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IGFBP1 Gene

protein-coding GIFtS: 65

GC07P045894

insulin-like growth factor binding protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IBP1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AFBP ^¹, ²
IBP-1 ^³
IBP1 ^², ³
IGF-BP25 ^¹, ²
IGFBP-1 ^³
PP12 ^¹, ², ³
hIGFBP-1 ^¹, ²

Descriptions
IGF-binding protein 1 ^², ³
Placental protein 12 ^², ³
alpha-pregnancy-associated endometrial globulin ^²
amniotic fluid binding protein ^²
binding protein-25 ^²
binding protein-26 ^²
binding protein-28 ^²
growth hormone independent-binding protein ^²
insulin-like growth factor binding protein 1 ^²

External Ids
HGNC: 5469¹
Entrez Gene: 3484²
UniProtKB: P08833³
Ensembl: ENSG00000146678⁷

Search outside databases for aliases for IGFBP1 gene

Previous GC identifers: GC07P045574 GC07P045668 GC07P045701

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IGFBP1:

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes

a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both

insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein

prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

[provided by RefSeq]

UniProtKB/Swiss-Prot: IBP1_HUMAN, P08833

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either

inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the

interaction of IGFs with their cell surface receptors. Promotes cell migration

Gene Wiki entry for IGFBP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IGFBP1 gene

Entrez Gene cytogenetic band: 7p13-p12 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13-p12

IGFBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P045894: (about GC identifiers)

Start:	45,894,484 bp from pter
End:	45,899,792 bp from pter
Size:	5,309 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 45,967,292-45,972,600

RefSeq DNA sequence:

NC_000007.12 NT_007819.16 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IBP1_HUMAN, P08833 (See protein sequence)

Recommended Name: Insulin-like growth factor-binding protein 1 precursor

Size: 259 amino acids; 27904 Da

Subunit: Binds equally well IGF1 and IGF2

Subcellular location: Secreted

Sequence caution: Sequence=AAA52540.1; Type=Frameshift; Positions=55, 71;

PDB structures from and Proteopedia :

1ZT3 (3D)

1ZT5 (3D)

2DSQ (3D)

Secondary accessions: Q8IYP5

Post-translational modifications:

Phosphorylated; probably by casein kinase II. Alters the affinity of the protein for IGFs¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000587.1

ENSEMBL proteins:

ENSP00000275525

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IGFBP1 (IGFBP-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IGFBP1)
	Human Recombinant Proteins from Abnova (IGFBP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	2454104

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Antibodies for IGFBP1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of IGFBP1
	Sigma-Aldrich Antibodies for IGFBP1
	R&D Systems Antibodies for IGFBP1 (IGFBP-1)
	Antibodies from Abcam (IGFBP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IGFBP1)
	Novus Biologicals Antibodies for IGFBP1

Assays for IGFBP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for IGFBP1 (IGFBP-1) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08833

ProtoNet protein and cluster: P08833

2 Blocks protein families:

IPB000716 Thyroglobulin type-1

IPB000867 Insulin-like growth factor-binding protein

UniProtKB/Swiss-Prot: IBP1_HUMAN, P08833

Similarity: Contains 1 IGFBP N-terminal domain

Similarity: Contains 1 thyroglobulin type-1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGFBP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IGFBP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001013029

Sigma-Aldrich siRNA and siRNA Panels for IGFBP1

Sigma-Aldrich shRNA for IGFBP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IGFBP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000596
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000596
untagged cDNA clones in CMV expression vector (see all 2): NM_000596

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000596

UniProtKB/Swiss-Prot: IBP1_HUMAN, P08833

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either

inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the

interaction of IGFs with their cell surface receptors. Promotes cell migration

Genatlas biochemistry entry for IGFBP1:

insulin-like growth factor binding protein 1,high affinity,expressed in liver, decidua,kidney and

in amniotic fluid,regulator of somatic growth and cellular proliferation,regulated by insulin and

corticoids,duplicated in an atypical Silver Russel syndrome

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Igfbp1):

cellular

immune system

liver/biliary system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005520	insulin-like growth factor binding	TAS	2454104

