IGFALS Gene

Aliases
for IGFALS gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC16M001857 GC16M001780

Summaries
for IGFALS gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for IGFALS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000016.9  NC_018927.2  NT_010393.17  

SwitchGear Promoter luciferase reporter plasmid: IGFALS promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGFALS

IGFALS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001840:  view genomic region     (about GC identifiers)

Proteins
for IGFALS gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for IGFALS: NX_P35858

Explore proteomics data for IGFALS at MOPED

Post-translational modifications: 

IGFALS Human Recombinant Protein Products:

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	antibodies-online peptides for IGFALS

IGFALS Antibody Products:

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IGFALS Assay Products:

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	antibodies-online kits for IGFALS (13 products)

Domains /
Families
for IGFALS gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P35858

Find genes that share domains with IGFALS           About GenesLikeMe

Function
for IGFALS gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Igfals)

genOway: Develop your customized and physiologically relevant rodent model for IGFALS

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		Predesigned siRNA for gene silencing in human, mouse, rat IGFALS

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for IGFALS

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		GenScript: all cDNA clones in your preferred vector (see all 2): IGFALS (NM_004970)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGFALS
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGFALS
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFALS

Localization
for IGFALS gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
nucleus	4
lysosome	1
plasma membrane	1

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Gene Ontology (GO): 5 cellular component terms:    About this table

Pathways & Interactions
for IGFALS gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for IGFALS About     See pathways by source

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	SuperPath	Contained pathways About
1	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Metabolism of proteins 0.30
2	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

1 Reactome Pathway for IGFALS

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for IGFALS gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for IGFALS gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for IGFALS gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IGFALS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCGGCCCCCC

About this image

Adipose (Muscoskeletal System)    fully expand to see all 3 entries
Visceral White Adipocytes Visceral White Adipose
Body Subcutaneous White Adipose
Inner Cell Mass (Early Embryonic Tissues)
Blimp1- mVenus and stella-ECFP genetically modified stem cells

Primer Products:		OriGene qPCR primer pairs and template standards for IGFALS OriGene qSTAR qPCR primer pairs in human, mouse for IGFALS
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		QuantiFast Probe-based Assays in human, mouse, rat IGFALS

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGFALS

Orthologs
for IGFALS gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for IGFALS gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for IGFALS gene

GP5²  CPN2²  LRIG3²  LRRTM4²  CHAD²  LRRC15²  LRIG2²  LRRTM3²  

CHADL²  LRIG1²  LRRTM2²  LRRTM1²  LRG1²  

1 SIMAP similar gene for IGFALS using alignment to 3 protein entries:     ALS_HUMAN (see all proteins):

LRIG3

Find genes that share paralogs with IGFALS           About GenesLikeMe


1 Pseudogenes.org Pseudogene for IGFALS
PGOHUM00000237081

Genomic Variants
for IGFALS gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IGFALS (see all 314)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs574153331,2		--	1774917(+)	AGGGCA/GGTGGC	3	--	ds5001		0	--	--	--	--
rs713857171,2	C,F	--	1774938(+)	CCAGGC/TGGGGG	3	--	ds5001		2		NA	4
rs455865411,2	C,F	--	1774960(-)	CCCGGC/TTTGGC	3	--	ds5001		17		NA EU CSAM EA NS MN	2614
rs129336101,2	C,F,H	--	1775001(+)	CCAGGC/TAACAC	3	--	ds5001		22		NS EA NA EU CSAM MN	2938
rs725472461,2	F	--	1775058(-)	CGGCAG/CAGCAA	3	--	ds5001		5		MN	392
rs1383996341,2		--	1775085(+)	GTGGTA/GCAGTC	3	--	ds5001		0	--	--	--	--
rs1869208481,2		--	1775117(+)	CTCCCA/GGGCTC	3	--	ds5001		0	--	--	--	--
rs1922304921,2		--	1775153(+)	CTAGGA/GCCACA	3	--	ds5001		0	--	--	--	--
rs340076121,2	C,F	--	1775236(-)	TGAGAG/AACCGT	3	--	ds5001		5		NA EU CSAM EA	380
rs339880591,2	C,F	--	1775308(-)	GGGCTC/TGGCGC	3	--	ds5001		13		NA EU CSAM EA MN WA	1142

HapMap Linkage Disequilibrium report for IGFALS (1840414 - 1844972 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for IGFALS (see all 19):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2422427	CNV	Duplication	17116639
nsv904954	CNV	Loss	21882294
dgv2541n71	CNV	Loss	21882294
nsv457336	CNV	Loss	19166990
dgv2540n71	CNV	Loss	21882294
nsv905017	CNV	Loss	21882294
dgv2539n71	CNV	Loss	21882294
nsv905034	CNV	Loss	21882294
nsv518641	CNV	Loss	19592680
dgv2542n71	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): IGFALS
Locus Specific Mutation Databases (LSDB): IGFALS

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing IGFALS

DNA2.0 Custom Variant and Variant Library Synthesis for IGFALS

Disorders / Diseases
for IGFALS gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 disease for IGFALS

1 Novoseek inferred disease relationship for IGFALS gene    About this table

Publications
for IGFALS gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex. (PubMed id 1379671)^{1, 2, 3} Leong S.R.... Wood W.I. (Mol. Endocrinol. 1992)
2. Conservation of a growth hormone-responsive promoter element in the human and mouse acid-labile subunit genes. (PubMed id 10650966)^{1, 2, 9} Suwanichkul A.... Powell D.R. (Endocrinology 2000)
3. Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study. (PubMed id 17063263)^{1, 4, 9} Deming S.L....Zheng W. (Breast Cancer Res. Treat. 2007)
4. Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density. (PubMed id 20302654)^{1, 4, 9} Biong M....Kristensen V.N. (BMC Med Genomics 2010)
5. Risk of testicular germ cell tumors and polymorphisms in the insulin-like growth factor genes. (PubMed id 18349294)^{1, 4, 9} Chia V.M....McGlynn K.A. (amp 2008)
6. Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation. (PubMed id 17546465)^{1, 4, 9} Lettre G....Hirschhorn J.N. (Hum. Genet. 2007)
7. Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study. (PubMed id 16404426)^{1, 4, 9} Canzian F....Kaaks R. (Br. J. Cancer 2006)
8. Acid-labile subunit deficiency: phenotypic similarities and differences between human and mouse. (PubMed id 16114275)^{1, 3, 9} DomenAc H.M....Boisclair Y.R. (J. Endocrinol. Invest. 2005)
9. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)^{1, 4} Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
10. Impact of heterozygosity for acid-labile subunit (IGFALS) gene mutations on stature: results from the international acid-labile subunit consortium. (PubMed id 20591980)^{1, 4} Fofanova-Gambetti O.V....Rosenfeld R.G. (J. Clin. Endocrinol. Metab. 2010)

External Searches for IGFALS gene

Genome Databases showing IGFALS gene

Other Databases showing IGFALS gene

Specialized Databases showing IGFALS gene

Products
for IGFALS gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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