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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGFALS Gene

protein-coding   GIFtS: 59
GCID: GC16M001840

insulin-like growth factor binding protein, acid labile...
 Explore 11 diseases affiliated with
IGFALS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGFALS    

Aliases
for IGFALS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit1 2
ALS1 2 3 5
Insulin-Like Growth Factor Binding Protein Complex Acid Labile Chain2
Insulin-Like Growth Factor-Binding Protein Complex Acid Labile Subunit2

External Ids:    HGNC: 54681   Entrez Gene: 34832   Ensembl: ENSG000000997697   OMIM: 6014895   UniProtKB: P358583   
ORGUL members:         
NONCODE:n407836    

Export aliases for IGFALS gene to outside databases

Previous GC identifers: GC16M001857 GC16M001780


Summaries
for IGFALS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IGFALS:
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life
and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is
stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests
itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for
this gene. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: ALS_HUMAN, P35858
Function: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell
adhesion

Gene Wiki entry for IGFALS


Genomic Views
for IGFALS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGFALS gene promoter:
         STAT5B   STAT1   Pax-5   STAT1beta   STAT1alpha   YY1   CP2   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGFALS promoter sequence
   Search SABiosciences Chromatin IP Primers for IGFALS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGFALS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

IGFALS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFALS gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001840:  view genomic region     (about GC identifiers)

Start:
 1,840,414 bp from pter      End:
 1,844,972 bp from pter
Size:
 4,559 bases      Orientation:
 minus strand

Proteins
for IGFALS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ALS_HUMAN, P35858 (See protein sequence)
Recommended Name: Insulin-like growth factor-binding protein complex acid labile subunit precursor  
Size: 605 amino acids; 66035 Da
Subunit: Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3
Subcellular location: Secreted, extracellular space
Secondary accessions: B4DZY8 E9PGU3
Alternative splicing: 2 isoforms:  P35858-1   P35858-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IGFALS: NX_P35858

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35858

    • IGFALS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139478.1  NP_004961.1  

    ENSEMBL proteins: 
     ENSP00000215539   ENSP00000416683   ENSP00000456923  
    Reactome Protein details: P35858
    Human Recombinant Protein Products: 
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    Novus Biologicals IGFALS Protein
    Novus Biologicals IGFALS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IGFALS

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005625soluble fraction ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--


    IGFALS for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for IGFALS

    Protein Domains /
    Families
    for IGFALS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGFALS for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry P35858

    ProtoNet protein and cluster: P35858

    3 Blocks protein families:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: ALS_HUMAN, P35858
    Similarity: Contains 19 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Function
    for IGFALS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ALS_HUMAN, P35858
    Function: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell
    adhesion

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): IGFALS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFALS
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGFALS
    SwitchGear 3'UTR luciferase reporter plasmid: IGFALS 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFALS (see all 7)
    OriGene shRNA RFP: IGFALS
    OriGene siRNA: IGFALS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFALS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IGFALS

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGFALS (see all 4)
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    GenScript: all cDNA clones in your preferred vector (see all 2): IGFALS (NM_004970)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFALS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFALS 

    Cell Line
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    Search LifeMap BioReagents cell lines for IGFALS

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFALS

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005520insulin-like growth factor binding TAS1379671
    GO:0008022protein C-terminus binding ----


    IGFALS for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Igfalstm1Yrb for IGFALS
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Igfals):
     growth/size  limbs/digits/tail  reproductive system  skeleton 

    IGFALS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IGFALS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    		Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)1.00
    2Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for IGFALS
        Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Metabolism of proteins



    IGFALS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGFALS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/12 Interacting proteins for IGFALS (P358583 ENSP000002155394) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGF1P050193, ENSP000003026654I2D: score=2 STRING: ENSP00000302665
    IGFBP5P245933, ENSP000002338134I2D: score=2 STRING: ENSP00000233813
    IGFBP3P179363, ENSP000003704734I2D: score=2 STRING: ENSP00000370473
    PDCD6O753403I2D: score=4 
    F2ENSP000003085414STRING: ENSP00000308541
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS1384485


