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IGF2BP3 Gene

protein-coding   GIFtS: 56
GCID: GC07M023316

Insulin-Like Growth Factor 2 MRNA Binding Protein 3

  See IGF2BP3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin-Like Growth Factor 2 MRNA Binding Protein 31 2     VICKZ Family Member 32 3
IMP32 3 5     IGF II MRNA Binding Protein 31
KOC12 3 5     CT982
VICKZ32 3 5     KOC2
Cancer/Testis Antigen 981 2     Insulin-Like Growth Factor 2 MRNA-Binding Protein 32
IMP-32 3     KH Domain Containing Protein Overexpressed In Cancer2
IGF-II MRNA-Binding Protein 32 3     hKOC3
IGF2 MRNA-Binding Protein 32 3     KH Domain-Containing Protein Overexpressed In Cancer3

External Ids:    HGNC: 288681   Entrez Gene: 106432   Ensembl: ENSG000001362317   OMIM: 6082595   UniProtKB: O004253   

Export aliases for IGF2BP3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGF2BP3 Gene:
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the
insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during
late development. The encoded protein contains several KH domains, which are important in RNA binding and are
known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative
pseudogenes on other chromosomes. (provided by RefSeq, Jul 2008)

GeneCards Summary for IGF2BP3 Gene:
IGF2BP3 (insulin-like growth factor 2 mRNA binding protein 3) is a protein-coding gene. Diseases associated with IGF2BP3 include pilomyxoid astrocytoma. GO annotations related to this gene include mRNA 3'-UTR binding and RNA binding. An important paralog of this gene is IGF2BP2.

UniProtKB/Swiss-Prot: IF2B3_HUMAN, O00425
Function: RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs).
This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and
location at which target transcripts encounter the translational apparatus and shields them from endonuclease
attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell
adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the
5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs

Gene Wiki entry for IGF2BP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the IGF2BP3 gene promoter:
         AML1a   Lmo2   FOXD3   RORalpha2   Egr-2   S8   HOXA5   MRF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IGF2BP3 promoter sequence
   Search Chromatin IP Primers for IGF2BP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGF2BP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p11   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15.3

IGF2BP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF2BP3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M023316:  view genomic region     (about GC identifiers)

Start:
23,349,828 bp from pter      End:
23,510,086 bp from pter
Size:
160,259 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 23,401,705-23,561,835     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IF2B3_HUMAN, O00425 (See protein sequence)
Recommended Name: Insulin-like growth factor 2 mRNA-binding protein 3  
Size: 579 amino acids; 63705 Da
Subunit: Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts
with IGF2BP1. Interacts with ELAVL1, DHX9 and HNRNPU
Miscellaneous: Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas
1 PDB 3D structure from and Proteopedia for IGF2BP3:
2E44 (3D)    
Secondary accessions: A0A4Z5 Q63HM0 Q6MZZ2 Q86VB1
Alternative splicing: 2 isoforms:  O00425-1   O00425-2   

Explore the universe of human proteins at neXtProt for IGF2BP3: NX_O00425

Explore proteomics data for IGF2BP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys138, Lys213, Lys272, Lys280, Lys440, Lys450, Lys465, Lys508
  • Modification sites at PhosphoSitePlus

  • See IGF2BP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006538.2  
    ENSEMBL proteins: 
     ENSP00000258729   ENSP00000395936  
    Reactome Protein details: O00425

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    Cloud-Clone Corp. Proteins for IGF2BP3

     
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    antibodies-online proteins for IGF2BP3 (3 products) 

     
    antibodies-online peptides for IGF2BP3

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    antibodies-online antibodies for IGF2BP3 (41 products) 

    IGF2BP3 Assay Products:

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    antibodies-online kits for IGF2BP3 (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR004087 KH_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR004088 KH_dom_type_1
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O00425

    ProtoNet protein and cluster: O00425

    3 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB004087 KH domain
    IPB004088 KH


    UniProtKB/Swiss-Prot: IF2B3_HUMAN, O00425
    Domain: All KH domains contribute binding to target mRNA. They are also required for RNA-dependent homo- and
    heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules
    Similarity: Belongs to the RRM IMP/VICKZ family
    Similarity: Contains 4 KH domains
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with IGF2BP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF2B3_HUMAN, O00425
    Function: RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs).
    This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and
    location at which target transcripts encounter the translational apparatus and shields them from endonuclease
    attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell
    adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the
    5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS9891060
    GO:0003730mRNA 3'-UTR binding IDA--
    GO:0005515protein binding IPI17289661
         
