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Aliases for IGFBP1 Gene

Aliases for IGFBP1 Gene

  • Insulin-Like Growth Factor Binding Protein 1 2 3
  • IGF-Binding Protein 1 2 3 4
  • Placental Protein 12 2 3 4
  • Alpha-Pregnancy-Associated Endometrial Globulin 2 3
  • Growth Hormone Independent-Binding Protein 2 3
  • Amniotic Fluid Binding Protein 2 3
  • Binding Protein-28 2 3
  • Binding Protein-26 2 3
  • Binding Protein-25 2 3
  • IGFBP-1 3 4
  • IBP-1 3 4
  • IBP1 3 4
  • PP12 3 4
  • Insulin-Like Growth Factor-Binding Protein 1 3
  • IGF-BP25 3
  • HIGFBP-1 3
  • AFBP 3

External Ids for IGFBP1 Gene

Previous HGNC Symbols for IGFBP1 Gene

  • IBP1

Previous GeneCards Identifiers for IGFBP1 Gene

  • GC07P045574
  • GC07P045668
  • GC07P045701
  • GC07P045894
  • GC07P045816
  • GC07P045927

Summaries for IGFBP1 Gene

Entrez Gene Summary for IGFBP1 Gene

  • This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGFBP1 Gene

IGFBP1 (Insulin-Like Growth Factor Binding Protein 1) is a Protein Coding gene. Diseases associated with IGFBP1 include mild pre-eclampsia and uterine disease. Among its related pathways are AhR pathway (WikiPathways) and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is IGFBP4.

UniProtKB/Swiss-Prot for IGFBP1 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Gene Wiki entry for IGFBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP1 Gene

Genomics for IGFBP1 Gene

Regulatory Elements for IGFBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IGFBP1 Gene

Start:
45,888,357 bp from pter
End:
45,893,668 bp from pter
Size:
5,312 bases
Orientation:
Plus strand

Genomic View for IGFBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGFBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP1 Gene

Proteins for IGFBP1 Gene

  • Protein details for IGFBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08833-IBP1_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 1
    Protein Accession:
    P08833
    Secondary Accessions:
    • A4D2F4
    • D3DVL9
    • Q8IYP5

    Protein attributes for IGFBP1 Gene

    Size:
    259 amino acids
    Molecular mass:
    27904 Da
    Quaternary structure:
    • Binds equally well IGF1 and IGF2.
    SequenceCaution:
    • Sequence=AAA52540.1; Type=Frameshift; Positions=55, 71; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGFBP1 Gene

neXtProt entry for IGFBP1 Gene

Proteomics data for IGFBP1 Gene at MOPED

Post-translational modifications for IGFBP1 Gene

  • Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGFBP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for IGFBP1 Gene

Domains for IGFBP1 Gene

Graphical View of Domain Structure for InterPro Entry

P08833

UniProtKB/Swiss-Prot:

IBP1_HUMAN :
  • P08833
Domain:
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with IGFBP1: view

No data available for Gene Families for IGFBP1 Gene

Function for IGFBP1 Gene

Molecular function for IGFBP1 Gene

GENATLAS Biochemistry: insulin-like growth factor binding protein 1,high affinity,expressed in liver, decidua,kidney and in amniotic fluid,regulator of somatic growth and cellular proliferation,regulated by insulin and corticoids,duplicated in an atypical Silver Russel syndrome
UniProtKB/Swiss-Prot Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Gene Ontology (GO) - Molecular Function for IGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005520 insulin-like growth factor binding TAS 2454104
GO:0031994 insulin-like growth factor I binding IBA --
GO:0031995 insulin-like growth factor II binding IBA --
genes like me logo Genes that share ontologies with IGFBP1: view

Phenotypes for IGFBP1 Gene

genes like me logo Genes that share phenotypes with IGFBP1: view

Animal Models for IGFBP1 Gene

MGI Knock Outs for IGFBP1:

Animal Model Products

CRISPR Products

miRNA for IGFBP1 Gene

miRTarBase miRNAs that target IGFBP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IGFBP1 Gene

Localization for IGFBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFBP1 Gene COMPARTMENTS Subcellular localization image for IGFBP1 gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IGFBP1: view

Pathways for IGFBP1 Gene

genes like me logo Genes that share pathways with IGFBP1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0007165 signal transduction TAS 2454104
GO:0008286 insulin receptor signaling pathway IEA --
GO:0030307 positive regulation of cell growth IEA --
genes like me logo Genes that share ontologies with IGFBP1: view

Compounds for IGFBP1 Gene

(103) Novoseek inferred chemical compound relationships for IGFBP1 Gene

Compound -log(P) Hits PubMed IDs
pp-12 83.2 15
c-peptide 70.5 79
glucose 69.3 232
estradiol 63.2 52
progesterone 62.9 86
genes like me logo Genes that share compounds with IGFBP1: view

