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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGFBP3 Gene

protein-coding   GIFtS: 69
GCID: GC07M045918

insulin-like growth factor binding protein 3
 Explore 232 diseases affiliated with
IGFBP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGFBP3    

Aliases
for IGFBP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Insulin-Like Growth Factor Binding Protein 31 2     Acid Stable Subunit Of The 140 K IGF Complex2
IBP31 2 3     Binding Protein 292
BP-531 2     Binding Protein 532
IBP-32 3     Growth Hormone-Dependent Binding Protein2
IGFBP-32 3     Insulin-Like Growth Factor-Binding Protein 32
IGF-Binding Protein 32 3     

External Ids:    HGNC: 54721   Entrez Gene: 34862   Ensembl: ENSG000001466747   OMIM: 1467325   UniProtKB: P179363   

Export aliases for IGFBP3 gene to outside databases

Previous GC identifers: GC07M045598 GC07M045692 GC07M045725 GC07M045836


Summaries
for IGFBP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IGFBP3:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an
IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor
acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the
plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate
transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the
growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface
receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor
TMEM219/IGFBP-3R

Gene Wiki entry for IGFBP3


Genomic Views
for IGFBP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGFBP3 gene promoter:
         TBP   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): IGFBP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGFBP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13-p12   Ensembl cytogenetic band:  7p12.3   HGNC cytogenetic band: 7p13-p12

IGFBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M045918:  view genomic region     (about GC identifiers)

Start:
 45,951,844 bp from pter      End:
 45,961,473 bp from pter
Size:
 9,630 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 45,991,173-46,000,198     

Proteins
for IGFBP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 3 precursor  
Size: 291 amino acids; 31674 Da
Subunit: Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150
kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219
Subcellular location: Secreted
Developmental stage: IGFBP3 levels are higher during extrauterine life and peak during puberty
Secondary accessions: A4D2F5 D3DVM0 Q2V509 Q6P1M6 Q9UCL4

Explore the universe of human proteins at neXtProt for IGFBP3: NX_P17936

Post-translational modifications:

  • Phosphorylation sites are present in the extracellular medium1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17936

    • IGFBP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000589.2  NP_001013416.1  

    ENSEMBL proteins: 
     ENSP00000275521   ENSP00000370476   ENSP00000370473   ENSP00000390298   ENSP00000399116  
     ENSP00000389668  
    Reactome Protein details: P17936
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant IGFBP3 Protein
    R&D Systems Recombinant & Natural Proteins for IGFBP3 (IGFBP-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): IGFBP3
    OriGene Custom Protein Services for IGFBP3 
    GenScript Purified and Recombinant Proteins for IGFBP3
    Novus Biologicals IGFBP3 Proteins
    Novus Biologicals IGFBP3 Lysate
    Sino Biological Recombinant Protein for IGFBP3
    ProSpec Recombinant Protein for IGFBP3
    Uscn Proteins for IGFBP3

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA17119061
    GO:0005634nucleus IDA17434920
    GO:0016942insulin-like growth factor binding protein complex IC10766744
    GO:0042567insulin-like growth factor ternary complex ----


    IGFBP3 for ontologies           About GeneDecksing



    IGFBP3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IGFBP3
    R&D Systems Antibodies for IGFBP3 (IGFBP-3)
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    Abcam antibodies for IGFBP3 
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    ThermoFisher Antibodies for IGFBP3

    Assay Products for IGFBP3: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for IGFBP3 (IGFBP-3)         (see all)
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IGFBP3

    Protein Domains /
    Families
    for IGFBP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGFBP3 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000716 Thyroglobulin_1
     IPR022321 IGFBP_1-6_chordata
     IPR000867 IGFBP-like
     IPR009168 IGFBP1-6
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry P17936

    ProtoNet protein and cluster: P17936

    2 Blocks protein families:
    IPB000716 Thyroglobulin type-1
    IPB000867 Insulin-like growth factor-binding protein


    UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936
    Domain: The thyroglobulin type-1 domain mediates interaction with HN
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    Function
    for IGFBP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936
    Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the
    growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface
    receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor
    TMEM219/IGFBP-3R
    Induction: Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone,
    EGF and phorbol esters

         Genatlas biochemistry entry for IGFBP3:
    insulin-like growth factor binding protein 3,high affinity,expressed by liver and non hepatic tissues,principal serum
    IGFBP,complexing with IGF1,IGF2 and an acid labile subunit. Mainly regulated by GH. Regulator of cell somatic growth
    and cellular proliferation,either IGF dependent or IGF independent,parameter of GH activity in acromegalic patients

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): IGFBP3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBP3
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP3 (see all 30):
    hsa-miR-485-5p hsa-miR-448 hsa-miR-875-3p hsa-miR-575 hsa-miR-628-3p hsa-miR-340 hsa-miR-197 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: IGFBP3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFBP3 (see all 7)
    OriGene shRNA RFP: IGFBP3
    OriGene siRNA: IGFBP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBP3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IGFBP3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): IGFBP3 (NM_001013398)
    Sino Biological Human cDNA Clone for IGFBP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP3 

    Cell Line
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    Search LifeMap BioReagents cell lines for IGFBP3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP3

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005515protein binding IPI14561895
    GO:0005520insulin-like growth factor binding NAS12599210
    GO:0008160protein tyrosine phosphatase activator activity IDA11940579
    GO:0031994insulin-like growth factor I binding IPI10766744


    IGFBP3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Igfbp3tm1Jep for IGFBP3
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Igfbp3):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     liver/biliary system  muscle 

    IGFBP3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IGFBP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development IGF-RI signaling
    		Development IGF-RI signaling1.00
    		Development_IGF-1 receptor signaling0.99
    2Integrated Pancreatic Cancer Pathway
    		Integrated Pancreatic Cancer Pathway1.00
    		Integrated Pancreatic Cancer Pathway0.99
    3Development_CNTF receptor signaling
    		Transcription Receptor-mediated HIF regulation0.43
    		Transcription_Receptor-mediated HIF regulation0.43
    4Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    		Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)1.00
    5Celecoxib Pathway, Pharmacodynamics
    		Celecoxib Pathway, Pharmacodynamics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for IGFBP3
        Transcription Receptor-mediated HIF regulation
    Development IGF-RI signaling


    2 GeneGo (Thomson Reuters) Pathways for IGFBP3
        Transcription Receptor-mediated HIF regulation
    Development IGF-1 receptor signaling

    4 BioSystems Pathways for IGFBP3 
        Myometrial Relaxation and Contraction Pathways
    Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Direct p53 effectors

    2        Reactome Pathways for IGFBP3
        Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Metabolism of proteins

    1 PharmGKB Pathway for IGFBP3
        Celecoxib Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for IGFBP3):
        p53 signaling pathway


    IGFBP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGFBP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for IGFBP3 (P179362, 3 ENSP000003704734) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLA2Q141812, 3MINT-63523 I2D: score=5 
    GTF3C1Q127892, 3, ENSP000003485104MINT-63522 I2D: score=5 STRING: ENSP00000348510
    COL1A1P024523, ENSP000002259644I2D: score=3 STRING: ENSP00000225964
    FN1P027513, ENSP000003468394I2D: score=3 STRING: ENSP00000346839
    IGF1P050193, ENSP000003026654I2D: score=3 STRING: ENSP00000302665
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0001933negative regulation of protein phosphorylation IDA17591901
    GO:0006468protein phosphorylation IDA17434920
    GO:0006915apoptotic process IEA--
    GO:0008285negative regulation of cell proliferation IGI19258508


    IGFBP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IGFBP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGFBP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGFBP3

    1 DrugBank Compound for IGFBP3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Mecasermin-- 68562-41-4targetother/unknown17054474 19627167 16610982 17380212 20122448 16548790 16905026 18363546

