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IGFBP3 Gene

protein-coding   GIFtS: 70
GCID: GC07M045918

Insulin-Like Growth Factor Binding Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin-Like Growth Factor Binding Protein 31 2     IBP-32 3
IGF-Binding Protein 31 2 3     IBP32 3
Acid Stable Subunit Of The 140 K IGF Complex1 2     IGFBP-32 3
Binding Protein 291 2     BP-532
Binding Protein 531 2     Insulin-Like Growth Factor-Binding Protein 32
Growth Hormone-Dependent Binding Protein1 2     

External Ids:    HGNC: 54721   Entrez Gene: 34862   Ensembl: ENSG000001466747   OMIM: 1467325   UniProtKB: P179363   

Export aliases for IGFBP3 gene to outside databases

Previous GC identifers: GC07M045598 GC07M045692 GC07M045725 GC07M045836


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGFBP3 Gene:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with
an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth
factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it
circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface
receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
(provided by RefSeq, Jul 2008)

GeneCards Summary for IGFBP3 Gene:
IGFBP3 (insulin-like growth factor binding protein 3) is a protein-coding gene. Diseases associated with IGFBP3 include malignant mesenchymal tumor, and acid-labile subunit deficiency. GO annotations related to this gene include insulin-like growth factor I binding and insulin-like growth factor binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its
receptor TMEM219/IGFBP-3R

Gene Wiki entry for IGFBP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGFBP3 gene promoter:
         TBP   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): IGFBP3 promoter sequence
   Search Chromatin IP Primers for IGFBP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFBP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13-p12   Ensembl cytogenetic band:  7p12.3   HGNC cytogenetic band: 7p13-p12

IGFBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M045918:  view genomic region     (about GC identifiers)

Start:
45,951,844 bp from pter      End:
45,961,473 bp from pter
Size:
9,630 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 45,991,173-46,000,198     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 3 precursor  
Size: 291 amino acids; 31674 Da
Subunit: Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to
150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219
Developmental stage: IGFBP3 levels are higher during extrauterine life and peak during puberty
Secondary accessions: A4D2F5 D3DVM0 Q2V509 Q6P1M6 Q9UCL4
Alternative splicing: 2 isoforms:  P17936-1   P17936-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for IGFBP3: NX_P17936

Explore proteomics data for IGFBP3 at MOPED

Post-translational modifications: 

  • Phosphorylation sites are present in the extracellular medium1
  • Glycosylation2 at Asn116, Asn136, Ser148, Ser151, Ser153, Ser155, Ser156, Thr157, Ser161, Ser192,
                                 Thr195, Asn199, Thr277
  • Modification sites at PhosphoSitePlus

  • See IGFBP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000589.2  NP_001013416.1  

    ENSEMBL proteins: 
     ENSP00000370476   ENSP00000275521   ENSP00000370473   ENSP00000390298   ENSP00000399116  
     ENSP00000389668  
    Reactome Protein details: P17936

    IGFBP3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IGFBP3 Protein
    R&D Systems Recombinant & Natural Proteins for IGFBP3 (IGFBP-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IGFBP3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IGFBP3
    GenScript Purified and Recombinant Proteins for IGFBP3
    Novus Biologicals IGFBP3 Proteins
    Novus Biologicals IGFBP3 Lysate
    Sino Biological Recombinant Protein for IGFBP3
    Sino Biological Cell Lysate for IGFBP3
    ProSpec Recombinant Protein for IGFBP3
    Cloud-Clone Corp. Proteins for IGFBP3

    IGFBP3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IGFBP3
    R&D Systems Antibodies for IGFBP3 (IGFBP-3)
    OriGene Antibodies for IGFBP3
    OriGene Custom Antibody Services for IGFBP3
    Novus Biologicals IGFBP3 Antibodies
    Abcam antibodies for IGFBP3
    Cloud-Clone Corp. Antibodies for IGFBP3
    ThermoFisher Antibodies for IGFBP3
    LSBio Antibodies in human, mouse, rat for IGFBP3

    IGFBP3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IGFBP3
    R&D Systems ELISAs for IGFBP3 (IGFBP-3)         (see all)
    GenScript Custom Assay Services for IGFBP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IGFBP3
    Cloud-Clone Corp. CLIAs for IGFBP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR000716 Thyroglobulin_1
     IPR022321 IGFBP_1-6_chordata
     IPR000867 IGFBP-like
     IPR009168 IGFBP1-6
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry P17936

    ProtoNet protein and cluster: P17936

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB000867 Insulin-like growth factor-binding protein


    UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936
    Domain: The thyroglobulin type-1 domain mediates interaction with HN
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    IGFBP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBP3_HUMAN, P17936
    Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
    stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
    cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its
    receptor TMEM219/IGFBP-3R
    Induction: Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth
    hormone, EGF and phorbol esters

         Genatlas biochemistry entry for IGFBP3:
    insulin-like growth factor binding protein 3,high affinity,expressed by liver and non hepatic tissues,principal
    serum IGFBP,complexing with IGF1,IGF2 and an acid labile subunit. Mainly regulated by GH. Regulator of cell
    somatic growth and cellular proliferation,either IGF dependent or IGF independent,parameter of GH activity in
    acromegalic patients

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005515protein binding IPI14561895
    GO:0005520insulin-like growth factor binding NAS12599210
    GO:0008160protein tyrosine phosphatase activator activity IDA11940579
    GO:0031994insulin-like growth factor I binding IPI10766744
         
    IGFBP3 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Igfbp3):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     liver/biliary system  muscle 

    IGFBP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Igfbp3tm1Jep for IGFBP3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGFBP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGFBP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGFBP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGFBP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target IGFBP3:
    hsa-mir-375 (MIRT019713), hsa-mir-124-3p (MIRT022363)

    Block miRNA regulation of human, mouse, rat IGFBP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGFBP3 (see all 30):
    hsa-miR-485-5p hsa-miR-448 hsa-miR-875-3p hsa-miR-575 hsa-miR-628-3p hsa-miR-340 hsa-miR-197 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidIGFBP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IGFBP3
    Predesigned siRNA for gene silencing in human, mouse, rat IGFBP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IGFBP3

    Clone
    Products:
         
    OriGene clones in human, mouse for IGFBP3 (see all 12)
    OriGene ORF clones in mouse, rat for IGFBP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IGFBP3 (NM_001013398)
    Sino Biological Human cDNA Clone for IGFBP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IGFBP3
    Browse ESI BIO Cell Lines and PureStem Progenitors for IGFBP3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IBP3_HUMAN, P17936: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    cytoskeleton1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA17119061
    GO:0005634nucleus IDA17434920
    GO:0016942insulin-like growth factor binding protein complex IC10766744

    IGFBP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGFBP3 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    2Translation Insulin regulation of translation
    Transcription Receptor mediated HIF regulation0.51
    3Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    4p53 signaling pathway
    p53 signaling pathway0.41
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for IGFBP3
        Transcription Receptor-mediated HIF regulation
    Development IGF-1 receptor signaling

    4 BioSystems Pathways for IGFBP3
        Myometrial Relaxation and Contraction Pathways
    Senescence and Autophagy
    Integrated Pancreatic Cancer Pathway
    Direct p53 effectors


    1 Reactome Pathway for IGFBP3
        Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

    1 PharmGKB Pathway for IGFBP3
        Celecoxib Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for IGFBP3):
        p53 signaling pathway
    Transcriptional misregulation in cancer


    IGFBP3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGFBP3 (see all 10): 
              mTOR Signaling in human mouse rat
              Nephrotoxicity in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IGFBP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IGFBP3 (P179362, 3 ENSP000003704734) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLA2Q141812, 3MINT-63523 I2D: score=5 
    GTF3C1Q127892, 3, ENSP000003485104MINT-63522 I2D: score=5 STRING: ENSP00000348510
    COL1A1P024523, ENSP000002259644I2D: score=3 STRING: ENSP00000225964
    FN1P027513, ENSP000003468394I2D: score=3 STRING: ENSP00000346839
    IGF1P050193, ENSP000003026654I2D: score=3 STRING: ENSP00000302665
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0001933negative regulation of protein phosphorylation IDA17591901
    GO:0006468protein phosphorylation IDA17434920
    GO:0006915apoptotic process IEA--
    GO:0008285negative regulation of cell proliferation IGI19258508

