Aliases for IGFALS Gene
Aliases for IGFALS Gene
External Ids for IGFALS Gene
- HGNC: 5468
- Entrez Gene: 3483
- Ensembl: ENSG00000099769
- OMIM: 601489
- UniProtKB: P35858
Previous GeneCards Identifiers for IGFALS Gene
- GC16M001857
- GC16M001780
- GC16M001840
Summaries for IGFALS Gene
-
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for IGFALS Gene
IGFALS (Insulin Like Growth Factor Binding Protein Acid Labile Subunit) is a Protein Coding gene. Diseases associated with IGFALS include Acid-Labile Subunit, Deficiency Of and Short Stature Due To Primary Acid-Labile Subunit Deficiency. Among its related pathways are Transport to the Golgi and subsequent modification and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is LRRTM2.
UniProtKB/Swiss-Prot for IGFALS Gene
-
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFALS Gene
Genomics for IGFALS Gene
Regulatory Elements for IGFALS Gene
Enhancers for IGFALS Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around IGFALS on UCSC Golden Path with GeneCards custom track
Promoters for IGFALS Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around IGFALS on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the IGFALS gene promoter:
Regulatory Element Products
Genomic Location for IGFALS Gene
- Chromosome:
- 16
- Start:
- 1,790,413 bp from pter
- End:
- 1,794,971 bp from pter
- Size:
- 4,559 bases
- Orientation:
- Minus strand
Genomic View for IGFALS Gene
Genes around IGFALS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by Ensembl
- 16p13.3 by Entrez Gene
- 16p13.3 by HGNC
IGFALS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGFALS Gene
Proteins for IGFALS Gene
-
Protein details for IGFALS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35858-ALS_HUMAN
- Recommended name:
- Insulin-like growth factor-binding protein complex acid labile subunit
- Protein Accession:
- P35858
- B4DZY8
- E9PGU3
Protein attributes for IGFALS Gene
- Size:
- 605 amino acids
- Molecular mass:
- 66035 Da
- Quaternary structure:
-
- Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.
Protein Expression for IGFALS Gene
Post-translational modifications for IGFALS Gene
Other Protein References for IGFALS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for IGFALS
- Abcam antibodies for ALS
-
Cloud-Clone Corp. Antibodies for IGFALS
- Invitrogen Antibodies for IGFALS
- antibodies-online Antibodies for IGFALS: See all 47
- GeneTex IGFALS antibody for IGFALS
-
Santa Cruz Biotechnology (SCBT) Antibodies for IGFALS
Protein Products
-
OriGene Purified Proteins for IGFALS
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFALS
- Origene Custom Protein Services for IGFALS
-
Cloud-Clone Corp. Proteins for IGFALS
- antibodies-online Proteins for IGFALS: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for IGFALS
- Abcam proteins for ALS
No data available for DME Specific Peptides for IGFALS Gene
Domains & Families for IGFALS Gene
Protein Domains for IGFALS Gene
Suggested Antigen Peptide Sequences for IGFALS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35858- Domain:
-
- Contains 1 LRRCT domain.
- Contains 1 LRRNT domain.
- Similarity:
-
- Contains 19 LRR (leucine-rich) repeats.
No data available for Gene Families for IGFALS Gene
Function for IGFALS Gene
Molecular function for IGFALS Gene
- UniProtKB/Swiss-Prot Function:
- Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
Phenotypes for IGFALS Gene
- MGI mutant phenotypes for IGFALS:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IGFALS:
Animal Models for IGFALS Gene
- MGI Knock Outs for IGFALS:
-
- Igfals tm1Yrb
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for IGFALS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IGFALS gene
- Search ViGene Biosciences for IGFALS
CRISPR Products
-
OriGene CRISPR knockouts for IGFALS
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFALS
- GenScript: Design CRISPR guide RNA sequences for IGFALS
miRNA Products
- Search ViGene Biosciences for IGFALS
Clone Products
- OriGene clones in human for IGFALS
- OriGene ORF clones in human,mouse,rat for IGFALS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for IGFALS
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for IGFALS gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IGFALS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IGFALS gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for IGFALS Gene
Localization for IGFALS Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGFALS Gene
- Secreted, extracellular space.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| lysosome | 1 |
| plasma membrane | 1 |
| vacuole | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0070062 | extracellular exosome | IDA | 19056867 |
Pathways & Interactions for IGFALS Gene
More details on SuperPathways for IGFALSPathways by source for IGFALS Gene
2 Reactome pathways for IGFALS Gene
Interacting Proteins for IGFALS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0044267 | cellular protein metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for IGFALS Gene
Transcripts for IGFALS Gene
mRNA/cDNA for IGFALS Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IGFALS Gene
- Insulin-like growth factor binding protein, acid labile subunit:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for IGFALS
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFALS
- GenScript: Design CRISPR guide RNA sequences for IGFALS
miRNA Products
- Search ViGene Biosciences for IGFALS
Clone Products
- OriGene clones in human for IGFALS
- OriGene ORF clones in human,mouse,rat for IGFALS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for IGFALS
Flow Cytometry Products
Expression for IGFALS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Visceral White Adipocytes Visceral White Adipose
- Body Subcutaneous White Adipose
- Visceral White Adipose
- Inner Cell Mass (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for IGFALS Gene
This gene is overexpressed in Liver (x38.2).
