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IGFBP4 Gene

protein-coding   GIFtS: 65
GCID: GC17P038599

Insulin-Like Growth Factor Binding Protein 4

(Previous name: insulin-like growth factor-binding protein 4)
  See IGFBP4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin-Like Growth Factor Binding Protein 41 2     IBP42 3
IGF-Binding Protein 41 2 3     IGFBP-42 3
Insulin-Like Growth Factor-Binding Protein 41 2     BP-42
IBP-42 3     HT29-IGFBP2

External Ids:    HGNC: 54731   Entrez Gene: 34872   Ensembl: ENSG000001417537   OMIM: 1467335   UniProtKB: P226923   

Export aliases for IGFBP4 gene to outside databases

Previous GC identifers: GC17P038099 GC17P040775 GC17P038508 GC17P038972 GC17P035854 GC17P034392


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGFBP4 Gene:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with
an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I
and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein
prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. (provided by RefSeq,
Jul 2008)

GeneCards Summary for IGFBP4 Gene:
IGFBP4 (insulin-like growth factor binding protein 4) is a protein-coding gene. Diseases associated with IGFBP4 include follicular thyroid carcinoma, and ovarian cancer. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot: IBP4_HUMAN, P22692
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
cell surface receptors

Gene Wiki entry for IGFBP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGFBP4 gene promoter:
         Pax-5   AML1a   Nkx2-5   GATA-1   GATA-2   Egr-4   Arnt   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFBP4 promoter sequence
   Search Chromatin IP Primers for IGFBP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFBP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21.1   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q12-q21.1

IGFBP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P038599:  view genomic region     (about GC identifiers)

Start:
38,599,676 bp from pter      End:
38,613,983 bp from pter
Size:
14,308 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IBP4_HUMAN, P22692 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 4 precursor  
Size: 258 amino acids; 27934 Da
Subunit: Binds IGF2 more than IGF1
4 PDB 3D structures from and Proteopedia for IGFBP4:
1WQJ (3D)        2DSP (3D)        2DSQ (3D)        2DSR (3D)    
Secondary accessions: A0N9W2 Q5U012 Q9UCL6

Explore the universe of human proteins at neXtProt for IGFBP4: NX_P22692

Explore proteomics data for IGFBP4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn125, Ser173
  • Modification sites at PhosphoSitePlus

  • See IGFBP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001543.2  
    ENSEMBL proteins: 
     ENSP00000269593   ENSP00000437734  
    Reactome Protein details: P22692

    IGFBP4 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for IGFBP4
    ProSpec Recombinant Protein for IGFBP4
    Cloud-Clone Corp. Proteins for IGFBP4

     
    Search eBioscience for Proteins for IGFBP4 

     
    antibodies-online proteins for IGFBP4 (30 products) 

     
    antibodies-online peptides for IGFBP4

    IGFBP4 Antibody Products:

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    antibodies-online antibodies for IGFBP4 (78 products) 

    IGFBP4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for IGFBP4
    Cloud-Clone Corp. CLIAs for IGFBP4
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    antibodies-online kits for IGFBP4 (43 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR000716 Thyroglobulin_1
     IPR022327 IGFBP-4
     IPR022321 IGFBP_1-6_chordata
     IPR000867 IGFBP-like
     IPR009168 IGFBP1-6

    Graphical View of Domain Structure for InterPro Entry P22692

    ProtoNet protein and cluster: P22692

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB000867 Insulin-like growth factor-binding protein


    UniProtKB/Swiss-Prot: IBP4_HUMAN, P22692
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    Find genes that share domains with IGFBP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBP4_HUMAN, P22692
    Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
    stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
    cell surface receptors
    Induction: By forskolin and N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate, but not by 1,9 dideoxyforskolin

         Genatlas biochemistry entry for IGFBP4:
    insulin-like growth factor binding protein 4 ,high affinity,functionnal antagonist of IGF1. Enhancer of apoptosis
    in malignant prostate cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005520insulin-like growth factor binding IEA--
         
    Find genes that share ontologies with IGFBP4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IGFBP4:
     Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Igfbp4):
     adipose tissue  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  muscle 

    Find genes that share phenotypes with IGFBP4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Igfbp4tm1Jep for IGFBP4

       genOway: Develop your customized and physiologically relevant rodent model for IGFBP4

    miRNA
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    miRTarBase miRNAs that target IGFBP4:
    hsa-mir-7-5p (MIRT025735), hsa-mir-335-5p (MIRT017871), hsa-mir-124-3p (MIRT022691), hsa-mir-26b-5p (MIRT029547)

    Block miRNA regulation of human, mouse, rat IGFBP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGFBP4 (see all 15):
    hsa-miR-2052 hsa-miR-582-3p hsa-miR-4307 hsa-miR-19b-2* hsa-miR-3617 hsa-miR-548s hsa-miR-1285 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidIGFBP4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IGFBP4