    IGFBP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGFBP3 (IBP3)

    1 DrugBank Compound for IGFBP3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Mecasermin-- 68562-41-4target--19627167 15777106 18363546

    Selected Novoseek inferred chemical compound relationships for IGFBP3 gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estradiol 65.8 141 7515764 (6), 9626134 (5), 8557625 (5), 14671165 (4) (see all 78)
    testosterone 65.2 264 18097534 (7), 16541420 (6), 14671165 (5), 16825320 (4) (see all 99)
    iplex 64.6 6 15777106 (2), 16610982 (1), 16548790 (1)
    c-peptide 63 75 14770423 (4), 11808715 (4), 11072255 (3), 17689128 (3) (see all 42)
    glucose 60.5 261 11248744 (4), 7533774 (4), 18565922 (4), 17487212 (4) (see all 99)
    dehydroepiandrosterone sulfate 60.2 49 9100552 (3), 12940521 (2), 11314741 (2), 10468952 (2) (see all 22)
    androstenedione 58.1 36 9166698 (3), 16103701 (3), 11831514 (2), 15511959 (2) (see all 22)
    estrogen 52.4 109 10524681 (4), 10843175 (4), 8768841 (3), 12629097 (3) (see all 49)
    pegvisomant 52.1 9 17289896 (3), 11527090 (1), 16720661 (1), 16269873 (1) (see all 5)
    octreotide 51.7 52 7535670 (5), 7534239 (3), 8543925 (2), 10806600 (2) (see all 23)



    IGFBP3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IGFBP3 gene (2 alternative transcripts): 
    NM_000598.4  NM_001013398.1  

    Unigene Cluster for IGFBP3:

    Insulin-like growth factor binding protein 3
    Hs.450230  [show with all ESTs]
    Unigene Representative Sequence: NM_001013398
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381086 ENST00000275521(uc003tnq.3 uc003tnr.3 uc003tns.3 uc003tnt.3)
    ENST00000460209 ENST00000381083 ENST00000428530 ENST00000417621 ENST00000448817
    ENST00000465642 ENST00000460477
    miRNA
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    Block miRNA regulation of human, mouse, rat IGFBP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGFBP3 (see all 30):
    hsa-miR-485-5p hsa-miR-448 hsa-miR-875-3p hsa-miR-575 hsa-miR-628-3p hsa-miR-340 hsa-miR-197 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidIGFBP3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IGFBP3
    Predesigned siRNA for gene silencing in human, mouse, rat IGFBP3
    Clone
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    OriGene ORF clones in mouse, rat for IGFBP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IGFBP3 (NM_001013398)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP3
    Primer
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    OriGene qPCR primer pairs and template standards for IGFBP3
    OriGene qSTAR qPCR primer pairs in human, mouse for IGFBP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IGFBP3
      QuantiTect SYBR Green Assays in human, mouse, rat IGFBP3
      QuantiFast Probe-based Assays in human, mouse, rat IGFBP3

    Additional mRNA sequence: 

    AF370418.1 AK055632.1 AK056274.1 AK075483.1 AK091706.1 AK091745.1 AK092447.1 AK095408.1 
    AK095864.1 AK095869.1 AK095900.1 AK095907.1 AK095974.1 AK095991.1 AK097201.1 AK122873.1 
    AK123735.1 AK125224.1 AK127537.1 AK129951.1 AK130884.1 AK297767.1 AK298143.1 AK315668.1 
    BC000013.2 BC018962.2 BC064987.1 DQ884396.1 DQ884397.1 DQ884398.1 M31159.1 S56205.1 
    X64875.1 

    Selected DOTS entries (see all 90):

    DT.100884556  DT.100884573  DT.102837268  DT.121120781  DT.100884575  DT.100884577  DT.121120613  DT.100884572 
    DT.92464402  DT.101985495  DT.86859956  DT.100884596  DT.100884603  DT.97769487  DT.121120710  DT.97816827 
    DT.92464401  DT.100045316  DT.95172120  DT.100884588  DT.101966637  DT.100849103  DT.100884547  DT.91937442 