    IGFALS for ontologies           About GeneDecksing



    Drugs & Compounds
    for IGFALS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGFALS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGFALS
    1 Novoseek chemical compound relationship for IGFALS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 0 1 15212656 (1)

    Search CenterWatch for drugs/clinical trials and news about IGFALS / ALS 

    Transcripts
    for IGFALS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IGFALS gene (2 alternative transcripts): 
    NM_001146006.1  NM_004970.2  

    Unigene Cluster for IGFALS:

    Insulin-like growth factor binding protein, acid labile subunit
    Hs.839  [show with all ESTs]
    Unigene Representative Sequence: NM_001146006
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215539(uc002cmy.3 uc010uvo.2) ENST00000415638(uc010uvn.2)
    ENST00000568221

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGFALS
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGFALS
    SwitchGear 3'UTR luciferase reporter plasmid: IGFALS 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGFALS (see all 7)
    OriGene shRNA RFP: IGFALS
    OriGene siRNA: IGFALS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGFALS
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGFALS (see all 2)
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    GenScript: all cDNA clones in your preferred vector (see all 2): IGFALS (NM_004970)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFALS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGFALS 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IGFALS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGFALS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGFALS

    Additional cDNA sequence: 

    AK292182.1 AK303146.1 AK313198.1 AK315808.1 BC025681.1 M86826.1 NR_027389.1 

    3 DOTS entries:

    DT.40105965  DT.120716875  DT.120716744 

    3 AceView cDNA sequences:

    M86826 BC025681 NM_004970 

    GeneLoc Exon Structure


    Expression
    for IGFALS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGFALS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCGGCCCCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IGFALS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeVisceral White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See IGFALS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGFALS

    SOURCE GeneReport for Unigene cluster: Hs.839

    UniProtKB/Swiss-Prot: ALS_HUMAN, P35858
    Tissue specificity: Plasma

        SABiosciences Expression via Pathway-Focused PCR Array including IGFALS: 
              Hepatotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFALS

    Orthologs
    for IGFALS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for IGFALS gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IGFALS1 insulin-like growth factor binding protein, acid labile subunit less 67.94(n)
    60.23(a)    		   427649  XM_425222.3  XP_425222.3 
    lizard
    (Anolis carolinensis)    		 Reptilia IGFALS6
    		 --
    		 60(a)
    		 1 ↔ 1
    		 GL343649.1(345319-347055)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-66h3.11 si:ch211-66h3.1 55.85(n)
    52.84(a)    		   570758  XM_003198155.1  XP_003198203.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Toll-73 defense response transmembrane receptor 31(a)
    (best of 10)    		   56F3   --


    ENSEMBL Gene Tree for IGFALS (if available)
    TreeFam Gene Tree for IGFALS (if available) 

    Paralogs
    for IGFALS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGFALS gene
    FLRT12  GP52  CPN22  LRIG32  LRRTM42  CHAD2  FLRT32  LRRC152  
    LRIG22  LRRTM32  CHADL2  LRIG12  LRRTM22  FLRT22  VASN2  LRRTM12  
    1 SIMAP similar gene for IGFALS using alignment to 3 protein entries:     ALS_HUMAN (see all proteins):
    LRIG3

    IGFALS for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IGFALS
    PGOHUM00000237081