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IBP4_HUMAN, P22692: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IGFBP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGFBP4 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    2Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    3Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    4Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with IGFBP4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for IGFBP4
        Cell adhesion ECM remodeling
    Development IGF-1 receptor signaling

    2 BioSystems Pathways for IGFBP4
        Myometrial Relaxation and Contraction Pathways
    Wnt signaling network

    2 Sino Biological Pathways for IGFBP4
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    1 Reactome Pathway for IGFBP4
        Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGFBP4: 
              Estrogen Receptor Signaling in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IGFBP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for IGFBP4 (P226923 ENSP000002695934) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGF1P050193, ENSP000003026654I2D: score=4 STRING: ENSP00000302665
    CTSDP073393, ENSP000002366714I2D: score=2 STRING: ENSP00000236671
    PAPPAQ132193, ENSP000003306584I2D: score=1 STRING: ENSP00000330658
    TFP027873, ENSP000002649984I2D: score=2 STRING: ENSP00000264998
    HK3P527903, ENSP000002924324I2D: score=3 STRING: ENSP00000292432
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS1377672
    GO:0001558regulation of cell growth IEA--
    GO:0006259DNA metabolic process TAS1377672
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction TAS1377672

    Find genes that share ontologies with IGFBP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGFBP4 (IBP4)

    Selected Novoseek inferred chemical compound relationships for IGFBP4 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribonucleic acid 56.8 12 7530254 (2), 9626114 (2), 8855838 (1), 11344229 (1) (see all 7)
    estrogen 43.6 22 7686749 (3), 11524170 (2), 17675285 (2), 10342835 (2) (see all 13)
    estradiol 40.9 11 17083925 (2), 9435457 (2), 8864746 (2), 16021855 (1) (see all 7)
    1,25 dihydroxy vitamin d3 40.6 5 8636339 (1), 7521341 (1)
    thymidine 36 10 7685579 (2), 10801263 (1), 11052994 (1), 7512304 (1) (see all 8)
    progesterone 31.6 10 11420230 (2), 9258879 (2), 7679899 (1), 7525978 (1) (see all 8)
    forskolin 31.4 10 10192430 (1), 7542953 (1), 9462691 (1), 7540852 (1) (see all 7)
    testosterone 28.7 12 11344229 (1), 7533776 (1), 11171591 (1), 7491931 (1) (see all 11)
    androstenedione 25.6 2 9435457 (1), 18381582 (1)
    actinomycin d 25 1 9795362 (1)



    Find genes that share compounds with IGFBP4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IGFBP4 gene: 
    NM_001552.2  

    Unigene Cluster for IGFBP4:

    Insulin-like growth factor binding protein 4
    Hs.462998  [show with all ESTs]
    Unigene Representative Sequence: NM_001552
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269593(uc002hus.3) ENST00000542955
    miRNA
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    hsa-miR-2052 hsa-miR-582-3p hsa-miR-4307 hsa-miR-19b-2* hsa-miR-3617 hsa-miR-548s hsa-miR-1285 hsa-miR-4314
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      QuantiFast Probe-based Assays in human, mouse, rat IGFBP4

    Additional mRNA sequence: 

    AK290810.1 AK304572.1 BC016041.1 BT019891.1 BT019892.1 M38177.1 M62403.1 

    Selected DOTS entries (see all 31):

    DT.95072547  DT.95104408  DT.40212779  DT.86859003  DT.120929456  DT.120929440  DT.120929436  DT.95151862 
    DT.100861434  DT.120929399  DT.120929398  DT.120929411  DT.100861435  DT.120929409  DT.100861432  DT.120929418 
    DT.120929422  DT.120929437  DT.120929442  DT.120929454  DT.120929457  DT.95151784  DT.95151852  DT.95151880 

    Selected AceView cDNA sequences (see all 1457):

    F01780 AA301850 AW006051 AW818776 CN483614 CA421402 R29299 BQ673564 
    AW373257 AW297241 BU148554 R47828 BQ924533 BG697852 CA435019 AW609950 
    CA422025 BM704848 T58980 BQ951154 CF129905 AW373234 AI094895 BG680644 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGFBP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTCTTTTC
    IGFBP4 Expression
    About this image


    IGFBP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Hypoblast (Extraembryonic Tissues)
             Hypoblast Cells Hypoblast
     
