogen Receptor Signaling in human mouse rat

Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP4 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IGFBP4¹	insulin-like growth factor binding protein 4	77.42(n) 76.89(a)		374271 NM_204353.1 NP_989684.1
lizard (Anolis carolinensis)	Reptilia	IGFBP4⁶	--	72(a)	1 ↔ 1	6(70118817-70172771)
rainbow trout (Oncorhynchus mykiss)	Actinopterygii	Omy.12229²	Oncorhynchus mykiss transcribed sequence with weak more	78(n)		BX887088.1

ENSEMBL Gene Tree for IGFBP4 (if available)
TreeFam Gene Tree for IGFBP4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGFBP4 gene

IGFBP5² IGFBP2² IGFBP1² IGFBP6² IGFBP3²

4 SIMAP similar genes for IGFBP4 using alignment to 2 protein entries: IBP4_HUMAN (see all proteins):

IGFBP5 IGFBP2 IGFBP1 IGFBP3

IGFBP4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35694824^1,2	C	--	38597774(+)	`AATGCC/TACTCC`	1	--	us2k¹		6		NA EU CSAM EA	382
rs71152672^1,2	C	--	38597923(-)	`GTCTC-/AAAAAA`	1	--	us2k¹		1		NA	2
rs145410399^1,2		--	38598112(+)	`AGAGAC/TGGGGT`	1	--	us2k¹		0	--	--	--	--
rs187087540^1,2		--	38598168(+)	`ATCTGA/CCCACC`	1	--	us2k¹		0	--	--	--	--
rs191883785^1,2		--	38598518(+)	`GGCGTA/GAGCCA`	1	--	us2k¹		0	--	--	--	--
rs147695962^1,2		--	38598802(+)	`CAAAAG/TTGCTG`	1	--	us2k¹		0	--	--	--	--
rs185314554^1,2		--	38598817(+)	`TACAGA/GTGTGA`	1	--	us2k¹		0	--	--	--	--
rs35711905^1,2	F	--	38598860(+)	`GCCATC/TTGGGA`	1	--	us2k¹		5		NA EU CSAM EA	380
rs190341358^1,2		--	38598879(+)	`CAACAA/GCTCTA`	1	--	us2k¹		0	--	--	--	--
rs4641798^1,2	H	--	38598892(+)	`aatacA/Gcaatg`	1	--	us2k¹		4		NS EA	418

HapMap Linkage Disequilibrium report for IGFBP4 (38599676 - 38613983 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IGFBP4: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGFBP4 for disorders           About GeneDecksing

OMIM gene information: 146733    OMIM disorders: --

20/46 diseases for IGFBP4 (see all 46):    About MalaCards

osteoporosis, postmenopausal polycystic ovary syndrome renal osteodystrophy type 2 diabetes mellitus

breast-ovarian cancer diabetes mellitus papillary renal cell carcinoma hereditary breast ovarian cancer

renal cell carcinoma female breast cancer follicular thyroid carcinoma acute lymphoblastic leukemia

ovarian cancer lymphoblastic leukemia osteoporosis hyperthyroidism

hyperparathyroidism rickets nephropathy colon carcinoma

10/35 Novoseek disease relationships for IGFBP4 gene (see all 35) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteosarcoma	48.5	9	7534697 (2), 1283479 (1), 11996908 (1), 7506211 (1) (see all 6)
renal osteodystrophy	31.9	2	10657717 (2)
polycystic ovaries	30.7	1	9435457 (1)
atresia	28.4	2	8530645 (1), 8949894 (1)
bone loss	27.5	5	9795371 (2), 16397738 (1), 10652019 (1), 8817691 (1)
colon cancer	21.9	15	8612513 (4), 8977421 (3), 15455346 (2), 16685432 (1) (see all 7)
breast cancer	19.8	22	17287408 (4), 17675285 (4), 7525978 (3), 7686909 (1) (see all 6)
growth retardation	17.6	2	12733722 (1), 11380497 (1)
osteoporosis postmenopausal	15.9	1	8541319 (1)
polycystic ovary syndrome	14	5	8886620 (2)

Human Genome Epidemiology (HuGE) Navigator: IGFBP4 (11 documents)

Export disorders for IGFBP4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGFBP4 gene, integrated from 9 sources (see all 400):
(articles sorted by number of sources associating them with IGFBP4)

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Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human. (PubMed id 1704481)^{1, 2, 3, 9} Shimasaki S.... Ling N. (1990)
Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation. (PubMed id 1707125)^{1, 2, 3} Latour D.... Strong D.D. (1990)
Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. (PubMed id 16924115)^{1, 2, 9} Sitar T.... Holak T.A. (2006)
Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein. (PubMed id 1709585)^{1, 2, 9} Culouscou J.-M. and Shoyab M. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structure and transcription regulation of the human insulin-like growth factor binding protein 4 gene (IGFBP4). (PubMed id 9615225)^{1, 2} Zazzi H.... Luthman H. (1998)
Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum. (PubMed id 1709161)^{1, 2} Kiefer M.C.... Zapf J. (1991)
Biology of insulin-like growth factor binding protein-4 and its role in cancer (review). (PubMed id 16685432)^{1, 9} Durai R....Winslet M. (2006)
Insulin-like growth factor binding protein-4 interacts with centrosomes and microtubules in primary astrocytes. (PubMed id 15062981)^{1, 9} Chesik D....De Keyser J. (2004)
Studies on regulation of IGF (insulin-like growth factor)-binding protein (IGFBP) 4 proteolysis by pregnancy-associated plasma protein-A (PAPP-A) in cells treated with phorbol ester. (PubMed id 14705967)^{1, 9} Sivanandam A.S....Qin X. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3487	HGNC: 5473	AceView: IGFBP4	Ensembl:ENSG00000141753	euGenes: HUgn3487
ECgene: IGFBP4	H-InvDB: IGFBP4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IGFBP4	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/igfbp4/

Intellectual Property for IGFBP4 gene
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Patent Information for IGFBP4 gene:
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insulin-like growth factor binding protein 4

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IGFBP4 Gene

insulin-like growth factor binding protein 4

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