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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGFBP2 Gene

protein-coding   GIFtS: 66
GCID: GC02P217497

Insulin-Like Growth Factor Binding Protein 2, 36kDa

(Previous name: insulin-like growth factor binding protein 2 (36kD))
(Previous symbol: IBP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin-Like Growth Factor Binding Protein 2, 36kDa1 2     Insulin-Like Growth Factor Binding Protein 2 (36kD)1
IBP21 2 3     IGF-BP532
IBP-22 3     Insulin-Like Growth Factor-Binding Protein 22
IGFBP-22 3     BP23
IGF-Binding Protein 22 3     

External Ids:    HGNC: 54711   Entrez Gene: 34852   Ensembl: ENSG000001154577   OMIM: 1467315   UniProtKB: P180653   

Export aliases for IGFBP2 gene to outside databases

Previous GC identifers: GC02P215595 GC02P216219 GC02P217462 GC02P217700 GC02P217323 GC02P217206 GC02P209352


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGFBP2 Gene: 
IGFBP2 (insulin-like growth factor binding protein 2, 36kDa) is a protein-coding gene. Diseases associated with IGFBP2 include malignant ovarian cyst, and 3-m syndrome, and among its related super-pathways are Signal transduction AKT signaling and Calcium Regulation in the Cardiac Cell. GO annotations related to this gene include insulin-like growth factor II binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot: IBP2_HUMAN, P18065
Function: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the
IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.
They alter the interaction of IGFs with their cell surface receptors

Gene Wiki entry for IGFBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGFBP2 gene promoter:
         CREB   PPAR-gamma1   POU2F1   deltaCREB   POU2F1a   STAT3   PPAR-gamma2   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGFBP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGFBP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q34   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q33-q34

IGFBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P217497:  view genomic region     (about GC identifiers)

Start:
217,497,551 bp from pter      End:
217,529,159 bp from pter
Size:
31,609 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IBP2_HUMAN, P18065 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 2 precursor  
Size: 325 amino acids; 34814 Da
Subunit: Binds IGF2 more than IGF1
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for IGFBP2:
2H7T (3D)    
Secondary accessions: Q14619 Q9UCL3

Explore the universe of human proteins at neXtProt for IGFBP2: NX_P18065

Explore proteomics data for IGFBP2 at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P18065

  • IGFBP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGFBP2 Protein Expression
    REFSEQ proteins: NP_000588.2  
    ENSEMBL proteins: 
     ENSP00000401698   ENSP00000233809   ENSP00000389646   ENSP00000400308  
    Reactome Protein details: P18065
    Human Recombinant Protein Products for IGFBP2: 
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    Novus Biologicals IGFBP2 Protein
    Novus Biologicals IGFBP2 Lysates
    Sino Biological Recombinant Protein for IGFBP2
    Sino Biological Cell Lysate for IGFBP2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IGFBP2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA15694994
    GO:0016324apical plasma membrane IEA--
    GO:0031410cytoplasmic vesicle IEA--

    IGFBP2 for ontologies           About GeneDecksing



    IGFBP2 Antibody Products: 
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    Assay Products for IGFBP2: 
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    Cloud-Clone Corp. ELISAs for IGFBP2 
    Cloud-Clone Corp. CLIAs for IGFBP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR000716 Thyroglobulin_1
     IPR022321 IGFBP_1-6_chordata
     IPR000867 IGFBP-like
     IPR012210 IGFBP-2
     IPR009168 IGFBP1-6

    Graphical View of Domain Structure for InterPro Entry P18065

    ProtoNet protein and cluster: P18065

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB000867 Insulin-like growth factor-binding protein


    UniProtKB/Swiss-Prot: IBP2_HUMAN, P18065
    Domain: The C-terminus is required for IGF-binding and growth inhibition
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    IGFBP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBP2_HUMAN, P18065
    Function: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the
    IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.
    They alter the interaction of IGFs with their cell surface receptors

