Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGFBP1 Gene

protein-coding GIFtS: 63
GCID: GC07P045927

insulin-like growth factor binding protein 1

(Previous symbol: IBP1)

Explore 141 diseases affiliated with
IGFBP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Insulin-Like Growth Factor Binding Protein 1¹ ²		IGF-Binding Protein 1² ³
IBP1¹ ² ³		Alpha-Pregnancy-Associated Endometrial Globulin²
PP12¹ ² ³		Amniotic Fluid Binding Protein²
AFBP¹ ²		Binding Protein-25²
IGF-BP25¹ ²		Binding Protein-26²
HIGFBP-1¹		Binding Protein-28²
Placental Protein 12² ³		Growth Hormone Independent-Binding Protein²
IBP-1² ³		Insulin-Like Growth Factor-Binding Protein 1²
IGFBP-1² ³

External Ids:	HGNC: 5469¹	Entrez Gene: 3484²	Ensembl: ENSG00000146678⁷	OMIM: 146730⁵	UniProtKB: P08833³

Export aliases for IGFBP1 gene to outside databases

Previous GC identifers: GC07P045574 GC07P045668 GC07P045701 GC07P045894 GC07P045816

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGFBP1:

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an

IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and

circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with

cell surface receptors. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IBP1_HUMAN, P08833

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the

growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface

receptors. Promotes cell migration

Gene Wiki entry for IGFBP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGFBP1 gene promoter:
c-Fos TBP PPAR-alpha p53 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): IGFBP1 promoter sequence

Search SABiosciences Chromatin IP Primers for IGFBP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13-p12 Ensembl cytogenetic band: 7p12.3 HGNC cytogenetic band: 7p13-p12

IGFBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P045927: view genomic region (about GC identifiers)

Start:	45,927,956 bp from pter	End:	45,933,267 bp from pter
Size:	5,312 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 45,967,292-45,972,600

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IBP1_HUMAN, P08833 (See protein sequence)

Recommended Name: Insulin-like growth factor-binding protein 1 precursor

Size: 259 amino acids; 27904 Da

Subunit: Binds equally well IGF1 and IGF2

Subcellular location: Secreted

Sequence caution: Sequence=AAA52540.1; Type=Frameshift; Positions=55, 71;

3 PDB 3D structures from and Proteopedia for IGFBP1:

1ZT3 (3D)

1ZT5 (3D)

2DSQ (3D)

Secondary accessions: A4D2F4 D3DVL9 Q8IYP5

Explore the universe of human proteins at neXtProt for IGFBP1: NX_P08833

Post-translational modifications:

Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic

fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are

present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08833

IGFBP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000587.1

ENSEMBL proteins:

ENSP00000275525 ENSP00000413511 ENSP00000417069

Reactome Protein details: P08833
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IGFBP1 (IGFBP-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: IGFBP1 OriGene Protein Over-expression Lysate: IGFBP1 OriGene Custom Protein Services for IGFBP1
	GenScript Custom Purified and Recombinant Proteins Services for IGFBP1
	Novus Biologicals IGFBP1 Proteins Novus Biologicals IGFBP1 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IGFBP1
	Uscn Proteins for IGFBP1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

IGFBP1 for ontologies About GeneDecksing

IGFBP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IGFBP1
	R&D Systems Antibodies for IGFBP1 (IGFBP-1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for IGFBP1
	GenScript Custom Superior Antibodies Services for IGFBP1
	Novus Biologicals IGFBP1 Antibodies
	Search for Antibodies for IGFBP1 at Abcam
	Uscn Antibodies for IGFBP1
	ThermoFisher Antibodies for IGFBP1

Assay Products for IGFBP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IGFBP1 (IGFBP-1) (see all)
	GenScript Custom Assay Services for IGFBP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IGFBP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGFBP1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000716 Thyroglobulin_1