This gene is overexpressed in Serum (33.9), Plasma (11.2), and Synovial fluid (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGFALS Gene
SOURCE GeneReport for Unigene cluster for IGFALS Gene Hs.839
mRNA Expression by UniProt/SwissProt for IGFALS Gene
P35858-ALS_HUMAN
Tissue specificity:
Plasma.
Primer Products
-
OriGene qPCR primer pairs for IGFALS
-
OriGene qPCR primer pairs and template standards for IGFALS
Orthologs for IGFALS Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | IGFALS 35 |
|
||
| IGFALS 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | IGFALS 35 |
|
||
| IGFALS 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Igfals 35 |
|
||
| Igfals 16 |
|
||||
| Igfals 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | IGFALS 35 |
|
||
| IGFALS 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Igfals 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IGFALS 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IGFALS 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IGFALS 35 |
|
||
| IGFALS 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | IGFALS 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | igfals 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-66h3.1 35 |
|
||
| IGFALS 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | 18w 37 |
|
|
|
| BG:DS03192.2 37 |
|
|
|||
| CG5195 37 |
|
|
|||
| CG6749 37 |
|
|
|||
| CG7896 37 |
|
|
|||
| CG8561 37 |
|
|
|||
| CG9562 37 |
|
|
|||
| Toll-7 37 |
|
|
|||
| Tollo 37 |
|
|
|||
| trn 37 |
|
|
|||
| haf 36 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007059 35 |
|
- Species with no ortholog for IGFALS:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IGFALS Gene
Paralogs for IGFALS Gene
(1) SIMAP similar genes for IGFALS Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for IGFALS Gene
Variants for IGFALS Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs9282730 | - | 1,790,926(-) | CATTG(C/T)CCAAC | nc-transcript-variant, reference, missense | |
| rs9282731 | - | 1,790,776(-) | CGCTG(C/T)GGGAC | nc-transcript-variant, reference, missense | |
| rs35947557 | - | 1,792,129(-) | AGAAC(C/T)TCTCC | nc-transcript-variant, reference, missense | |
| rs34297640 | - | 1,791,498(-) | GCGGC(C/T)CCGCA | nc-transcript-variant, reference, missense | |
| VAR_072475 | Acid-labile subunit deficiency (ACLSD) |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422427 | CNV | Duplication | 17116639 |
| nsv904954 | CNV | Loss | 21882294 |
| nsv905017 | CNV | Loss | 21882294 |
| nsv518641 | CNV | Loss | 19592680 |
| dgv2538n71 | CNV | Loss | 21882294 |
| nsv517196 | CNV | Gain+Loss | 19592680 |
| nsv905023 | CNV | Gain | 21882294 |
| dgv2539n71 | CNV | Loss | 21882294 |
| dgv2540n71 | CNV | Loss | 21882294 |
| nsv457336 | CNV | Loss | 19166990 |
| nsv471069 | CNV | Loss | 18288195 |
| dgv2541n71 | CNV | Loss | 21882294 |
| nsv905031 | CNV | Gain+Loss | 21882294 |
| dgv2542n71 | CNV | Loss | 21882294 |
| nsv905034 | CNV | Loss | 21882294 |
| nsv827500 | CNV | Gain | 20364138 |
| dgv2543n71 | CNV | Loss | 21882294 |
| nsv905042 | CNV | Loss | 21882294 |
| nsv482185 | CNV | Gain | 20164927 |
Residual Variation Intolerance Score:
96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.56;
64.99% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for IGFALS Gene
- Human Gene Mutation Database (HGMD)
- IGFALS
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFALS Gene
Disorders for IGFALS Gene
(5) MalaCards diseases for IGFALS Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, and DISEASES
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acid-labile subunit, deficiency of |
|
|
| short stature due to primary acid-labile subunit deficiency |
|
|
| 3-m syndrome 1 |
|
|
| rubinstein-taybi syndrome |
|
|
| noonan syndrome 1 |
