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IGF2BP2 Gene

protein-coding   GIFtS: 63
GCID: GC03M185361

Insulin-Like Growth Factor 2 MRNA Binding Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin-Like Growth Factor 2 MRNA Binding Protein 21 2     IGF2 MRNA-Binding Protein 22 3
IMP22 3 5     VICKZ Family Member 22 3
Hepatocellular Carcinoma Autoantigen P622 3     IGF II MRNA Binding Protein 21
IMP-22 3     Insulin-Like Growth Factor 2 MRNA-Binding Protein 22
VICKZ22 3     p622
IGF-II MRNA-Binding Protein 22 3     

External Ids:    HGNC: 288671   Entrez Gene: 106442   Ensembl: ENSG000000737927   OMIM: 6082895   UniProtKB: Q9Y6M13   

Export aliases for IGF2BP2 gene to outside databases

Previous GC identifers: GC03M186845 GC03M182771


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGF2BP2 Gene:
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene
contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like
growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding
different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for IGF2BP2 Gene:
IGF2BP2 (insulin-like growth factor 2 mRNA binding protein 2) is a protein-coding gene. Diseases associated with IGF2BP2 include diabetes mellitus, noninsulin-dependent, and hepatocellular carcinoma. GO annotations related to this gene include translation regulator activity and nucleotide binding. An important paralog of this gene is IGF2BP3.

UniProtKB/Swiss-Prot: IF2B2_HUMAN, Q9Y6M1
Function: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This
transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and
location at which target transcripts encounter the translational apparatus and shields them from endonuclease
attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2
(IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts

Gene Wiki entry for IGF2BP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGF2BP2 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGF2BP2 promoter sequence
   Search Chromatin IP Primers for IGF2BP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGF2BP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.2   Ensembl cytogenetic band:  3q27.2   HGNC cytogenetic band: 3q27.2

IGF2BP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGF2BP2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M185361:  view genomic region     (about GC identifiers)

Start:
185,361,527 bp from pter      End:
185,542,844 bp from pter
Size:
181,318 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IF2B2_HUMAN, Q9Y6M1 (See protein sequence)
Recommended Name: Insulin-like growth factor 2 mRNA-binding protein 2  
Size: 599 amino acids; 66121 Da
Subunit: Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts
with HNRPD and IGF2BP1. Interacts with ELAVL1, DHX9 and HNRNPU
Miscellaneous: Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular
carcinoma
Sequence caution: Sequence=AAH21290.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for IGF2BP2:
2CQH (3D)    
Secondary accessions: A0A4Z0 B3FTN2 B3FTN3 B3FTN4
Alternative splicing, Alternative initiation: 6 isoforms:  Q9Y6M1-2   Q9Y6M1-1   Q9Y6M1-3   Q9Y6M1-4   Q9Y6M1-5   Q9Y6M1-6   (Generated by alternative initiation at Met-69)

Explore the universe of human proteins at neXtProt for IGF2BP2: NX_Q9Y6M1

Explore proteomics data for IGF2BP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys278, Lys419, Lys444
  • Modification sites at PhosphoSitePlus

  • See IGF2BP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001007226.1  NP_006539.3  

    ENSEMBL proteins: 
     ENSP00000371634   ENSP00000410242   ENSP00000320204   ENSP00000413787  
    Reactome Protein details: Q9Y6M1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    5 InterPro protein domains:
     IPR004087 KH_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR028743 IGF2BP2
     IPR004088 KH_dom_type_1
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6M1

    ProtoNet protein and cluster: Q9Y6M1

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB004088 KH


    UniProtKB/Swiss-Prot: IF2B2_HUMAN, Q9Y6M1
    Domain: Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The
    contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and
    KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1
    cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for
    localization to stress granules
    Similarity: Belongs to the RRM IMP/VICKZ family
    Similarity: Contains 4 KH domains
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    IGF2BP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF2B2_HUMAN, Q9Y6M1
    Function: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This
    transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and
    location at which target transcripts encounter the translational apparatus and shields them from endonuclease
    attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2
    (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003730mRNA 3'-UTR binding IDA--
    GO:0005515protein binding IPI12674497
         
    IGF2BP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IGF2BP2:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target IGF2BP2:
    hsa-mir-877-5p (MIRT037361), hsa-mir-331-3p (MIRT043535), hsa-mir-125a-3p (MIRT038642), hsa-mir-98-5p (MIRT027853), hsa-let-7b-5p (MIRT005241), hsa-mir-18a-5p (MIRT000792), hsa-mir-335-5p (MIRT018969)

    Block miRNA regulation of human, mouse, rat IGF2BP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGF2BP2 (see all 74):
    hsa-miR-188-5p hsa-miR-200a hsa-miR-3916 hsa-miR-877* hsa-miR-3622b-3p hsa-miR-3116 hsa-miR-877 hsa-miR-1267
    SwitchGear 3'UTR luciferase reporter plasmidIGF2BP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IGF2BP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IF2B2_HUMAN, Q9Y6M1: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated
    mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as
    oxidative stress, recruited to stress granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    nucleus4
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15618018
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IDA15618018

