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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGFBP2 Gene

protein-coding GIFtS: 63
GCID: GC02P217497

insulin-like growth factor binding protein 2, 36kDa

(Previous name: insulin-like growth factor binding protein 2 (36kD) )
(Previous symbol: IBP2)

Explore 118 diseases affiliated with
IGFBP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Insulin-Like Growth Factor Binding Protein 2, 36kDa¹ ²		Insulin-Like Growth Factor Binding Protein 2 (36kD)¹
IBP2¹ ² ³		IGF-BP53²
IBP-2² ³		Insulin-Like Growth Factor-Binding Protein 2²
IGFBP-2² ³		BP2³
IGF-Binding Protein 2² ³

External Ids:	HGNC: 5471¹	Entrez Gene: 3485²	Ensembl: ENSG00000115457⁷	OMIM: 146731⁵	UniProtKB: P18065³

Export aliases for IGFBP2 gene to outside databases

Previous GC identifers: GC02P215595 GC02P216219 GC02P217462 GC02P217700 GC02P217323 GC02P217206 GC02P209352

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: IBP2_HUMAN, P18065

Function: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs

and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They

alter the interaction of IGFs with their cell surface receptors

Gene Wiki entry for IGFBP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGFBP2 gene promoter:
CREB PPAR-gamma1 POU2F1 deltaCREB POU2F1a STAT3 PPAR-gamma2 STAT5A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGFBP2 promoter sequence

Search SABiosciences Chromatin IP Primers for IGFBP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q34 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q33-q34

IGFBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P217497: view genomic region (about GC identifiers)

Start:	217,497,551 bp from pter	End:	217,529,159 bp from pter
Size:	31,609 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IBP2_HUMAN, P18065 (See protein sequence)

Recommended Name: Insulin-like growth factor-binding protein 2 precursor

Size: 325 amino acids; 34814 Da

Subunit: Binds IGF2 more than IGF1

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for IGFBP2:

2H7T (3D)

Secondary accessions: Q14619 Q9UCL3

Explore the universe of human proteins at neXtProt for IGFBP2: NX_P18065

Post-translational modifications:

O-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18065

IGFBP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000588.2

ENSEMBL proteins:

ENSP00000401698 ENSP00000233809 ENSP00000389646 ENSP00000400308

Reactome Protein details: P18065
Human Recombinant Protein Products for IGFBP2:

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	Uscn Proteins for IGFBP2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	15694994
GO:0016324	apical plasma membrane	IEA	--
GO:0031410	cytoplasmic vesicle	IEA	--

IGFBP2 for ontologies About GeneDecksing

IGFBP2 Antibody Products:

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	Novus Biologicals IGFBP2 Antibodies
	Abcam antibodies for IGFBP2
	Uscn Antibodies for IGFBP2
	ThermoFisher Antibodies for IGFBP2

Assay Products for IGFBP2:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for IGFBP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IGFBP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGFBP2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000716 Thyroglobulin_1

IPR022321 IGFBP_1-6_chordata

IPR000867 IGFBP-like

IPR012210 IGFBP-2

IPR009168 IGFBP1-6

Graphical View of Domain Structure for InterPro Entry P18065

ProtoNet protein and cluster: P18065

2 Blocks protein families:

IPB000716 Thyroglobulin type-1

IPB000867 Insulin-like growth factor-binding protein

UniProtKB/Swiss-Prot: IBP2_HUMAN, P18065

Domain: The C-terminus is required for IGF-binding and growth inhibition

Similarity: Contains 1 IGFBP N-terminal domain

Similarity: Contains 1 thyroglobulin type-1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IBP2_HUMAN, P18065

Function: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs

and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They

alter the interaction of IGFs with their cell surface receptors

Genatlas biochemistry entry for IGFBP2:

insulin-like growth factor binding protein 2 ,high affinity,regulator of somatic growth and cellular

proliferation,major IGFBP of the spinal fluid expressed by multiple neural tissues,highly expressed in infancy and

older age adult,deregulated in pancreatic beta cell tumorigenesis

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19095771
GO:0005520	insulin-like growth factor binding	--	--
GO:0031994	insulin-like growth factor I binding	IDA	19081843
GO:0031995	insulin-like growth factor II binding	ISS	--

IGFBP2 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for IGFBP2:

Decreased viability of wild-ty

Increased G1 DNA content

Increased gamma-H2AX phosphory

Increased number of mitotic ce

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Igfbp2):

cardiovascular system	hematopoietic system	immune system	liver/biliary system	normal
renal/urinary system

IGFBP2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Igfbp2^tm1Jep for IGFBP2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IGFBP2

miRNA Products:		OriGene 3'-UTR Clone: IGFBP2 Browse MicroRNA Expression Plasmids
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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP2:
		hsa-miR-1250 hsa-miR-130b* hsa-miR-3613-3p hsa-miR-513a-3p hsa-miR-4282 hsa-miR-3667-3p
		SwitchGear 3'UTR luciferase reporter plasmid: IGFBP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFBP2 (see all 7) OriGene shRNA RFP: IGFBP2 OriGene siRNA: IGFBP2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against IGFBP2

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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IGFBP2 (NM_000597)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGFBP2
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		Sirion Biotech Customized stable knockdown cell line services for IGFBP2 Sirion Biotech Customized inducible knockdown cell line services for IGFBP2 Sirion Biotech Customized stable overexpressing cell line services for IGFBP2 Sirion Biotech Customized inducible overexpressing cell line services for IGFBP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development IGF-RI signaling

Development IGF-RI signaling

1.00

Development_IGF-1 receptor signaling

0.99

Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

1.00

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Calcium Regulation in the Cardiac Cell

Myometrial Relaxation and Contraction Pathways

0.43

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for IGFBP2

Development IGF-RI signaling

1 Cell Signaling Technology (CST) Pathway for IGFBP2

Glucose / Energy Metabolism

1 GeneGo (Thomson Reuters) Pathway for IGFBP2

Development IGF-1 receptor signaling

1 BioSystems Pathway for IGFBP2

Myometrial Relaxation and Contraction Pathways

2 Reactome Pathways for IGFBP2

	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	Metabolism of proteins

IGFBP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IGFBP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/8 Interacting proteins for IGFBP2 (P18065^{1, 3} ENSP00000233809⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INO80B	Q9C086¹^,³, ENSP00000233331⁴	EBI-2504392,EBI-715611 I2D: score=1 STRING: ENSP00000233331
IGF1	P05019³, ENSP00000302665⁴	I2D: score=3 STRING: ENSP00000302665
IGF2	P01344³, ENSP00000338297⁴	I2D: score=1 STRING: ENSP00000338297
KLK2	P20151³, ENSP00000313581⁴	I2D: score=1 STRING: ENSP00000313581
TF	P02787³, ENSP00000264998⁴	I2D: score=2 STRING: ENSP00000264998

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0006950	response to stress	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007565	female pregnancy	IEA	--
GO:0007568	aging	IEA	--

IGFBP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IGFBP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGFBP2
10/64 Novoseek chemical compound relationships for IGFBP2 gene (see all 64) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ribonucleic acid	49.3	7	7519190 (2), 9435438 (2), 8550786 (1), 8949894 (1)
c-peptide	48.7	16	17285578 (4), 11808715 (4), 8887130 (2), 12708727 (1) (see all 9)
androstenedione	41.4	10	11831514 (2), 11906932 (2), 9166698 (2), 14668202 (1) (see all 6)
estradiol	41.2	21	17289850 (3), 11831514 (2), 20226513 (2), 7508947 (1) (see all 14)
progesterone	31.5	27	1719019 (4), 15809018 (3), 1706350 (2), 11906932 (1) (see all 12)
procollagen	30.6	6	12201833 (1), 12519882 (1), 9745414 (1), 15546908 (1)
testosterone	29.7	22	20407609 (5), 16368782 (4), 9618803 (1), 7533776 (1) (see all 10)
estrogen	28.8	19	12629097 (3), 15809018 (2), 10992179 (1), 18373644 (1) (see all 13)
glucose	26.8	23	18565922 (4), 19558480 (3), 12496045 (2), 16556765 (2) (see all 14)
thymidine	25.7	5	9169346 (2), 15994346 (1), 16684509 (1)

Search CenterWatch for drugs/clinical trials and news about IGFBP2 / IBP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IGFBP2 gene:

NM_000597.2

Unigene Cluster for IGFBP2:

Insulin-like growth factor binding protein 2, 36kDa

Hs.438102 [show with all ESTs]

Unigene Representative Sequence: AB209509

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000434997 ENST00000233809(uc021vwn.1) ENST00000490362(uc010zju.2)

