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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGFBP3 Gene

protein-coding   GIFtS: 69
GCID: GC07M045918

Insulin-Like Growth Factor Binding Protein 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin-Like Growth Factor Binding Protein 31 2     IBP-32 3
IGF-Binding Protein 31 2 3     IBP32 3
Acid Stable Subunit Of The 140 K IGF Complex1 2     IGFBP-32 3
Binding Protein 291 2     BP-532
Binding Protein 531 2     Insulin-Like Growth Factor-Binding Protein 32
Growth Hormone-Dependent Binding Protein1 2     

External Ids:    HGNC: 54721   Entrez Gene: 34862   Ensembl: ENSG000001466747   OMIM: 1467325   UniProtKB: P179363   

Export aliases for IGFBP3 gene to outside databases

Previous GC identifers: GC07M045598 GC07M045692 GC07M045725 GC07M045836


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGFBP3 Gene:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with
an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth
factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it
circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface
receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
(provided by RefSeq, Jul 2008)

GeneCards Summary for IGFBP3 Gene: 
IGFBP3 (insulin-like growth factor binding protein 3) is a protein-coding gene. Diseases associated with IGFBP3 include malignant mesenchymal tumor, and acid-labile subunit deficiency, and among its related super-pathways are Signal transduction AKT signaling and Translation Insulin regulation of translation. GO annotations related to this gene include insulin-like growth factor I binding and insulin-like growth factor binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its
receptor TMEM219/IGFBP-3R

Gene Wiki entry for IGFBP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGFBP3 gene promoter:
         TBP   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): IGFBP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGFBP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13-p12   Ensembl cytogenetic band:  7p12.3   HGNC cytogenetic band: 7p13-p12

IGFBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M045918:  view genomic region     (about GC identifiers)

Start:
45,951,844 bp from pter      End:
45,961,473 bp from pter
Size:
9,630 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 45,991,173-46,000,198     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 3 precursor  
Size: 291 amino acids; 31674 Da
Subunit: Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to
150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219
Subcellular location: Secreted
Developmental stage: IGFBP3 levels are higher during extrauterine life and peak during puberty
Secondary accessions: A4D2F5 D3DVM0 Q2V509 Q6P1M6 Q9UCL4
Alternative splicing: 2 isoforms:  P17936-1   P17936-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for IGFBP3: NX_P17936

Explore proteomics data for IGFBP3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation sites are present in the extracellular medium
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17936

  • IGFBP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGFBP3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000589.2  NP_001013416.1  

    ENSEMBL proteins: 
     ENSP00000370476   ENSP00000275521   ENSP00000370473   ENSP00000390298   ENSP00000399116  
     ENSP00000389668  
    Reactome Protein details: P17936
    Human Recombinant Protein Products for IGFBP3: 
    EMD Millipore Purified and/or Recombinant IGFBP3 Protein
    R&D Systems Recombinant & Natural Proteins for IGFBP3 (IGFBP-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IGFBP3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IGFBP3
    GenScript Purified and Recombinant Proteins for IGFBP3
    Novus Biologicals IGFBP3 Proteins
    Novus Biologicals IGFBP3 Lysate
    Sino Biological Recombinant Protein for IGFBP3
    Sino Biological Cell Lysate for IGFBP3 
    ProSpec Recombinant Protein for IGFBP3
    Cloud-Clone Corp. Proteins for IGFBP3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA17119061
    GO:0005634nucleus IDA17434920
    GO:0016942insulin-like growth factor binding protein complex IC10766744

    IGFBP3 for ontologies           About GeneDecksing



    IGFBP3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IGFBP3
    R&D Systems Antibodies for IGFBP3 (IGFBP-3)
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    Abcam antibodies for IGFBP3
    Cloud-Clone Corp. Antibodies for IGFBP3 
    ThermoFisher Antibodies for IGFBP3
    LSBio Antibodies in human, mouse, rat for IGFBP3 