IPR022321 IGFBP_1-6_chordata

IPR000867 IGFBP-like

IPR009168 IGFBP1-6

IPR017891 Insulin_GF-bd_Cys-rich_CS

Graphical View of Domain Structure for InterPro Entry P08833

ProtoNet protein and cluster: P08833

2 Blocks protein families:

IPB000716 Thyroglobulin type-1

IPB000867 Insulin-like growth factor-binding protein

UniProtKB/Swiss-Prot: IBP1_HUMAN, P08833

Similarity: Contains 1 IGFBP N-terminal domain

Similarity: Contains 1 thyroglobulin type-1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IBP1_HUMAN, P08833

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the

growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface

receptors. Promotes cell migration

Genatlas biochemistry entry for IGFBP1:

insulin-like growth factor binding protein 1,high affinity,expressed in liver, decidua,kidney and in amniotic

fluid,regulator of somatic growth and cellular proliferation,regulated by insulin and corticoids,duplicated in an

atypical Silver Russel syndrome

miRNA Products:		OriGene 3'-UTR Clone: IGFBP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBP1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP1:
		hsa-miR-433 hsa-miR-3163 hsa-miR-892a
		SwitchGear 3'UTR luciferase reporter plasmid: IGFBP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFBP1 (see all 7) OriGene shRNA RFP: IGFBP1 OriGene siRNA: IGFBP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IGFBP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IGFBP1 (NM_000596)
		Sino Biological Human cDNA Clone for IGFBP1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGFBP1
		Search LifeMap BioReagents cell lines for IGFBP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005520	insulin-like growth factor binding	IEA	--

IGFBP1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Igfbp1^tm1Taub for IGFBP1
     3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Igfbp1):

cellular

immune system

liver/biliary system

IGFBP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development IGF-RI signaling

Development IGF-RI signaling

1.00

Development_IGF-1 receptor signaling

0.99

Activation of Genes by ATF4

Activation of Genes by ATF4

1.00

PERK regulated gene expression

0.64

Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

1.00

Expression of IGFBP1

Expression of IGFBP1

1.00

Selected targets of GCR-alpha

Selected targets of GCR-alpha

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for IGFBP1

	Selected targets of GCR-alpha
	Selected targets of HNF1
	Development IGF-RI signaling

1 GeneGo (Thomson Reuters) Pathway for IGFBP1

Development IGF-1 receptor signaling

3 BioSystems Pathways for IGFBP1

	Myometrial Relaxation and Contraction Pathways
	HIF-1-alpha transcription factor network
	FOXA2 and FOXA3 transcription factor networks

5/6 Reactome Pathways for IGFBP1 (see all 6)

	Expression of IGFBP1
	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	PERK regulated gene expression
	Metabolism of proteins
	Activation of Genes by ATF4

IGFBP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IGFBP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/12 Interacting proteins for IGFBP1 (P08833³ ENSP00000275525⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGF1	P05019³, ENSP00000302665⁴	I2D: score=2 STRING: ENSP00000302665
IGF2	P01344³, ENSP00000338297⁴	I2D: score=2 STRING: ENSP00000338297
MMP26	Q9NRE1³, ENSP00000300762⁴	I2D: score=1 STRING: ENSP00000300762
TF	P02787³, ENSP00000264998⁴	I2D: score=1 STRING: ENSP00000264998
ARNT	ENSP00000351407⁴	STRING: ENSP00000351407

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	--	--
GO:0006987	activation of signaling protein activity involved in unfolded protein response	TAS	--
GO:0007165	signal transduction	TAS	2454104
GO:0008286	insulin receptor signaling pathway	IEA	--
GO:0030307	positive regulation of cell growth	IEA	--

IGFBP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IGFBP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGFBP1
10/103 Novoseek chemical compound relationships for IGFBP1 gene (see all 103) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pp-12	83.2	17	2318953 (7), 7530848 (2), 1534990 (2), 1840727 (1) (see all 7)
c-peptide	70.5	86	17285578 (4), 11524238 (4), 11808715 (4), 19064975 (3) (see all 47)
glucose	69.3	476	9170816 (7), 7693379 (6), 9284705 (5), 7687525 (5) (see all 99)
estradiol	63.2	69	17484513 (3), 15713723 (2), 16891052 (2), 11075292 (2) (see all 43)
progesterone	62.9	117	12843192 (9), 8915665 (4), 15501902 (3), 17585572 (3) (see all 57)
dehydroepiandrosterone sulfate	58.7	24	10561001 (3), 9595787 (2), 7561622 (2), 10407219 (1) (see all 15)
testosterone	58.2	120	10762293 (7), 15713723 (3), 7534218 (3), 15963068 (3) (see all 61)
androstenedione	56.4	23	7534218 (2), 7516827 (2), 9359637 (2), 14557441 (1) (see all 16)
octreotide	48.1	70	1281485 (7), 1713220 (6), 1385103 (6), 8543925 (5) (see all 18)
pegvisomant	47	4	19075184 (1), 14700556 (1)

