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Aliases for IGFBP3 Gene

Aliases for IGFBP3 Gene

  • Insulin-Like Growth Factor Binding Protein 3 2 3
  • IGF-Binding Protein 3 2 3 4
  • Acid Stable Subunit Of The 140 K IGF Complex 2 3
  • Growth Hormone-Dependent Binding Protein 2 3
  • Binding Protein 53 2 3
  • Binding Protein 29 2 3
  • IGFBP-3 3 4
  • IBP-3 3 4
  • IBP3 3 4
  • Insulin-Like Growth Factor-Binding Protein 3 3
  • BP-53 3

External Ids for IGFBP3 Gene

Previous GeneCards Identifiers for IGFBP3 Gene

  • GC07M045598
  • GC07M045692
  • GC07M045725
  • GC07M045918
  • GC07M045836

Summaries for IGFBP3 Gene

Entrez Gene Summary for IGFBP3 Gene

  • This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGFBP3 Gene

IGFBP3 (Insulin-Like Growth Factor Binding Protein 3) is a Protein Coding gene. Diseases associated with IGFBP3 include malignant mesenchymal tumor and marasmus. Among its related pathways are Integrated Pancreatic Cancer Pathway and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP4.

UniProtKB/Swiss-Prot for IGFBP3 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

Gene Wiki entry for IGFBP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP3 Gene

Genomics for IGFBP3 Gene

Regulatory Elements for IGFBP3 Gene

Transcription factor binding sites by QIAGEN in the IGFBP3 gene promoter:

Genomic Location for IGFBP3 Gene

Start:
45,912,245 bp from pter
End:
45,921,874 bp from pter
Size:
9,630 bases
Orientation:
Minus strand

Genomic View for IGFBP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGFBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP3 Gene

Proteins for IGFBP3 Gene

  • Protein details for IGFBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17936-IBP3_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 3
    Protein Accession:
    P17936
    Secondary Accessions:
    • A4D2F5
    • D3DVM0
    • Q2V509
    • Q6P1M6
    • Q9UCL4

    Protein attributes for IGFBP3 Gene

    Size:
    291 amino acids
    Molecular mass:
    31674 Da
    Quaternary structure:
    • Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219.

    Alternative splice isoforms for IGFBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFBP3 Gene

Proteomics data for IGFBP3 Gene at MOPED

Post-translational modifications for IGFBP3 Gene

  • Phosphorylation sites are present in the extracellular medium
  • Glycosylation at Asn116, Asn136, Ser148, Ser151, Ser153, Ser155, Ser156, Thr157, Ser161, Ser192, Thr195, Asn199, and Thr277
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBP3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IGFBP3 (IGFBP3)

Protein Products

No data available for DME Specific Peptides for IGFBP3 Gene

Domains for IGFBP3 Gene

Graphical View of Domain Structure for InterPro Entry

P17936

UniProtKB/Swiss-Prot:

IBP3_HUMAN :
  • P17936
Domain:
  • The thyroglobulin type-1 domain mediates interaction with HN
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with IGFBP3: view

No data available for Gene Families for IGFBP3 Gene

Function for IGFBP3 Gene

Molecular function for IGFBP3 Gene

GENATLAS Biochemistry: insulin-like growth factor binding protein 3,high affinity,expressed by liver and non hepatic tissues,principal serum IGFBP,complexing with IGF1,IGF2 and an acid labile subunit. Mainly regulated by GH. Regulator of cell somatic growth and cellular proliferation,either IGF dependent or IGF independent,parameter of GH activity in acromegalic patients
UniProtKB/Swiss-Prot Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
UniProtKB/Swiss-Prot Induction: Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, EGF and phorbol esters

Gene Ontology (GO) - Molecular Function for IGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IBA --
GO:0005515 protein binding IPI 14561895
GO:0005520 insulin-like growth factor binding NAS 12599210
GO:0008160 protein tyrosine phosphatase activator activity IDA 11940579
GO:0031994 insulin-like growth factor I binding IPI 10766744
genes like me logo Genes that share ontologies with IGFBP3: view
genes like me logo Genes that share phenotypes with IGFBP3: view

Animal Models for IGFBP3 Gene

MGI Knock Outs for IGFBP3:

Animal Model Products

CRISPR Products

miRNA for IGFBP3 Gene

miRTarBase miRNAs that target IGFBP3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFBP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IGFBP3 Gene

Localization for IGFBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFBP3 Gene COMPARTMENTS Subcellular localization image for IGFBP3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 17119061
GO:0005634 nucleus IDA 17434920
GO:0016942 insulin-like growth factor binding protein complex IC 10766744
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IGFBP3: view

Pathways for IGFBP3 Gene

genes like me logo Genes that share pathways with IGFBP3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0001933 negative regulation of protein phosphorylation IDA 17591901
GO:0006468 protein phosphorylation IDA 17434920
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with IGFBP3: view

Compounds for IGFBP3 Gene

(1) Drugbank Compounds for IGFBP3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Mecasermin
68562-41-4 target

(133) Novoseek inferred chemical compound relationships for IGFBP3 Gene

Compound -log(P) Hits PubMed IDs
estradiol 65.8 108
testosterone 65.2 156
iplex 64.6 4
c-peptide 63 69
glucose 60.5 139
genes like me logo Genes that share compounds with IGFBP3: view

Transcripts for IGFBP3 Gene

Unigene Clusters for IGFBP3 Gene

Insulin-like growth factor binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFBP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - -
SP13: -
SP14: -
SP15: - -
SP16:

ExUns: 9e ^ 10 ^ 11a · 11b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:

Relevant External Links for IGFBP3 Gene

GeneLoc Exon Structure for
IGFBP3
ECgene alternative splicing isoforms for
IGFBP3

Expression for IGFBP3 Gene

mRNA expression in normal human tissues for IGFBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBP3 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGFBP3 Gene

SOURCE GeneReport for Unigene cluster for IGFBP3 Gene Hs.450230

mRNA Expression by UniProt/SwissProt for IGFBP3 Gene

P17936-IBP3_HUMAN
Tissue specificity: Expressed by most tissues. Present in plasma
genes like me logo Genes that share expressions with IGFBP3: view

In Situ Assay Products

Orthologs for IGFBP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBP3 35
  • 99.44 (n)
  • 100 (a)
IGFBP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGFBP3 35
  • 83.62 (n)
  • 83.74 (a)
IGFBP3 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGFBP3 35
  • 82.61 (n)
  • 81.42 (a)
IGFBP3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igfbp3 35
  • 83.1 (n)
  • 81.72 (a)
Igfbp3 16
Igfbp3 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFBP3 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP3 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igfbp3 35
  • 83.56 (n)
  • 82.07 (a)
chicken
(Gallus gallus)
Aves IGFBP3 35
  • 74.19 (n)
  • 75.1 (a)
IGFBP3 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGFBP3 36
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.12583 35
igfbp3 35
  • 61.94 (n)
  • 58.27 (a)
igfbp3 36
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for IGFBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP3 Gene

ENSEMBL:
Gene Tree for IGFBP3 (if available)
TreeFam:
Gene Tree for IGFBP3 (if available)

Paralogs for IGFBP3 Gene

Paralogs for IGFBP3 Gene

Selected SIMAP similar genes for IGFBP3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IGFBP3: view

Variants for IGFBP3 Gene

Sequence variations from dbSNP and Humsavar for IGFBP3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6670 -- 45,912,655(-) ATAGT(A/T)TGATA utr-variant-3-prime
rs9911 -- 45,913,403(-) ACCCC(A/G)GTCAT utr-variant-3-prime
rs1050566 -- 45,912,571(-) AAGGT(C/T)TGGCA utr-variant-3-prime
rs1800906 -- 45,915,582(-) TAATA(A/C)ATATG intron-variant
rs2132570 -- 45,922,864(-) GGGGC(A/C)CTCCA upstream-variant-2KB

Relevant External Links for IGFBP3 Gene

HapMap Linkage Disequilibrium report
IGFBP3
Human Gene Mutation Database (HGMD)
IGFBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGFBP3 Gene

Disorders for IGFBP3 Gene

(98) Novoseek inferred disease relationships for IGFBP3 Gene

Disease -log(P) Hits PubMed IDs
laron syndrome 84.6 12
growth hormone deficiency 82.1 48
short stature 81.8 62
growth failure 79.9 13
acromegaly 74.7 87

Relevant External Links for IGFBP3

Genetic Association Database (GAD)
IGFBP3
Human Genome Epidemiology (HuGE) Navigator
IGFBP3
genes like me logo Genes that share disorders with IGFBP3: view

No data available for UniProtKB/Swiss-Prot for IGFBP3 Gene

Publications for IGFBP3 Gene

  1. Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. (PMID: 1695633) Cubbage M.L. … Powell D.R. (J. Biol. Chem. 1990) 2 3 4 23
  2. Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators. (PMID: 11238520) Deal C. … Pollak M. (J. Clin. Endocrinol. Metab. 2001) 3 23 48
  3. Genetic and nongenetic factors associated with variation of plasma levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in healthy premenopausal women. (PMID: 11319179) JernstrAPm H. … Pollak M. (Cancer Epidemiol. Biomarkers Prev. 2001) 3 23 48
  4. Analysis of the primary structure of insulin-like growth factor binding protein-3 cDNA from Werner syndrome fibroblasts. (PMID: 7508771) Thweatt R. … Goldstein S. (DNA Seq. 1993) 3 4 23
  5. Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. (PMID: 14561895) Ikonen M. … Cohen P. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23

Products for IGFBP3 Gene

Sources for IGFBP3 Gene

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