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Aliases for IGFBP2 Gene

Aliases for IGFBP2 Gene

  • Insulin Like Growth Factor Binding Protein 2 2 3 5
  • Insulin-Like Growth Factor Binding Protein 2, 36kDa 2 3
  • IGF-Binding Protein 2 3 4
  • IBP2 3 4
  • Insulin-Like Growth Factor Binding Protein 2 (36kD) 2
  • Insulin-Like Growth Factor Binding Protein 2 2
  • Insulin-Like Growth Factor-Binding Protein 2 3
  • IGF-BP53 3
  • IGFBP-2 4
  • IBP-2 4
  • BP2 4

External Ids for IGFBP2 Gene

Previous HGNC Symbols for IGFBP2 Gene

  • IBP2

Previous GeneCards Identifiers for IGFBP2 Gene

  • GC02P215595
  • GC02P216219
  • GC02P217462
  • GC02P217700
  • GC02P217323
  • GC02P217206
  • GC02P217497
  • GC02P209352

Summaries for IGFBP2 Gene

Entrez Gene Summary for IGFBP2 Gene

  • The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for IGFBP2 Gene

IGFBP2 (Insulin Like Growth Factor Binding Protein 2) is a Protein Coding gene. Diseases associated with IGFBP2 include Malignant Ovarian Cyst and Pallister-Killian Syndrome. Among its related pathways are Photodynamic therapy-induced HIF-1 survival signaling and Metabolism of proteins. GO annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP4.

UniProtKB/Swiss-Prot for IGFBP2 Gene

  • Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP2 Gene

Genomics for IGFBP2 Gene

Regulatory Elements for IGFBP2 Gene

Enhancers for IGFBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G216533 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.6 -97.2 -97198 4.1 SIN3A FEZF1 ZNF48 ZNF207 FOS ZNF263 KAT8 SSRP1 PBX2 ETV4 IGFBP2 LOC101928180 LOC105373871
GH02G216618 1.4 Ensembl ENCODE dbSUPER 28.6 -12.3 -12343 3.3 HDGF FOXA2 ZNF2 YY1 TCF12 ZNF766 ZNF579 SMARCA4 NBN NR2C1 IGFBP2 SMARCAL1 ENSG00000236886 IGFBP5 PSMB3P2
GH02G216539 1.3 Ensembl ENCODE dbSUPER 20.1 -92.5 -92513 1.7 ELF3 ESRRA FOXA2 JUN MAX RAD21 RARA ZNF664 GATA3 ARID3A IGFBP2 LOC101928180 LOC105373871
GH02G216545 1.3 Ensembl ENCODE dbSUPER 17.6 -86.4 -86355 2.6 HDAC1 ESRRA ATF1 GTF2E2 ETV1 ZNF175 CEBPG FOSL1 TCF12 ZNF766 IGFBP2 LOC101928180 LOC105373871
GH02G216550 1.4 Ensembl ENCODE dbSUPER 16 -80.2 -80178 3.6 ELF3 TBP FOXA2 ARID4B DMAP1 RAD21 RARA CBX5 POLR3A ETV6 IGFBP2 LOC101928180 LOC105373871
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGFBP2 on UCSC Golden Path with GeneCards custom track

Promoters for IGFBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000130098 1772 2801 RAD21 ETS1 GLIS2 EGR2 SP3 ZNF398 ZNF843 SMARCA4 ZNF341 GLIS1

Genomic Location for IGFBP2 Gene

Chromosome:
2
Start:
216,632,828 bp from pter
End:
216,664,436 bp from pter
Size:
31,609 bases
Orientation:
Plus strand

Genomic View for IGFBP2 Gene

Genes around IGFBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP2 Gene

Proteins for IGFBP2 Gene

  • Protein details for IGFBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18065-IBP2_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 2
    Protein Accession:
    P18065
    Secondary Accessions:
    • Q14619
    • Q9UCL3

    Protein attributes for IGFBP2 Gene

    Size:
    325 amino acids
    Molecular mass:
    34814 Da
    Quaternary structure:
    • Binds IGF2 more than IGF1.

    Three dimensional structures from OCA and Proteopedia for IGFBP2 Gene

neXtProt entry for IGFBP2 Gene

Post-translational modifications for IGFBP2 Gene

Other Protein References for IGFBP2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IGFBP2 (IGFBP2)
  • Cloud-Clone Corp. Antibodies for IGFBP2

Assay Products

  • Cloud-Clone Corp Assay Kits for IGFBP2
  • Abcam assays for IGFBP2

No data available for DME Specific Peptides for IGFBP2 Gene

Domains & Families for IGFBP2 Gene

Gene Families for IGFBP2 Gene

Suggested Antigen Peptide Sequences for IGFBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18065

UniProtKB/Swiss-Prot:

IBP2_HUMAN :
  • The C-terminus is required for IGF-binding and growth inhibition.
Domain:
  • The C-terminus is required for IGF-binding and growth inhibition.
genes like me logo Genes that share domains with IGFBP2: view

Function for IGFBP2 Gene

Molecular function for IGFBP2 Gene

GENATLAS Biochemistry:
insulin-like growth factor binding protein 2 ,high affinity,regulator of somatic growth and cellular proliferation,major IGFBP of the spinal fluid expressed by multiple neural tissues,highly expressed in infancy and older age adult,deregulated in pancreatic beta cell tumorigenesis
UniProtKB/Swiss-Prot Function:
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Ontology (GO) - Molecular Function for IGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 24431302
GO:0005515 protein binding IPI 19095771
GO:0005520 insulin-like growth factor binding IEA --
GO:0019838 growth factor binding IEA --
GO:0031994 insulin-like growth factor I binding IDA 19081843
genes like me logo Genes that share ontologies with IGFBP2: view
genes like me logo Genes that share phenotypes with IGFBP2: view