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for IGFBP1 (Your Favorite Gene powered by Ingenuity)

Estrogen Receptor Signaling
PXR/RXR Activation
IGF-1 Signaling
VDR/RXR Activation

GeneDecks IGFBP1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IGFBP1

5/22 Interacting proteins for IGFBP1 (ENSP00000275525³) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGF1	ENSP00000302665³	STRING (score=.999)
INS	ENSP00000370731³	STRING (score=.998)
FOXO1	ENSP00000368880³	STRING (score=.973)
FOXA2	ENSP00000366319³	STRING (score=.962)
NR3C1	ENSP00000231509³	STRING (score=.945)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0007165	signal transduction	TAS	2454104

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for IGFBP1

Sigma-Aldrich Small Molecules for IGFBP1:

Inhibitor

Browse Tocris compounds for IGFBP1
10/46 Novoseek chemical compound relationships for IGFBP1 gene (see all 46 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pp-12	83.87	17	2318953 (7), 7530848 (2), 1534990 (2), 1840727 (1) (see all 7)
c-peptide	71.45	85	17285578 (4), 11524238 (4), 11808715 (4), 19064975 (3) (see all 47)
glucose	69.67	453	9170816 (7), 7693379 (6), 9284705 (5), 9283794 (5) (see all 99)
progesterone	62.91	115	12843192 (9), 8915665 (4), 15501902 (3), 17585572 (3) (see all 55)
estradiol	62.48	62	17484513 (3), 15713723 (2), 16891052 (2), 11075292 (2) (see all 40)
dehydroepiandrosterone sulfate	58.75	24	10561001 (3), 9595787 (2), 7561622 (2), 10407219 (1) (see all 15)
androstenedione	57.26	23	7534218 (2), 7516827 (2), 9359637 (2), 14557441 (1) (see all 16)
pegvisomant	49.62	4	19075184 (1), 14700556 (1)
dhea	42.38	18	8548945 (3), 11826868 (2), 10407219 (1), 16497451 (1) (see all 8)
ribonucleic acid	42.32	5	8772565 (1), 10946870 (1), 7693517 (1), 8675593 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGFBP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IGFBP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001013029

Sigma-Aldrich siRNA and siRNA Panels for IGFBP1

Sigma-Aldrich shRNA for IGFBP1

Explore Sigma-Aldrich super-pooled esiRNAs

REFSEQ mRNAs for IGFBP1 gene:

NM_000596.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000596

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000596
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000596
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000596

Additional cDNA sequence:

AF042356.1 AK314925.1 BC035263.1 BC057806.1 BT019685.1 CR590296.1 CR590446.1 CR590810.1

CR590828.1 CR591020.1 CR591191.1 CR591333.1 CR591460.1 CR591493.1 CR591523.1 CR591646.1

CR592108.1 CR592210.1 CR592395.1 CR592435.1 CR592564.1 CR592840.1 CR592847.1 CR593064.1

CR593140.1 CR593474.1 CR593624.1 CR593681.1 CR593730.1 CR593732.1 CR593890.1 CR594263.1

CR594657.1 CR594876.1 CR594968.1 CR594970.1 CR594981.1 CR595235.1 CR595308.1 CR595377.1

CR595563.1 CR595722.1 CR595849.1 CR595859.1 CR595923.1 CR595943.1 CR595981.1 CR596031.1

CR596115.1 CR596125.1 CR596242.1 CR596353.1 CR596942.1 CR596959.1 CR596968.1 CR597423.1

CR597823.1 CR597836.1 CR597884.1 CR597940.1 CR598148.1 CR598241.1 CR598358.1 CR598506.1

CR598846.1 CR598858.1 CR599338.1 CR599420.1 CR599505.1 CR599566.1 CR599693.1 CR599844.1

CR599914.1 CR600017.1 CR600132.1 CR600152.1 CR600677.1 CR600719.1 CR600747.1 CR600995.1

CR601164.1 CR601177.1 CR601473.1 CR601666.1 CR601760.1 CR602010.1 CR602077.1 CR602114.1

CR602158.1 CR602198.1 CR602277.1 CR602289.1 CR602661.1 CR602679.1 CR602685.1 CR603126.1

CR603129.1 CR603353.1 CR603560.1 CR603667.1 CR603723.1 CR603912.1 CR603923.1 CR604704.1

CR604841.1 CR605002.1 CR605113.1 CR605273.1 CR605451.1 CR605700.1 CR605762.1 CR605866.1

CR606006.1 CR606011.1 CR606129.1 CR606400.1 CR606620.1 CR606723.1 CR606856.1 CR606977.1

CR607108.1 CR607209.1 CR607229.1 CR607276.1 CR607496.1 CR607533.1 CR608231.1 CR608409.1

CR608815.1 CR609672.1 CR609679.1 CR609741.1 CR609768.1 CR609939.1 CR609990.1 CR610214.1

CR610351.1 CR610645.1 CR610858.1 CR610941.1 CR611438.1 CR611759.1 CR611770.1 CR611935.1

CR611997.1 CR612513.1 CR612646.1 CR612764.1 CR613214.1 CR613237.1 CR613310.1 CR613347.1

CR613395.1 CR614129.1 CR614193.1 CR614258.1 CR614303.1 CR614704.1 CR614706.1 CR614863.1

CR615008.1 CR615190.1 CR615567.1 CR615815.1 CR615923.1 CR616079.1 CR616205.1 CR616234.1

CR616235.1 CR616351.1 CR616402.1 CR616424.1 CR616577.1 CR616674.1 CR616903.1 CR616959.1

CR617244.1 CR617631.1 CR617806.1 CR617824.1 CR617913.1 CR617981.1 CR618103.1 CR618173.1

CR618294.1 CR618587.1 CR618725.1 CR618802.1 CR618972.1 CR619099.1 CR619129.1 CR619351.1

CR619516.1 CR619548.1 CR619565.1 CR619689.1 CR619896.1 CR619910.1 CR619921.1 CR620024.1

CR620278.1 CR620526.1 CR620546.1 CR621001.1 CR621476.1 CR621807.1 CR621967.1 CR621982.1

CR622062.1 CR622288.1 CR622311.1 CR622795.1 CR623462.1 CR623910.1 CR623952.1 CR624055.1

CR624100.1 CR624572.1 CR625190.1 CR625230.1 CR625382.1 CR625425.1 CR625430.1 CR625453.1

CR625654.1 CR625677.1 CR625686.1 CR625906.1 CR625916.1 CR625929.1 CR626019.1 CR626184.1

CR626214.1 CR626313.1 CR626530.1 CR626753.1 CR626850.1 M20841.1 M31145.1 X12385.1

X13405.1 X15002.1 Y00856.1

24/28 DOTS entries (see all 28 ):

DT.100891915 DT.219024 DT.95263421 DT.100762376 DT.100891936 DT.100891833 DT.100891882 DT.100761213

DT.95367679 DT.91724975 DT.100891850 DT.100891932 DT.449084 DT.104575 DT.91673738 DT.92453318

DT.95298483 DT.100699965 DT.100891871 DT.100891905 DT.100891916 DT.100891922 DT.100891924 DT.100891949

24/981 AceView cDNA sequences (see all 981 ):

CR600719 CR601666 BX339398 CR616674 BX377599 CR611438 CR625430 CR596242

CR611935 CR596959 CR625686 CR607533 CR592435 CR615815 CR613347 CR619921

BX378865 BX403382 CR597423 CR618972 AI375873 CR597836 CR593681 CR605762

highest scoring ESTs for IGFBP1:

AA026337 AA035491 AA043954 AA043966 AA046598 AA046726 AA098889 AA099914 AA101982 AA102110

Unigene Cluster for IGFBP1:

Insulin-like growth factor binding protein 1

Hs.642938 [show with all ESTs]

