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IGFBP1 Gene

protein-coding   GIFtS: 64
GCID: GC07P045927

Insulin-Like Growth Factor Binding Protein 1


(Previous symbol: IBP1)
  See IGFBP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin-Like Growth Factor Binding Protein 11 2     Growth Hormone Independent-Binding Protein1 2
IBP11 2 3     IBP-12 3
IGF-Binding Protein 11 2 3     IGFBP-12 3
Placental Protein 121 2 3     PP122 3
Alpha-Pregnancy-Associated Endometrial Globulin1 2     AFBP2
Amniotic Fluid Binding Protein1 2     IGF-BP252
Binding Protein-251 2     hIGFBP-12
Binding Protein-261 2     Insulin-Like Growth Factor-Binding Protein 12
Binding Protein-281 2     

External Ids:    HGNC: 54691   Entrez Gene: 34842   Ensembl: ENSG000001466787   OMIM: 1467305   UniProtKB: P088333   

Export aliases for IGFBP1 gene to outside databases

Previous GC identifers: GC07P045574 GC07P045668 GC07P045701 GC07P045894 GC07P045816


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGFBP1 Gene:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with
an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I
and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their
interaction with cell surface receptors. (provided by RefSeq, Jul 2008)

GeneCards Summary for IGFBP1 Gene:
IGFBP1 (insulin-like growth factor binding protein 1) is a protein-coding gene. Diseases associated with IGFBP1 include uterine disease, and mild pre-eclampsia. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot: IBP1_HUMAN, P08833
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
cell surface receptors. Promotes cell migration

Gene Wiki entry for IGFBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGFBP1 gene promoter:
         c-Fos   TBP   PPAR-alpha   p53   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): IGFBP1 promoter sequence
   Search Chromatin IP Primers for IGFBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13-p12   Ensembl cytogenetic band:  7p12.3   HGNC cytogenetic band: 7p13-p12

IGFBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P045927:  view genomic region     (about GC identifiers)

Start:
45,927,956 bp from pter      End:
45,933,267 bp from pter
Size:
5,312 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 45,967,292-45,972,600     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IBP1_HUMAN, P08833 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein 1 precursor  
Size: 259 amino acids; 27904 Da
Subunit: Binds equally well IGF1 and IGF2
Sequence caution: Sequence=AAA52540.1; Type=Frameshift; Positions=55, 71;
3 PDB 3D structures from and Proteopedia for IGFBP1:
1ZT3 (3D)        1ZT5 (3D)        2DSQ (3D)    
Secondary accessions: A4D2F4 D3DVL9 Q8IYP5

Explore the universe of human proteins at neXtProt for IGFBP1: NX_P08833

Explore proteomics data for IGFBP1 at MOPED

Post-translational modifications: 

  • Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In
    amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated
    forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IGFBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000587.1  
    ENSEMBL proteins: 
     ENSP00000275525   ENSP00000413511   ENSP00000417069  
    Reactome Protein details: P08833

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    Cloud-Clone Corp. ELISAs for IGFBP1
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    Search eBioscience for ELISAs for IGFBP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR000716 Thyroglobulin_1
     IPR022321 IGFBP_1-6_chordata
     IPR000867 IGFBP-like
     IPR009168 IGFBP1-6
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry P08833

    ProtoNet protein and cluster: P08833

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB000867 Insulin-like growth factor-binding protein


    UniProtKB/Swiss-Prot: IBP1_HUMAN, P08833
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    Find genes that share domains with IGFBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IBP1_HUMAN, P08833
    Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or
    stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their
    cell surface receptors. Promotes cell migration

         Genatlas biochemistry entry for IGFBP1:
    insulin-like growth factor binding protein 1,high affinity,expressed in liver, decidua,kidney and in amniotic
    fluid,regulator of somatic growth and cellular proliferation,regulated by insulin and corticoids,duplicated in an
    atypical Silver Russel syndrome

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005520insulin-like growth factor binding IEA--
         
    Find genes that share ontologies with IGFBP1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Igfbp1):
     cellular  immune system  liver/biliary system 