    10/133 Novoseek chemical compound relationships for IGFBP3 gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estradiol 65.8 141 7515764 (6), 9626134 (5), 8557625 (5), 14671165 (4) (see all 78)
    testosterone 65.2 264 18097534 (7), 16541420 (6), 14671165 (5), 16825320 (4) (see all 99)
    iplex 64.6 6 15777106 (2), 16610982 (1), 16548790 (1)
    c-peptide 63 75 14770423 (4), 11808715 (4), 11072255 (3), 17689128 (3) (see all 42)
    glucose 60.5 261 11248744 (4), 7533774 (4), 18565922 (4), 17487212 (4) (see all 99)
    dehydroepiandrosterone sulfate 60.2 49 9100552 (3), 12940521 (2), 11314741 (2), 10468952 (2) (see all 22)
    androstenedione 58.1 36 9166698 (3), 16103701 (3), 11831514 (2), 15511959 (2) (see all 22)
    estrogen 52.4 109 10524681 (4), 10843175 (4), 8768841 (3), 12629097 (3) (see all 49)
    pegvisomant 52.1 9 17289896 (3), 11527090 (1), 16720661 (1), 16269873 (1) (see all 5)
    octreotide 51.7 52 7535670 (5), 7534239 (3), 8543925 (2), 10806600 (2) (see all 23)

    Search CenterWatch for drugs/clinical trials and news about IGFBP3 / IBP3 

    Transcripts
    for IGFBP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IGFBP3 gene (2 alternative transcripts): 
    NM_000598.4  NM_001013398.1  

    Unigene Cluster for IGFBP3:

    Insulin-like growth factor binding protein 3
    Hs.450230  [show with all ESTs]
    Unigene Representative Sequence: NM_001013398
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275521(uc003tnq.3 uc003tnr.3 uc003tns.3 uc003tnt.3)
    ENST00000381086 ENST00000460209 ENST00000381083 ENST00000428530 ENST00000417621
    ENST00000448817 ENST00000465642 ENST00000460477

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBP3
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP3 (see all 30):
    hsa-miR-485-5p hsa-miR-448 hsa-miR-875-3p hsa-miR-575 hsa-miR-628-3p hsa-miR-340 hsa-miR-197 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: IGFBP3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFBP3 (see all 7)
    OriGene shRNA RFP: IGFBP3
    OriGene siRNA: IGFBP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBP3
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): IGFBP3 (NM_001013398)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP3 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IGFBP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP3

    Additional cDNA sequence: 

    AF370418.1 AK055632.1 AK056274.1 AK075483.1 AK091706.1 AK091745.1 AK092447.1 AK095408.1 
    AK095864.1 AK095869.1 AK095900.1 AK095907.1 AK095974.1 AK095991.1 AK097201.1 AK122873.1 
    AK123735.1 AK125224.1 AK127537.1 AK129951.1 AK130884.1 AK297767.1 AK298143.1 AK315668.1 
    BC000013.2 BC018962.2 BC064987.1 DQ884396.1 DQ884397.1 DQ884398.1 M31159.1 S56205.1 
    X64875.1 

    24/90 DOTS entries (see all 90):

    DT.100884556  DT.100884573  DT.102837268  DT.121120781  DT.100884575  DT.100884577  DT.121120613  DT.100884572 
    DT.92464402  DT.101985495  DT.86859956  DT.100884596  DT.100884603  DT.97769487  DT.121120710  DT.97816827 
    DT.92464401  DT.100045316  DT.95172120  DT.100884588  DT.101966637  DT.100849103  DT.100884547  DT.91937442 

    24/1222 AceView cDNA sequences (see all 1222):

    AA173557 AI304602 AW732507 BI870206 CB144574 CN483339 BU185020 BP335454 
    AI520755 BX417506 AA375301 BP341624 BQ670242 AL551354 CN484073 AI862589 
    BU146146 AI333407 AI360546 BG424726 AK075483 BQ672807 CA311616 CB150227 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP3 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ·
    SP1:                          -     -     -     -                             -     -                 -                                   -                     
    SP2:              -     -     -     -     -     -     -     -     -           -     -                 -                                   -                     
    SP3:                    -     -     -     -     -     -                       -     -                 -                                   -                     
    SP4:                                                                          -     -                 -                                   -                     
    SP5:                    -     -     -     -     -     -                       -     -                 -     -     -                       -                     

    ExUns: 9e ^ 10 ^ 11a · 11b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for IGFBP3

    Expression
    for IGFBP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGFBP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTGAGGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IGFBP3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    ChorionChorion BilayerChorionic Mesoderm CellsExtraembryonic Tissues, Placenta
    HeartHeart TubeHeart
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    N2/LSB/S/F8-induced cells (Generation of midbra...)
    N2/LSB induced-cells (Generation of midbra...)
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Primitive gut tube-like cells (A scalable, suspensi...)
    Embryoid bodies (Two-step protocol fo...)