         Genatlas biochemistry entry for IGFBP2:
    insulin-like growth factor binding protein 2 ,high affinity,regulator of somatic growth and cellular
    proliferation,major IGFBP of the spinal fluid expressed by multiple neural tissues,highly expressed in infancy
    and older age adult,deregulated in pancreatic beta cell tumorigenesis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19095771
    GO:0005520insulin-like growth factor binding ----
    GO:0031994insulin-like growth factor I binding IDA19081843
    GO:0031995insulin-like growth factor II binding ISS--
         
    IGFBP2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for IGFBP2:
     Decreased viability of wild-ty  Increased G1 DNA content  Increased gamma-H2AX phosphory  Increased number of mitotic ce 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Igfbp2):
     cardiovascular system  hematopoietic system  immune system  liver/biliary system  normal 
     renal/urinary system 

    IGFBP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Igfbp2tm1Jep for IGFBP2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGFBP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGFBP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGFBP2 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidIGFBP2 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGFBP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    2Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    5Glucose / Energy Metabolism
    Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IGFBP2
        Development IGF-RI signaling


    1 Cell Signaling Technology (CST) Pathway for IGFBP2
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for IGFBP2
        Development IGF-1 receptor signaling

    1 BioSystems Pathway for IGFBP2
        Myometrial Relaxation and Contraction Pathways


    2        Reactome Pathways for IGFBP2
        Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Metabolism of proteins



    IGFBP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGFBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for IGFBP2 (P180651, 3 ENSP000002338094) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INO80BQ9C0861, 3, ENSP000002333314EBI-2504392,EBI-715611 I2D: score=1 STRING: ENSP00000233331
    IGF1P050193, ENSP000003026654I2D: score=3 STRING: ENSP00000302665
    IGF2P013443, ENSP000003382974I2D: score=1 STRING: ENSP00000338297
    KLK2P201513, ENSP000003135814I2D: score=1 STRING: ENSP00000313581
    TFP027873, ENSP000002649984I2D: score=2 STRING: ENSP00000264998
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0006950response to stress IEA--
    GO:0007165signal transduction IEA--
    GO:0007565female pregnancy IEA--
    GO:0007568aging IEA--

    IGFBP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGFBP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for IGFBP2 (IBP2)

    10/64 Novoseek inferred chemical compound relationships for IGFBP2 gene (see all 64)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribonucleic acid 49.3 7 7519190 (2), 9435438 (2), 8550786 (1), 8949894 (1)
    c-peptide 48.7 16 17285578 (4), 11808715 (4), 8887130 (2), 12708727 (1) (see all 9)
    androstenedione 41.4 10 11831514 (2), 11906932 (2), 9166698 (2), 14668202 (1) (see all 6)
    estradiol 41.2 21 17289850 (3), 11831514 (2), 20226513 (2), 7508947 (1) (see all 14)
    progesterone 31.5 27 1719019 (4), 15809018 (3), 1706350 (2), 11906932 (1) (see all 12)
    procollagen 30.6 6 12201833 (1), 12519882 (1), 9745414 (1), 15546908 (1)
    testosterone 29.7 22 20407609 (5), 16368782 (4), 9618803 (1), 7533776 (1) (see all 10)
    estrogen 28.8 19 12629097 (3), 15809018 (2), 10992179 (1), 18373644 (1) (see all 13)
    glucose 26.8 23 18565922 (4), 19558480 (3), 12496045 (2), 16556765 (2) (see all 14)
    thymidine 25.7 5 9169346 (2), 15994346 (1), 16684509 (1)

    Search CenterWatch for drugs/clinical trials and news about IGFBP2 / IBP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IGFBP2 gene: 
    NM_000597.2  

    Unigene Cluster for IGFBP2:

    Insulin-like growth factor binding protein 2, 36kDa
    Hs.438102  [show with all ESTs]
    Unigene Representative Sequence: AB209509
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434997 ENST00000233809(uc021vwn.1) ENST00000490362(uc010zju.2)
    ENST00000456764 ENST00000436812
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    Additional mRNA sequence: 

