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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGF2BP2 Gene

protein-coding GIFtS: 61
GCID: GC03M185361

insulin-like growth factor 2 mRNA binding protein 2

Explore 18 diseases affiliated with
IGF2BP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Insulin-Like Growth Factor 2 MRNA Binding Protein 2¹ ²		IGF-II MRNA-Binding Protein 2² ³
IMP-2¹ ² ³		IGF2 MRNA-Binding Protein 2² ³
IMP2² ³ ⁵		VICKZ Family Member 2² ³
Hepatocellular Carcinoma Autoantigen P62² ³		Insulin-Like Growth Factor 2 MRNA-Binding Protein 2²
VICKZ2² ³		P62¹

External Ids:	HGNC: 28867¹	Entrez Gene: 10644²	Ensembl: ENSG00000073792⁷	OMIM: 608289⁵	UniProtKB: Q9Y6M1³

Export aliases for IGF2BP2 gene to outside databases

Previous GC identifers: GC03M186845 GC03M182771

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGF2BP2:

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains

several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2

(IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms,

have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IF2B2_HUMAN, Q9Y6M1

Function: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May

regulate translation of target mRNAs

Gene Wiki entry for IGF2BP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGF2BP2 gene promoter:
PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGF2BP2 promoter sequence

Search SABiosciences Chromatin IP Primers for IGF2BP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGF2BP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.2 Ensembl cytogenetic band: 3q27.2 HGNC cytogenetic band: 3q27.2

IGF2BP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF2BP2 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M185361: view genomic region (about GC identifiers)

Start:	185,361,527 bp from pter	End:	185,542,844 bp from pter
Size:	181,318 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IF2B2_HUMAN, Q9Y6M1 (See protein sequence)

Recommended Name: Insulin-like growth factor 2 mRNA-binding protein 2

Size: 599 amino acids; 66121 Da

Subunit: Interacts with HNRPD and IGF2BP1

Subcellular location: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes

at the connecting piece and the tail of the spermatozoa

Miscellaneous: Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma

Sequence caution: Sequence=AAH21290.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for IGF2BP2:

2CQH (3D)

Secondary accessions: A0A4Z0 B3FTN2 B3FTN3 B3FTN4

Alternative splicing, Alternative initiation: 6 isoforms: Q9Y6M1-2 Q9Y6M1-1 Q9Y6M1-3 Q9Y6M1-4 Q9Y6M1-5 Q9Y6M1-6 (Generated by alternative initiation at Met-69)

Explore the universe of human proteins at neXtProt for IGF2BP2: NX_Q9Y6M1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y6M1

IGF2BP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001007226.1 NP_006539.3

ENSEMBL proteins:

ENSP00000371634 ENSP00000410242 ENSP00000320204 ENSP00000413787

Reactome Protein details: Q9Y6M1
Human Recombinant Protein Products:

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	Novus Biologicals IGF2BP2 Proteins Novus Biologicals IGF2BP2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IGF2BP2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	15618018
GO:0005737	cytoplasm	IDA	15618018
GO:0005829	cytosol	TAS	--
GO:0005856	cytoskeleton	IDA	15618018
GO:0044430	cytoskeletal part	--	--

IGF2BP2 for ontologies About GeneDecksing

IGF2BP2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IGF2BP2
	R&D Systems Antibodies for IGF2BP2 (IMP2)
	OriGene Antibodies (see all 12): IGF2BP2 OriGene Custom Antibody Services for IGF2BP2
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	Novus Biologicals IGF2BP2 Antibodies
	Abcam antibodies for IGF2BP2
	Uscn Antibodies for IGF2BP2
	ThermoFisher Antibody for IGF2BP2

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	Uscn ELISAs and CLIAs for IGF2BP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGF2BP2 for domains About GeneDecksing