    Genomic Variants
    for IGFALS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/226 NCBI SNPs in IGFALS are shown (see all 226)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs574153331,2
    		--1762872(+) AGGGCA/GGTGGC 3 -- ds50010--------
    rs713857171,2
    		C,F--1762893(+) CCAGGC/TGGGGG 3 -- ds50012Minor allele frequency- T:0.50NA 4
    rs725472461,2
    		F--1763013(-) CGGCAG/CAGCAA 3 -- ds50015Minor allele frequency- C:0.01MN 392
    rs340076121,2
    		C,F,--1763191(-) TGAGAG/AACCGT 3 -- ds50015Minor allele frequency- A:0.01NA EU CSAM EA 380
    rs339880591,2
    		C,F,--1763263(-) GGGCTC/TGGCGC 3 -- ds500113Minor allele frequency- T:0.12NA EU CSAM EA MN WA 1142
    rs750715741,2
    		C--1763824(-) GCCCAA/CCAGCC 5 N T mis10--------
    rs351287021,2
    		C--1764125(-) GCCTGG/AGACGC 5 /R /G mis16Minor allele frequency- A:0.00NA EU CSAM EA 4304
    rs355000471,2
    		F--1765308(-) CCCCCC/TGCAGG 4 P syn1 int15Minor allele frequency- T:0.01NA EU CSAM EA 380
    rs734837621,2
    		C,--1765482(+) GCTTCC/ACACCC 3 -- int12Minor allele frequency- A:0.21WA 120
    rs1118442341,2
    		--1765589(+) GTCTCG/AGGCTG 3 -- int12Minor allele frequency- A:0.05CSA WA 120

    HapMap Linkage Disequilibrium report for IGFALS (1840414 - 1844972 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for IGFALS
         5 CNVs: 49667 29999 5329 49668 49666
    Human Gene Mutation Database (HGMD): IGFALS

    Locus Specific Mutation Databases (LSDB): IGFALS

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGFALS
    DNA2.0 Custom Variant and Variant Library Synthesis for IGFALS

    Disorders / Diseases
    for IGFALS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGFALS for disorders           About GeneDecksing

    OMIM gene information: 601489    OMIM disorders: --

    11 diseases for IGFALS:    About MalaCards
    acid-labile subunit    precocious puberty    testicular germ cell tumor    germ cell tumor
    acromegaly    breast cancer    pulmonary disease    prostate cancer
    atherosclerosis    prostatitis    central precocious puberty

    1 Novoseek disease relationship for IGFALS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 0.865 2 17063263 (1)

    Human Genome Epidemiology (HuGE) Navigator: IGFALS (18 documents)

    Export disorders for IGFALS gene to outside databases

    Publications
    for IGFALS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGFALS gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with IGFALS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex. (PubMed id 1379671)1, 2, 3 Leong S.R.... Wood W.I. (1992)
    2. Conservation of a growth hormone-responsive promoter element in the human and mouse acid-labile subunit genes. (PubMed id 10650966)1, 2, 9 Suwanichkul A.... Powell D.R. (2000)
    3. Acid-labile subunit deficiency: phenotypic similariti es and differences between human and mouse. (PubMed id 16114275)1, 3, 9 DomenAc H.M....Boisclair Y.R. (2005)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    6. High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum. (PubMed id 2473065)1, 2 Baxter R.C.... Beniac V.A. (1989)
    7. Primary acid-labile subunit deficiency due to recessive IGFALS mutations results in postnatal growth deficit associated with low circulating insulin growth factor (IGF)-I, IGF binding protein-3 levels, and hyperinsulinemia. (PubMed id 18303074)1, 9 Heath K.E....Campos-Barros A. (2008)
    8. Human acid-labile subunit deficiency: clinical, endoc rine and metabolic consequences. (PubMed id 19729943)1, 9 DomenAc H.M....Rosenfeld R.G. (2009)
    9. Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3. (PubMed id 9446566)1, 9 Firth S.M....Baxter R.C. (1998)
    10. Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins. (PubMed id 19129715)1, 9 Fofanova-Gambetti O.V....Rosenfeld R.G. (2009)

    External Searches for IGFALS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing IGFALS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3483 HGNC: 5468 AceView: IGFALS Ensembl:ENSG00000099769 euGenes: HUgn3483
    ECgene: IGFALS H-InvDB: IGFALS

    Other Databases showing IGFALS gene

    (According to HUGE)
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    Specialized Databases showing IGFALS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGFALS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IGFALS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for IGFALS gene:
    Search GeneIP for patents involving IGFALS

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