    Assay Products for IGFBP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IGFBP3
    R&D Systems ELISAs for IGFBP3 (IGFBP-3)         (see all)
    GenScript Custom Assay Services for IGFBP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IGFBP3 
    Cloud-Clone Corp. CLIAs for IGFBP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR000716 Thyroglobulin_1
     IPR022321 IGFBP_1-6_chordata
     IPR000867 IGFBP-like
     IPR009168 IGFBP1-6
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry P17936

    ProtoNet protein and cluster: P17936

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB000867 Insulin-like growth factor-binding protein


    UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936
    Domain: The thyroglobulin type-1 domain mediates interaction with HN
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    IGFBP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBP3_HUMAN, P17936
    Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
    stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
    cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its
    receptor TMEM219/IGFBP-3R
    Induction: Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth
    hormone, EGF and phorbol esters

         Genatlas biochemistry entry for IGFBP3:
    insulin-like growth factor binding protein 3,high affinity,expressed by liver and non hepatic tissues,principal
    serum IGFBP,complexing with IGF1,IGF2 and an acid labile subunit. Mainly regulated by GH. Regulator of cell
    somatic growth and cellular proliferation,either IGF dependent or IGF independent,parameter of GH activity in
    acromegalic patients

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005515protein binding IPI14561895
    GO:0005520insulin-like growth factor binding NAS12599210
    GO:0008160protein tyrosine phosphatase activator activity IDA11940579
    GO:0031994insulin-like growth factor I binding IPI10766744
         
    IGFBP3 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Igfbp3):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     liver/biliary system  muscle 

    IGFBP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Igfbp3tm1Jep for IGFBP3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGFBP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGFBP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGFBP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGFBP3 

    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP3 (see all 30):
    hsa-miR-485-5p hsa-miR-448 hsa-miR-875-3p hsa-miR-575 hsa-miR-628-3p hsa-miR-340 hsa-miR-197 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidIGFBP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IGFBP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBP3

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of IGFBP3

    Clone
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    OriGene ORF clones in mouse, rat for IGFBP3
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    GenScript: all cDNA clones in your preferred vector (see all 2): IGFBP3 (NM_001013398)
    Sino Biological Human cDNA Clone for IGFBP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP3
    Sirion Biotech Customized lentivirus for stable overexpression of IGFBP3 
                         Customized lentivirus expression plasmids for stable overexpression of IGFBP3 

    Cell Line
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    Search LifeMap BioReagents cell lines for IGFBP3
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGFBP3 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    2Translation Insulin regulation of translation
    Transcription Receptor-mediated HIF regulation0.51
    3Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    4p53 signaling pathway
    p53 signaling pathway0.41
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for IGFBP3
        Transcription Receptor-mediated HIF regulation
    Development IGF-RI signaling


    2 GeneGo (Thomson Reuters) Pathways for IGFBP3
        Transcription Receptor-mediated HIF regulation
    Development IGF-1 receptor signaling

    4 BioSystems Pathways for IGFBP3
        Myometrial Relaxation and Contraction Pathways
    Senescence and Autophagy
    Integrated Pancreatic Cancer Pathway
    Direct p53 effectors


    2        Reactome Pathways for IGFBP3
        Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Metabolism of proteins

    1 PharmGKB Pathway for IGFBP3
        Celecoxib Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for IGFBP3):
        p53 signaling pathway
    Transcriptional misregulation in cancer


    IGFBP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGFBP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for IGFBP3 (P179362, 3 ENSP000003704734) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLA2Q141812, 3MINT-63523 I2D: score=5 
    GTF3C1Q127892, 3, ENSP000003485104MINT-63522 I2D: score=5 STRING: ENSP00000348510
    COL1A1P024523, ENSP000002259644I2D: score=3 STRING: ENSP00000225964
    FN1P027513, ENSP000003468394I2D: score=3 STRING: ENSP00000346839
    IGF1P050193, ENSP000003026654I2D: score=3 STRING: ENSP00000302665
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0001933negative regulation of protein phosphorylation IDA17591901
    GO:0006468protein phosphorylation IDA17434920
    GO:0006915apoptotic process IEA--
    GO:0008285negative regulation of cell proliferation IGI19258508

    IGFBP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGFBP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGFBP3 (IBP3)