|
|
Search IGFALS in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ALS_HUMAN- Acid-labile subunit deficiency (ACLSD) [MIM:615961]: A disorder characterized by severely reduced serum IGF-I and IGFBP-3 concentrations and mild growth retardation. Pubertal delay in boys and insulin insensitivity are common findings. {ECO:0000269 PubMed:14762184, ECO:0000269 PubMed:16507628, ECO:0000269 PubMed:17726072, ECO:0000269 PubMed:18303074, ECO:0000269 PubMed:19129715, ECO:0000269 PubMed:20389102, ECO:0000269 PubMed:21396577, ECO:0000269 PubMed:23488611}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for IGFALS
No data available for Genatlas for IGFALS Gene
Publications for IGFALS Gene
- Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex. (PMID: 1379671) Leong S.R. … Wood W.I. (Mol. Endocrinol. 1992) 2 3 4 67
- Acid-labile subunit deficiency: phenotypic similarities and differences between human and mouse. (PMID: 16114275) DomenAc H.M. … Boisclair Y.R. (J. Endocrinol. Invest. 2005) 2 3 23
- Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density. (PMID: 20302654) Biong M. … Kristensen V.N. (BMC Med Genomics 2010) 3 23
- Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins. (PMID: 19129715) Fofanova-Gambetti O.V. … Rosenfeld R.G. (Horm. Res. 2009) 3 23
- Human acid-labile subunit deficiency: clinical, endocrine and metabolic consequences. (PMID: 19729943) DomenAc H.M. … Rosenfeld R.G. (Horm. Res. 2009) 3 23
Products for IGFALS Gene
- Browse R&D Systems for Antibodies
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- OriGene Purified Proteins for IGFALS
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFALS
- Origene Custom Protein Services for IGFALS
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for IGFALS
- Browse OriGene Inhibitory RNA Products For IGFALS
- OriGene qPCR primer pairs for IGFALS
- OriGene qPCR primer pairs and template standards for IGFALS
- OriGene CRISPR knockouts for IGFALS
- OriGene clones in human for IGFALS
- OriGene ORF clones in human,mouse,rat for IGFALS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript Custom Purified and Recombinant Proteins Services for IGFALS
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- GenScript: Design CRISPR guide RNA sequences for IGFALS
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Plasmid Preparation
- GenScript Custom Peptide Services for IGFALS
- Novus Biologicals Antibodies for IGFALS
- Novus Biologicals proteins and lysates for IGFALS
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for ALS
- Abcam proteins for ALS
- Search for Assays for IGFALS at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for IGFALS
- Cloud-Clone Corp. Proteins for IGFALS
- Cloud-Clone Corp Assay Kits for IGFALS
- Addgene plasmids for IGFALS
- antibodies-online Antibodies for IGFALS: See all 47
- antibodies-online Kits for IGFALS: See all 11
- antibodies-online Proteins for IGFALS: See all 4
- Search antibodies-online for peptides
- GeneTex IGFALS antibody for IGFALS
- Search GeneTex for Proteins for IGFALS
- ViGene Biosciences adenoviral particle packaged cDNA for IGFALS gene
- ViGene Biosciences lentiviral particle packaged cDNA for IGFALS gene
- ViGene Biosciences lentiviral particle packaged cDNA for IGFALS gene
- ViGene Biosciences ready-to-package AAV shRNAs for IGFALS gene
- ViGene Biosciences ready-to-package AAV shRNAs for IGFALS gene
- ViGene Biosciences ready-to-package AAV shRNAs for IGFALS gene
- Search ViGene Biosciences for IGFALS
- Search ViGene Biosciences for IGFALS
- Santa Cruz Biotechnology (SCBT) Antibodies for IGFALS
- Search Santa Cruz Biotechnology (SCBT) for IGFALS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IGFALS
Sources for IGFALS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon