Aliases for IGFALS Gene
External Ids for IGFALS Gene
Previous GeneCards Identifiers for IGFALS Gene
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for IGFALS Gene
IGFALS (Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit) is a Protein Coding gene. Diseases associated with IGFALS include acid-labile subunit, deficiency of and short stature due to primary acid-labile subunit deficiency. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is LRRTM2.
UniProtKB/Swiss-Prot for IGFALS Gene
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion