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IGFBP3 Gene

protein-coding GIFtS: 69

GC07M045918

insulin-like growth factor binding protein 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BP-53 ^¹, ²
IBP-3 ^³
IBP3 ^¹, ², ³
IGFBP-3 ^³

Descriptions
IGF-binding protein 3 ^², ³
acid stable subunit of the 140 K IGF complex ^²
binding protein 29 ^²
binding protein 53 ^²
growth hormone-dependent binding protein ^²
insulin-like growth factor binding protein 3 ^²

External Ids
HGNC: 5472¹
Entrez Gene: 3486²
UniProtKB: P17936³
Ensembl: ENSG00000146674⁷

Search outside databases for aliases for IGFBP3 gene

Previous GC identifers: GC07M045598 GC07M045692 GC07M045725

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IGFBP3:

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes

a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary

complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like

growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life

of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional

splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either

inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the

interaction of IGFs with their cell surface receptors

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IGFBP3 gene

Entrez Gene cytogenetic band: 7p13-p12 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13-p12

IGFBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M045918: (about GC identifiers)

Start:	45,918,369 bp from pter
End:	45,927,396 bp from pter
Size:	9,028 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 45,991,173-46,000,198

RefSeq DNA sequence:

NC_000007.12 NT_007819.16 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936 (See protein sequence)

Recommended Name: Insulin-like growth factor-binding protein 3 precursor

Size: 291 amino acids; 31674 Da

Subunit: Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex

of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN

Subcellular location: Secreted

Developmental stage: IGFBP3 levels are higher during extrauterine life and peak during puberty

Secondary accessions: A4D2F5 Q2V509 Q6P1M6 Q9UCL4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000589.2 NP_001013416.1

ENSEMBL proteins:

ENSP00000370473 ENSP00000370476 ENSP00000275521

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant IGFBP3 Protein
	Sigma-Aldrich Proteins for IGFBP3
	R&D Systems Recombinant & Natural Proteins for IGFBP3 (IGFBP-3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IGFBP3)
	Human Recombinant Proteins from Abnova (IGFBP3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005634	nucleus	IDA	17434920
GO:0016942	insulin-like growth factor binding protein complex	IC	10766744

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Antibodies for IGFBP3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of IGFBP3
	Sigma-Aldrich Antibodies for IGFBP3
	R&D Systems Antibodies for IGFBP3 (IGFBP-3)
	Antibodies from Abcam (IGFBP3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IGFBP3)
	Search Novus for antibodies for IGFBP3

Assays for IGFBP3:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of IGFBP3
	R&D Systems ELISAs for IGFBP3 (IGFBP-3) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P17936

ProtoNet protein and cluster: P17936

2 Blocks protein families:

IPB000716 Thyroglobulin type-1

IPB000867 Insulin-like growth factor-binding protein

UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936

Domain: The thyroglobulin type-1 domain mediates interaction with HN

Similarity: Contains 1 IGFBP N-terminal domain

Similarity: Contains 1 thyroglobulin type-1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGFBP3)
		Millipore RNAi Products for the Analysis of IGFBP3 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (IGFBP3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000598

Applied Biosystems Silencer® siRNAs for IGFBP3

Sigma-Aldrich siRNA for IGFBP3

Sigma-Aldrich shRNA for IGFBP3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IGFBP3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000598
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000598
untagged cDNA clones in CMV expression vector (see all 2): NM_000598

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001013398

UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either

inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the

interaction of IGFs with their cell surface receptors

Induction: IGFBP3 levels increase in the presence of IGF1, insulin and other growth-stimulating

factors such as growth hormone, epidermal growth factor, and phorbol esters

Genatlas biochemistry entry for IGFBP3:

insulin-like growth factor binding protein 3,high affinity,expressed by liver and non hepatic

tissues,principal serum IGFBP,complexing with IGF1,IGF2 and an acid labile subunit. Mainly

regulated by GH. Regulator of cell somatic growth and cellular proliferation,either IGF dependent

or IGF independent,parameter of GH activity in acromegalic patients

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Igfbp3):

adipose tissue	digestive/alimentary	endocrine/exocrine gland	growth/size	homeostasis/metabolism
immune system	muscle

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008160	protein tyrosine phosphatase activator activity	IDA	11940579
GO:0031994	insulin-like growth factor I binding	IPI	10766744
GO:0046872	metal ion binding	NAS	14576163

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for IGFBP3 (Your Favorite Gene powered by Ingenuity)

RAR Activation
Growth Hormone Signaling
VDR/RXR Activation
IGF-1 Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation

GeneDecks IGFBP3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IGFBP3

5/50 Interacting proteins for IGFBP3 (P17936² ENSP00000370473³) via UniProtKB, MINT, and/or STRING (see all 50 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GTF3C1	Q12789²	MINT-63522
POLA2	Q14181²	MINT-63523
IGF1	ENSP00000302665³	STRING (score=.999)
IGFALS	ENSP00000215539³	STRING (score=.998)
IGF1R	ENSP00000268035³	STRING (score=.996)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0001933	negative regulation of protein amino acid phosphorylation	IDA	17591901
GO:0009968	negative regulation of signal transduction	NAS	11940579
GO:0014912	negative regulation of smooth muscle cell migration	IDA	10766744
GO:0043065	positive regulation of apoptosis	IMP	11971816

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for IGFBP3

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IGFBP3
10/32 Novoseek chemical compound relationships for IGFBP3 gene (see all 32 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
estradiol	64.99	134	7515764 (6), 9626134 (5), 8557625 (5), 14671165 (4) (see all 74)
c-peptide	63.29	73	14770423 (4), 11808715 (4), 11072255 (3), 17689128 (3) (see all 41)
glucose	60.35	241	11248744 (4), 7533774 (4), 18565922 (4), 15935983 (4) (see all 99)
dehydroepiandrosterone sulfate	59.73	49	9100552 (3), 12940521 (2), 11314741 (2), 10468952 (2) (see all 22)
androstenedione	58.14	35	9166698 (3), 16103701 (3), 11831514 (2), 15511959 (2) (see all 21)
deoxypyridinoline	48.94	12	10999783 (2), 15579182 (1), 10469009 (1), 9589671 (1) (see all 7)
dhea	47.38	27	11826868 (2), 16368782 (2), 15797966 (1), 17547689 (1) (see all 13)
pyridinoline	45.22	8	9745414 (2), 8864369 (1), 7540898 (1), 9589671 (1)
pegvisomant	44.27	9	17289896 (3), 11527090 (1), 16720661 (1), 16269873 (1) (see all 5)
ribonucleic acid	43.99	4	8855838 (1), 8550801 (1), 9048610 (1), 9100570 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGFBP3)
		Millipore RNAi Products for the Analysis of IGFBP3 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (IGFBP3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000598

Sigma-Aldrich siRNA for IGFBP3

Sigma-Aldrich shRNA for IGFBP3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000598 NM_001013398

REFSEQ mRNAs for IGFBP3 gene (2 alternative transcripts):

NM_000598.4 NM_001013398.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000598 NM_001013398

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000598
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000598
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000598

Additional cDNA sequence:

CR595168.1 CR603591.1 CR605771.1 CR610513.1 CR613455.1 CR615539.1 CR618433.1 S56205.1

24/90 DOTS entries (see all 90 ):

DT.100884556 DT.100884573 DT.102837268 DT.121120781 DT.101985495 DT.86859956 DT.100884575 DT.100884596

DT.100884577 DT.100884572 DT.121120613 DT.92464402 DT.100884603 DT.97769487 DT.97816827 DT.121120710

DT.100884547 DT.100045316 DT.100849103 DT.100884588 DT.92464401 DT.101966637 DT.95172120 DT.100884549

24/1222 AceView cDNA sequences (see all 1222 ):

AL551293 AI700215 BG424726 AL545572 C75417 BE206573 BU552480 CB163582

BM711003 BQ573800 BQ669128 R79931 BP372204 BQ669425 AA076641 CR618433

BQ574650 N74163 AI379830 BM759162 BQ925106 BX324761 BQ932857 BI496721

highest scoring ESTs for IGFBP3:

AI752416 AK092447 AK097201 AK125224 AL047210 AL516544 AL540851 AL543160 AL544281 AL545059

Unigene Clusters for IGFBP3:

Insulin-like growth factor binding protein 3

Hs.450230 [show with all ESTs], Hs.697535 [show with all ESTs]

Unigene Representative Sequences: NM_001013398, BF570082

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP3 (see all 16 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f	·	5g	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	·	9c	·	9d	·
SP1:									-		-		-		-										-		-						-												-
SP2:					-		-		-		-		-		-		-		-		-				-		-						-												-
SP3:							-		-		-		-		-		-								-		-						-												-
SP4:																									-		-						-												-
SP5:							-		-		-		-		-		-								-		-						-		-		-								-

ExUns:	9e	^	10	^	11a	·	11b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for IGFBP3

3 Ensembl transcripts including schematic representations:

ENST00000381083 ENST00000381086 ENST00000275521

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IGFBP3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IGFBP3

¹ / ² / ³

6 probe-sets matching IGFBP3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37319_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.02	M35878	0.20	0.50	0.38	1
1586_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.98	M35878	0.20	0.50	0.38	1
210095_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M31159	0.80	1.00	0.91	1
212143_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF340228	0.60	1.00	0.82	1
210095_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212143_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IGFBP3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTGAGGAAA

SOURCE GeneReport for Unigene clusters: Hs.450230 Hs.697535
Expression variation in blood from EXPOLDB for IGFBP3
UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936
Tissue specificity: Expressed by most tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for IGFBP3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IGFBP3¹	--	insulin-like growth factor binding protein 3	82.12(n) 80.28(a)	491618 XM_548740.2 XP_548740.2
chimpanzee (Pan troglodytes)	IGFBP3¹	--	insulin-like growth factor binding protein 3	99.31(n) 100(a)	463396 XM_519084.2 XP_519084.2
cow (Bos taurus)	IGFBP3¹	--	insulin-like growth factor binding protein 3	83.62(n) 83.74(a)	282261 NM_174556.1 NP_776981.1
rat (Rattus norvegicus)	Igfbp3¹	--	insulin-like growth factor binding protein 3	83.68(n) 82.41(a)	24484 NM_012588.1 NP_036720.1
mouse (Mus musculus)	Igfbp3^{1, 5}	11 (1.35 cM)⁵	insulin-like growth factor binding protein 3^{1, 5}	83.33(n)¹ 82.07(a)¹	16009¹ NM_008343.2¹ NP_032369.2¹ AI649005⁵ AI842277⁵ (see all 17)

About this table Species with no ortholog for IGFBP3

ENSEMBL Gene Tree for IGFBP3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IGFBP3 gene

IGFBP5² IGFBP6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/49 NCBI SNPs in IGFBP3 are shown (see all 49 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 81)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6670^1,2	A,C,F,H,O	45918779(-)	`GCTATA/TTGATA`	2	--	ut3¹		17	MN NA EU EA WA NS	1338
	rs2132572^1,2	A,C,F,H	45928070(-)	`ATTGGG/AGACTT`	2	--	ng3¹		13	EU EA WA MN NS	1272
	rs2132571^1,2	A,C,F,H	45928199(-)	`TTGTCG/ATGGGT`	2	--	ng3¹		9	EU EA WA NS	560
	rs2132570^1,2	A,C,F	45928988(-)	`GGGGCC/ACTCCA`	2	--	ng3¹		6	EA NS	1262
	rs3763500^1,2	F	45928379(+)	`CGGGGG/TCGCAA`	2	--	ng3¹		1	EA	1492
--	rs45566835^1,2	F	45918779(-)	`ATAGTA/TTGATA`	2	--	ut3¹		1	NA	44
--	rs35496550^1,2	F	45919202(-)	`GAGACA/-GGGAG`	2	--	ut3¹		5	NS	184
--	rs35751739^1,2	F	45919215(-)	`TAGGAG/AGGACA`	2	--	ut3¹		5	NS	186
--	rs2453840^1,2	C,F,H	45920337(+)	`TAATAC/G/TCATTC`	2	--	int¹		9	EU EA WA NS	570
	rs10255707^1,2	C,F,H	45921217(+)	`AGCCAC/TGCGTG`	2	--	int¹		8	EU EA NS	480

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HapMap Linkage Disequilibrium images for IGFBP3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 146732

10/98 Novoseek disease relationships for IGFBP3 gene (see all 98 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
laron syndrome	84.66	12	17350302 (3), 9437227 (2), 15751611 (1), 16403822 (1) (see all 9)
growth hormone deficiency	82.40	62	10469014 (3), 9835431 (3), 7543832 (2), 7518726 (2) (see all 33)
short stature	81.60	74	15679071 (3), 16820702 (2), 10932487 (2), 11207641 (2) (see all 49)
growth failure	79.46	16	10359158 (2), 16507628 (2), 9186890 (1), 12405432 (1) (see all 11)
acromegaly	74.82	111	7586626 (8), 9231047 (5), 10195375 (5), 7533774 (5) (see all 37)
growth retardation	67.56	31	11207641 (3), 17726072 (2), 8894649 (1), 9795360 (1) (see all 23)
igf-i resistance	66.61	5	15476454 (1), 16311944 (1), 12153610 (1), 12917202 (1)
growth disorders	64.53	8	1700965 (2), 16462144 (1), 7951670 (1), 12818134 (1) (see all 5)
prostate cancer	61.59	306	17404112 (6), 14674736 (6), 15356036 (6), 18097534 (5) (see all 99)
breast cancer	60.84	473	8609661 (7), 10067859 (6), 17287408 (6), 17416768 (6) (see all 99)

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Human Gene Mutation Database: IGFBP3
Genetic Association Database: IGFBP3
Human Genome Epidemiology Navigator: IGFBP3 (83 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1831 PubMed articles for IGFBP3 gene (see all 1831 ):

Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. (PubMed id 1695633)^{2, 3, 4} Cubbage M.L.... Powell D.R. (1990)
A polymorphic locus in the promoter region of the IGFBP3 gene is related to mammographic breast density. (PubMed id 15066922)^{1, 3, 6} Lai J.H....Narod S.A. (2004)
Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women. (PubMed id 15298948)^{1, 3, 6} Ren Z....Zheng W. (2004)
IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer. (PubMed id 15800934)^{1, 3, 6} Friedrichsen D.M....Stanford J.L. (2005)
Polymorphisms in the IGF-1 and IGFBP 3 promoter and the risk of breast cancer. (PubMed id 15986122)^{1, 3, 6} Wagner K....Forsti A. (2005)
Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review. (PubMed id 15668470)^{1, 3, 6} Fletcher O....Silva I.d.o.s. .S. (2005)
Association of an exon 1 polymorphism in the IGFBP3 gene with circulating IGFBP-3 levels and colorectal cancer risk: the multiethnic cohort study. (PubMed id 15894694)^{1, 3, 6} Le Marchand L....Wilkens L.R. (2005)
Promoter -202 A/C polymorphism of insulin-like growth factor binding protein-3 gene and non-small cell lung cancer risk. (PubMed id 16049980)^{1, 3, 6} Moon J.W....Kim S.K. (2006)
Insulin-like growth factor polymorphisms and colorectal cancer risk. (PubMed id 15894673)^{1, 3, 6} Morimoto L.M....Potter J.D. (2005)
Polymorphic variation at the -202 locus in IGFBP3: Influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk. (PubMed id 12925957)^{1, 3, 6} Schernhammer E.S....Pollak M.N. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3486	HGNC: 5472	AceView: IGFBP3	Ensembl:ENSG00000146674	euGenes: HUgn3486
ECgene: IGFBP3	H-InvDB: IGFBP3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IGFBP3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/igfbp3/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IGFBP3

Licensable Technologies for IGFBP3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IGFBP3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IGFBP3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IGFBP3		Antibodies for IGFBP3
	Explore super-pooled esiRNAs		Proteins for IGFBP3
	Lentivirus-delivered shRNAs for IGFBP3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IGFBP3)
	Antibodies (IGFBP3)
	Chimera RNAi (IGFBP3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (IGFBP3)

Search OriGene for IGFBP3

Search Tocris compounds for IGFBP3

	Drugs for IGFBP3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for IGFBP3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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IGFBP3 Gene at Home site.
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IGFBP3 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for IGFBP3

Summaries
for IGFBP3

Genomic Location
for IGFBP3

Proteins
for IGFBP3

Protein Domains/
Families
for IGFBP3

Gene Function
for IGFBP3

Pathways & Interactions
for IGFBP3

Drugs & Compounds
for IGFBP3

Transcripts
for IGFBP3

Expression
for IGFBP3

Orthologs
for IGFBP3

Paralogs
for IGFBP3

SNPs/Variants
for IGFBP3

Disorders & Mutations
for IGFBP3

Medical News
for IGFBP3

Publications
for IGFBP3

Search for IGFBP3

Genome Databases showing IGFBP3

Other Databases showing IGFBP3

Specialized Databases showing IGFBP3

Licensable Technologies
for IGFBP3

Services
for IGFBP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IGFBP3 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor IGFBP3

Summariesfor IGFBP3

Genomic Locationfor IGFBP3

Proteinsfor IGFBP3

Protein Domains/Familiesfor IGFBP3

Gene Functionfor IGFBP3

Pathways & Interactionsfor IGFBP3

Drugs & Compoundsfor IGFBP3

Transcriptsfor IGFBP3

Expression for IGFBP3

Orthologsfor IGFBP3

Paralogsfor IGFBP3

SNPs/Variantsfor IGFBP3

Disorders & Mutationsfor IGFBP3

Medical Newsfor IGFBP3

Publicationsfor IGFBP3

Search for IGFBP3

Genome Databases showing IGFBP3

Other Databases showing IGFBP3

Specialized Databases showing IGFBP3

Licensable Technologiesfor IGFBP3

Servicesfor IGFBP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IGFBP3

Summaries
for IGFBP3

Genomic Location
for IGFBP3

Proteins
for IGFBP3

Protein Domains/
Families
for IGFBP3

Gene Function
for IGFBP3

Pathways & Interactions
for IGFBP3

Drugs & Compounds
for IGFBP3

Transcripts
for IGFBP3

Expression
for IGFBP3

Orthologs
for IGFBP3

Paralogs
for IGFBP3

SNPs/Variants
for IGFBP3

Disorders & Mutations
for IGFBP3

Medical News
for IGFBP3

Publications
for IGFBP3

Licensable Technologies
for IGFBP3

Services
for IGFBP3