Unigene Representative Sequence: NM_000596

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000275525

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IGFBP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IGFBP1

¹ / ² / ³

3 probe-sets matching IGFBP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1232_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M74587	0.20	1.00	0.72	1
205302_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000596	0.60	1.00	0.82	1
205302_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IGFBP1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAAAATACT

SOURCE GeneReport for Unigene cluster: Hs.642938
Expression variation in blood from EXPOLDB for IGFBP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IGFBP1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IGFBP1¹	--	insulin-like growth factor binding protein 1	72.43(n) 66.26(a)	480812 XM_537927.2 XP_537927.2
chimpanzee (Pan troglodytes)	IGFBP1¹	--	insulin-like growth factor binding protein 1	99.33(n) 98.48(a)	463395 XM_519083.2 XP_519083.2
rat (Rattus norvegicus)	Igfbp1¹	--	insulin-like growth factor binding protein 1	74.93(n) 72.8(a)	25685 NM_013144.1 NP_037276.1
mouse (Mus musculus)	Igfbp1^{1, 5}	11 (1.30 cM)⁵	insulin-like growth factor binding protein 1^{1, 5}	75.47(n)¹ 71.2(a)¹	16006¹ NM_008341.3¹ NP_032367.2¹ AA060360⁵ AI256511⁵ (see all 11)
chicken (Gallus gallus)	IGFBP1¹	--	insulin-like growth factor binding protein 1	61.56(n) 54.84(a)	408027 NM_001001294.1 NP_001001294.1

About this table Species with no ortholog for IGFBP1

ENSEMBL Gene Tree for IGFBP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IGFBP1 gene

IGFBP2² IGFBP4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/85 NCBI SNPs in IGFBP1 are shown (see all 85 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4619^1,2	A,C,F,H,O	45899194(+)	`CAGATA/GTATTT`	1	I/M	mis¹		26	MN EU EA WA NS NA	2728
	rs1908750^1,2	C,F,H,O	45899605(+)	`AGGACG/AGTTAA`	1	--	ut3¹ ese³		8	NS EU EA WA NA	736
	rs1065780^1,2	A,C,F,H	45894202(+)	`TCTGCG/ATTTGA`	1	--	ng5¹		14	EU EA WA NS NA	1468
	rs9658231^1,2	C,F,H	45899949(+)	`GGCTGC/ACCCAG`	1	--	ng3¹		16	NS EU EA WA NA	1706
	rs7454^1,2	C,F,H	45899531(+)	`AAGAGC/GATGGA`	1	--	ut3¹		15	NS MN EU EA WA NA	1662
--	rs41258845^1,2	C,F	45895116(+)	`CTCCCC/GATGCT`	1	H/D	mis¹		1	NA	158
	rs9658232^1,2	F,H	45900075(+)	`TCTTGG/ATTTGG`	1	--	ng3¹		5	NS EU EA WA	582
--	rs1052652^1,2	C,F	45899319(+)	`ATATAT/CAGTAA`	1	--	ut3¹		2	MN NA	228
	rs1065782^1,2	C,H	45898083(+)	`ACAGAG/ATCGTA`	1	I/V	mis¹ ese³		6	NS MN EU EA WA	760
	rs9658233^1,2	F,H	45900266(+)	`CCCTGA/TTTGCA`	1	--	ng3¹		5	NS EU EA WA	588

About this table

HapMap Linkage Disequilibrium images for IGFBP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 146730