4 InterPro domains/families:

IPR004087 KH_dom

IPR012677 Nucleotide-bd_a/b_plait

IPR004088 KH_dom_type_1

IPR000504 RRM_dom

Graphical View of Domain Structure for InterPro Entry Q9Y6M1

ProtoNet protein and cluster: Q9Y6M1

2 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB004088 KH

UniProtKB/Swiss-Prot: IF2B2_HUMAN, Q9Y6M1

Domain: The third and fourth KH domains are important for binding to the untranslated region (UTR) of target mRNA

Similarity: Belongs to the RRM IMP/VICKZ family

Similarity: Contains 4 KH domains

Similarity: Contains 2 RRM (RNA recognition motif) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IF2B2_HUMAN, Q9Y6M1

Function: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May

regulate translation of target mRNAs

miRNA Products:		miRTarBase miRNAs that target IGF2BP2: hsa-let-7b (MIRT005241)

		OriGene 3'-UTR Clone (see all 2): IGF2BP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGF2BP2
		8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate IGF2BP2 (see all 74):
		hsa-miR-188-5p hsa-miR-200a hsa-miR-3916 hsa-miR-877* hsa-miR-3622b-3p hsa-miR-3116 hsa-miR-877 hsa-miR-1267

		SwitchGear 3'UTR luciferase reporter plasmid: IGF2BP2 3' UTR sequence

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Gene Editing
Products:

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGF2BP2
		Search LifeMap BioReagents cell lines for IGF2BP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF2BP2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003723	RNA binding	--	--
GO:0003730	mRNA 3'-UTR binding	IDA	--
GO:0005515	protein binding	IPI	12674497
GO:0045182	translation regulator activity	ISS	9891060

IGF2BP2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IGF2BP2:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)

Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)

1.00

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for IGF2BP2

	Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
	Gene Expression

IGF2BP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IGF2BP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/259 Interacting proteins for IGF2BP2 (Q9Y6M1^{1, 2, 3} ENSP00000371634⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 259)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HNRNPD	Q14103-4¹, ENSP00000313199⁴	EBI-1237206,EBI-432545 I2D: score=1 STRING: ENSP00000313199
ICT1	Q14197²^,³, ENSP00000301585⁴	MINT-8079030 I2D: score=1 STRING: ENSP00000301585
MYC	P01106³, ENSP00000367207⁴	I2D: score=4 STRING: ENSP00000367207
PUF60	Q9UHX1³, ENSP00000322016⁴	I2D: score=2 STRING: ENSP00000322016
CDK9	P50750³, ENSP00000362361⁴	I2D: score=1 STRING: ENSP00000362361

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009653	anatomical structure morphogenesis	TAS	9891060
GO:0017148	negative regulation of translation	ISS	9891060
GO:0042035	regulation of cytokine biosynthetic process	IC	9891060

IGF2BP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGF2BP2
Search CenterWatch for drugs/clinical trials and news about IGF2BP2 / IF2B2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IGF2BP2 gene (2 alternative transcripts):

NM_001007225.1 NM_006548.4

Unigene Cluster for IGF2BP2:

Insulin-like growth factor 2 mRNA binding protein 2

Hs.35354 [show with all ESTs]

Unigene Representative Sequence: NM_006548

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000382199(uc010hyj.3 uc010hyk.3 uc010hyl.3 uc003fpo.3 uc003fpp.3 uc003fpq.3)

ENST00000457616 ENST00000346192 ENST00000464166 ENST00000494906 ENST00000496495

ENST00000461957 ENST00000493302 ENST00000466476 ENST00000466214 ENST00000421047(uc010hyi.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): IGF2BP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGF2BP2
		8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate IGF2BP2 (see all 74):
		hsa-miR-188-5p hsa-miR-200a hsa-miR-3916 hsa-miR-877* hsa-miR-3622b-3p hsa-miR-3116 hsa-miR-877 hsa-miR-1267

		SwitchGear 3'UTR luciferase reporter plasmid: IGF2BP2 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGF2BP2