    1 DrugBank Compound for IGFBP3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Mecasermin-- 68562-41-4target--19627167 15777106 18363546

    10/133 Novoseek inferred chemical compound relationships for IGFBP3 gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estradiol 65.8 141 7515764 (6), 9626134 (5), 8557625 (5), 14671165 (4) (see all 78)
    testosterone 65.2 264 18097534 (7), 16541420 (6), 14671165 (5), 16825320 (4) (see all 99)
    iplex 64.6 6 15777106 (2), 16610982 (1), 16548790 (1)
    c-peptide 63 75 14770423 (4), 11808715 (4), 11072255 (3), 17689128 (3) (see all 42)
    glucose 60.5 261 11248744 (4), 7533774 (4), 18565922 (4), 17487212 (4) (see all 99)
    dehydroepiandrosterone sulfate 60.2 49 9100552 (3), 12940521 (2), 11314741 (2), 10468952 (2) (see all 22)
    androstenedione 58.1 36 9166698 (3), 16103701 (3), 11831514 (2), 15511959 (2) (see all 22)
    estrogen 52.4 109 10524681 (4), 10843175 (4), 8768841 (3), 12629097 (3) (see all 49)
    pegvisomant 52.1 9 17289896 (3), 11527090 (1), 16720661 (1), 16269873 (1) (see all 5)
    octreotide 51.7 52 7535670 (5), 7534239 (3), 8543925 (2), 10806600 (2) (see all 23)

    Search CenterWatch for drugs/clinical trials and news about IGFBP3 / IBP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IGFBP3 gene (2 alternative transcripts): 
    NM_000598.4  NM_001013398.1  

    Unigene Cluster for IGFBP3:

    Insulin-like growth factor binding protein 3
    Hs.450230  [show with all ESTs]
    Unigene Representative Sequence: NM_001013398
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381086 ENST00000275521(uc003tnq.3 uc003tnr.3 uc003tns.3 uc003tnt.3)
    ENST00000460209 ENST00000381083 ENST00000428530 ENST00000417621 ENST00000448817
    ENST00000465642 ENST00000460477

    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP3 (see all 30):
    hsa-miR-485-5p hsa-miR-448 hsa-miR-875-3p hsa-miR-575 hsa-miR-628-3p hsa-miR-340 hsa-miR-197 hsa-miR-449a
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP3
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP3

    Additional mRNA sequence: 

    AF370418.1 AK055632.1 AK056274.1 AK075483.1 AK091706.1 AK091745.1 AK092447.1 AK095408.1 
    AK095864.1 AK095869.1 AK095900.1 AK095907.1 AK095974.1 AK095991.1 AK097201.1 AK122873.1 
    AK123735.1 AK125224.1 AK127537.1 AK129951.1 AK130884.1 AK297767.1 AK298143.1 AK315668.1 
    BC000013.2 BC018962.2 BC064987.1 DQ884396.1 DQ884397.1 DQ884398.1 M31159.1 S56205.1 
    X64875.1 

    24/90 DOTS entries (see all 90):

    DT.100884556  DT.100884573  DT.102837268  DT.121120781  DT.100884575  DT.100884577  DT.121120613  DT.100884572 
    DT.92464402  DT.101985495  DT.86859956  DT.100884596  DT.100884603  DT.97769487  DT.121120710  DT.97816827 
    DT.92464401  DT.100045316  DT.95172120  DT.100884588  DT.101966637  DT.100849103  DT.100884547  DT.91937442 

    24/1222 AceView cDNA sequences (see all 1222):

    BQ673034 BM989637 AI288849 BM782334 BU146146 CR617495 CR605771 BU627417 
    CR604414 CB852884 BP375831 BQ669089 BU684881 CR595168 BQ012620 AI191817 
    CA446126 AI865795 BU185020 BX339780 AK127537 BQ675110 BE221677 BP376460 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP3 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ·
    SP1:                          -     -     -     -                             -     -                 -                                   -                     
    SP2:              -     -     -     -     -     -     -     -     -           -     -                 -                                   -                     
    SP3:                    -     -     -     -     -     -                       -     -                 -                                   -                     
    SP4:                                                                          -     -                 -                                   -                     
    SP5:                    -     -     -     -     -     -                       -     -                 -     -     -                       -                     

