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IGFBP2 Gene

protein-coding GIFtS: 68

GC02P217206

insulin-like growth factor binding protein 2, 36kDa
(Previous name: insulin-like growth factor binding protein 2 (36kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IBP2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BP2 ^³
IBP-2 ^³
IBP2 ^², ³
IGF-BP53 ^²
IGFBP-2 ^³

Descriptions
IGF-binding protein 2 ^³
insulin-like growth factor binding protein 2 (36kD) ^¹, ²
insulin-like growth factor binding protein 2, 36kDa ^²

External Ids
HGNC: 5471¹
Entrez Gene: 3485²
UniProtKB: P18065³
Ensembl: ENSG00000115457⁷

Search outside databases for aliases for IGFBP2 gene

Previous GC identifers: GC02P215595 GC02P216219 GC02P217462 GC02P217700 GC02P217323

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: IBP2_HUMAN, P18065

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either

inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the

interaction of IGFs with their cell surface receptors

Gene Wiki entry for IGFBP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IGFBP2 gene

Entrez Gene cytogenetic band: 2q33-q34 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q33-q34

IGFBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P217206: (about GC identifiers)

Start:	217,206,372 bp from pter
End:	217,237,404 bp from pter
Size:	31,033 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IBP2_HUMAN, P18065 (See protein sequence)

Recommended Name: Insulin-like growth factor-binding protein 2 precursor

Size: 328 amino acids; 35138 Da

Subunit: Binds IGF2 more than IGF1

Subcellular location: Secreted

PDB structures from and Proteopedia :

2H7T (3D)

Secondary accessions: Q14619 Q9UCL3

Post-translational modifications:

O-glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000588.2

ENSEMBL proteins:

ENSP00000233809

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for IGFBP2
	R&D Systems Recombinant & Natural Proteins for IGFBP2 (IGFBP-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IGFBP2)
	Human Recombinant Proteins from Abnova (IGFBP2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

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Antibodies for IGFBP2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of IGFBP2
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for IGFBP2 (IGFBP-2)
	Antibodies from Abcam (IGFBP2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IGFBP2)
	Novus Biologicals Antibody for IGFBP2

Assays for IGFBP2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for IGFBP2 (IGFBP-2) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P18065

ProtoNet protein and cluster: P18065

2 Blocks protein families:

IPB000716 Thyroglobulin type-1

IPB000867 Insulin-like growth factor-binding protein

UniProtKB/Swiss-Prot: IBP2_HUMAN, P18065

Similarity: Contains 1 IGFBP N-terminal domain

Similarity: Contains 1 thyroglobulin type-1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGFBP2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000597

Applied Biosystems Silencer® siRNAs for IGFBP2

Sigma-Aldrich siRNA and siRNA Panels for IGFBP2

Sigma-Aldrich shRNA Panels and shRNA for IGFBP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IGFBP2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000597
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000597
untagged cDNA clone in CMV expression vector: NM_000597

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000597

UniProtKB/Swiss-Prot: IBP2_HUMAN, P18065

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either

inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the

interaction of IGFs with their cell surface receptors

Genatlas biochemistry entry for IGFBP2:

insulin-like growth factor binding protein 2 ,high affinity,regulator of somatic growth and

cellular proliferation,major IGFBP of the spinal fluid expressed by multiple neural tissues,highly

expressed in infancy and older age adult,deregulated in pancreatic beta cell tumorigenesis

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Igfbp2):

	hematopoietic system	immune system	liver/biliary system	normal
renal/urinary system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0031994	insulin-like growth factor I binding	IEA	--
GO:0031995	insulin-like growth factor II binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for IGFBP2 (Your Favorite Gene powered by Ingenuity)

IGF-1 Signaling

GeneDecks IGFBP2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for IGFBP2

5/17 Interacting proteins for IGFBP2 (ENSP00000233809³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGF1	ENSP00000302665³	STRING (score=.999)
INS	ENSP00000370731³	STRING (score=.97)
IGF1R	ENSP00000268035³	STRING (score=.946)
IGFALS	ENSP00000215539³	STRING (score=.867)
PTEN	ENSP00000361021³	STRING (score=.862)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0007165	signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for IGFBP2