Animal Models for IGFBP2 Gene

MGI Knock Outs for IGFBP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFBP2

miRNA for IGFBP2 Gene

miRTarBase miRNAs that target IGFBP2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP2 Gene

Localization for IGFBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for IGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IDA,ISS 15694994
GO:0016324 apical plasma membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IGFBP2: view

Pathways & Interactions for IGFBP2 Gene

genes like me logo Genes that share pathways with IGFBP2: view

Pathways by source for IGFBP2 Gene

Gene Ontology (GO) - Biological Process for IGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007165 signal transduction IEA --
GO:0007565 female pregnancy IEA --
GO:0007568 aging IEA --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with IGFBP2: view

No data available for SIGNOR curated interactions for IGFBP2 Gene

Drugs & Compounds for IGFBP2 Gene

(37) Drugs for IGFBP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(27) Additional Compounds for IGFBP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP2: view

Transcripts for IGFBP2 Gene

Unigene Clusters for IGFBP2 Gene

Insulin-like growth factor binding protein 2, 36kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for IGFBP2 Gene

GeneLoc Exon Structure for
IGFBP2
ECgene alternative splicing isoforms for
IGFBP2

Expression for IGFBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBP2 Gene

This gene is overexpressed in Artery - Aorta (x8.9), Artery - Coronary (x4.3), and Liver (x4.3).

Protein differential expression in normal tissues from HIPED for IGFBP2 Gene

This gene is overexpressed in Amniocyte (55.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IGFBP2 Gene



Protein tissue co-expression partners for IGFBP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGFBP2 Gene:

IGFBP2

SOURCE GeneReport for Unigene cluster for IGFBP2 Gene:

Hs.438102

Evidence on tissue expression from TISSUES for IGFBP2 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Eye(4.4)
  • Blood(3.1)
  • Muscle(3)
  • Kidney(2.8)
  • Pancreas(2.8)
  • Stomach(2.8)
  • Heart(2.7)
  • Lung(2.6)
  • Spleen(2.4)
  • Intestine(2.3)
  • Adrenal gland(2.1)
  • Thyroid gland(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with IGFBP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP2 Gene

Orthologs for IGFBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBP2 34 35
  • 97.74 (n)
dog
(Canis familiaris)
Mammalia IGFBP2 34 35
  • 93.22 (n)
cow
(Bos Taurus)
Mammalia IGFBP2 34 35
  • 90.86 (n)
mouse
(Mus musculus)
Mammalia Igfbp2 34 16 35
  • 87.21 (n)
rat
(Rattus norvegicus)
Mammalia Igfbp2 34
  • 86.79 (n)
oppossum
(Monodelphis domestica)
Mammalia IGFBP2 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 43 (a)
ManyToMany
chicken
(Gallus gallus)
Aves IGFBP2 34 35
  • 77.53 (n)
lizard
(Anolis carolinensis)
Reptilia IGFBP2 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbp2 34
  • 69.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20883 34
zebrafish
(Danio rerio)
Actinopterygii igfbp2a 34 35
  • 60.08 (n)
igfbp2b 35
  • 49 (a)
OneToMany
igfbp2 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9110 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for IGFBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP2 Gene

ENSEMBL:
Gene Tree for IGFBP2 (if available)
TreeFam:
Gene Tree for IGFBP2 (if available)

Paralogs for IGFBP2 Gene

Paralogs for IGFBP2 Gene

(3) SIMAP similar genes for IGFBP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IGFBP2: view

Variants for IGFBP2 Gene

Sequence variations from dbSNP and Humsavar for IGFBP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000009766 -- 216,646,520(+) TGCTA(A/G)ATGCT intron-variant
rs1000011307 -- 216,650,288(+) ATTTA(C/T)AGATG intron-variant
rs1000028824 -- 216,634,242(+) GACCC(A/G)GACTT intron-variant
rs1000032078 -- 216,639,657(+) ATTTA(C/T)TTCAA intron-variant
rs1000076699 -- 216,647,687(+) GCTAA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFBP2 Gene

Variant ID Type Subtype PubMed ID
esv2673456 CNV deletion 23128226
esv2721463 CNV deletion 23290073
nsv460098 CNV loss 19166990
nsv584454 CNV loss 21841781
nsv584455 CNV loss 21841781

Variation tolerance for IGFBP2 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP2 Gene

Disorders for IGFBP2 Gene

MalaCards: The human disease database

(14) MalaCards diseases for IGFBP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant ovarian cyst
pallister-killian syndrome
  • tetrasomy 12p
insulin-like growth factor i
  • insulin-like growth factor i deficiency
ovarian cyst
  • ovarian cysts
juvenile type testicular granulosa cell tumor
  • juvenile granulosa cell tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGFBP2

Genetic Association Database (GAD)
IGFBP2
Human Genome Epidemiology (HuGE) Navigator
IGFBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFBP2
genes like me logo Genes that share disorders with IGFBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP2 Gene

Publications for IGFBP2 Gene

  1. Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. (PMID: 19081843) Zhou J. … Duan C. (PLoS ONE 2008) 3 4 22 64
  2. Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2). (PMID: 17020769) Kuang Z. … Norton R.S. (J. Mol. Biol. 2006) 3 4 22 64
  3. Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia. (PMID: 1697583) Zapf J. … Froesch E.R. (J. Biol. Chem. 1990) 2 3 4 64
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  5. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64

Products for IGFBP2 Gene

Sources for IGFBP2 Gene

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