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Aliases for IGFBP2 Gene

Aliases for IGFBP2 Gene

  • Insulin-Like Growth Factor Binding Protein 2, 36kDa 2 3
  • IGF-Binding Protein 2 3 4
  • IGFBP-2 3 4
  • IBP-2 3 4
  • IBP2 3 4
  • Insulin-Like Growth Factor Binding Protein 2 (36kD) 2
  • Insulin-Like Growth Factor-Binding Protein 2 3
  • IGF-BP53 3
  • BP2 4

External Ids for IGFBP2 Gene

Previous HGNC Symbols for IGFBP2 Gene

  • IBP2

Previous GeneCards Identifiers for IGFBP2 Gene

  • GC02P215595
  • GC02P216219
  • GC02P217462
  • GC02P217700
  • GC02P217323
  • GC02P217206
  • GC02P217497
  • GC02P209352

Summaries for IGFBP2 Gene

GeneCards Summary for IGFBP2 Gene

IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa) is a Protein Coding gene. Diseases associated with IGFBP2 include malignant ovarian cyst and insulin-like growth factor i. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Glucose / Energy Metabolism. GO annotations related to this gene include insulin-like growth factor I binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP4.

UniProtKB/Swiss-Prot for IGFBP2 Gene

  • Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP2 Gene

Genomics for IGFBP2 Gene

Regulatory Elements for IGFBP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IGFBP2 Gene

Start:
216,632,828 bp from pter
End:
216,664,436 bp from pter
Size:
31,609 bases
Orientation:
Plus strand

Genomic View for IGFBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGFBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP2 Gene

Proteins for IGFBP2 Gene

  • Protein details for IGFBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18065-IBP2_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 2
    Protein Accession:
    P18065
    Secondary Accessions:
    • Q14619
    • Q9UCL3

    Protein attributes for IGFBP2 Gene

    Size:
    325 amino acids
    Molecular mass:
    34814 Da
    Quaternary structure:
    • Binds IGF2 more than IGF1

    Three dimensional structures from OCA and Proteopedia for IGFBP2 Gene

neXtProt entry for IGFBP2 Gene

Proteomics data for IGFBP2 Gene at MOPED

Post-translational modifications for IGFBP2 Gene

Other Protein References for IGFBP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IGFBP2 (IGFBP2)

Protein Products

No data available for DME Specific Peptides for IGFBP2 Gene

Domains for IGFBP2 Gene

Suggested Antigen Peptide Sequences for IGFBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18065

UniProtKB/Swiss-Prot:

IBP2_HUMAN :
  • P18065
Domain:
  • The C-terminus is required for IGF-binding and growth inhibition.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with IGFBP2: view

No data available for Gene Families for IGFBP2 Gene

Function for IGFBP2 Gene

Molecular function for IGFBP2 Gene

GENATLAS Biochemistry: insulin-like growth factor binding protein 2 ,high affinity,regulator of somatic growth and cellular proliferation,major IGFBP of the spinal fluid expressed by multiple neural tissues,highly expressed in infancy and older age adult,deregulated in pancreatic beta cell tumorigenesis
UniProtKB/Swiss-Prot Function: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Ontology (GO) - Molecular Function for IGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19095771
GO:0005520 insulin-like growth factor binding --
GO:0031994 insulin-like growth factor I binding IDA 19081843
GO:0031995 insulin-like growth factor II binding ISS --
genes like me logo Genes that share ontologies with IGFBP2: view
genes like me logo Genes that share phenotypes with IGFBP2: view

Animal Models for IGFBP2 Gene

MGI Knock Outs for IGFBP2:

Animal Model Products

CRISPR Products

miRNA for IGFBP2 Gene

miRTarBase miRNAs that target IGFBP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IGFBP2 Gene

Localization for IGFBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFBP2 Gene COMPARTMENTS Subcellular localization image for IGFBP2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 15694994
GO:0016324 apical plasma membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IGFBP2: view

Pathways for IGFBP2 Gene

genes like me logo Genes that share pathways with IGFBP2: view

Pathways by source for IGFBP2 Gene

1 Cell Signaling Technology pathway for IGFBP2 Gene
1 BioSystems pathway for IGFBP2 Gene

Gene Ontology (GO) - Biological Process for IGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007165 signal transduction IEA --
GO:0007565 female pregnancy IEA --
GO:0007568 aging IEA --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with IGFBP2: view