    See IGFBP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGFBP3

    SOURCE GeneReport for Unigene cluster: Hs.450230

    UniProtKB/Swiss-Prot: IBP3_HUMAN, P17936
    Tissue specificity: Expressed by most tissues. Present in plasma

        SABiosciences Expression via Pathway-Focused PCR Arrays including IGFBP3 (see all 10): 
              mTOR Signaling in human mouse rat
              Nephrotoxicity in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGFBP3
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP3
    In Situ
    Assay Products:     
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    Orthologs
    for IGFBP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP3 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IGFBP31 insulin-like growth factor binding protein 3 72.64(n)
    72.4(a)    		   420790  NM_001101034.1  NP_001094504.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IGFBP36
    		 --
    		 60(a)
    		 1 ↔ 1
    		 6(53880656-53906923)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.125832 Danio rerio mRNA for insulin-like growth factor binding more 75.3(n)    AJ299410.1 


    ENSEMBL Gene Tree for IGFBP3 (if available)
    TreeFam Gene Tree for IGFBP3 (if available) 

    Paralogs
    for IGFBP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGFBP3 gene
    IGFBP52  IGFBP22  IGFBP12  IGFBP62  IGFBP42  
    3 SIMAP similar genes for IGFBP3 using alignment to 5 protein entries:     IBP3_HUMAN (see all proteins):
    IGFBP5    IGFBP2    IGFBP4

    IGFBP3 for paralogs           About GeneDecksing



    Genomic Variants
    for IGFBP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/218 NCBI SNPs in IGFBP3 are shown (see all 218)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs25156971,2
    		H--45840367(-) TCCGAC/GTCACT 2 -- int14Minor allele frequency- G:0.00NS EA 420
    rs1887963031,2
    		--45951457(+) GAACCC/TCTTCT 2 -- ds50010--------
    rs1932915951,2
    		--45951515(+) CAAAGA/CGGTAA 2 -- ds50010--------
    rs1419538011,2
    		--45951821(+) GTTATA/GAAGTT 2 -- ds50010--------
    rs2001997921,2
    		--45951868(+) TTTAT-/TATAATAA
    AATAATTATTA    TATAA     		2 -- ut310--------
    rs1838021501,2
    		--45951887(+) TATTAC/TATAAT 2 -- ut310--------
    rs1457336661,2
    		--45951894(+) TAATAA/CAATAA 2 -- ut310--------
    rs1879674661,2
    		--45951988(+) TATAAA/GTACAT 2 -- ut310--------
    rs1382749191,2
    		--45951993(+) ATACAC/TTGCAA 2 -- ut310--------
    rs1913062081,2
    		--45952212(+) TCTCTC/GGGCGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for IGFBP3 (45951844 - 45961473 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IGFBP3: --
    Human Gene Mutation Database (HGMD): IGFBP3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFBP3
    DNA2.0 Custom Variant and Variant Library Synthesis for IGFBP3

    Disorders / Diseases
    for IGFBP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGFBP3 for disorders           About GeneDecksing

    OMIM gene information: 146732    OMIM disorders: --

    20/232 diseases for IGFBP3 (see all 232):    About MalaCards
    acid-labile subunit    rabson-mendenhall syndrome    recessive dystrophic epidermolysis bullosa    protein-energy malnutrition
    21-hydroxylase deficiency    diffuse idiopathic skeletal hyperostosis    silver-russell syndrome    growth hormone deficiency
    empty sella syndrome    pituitary hormone deficiency    epidermolysis bullosa    combined pituitary hormone deficiency
    proliferative diabetic retinopathy    focal segmental glomerulosclerosis    mccune albright syndrome    prader-willi syndrome
    renal clear cell carcinoma    endemic goiter    short stature    marasmus