    ExUns: 9e ^ 10 ^ 11a · 11b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for IGFBP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGFBP3 expression in normal human tissues (normalized intensities)      IGFBP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGAGGAAA
    IGFBP3 Expression
    About this image


    IGFBP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
             Coronary Artery Smooth Muscle Cells (CASMC)   
             Cardiac Myocytes   
     
     Fibroblast
             Detroit 551
             X-gene Foreskin Fibroblasts   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Bone marrow-derived mesenchymal stem cells
             HyStem+BMP4-induced E15 cells
             Normal Human osteoblasts (NHOST)   
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Dermis (Integumentary System)    fully expand to see all 4 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
             BH2 Dermal Fibroblasts   

    See IGFBP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGFBP3

    SOURCE GeneReport for Unigene cluster: Hs.450230

    UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936
    Tissue specificity: Expressed by most tissues. Present in plasma

        SABiosciences Expression via Pathway-Focused PCR Arrays including IGFBP3 (see all 10): 
              mTOR Signaling in human mouse rat
              Nephrotoxicity in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP3 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfbp31 , 5 insulin-like growth factor binding protein 31, 5 83.33(n)1
    82.07(a)1
      11 (4.75 cM)5
    160091  NM_008343.21  NP_032369.21 
     72060865 
    chicken
    (Gallus gallus)
    Aves IGFBP31 insulin-like growth factor binding protein 3 72.64(n)
    72.4(a)
      420790  NM_001101034.1  NP_001094504.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGFBP36
    Uncharacterized protein
    60(a)
    1 ↔ 1
    6(53876086-53907146)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125832 Danio rerio mRNA for insulin-like growth factor binding more 75.3(n)    AJ299410.1 


    ENSEMBL Gene Tree for IGFBP3 (if available)
    TreeFam Gene Tree for IGFBP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGFBP3 gene
    IGFBP52  IGFBP22  IGFBP12  IGFBP62  IGFBP42  
    3 SIMAP similar genes for IGFBP3 using alignment to 5 protein entries:     IBP3_HUMAN (see all proteins):
    IGFBP5    IGFBP2    IGFBP4

    IGFBP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/268 SNPs in IGFBP3 are shown (see all 268)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362804
    A colorectal cancer sample4--see VAR_0362802 R C mis40--------
    VAR_0362794
    A colorectal cancer sample4--see VAR_0362792 T M mis40--------
    rs1887963031,2
    --45928430(+) GAACCC/TCTTCT 2 -- ds50010--------
    rs1932915951,2
    --45928488(+) CAAAGA/CGGTAA 2 -- ds50010--------
    rs776401311,2
    F--45928550(+) CTGTGG/CATGGC 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1419538011,2
    --45928794(+) GTTATA/GAAGTT 2 -- ds50010--------
    rs2001997921,2
    --45928841(+) TTTAT-/TATAATAA
    AATAATTATTA
    TATAA
    2 -- ut310--------
    rs346631671,2
    F--45928859(-) TTATATAATAATTAT
    TTTATTATA
    /-
    AATAA
    4 -- ut31 cds15Minor allele frequency- -:0.06NS 164
    rs1838021501,2
    --45928860(+) TATTAC/TATAAT 2 -- ut310--------
    rs1457336661,2
    --45928867(+) TAATAA/CAATAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for IGFBP3 (45951844 - 45961473 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IGFBP3: --

    Human Gene Mutation Database (HGMD): IGFBP3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IGFBP3
    DNA2.0 Custom Variant and Variant Library Synthesis for IGFBP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 146732    OMIM disorders: --

    20/212 diseases for IGFBP3 (see all 212):    About MalaCards
    malignant mesenchymal tumor    acid-labile subunit deficiency    sotos syndrome    diffuse idiopathic skeletal hyperostosis
    marasmus    empty sella syndrome    rabson-mendenhall syndrome    endemic goiter
    idiopathic short stature    laron syndrome    growth disorders    turner syndrome
    meninges hemangiopericytoma    myelomeningocele    anovulation    gigantism
    recessive dystrophic epidermolysis bullosa    acromegaly    hyperostosis    growth hormone deficiency