ENST00000456764 ENST00000436812

miRNA Products:		OriGene 3'-UTR Clone: IGFBP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBP2
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP2:
		hsa-miR-1250 hsa-miR-130b* hsa-miR-3613-3p hsa-miR-513a-3p hsa-miR-4282 hsa-miR-3667-3p
		SwitchGear 3'UTR luciferase reporter plasmid: IGFBP2 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against IGFBP2

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		GenScript: all cDNA clones in your preferred vector: IGFBP2 (NM_000597)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP2

Additional cDNA sequence:

AB209509.1 BC004312.1 BC009902.1 BC012769.1 BC071967.1 M35410.1 X16302.1

10 DOTS entries:

DT.455798 DT.100641719 DT.100644888 DT.100715276 DT.97800939 DT.97765820 DT.100038198 DT.102831825

DT.121020335 DT.95103302

24/412 AceView cDNA sequences (see all 412):

BU627530 AI984402 AI983583 CR606776 AW161913 AI669991 AI401607 BU845432

CN485258 AW151246 BG150531 AI083871 AW590985 CA434747 BM888407 BM888377

CR607166 BE464961 CR623237 BM830070 CR602232 CR625740 BX352848 BQ226317

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP2 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b
SP1:					-						-
SP2:			-		-						-
SP3:											-
SP4:

ECgene alternative splicing isoforms for IGFBP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGFBP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTGTACAA

About this image

IGFBP2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Choroid Plexus

Eye

Inner Nuclear Layer

GABAergic Amacrine Cells

Amacrine, Retina

Brain

Brain

Kidney

Kidney

Diencephalic Ventricular Zone

Neural Tube

Diencephalon

Neural Tube

Reproductive System

Mesonephros

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 9 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Posterior foregut-like cells (A scalable, suspensi...)

See IGFBP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGFBP2

SOURCE GeneReport for Unigene cluster: Hs.438102

SABiosciences Custom PCR Arrays for IGFBP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGFBP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IGFBP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP2 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IGFBP2¹	insulin-like growth factor binding protein 2, 36kDa	75.98(n) 74.83(a)		396315 NM_205359.1 NP_990690.1
lizard (Anolis carolinensis)	Reptilia	IGFBP2⁶	--	73(a)	1 ↔ 1	GL343674.1(93836-98561)
African clawed frog (Xenopus laevis)	Amphibia	Xl.20883²	Xenopus laevis transcribed sequence with moderate similarity more	81.58(n)		BQ897439.1
zebrafish (Danio rerio)	Actinopterygii	igfbp2²	insulin-like growth factor binding protein 2	76.52(n)		30743 AF198033.1

ENSEMBL Gene Tree for IGFBP2 (if available)
TreeFam Gene Tree for IGFBP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGFBP2 gene

IGFBP5² IGFBP1² IGFBP6² IGFBP4² IGFBP3²

3 SIMAP similar genes for IGFBP2 using alignment to 4 protein entries: IBP2_HUMAN (see all proteins):

IGFBP4 IGFBP3 IGFBP1

IGFBP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFBP2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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IGFBP2 for disorders           About GeneDecksing

OMIM gene information: 146731    OMIM disorders: --

20/118 diseases for IGFBP2 (see all 118):    About MalaCards

acid-labile subunit primary pigmented nodular adrenocortical disease growth hormone deficiency 3-m syndrome

proliferative diabetic retinopathy maturity-onset diabetes of the young androgen insensitivity syndrome amyotrophic lateral sclerosis

short stature polycystic ovary syndrome anaplastic oligodendroglioma anorexia nervosa

ovarian cyst type 1 diabetes mellitus diabetic retinopathy eating disorder

diabetes mellitus inflammatory bowel disease severe combined immunodeficiency lateral sclerosis

1 disease from the University of Copenhagen DISEASES database for IGFBP2:

Prostate cancer

10/95 Novoseek disease relationships for IGFBP2 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
growth failure	50.8	1	8792402 (1)
astrocytoma grade i	49.4	2	16896313 (1), 17285230 (1)
aml childhood	47.1	2	16444283 (1), 18452107 (1)
anaplastic oligodendroglioma	46.8	4	19805356 (1), 10485462 (1)
osteosclerosis	45.3	3	9920116 (1), 12162999 (1)
growth retardation	45.1	3	11248742 (1), 7581967 (1), 1371449 (1)
astrocytoma grade ii	40.2	1	19967449 (1)
hypoglycemia	39.5	4	1697608 (2), 8772589 (1), 12161524 (1)
prostate cancer	39.4	67	12672024 (7), 12684767 (4), 11821468 (4), 15479293 (4) (see all 27)
glioma	38.3	79	19164435 (7), 9380278 (5), 19805356 (5), 11250947 (5) (see all 17)

