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Aliases for IGF2BP2 Gene

Aliases for IGF2BP2 Gene

  • Insulin-Like Growth Factor 2 MRNA Binding Protein 2 2 3
  • IMP2 3 4 6
  • IGF-II MRNA-Binding Protein 2 3 4
  • IGF2 MRNA-Binding Protein 2 3 4
  • VICKZ Family Member 2 3 4
  • VICKZ2 3 4
  • IMP-2 3 4
  • Insulin-Like Growth Factor 2 MRNA-Binding Protein 2 3
  • Hepatocellular Carcinoma Autoantigen P62 4
  • IGF II MRNA Binding Protein 2 2

External Ids for IGF2BP2 Gene

Previous GeneCards Identifiers for IGF2BP2 Gene

  • GC03M186845
  • GC03M185361
  • GC03M182771

Summaries for IGF2BP2 Gene

Entrez Gene Summary for IGF2BP2 Gene

  • This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014]

GeneCards Summary for IGF2BP2 Gene

IGF2BP2 (Insulin-Like Growth Factor 2 MRNA Binding Protein 2) is a Protein Coding gene. Diseases associated with IGF2BP2 include diabetes mellitus, noninsulin-dependent and hepatocellular carcinoma. Among its related pathways are Gene Expression and Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs). GO annotations related to this gene include nucleotide binding and translation regulator activity. An important paralog of this gene is IGF2BP1.

UniProtKB/Swiss-Prot for IGF2BP2 Gene

  • RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.

Gene Wiki entry for IGF2BP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF2BP2 Gene

Genomics for IGF2BP2 Gene

Regulatory Elements for IGF2BP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IGF2BP2 Gene

Start:
185,643,739 bp from pter
End:
185,825,056 bp from pter
Size:
181,318 bases
Orientation:
Minus strand

Genomic View for IGF2BP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGF2BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF2BP2 Gene

Proteins for IGF2BP2 Gene

  • Protein details for IGF2BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M1-IF2B2_HUMAN
    Recommended name:
    Insulin-like growth factor 2 mRNA-binding protein 2
    Protein Accession:
    Q9Y6M1
    Secondary Accessions:
    • A0A4Z0
    • B3FTN2
    • B3FTN3
    • B3FTN4

    Protein attributes for IGF2BP2 Gene

    Size:
    599 amino acids
    Molecular mass:
    66121 Da
    Quaternary structure:
    • Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts with HNRPD and IGF2BP1. Interacts with ELAVL1, DHX9 and HNRNPU.
    Miscellaneous:
    • Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma
    SequenceCaution:
    • Sequence=AAH21290.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGF2BP2 Gene

    Alternative splice isoforms for IGF2BP2 Gene

neXtProt entry for IGF2BP2 Gene

Proteomics data for IGF2BP2 Gene at MOPED

Post-translational modifications for IGF2BP2 Gene

  • Ubiquitination at Lys278, Lys419, and Lys444
  • Modification sites at PhosphoSitePlus

Other Protein References for IGF2BP2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IGF2BP2 (IGF2BP2)

No data available for DME Specific Peptides for IGF2BP2 Gene

Domains for IGF2BP2 Gene

Gene Families for IGF2BP2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for IGF2BP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6M1

UniProtKB/Swiss-Prot:

IF2B2_HUMAN :
  • Q9Y6M1
Domain:
  • Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules.
  • Contains 4 KH domains.
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM IMP/VICKZ family.
genes like me logo Genes that share domains with IGF2BP2: view

Function for IGF2BP2 Gene

Molecular function for IGF2BP2 Gene

UniProtKB/Swiss-Prot Function: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript caging into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.

Gene Ontology (GO) - Molecular Function for IGF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0003729 mRNA binding --
GO:0003730 mRNA 3-UTR binding IDA 20080952
genes like me logo Genes that share ontologies with IGF2BP2: view

Phenotypes for IGF2BP2 Gene

GenomeRNAi human phenotypes for IGF2BP2:
genes like me logo Genes that share phenotypes with IGF2BP2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF2BP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGF2BP2 Gene

Localization for IGF2BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGF2BP2 Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGF2BP2 Gene COMPARTMENTS Subcellular localization image for IGF2BP2 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 4
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IGF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15618018
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IDA 15618018
genes like me logo Genes that share ontologies with IGF2BP2: view

Pathways for IGF2BP2 Gene

genes like me logo Genes that share pathways with IGF2BP2: view

Pathways by source for IGF2BP2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IGF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009653 anatomical structure morphogenesis TAS 9891060
GO:0010467 gene expression TAS --
GO:0017148 negative regulation of translation ISS 9891060
GO:0042035 regulation of cytokine biosynthetic process IC 9891060
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with IGF2BP2: view