    AB209509.1 BC004312.1 BC009902.1 BC012769.1 BC071967.1 M35410.1 X16302.1 

    10 DOTS entries:

    DT.455798  DT.100641719  DT.100644888  DT.100715276  DT.97800939  DT.97765820  DT.100038198  DT.102831825 
    DT.121020335  DT.95103302 

    24/412 AceView cDNA sequences (see all 412):

    AW273491 BM707931 BF337577 BG057953 BG150531 AW161913 AI744135 CR596315 
    BU728144 AA152182 AL525517 AA459532 CR623237 AI669991 CR611812 BM888377 
    CR606776 BQ218754 AW172776 AW192270 AA035641 BM998592 AI582123 CR614828 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b
    SP1:              -                 -                           
    SP2:        -     -                 -                           
    SP3:                                -                           
    SP4:                                                            


    ECgene alternative splicing isoforms for IGFBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGFBP2 expression in normal human tissues (normalized intensities)      IGFBP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGTACAA
    IGFBP2 Expression
    About this image


    IGFBP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             Brain Pericytes   
             Septum   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Epiphyseal End
             HyStem+BMP4-induced SK11 cells
             Human Calvarial Osteoblasts (HCO)   
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Human corneal endothelial cells
             Human Trabecular Meshwork Cells (HTMC)   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Sox17-GFP genetically modified stem cells
             H1-GFP   
     
     Fibroblast (Uncategorized)    fully expand to see all 3 entries
             Human Conjunctival Fibroblasts (HConF)   

    See IGFBP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGFBP2

    SOURCE GeneReport for Unigene cluster: Hs.438102
        SABiosciences Custom PCR Arrays for IGFBP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfbp21 , 5 insulin-like growth factor binding protein 21, 5 86.78(n)1
    88.2(a)1
      1 (36.94 cM)5
    160081  NM_008342.31  NP_032368.21 
     728245035 
    chicken
    (Gallus gallus)
    Aves IGFBP21 insulin-like growth factor binding protein 2, 36kDa 75.98(n)
    74.83(a)
      396315  NM_205359.1  NP_990690.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGFBP26
    Uncharacterized protein
    77(a)
    1 ↔ 1
    GL343674.1(93836-98561)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.208832 Xenopus laevis transcribed sequence with moderate similarity more 81.58(n)    BQ897439.1 
    zebrafish
    (Danio rerio)
    Actinopterygii igfbp22 insulin-like growth factor binding protein 2 76.52(n)   30743  AF198033.1 


    ENSEMBL Gene Tree for IGFBP2 (if available)
    TreeFam Gene Tree for IGFBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGFBP2 gene
    IGFBP52  IGFBP12  IGFBP62  IGFBP32  IGFBP42  
    3 SIMAP similar genes for IGFBP2 using alignment to 4 protein entries:     IBP2_HUMAN (see all proteins):
    IGFBP4    IGFBP3    IGFBP1

    IGFBP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/692 SNPs in IGFBP2 are shown (see all 692)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894323561,2
    --209351032(+) TGCCTC/TGGCCT 1 -- us2k10--------
    rs289438701,2
    F--209351134(+) TAACCG/ACCCAT 1 -- us2k112Minor allele frequency- A:0.01NA EU CSAM EA NS MN 1510
    rs1820645011,2
    --209351322(+) TTGGCG/TTCTTA 1 -- us2k10--------
    rs67438781,2
    C,F,H--209351336(+) CCAGGA/TACTTG 1 -- us2k119Minor allele frequency- T:0.01NA MN WA CSA EA 785
    rs93410901,2
    C,F,H--209351467(+) GGGGGG/AAAGAG 1 -- us2k1 trp324Minor allele frequency- A:0.22NS NA EU CSAM EA MN WA 2904
    rs93410911,2
    C,F--209351488(+) GTATAG/AGGAGA 1 -- us2k16Minor allele frequency- A:0.02NS MN 562
    rs360164051,2
    C,F--209351579(+) ACCCCA/CGGAGA 1 -- us2k110Minor allele frequency- C:0.00NA EU CSAM EA MN 788
    rs725472171,2
    F--209351594(+) TGATTA/GTRGCT 1 -- us2k15Minor allele frequency- G:0.01MN 408
    rs725472181,2
    F--209351596(+) ATTRTG/AGCTGA 1 -- us2k15Minor allele frequency- A:0.01MN 408
    rs1481138251,2
    --209351663(+) AAACAG/TAACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IGFBP2 (217497551 - 217529159 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IGFBP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673456CNV Deletion23128226
    esv2721463CNV Deletion23290073
    nsv460098CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 146731    OMIM disorders: --

    20/104 diseases for IGFBP2 (see all 104):    About MalaCards
    malignant ovarian cyst    3-m syndrome    laron syndrome    ovarian cyst
    osteosclerosis    diffuse astrocytoma    retinal ischemia    anaplastic oligodendroglioma
    astrocytoma    uremia    primary pigmented nodular adrenocortical disease    oligodendroglioma
    proliferative diabetic retinopathy    anaplastic astrocytoma    growth hormone deficiency    eating disorder
    renal dysplasia    alveolar rhabdomyosarcoma    androgen insensitivity syndrome    anorexia nervosa

    1 disease from the University of Copenhagen DISEASES database for IGFBP2:
    Prostate cancer

    IGFBP2 for disorders           About GeneDecksing

    10/95 Novoseek inferred disease relationships for IGFBP2 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    growth failure 50.8 1 8792402 (1)
    astrocytoma grade i 49.4 2 16896313 (1), 17285230 (1)
    aml childhood 47.1 2 16444283 (1), 18452107 (1)
    anaplastic oligodendroglioma 46.8 4 19805356 (1), 10485462 (1)
    osteosclerosis 45.3 3 9920116 (1), 12162999 (1)
    growth retardation 45.1 3 11248742 (1), 7581967 (1), 1371449 (1)
    astrocytoma grade ii 40.2 1 19967449 (1)
    hypoglycemia 39.5 4 1697608 (2), 8772589 (1), 12161524 (1)
    prostate cancer 39.4 67 12672024 (7), 12684767 (4), 11821468 (4), 15479293 (4) (see all 27)
    glioma 38.3 79 19164435 (7), 9380278 (5), 19805356 (5), 11250947 (5) (see all 17)

    Genetic Association Database (GAD): IGFBP2
    Human Genome Epidemiology (HuGE) Navigator: IGFBP2 (31 documents)

    Export disorders for IGFBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGFBP2 gene, integrated from 9 sources (see all 734):
    (articles sorted by number of sources associating them with IGFBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia. (PubMed id 1697583)1, 2, 3 Zapf J.... Froesch E.R. (1990)
    2. Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. (PubMed id 19081843)1, 2, 9 Zhou J....Duan C. (2008)
    3. Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. (PubMed id 18210156)1, 4, 9 Garner C.P....Neuhausen S.L. (2008)
    4. Genetic variation in insulin-like growth factor signa ling genes and breast cancer risk among BRCA1 and BRCA2 carriers. (PubMed id 19843326)1, 4, 9 Neuhausen S.L....Gillen D.L. (2009)
    5. Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2). (PubMed id 17020769)1, 2, 9 Kuang Z.... Norton R.S. (2006)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    7. Eighteen insulin-like growth factor pathway genes, ci rculating levels of IGF-I and its binding protein, and risk of prostate and bre ast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (2010)
    8. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    9. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    10. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3485 HGNC: 5471 AceView: IGFBP2 Ensembl:ENSG00000115457 euGenes: HUgn3485
    ECgene: IGFBP2 H-InvDB: IGFBP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGFBP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGFBP2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGFBP2 gene:
    Search GeneIP for patents involving IGFBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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