    Find genes that share phenotypes with IGFBP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Igfbp1tm1Taub for IGFBP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGFBP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGFBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGFBP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGFBP1

    miRNA
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    miRTarBase miRNAs that target IGFBP1:
    hsa-mir-29c-3p (MIRT006386), hsa-mir-124-3p (MIRT022268)

    Block miRNA regulation of human, mouse, rat IGFBP1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate IGFBP1:
    hsa-miR-433 hsa-miR-3163 hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidIGFBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IGFBP1
    Predesigned siRNA for gene silencing in human, mouse, rat IGFBP1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: IGFBP1 (NM_000596)
    Sino Biological Human cDNA Clone for IGFBP1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IBP1_HUMAN, P08833: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IGFBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGFBP1 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    2PERK regulated gene expression
    PERK regulated gene expression0.90
    Activation of Genes by ATF40.90
    3Unfolded Protein Response
    Unfolded Protein Response0.61
    4Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with IGFBP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for IGFBP1
        Development IGF-1 receptor signaling

    4 BioSystems Pathways for IGFBP1
        Myometrial Relaxation and Contraction Pathways
    AhR pathway
    HIF-1-alpha transcription factor network
    FOXA2 and FOXA3 transcription factor networks


    2 Reactome Pathways for IGFBP1
        Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    ATF4 activates genes


        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGFBP1: 
              Nephrotoxicity in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Liver Cancer in human mouse rat
              Fatty Liver in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IGFBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for IGFBP1 (P088333 ENSP000002755254) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGF1P050193, ENSP000003026654I2D: score=2 STRING: ENSP00000302665
    MMP26Q9NRE13, ENSP000003007624I2D: score=1 STRING: ENSP00000300762
    TFP027873, ENSP000002649984I2D: score=1 STRING: ENSP00000264998
    IGF2P013443I2D: score=2 
    ARNTENSP000003514074STRING: ENSP00000351407
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth ----
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0007165signal transduction TAS2454104
    GO:0008286insulin receptor signaling pathway IEA--
    GO:0030307positive regulation of cell growth IEA--

    Find genes that share ontologies with IGFBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGFBP1 (IBP1)

    Selected Novoseek inferred chemical compound relationships for IGFBP1 gene (see all 103)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pp-12 83.2 17 2318953 (7), 7530848 (2), 1534990 (2), 1840727 (1) (see all 7)
    c-peptide 70.5 86 17285578 (4), 11524238 (4), 11808715 (4), 19064975 (3) (see all 47)
    glucose 69.3 476 9170816 (7), 7693379 (6), 9284705 (5), 7687525 (5) (see all 99)
    estradiol 63.2 69 17484513 (3), 15713723 (2), 16891052 (2), 11075292 (2) (see all 43)
    progesterone 62.9 117 12843192 (9), 8915665 (4), 15501902 (3), 17585572 (3) (see all 57)
    dehydroepiandrosterone sulfate 58.7 24 10561001 (3), 9595787 (2), 7561622 (2), 10407219 (1) (see all 15)
    testosterone 58.2 120 10762293 (7), 15713723 (3), 7534218 (3), 15963068 (3) (see all 61)
    androstenedione 56.4 23 7534218 (2), 7516827 (2), 9359637 (2), 14557441 (1) (see all 16)
    octreotide 48.1 70 1281485 (7), 1713220 (6), 1385103 (6), 8543925 (5) (see all 18)
    pegvisomant 47 4 19075184 (1), 14700556 (1)



    Find genes that share compounds with IGFBP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IGFBP1 gene (2 alternative transcripts): 
    NM_000596.2  NM_001013029.1  

    Unigene Cluster for IGFBP1:

    Insulin-like growth factor binding protein 1
    Hs.642938  [show with all ESTs]
    Unigene Representative Sequence: NM_000596
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275525(uc003tnp.3) ENST00000457280 ENST00000468955
    miRNA
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    hsa-miR-433 hsa-miR-3163 hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidIGFBP1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat IGFBP1

    Additional mRNA sequence: 

    AF042356.1 AK314925.1 BC035263.1 BC057806.1 BT019685.1 FJ795026.1 M20841.1 M31145.1 
    X12385.1 X13405.1 X15002.1 Y00856.1 