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		GenScript: all cDNA clones in your preferred vector (see all 2): IGF2BP2 (NM_006548)
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Additional cDNA sequence:

AF117107.1 AK290664.1 AK296703.1 AK309611.1 BC021290.2 EU408701.1 EU408702.1 EU408703.1

EU408704.1

12 DOTS entries:

DT.214776 DT.100749533 DT.97787583 DT.102835144 DT.100025556 DT.407946 DT.102835877 DT.120861780

DT.100749528 DT.120861735 DT.120861828 DT.99964011

24/139 AceView cDNA sequences (see all 139):

AA227484 AA173690 AA167255 AI285389 AI928174 BQ212500 BE350202 AA625813

BI858380 AA866025 BQ691878 BM977219 AI803423 AA258565 AA453220 BU741660

AA085622 BX537583 CK429319 AA634300 BX642777 BQ001932 BM561242 BC021290

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IGF2BP2 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	·	11c	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^
SP1:					-						-		-		-						-
SP2:					-						-		-		-						-						-
SP3:																																													-
SP4:											-		-		-						-
SP5:											-		-		-

ExUns:	18a	·	18b	^	19a	·	19b	^	20a	·	20b
SP1:							-
SP2:
SP3:							-
SP4:
SP5:

ECgene alternative splicing isoforms for IGF2BP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGF2BP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTGGTTTA

About this image

IGF2BP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Blood Islands

Primitive Erythrocytes

Blood

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Secondary follicles (Primary Cell)

Ovary, Reproductive System

See IGF2BP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGF2BP2

SOURCE GeneReport for Unigene cluster: Hs.35354

UniProtKB/Swiss-Prot: IF2B2_HUMAN, Q9Y6M1

Tissue specificity: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia

and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta,

skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal

ovary, gonocytes and interstitial cells of the testis

SABiosciences Expression via Pathway-Focused PCR Array including IGF2BP2:

Embryonic Stem Cells in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGF2BP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF2BP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for IGF2BP2 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IGF2BP2¹	insulin-like growth factor 2 mRNA binding protein 2	81.43(n) 87.81(a)		424865 XM_003641746.1 XP_003641794.1
lizard (Anolis carolinensis)	Reptilia	IGF2BP2⁶	--	85(a)	1 ↔ 1	3(34330307-34407658)
zebrafish (Danio rerio)	Actinopterygii	igf2bp2a¹	insulin-like growth factor 2 mRNA binding protein 2a	73.24(n) 78.6(a)		100136839 NM_001114558.2 NP_001108030.2
fruit fly (Drosophila melanogaster)	Insecta	Imp⁶	IGF-II mRNA-binding protein	32(a)	1 → many	X(10681902-10716815)
worm (Caenorhabditis elegans)	Secernentea	M88.5⁶	Protein M88.5, isoform a	18(a)	1 → many	III(4553614-4559894)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G25970⁶ AT4G10070⁶ (see all 3)	KH domain-containing protein (see all 3)	9(a) 7(a) (see all 3)	possible ortholog possible ortholog (see all 3)	2(11071651-11075669) 4(6295608-6299836)
rice (Oryza sativa)	Liliopsida	-- --	KH domain-containing protein, putative, expressed	8(a) 7(a)	possible ortholog possible ortholog	2(6979511-6985051) 8(571856-577417)

ENSEMBL Gene Tree for IGF2BP2 (if available)
TreeFam Gene Tree for IGF2BP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGF2BP2 gene

IGF2BP3² IGF2BP1²

5 SIMAP similar genes for IGF2BP2 using alignment to 3 protein entries: IF2B2_HUMAN (see all proteins):

IGF2BP3 IGF2BP1 NOVA1 PCBP2 PCBP4

IGF2BP2 for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for IGF2BP2
PGOHUM00000239750 PGOHUM00000244961 PGOHUM00000249450 PGOHUM00000263283