Search CenterWatch for drugs/clinical trials and news about IGFBP1 / IBP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IGFBP1 gene (2 alternative transcripts):

NM_000596.2 NM_001013029.1

Unigene Cluster for IGFBP1:

Insulin-like growth factor binding protein 1

Hs.642938 [show with all ESTs]

Unigene Representative Sequence: NM_000596

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000275525(uc003tnp.3) ENST00000457280 ENST00000468955

miRNA Products:		OriGene 3'-UTR Clone: IGFBP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFBP1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate IGFBP1:
		hsa-miR-433 hsa-miR-3163 hsa-miR-892a
		SwitchGear 3'UTR luciferase reporter plasmid: IGFBP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFBP1 (see all 7) OriGene shRNA RFP: IGFBP1 OriGene siRNA: IGFBP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IGFBP1 (NM_000596)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFBP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGFBP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IGFBP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP1

Additional cDNA sequence:

AF042356.1 AK314925.1 BC035263.1 BC057806.1 BT019685.1 FJ795026.1 M20841.1 M31145.1

X12385.1 X13405.1 X15002.1 Y00856.1

24/27 DOTS entries (see all 27):

DT.100891915 DT.219024 DT.95263421 DT.100762376 DT.100891936 DT.100891833 DT.100891882 DT.100761213

DT.95367679 DT.91724975 DT.100891850 DT.100891932 DT.104575 DT.449084 DT.100891924 DT.91673738

DT.92453318 DT.100699965 DT.100891871 DT.100891905 DT.100891916 DT.100891922 DT.100891949 DT.100891967

24/981 AceView cDNA sequences (see all 981):

BF111595 BX335485 CR620278 CR622062 AA151533 BX381974 CR591333 CR600995

BX334412 CR602277 CR598858 CR602661 CR617913 CR590828 BX357310 BX381988

CR600132 NM_000596 CR620546 BX361542 X12385 CR614706 CR610941 CR618725

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGFBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAAATACT

About this image

IGFBP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Skeletal Muscle

Mandibular Arch Muscles

Skeletal Muscle

Kidney

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See IGFBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGFBP1

SOURCE GeneReport for Unigene cluster: Hs.642938

SABiosciences Expression via Pathway-Focused PCR Arrays including IGFBP1:

Nephrotoxicity in human mouse rat

Insulin Signaling Pathway in human mouse rat

Polycomb & Trithorax Target Genes in human mouse rat

Liver Cancer in human mouse rat

Fatty Liver in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGFBP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IGFBP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP1 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IGFBP1¹	insulin-like growth factor binding protein 1	61.56(n) 54.84(a)		408027 NM_001001294.1 NP_001001294.1
lizard (Anolis carolinensis)	Reptilia	IGFBP1⁶	--	43(a)	1 ↔ 1	6(53856942-53866331)
zebrafish (Danio rerio)	Actinopterygii	igfbp1a¹	insulin-like growth factor binding protein 1a	55.05(n) 45.7(a)		317638 NM_173283.3 NP_775390.2

ENSEMBL Gene Tree for IGFBP1 (if available)
TreeFam Gene Tree for IGFBP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGFBP1 gene