    Find genes that share ontologies with IGF2BP3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IGF2BP3

    miRNA
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    miRTarBase miRNAs that target IGF2BP3:
    hsa-let-7b-5p (MIRT032297), hsa-let-7e-5p (MIRT051466), hsa-mir-186-5p (MIRT045123), hsa-mir-34a-5p (MIRT025416), hsa-let-7d-5p (MIRT032130), hsa-mir-320a (MIRT044404), hsa-mir-196a-5p (MIRT026059)

    Block miRNA regulation of human, mouse, rat IGF2BP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGF2BP3 (see all 54):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-100* hsa-miR-640 hsa-miR-607 hsa-miR-3152-3p hsa-let-7d hsa-miR-548k
    SwitchGear 3'UTR luciferase reporter plasmidIGF2BP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IGF2BP3

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    Addgene plasmids for IGF2BP3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IF2B3_HUMAN, O00425: Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear
    region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell
    contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA
    in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with IGF2BP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGF2BP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Gene Expression0.40
    2Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
    Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)


    Find genes that share SuperPaths with IGF2BP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for IGF2BP3
        Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGF2BP3
    Interactions:

        GeneGlobe Interaction Network for IGF2BP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for IGF2BP3 (O004252, 3 ENSP000002587294) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG482, 3, ENSP000003448184MINT-6488791 I2D: score=1 STRING: ENSP00000344818
    PUF60Q9UHX13, ENSP000003220164I2D: score=2 STRING: ENSP00000322016
    KHDRBS2Q5VWX13, ENSP000002811564I2D: score=1 STRING: ENSP00000281156
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS9891060
    GO:0009653anatomical structure morphogenesis TAS9891060
    GO:0010467gene expression TAS--
    GO:0017148negative regulation of translation ISS9891060
    GO:0042035regulation of cytokine biosynthetic process IC9891060

    Find genes that share ontologies with IGF2BP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGF2BP3 (IF2B3)

    1 Novoseek inferred chemical compound relationship for IGF2BP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 1 11782402 (1)



    Find genes that share compounds with IGF2BP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IGF2BP3 gene: 
    NM_006547.2  

    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258729(uc003swf.3 uc003swg.3) ENST00000421467 ENST00000498363
    ENST00000467592 ENST00000497563 ENST00000480547 ENST00000495009 ENST00000468263
    ENST00000492771 ENST00000479504 ENST00000466809 ENST00000491719 ENST00000465058
    ENST00000469723 ENST00000474105 ENST00000476938 ENST00000468005(uc003swh.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IGF2BP3 (see all 54):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-100* hsa-miR-640 hsa-miR-607 hsa-miR-3152-3p hsa-let-7d hsa-miR-548k
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      QuantiFast Probe-based Assays in human, mouse, rat IGF2BP3

    Selected AceView cDNA sequences (see all 173):

    BF438877 BE869656 AA722962 AA252545 BC065269 BQ008452 NM_006547 AA741476 
    AU117427 BM725034 AU142785 AW511295 AA905172 CB148108 AI206172 AA932674 
    BM680244 AW674709 AI743038 AI088047 AA917039 AA261821 AI250857 AW471358 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGF2BP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAATGTGC
    IGF2BP3 Expression
    About this image


    IGF2BP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    IGF2BP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGF2BP3 Protein Expression

    UniProtKB/Swiss-Prot: IF2B3_HUMAN, O00425
    Tissue specificity: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal
    follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level).
    Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level).
    Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis,
    brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF2BP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for IGF2BP3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igf2bp31 , 5 insulin-like growth factor 2 mRNA binding protein 31, 5 91.82(n)1
    96.55(a)1
      6 (23.82 cM)5
    1404881  NM_023670.31  NP_076159.31 
     490852215 
    chicken
    (Gallus gallus)
    Aves IGF2BP31 insulin-like growth factor 2 mRNA binding protein 3 81.87(n)
    86.01(a)
      420617  NM_001006359.1  NP_001006359.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGF2BP36
    insulin-like growth factor 2 mRNA binding protein ...
    84(a)
    1 ↔ 1
    6(30506585-30589177)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684292 KH domain-containing transcription factor B3 80.19(n)    AF064633.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dvr1rbp2 decapentaplegic and Vg-related 1, RNA binding protein 76.01(n)   30967  BC045873.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Imp6
    IGF-II mRNA-binding protein
    31(a)
    1 → many
    X(10681902-10716815)
    worm
    (Caenorhabditis elegans)
    Secernentea zbp-16
    Protein M88.5, isoform c
    15(a)
    1 → many
    III(4553646-4560350) WBGene00010908