10/94 Novoseek disease relationships for IGFBP1 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin sensitivity	71.86	68	7593430 (5), 10396366 (3), 15598684 (3), 9032568 (2) (see all 43)
insulin resistance	70.50	79	1375600 (3), 14687242 (2), 11028691 (2), 7693379 (2) (see all 54)
polycystic ovary syndrome	68.03	16	1283982 (2), 7516827 (2), 8671313 (1), 11569168 (1) (see all 8)
growth failure	64.50	7	1280613 (2), 8792402 (1), 9048593 (1), 9402139 (1) (see all 5)
hyperinsulinemia	63.42	33	8954066 (2), 10868969 (1), 19158202 (1), 7507119 (1) (see all 26)
hyperandrogenism	63.38	8	7589662 (1), 12477526 (1), 15063962 (1), 17709876 (1) (see all 7)
growth retardation	60.26	17	12489207 (3), 16809446 (2), 7531120 (1), 8636264 (1) (see all 12)
fetal hypoxia	57.25	5	8821897 (1), 10946870 (1), 9707622 (1), 7532055 (1)
intrauterine growth retardation	54.41	24	16809446 (2), 7532055 (2), 8989275 (1), 12489207 (1) (see all 15)
diabetes mellitus insulin-dependent	53.45	23	12153746 (2), 7530621 (2), 7534144 (2), 11392040 (1) (see all 17)

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Human Gene Mutation Database: IGFBP1
Human Genome Epidemiology Navigator: IGFBP1 (22 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1097 PubMed articles for IGFBP1 gene (see all 1097 ):

Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1). (PubMed id 2461294)^{2, 3, 4} Brinkman A.... Drop S.L.S. (1988)
The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry. (PubMed id 10329650)^{1, 3, 4} Neumann G.M. and Bach L.A. (1999)
Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. (PubMed id 16924115)^{1, 3, 4} Sitar T.... Holak T.A. (2006)
Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid. (PubMed id 15972819)^{3, 4} Sala A....Monaco H.L. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101. (PubMed id 7678248)^{3, 4} Jones J.I....Clemmons D.R. (1993)
Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7. (PubMed id 1373120)^{3, 4} Ehrenborg E....Luthman H. (1992)
Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability. (PubMed id 1718783)^{3, 4} Brinkman A....Drop S.L.S. (1991)
Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein. (PubMed id 2474129)^{3, 4} Cubbage M.L.... Powell D.R. (1989)
Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning. (PubMed id 2466665)^{3, 4} Luthman H.... Joernvall H. (1989)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3484	HGNC: 5469	AceView: IGFBP1	Ensembl:ENSG00000146678	euGenes: HUgn3484
ECgene: IGFBP1	H-InvDB: IGFBP1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for IGFBP1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/igfbp1/

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IGFBP1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for IGFBP1

Summaries
for IGFBP1

Genomic Location
for IGFBP1

Proteins
for IGFBP1

Protein Domains/
Families
for IGFBP1

Gene Function
for IGFBP1

Pathways & Interactions
for IGFBP1

Drugs & Compounds
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Transcripts
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Expression
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Genome Databases showing IGFBP1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IGFBP1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor IGFBP1

Summariesfor IGFBP1

Genomic Locationfor IGFBP1

Proteinsfor IGFBP1

Protein Domains/Familiesfor IGFBP1

Gene Functionfor IGFBP1

Pathways & Interactionsfor IGFBP1

Drugs & Compoundsfor IGFBP1

Transcriptsfor IGFBP1

Expression for IGFBP1

Orthologsfor IGFBP1

Paralogsfor IGFBP1

SNPs/Variantsfor IGFBP1

Disorders & Mutationsfor IGFBP1

Medical Newsfor IGFBP1

Publicationsfor IGFBP1

Search for IGFBP1

Genome Databases showing IGFBP1

Other Databases showing IGFBP1

Specialized Databases showing IGFBP1

Licensable Technologiesfor IGFBP1

Servicesfor IGFBP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IGFBP1

Summaries
for IGFBP1

Genomic Location
for IGFBP1

Proteins
for IGFBP1

Protein Domains/
Families
for IGFBP1

Gene Function
for IGFBP1

Pathways & Interactions
for IGFBP1

Drugs & Compounds
for IGFBP1

Transcripts
for IGFBP1

Expression
for IGFBP1

Orthologs
for IGFBP1

Paralogs
for IGFBP1

SNPs/Variants
for IGFBP1

Disorders & Mutations
for IGFBP1

Medical News
for IGFBP1

Publications
for IGFBP1

Licensable Technologies
for IGFBP1

Services
for IGFBP1