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115853324^1,2	C,F,	--	182771086(+)	`CTACAT/CTTCTA`	2	--	ds500¹		1		WA	118
rs6775054^1,2	C,	--	182771087(+)	`tacatT/Gtctaa`	2	--	ds500¹		3		NA WA	6
rs7355809^1,2	C,H	--	182772057(+)	`CGCTAG/AGACAA`	2	--	ut3¹		3		EA NS	298
rs7355810^1,2	C	--	182772107(+)	`GTTGAA/GGCTGG`	2	--	ut3¹ ese³		0	--	--	--	--
rs1063106^1,2	C	--	182772199(-)	`CTCAAT/CCCCGT`	2	--	ut3¹ ese³		2		NA	4
rs1627^1,2	H	--	182772308(+)	`TATGCA/GAAAAA`	2	--	ut3¹ ese³		4		MN EA NS	480
rs55656612^1,2	C	--	182773102(+)	`GGTGCC/TTGTGG`	2	--	ut3¹		0	--	--	--	--
rs78364456^1,2	C,F,	--	182773730(+)	`GGAACA/CGGCTG`	2	--	int¹		1		WA	118
rs9845593^1,2	C,F,H,	--	182773998(+)	`CTGTTT/CGTCTT`	2	--	int¹		3		EA NS	298
rs76936927^1,2		--	182774905(+)	`TGTTGG/ATTGGG`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for IGF2BP2 (185361527 - 185542844 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IGF2BP2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGF2BP2 for disorders           About GeneDecksing

OMIM gene information: 608289
OMIM disorders: 125853
18 diseases for IGF2BP2:    About MalaCards

diabetes mellitus, noninsulin-dependent hepatocellular carcinoma type 2 diabetes mellitus diabetes mellitus

arterial calcification carcinoma gestational diabetes insulin resistance

testicular cancer ovarian cancer gastric cancer pancreatic cancer

prostate cancer pancreatitis atherosclerosis obesity

prostatitis malaria

1 disease from the University of Copenhagen DISEASES database for IGF2BP2:

Diabetes mellitus

2 Novoseek disease relationships for IGF2BP2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	3	15645114 (1), 14767552 (1), 11465943 (1)
cancer	0	2	17426251 (1), 11465943 (1)

Human Genome Epidemiology (HuGE) Navigator: IGF2BP2 (87 documents)

Export disorders for IGF2BP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGF2BP2 gene, integrated from 9 sources (see all 138):
(articles sorted by number of sources associating them with IGF2BP2)

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A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. (PubMed id 9891060)^{1, 2, 3} Nielsen J.... Nielsen F.C. (1999)
A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma. (PubMed id 10190901)^{1, 2, 3} Zhang J.-Y.... Tan E.M. (1999)
Two isoforms of the mRNA binding protein IGF2BP2 are generated by alternative translational initiation. (PubMed id 22427968)^{1, 2} Le H.T.... Siddle K. (2012)
Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)^{1, 2} Joeson L.... Nielsen F.C. (2007)
Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer. (PubMed id 16049158)^{1, 2} Hammer N.A....Nielsen F.C. (2005)
VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins. (PubMed id 15601260)^{1, 2} Yisraeli J.K. (2005)
Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D). (PubMed id 12674497)^{1, 2} Moraes K.C.... Kobarg J. (2003)
HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB. (PubMed id 17426251)^{1, 9} Cleynen I....Petit M.M. (2007)
IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population. (PubMed id 20523342)^{1, 9} Huang Q....Liu Z.Q. (2010)
Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. (PubMed id 17928989)^{1, 9} Horikoshi M....Kadowaki T. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10644	HGNC: 28867	AceView: IMP-2	Ensembl:ENSG00000073792	euGenes: HUgn10644
ECgene: IGF2BP2	H-InvDB: IGF2BP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IGF2BP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IGF2BP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IGF2BP2 gene:
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GeneCards and IP:
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insulin-like growth factor 2 mRNA binding protein 2

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insulin-like growth factor 2 mRNA binding protein 2

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