IGFBP5² IGFBP2² IGFBP6² IGFBP4² IGFBP3²

2 SIMAP similar genes for IGFBP1 using alignment to 5 protein entries: IBP1_HUMAN (see all proteins):

IGFBP4 IGFBP2

IGFBP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76240462^1,2		--	45926121(+)	`TCTTTA/GGATTG`	1	--	us2k¹		2		CSA WA	120
rs116616276^1,2	F,	--	45926179(+)	`GAAAGG/TGTATG`	1	--	us2k¹		1		WA	118
rs141512952^1,2		--	45926707(+)	`CACCTG/TCCCTG`	1	--	us2k¹		0	--	--	--	--
rs187423208^1,2		--	45926762(+)	`CACTTA/GAGGTG`	1	--	us2k¹		0	--	--	--	--
rs118153012^1,2		--	45926852(+)	`AACAGG/AACTGT`	1	--	us2k¹		1		NA	120
rs9658184^1,2	C,F,H,	--	45926897(+)	`ccaccG/Attata`	1	--	us2k¹ tfbs³		7		NS NA CSA	744
rs112852684^1,2	F	--	45926966(+)	`ATAAAG/TCAAGG`	1	--	us2k¹		2		CSA	4
rs139395834^1,2		--	45927046(+)	`GAGGCC/TCAGGC`	1	--	us2k¹		0	--	--	--	--
rs78116718^1,2		--	45927092(+)	`TGGGAC/GGCAAA`	1	--	us2k¹		0	--	--	--	--
rs112466103^1,2		--	45927097(+)	`GGCAAA/GGATGG`	1	--	us2k¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for IGFBP1 (45927956 - 45933267 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IGFBP1: --
Human Gene Mutation Database (HGMD): IGFBP1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFBP1

DNA2.0 Custom Variant and Variant Library Synthesis for IGFBP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGFBP1 for disorders           About GeneDecksing

OMIM gene information: 146730    OMIM disorders: --

20/141 diseases for IGFBP1 (see all 141):    About MalaCards

protein-energy malnutrition acid-labile subunit mild pre-eclampsia pre-eclampsia

severe pre-eclampsia persistent fetal circulation syndrome alveolar soft part sarcoma silver-russell syndrome

growth hormone deficiency ehlers-danlos syndrome proliferative diabetic retinopathy focal segmental glomerulosclerosis

placental insufficiency glucose intolerance prader-willi syndrome metabolic syndrome x

polycystic ovary syndrome short stature diabetic retinopathy chronic fatigue syndrome

6 diseases from the University of Copenhagen DISEASES database for IGFBP1:

Polycystic ovary syndrome Diabetes mellitus Hyperinsulinism Hyperandrogenism

Hyperglycemia Infertility

10/95 Novoseek disease relationships for IGFBP1 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin sensitivity	72.5	72	7593430 (5), 10396366 (3), 15598684 (3), 9032568 (2) (see all 47)
insulin resistance	70.8	84	1375600 (3), 14687242 (2), 11028691 (2), 7693379 (2) (see all 58)
polycystic ovary syndrome	66.5	16	1283982 (2), 7516827 (2), 8671313 (1), 11569168 (1) (see all 8)
growth failure	63.5	7	1280613 (2), 8792402 (1), 9048593 (1), 9402139 (1) (see all 5)
hyperinsulinemia	62.9	33	8954066 (2), 10868969 (1), 19158202 (1), 7507119 (1) (see all 26)
hyperandrogenism	62.1	8	7589662 (1), 12477526 (1), 15063962 (1), 17709876 (1) (see all 7)
growth retardation	59.7	17	12489207 (3), 16809446 (2), 7531120 (1), 8636264 (1) (see all 12)
intrauterine growth retardation	56.7	24	16809446 (2), 7532055 (2), 8989275 (1), 12489207 (1) (see all 15)
fetal hypoxia	56.3	5	8821897 (1), 10946870 (1), 9707622 (1), 7532055 (1)
diabetes mellitus insulin-dependent	53.6	27	12153746 (2), 7530621 (2), 7534144 (2), 11392040 (1) (see all 18)

Human Genome Epidemiology (HuGE) Navigator: IGFBP1 (53 documents)

