Aliases for IGF2BP3 Gene
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
GeneCards Summary for IGF2BP3 Gene
IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3) is a Protein Coding gene. Diseases associated with IGF2BP3 include Pancreatic Cancer and Bile Duct Carcinoma. Among its related pathways are Gene Expression and Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is IGF2BP1.
UniProtKB/Swiss-Prot for IGF2BP3 Gene
RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.