    8 diseases from the University of Copenhagen DISEASES database for IGFBP3:
    Acromegaly     Prostate cancer     Breast cancer     Diabetes mellitus
    Hypoglycemia     Turner syndrome     Colorectal cancer     Hypopituitarism

    IGFBP3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/98 Novoseek inferred disease relationships for IGFBP3 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    laron syndrome 84.6 12 17350302 (3), 9437227 (2), 15751611 (1), 16403822 (1) (see all 9)
    growth hormone deficiency 82.1 64 10469014 (3), 9835431 (3), 7543832 (2), 7518726 (2) (see all 34)
    short stature 81.8 78 19381505 (3), 15679071 (3), 16820702 (2), 10932487 (2) (see all 51)
    growth failure 79.9 16 10359158 (2), 16507628 (2), 9186890 (1), 12405432 (1) (see all 11)
    acromegaly 74.7 118 7586626 (8), 9231047 (5), 10195375 (5), 7533774 (5) (see all 40)
    igf-i resistance 69.4 5 15476454 (1), 16311944 (1), 12153610 (1), 12917202 (1)
    growth retardation 67.9 34 11207641 (3), 17726072 (2), 8894649 (1), 9795360 (1) (see all 25)
    growth disorders 65.2 10 1700965 (2), 19494704 (1), 16462144 (1), 7951670 (1) (see all 6)
    prostate cancer 62.8 333 17404112 (6), 14674736 (6), 15356036 (6), 18097534 (5) (see all 99)
    breast cancer 61 511 19888649 (8), 8609661 (7), 10067859 (6), 17287408 (6) (see all 99)

    Genetic Association Database (GAD): IGFBP3
    Human Genome Epidemiology (HuGE) Navigator: IGFBP3 (144 documents)

    Export disorders for IGFBP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGFBP3 gene, integrated from 9 sources (see all 2295):
    (articles sorted by number of sources associating them with IGFBP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. (PubMed id 1695633)1, 2, 3, 9 Cubbage M.L.... Powell D.R. (1990)
    2. Genetic and epigenetic variability in the gene for IGFBP-3 (IGFBP3): Correlation with serum IGFBP-3 levels and growth in short children born small for gestational age. (PubMed id 18929499)1, 4, 9 Kaay D.C....Deal C.L. (2008)
    3. IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 18596909)1, 4, 9 Patel A.V....Feigelson H.S. (2008)
    4. IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women. (PubMed id 19240240)1, 4, 9 D'Aloisio A.A....Baird D.D. (2009)
    5. A polymorphic locus in the promoter region of the IGFBP3 gene is related to mammographic breast density. (PubMed id 15066922)1, 4, 9 Lai J.H....Narod S.A. (2004)
    6. Single nucleotide polymorphisms of IGFBP-3 gene and lung cancer risk in a Korean population. (PubMed id 18450319)1, 4, 9 Han S.G....Kim Y.H. (2008)
    7. Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort. (PubMed id 17035411)1, 4, 9 Cheng I....Freedman M.L. (2006)
    8. IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. (PubMed id 16306136)1, 4, 9 Al-Zahrani A....Dunning A.M. (2006)
    9. Association between two functional polymorphisms of i nsulin-like growth factor binding protein 3 and colorectal cancer risk in a Chi nese population. (PubMed id 19492232)1, 4, 9 Xiang H....Nie S.F. (2009)
    10. Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women. (PubMed id 15298948)1, 4, 9 Ren Z....Zheng W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3486 HGNC: 5472 AceView: IGFBP3 Ensembl:ENSG00000146674 euGenes: HUgn3486
    ECgene: IGFBP3 Kegg: 3486 H-InvDB: IGFBP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGFBP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGFBP3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp3/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IGFBP3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGFBP3 gene:
    Search GeneIP for patents involving IGFBP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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