Export disorders for IGFBP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGFBP1 gene, integrated from 9 sources (see all 1244):
(articles sorted by number of sources associating them with IGFBP1)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1). (PubMed id 2461294)^{1, 2, 3} Brinkman A.... Drop S.L.S. (1988)
The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry. (PubMed id 10329650)^{1, 2, 9} Neumann G.M. and Bach L.A. (1999)
Identification of the amniotic fluid insulin-like gro wth factor binding protein-1 phosphorylation sites and propensity to proteolysi s of the isoforms. (PubMed id 19765076)^{1, 2, 9} Dolcini L....Galliano M. (2009)
Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. (PubMed id 16924115)^{1, 2, 9} Sitar T.... Holak T.A. (2006)
Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101. (PubMed id 7678248)^{1, 2, 9} Jones J.I....Clemmons D.R. (1993)
Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid. (PubMed id 15972819)^{1, 2} Sala A.... Monaco H.L. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7. (PubMed id 1373120)^{1, 2} Ehrenborg E....Luthman H. (1992)
Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability. (PubMed id 1718783)^{1, 2} Brinkman A....Drop S.L.S. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3484	HGNC: 5469	AceView: IGFBP1	Ensembl:ENSG00000146678	euGenes: HUgn3484
ECgene: IGFBP1	H-InvDB: IGFBP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IGFBP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IGFBP1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/igfbp1/

Intellectual Property for IGFBP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IGFBP1 gene:
Search GeneIP for patents involving IGFBP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of IGFBP1
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for IGFBP1 (IGFBP-1)		Browse Cell Culture Products
	ELISAs for IGFBP1 (IGFBP-1)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for IGFBP1 (IGFBP-1)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for IGFBP1 (IGFBP-1)

	Browse OriGene Antibodies		OriGene shRNA RFP for IGFBP1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFBP1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGFBP1
	OriGene Protein Over-expression Lysate for IGFBP1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for IGFBP1		OriGene 3'-UTR Clone for IGFBP1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFBP1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for IGFBP1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for IGFBP1		OriGene Custom Protein Services for IGFBP1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGFBP1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFBP1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFBP1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFBP1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFBP1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFBP1

	GenScript Custom Purified and Recombinant Proteins Services for IGFBP1		GenScript cDNA clones with any tag delivered in your preferred vector for IGFBP1
	GenScript Custom Assay Services for IGFBP1		GenScript Custom Superior Antibodies Services for IGFBP1
	GenScript Custom overexpressing Cell Line Services for IGFBP1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in IGFBP1 promoter
	Search Chromatin IP Primers for IGFBP1
	RT² qPCR Primer Assay in human, mouse, rat IGFBP1
	GNC Network for IGFBP1
	SABiosciences PCR Arrays including human, mouse, rat IGFBP1

Search Tocris compounds for IGFBP1

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for IGFBP1
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	IGFBP1 antibodies
	IGFBP1 proteins
	IGFBP1 lysates

	Search for Antibodies for IGFBP1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for IGFBP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for IGFBP1

IGFBP1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for IGFBP1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP1

	SwitchGear 3'UTR luciferase reporter plasmids for IGFBP1
	SwitchGear Promoter luciferase reporter plasmids for IGFBP1

ThermoFisher Antibodies for IGFBP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFBP1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IGFBP1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