    ENSEMBL Gene Tree for IGF2BP3 (if available)
    TreeFam Gene Tree for IGF2BP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGF2BP3 gene
    IGF2BP22  IGF2BP12  
    4 SIMAP similar genes for IGF2BP3 using alignment to 2 protein entries:     IF2B3_HUMAN (see all proteins):
    IGF2BP1    IGF2BP2    PCBP2    SRSF4

    Find genes that share paralogs with IGF2BP3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for IGF2BP3
    PGOHUM00000243455 PGOHUM00000233261


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGF2BP3 (see all 3672)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384383511,2
    C,Funtested123381693(+) ACTGCA/C/GGGTAG 2 P R mis11NA 4486
    rs1828699131,2
    --23349708(+) TCAAGA/GTTCAC 1 -- ds50010--------
    rs1470296901,2
    --23349728(+) CATGGC/GTGGAC 1 -- ds50010--------
    rs1861943271,2
    C--23349759(+) GTAGAA/GTTTGA 1 -- ds50010--------
    rs177967581,2
    C,F,H--23350018(+) TTGCCA/GTACTA 1 -- ut31 ese319Minor allele frequency- G:0.04NA NS EA 1768
    rs1480884551,2
    C--23350087(+) TGTGTA/GTATTT 1 -- ut310--------
    rs1409694151,2
    C--23350181(+) AAAGCC/TAGTCC 1 -- ut310--------
    rs10507151,2
    C--23350214(-) TTTCAT/CACAAT 1 -- ut311Minor allele frequency- C:0.00NA 2
    rs1168913871,2
    C,F--23350226(+) AAAAAT/CCATGA 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1171670141,2
    C,F--23350345(+) TCTAAT/CTGATC 1 -- ut311Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for IGF2BP3 (23349828 - 23510086 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for IGF2BP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663653CNV Deletion23128226
    esv2667690CNV Deletion23128226
    esv26021CNV Loss19812545
    nsv366543CNV Loss16902084
    nsv464408CNV Loss19166990
    nsv887840CNV Loss21882294
    nsv887841CNV Gain21882294
    nsv7393OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IGF2BP3
    DNA2.0 Custom Variant and Variant Library Synthesis for IGF2BP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608259    OMIM disorders: --

    1 disease for IGF2BP3:    
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    pilomyxoid astrocytoma


    Find genes that share disorders with IGF2BP3           About GenesLikeMe

    4 Novoseek inferred disease relationships for IGF2BP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 38.8 67 18547613 (8), 18802962 (5), 17885673 (4), 19449140 (3) (see all 18)
    cancer 32.7 10 18223334 (2), 18802962 (1), 19109797 (1), 19734845 (1) (see all 9)
    carcinoma 32.7 23 17885673 (6), 18223334 (5), 19898970 (4), 19136932 (3) (see all 8)
    metastasis 15.8 8 19672661 (3), 19192721 (2), 19357927 (2), 18260086 (2) (see all 5)

    Genetic Association Database (GAD): IGF2BP3
    Human Genome Epidemiology (HuGE) Navigator: IGF2BP3 (5 documents)

    Export disorders for IGF2BP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGF2BP3 gene, integrated from 10 sources (see all 147):
    (articles sorted by number of sources associating them with IGF2BP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. (PubMed id 9891060)1, 2, 3 Nielsen J.... Nielsen F.C. (Mol. Cell. Biol. 1999)
    2. Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein. (PubMed id 9178771)1, 2, 3 Mueller-Pillasch F.... Gress T.M. (Oncogene 1997)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetes. (PubMed id 20627640)1, 4 Rodriguez S....Day I.N. (amp 2010)
    6. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    7. IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression. (PubMed id 17192788)1, 2 Li C.... Dresser K. (Mod. Pathol. 2007)
    8. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    9. RNA-binding IMPs promote cell adhesion and invadopodia formation. (PubMed id 16541107)1, 2 Vikesaa J.... Nielsen F.C. (EMBO J. 2006)
    10. Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study. (PubMed id 16814207)1, 2 Jiang Z.... Wu C.-L. (Lancet Oncol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10643 HGNC: 28868 AceView: IMP-3 Ensembl:ENSG00000136231 euGenes: HUgn10643
    ECgene: IGF2BP3 H-InvDB: IGF2BP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGF2BP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGF2BP3 gene:
    Search GeneIP for patents involving IGF2BP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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