Aliases for IGF2BP2 Gene
External Ids for IGF2BP2 Gene
Previous GeneCards Identifiers for IGF2BP2 Gene
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014]
GeneCards Summary for IGF2BP2 Gene
IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) is a Protein Coding gene. Diseases associated with IGF2BP2 include Diabetes Mellitus, Noninsulin-Dependent and Hepatocellular Carcinoma. Among its related pathways are Gene Expression and Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is IGF2BP1.
UniProtKB/Swiss-Prot for IGF2BP2 Gene
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.