Genetic Association Database (GAD): IGFBP2
Human Genome Epidemiology (HuGE) Navigator: IGFBP2 (31 documents)

Export disorders for IGFBP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IGFBP2 gene, integrated from 9 sources (see all 725):
(articles sorted by number of sources associating them with IGFBP2)

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Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia. (PubMed id 1697583)^{1, 2, 3} Zapf J.... Froesch E.R. (1990)
Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. (PubMed id 19081843)^{1, 2, 9} Zhou J....Duan C. (2008)
Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2). (PubMed id 17020769)^{1, 2, 9} Kuang Z.... Norton R.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structure of the human insulin-like growth factor binding protein-2 gene. (PubMed id 1376411)^{1, 2} Binkert C.... Schwander J. (1992)
Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species. (PubMed id 1726837)^{1, 2} Roghani M.... Binoux M. (1991)
Structure and localization of the human insulin-like growth factor- binding protein 2 gene. (PubMed id 1710112)^{1, 2} Ehrenborg E.... Luthman H. (1991)
Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2). (PubMed id 1712312)^{1, 2} Agarwal N....Swaroop A. (1991)
Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2). (PubMed id 2479552)^{1, 2} Binkert C.... Heinrich G. (1989)
Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects. (PubMed id 1716260)^{1, 9} Clemmons D.R....Busby W.H. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3485	HGNC: 5471	AceView: IGFBP2	Ensembl:ENSG00000115457	euGenes: HUgn3485
ECgene: IGFBP2	H-InvDB: IGFBP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IGFBP2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IGFBP2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/igfbp2/

Intellectual Property for IGFBP2 gene
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Patent Information for IGFBP2 gene:
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IGFBP2 Gene

insulin-like growth factor binding protein 2, 36kDa

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LUNG TUMOR
Anaplastic Oligodendroglioma
Hyperinsulinemia
Retinoblastoma
sepsis
Eating Disorders
Ovarian Cysts
aggressiveness
COLON CARCINOMA
Anaplastic Astrocytoma
insulin sensitivity
Ischemia
Breast Cancer
Hypoglycemia
Adenocarcinoma
AIDS
Nephrotic Syndrome
Cancer
Diabetes Mellitus Insulin-Dependent
premalignant
Meningitis
GASTRIC CARCINOMA
RENAL DISEASE
Shock
Ovarian Cancer
Liver Failure
Colorectal Cancer
Multiple Sclerosis
Malnutrition
glomerulosclerosis
CNS tumors
SHORT STATURE
Cysts
Hepatitis
Hypertrophy
Renal Failure
Astrocytoma Grade II
Osteopenia
prostate cancer
Tumors
Metastasis
prostatic adenocarcinoma
Atresia
Lymphoblastic Leukemia Acute
Necrosis
Glioblastoma
COLON TUMOR
progressive disease
Gastric Cancer
Glioblastoma Multiforme
BREAST CARCINOMA
Brain Tumors
Melanoma
bladder cancer
Colon Cancer
Anorexia Nervosa
Hyperplasia
Glioma
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Carcinoma
Astrocytoma
Osteoarthritis
ACUTE LEUKEMIA
Leukemia
PROSTATE CARCINOMA
Acromegaly
Diabetes Mellitus
Osteoporosis
Growth failure
Amyotrophic Lateral Sclerosis
Intrauterine Growth Retardation
Cancer Lung
small cell lung cancer
Uremia
Inflammatory Bowel Diseases
Carcinoma Adrenocortical
Adrenocortical Cancer
Proliferative diabetic retinopathy
growth hormone deficiency
Insulin Resistance
Adenoma
benign prostatic hyperplasia
OVARIAN CARCINOMA
Prostatic Intraepithelial Neoplasia
Astrocytoma Grade I
OBESITY
Osteosclerosis
Polycystic Ovary Syndrome
solid tumor
Retinal ischemia
AML childhood
Growth retardation
Polycystic ovaries
Endometrial Cancer
Renal Failure Chronic

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IGFBP2 Gene

insulin-like growth factor binding protein 2, 36kDa

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