    IGF2BP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGF2BP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Gene Expression0.40
    2Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
    Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for IGF2BP2
        Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA



    IGF2BP2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including IGF2BP2: 
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IGF2BP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for IGF2BP2 (Q9Y6M11, 2, 3 ENSP000003716344) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPDQ14103-41, ENSP000003131994EBI-1024419,EBI-432545 I2D: score=1 STRING: ENSP00000313199
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    MYCP011063, ENSP000003672074I2D: score=4 STRING: ENSP00000367207
    PUF60Q9UHX13, ENSP000003220164I2D: score=2 STRING: ENSP00000322016
    CDK9P507503, ENSP000003623614I2D: score=1 STRING: ENSP00000362361
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009653anatomical structure morphogenesis TAS9891060
    GO:0010467gene expression TAS--
    GO:0017148negative regulation of translation ISS9891060
    GO:0042035regulation of cytokine biosynthetic process IC9891060
    GO:0051028mRNA transport IEA--

    IGF2BP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGF2BP2 (IF2B2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IGF2BP2 gene (2 alternative transcripts): 
    NM_001007225.1  NM_006548.4  

    Unigene Cluster for IGF2BP2:

    Insulin-like growth factor 2 mRNA binding protein 2
    Hs.35354  [show with all ESTs]
    Unigene Representative Sequence: NM_006548
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382199(uc010hyj.3 uc010hyk.3 uc010hyl.3 uc003fpo.3 uc003fpp.3 uc003fpq.3)
    ENST00000457616 ENST00000346192 ENST00000464166 ENST00000494906 ENST00000496495
    ENST00000461957 ENST00000493302 ENST00000466476 ENST00000466214 ENST00000421047(uc010hyi.3)

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    hsa-miR-188-5p hsa-miR-200a hsa-miR-3916 hsa-miR-877* hsa-miR-3622b-3p hsa-miR-3116 hsa-miR-877 hsa-miR-1267
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    Additional mRNA sequence: 

    AF117107.1 AK290664.1 AK296703.1 AK309611.1 BC021290.2 EU408701.1 EU408702.1 EU408703.1 
    EU408704.1 

    11 DOTS entries:

    DT.214776  DT.100749533  DT.97787583  DT.102835144  DT.407946  DT.100025556  DT.102835877  DT.120861780 
    DT.120861735  DT.120861828  DT.99964011 

    Selected AceView cDNA sequences (see all 139):

    BX282561 BM977219 BI962503 BM806132 CF593505 AI803423 CK429319 AA031861 
    AA085622 AI538388 CK819327 BM453327 AI285389 BU741660 BU674692 BM843467 
    BQ001932 BM128614 AA258565 AA625813 BX537583 NM_006548 BQ212500 BM561242 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IGF2BP2 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:              -                 -     -     -                 -                                                                                             
    SP2:              -                 -     -     -                 -                 -                                                                           
    SP3:                                                                                                                                      -                     
    SP4:                                -     -     -                 -                                                                                             
    SP5:                                -     -     -                                                                                                               

    ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b
    SP1:                    -               
    SP2:                                    
    SP3:                    -               
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for IGF2BP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGF2BP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTGGTTTA
    IGF2BP2 Expression
    About this image


    IGF2BP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primary Follicle
             Secondary follicles
     
     Gonad
             Primary Oocyte Primary Follicle
    IGF2BP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGF2BP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.35354

    UniProtKB/Swiss-Prot: IF2B2_HUMAN, Q9Y6M1
    Tissue specificity: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells,
    spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly
    in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected
    in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis

        Pathway & Disease-focused RT2 Profiler PCR Array including IGF2BP2: 
              Embryonic Stem Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGF2BP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IGF2BP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igf2bp21 , 5 insulin-like growth factor 2 mRNA binding protein 21, 5 90.99(n)1
    95.78(a)1
      16 (13.02 cM)5
    3197651  NM_183029.21  NP_898850.21 
     220590095 
    chicken
    (Gallus gallus)
    Aves IGF2BP21 insulin-like growth factor 2 mRNA binding protein 2 79.91(n)
    85.71(a)
      424865  XM_003641746.2  XP_003641794.2 
    lizard
    (Anolis carolinensis)
    Reptilia IGF2BP26
    insulin-like growth factor 2 mRNA binding protein ...
    66(a)
    1 ↔ 1
    3(34329656-34407658)
    zebrafish
    (Danio rerio)
    Actinopterygii igf2bp2a1 insulin-like growth factor 2 mRNA binding protein 2a 72.8(n)
    77.26(a)
      100136839  NM_001114558.2  NP_001108030.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Imp6
    IGF-II mRNA-binding protein
    31(a)
    1 → many
    X(10681902-10716815)
    worm
    (Caenorhabditis elegans)
    Secernentea zbp-16
    Protein M88.5, isoform c
    17(a)
    1 → many
    III(4553646-4560350) WBGene00010908