    Selected DOTS entries (see all 27):

    DT.100891915  DT.219024  DT.95263421  DT.100762376  DT.100891936  DT.100891833  DT.100891882  DT.100761213 
    DT.95367679  DT.91724975  DT.100891850  DT.100891932  DT.104575  DT.449084  DT.91673738  DT.92453318 
    DT.100699965  DT.100891871  DT.100891905  DT.100891916  DT.100891922  DT.100891924  DT.100891949  DT.100891967 

    Selected AceView cDNA sequences (see all 981):

    BX398743 CR620526 CR611770 CR625929 BC057806 CR619099 CR600719 BX361157 
    BX439381 CR621967 AI095925 CR597884 BU752533 CR610351 CR599914 BF111595 
    CR597836 BX382012 BX396234 BX335110 CR619548 CR616351 CR595308 CR616234 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGFBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAATACT
    IGFBP1 Expression
    About this image


    IGFBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Mesothelial Cells Hepatic Mesenchyme
             Liver Lobule
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Epidermis (Integumentary System)
             MSC-containing human skin substitute (Grafix)
     
     Kidney (Urinary System)
             Ureteric Bud
    IGFBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGFBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.642938
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IGFBP1: 
              Nephrotoxicity in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Liver Cancer in human mouse rat
              Fatty Liver in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat IGFBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for IGFBP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igfbp11 , 5 insulin-like growth factor binding protein 11, 5 75.71(n)1
    71.61(a)1
      11 (4.75 cM)5
    160061  NM_008341.41  NP_032367.31 
     71977825 
    chicken
    (Gallus gallus)
    Aves IGFBP11 insulin-like growth factor binding protein 1 61.86(n)
    55.46(a)
      408027  NM_001001294.1  NP_001001294.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGFBP16
    insulin-like growth factor binding protein 1
    46(a)
    1 ↔ 1
    6(53856876-53867301)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia igfbp11 insulin-like growth factor binding protein 1 56.91(n)
    50.66(a)
      619366  NM_001033946.1  NP_001029118.1 
    zebrafish
    (Danio rerio)
    Actinopterygii igfbp1b1 insulin-like growth factor binding protein 1b 56.44(n)
    45.54(a)
      793907  NM_001098257.1  NP_001091727.1 


    ENSEMBL Gene Tree for IGFBP1 (if available)
    TreeFam Gene Tree for IGFBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGFBP1 gene
    IGFBP52  IGFBP22  IGFBP62  IGFBP32  IGFBP42  
    2 SIMAP similar genes for IGFBP1 using alignment to 5 protein entries:     IBP1_HUMAN (see all proteins):
    IGFBP4    IGFBP2

    Find genes that share paralogs with IGFBP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGFBP1 (see all 204)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs762404621,2
    C,F--45926121(+) TCTTTA/GGATTG 1 -- us2k12Minor allele frequency- G:0.10CSA WA 120
    rs1166162761,2
    F--45926179(+) GAAAGG/TGTATG 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1415129521,2
    --45926707(+) CACCTG/TCCCTG 1 -- us2k10--------
    rs1874232081,2
    --45926762(+) CACTTA/GAGGTG 1 -- us2k10--------
    rs1181530121,2
    C,F--45926852(+) AACAGG/AACTGT 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs96581841,2
    C,F,H--45926897(+) ccaccG/Attata 1 -- us2k1 tfbs37Minor allele frequency- A:0.02NS NA CSA 744
    rs1128526841,2
    F--45926966(+) ATAAAG/TCAAGG 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1393958341,2
    --45927046(+) GAGGCC/TCAGGC 1 -- us2k10--------
    rs781167181,2
    --45927092(+) TGGGAC/GGCAAA 1 -- us2k10--------
    rs1124661031,2
    C,F--45927097(+) GGCAAA/GGATGG 1 -- us2k12Minor allele frequency- G:0.11CSA WA 120

    HapMap Linkage Disequilibrium report for IGFBP1 (45927956 - 45933267 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IGFBP1: --
    Human Gene Mutation Database (HGMD): IGFBP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IGFBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for IGFBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146730    OMIM disorders: --