IGFBP1 Gene

insulin-like growth factor binding protein 1

Aliases
for IGFBP1 gene

Summaries
for IGFBP1 gene

Genomic Views
for IGFBP1 gene

Proteins
for IGFBP1 gene

Protein Domains /
Families
for IGFBP1 gene

Function
for IGFBP1 gene

Pathways & Interactions
for IGFBP1 gene

Drugs & Compounds
for IGFBP1 gene

Transcripts
for IGFBP1 gene

Expression
for IGFBP1 gene

Orthologs
for IGFBP1 gene

Paralogs
for IGFBP1 gene

Genomic Variants
for IGFBP1 gene

Disorders / Diseases
for IGFBP1 gene

Publications
for IGFBP1 gene

External Searches for IGFBP1 gene

Genome Databases showing IGFBP1 gene

Other Databases showing IGFBP1 gene

Specialized Databases showing IGFBP1 gene

Intellectual Property
for IGFBP1 gene

Products
for IGFBP1 gene

View Random Gene

preterm delivery
Protein-Energy Malnutrition
Infertility
Mild pre-eclampsia
Hyperinsulinemia
hypercortisolemia
Endometriosis
Acute myocardial infarction
LARON SYNDROME
Glucose Intolerance
insulin sensitivity
Pregnancy Tubal
Turners Syndrome
Breast Cancer
Hypoglycemia
AIDS
Adenocarcinoma
Placental Insufficiency
disability
Diabetes Mellitus Insulin-Dependent
Eye Diseases
bone loss
Malnutrition
Uterine leiomyoma
SHORT STATURE
Cysts
immunodeficiency
Hepatitis
Hyperglycemia
Hypertrophy
Cervical Cancer
ENDOMETRIAL CARCINOMA
Severe pre-eclampsia
prostate cancer
Cardiovascular Diseases
Tumors
Metastasis
metabolic disorder
Lymphoblastic Leukemia Acute
Preeclampsia
Hyperinsulinism
ENDOCRINE DISORDER
Hyperandrogenism
Anovulation
Cushing Syndrome
insulin tolerance
Critically Ill
Anorexia Nervosa
atherosclerotic plaque
Carcinoma
retinopathy
Diabetes Gestational
Fetal hypoxia
Leukemia
Acromegaly
Diabetes Mellitus
Osteosarcoma
High-Risk Pregnancy
Growth failure
Diabetic Retinopathy
MENSTRUAL IRREGULARITY
Endocrine Effects
Biliary Atresia
Intrauterine Growth Retardation
Metabolic Syndrome X
Cancer Lung
Uremia
Myocardial Infarction
Chronic Fatigue Syndrome
Ovarian dysfunction
Coronary Artery Disease
Proliferative diabetic retinopathy
Insulin Resistance
growth hormone deficiency
Ascites
impaired glucose tolerance
Adenoma
benign prostatic hyperplasia
Bleeding
OBESITY
Polycystic Ovary Syndrome
Carcinoma Squamous Cell
HYPERPARATHYROIDISM PRIMARY
associated conditions
STROKE
Ovarian Diseases
Chromosomal Aberrations
Oligomenorrhea
Renal Osteodystrophy
Cholera
NIDDM
Growth retardation
Polycystic ovaries
Endometrial Cancer
Renal Failure Chronic

Advanced Search

Export list of displayed genes

IGFBP1 Gene

insulin-like growth factor binding protein 1

Aliasesfor IGFBP1 gene

Summariesfor IGFBP1 gene

Genomic Viewsfor IGFBP1 gene

Proteinsfor IGFBP1 gene

Protein Domains /Familiesfor IGFBP1 gene

Functionfor IGFBP1 gene

Pathways & Interactionsfor IGFBP1 gene

Drugs & Compoundsfor IGFBP1 gene

Transcriptsfor IGFBP1 gene

Expression for IGFBP1 gene

Orthologsfor IGFBP1 gene

Paralogsfor IGFBP1 gene

Genomic Variantsfor IGFBP1 gene

Disorders / Diseasesfor IGFBP1 gene

Publicationsfor IGFBP1 gene

External Searches for IGFBP1 gene

Genome Databases showing IGFBP1 gene

Other Databases showing IGFBP1 gene

Specialized Databases showing IGFBP1 gene

Intellectual Propertyfor IGFBP1 gene

Productsfor IGFBP1 gene

View Random Gene

Aliases
for IGFBP1 gene

Summaries
for IGFBP1 gene

Genomic Views
for IGFBP1 gene

Proteins
for IGFBP1 gene

Protein Domains /
Families
for IGFBP1 gene

Function
for IGFBP1 gene

Pathways & Interactions
for IGFBP1 gene

Drugs & Compounds
for IGFBP1 gene

Transcripts
for IGFBP1 gene

Expression
for IGFBP1 gene

Orthologs
for IGFBP1 gene

Paralogs
for IGFBP1 gene

Genomic Variants
for IGFBP1 gene

Disorders / Diseases
for IGFBP1 gene

Publications
for IGFBP1 gene

Intellectual Property
for IGFBP1 gene

Products
for IGFBP1 gene