    ENSEMBL Gene Tree for IGF2BP2 (if available)
    TreeFam Gene Tree for IGF2BP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGF2BP2 gene
    IGF2BP32  IGF2BP12  
    6 SIMAP similar genes for IGF2BP2 using alignment to 3 protein entries:     IF2B2_HUMAN (see all proteins):
    IGF2BP3    IGF2BP1    NOVA1    PCBP2    PCBP4    KHSRP

    IGF2BP2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for IGF2BP2
    PGOHUM00000239750 PGOHUM00000244961 PGOHUM00000249450 PGOHUM00000263283


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGF2BP2 (see all 3210)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3756246141,2
    C--182803017(+) CTTTT-/CTTTTT 2 -- int10--------
    rs2007236151,2
    C--182808846(+) AAGAAA/GGGGGG 2 -- int10--------
    rs1921974021,2
    C--182833733(+) ACAGGA/GAAAAA 2 -- int10--------
    rs114015451,2
    C--182835366(+) AGCCTG/-GGCAA 2 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs634357611,2
    C--182840897(+) AAAAAA/-CAATA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1500618671,2
    C--182892380(+) AGTAA-/ATAAAAA 2 -- int10--------
    rs1876127811,2
    C--182892381(+) GTAAAA/TAAAAA 2 -- int10--------
    rs1130488021,2
    C--182902785(+) GTCTCAA/-AAAAA 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs76286571,2
    C,F--182914270(+) taaacT/Attttt 2 -- int1 trp32Minor allele frequency- A:0.50NA CSA 4
    rs1161149481,2
    C,F--182922607(+) TCCTCG/ACATTA 2 -- int11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for IGF2BP2 (185361527 - 185542844 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IGF2BP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726326CNV Deletion23290073
    esv2726327CNV Deletion23290073
    esv2670919CNV Deletion23128226
    esv990977CNV Deletion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IGF2BP2
    DNA2.0 Custom Variant and Variant Library Synthesis for IGF2BP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608289   
    OMIM disorders: 125853  
    18 diseases for IGF2BP2:    
    About MalaCards
    diabetes mellitus, noninsulin-dependent    hepatocellular carcinoma    gestational diabetes    embryonal rhabdomyosarcoma
    testicular cancer    diabetes mellitus    diabetic nephropathy    rhabdomyosarcoma
    insulin resistance    type 1 diabetes    obesity    atherosclerosis
    pancreatic cancer    ovarian cancer    pancreatitis    schizophrenia
    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for IGF2BP2:
    Diabetes mellitus

    IGF2BP2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for IGF2BP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 15645114 (1), 14767552 (1), 11465943 (1)
    cancer 0 2 17426251 (1), 11465943 (1)

    Genetic Association Database (GAD): IGF2BP2
    Human Genome Epidemiology (HuGE) Navigator: IGF2BP2 (87 documents)

    Export disorders for IGF2BP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGF2BP2 gene, integrated from 10 sources (see all 162):
    (articles sorted by number of sources associating them with IGF2BP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. (PubMed id 9891060)1, 2, 3 Nielsen J.... Nielsen F.C. (Mol. Cell. Biol. 1999)
    2. A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma. (PubMed id 10190901)1, 2, 3 Zhang J.-Y.... Tan E.M. (J. Exp. Med. 1999)
    3. IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population. (PubMed id 20523342)1, 4, 9 Huang Q....Liu Z.Q. (Acta Pharmacol. Sin. 2010)
    4. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. (PubMed id 17928989)1, 4, 9 Horikoshi M....Kadowaki T. (Diabetologia 2007)
    5. A genome-wide association study of gestational diabetes mellitus in Korean women. (PubMed id 22233651)1, 4 Kwak S.H....Park K.S. (Diabetes 2012)
    6. Two isoforms of the mRNA binding protein IGF2BP2 are generated by alternative translational initiation. (PubMed id 22427968)1, 2 Le H.T.... Siddle K. (PLoS ONE 2012)
    7. Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas. (PubMed id 21573907)1, 4 Parra E.J....Cruz M. (Diabetologia 2011)
    8. Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. (PubMed id 20550665)1, 4 Lin Y....Yang Z. (BMC Med. Genet. 2010)
    9. Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. (PubMed id 20802253)1, 4 Heni M....HAoring H.U. (Diabetes 2010)
    10. Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps. (PubMed id 19808892)1, 4 't Hart L.M....Fritsche A. (Diabetes 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10644 HGNC: 28867 AceView: IMP-2 Ensembl:ENSG00000073792 euGenes: HUgn10644
    ECgene: IGF2BP2 H-InvDB: IGF2BP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGF2BP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGF2BP2 gene:
    Search GeneIP for patents involving IGF2BP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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