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Aliases for IGF2BP3 Gene

Aliases for IGF2BP3 Gene

  • Insulin-Like Growth Factor 2 MRNA Binding Protein 3 2 3
  • VICKZ3 3 4 6
  • IMP3 3 4 6
  • KOC1 3 4 6
  • IGF-II MRNA-Binding Protein 3 3 4
  • IGF2 MRNA-Binding Protein 3 3 4
  • Cancer/Testis Antigen 98 2 3
  • VICKZ Family Member 3 3 4
  • IMP-3 3 4
  • KH Domain Containing Protein Overexpressed In Cancer 3
  • KH Domain-Containing Protein Overexpressed In Cancer 4
  • Insulin-Like Growth Factor 2 MRNA-Binding Protein 3 3
  • IGF II MRNA Binding Protein 3 2
  • CT98 3
  • HKOC 4
  • KOC 3

External Ids for IGF2BP3 Gene

Summaries for IGF2BP3 Gene

Entrez Gene Summary for IGF2BP3 Gene

  • The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGF2BP3 Gene

IGF2BP3 (Insulin-Like Growth Factor 2 MRNA Binding Protein 3) is a Protein Coding gene. Diseases associated with IGF2BP3 include pilomyxoid astrocytoma and adenocarcinoma in situ. Among its related pathways are Gene Expression and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include RNA binding and mRNA 3-UTR binding. An important paralog of this gene is IGF2BP1.

UniProtKB/Swiss-Prot for IGF2BP3 Gene

  • RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.

Gene Wiki entry for IGF2BP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF2BP3 Gene

Genomics for IGF2BP3 Gene

Regulatory Elements for IGF2BP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IGF2BP3 Gene

Start:
23,310,209 bp from pter
End:
23,470,491 bp from pter
Size:
160,283 bases
Orientation:
Minus strand

Genomic View for IGF2BP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGF2BP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF2BP3 Gene

Proteins for IGF2BP3 Gene

  • Protein details for IGF2BP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00425-IF2B3_HUMAN
    Recommended name:
    Insulin-like growth factor 2 mRNA-binding protein 3
    Protein Accession:
    O00425
    Secondary Accessions:
    • A0A4Z5
    • Q63HM0
    • Q6MZZ2
    • Q86VB1

    Protein attributes for IGF2BP3 Gene

    Size:
    579 amino acids
    Molecular mass:
    63705 Da
    Quaternary structure:
    • Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts with IGF2BP1. Interacts with ELAVL1, DHX9 and HNRNPU.
    Miscellaneous:
    • Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas

    Three dimensional structures from OCA and Proteopedia for IGF2BP3 Gene

    Alternative splice isoforms for IGF2BP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGF2BP3 Gene

Proteomics data for IGF2BP3 Gene at MOPED

Post-translational modifications for IGF2BP3 Gene

  • Ubiquitination at Lys138, Lys213, Lys272, Lys280, Lys440, Lys450, Lys465, and Lys508
  • Modification sites at PhosphoSitePlus

Other Protein References for IGF2BP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IGF2BP3 Gene

Domains for IGF2BP3 Gene

Gene Families for IGF2BP3 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for IGF2BP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00425

UniProtKB/Swiss-Prot:

IF2B3_HUMAN :
  • O00425
Domain:
  • All KH domains contribute binding to target mRNA. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules.
  • Contains 4 KH domains.
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM IMP/VICKZ family.
genes like me logo Genes that share domains with IGF2BP3: view

Function for IGF2BP3 Gene

Molecular function for IGF2BP3 Gene

UniProtKB/Swiss-Prot Function: RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.

Gene Ontology (GO) - Molecular Function for IGF2BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 9891060
GO:0003730 mRNA 3-UTR binding IDA 20080952
GO:0005515 protein binding IPI 17289661
genes like me logo Genes that share ontologies with IGF2BP3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF2BP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGF2BP3 Gene

Localization for IGF2BP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGF2BP3 Gene

Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGF2BP3 Gene COMPARTMENTS Subcellular localization image for IGF2BP3 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for IGF2BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IGF2BP3: view

Pathways for IGF2BP3 Gene

genes like me logo Genes that share pathways with IGF2BP3: view

Pathways by source for IGF2BP3 Gene

Gene Ontology (GO) - Biological Process for IGF2BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 9891060
GO:0009653 anatomical structure morphogenesis TAS 9891060
GO:0010467 gene expression TAS --
GO:0017148 negative regulation of translation ISS 9891060
GO:0042035 regulation of cytokine biosynthetic process IC 9891060
genes like me logo Genes that share ontologies with IGF2BP3: view

Compounds for IGF2BP3 Gene

(1) Novoseek inferred chemical compound relationships for IGF2BP3 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 1
genes like me logo Genes that share compounds with IGF2BP3: view

Transcripts for IGF2BP3 Gene

Unigene Clusters for IGF2BP3 Gene

Insulin-like growth factor 2 mRNA binding protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF2BP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGF2BP3 Gene