Compounds for IGFBP2 Gene

(64) Novoseek inferred chemical compound relationships for IGFBP2 Gene

Compound -log(P) Hits PubMed IDs
ribonucleic acid 49.3 6
c-peptide 48.7 16
androstenedione 41.4 9
estradiol 41.2 18
progesterone 31.5 18
genes like me logo Genes that share compounds with IGFBP2: view

Transcripts for IGFBP2 Gene

Unigene Clusters for IGFBP2 Gene

Insulin-like growth factor binding protein 2, 36kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFBP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for IGFBP2 Gene

GeneLoc Exon Structure for
IGFBP2
ECgene alternative splicing isoforms for
IGFBP2

Expression for IGFBP2 Gene

mRNA expression in normal human tissues for IGFBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBP2 Gene

This gene is overexpressed in Artery - Aorta (8.9), Artery - Coronary (4.3), and Liver (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGFBP2 Gene

SOURCE GeneReport for Unigene cluster for IGFBP2 Gene Hs.438102

genes like me logo Genes that share expressions with IGFBP2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IGFBP2 Gene

Orthologs for IGFBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBP2 35
  • 97.74 (n)
  • 97.23 (a)
IGFBP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGFBP2 35
  • 90.86 (n)
  • 91.32 (a)
IGFBP2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGFBP2 35
  • 93.22 (n)
  • 95.93 (a)
IGFBP2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igfbp2 35
  • 87.21 (n)
  • 89.3 (a)
Igfbp2 16
Igfbp2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFBP2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Igfbp2 35
  • 86.79 (n)
  • 90 (a)
chicken
(Gallus gallus)
Aves IGFBP2 35
  • 77.53 (n)
  • 76.92 (a)
IGFBP2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGFBP2 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20883 35
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbp2 35
  • 69.48 (n)
  • 67.43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9110 35
zebrafish
(Danio rerio)
Actinopterygii igfbp2 35
igfbp2a 35
  • 60.08 (n)
  • 56.79 (a)
igfbp2a 36
  • 53 (a)
OneToMany
igfbp2b 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for IGFBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP2 Gene

ENSEMBL:
Gene Tree for IGFBP2 (if available)
TreeFam:
Gene Tree for IGFBP2 (if available)

Paralogs for IGFBP2 Gene

Paralogs for IGFBP2 Gene

Selected SIMAP similar genes for IGFBP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IGFBP2: view

Variants for IGFBP2 Gene

Sequence variations from dbSNP and Humsavar for IGFBP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_018871 -

Structural Variations from Database of Genomic Variants (DGV) for IGFBP2 Gene

Variant ID Type Subtype PubMed ID
esv2673456 CNV Deletion 23128226
esv2721463 CNV Deletion 23290073
nsv460098 CNV Loss 19166990

Relevant External Links for IGFBP2 Gene

HapMap Linkage Disequilibrium report
IGFBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP2 Gene

Disorders for IGFBP2 Gene

(1) University of Copenhagen DISEASES for IGFBP2 Gene

(95) Novoseek inferred disease relationships for IGFBP2 Gene

Disease -log(P) Hits PubMed IDs
growth failure 50.8 1
astrocytoma grade i 49.4 2
aml childhood 47.1 2
anaplastic oligodendroglioma 46.8 2
osteosclerosis 45.3 2

Relevant External Links for IGFBP2

Genetic Association Database (GAD)
IGFBP2
Human Genome Epidemiology (HuGE) Navigator
IGFBP2
genes like me logo Genes that share disorders with IGFBP2: view

No data available for UniProtKB/Swiss-Prot for IGFBP2 Gene

Publications for IGFBP2 Gene

  1. Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2). (PMID: 17020769) Kuang Z. … Norton R.S. (J. Mol. Biol. 2006) 3 4 23
  2. Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. (PMID: 19081843) Zhou J. … Duan C. (PLoS ONE 2008) 3 4 23
  3. Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. (PMID: 18210156) Garner C.P. … Neuhausen S.L. (Hum. Genet. 2008) 3 23 48
  4. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers. (PMID: 19843326) Neuhausen S.L. … Gillen D.L. (Breast Cancer Res. 2009) 3 23 48
  5. Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia. (PMID: 1697583) Zapf J. … Froesch E.R. (J. Biol. Chem. 1990) 2 3 4

Products for IGFBP2 Gene

Sources for IGFBP2 Gene

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