    9 diseases from the University of Copenhagen DISEASES database for IGFBP3:
    Acromegaly     Prostate cancer     Breast cancer     Diabetes mellitus
    Turner syndrome     Hypoglycemia     Colorectal cancer     Hypopituitarism
    Osteoporosis

    10/98 Novoseek disease relationships for IGFBP3 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    laron syndrome 84.6 12 17350302 (3), 9437227 (2), 15751611 (1), 16403822 (1) (see all 9)
    growth hormone deficiency 82.1 64 10469014 (3), 9835431 (3), 7543832 (2), 7518726 (2) (see all 34)
    short stature 81.8 78 19381505 (3), 15679071 (3), 16820702 (2), 10932487 (2) (see all 51)
    growth failure 79.9 16 10359158 (2), 16507628 (2), 9186890 (1), 12405432 (1) (see all 11)
    acromegaly 74.7 118 7586626 (8), 9231047 (5), 10195375 (5), 7533774 (5) (see all 40)
    igf-i resistance 69.4 5 15476454 (1), 16311944 (1), 12153610 (1), 12917202 (1)
    growth retardation 67.9 34 11207641 (3), 17726072 (2), 8894649 (1), 9795360 (1) (see all 25)
    growth disorders 65.2 10 1700965 (2), 19494704 (1), 16462144 (1), 7951670 (1) (see all 6)
    prostate cancer 62.8 333 17404112 (6), 14674736 (6), 15356036 (6), 18097534 (5) (see all 99)
    breast cancer 61 511 19888649 (8), 8609661 (7), 10067859 (6), 17287408 (6) (see all 99)

    Genetic Association Database (GAD): IGFBP3
    Human Genome Epidemiology (HuGE) Navigator: IGFBP3 (144 documents)

    Export disorders for IGFBP3 gene to outside databases

    Publications
    for IGFBP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGFBP3 gene, integrated from 9 sources (see all 2278):
    (articles sorted by number of sources associating them with IGFBP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. (PubMed id 1695633)1, 2, 3, 9 Cubbage M.L.... Powell D.R. (1990)
    2. A polymorphic locus in the promoter region of the IGFBP3 gene is related to mammographic breast density. (PubMed id 15066922)1, 4, 9 Lai J.H....Narod S.A. (2004)
    3. Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women. (PubMed id 15298948)1, 4, 9 Ren Z....Zheng W. (2004)
    4. Polymorphisms in the IGF-1 and IGFBP 3 promoter and the risk of breast cancer. (PubMed id 15986122)1, 4, 9 Wagner K....Forsti A. (2005)
    5. Association of an exon 1 polymorphism in the IGFBP3 gene with circulating IGFBP-3 levels and colorectal cancer risk: the multiethnic cohort study. (PubMed id 15894694)1, 4, 9 Le Marchand L....Wilkens L.R. (2005)
    6. IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer. (PubMed id 15800934)1, 4, 9 Friedrichsen D.M....Stanford J.L. (2005)
    7. Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review. (PubMed id 15668470)1, 4, 9 Fletcher O....Silva I.d.o.s. .S. (2005)
    8. Promoter -202 A/C polymorphism of insulin-like growth factor binding protein-3 gene and non-small cell lung cancer risk. (PubMed id 16049980)1, 4, 9 Moon J.W....Kim S.K. (2006)
    9. Insulin-like growth factor polymorphisms and colorectal cancer risk. (PubMed id 15894673)1, 4, 9 Morimoto L.M....Potter J.D. (2005)
    10. Comprehensive assessment of candidate genes and serological markers for the detection of prostate cancer. (PubMed id 14693733)1, 4, 9 Nam R.K....Narod S.A. (2003)

    External Searches for IGFBP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IGFBP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3486 HGNC: 5472 AceView: IGFBP3 Ensembl:ENSG00000146674 euGenes: HUgn3486
    ECgene: IGFBP3 Kegg: 3486 H-InvDB: IGFBP3

    Other Databases showing IGFBP3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IGFBP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGFBP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGFBP3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp3/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IGFBP3

    Intellectual Property
    for IGFBP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGFBP3 gene:
    Search GeneIP for patents involving IGFBP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IGFBP3 gene

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    About This Section

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