Transcripts for IGF2BP2 Gene

Unigene Clusters for IGF2BP2 Gene

Insulin-like growth factor 2 mRNA binding protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGF2BP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGF2BP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - - - - - - -
SP8: - - -
SP9:

ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for IGF2BP2 Gene

GeneLoc Exon Structure for
IGF2BP2
ECgene alternative splicing isoforms for
IGF2BP2

Expression for IGF2BP2 Gene

mRNA expression in normal human tissues for IGF2BP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGF2BP2 Gene

SOURCE GeneReport for Unigene cluster for IGF2BP2 Gene Hs.35354

mRNA Expression by UniProt/SwissProt for IGF2BP2 Gene

Q9Y6M1-IF2B2_HUMAN
Tissue specificity: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.
genes like me logo Genes that share expressions with IGF2BP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for IGF2BP2 Gene

Orthologs for IGF2BP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGF2BP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGF2BP2 35
  • 99.89 (n)
  • 100 (a)
IGF2BP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGF2BP2 35
  • 95.05 (n)
  • 98.5 (a)
IGF2BP2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGF2BP2 35
  • 95.04 (n)
  • 98.31 (a)
IGF2BP2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igf2bp2 35
  • 90.99 (n)
  • 95.78 (a)
Igf2bp2 16
Igf2bp2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGF2BP2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGF2BP2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igf2bp2 35
  • 90.48 (n)
  • 96.11 (a)
chicken
(Gallus gallus)
Aves IGF2BP2 35
  • 79.91 (n)
  • 85.71 (a)
IGF2BP2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGF2BP2 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii igf2bp2a 35
  • 72.8 (n)
  • 77.26 (a)
igf2bp2a 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Imp 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zbp-1 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for IGF2BP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IGF2BP2 Gene

ENSEMBL:
Gene Tree for IGF2BP2 (if available)
TreeFam:
Gene Tree for IGF2BP2 (if available)

Paralogs for IGF2BP2 Gene

Paralogs for IGF2BP2 Gene

Selected SIMAP similar genes for IGF2BP2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for IGF2BP2 Gene

genes like me logo Genes that share paralogs with IGF2BP2: view

Variants for IGF2BP2 Gene

Sequence variations from dbSNP and Humsavar for IGF2BP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1627 -- 185,644,726(+) TATGC(A/G)AAAAA utr-variant-3-prime, intron-variant
rs717158 -- 185,771,802(+) TTAGT(C/T)TTGGT intron-variant
rs750753 -- 185,703,859(+) ATATG(A/G)TCTAT intron-variant
rs1047162 -- 185,816,416(+) GTACA(G/T)ATCAC intron-variant
rs1063106 -- 185,644,617(-) CTCAA(C/T)CCCGT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGF2BP2 Gene

Variant ID Type Subtype PubMed ID
esv990977 CNV Deletion 20482838
esv2726326 CNV Deletion 23290073
esv2726327 CNV Deletion 23290073
esv2670919 CNV Deletion 23128226

Relevant External Links for IGF2BP2 Gene

HapMap Linkage Disequilibrium report
IGF2BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGF2BP2 Gene

Disorders for IGF2BP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for IGF2BP2 Gene including...

Search for IGF2BP2 Gene in MalaCards »

(1) OMIM Diseases for IGF2BP2 Gene (608289)

(1) University of Copenhagen DISEASES for IGF2BP2 Gene

(2) Novoseek inferred disease relationships for IGF2BP2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3
cancer 0 2

Relevant External Links for IGF2BP2

Genetic Association Database (GAD)
IGF2BP2
Human Genome Epidemiology (HuGE) Navigator
IGF2BP2
genes like me logo Genes that share disorders with IGF2BP2: view

No data available for UniProtKB/Swiss-Prot for IGF2BP2 Gene

Publications for IGF2BP2 Gene

  1. IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population. (PMID: 20523342) Huang Q. … Liu Z.Q. (Acta Pharmacol. Sin. 2010) 3 23 48
  2. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. (PMID: 9891060) Nielsen J. … Nielsen F.C. (Mol. Cell. Biol. 1999) 2 3 4
  3. A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma. (PMID: 10190901) Zhang J.-Y. … Tan E.M. (J. Exp. Med. 1999) 2 3 4
  4. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. (PMID: 17928989) Horikoshi M. … Kadowaki T. (Diabetologia 2007) 3 23 48
  5. VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins. (PMID: 15601260) Yisraeli J.K. (Biol. Cell 2005) 3 4

Products for IGF2BP2 Gene

Sources for IGF2BP2 Gene

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