    Selected AceView cDNA sequences (see all 1222):

    AW732507 BQ718858 AK125224 AL543289 BQ083990 AI090448 CA314121 BQ956482 
    R31911 BM723932 BM759133 AI086711 BM680559 BM782334 BM977566 AI018121 
    BQ026444 BP379099 BQ012620 BP335454 CB150227 BQ925106 BQ670242 AA377699 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP3 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ·
    SP1:                          -     -     -     -                             -     -                 -                                   -                     
    SP2:              -     -     -     -     -     -     -     -     -           -     -                 -                                   -                     
    SP3:                    -     -     -     -     -     -                       -     -                 -                                   -                     
    SP4:                                                                          -     -                 -                                   -                     
    SP5:                    -     -     -     -     -     -                       -     -                 -     -     -                       -                     

    ExUns: 9e ^ 10 ^ 11a · 11b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for IGFBP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGFBP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGAGGAAA
    IGFBP3 Expression
    About this image


    IGFBP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 25) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone marrow-derived mesenchymal stem cells
             HyStem+BMP4-induced E15 cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             N2/LSB/S/F8-induced cells
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Detroit 551
    IGFBP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGFBP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.450230

    UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936
    Tissue specificity: Expressed by most tissues. Present in plasma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGFBP3 (see all 10): 
              mTOR Signaling in human mouse rat
              Nephrotoxicity in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfbp31 , 5 insulin-like growth factor binding protein 31, 5 83.1(n)1
    81.72(a)1
      11 (4.75 cM)5
    160091  NM_008343.21  NP_032369.21 
     72060865 
    chicken
    (Gallus gallus)
    Aves IGFBP31 insulin-like growth factor binding protein 3 74.19(n)
    75.1(a)
      420790  NM_001101034.1  NP_001094504.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGFBP36
    insulin-like growth factor binding protein 3
    62(a)
    1 ↔ 1
    6(53876086-53907146)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125832 Danio rerio mRNA for insulin-like growth factor binding more 75.3(n)    AJ299410.1 


    ENSEMBL Gene Tree for IGFBP3 (if available)
    TreeFam Gene Tree for IGFBP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGFBP3 gene
    IGFBP52  IGFBP22  IGFBP12  IGFBP62  IGFBP42  
    3 SIMAP similar genes for IGFBP3 using alignment to 5 protein entries:     IBP3_HUMAN (see all proteins):
    IGFBP5    IGFBP2    IGFBP4

    IGFBP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGFBP3 (see all 268)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362804
    A colorectal cancer sample4--see VAR_0362802 R C mis40--------
    VAR_0362794
    A colorectal cancer sample4--see VAR_0362792 T M mis40--------
    rs1887963031,2
    --45928430(+) GAACCC/TCTTCT 2 -- ds50010--------
    rs1932915951,2
    --45928488(+) CAAAGA/CGGTAA 2 -- ds50010--------
    rs776401311,2
    F--45928550(+) CTGTGG/CATGGC 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1419538011,2
    --45928794(+) GTTATA/GAAGTT 2 -- ds50010--------
    rs2001997921,2
    --45928841(+) TTTAT-/TATAATAA
    AATAATTATTA
    TATAA
    2 -- ut310--------
    rs346631671,2
    F--45928859(-) TTATATAATAATTAT
    TTTATTATA
    /-
    AATAA
    4 -- ut31 cds15Minor allele frequency- -:0.06NS 164
    rs1838021501,2
    --45928860(+) TATTAC/TATAAT 2 -- ut310--------
    rs1457336661,2
    --45928867(+) TAATAA/CAATAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for IGFBP3 (45951844 - 45961473 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IGFBP3: --
    Human Gene Mutation Database (HGMD): IGFBP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IGFBP3
    DNA2.0 Custom Variant and Variant Library Synthesis for IGFBP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146732    OMIM disorders: --

    Selected diseases for IGFBP3 (see all 222):    
    About MalaCards
    malignant mesenchymal tumor    acid-labile subunit deficiency    marasmus    sotos syndrome
    empty sella syndrome    diffuse idiopathic skeletal hyperostosis    rabson-mendenhall syndrome    endemic goiter
    laron syndrome    turner syndrome    anovulation    meninges hemangiopericytoma
    myelomeningocele    gigantism    recessive dystrophic epidermolysis bullosa    short stature
    hyperostosis    growth hormone deficiency    acromegaly    central precocious puberty