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IGFBP2
10/39 Novoseek chemical compound relationships for IGFBP2 gene (see all 39 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ribonucleic acid	50.19	7	7519190 (2), 9435438 (2), 8550786 (1), 8949894 (1)
c-peptide	50.04	16	17285578 (4), 11808715 (4), 8887130 (2), 12708727 (1) (see all 9)
androstenedione	42.51	10	11831514 (2), 11906932 (2), 9166698 (2), 14668202 (1) (see all 6)
estradiol	40.53	18	17289850 (3), 11831514 (2), 7508947 (1), 12876417 (1) (see all 13)
procollagen	32.06	6	12201833 (1), 12519882 (1), 9745414 (1), 15546908 (1)
progesterone	31.85	27	1719019 (4), 15809018 (3), 1706350 (2), 11906932 (1) (see all 12)
glucose	26.90	18	18565922 (4), 12496045 (2), 16556765 (2), 16915540 (2) (see all 12)
thymidine	24.88	5	9169346 (2), 15994346 (1), 16684509 (1)
ltd4	19.36	4	8997273 (2)
steroid	17.37	12	1719019 (3), 1706350 (1), 15790698 (1), 1711826 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGFBP2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000597

Sigma-Aldrich siRNA and siRNA Panels for IGFBP2

Sigma-Aldrich shRNA Panels and shRNA for IGFBP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000597

REFSEQ mRNAs for IGFBP2 gene:

NM_000597.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000597

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000597
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000597
                                 untagged cDNA clone in CMV expression vector: NM_000597

Additional cDNA sequence:

AB209509.1 BC004312.1 BC009902.1 BC012769.1 BC071967.1 CR590929.1 CR592781.1 CR593872.1

CR594311.1 CR595316.1 CR596315.1 CR601197.1 CR602232.1 CR603359.1 CR603558.1 CR603833.1

CR605199.1 CR606610.1 CR606726.1 CR606776.1 CR607166.1 CR610845.1 CR611812.1 CR613919.1

CR614828.1 CR617002.1 CR618404.1 CR623237.1 CR624731.1 CR625396.1 CR625740.1 M35410.1

X16302.1

10 DOTS entries:

DT.455798 DT.100641719 DT.100644888 DT.97800939 DT.100715276 DT.97765820 DT.100038198 DT.102831825

DT.121020335 DT.95103302

24/412 AceView cDNA sequences (see all 412 ):

CR606610 CR618404 CR624731 AI817467 BU728144 AA479606 AW161913 BM987735

BF337577 AI401607 BQ226317 CR603359 CR606726 BU168595 BQ218754 AW273491

BG056245 BE464961 AI984402 BG056495 CR605199 CR606776 BU627530 AA035641

highest scoring ESTs for IGFBP2:

X16302 AA028959 AA028960 AA035641 AA035749 AA042827 AA044641 AA045494 AA058887 AA150059

Unigene Cluster for IGFBP2:

Insulin-like growth factor binding protein 2, 36kDa

Hs.438102 [show with all ESTs]

Unigene Representative Sequence: AB209509

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP2

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b
SP1:					-						-
SP2:			-		-						-
SP3:											-
SP4:

About this scheme

ECgene alternative splicing isoforms for IGFBP2

1 Ensembl transcript including schematic representation:

ENST00000233809

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IGFBP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IGFBP2

¹ / ² / ³

4 probe-sets matching IGFBP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40422_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.10	X16302	1.00	1.00	1.00	1
1741_s_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.90	S37730	0.20	1.00	0.72	1
202718_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000597	0.60	1.00	0.82	1
202718_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IGFBP2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCTGTACAA

SOURCE GeneReport for Unigene cluster: Hs.438102
Expression variation in blood from EXPOLDB for IGFBP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IGFBP2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IGFBP2¹	--	insulin-like growth factor binding protein 2, 36kDa	93.31(n) 95.9(a)	488516 XM_545637.2 XP_545637.2
chimpanzee (Pan troglodytes)	IGFBP2¹	--	insulin-like growth factor binding protein 2, 36kDa	99.69(n) 100(a)	460116 XM_516234.2 XP_516234.2
cow (Bos taurus)	IGFBP2¹	--	insulin-like growth factor binding protein 2, 36kDa	90.64(n) 89.59(a)	282260 NM_174555.1 NP_776980.1
rat (Rattus norvegicus)	Igfbp2¹	--	insulin-like growth factor binding protein 2	86.4(n) 89.14(a)	25662 NM_013122.1 NP_037254.1
mouse (Mus musculus)	Igfbp2^{1, 5}	1 (36.10 cM)⁵	insulin-like growth factor binding protein 2^{1, 5}	86.89(n)¹ 88.2(a)¹	16008¹ NM_008342.2¹ NP_032368.2¹ AI255832⁵ AK011784⁵ (see all 14)

About this table Species with no ortholog for IGFBP2

ENSEMBL Gene Tree for IGFBP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IGFBP2 gene

IGFBP1² IGFBP4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/292 NCBI SNPs in IGFBP2 are shown (see all 292 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 147)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6413493^1,2	C,F,H	217237284(+)	`TTCCCC/TGGGGG`	1	--	ut3¹ ese³		15		MN CSAM EA NS EU WA NA	1350
	rs9341228^1,2	C,F,H	217237901(+)	`CACCAC/TTGAGA`	1	--	ng3¹		18		NS EU EA WA NA CSAM	2140
	rs6413492^1,2	C,F,H	217237196(+)	`TATATT/ATGGAA`	1	--	ut3¹		12		MN CSAM EA EU WA NA	962
	rs9341226^1,2	C,F,H	217237770(+)	`AAACRT/CTGGGA`	1	--	ng3¹		11		NS EU EA WA NA CSAM	1558
	rs9341227^1,2	C,F,H	217237876(+)	`TTAACT/CGGCTT`	1	--	ng3¹		16		NS EU EA WA NA CSAM	1620
	rs9341222^1,2	C,F,H	217237655(+)	`GGCGCT/CGTACA`	1	--	ng3¹		10		NS EU EA WA NA CSAM	962
--	rs9341223^1,2	C,F	217237681(+)	`ACGGGC/GTGGGG`	1	--	ng3¹		7		NS NA EU CSAM EA	1158
--	rs9341224^1,2	C,F	217237689(+)	`GGGATG/CGGGAG`	1	--	ng3¹		12		NS NA EU CSAM EA	1204
	rs9496^1,2	C,H	217237199(+)	`ATTTGG/TAAAGA`	1	--	ut3¹		10		MN CSAM EA EU WA	1002
--	rs4672805^1,2	A,C	217204599(+)	`tctctC/Gtgtgt`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for IGFBP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 146731

10/94 Novoseek disease relationships for IGFBP2 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
growth failure	52.01	1	8792402 (1)
astrocytoma grade i	50.83	2	16896313 (1), 17285230 (1)
aml childhood	48.96	2	16444283 (1), 18452107 (1)
growth retardation	43.31	3	11248742 (1), 7581967 (1), 1371449 (1)
anaplastic oligodendroglioma	42.54	2	10485462 (1)
osteosclerosis	40.50	3	9920116 (1), 12162999 (1)
growth hormone deficiency	39.17	5	17223998 (1), 7564158 (1), 8775218 (1), 11150883 (1) (see all 5)
prostate cancer	39.17	63	12672024 (7), 12684767 (4), 11821468 (4), 15479293 (4) (see all 24)
hypoglycemia	38.47	4	1697608 (2), 8772589 (1), 12161524 (1)
atresia	38.03	8	8949894 (3), 9096890 (2), 8612491 (1), 8964586 (1) (see all 5)

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Genetic Association Database: IGFBP2
Human Genome Epidemiology Navigator: IGFBP2 (14 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Team Identifies New Oncogene for Brain Tumors