    18 diseases for IGFBP1:    
    About MalaCards
    uterine disease    mild pre-eclampsia    severe pre-eclampsia    eclampsia
    placental insufficiency    ovarian disease    clear cell adenocarcinoma    ovarian clear cell adenocarcinoma
    metabolic syndrome x    diabetic retinopathy    pre-eclampsia    laron syndrome
    chronic fatigue syndrome    silver-russell syndrome    polycystic ovary syndrome    insulin resistance
    myocardial infarction    obesity

    5 diseases from the University of Copenhagen DISEASES database for IGFBP1:
    Diabetes mellitus     Polycystic ovary syndrome     Hyperinsulinism     Hyperandrogenism
    Hyperglycemia

    Find genes that share disorders with IGFBP1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IGFBP1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin sensitivity 72.5 72 7593430 (5), 10396366 (3), 15598684 (3), 9032568 (2) (see all 47)
    insulin resistance 70.8 84 1375600 (3), 14687242 (2), 11028691 (2), 7693379 (2) (see all 58)
    polycystic ovary syndrome 66.5 16 1283982 (2), 7516827 (2), 8671313 (1), 11569168 (1) (see all 8)
    growth failure 63.5 7 1280613 (2), 8792402 (1), 9048593 (1), 9402139 (1) (see all 5)
    hyperinsulinemia 62.9 33 8954066 (2), 10868969 (1), 19158202 (1), 7507119 (1) (see all 26)
    hyperandrogenism 62.1 8 7589662 (1), 12477526 (1), 15063962 (1), 17709876 (1) (see all 7)
    growth retardation 59.7 17 12489207 (3), 16809446 (2), 7531120 (1), 8636264 (1) (see all 12)
    intrauterine growth retardation 56.7 24 16809446 (2), 7532055 (2), 8989275 (1), 12489207 (1) (see all 15)
    fetal hypoxia 56.3 5 8821897 (1), 10946870 (1), 9707622 (1), 7532055 (1)
    diabetes mellitus insulin-dependent 53.6 27 12153746 (2), 7530621 (2), 7534144 (2), 11392040 (1) (see all 18)

    Genetic Association Database (GAD): IGFBP1
    Human Genome Epidemiology (HuGE) Navigator: IGFBP1 (53 documents)

    Export disorders for IGFBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGFBP1 gene, integrated from 10 sources (see all 1258):
    (articles sorted by number of sources associating them with IGFBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1). (PubMed id 2461294)1, 2, 3 Brinkman A.... Drop S.L.S. (EMBO J. 1988)
    2. Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort. (PubMed id 17035411)1, 4, 9 Cheng I....Freedman M.L. (amp 2006)
    3. IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 18596909)1, 4, 9 Patel A.V....Feigelson H.S. (PLoS ONE 2008)
    4. The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry. (PubMed id 10329650)1, 2, 9 Neumann G.M. and Bach L.A. (J. Biol. Chem. 1999)
    5. Insulin-like growth factor-binding protein-1: serum levels, promoter polymorphism, and associations with components of the metabolic syndrome in short subjects born small for gestational age. (PubMed id 19158202)1, 4, 9 van der Kaay D....Hokken-Koelega A. (J. Clin. Endocrinol. Metab. 2009)
    6. Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population. (PubMed id 17566087)1, 4, 9 Cheng I....Le Marchand L. (J. Clin. Endocrinol. Metab. 2007)
    7. Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms. (PubMed id 19765076)1, 2, 9 Dolcini L.... Galliano M. (FEBS J. 2009)
    8. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers. (PubMed id 19843326)1, 4, 9 Neuhausen S.L....Gillen D.L. (Breast Cancer Res. 2009)
    9. Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. (PubMed id 16924115)1, 2, 9 Sitar T.... Holak T.A. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    10. Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study. (PubMed id 16404426)1, 4, 9 Canzian F....Kaaks R. (Br. J. Cancer 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3484 HGNC: 5469 AceView: IGFBP1 Ensembl:ENSG00000146678 euGenes: HUgn3484
    ECgene: IGFBP1 H-InvDB: IGFBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGFBP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGFBP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/igfbp1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGFBP1 gene:
    Search GeneIP for patents involving IGFBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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