    8 diseases from the University of Copenhagen DISEASES database for IGFBP3:
    Acromegaly     Prostate cancer     Breast cancer     Diabetes mellitus
    Hypoglycemia     Turner syndrome     Colorectal cancer     Hypopituitarism

    IGFBP3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for IGFBP3 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    laron syndrome 84.6 12 17350302 (3), 9437227 (2), 15751611 (1), 16403822 (1) (see all 9)
    growth hormone deficiency 82.1 64 10469014 (3), 9835431 (3), 7543832 (2), 7518726 (2) (see all 34)
    short stature 81.8 78 19381505 (3), 15679071 (3), 16820702 (2), 10932487 (2) (see all 51)
    growth failure 79.9 16 10359158 (2), 16507628 (2), 9186890 (1), 12405432 (1) (see all 11)
    acromegaly 74.7 118 7586626 (8), 9231047 (5), 10195375 (5), 7533774 (5) (see all 40)
    igf-i resistance 69.4 5 15476454 (1), 16311944 (1), 12153610 (1), 12917202 (1)
    growth retardation 67.9 34 11207641 (3), 17726072 (2), 8894649 (1), 9795360 (1) (see all 25)
    growth disorders 65.2 10 1700965 (2), 19494704 (1), 16462144 (1), 7951670 (1) (see all 6)
    prostate cancer 62.8 333 17404112 (6), 14674736 (6), 15356036 (6), 18097534 (5) (see all 99)
    breast cancer 61 511 19888649 (8), 8609661 (7), 10067859 (6), 17287408 (6) (see all 99)

    Genetic Association Database (GAD): IGFBP3
    Human Genome Epidemiology (HuGE) Navigator: IGFBP3 (144 documents)

    Export disorders for IGFBP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGFBP3 gene, integrated from 10 sources (see all 2311):
    (articles sorted by number of sources associating them with IGFBP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. (PubMed id 1695633)1, 2, 3, 9 Cubbage M.L.... Powell D.R. (J. Biol. Chem. 1990)
    2. Genetic and epigenetic variability in the gene for IGFBP-3 (IGFBP3): correlation with serum IGFBP-3 levels and growth in short children born small for gestational age. (PubMed id 18929499)1, 4, 9 van der Kaay D.C....Deal C.L. (amp 2009)
    3. IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 18596909)1, 4, 9 Patel A.V....Feigelson H.S. (PLoS ONE 2008)
    4. IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women. (PubMed id 19240240)1, 4, 9 D'Aloisio A.A....Baird D.D. (amp 2009)
    5. A polymorphic locus in the promoter region of the IGFBP3 gene is related to mammographic breast density. (PubMed id 15066922)1, 4, 9 Lai J.H....Narod S.A. (amp 2004)
    6. Single nucleotide polymorphisms of IGFBP-3 gene and lung cancer risk in a Korean population. (PubMed id 18450319)1, 4, 9 Han S.G....Kim Y.H. (Lung Cancer 2008)
    7. Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort. (PubMed id 17035411)1, 4, 9 Cheng I....Freedman M.L. (amp 2006)
    8. IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. (PubMed id 16306136)1, 4, 9 Al-Zahrani A....Dunning A.M. (Hum. Mol. Genet. 2006)
    9. Association between two functional polymorphisms of insulin-like growth factor binding protein 3 and colorectal cancer risk in a Chinese population. (PubMed id 19492232)1, 4, 9 Xiang H....Nie S.F. (J. Toxicol. Environ. Health Part A 2009)
    10. Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women. (PubMed id 15298948)1, 4, 9 Ren Z....Zheng W. (amp 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3486 HGNC: 5472 AceView: IGFBP3 Ensembl:ENSG00000146674 euGenes: HUgn3486
    ECgene: IGFBP3 Kegg: 3486 H-InvDB: IGFBP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IGFBP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGFBP3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp3/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IGFBP3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGFBP3 gene:
    Search GeneIP for patents involving IGFBP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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