Transcripts for IGFBP1 Gene

mRNA/cDNA for IGFBP1 Gene

Unigene Clusters for IGFBP1 Gene

Insulin-like growth factor binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFBP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IGFBP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP1 Gene

No ASD Table

Relevant External Links for IGFBP1 Gene

GeneLoc Exon Structure for
IGFBP1
ECgene alternative splicing isoforms for
IGFBP1

Expression for IGFBP1 Gene

mRNA expression in normal human tissues for IGFBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBP1 Gene

This gene is overexpressed in Liver (50.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IGFBP1 Gene

SOURCE GeneReport for Unigene cluster for IGFBP1 Gene Hs.642938

genes like me logo Genes that share expressions with IGFBP1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IGFBP1 Gene

Orthologs for IGFBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBP1 35
  • 99.49 (n)
  • 98.84 (a)
IGFBP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGFBP1 35
  • 76.45 (n)
  • 69.5 (a)
IGFBP1 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGFBP1 35
  • 72.27 (n)
  • 65.98 (a)
IGFBP1 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igfbp1 35
  • 75.71 (n)
  • 71.61 (a)
Igfbp1 16
Igfbp1 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFBP1 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP1 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igfbp1 35
  • 75.25 (n)
  • 73.84 (a)
chicken
(Gallus gallus)
Aves IGFBP1 35
  • 61.86 (n)
  • 55.46 (a)
IGFBP1 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGFBP1 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbp1 35
  • 56.91 (n)
  • 50.66 (a)
zebrafish
(Danio rerio)
Actinopterygii igfbp1a 36
  • 35 (a)
OneToMany
igfbp1b 35
  • 56.44 (n)
  • 45.54 (a)
igfbp1b 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for IGFBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP1 Gene

ENSEMBL:
Gene Tree for IGFBP1 (if available)
TreeFam:
Gene Tree for IGFBP1 (if available)

Paralogs for IGFBP1 Gene

Paralogs for IGFBP1 Gene

Selected SIMAP similar genes for IGFBP1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IGFBP1: view

Variants for IGFBP1 Gene

Sequence variations from dbSNP and Humsavar for IGFBP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4619 - 45,893,070(+) CAGAT(A/G)TATTT reference, missense
rs7454 -- 45,893,407(+) AAGAG(C/G)ATGGA utr-variant-3-prime
rs13619 -- 45,893,252(+) TTATT(A/C)ACTGT utr-variant-3-prime
rs1052652 -- 45,893,195(+) ATATA(C/T)AGTAA utr-variant-3-prime
rs1065780 -- 45,888,078(+) TCTGC(A/G)TTTGA upstream-variant-2KB

Relevant External Links for IGFBP1 Gene

HapMap Linkage Disequilibrium report
IGFBP1
Human Gene Mutation Database (HGMD)
IGFBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGFBP1 Gene

Disorders for IGFBP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (22) Diseases for IGFBP1 Gene including...

Search for IGFBP1 Gene in MalaCards »

(95) Novoseek inferred disease relationships for IGFBP1 Gene

Disease -log(P) Hits PubMed IDs
insulin sensitivity 72.5 61
insulin resistance 70.8 69
polycystic ovary syndrome 66.5 10
growth failure 63.5 6
hyperinsulinemia 62.9 27

Relevant External Links for IGFBP1

Genetic Association Database (GAD)
IGFBP1
Human Genome Epidemiology (HuGE) Navigator
IGFBP1
genes like me logo Genes that share disorders with IGFBP1: view

No data available for UniProtKB/Swiss-Prot for IGFBP1 Gene

Publications for IGFBP1 Gene

  1. Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101. (PMID: 7678248) Jones J.I. … Clemmons D.R. (J. Biol. Chem. 1993) 3 4 23
  2. Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort. (PMID: 17035411) Cheng I. … Freedman M.L. (Cancer Epidemiol. Biomarkers Prev. 2006) 3 23 48
  3. IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3). (PMID: 18596909) Patel A.V. … Feigelson H.S. (PLoS ONE 2008) 3 23 48
  4. Insulin-like growth factor-binding protein-1: serum levels, promoter polymorphism, and associations with components of the metabolic syndrome in short subjects born small for gestational age. (PMID: 19158202) van der Kaay D. … Hokken-Koelega A. (J. Clin. Endocrinol. Metab. 2009) 3 23 48
  5. Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms. (PMID: 19765076) Dolcini L. … Galliano M. (FEBS J. 2009) 3 4 23

Products for IGFBP1 Gene

Sources for IGFBP1 Gene

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