     Kidney (Urinary System)
             Renal Vesicle
     
     Heart (Cardiovascular System)
             Atrioventricular Node
    IGFBP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGFBP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.462998
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGFBP4: 
              Estrogen Receptor Signaling in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for IGFBP4
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    QuantiFast Probe-based Assays in human, mouse, rat IGFBP4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfbp41 , 5 insulin-like growth factor binding protein 41, 5 90(n)1
    92.5(a)1
      11 (62.92 cM)5
    160101  NM_010517.31  NP_034647.11 
     990412445 
    chicken
    (Gallus gallus)
    Aves IGFBP41 insulin-like growth factor binding protein 4 79.13(n)
    78.99(a)
      374271  NM_204353.1  NP_989684.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGFBP46
    insulin-like growth factor binding protein 4
    73(a)
    1 ↔ 1
    6(70118817-70172771)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia igfbp41 insulin-like growth factor binding protein 4 63.19(n)
    65.65(a)
      100498651  XM_002942584.2  XP_002942630.2 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.122292 Oncorhynchus mykiss transcribed sequence with weak more 78(n)    BX887088.1 


    ENSEMBL Gene Tree for IGFBP4 (if available)
    TreeFam Gene Tree for IGFBP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGFBP4 gene
    IGFBP52  IGFBP22  IGFBP12  IGFBP62  IGFBP32  
    4 SIMAP similar genes for IGFBP4 using alignment to 2 protein entries:     IBP4_HUMAN (see all proteins):
    IGFBP5    IGFBP2    IGFBP1    IGFBP3

    Find genes that share paralogs with IGFBP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGFBP4 (see all 354)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348436491,2
    C--34395434(+) TTCGT-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs356948241,2
    C,F--38597774(+) AATGCC/TACTCC 1 -- us2k16Minor allele frequency- T:0.00NA EU CSAM EA 382
    rs711526721,2
    C--38597923(-) GTCTC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1454103991,2
    --38598112(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1870875401,2
    --38598168(+) ATCTGA/CCCACC 1 -- us2k10--------
    rs1918837851,2
    --38598518(+) GGCGTA/GAGCCA 1 -- us2k10--------
    rs1476959621,2
    --38598802(+) CAAAAG/TTGCTG 1 -- us2k10--------
    rs1853145541,2
    --38598817(+) TACAGA/GTGTGA 1 -- us2k10--------
    rs357119051,2
    F--38598860(+) GCCATC/TTGGGA 1 -- us2k15Minor allele frequency- T:0.04NA EU CSAM EA 380
    rs1903413581,2
    --38598879(+) CAACAA/GCTCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IGFBP4 (38599676 - 38613983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IGFBP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833445CNV Loss17160897
    nsv908223CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IGFBP4
    DNA2.0 Custom Variant and Variant Library Synthesis for IGFBP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146733    OMIM disorders: --

    2 diseases for IGFBP4:    
    About MalaCards
    follicular thyroid carcinoma    ovarian cancer


    Find genes that share disorders with IGFBP4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IGFBP4 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteosarcoma 48.5 9 7534697 (2), 1283479 (1), 11996908 (1), 7506211 (1) (see all 6)
    renal osteodystrophy 31.9 2 10657717 (2)
    polycystic ovaries 30.7 1 9435457 (1)
    atresia 28.4 2 8530645 (1), 8949894 (1)
    bone loss 27.5 5 9795371 (2), 16397738 (1), 10652019 (1), 8817691 (1)
    colon cancer 21.9 15 8612513 (4), 8977421 (3), 15455346 (2), 16685432 (1) (see all 7)
    breast cancer 19.8 22 17287408 (4), 17675285 (4), 7525978 (3), 7686909 (1) (see all 6)
    growth retardation 17.6 2 12733722 (1), 11380497 (1)
    osteoporosis postmenopausal 15.9 1 8541319 (1)
    polycystic ovary syndrome 14 5 8886620 (2)

    Genetic Association Database (GAD): IGFBP4
    Human Genome Epidemiology (HuGE) Navigator: IGFBP4 (11 documents)

    Export disorders for IGFBP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGFBP4 gene, integrated from 10 sources (see all 406):
    (articles sorted by number of sources associating them with IGFBP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human. (PubMed id 1704481)1, 2, 3, 9 Shimasaki S.... Ling N. (Mol. Endocrinol. 1990)
    2. Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation. (PubMed id 1707125)1, 2, 3 Latour D.... Strong D.D. (Mol. Endocrinol. 1990)
    3. Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. (PubMed id 16924115)1, 2, 9 Sitar T.... Holak T.A. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    4. Pregnancy-associated plasma protein-A polymorphism and the risk of recurrent pregnancy loss. (PubMed id 16540175)1, 4, 9 Suzuki K....Kishi R. (J. Reprod. Immunol. 2006)
    5. Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein. (PubMed id 1709585)1, 2, 9 Culouscou J.-M. and Shoyab M. (Cancer Res. 1991)
    6. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    7. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    8. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    9. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (amp 2010)
    10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3487 HGNC: 5473 AceView: IGFBP4 Ensembl:ENSG00000141753 euGenes: HUgn3487
    ECgene: IGFBP4 H-InvDB: IGFBP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGFBP4 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGFBP4 gene:
    Search GeneIP for patents involving IGFBP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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