No ASD Table

Relevant External Links for IGF2BP3 Gene

GeneLoc Exon Structure for
IGF2BP3
ECgene alternative splicing isoforms for
IGF2BP3

Expression for IGF2BP3 Gene

mRNA expression in normal human tissues for IGF2BP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGF2BP3 Gene

This gene is overexpressed in Testis (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGF2BP3 Gene

SOURCE GeneReport for Unigene cluster for IGF2BP3 Gene Hs.700696

mRNA Expression by UniProt/SwissProt for IGF2BP3 Gene

O00425-IF2B3_HUMAN
Tissue specificity: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.
genes like me logo Genes that share expressions with IGF2BP3: view

In Situ Assay Products

Orthologs for IGF2BP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGF2BP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGF2BP3 35
  • 99.88 (n)
  • 100 (a)
IGF2BP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGF2BP3 35
  • 91.36 (n)
  • 97.75 (a)
IGF2BP3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGF2BP3 35
  • 94.13 (n)
  • 98.27 (a)
IGF2BP3 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igf2bp3 35
  • 91.82 (n)
  • 96.55 (a)
Igf2bp3 16
Igf2bp3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGF2BP3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGF2BP3 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igf2bp3 35
  • 91.65 (n)
  • 96.89 (a)
chicken
(Gallus gallus)
Aves IGF2BP3 35
  • 81.87 (n)
  • 86.01 (a)
IGF2BP3 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGF2BP3 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68429 35
tropical clawed frog
(Silurana tropicalis)
Amphibia igf2bp3 35
  • 78.7 (n)
  • 84.63 (a)
zebrafish
(Danio rerio)
Actinopterygii dvr1rbp 35
igf2bp3 35
  • 70.31 (n)
  • 77.99 (a)
igf2bp3 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Imp 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zbp-1 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for IGF2BP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IGF2BP3 Gene

ENSEMBL:
Gene Tree for IGF2BP3 (if available)
TreeFam:
Gene Tree for IGF2BP3 (if available)

Paralogs for IGF2BP3 Gene

Paralogs for IGF2BP3 Gene

Selected SIMAP similar genes for IGF2BP3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for IGF2BP3 Gene

genes like me logo Genes that share paralogs with IGF2BP3: view

Variants for IGF2BP3 Gene

Sequence variations from dbSNP and Humsavar for IGF2BP3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs43350 -- 23,406,817(-) actct(A/G)taaaa intron-variant
rs156411 -- 23,320,234(-) AATTT(C/T)TTCAT intron-variant
rs156412 -- 23,319,736(-) TTTCT(C/T)TTAAA intron-variant
rs156413 -- 23,318,018(-) tttct(C/G)cagcc intron-variant
rs156414 -- 23,317,702(-) CCAGC(A/C/G)GAAGC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for IGF2BP3 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887840 CNV Loss 21882294
nsv464408 CNV Loss 19166990
esv2663653 CNV Deletion 23128226
nsv887841 CNV Gain 21882294
nsv366543 CNV Loss 16902084
esv26021 CNV Loss 19812545
esv2667690 CNV Deletion 23128226

Relevant External Links for IGF2BP3 Gene

HapMap Linkage Disequilibrium report
IGF2BP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGF2BP3 Gene

Disorders for IGF2BP3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for IGF2BP3 Gene including...

Search for IGF2BP3 Gene in MalaCards »

(4) Novoseek inferred disease relationships for IGF2BP3 Gene

Disease -log(P) Hits PubMed IDs
tumors 38.8 44
cancer 32.7 10
carcinoma 32.7 25
metastasis 15.8 10

Relevant External Links for IGF2BP3

Genetic Association Database (GAD)
IGF2BP3
Human Genome Epidemiology (HuGE) Navigator
IGF2BP3
genes like me logo Genes that share disorders with IGF2BP3: view

No data available for UniProtKB/Swiss-Prot for IGF2BP3 Gene

Publications for IGF2BP3 Gene

  1. Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein. (PMID: 9178771) Mueller-Pillasch F. … Gress T.M. (Oncogene 1997) 2 3 4
  2. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. (PMID: 9891060) Nielsen J. … Nielsen F.C. (Mol. Cell. Biol. 1999) 2 3 4
  3. Expression of the highly conserved RNA binding protein KOC in embryogenesis. (PMID: 10525192) Mueller-Pillasch F. … Gress T.M. (Mech. Dev. 1999) 3 4
  4. Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies. (PMID: 11465943) Zhang J.-Y. … Tan E.M. (Clin. Immunol. 2001) 3 4
  5. IGF2BP3 (IMP3) expression is a marker of unfavorable prognosis in ovarian carcinoma of clear cell subtype. (PMID: 19136932) KAPbel M. … Gilks C.B. (Mod. Pathol. 2009) 3 23

Products for IGF2BP3 Gene

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