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/636 PubMed articles for IGFBP2 gene (see all 636 ):

Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia. (PubMed id 1697583)^{2, 3, 4} Zapf J.... Froesch E.R. (1990)
Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2). (PubMed id 17020769)^{1, 3, 4} Kuang Z....Norton R.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structure of the human insulin-like growth factor binding protein-2 gene. (PubMed id 1376411)^{3, 4} Binkert C.... Schwander J. (1992)
Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species. (PubMed id 1726837)^{3, 4} Roghani M.... Binoux M. (1991)
Structure and localization of the human insulin-like growth factor- binding protein 2 gene. (PubMed id 1710112)^{3, 4} Ehrenborg E.... Luthman H. (1991)
Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2). (PubMed id 1712312)^{3, 4} Agarwal N....Swaroop A. (1991)
Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2). (PubMed id 2479552)^{3, 4} Binkert C.... Heinrich G. (1989)
Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects. (PubMed id 1716260)^{1, 3} Clemmons D.R....Busby W.H. (1991)
Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia. (PubMed id 9156044)^{1, 3} Ho P.J. and Baxter R.C. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3485	HGNC: 5471	AceView: IGFBP2	Ensembl:ENSG00000115457	euGenes: HUgn3485
ECgene: IGFBP2	H-InvDB: IGFBP2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IGFBP2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/igfbp2/

Licensable Technologies for IGFBP2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for IGFBP2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IGFBP2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IGFBP2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Proteins for IGFBP2
	Lentivirus-delivered shRNAs for IGFBP2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Drugs for IGFBP2
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Antibodies for IGFBP2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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IGFBP2 Gene at Home site.
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IGFBP2 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for IGFBP2

Summaries
for IGFBP2

Genomic Location
for IGFBP2

Proteins
for IGFBP2

Protein Domains/
Families
for IGFBP2

Gene Function
for IGFBP2

Pathways & Interactions
for IGFBP2

Drugs & Compounds
for IGFBP2

Transcripts
for IGFBP2

Expression
for IGFBP2

Orthologs
for IGFBP2

Paralogs
for IGFBP2

SNPs/Variants
for IGFBP2

Disorders & Mutations
for IGFBP2

Medical News
for IGFBP2

Publications
for IGFBP2

Search for IGFBP2

Genome Databases showing IGFBP2

Other Databases showing IGFBP2

Specialized Databases showing IGFBP2

Licensable Technologies
for IGFBP2

Services
for IGFBP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IGFBP2 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor IGFBP2

Summariesfor IGFBP2

Genomic Locationfor IGFBP2

Proteinsfor IGFBP2

Protein Domains/Familiesfor IGFBP2

Gene Functionfor IGFBP2

Pathways & Interactionsfor IGFBP2

Drugs & Compoundsfor IGFBP2

Transcriptsfor IGFBP2

Expression for IGFBP2

Orthologsfor IGFBP2

Paralogsfor IGFBP2

SNPs/Variantsfor IGFBP2

Disorders & Mutationsfor IGFBP2

Medical Newsfor IGFBP2

Publicationsfor IGFBP2

Search for IGFBP2

Genome Databases showing IGFBP2

Other Databases showing IGFBP2

Specialized Databases showing IGFBP2

Licensable Technologiesfor IGFBP2

Servicesfor IGFBP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IGFBP2

Summaries
for IGFBP2

Genomic Location
for IGFBP2

Proteins
for IGFBP2

Protein Domains/
Families
for IGFBP2

Gene Function
for IGFBP2

Pathways & Interactions
for IGFBP2

Drugs & Compounds
for IGFBP2

Transcripts
for IGFBP2

Expression
for IGFBP2

Orthologs
for IGFBP2

Paralogs
for IGFBP2

SNPs/Variants
for IGFBP2

Disorders & Mutations
for IGFBP2

Medical News
for IGFBP2

Publications
for IGFBP2

Licensable Technologies
for IGFBP2

Services
for IGFBP2